TOH RYUJI 杜隆嗣

… Alternative Names

TOH Ryuji 杜隆嗣

杜隆嗣トウリュウジ

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Researcher Number	50379418
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 医学研究員
Affiliation (based on the past Project Information) *help	2014 – 2024: 神戸大学, 医学研究科, 特命准教授 2017: 神戸大学, 大学院医学研究科内科系講座立証検査医学分野, 特命准教授 2015: 神戸大学, 医学(系)研究科(研究院), 特命准教授 2015: 神戸大学, 大学院医学研究科, 特命准教授 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 准教授 … More 2012: 神戸大学, 医学研究科, 准教授 2012: 神戸大学, 大学院・医学研究科, 院医学研究科 2011: 神戸大学, 医学(系)研究科(研究院), 研究員 2011: 神戸大学, 医学研究科, 医学研究員 2010: 神戸大学, 医学部附属病院, 助教 2007: Kobe University, 医学部・附属病院, 助教 2006: 神戸大学, 医学系研究科, 医学研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Circulatory organs internal medicine / Cardiovascular medicine Except Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Laboratory medicine / Metabolomics / Circulatory organs internal medicine
Keywords	Principal Investigator 心血管病 / コレステロール取り込み能 / 動脈硬化 / 高比重リポ蛋白 / 心不全 / コレステリルエステル転送蛋白 / 高HDLコレステロール血症 / 高比重リポ蛋白（HDL） / コレステロール逆転送 / 高比重リポ蛋白（HDL) … More / 高比重リポ蛋白(HDL) / グルタチオン / 2-アミノ酪酸 / ケトン体 / βヒドロキシ酪酸 / メタボローム解析 / 脂肪酸解析 / HDL / 再狭窄 / 炎症 / ミエロペルオキシダーゼ / パラオキソナーゼ / 冠動脈疾患 / HDL機能不全 / serum response factor(SRF) / ヒストン修飾 / Na^+-Ca2+ exchanger(NCX) / serum response factor (SRF) / エピジェネティクス / 心肥大 … More Except Principal Investigator 心不全 / 高比重リポ蛋白 / メタボローム解析 / 動脈硬化 / 循環器 / 心筋代謝 / グルタミン / 血栓 / トランス脂肪酸 / 高比重リポタンパク質 / グルタチオン / 2-アミノ酪酸 / コレステロール / 心肥大 / HDL / 脂肪酸 / 脂質代謝 / 脂質代謝物 / 認知症 / フレイル / 心臓リモデリング / グルタミン代謝 / 心筋代謝リモデリング / 心臓線維化 / グルタミン分解 / グルタミナーゼ1 / グルタミノリシス / スペックルトラッキング心エコー図法 / 悪性リンパ腫 / がん治療関連心機能障害 / フィブロネクチン / 低比重リポ蛋白（HDL） / ドキソルビシン / 乳がん / がん治療関連心機能障害（CTRCD） / 高密度リポタンパク質 / メタボローム / 石灰化病変 / 画像診断 / 大動脈石灰化病変 / 催不整脈作用 / 脂肪酸プロファイル / 心房細動 / 血栓症 / 脂質代謝異常 / コレステロール引き抜き / リポタンパク質 / オメガ3系多価不飽和脂肪酸 / 逆転送 / エイコサペンタエン酸 / 脂質異常症 / 冠動脈疾患 / コレステロール逆転送 / 抗がん剤 / 心エコー図 / 左室拡張能 / 肥満 / 糖尿病 / βヒドロキシ酪酸 / 脂肪酸代謝 / エネルギー代謝 / 酸化ストレス / VE-カドヘリン / 接着分子 / 血管新生 / 血管内皮細胞 / angiogenesis / JCAD / コレステロール取り込み能 / パラオキソナーゼ１ / ミエロペルオキシダーゼ / リポ蛋白 / 心筋 / エネルギー / リパーゼ / 血管内皮 / 炎症 Less

超高齢社会における健康寿命延伸に寄与する脂質代謝物の探索的研究
- Principal Investigator
  
  石田達郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
新たなHDL機能指標による高HDLコレステロール血症におけるリスク評価法の構築Principal Investigator
- Principal Investigator
  
  杜隆嗣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Elucidation of regulatory mechanisms of glutamine metabolism in heart failure and development of novel therapeutic strategies
- Principal Investigator
  
  Satomi-Kobayashi Seimi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Elucidation of the interaction between cells and HDL with multifaceted actions
- Principal Investigator
  
  Irino Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Early detection and prevention of cancer therapeutics-related cardiac dysfunction
- Principal Investigator
  
  Tanaka Hidekazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Clinical utility of cholesterol uptake capacity, a novel indicator for HDL functionalityPrincipal Investigator
- Principal Investigator
  
