NEDACHI TAKU 根建拓

… Alternative Names

NEDACHI Taku 根建拓

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Researcher Number	50375200
Other IDs
Affiliation (Current)	2025: 東洋大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 東洋大学, 生命科学部, 教授 2011 – 2021: 東洋大学, 生命科学部, 教授 2010 – 2011: 東洋大学, 生命科学部, 准教授 2008 – 2009: The University of Tokyo, 大学院・農学生命科学研究科, 特任研究員 2007: Tohoku University, 先進医工学研究機構, 助教 2005 – 2006: 東北大学, 先進医工学研究機構, 助手
Review Section/Research Field	Principal Investigator Applied biochemistry / Basic Section 59040:Nutrition science and health science-related / Basic Section 42030:Animal life science-related / Integrative animal science / Science and Engineering Except Principal Investigator Metabolomics / Biological Sciences / Basic Section 08030:Family and consumer sciences, and culture and living-related / Nanobioscience / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator 骨格筋 / 運動 / シグナル伝達 / 伸展 / 免疫 / 分泌タンパク質 / ストレス / 収縮 / バイオマーカー / アクアポリン … More / 暑熱馴化 / miRNA / エクソソーム / 免疫制御 / 運動因子 / マイオカイン / Sirtuin / 細胞工学 / 収縮パターン / 代謝 / 成長因子 / 神経幹細胞 / 分化 / 物理的ストレス / 神経前駆細胞 / 増殖因子 / ストレス応答 / 神経幹/前駆細胞 / 分泌因子 / 動物細胞 / バイオ操作 / 培養細胞 / ストレッチ / 電気パルス / 生物材料 / 細胞内シグナル / 筋細胞 / マイクロアレイ / プロテオーム / 糖尿病 / 細胞・組織 / 応用動物 … More Except Principal Investigator GLUT4 / インスリン / 小胞輸送 / 筋細胞 / 糖尿病 / 糖代謝 / 顕微鏡 / 脂肪細胞 / 単一分子観察 / ナノ蛍光粒子 / 骨格筋 / 乳酸菌 / サルコペニア / ポストバイオティクス / Galectin 3 / AGEs / 固定化技術 / 生活習慣 / リガンド / バイオセンサ / ガレクチン / 相互作用 / 神経新生 / 神経変性 / 成長因子 / 脳・神経 / 筋収縮 / ナノ材料 / シグナル伝達 / イメージング / 細胞内小胞輸送 / 骨格筋細胞 / 電気パルス / サルコメア構造 / 運動効果 / 培養 / 培養装置 / 細胞内カルシウム / 運動 / 培養細胞 / 筋肉 / FRET / 1分子イメージング / ナノ技術 / 糖輸送 / 視覚化技術 Less

暑熱馴化による骨格筋アクアポリンの制御とその生理的意義Principal Investigator
- Principal Investigator
  
  根建拓
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Toyo University
ポストバイオティクスに立脚したサルコペニア予防食品素材の開発
- Principal Investigator
  
  石田達也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Toyo University
Exercise-dependent regulation of skeletal muscle-derived exosomesPrincipal Investigator
- Principal Investigator
  
  Nedachi Taku
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Toyo University
Elucidation of motor dysfunction based on galectin network and lifestyle risk diagnosis
- Principal Investigator
  
  Miyanishi Nobumitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nanobioscience
- Research Institution
  Toyo University
Role of contraction-dependent myokines on the immune systemPrincipal Investigator
- Principal Investigator
  
  Nedachi Taku
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Toyo University
Application of in vitro C2C12 contractile model that mimics different types of exercisePrincipal Investigator
- Principal Investigator
  
  NEDACHI Taku
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyo University
Physiological actions and pathological relevance of growth factors in the brain
- Principal Investigator
  
  NISHIHARA Masugi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Effects of mechanical stresses on neural stem/progenitor cellsPrincipal Investigator
- Principal Investigator
  
  NEDACHI Taku
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyo University
生体材料・医用材料として有用な培養細胞由来骨格筋モデルの創製Principal Investigator
- Principal Investigator
  
  根建拓
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Characterization of novel exercise factors in skeletal musclePrincipal Investigator
- Principal Investigator
  
  NEDACHI Taku
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  The University of Tokyo
収縮筋細胞における糖輸送担体GLUT4の分子挙動解析
- Principal Investigator
  
  神崎展
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Analysis of proteins regulating GLUT4 translocation
- Principal Investigator
  
  KANZAKI Makoto
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
高度発達型筋細胞系を用いた運動刺激依存的なGLUT4膜移行制御機構の解明Principal Investigator
- Principal Investigator
  
  根建拓
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Tohoku University
ナノテクノロジーを駆使したインスリン依存性糖輸送システムの統合的解析
- Principal Investigator
  
  KANZAKI Makoto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
糖代謝能研究に適した高度分化型培養筋管細胞系の確立
- Principal Investigator
  
  神崎展
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University

[Book] 骨格筋研究を核とした筋スマート社会2019
- Author(s)
  根建　拓、石内友里
- Total Pages
  362
- Publisher
  シーエムシー・リサーチ
- Data Source
  KAKENHI-PROJECT-19K06442
[Book] 骨格筋研究を核とした筋スマート社会2019
- Author(s)
  根建　拓、石内友里
- Publisher
  シーエムシー・リサーチ
- Data Source
  KAKENHI-PROJECT-16K08077
[Book] Progranulin and Central Nervous System Disorders2019
- Author(s)
  Nedachi T
- Total Pages
  183
- Publisher
  Springer Nature Singapore Pte Ltd.
- Data Source
  KAKENHI-PROJECT-19K06442
[Book] GLUT4小胞輸送とインスリン抵抗性新時代の糖尿病学12008
- Author(s)
  有賀美也子・根建拓・神崎展
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-18390266
[Book] 生体の代謝環境を改善するResveratrol2007
- Author(s)
  根建拓
- Total Pages
  2
- Publisher
  実験医学 25(3) : 381-382
- Data Source
  KAKENHI-PROJECT-18780068
[Book] セラミド合成とインスリン抵抗性2007
- Author(s)
  根建拓
- Total Pages
  2
- Publisher
  実験医学 25(9):1331-1332
- Data Source
  KAKENHI-PROJECT-18780068
[Book] 寿命決定会議の新たなメンバー2006
- Author(s)
  根建拓
- Total Pages
  2
- Publisher
  実験医学 24(9) : 1306-1307
- Data Source
  KAKENHI-PROJECT-18780068
[Book] 創傷治癒における内在性電場の役割2006
- Author(s)
  根建拓
- Total Pages
  1
- Publisher
  実験医学 24(16) : 2498
- Data Source
  KAKENHI-PROJECT-18780068
[Journal Article] Possible involvement of CXC motif chemokine ligand 10 in exercise-induced collagen production of mouse dermal fibroblasts2021
- Author(s)
  Ishiuchi-Sato Yuri、Nedachi Taku
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 11 Pages: 1359-1365
- DOI
  10.1507/endocrj.EJ21-0275
- NAID
  130008121526
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06442
[Journal Article] Hydrogen peroxide induces progranulin expression to control neurite outgrowth in HT22 cells2021
- Author(s)
  Shimoda Ayumu、Tanabe Takemi、Sato Tsubasa、Nedachi Taku
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 10 Pages: 2103-2112
- DOI
  10.1093/bbb/zbab134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06442
[Journal Article] The effects of glucose and fatty acids on CXCL10 expression in skeletal muscle cells2020
- Author(s)
  Ishiuchi-Sato Yuri、Hiraiwa Erika、Shinozaki Ayaka、Nedachi Taku
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84 Issue: 12 Pages: 2448-2457
- DOI
  10.1080/09168451.2020.1814127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06442, KAKENHI-PROJECT-19J10894
[Journal Article] Skeletal muscle cell contraction reduces a novel myokine, chemokine (C-X-C motif) ligand 10 (CXCL10): potential roles in exercise-regulated angiogenesis.2018
- Author(s)
  Ishiuchi Y, Sato H, Tsujimura K, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 82 Issue: 1 Pages: 97-105
- DOI
  10.1080/09168451.2017.1411778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-17H03930
[Journal Article] Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle.2018
- Author(s)
  Ishiuchi Y, Sato H, Komatsu N, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T.
- Journal Title
  
  Cytokine.
  
  Volume: 108 Pages: 17-23
- DOI
  10.1016/j.cyto.2018.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-17H03930
[Journal Article] Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells2017
- Author(s)
  Ken-ichi Kawashima, Yuri Ishiuchi, Miki Konnai, Saori Komatsu, Hitoshi Sato, Hideo Kawaguchi, Nobumitsu Miyanishi, Jerome Lamartine, Masugi Nishihara, Taku Nedachi
- Journal Title
  
  FEBS open bio
  
  Volume: 7 Issue: 2 Pages: 149-159
- DOI
  10.1002/2211-5463.12164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K04910, KAKENHI-PROJECT-16K08077
[Journal Article] Glucose deprivation attenuates sortilin levels in skeletal muscle cells2017
- Author(s)
  Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi S
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: 3 Pages: 255-268
- DOI
  10.1507/endocrj.EJ16-0319
- NAID
  130005529466
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] Glutamate levels control HT22 murine hippocampal cell death by regulating biphasic patterns of Erk1/2 activation: role of metabolic glutamate receptor 52016
- Author(s)
  Sato K, Yamanaka Y, Asakura Y, Nedachi T
- Journal Title
  
  Biosci Biotech Biochem
  
  Volume: 80 Issue: 4 Pages: 712-718
- DOI
  10.1080/09168451.2015.1107466
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23228004
[Journal Article] Subtoxic levels of hydrogen peroxide induce brain-derived neurotrophic factor expression to protect PC12 cells2014
- Author(s)
  Ogura Y, Sato K, Kawashima KI, Kobayashi N, Imura S, Fujino K, Kawaguchi H, Nedachi T
- Journal Title
  
  BMC Research Notes
  
  Volume: 7 Issue: 1 Pages: 840-840
- DOI
  10.1186/1756-0500-7-840
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24580147
[Journal Article] Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells2014
- Author(s)
  Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T
- Journal Title
  
  Biosci Biotech Biochem
  
  Volume: 78 Issue: 9 Pages: 1495-1503
- DOI
  10.1080/09168451.2014.936343
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-24580147, KAKENHI-PROJECT-25430042
[Journal Article] Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells2014
- Author(s)
  Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23228004
[Journal Article] Lysine suppresses protein degradation through autophagic-lysosomal system in C2C12 myotubes2014
- Author(s)
  Sato T, Ito Y, Nedachi T, Nagasawa T
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 391 Issue: 1-2 Pages: 37-46
- DOI
  10.1007/s11010-014-1984-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580147, KAKENHI-PROJECT-24614002
[Journal Article] Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells2013
- Author(s)
  Fujino K, Ogura Y, Sato K, Nedachi T
- Journal Title
  
  Neurosci Lett
  
  Volume: 557 (B) Pages: 148-153
- DOI
  10.1016/j.neulet.2013.10.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580147
[Journal Article] Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3βphosphorylation2011
- Author(s)
  Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M
- Journal Title
  
  Neuroscience
  
  Volume: 185 Pages: 106-115
- DOI
  10.1016/j.neuroscience.2011.04.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20248030, KAKENHI-PROJECT-22658090, KAKENHI-PROJECT-23228004
[Journal Article] Involvement of progranulin in modulating behavior and neurodegeneration2011
- Author(s)
  Nedachi T, Matsuwaki T, Nishihara M
- Journal Title
  
  Cognition and Dementia
  
  Volume: 10(2) Pages: 44-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article] Progranulin enhances neural progenitor cell proliferation tnrougn glycogen synthase kinase 3beta phosphorylation2011
- Author(s)
  Nedachi T
- Journal Title
  
  Neuroscience
  
  Volume: 185 Pages: 106-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article] Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation2011
- Author(s)
  Nedachi T
- Journal Title
  
  Neuroscience
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article] プログラニュリンと行動・神経変性2011
- Author(s)
  根建拓、松脇貴志、西原真杉
- Journal Title
  
  Cognition and Dementia
  
  Volume: 10 Pages: 140-146
- Data Source
  KAKENHI-PROJECT-23228004
[Journal Article] 特集:認知症の発症にかかわる遺伝子プログラニュリン2010
- Author(s)
  根建拓
- Journal Title
  
  老年医学雑誌
  
  Volume: 21(5) Pages: 555-560
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article] Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation2010
- Author(s)
  Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M
- Journal Title
  
  Neuroscience
  
  Volume: 185 Pages: 106-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article] 特集:認知症の発症にかかわる遺伝子プログラニュリン2010
- Author(s)
  根建拓、松脇貴志、朝倉麗、西原真杉
- Journal Title
  
  老年医学雑誌
  
  Volume: 21(5) Pages: 555-560
- Data Source
  KAKENHI-PROJECT-22780085
[Journal Article]2009
- Author(s)
  Suzuki M, Lee HC, Kayasuga Y, Chiba S, Nedachi T, Matsuwaki T, Yamanouchi K, Nishihara M
- Journal Title
  
  J Reprod Dev 55(4)
  
  Pages: 351-355
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article] Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes2009
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab 297(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20034006
[Journal Article] 成長因子プログラニュリンの機能と神経変性2009
- Author(s)
  根建拓
- Journal Title
  
  実験医学 27(9)
  
  Pages: 1345-1349
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article]2009
- Author(s)
  根建拓、河合隆徳、西原真杉
- Journal Title
  
  実験医学 27(9)
  
  Pages: 1345-1349
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article]2009
- Author(s)
  Nedachi T, Hatakeyama H, Kono T, Sato M, Kanzaki M
- Journal Title
  
  Am J Physiol Endocrinol Metab 297(4)
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article] Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes2009
- Author(s)
  根建拓
- Journal Title
  
  Am J Physiol Endocrinol Metab 297(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article] Contractile C2C12 myotube model for studying exercise-inducible respo nses in skeletal muscle2008
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab 295(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20034006
[Journal Article]2008
- Author(s)
  Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S
- Journal Title
  
  Endocrinology 149(7)
  
  Pages: 3729-42
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article] Contractile C2C12 myotube model for studying contraction-inducible responses of skeletal muscle (2008)2008
- Author(s)
  Nedachi T, Fujita H, Kanzaki M
- Journal Title
  
  Am J Physiol Endocrinol Metab 295 295(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Identification of contraction-inducible myokines and their impact on insulin responsive GLUT4 translocation in C2C12 myotubes2008
- Author(s)
  Nedachi T
- Journal Title
  
  Diabetes 57 suppl
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and Fox03a in C2C12 myocytes2008
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab 294(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20034006
[Journal Article] Ambient Glucose Levels Qualify the Potency of Insulin Myogenic Actions by Regulating SIRT1 and FoxO3a in C2C12 myocytes.2008
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18780068
[Journal Article] Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle2008
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab 295(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article]2008
- Author(s)
  Nedachi T, Fujita H, Kanzaki M
- Journal Title
  
  Am J Physiol Endocrinol Metab 295(5)
- Data Source
  KAKENHI-PROJECT-20780071
[Journal Article] Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle2008
- Author(s)
  Nedachi T
- Journal Title
  
  American Journal of Physiology Endocrinology & Metabolism 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Functional role of sortilin in myogenesis and insulin-responsive glucose transport system in C2C12 myocytes2008
- Author(s)
  Ariga M, Nedachi T, Katagiri H, Kanzaki M
- Journal Title
  
  J Biol. Chem. 283(15)
  
  Pages: 10208-10220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes2008
- Author(s)
  Nedachi T, Kadotani A, Ariga M., Katagiri H, Kanzaki M
- Journal Title
  
  Am. J. Physiol Endocrinol Metab 294(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes2008
- Author(s)
  Nedachi, T., et. al.
- Journal Title
  
  American Journal of Physiology Endocrinology & metabolism 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19037003
[Journal Article] Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes2007
- Author(s)
  Fujita H, Nedachi T, Kanzaki M
- Journal Title
  
  Exp Cell Res 313(9)
  
  Pages: 1853-1865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes2006
- Author(s)
  Nedachi, T et al.
- Journal Title
  
  American J. Physiol. Endocrinol ＆ Metabolism 291
- Data Source
  KAKENHI-PROJECT-17659270
[Journal Article] Development of insulin-responsive GLUT4 trafficking machinery by forced Ca2+ transients in C2C12 myotubes2006
- Author(s)
  Nedachi, T et al.
- Journal Title
  
  Diabetes 55,suppl
- Data Source
  KAKENHI-PROJECT-17659270
[Journal Article] Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes2006
- Author(s)
  Nedachi T, Kanzaki M.
- Journal Title
  
  Am. J. Physiol. Endocrinol & Metab 291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390266
[Journal Article] Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes.2006
- Author(s)
  Nedachi T
- Journal Title
  
  Am J Physiol Endocrinol Metab 291(4)
- Data Source
  KAKENHI-PROJECT-18780068
[Journal Article] Cytoplasmic sequestration of Sir2 that depends upon metabolic states is directly engaged in the differentiation of C2C12 myoblasts2005
- Author(s)
  Nedachi Taku et al.
- Journal Title
  
  Cell Structure and Function 30.suppl.
  
  Pages: 85-85
- Data Source
  KAKENHI-PROJECT-17659270
[Patent] 熱中症マーカー及びその利用2019
- Inventor(s)
  根建　拓
- Industrial Property Rights Holder
  根建　拓
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K06442
[Patent] 運動に応答して筋肉細胞において発現変動するタンパク質及びそれらの受容体、それらをコードする遺伝子、並びにそれらを用いたスクリーニング方法2007
- Inventor(s)
  神崎展、根建拓
- Industrial Property Rights Holder
  東北大学
- Industrial Property Number
  2007-283929
- Filing Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-18780068
[Patent] フィーダー細胞を利用した高度発達型培養筋細胞の作製とその薬効評価システムへの利用2006
- Inventor(s)
  神崎展, 根建拓
- Industrial Property Rights Holder
  東北大学
- Industrial Property Number
  2006-285617
- Filing Date
  2006-10-20
- Data Source
  KAKENHI-PROJECT-18780068
[Patent] 高度発達型培養筋細胞の作製装置とその応用2006
- Inventor(s)
  神崎展, 根建拓, 藤田英明
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2006-09-21
- Data Source
  KAKENHI-PROJECT-18780068
[Presentation] 短期温熱処理による骨格筋マイオカインの動態変化2021
- Author(s)
  村田圭吾、大川俊也、渡邉拓実、佐藤 (石内) 友里、根建拓
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] マウス真皮線維芽細胞における温熱依存的なコラーゲン産生調節2021
- Author(s)
  中島翼空、森彩乃、吉川綾乃、佐藤（石内）友里、根建拓
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] 収縮する骨格筋細胞を駆使することで明らかとなった新規運動効果2020
- Author(s)
  根建　拓
- Organizer
  生物工学会Webシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] 運動制御性マイオカインを介した皮膚機能制御の解明2020
- Author(s)
  佐藤（石内）友里、根建　拓
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] マウスHT22細胞における酸化ストレス依存的な糖鎖修飾の解明2020
- Author(s)
  佐藤飛翔、下田歩夢、宮西伸光、根建　拓
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] 運動依存的なマイオカイン発現変化による皮膚機能制御の解明2019
- Author(s)
  佐藤（石内）友里、根建拓
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] 骨格筋における暑熱依存的なエクソソーム放出の生理的意義2019
- Author(s)
  宮下千穂、郡司美里、石内友里、根建拓
- Organizer
  42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06442
[Presentation] 運動依存的な新規マイオカインの分泌変化及び発現制御メカニズム2018
- Author(s)
  石内友里、根建　拓
- Organizer
  日本筋学会第４回学術集会
- Data Source
  KAKENHI-PROJECT-16K08077
[Presentation] Temperature-dependent secretome profiling in C2C12 myotubes: potential roles of CXCL10 reduction by heat-dependent stress2018
- Author(s)
  Yuri Ishiuchi, Kei Sato, Natsuki Fujinuma, Marie Miegebielle, Taku Nedachi
- Organizer
  2018 ASCB | EMBO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08077
[Presentation] 運動によって制御される骨格筋分泌因子群～マイオカインと細胞外小胞～2018
- Author(s)
  根建　拓
- Organizer
  第1回筋スマート社会コンソーシアム
- Invited
- Data Source
  KAKENHI-PROJECT-16K08077
[Presentation] Gene expression analysis of glycosyltransferases of skeletal muscle cells and its exercised condition in hyperglycemic condition2018
- Author(s)
  Yoshitaka Akutsu, Takumi Wakisaka, Risa Horiuchi, Taku Nedachi, Nobumitsu Miyanishi
- Organizer
  29th International Carbohydrate Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K04910
[Presentation] Structure Analysis of N-glycan containing sialic acid of skeletal muscle cells in hyperglycemic condition2017
- Author(s)
  Y. Akutsu, T. Wakisaka, R. Horiuchi, T. Ishii, T. Nedachi, N. Miyanishi.
- Organizer
  19th European Carbohydrate Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K04910
[Presentation] Mechanism of contraction-dependent CCL5 reduction in C2C12 myotubes2016
- Author(s)
  Sato H, Ishiuchi Y, Kawaguchi H, Nedachi T.
- Organizer
  the EMBO meeting
- Place of Presentation
  Mannheim, Germany
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08077
[Presentation] Comparative analysis of N-glycans in skeketal muscle cells and its exercise condition2016
- Author(s)
  Takumi Wakisaka, Hitoshi Sato, Takayuki Ishii, Risa Horiuchi, Taku Nedachi, Nobumitsu Miyanishi
- Organizer
  Society for Glycobiology Annual Meeting
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K04910
[Presentation] Identification of CXCL10 as contraction-reduced myokine in mouse skeletal muscle2016
- Author(s)
  shiuchi Y, Sato H, Matsuwaki K, Yamanouchi K, Kawaguchi H, Nishihara M, Nedachi T.
- Organizer
  the EMBO meeting
- Place of Presentation
  Mannheim, Germany
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08077
[Presentation] SIRT1 induction by glucose deprivation is mediated by AMP kinase pathway in PC12 cells2013
- Author(s)
  Fujino K, Ogura Y, Sato K, Nedachi T
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートピアアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24580147
[Presentation] Neuroprotective effect of oxidative preconditioning is partially mediated by BDNF signaling in PC12 cells2013
- Author(s)
  Ogura Y, Fujino K, Nedachi T
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートピアアイランド（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24580147
[Presentation] Nutrient availability defines the expression and localization of SIRT1 in PC12 cells2012
- Author(s)
  Fujino K, Hashimoto Y, Nedachi T
- Organizer
  Neuroscience2012
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-24580147
[Presentation] Roles of Progranulin in Differentiated and Undifferentiated Neural Cells2011
- Author(s)
  Nedachi T, Kawai T, Kojima H, Matsuwaki T, Yamanouchi K, Nishihara M
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22780085
[Presentation] Roles of Progranulin in Differentiated and Undifferentiated Neural Cells2011
- Author(s)
  Nedachi T
- Organizer
  Society for Neurosciecne 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22780085
[Presentation] 培養細胞由来運動骨格筋モデルを用いた新規運動因子の同定とその機能解析2009
- Author(s)
  根建拓
- Organizer
  第7回特定領域研究公開シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-20034006
[Presentation]2008
- Author(s)
  Nedachi T, et. al.
- Organizer
  68th American Diabetes Association Scientific Sessions
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-20780071
[Presentation] Identification of contraction-inducible myokines and their impact on insulin responsive GLUT4 translocation in C2C12 myotubes2008
- Author(s)
  Nedachi T
- Organizer
  68^<th> American Diabetes Association Scientific Sessions
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-20780071
[Presentation] 高度発達型培養筋細胞の開発と応用2008
- Author(s)
  根建拓
- Organizer
  第6回特定領域研究公開シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-20034006
[Presentation] 新規培養細胞由来運動骨格筋モデルの創製とその応用2008
- Author(s)
  根建拓
- Organizer
  特定領域若手研究者第3回ワークショップ
- Place of Presentation
  沖縄
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20034006
[Presentation] Identification of contraction-inducible myokines and their impact on insulin responsive GLUT4 translocation in C2C12 myotubes2008
- Author(s)
  Nedachi T
- Organizer
  第68回アメリカ糖尿病学会
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Qdotを用いたGLUT4分子挙動解析-TIRF顕微鏡による膜融合過程の観察-2007
- Author(s)
  藤田英明・渡邊朋信・根建拓・樋口秀男・神崎展
- Organizer
  第47回生体医工学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] 展筋のインスリン反応性に対する運動効果の解析-収縮能を有する高度発達型培養筋細胞系の構築-2007
- Author(s)
  根建拓・藤田英明・神崎展
- Organizer
  第50回日本糖尿病学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] 筋のインスリン反応性に対する運動効果の解析-収縮能を有する高度発達型培養筋細胞系の構築-2007
- Author(s)
  根建拓, ら
- Organizer
  第50回日本糖尿病学会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19037003
[Presentation] 高度発達型培養筋細胞の作製技術とその糖尿病研究への利用2007
- Author(s)
  根建拓, ら
- Organizer
  第47回日本生体医工学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19037003
[Presentation] 高度発達型培養筋細胞の作製技術とその糖尿病研究への利用2007
- Author(s)
  根建拓・藤田英明・神崎展
- Organizer
  第47回生体医工学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] 収縮筋細胞内におけるGLUT4分子の挙動解析2007
- Author(s)
  藤田英明・渡邊朋信・根建拓・樋口秀男・神崎展
- Organizer
  第45回生物物理学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] 新規高度発達型培養筋細胞系におけるGLUT4膜移行を指標とした疑似運動刺激効果の検討2006
- Author(s)
  根建拓・藤田英明・神崎展
- Organizer
  第49回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Development of insulin-responsive GLUT4 trafficking machinery by forced Ca2+ transients in C2C12 myotubes2006
- Author(s)
  Nedachi T, Fujita, H, Kanzaki, M
- Organizer
  66^<th> American Diabetes Association Scientific Sessions第66回アメリカ糖尿病学会
- Place of Presentation
  Washington DC(Diabetes55 : (suppl1) : A242 (1022-P))
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Degradation of Sir2 by ubiquitin-proteasome pathway that depends upon metabolic states controls C2C12 cell differentiation2006
- Author(s)
  Nedachi,T, Kanzaki, M
- Organizer
  20^<th> International Congress of Biochemistry and Molecular Biology(第20回国際生化学・分子生物学会)
- Place of Presentation
  Kyoto539(4P-A-028)
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Sortilin regulates myogenesis and insulin-induced GLUT4 translocation in C2C12 myocytes2006
- Author(s)
  Ariga, M, Nedachi, T, Katagiri, H. Kanzaki,M
- Organizer
  20^<th> International Congress of Biochemistry and Molecular Biology(第20回国際生化学・分子生物学会)
- Place of Presentation
  Kyoto366(2P-C-145)
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Live cell tracking of GLUT4 molecule in 3T3L1 adipocyte using Qdot nano-crystals2006
- Author(s)
  Fujita H, Watanabe T, Nedachi, T, Higuchi,H, Kanzaki,M
- Organizer
  46^<th> The American Society for Cell Biology Annual Meeting(アメリカ細胞生物学会)
- Place of Presentation
  San Diago
- Data Source
  KAKENHI-PROJECT-18390266
[Presentation] Density-dependent dual effects of oxidative stress in HT22 murine hippocampal cells
- Author(s)
  Miura K, Ishii M, Ishibashi K, Ogura Y, Nishihara M, Nedachi T
- Organizer
  Society for Neuroscience, 43rd Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] Potential role of progranulin in neural progenitor cells
- Author(s)
  Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M
- Organizer
  41st Annual Meeting, Society for Neuroscience
- Place of Presentation
  Washington DC (U.S.A.)
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] C2C12筋管細胞における収縮依存的なRANTESの分泌制御
- Author(s)
  佐藤整、柴垣拓也、佐藤和典、根建拓
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学（岡山市）
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24580147
[Presentation] 培養神経細胞を用いたプログラニュリンの神経保護作用の解析
- Author(s)
  小嶋春佳、根建拓、山内啓太郎、西原真杉
- Organizer
  第153回　日本獣医学会
- Place of Presentation
  大宮ソニックシティ（埼玉県）
- Data Source
  KAKENHI-PROJECT-23228004
[Presentation] PGRN-dependent regulation of SIRT1 in neural progenitor cells
- Author(s)
  Sato S, Miura K, Tsutiya A, Tanaka Y, Ohtani-Kaneko R, Nishihara M, Nedachi T
- Organizer
  Society for Neuroscience, 43rd Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23228004

1. KANZAKI Makoto (10272262)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. 藤田英明 (50318804)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. KAWAGUCHI Hideo (50416921)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. Miyanishi Nobumitsu (80372720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. NISHIHARA Masugi (90145673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. HASEGAWA Masato (10251232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMANOUCHI Keitaro (70272440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. NAKAYAMA Hiroyuki (40155891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUWAKI Takashi (20447361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 加藤和則 (60233780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石田達也 (90356262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 矢野友啓 (50239828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NEDACHI TAKU 根建 拓

NEDACHI Taku 根建 拓

Research Projects

Research Products

Co-Researchers

暑熱馴化による骨格筋アクアポリンの制御とその生理的意義Principal Investigator

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ポストバイオティクスに立脚したサルコペニア予防食品素材の開発

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Exercise-dependent regulation of skeletal muscle-derived exosomesPrincipal Investigator

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Elucidation of motor dysfunction based on galectin network and lifestyle risk diagnosis

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Role of contraction-dependent myokines on the immune systemPrincipal Investigator

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Application of in vitro C2C12 contractile model that mimics different types of exercisePrincipal Investigator

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Physiological actions and pathological relevance of growth factors in the brain

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Effects of mechanical stresses on neural stem/progenitor cellsPrincipal Investigator

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生体材料・医用材料として有用な培養細胞由来骨格筋モデルの創製Principal Investigator

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Characterization of novel exercise factors in skeletal musclePrincipal Investigator

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収縮筋細胞における糖輸送担体GLUT4の分子挙動解析

Principal Investigator

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Analysis of proteins regulating GLUT4 translocation

Principal Investigator

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高度発達型筋細胞系を用いた運動刺激依存的なGLUT4膜移行制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

NEDACHI TAKU 根建拓

NEDACHI Taku 根建拓