  Toh Ryuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kobe University
Role of Fatty acids in the pathogenesis of arrhythmia and thrombosis
- Principal Investigator
  
  Fukuzawa Koji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
Establishment of a novel therapeutic strategy for heart failure based on an understanding of metabolic regulation
- Principal Investigator
  
  Tanaka Hidekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
Clinical significance of cholesterol uptake capacity, a novel assay of high-density lipoprotein function, in coronary artery disease
- Principal Investigator
  
  Tatsuro Ishida
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
The role of Trans-fatty acids in deep venous thrombosis
- Principal Investigator
  
  Hideto Nakajima
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Discovery of novel treatment strategy for aortic calcification through CT imaging and metabolome analysis
- Principal Investigator
  
  Takaya Tomofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kobe University
Metabolomic Identification of Novel Regulators of Cardiac Oxidative Stress in Heart FailurePrincipal Investigator
- Principal Investigator
  
  TOH RYUJI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
A comprehensive analysis of high density lipoprotein function
- Principal Investigator
  
  HIRATA KEN-ICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
The role of JCAD, an adhesion molecule of endothelial cell, in regulating cardiovascular disease
- Principal Investigator
  
  kawai hiroya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
Metabolomics in heart failure
- Principal Investigator
  
  TANAKA Hidekazu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kobe University
Effects of dysfunctional HDL on coronary artery diseasePrincipal Investigator
- Principal Investigator
  
  TOH Ryuji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
Effect of high-density lipoprotein on cardiac function
- Principal Investigator
  
  KAWAI Hiroya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University
心肥大から心不全への移行におけるエピジェネティックなクロマチン修飾の関与についてPrincipal Investigator
- Principal Investigator
  
  杜隆嗣
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kobe University

[Book] 2-アミノ酪酸による体内酸化防止機能　～新たなグルタチオン代謝制御機構の発見～2017
- Author(s)
  杜　隆嗣、入野　康宏
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-26461070
[Book] HDLコレステロール2014
- Author(s)
  杜　隆嗣、平田　健一
- Total Pages
  9
- Publisher
  血管医学
- Data Source
  KAKENHI-PROJECT-25461085
[Journal Article] Impaired Cholesterol Uptake Capacity in Patients with Hypertriglyceridemia and Diabetes Mellitus2024
- Author(s)
  Seto Yutaro、Nagao Manabu、Iino Takuya、Harada Amane、Murakami Katsuhiro、Miwa Keiko、Shinohara Masakazu、Nishimori Makoto、Yoshikawa Sachiko、Asakura Junko、Fujioka Tomoo、Ishida Tatsuro、Hirata Ken-ichi、Toh Ryuji
- Journal Title
  
  The Journal of Applied Laboratory Medicine
  
  Volume: - Issue: 4 Pages: 728-740
- DOI
  10.1093/jalm/jfae024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07506
[Journal Article] Plasma cystine/methionine ratio is associated with left ventricular diastolic function in patients with heart disease2023
- Author(s)
  Asakura Junko、Nagao Manabu、Shinohara Masakazu、Nishimori Makoto、Yoshikawa Sachiko、Iino Takuya、Seto Yutaro、Tanaka Hidekazu、Satomi-Kobayashi Seimi、Ishida Tatsuro、Hirata Ken-ichi、Toh Ryuji
- Journal Title
  
  Heart and Vessels
  
  Volume: 38 Issue: 12 Pages: 1422-1430
- DOI
  10.1007/s00380-023-02302-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08205, KAKENHI-PROJECT-21K08105
[Journal Article] Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling2022
- Author(s)
  Yoshikawa Sachiko、Nagao Manabu、Toh Ryuji、Shinohara Masakazu、Iino Takuya、Irino Yasuhiro、Nishimori Makoto、Tanaka Hidekazu、Satomi-Kobayashi Seimi、Ishida Tatsuro、Hirata Ken-Ichi
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 322 Issue: 5 Pages: H749-H761
- DOI
  10.1152/ajpheart.00692.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08491, KAKENHI-PROJECT-21K08105, KAKENHI-PROJECT-20K17081
[Journal Article] Effects of Elaidic Acid on HDL Cholesterol Uptake Capacity2021
- Author(s)
  Takuya Iino, Ryuji Toh, Manabu Nagao, Masakazu Shinohara, Amane Harada, Katsuhiro Murakami, Yasuhiro Irino, Makoto Nishimori, Sachiko Yoshikawa, Yutaro Seto, Tatsuro Ishida, Ken-Ichi Hirata
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 9 Pages: 3112-3112
- DOI
  10.3390/nu13093112
- NAID
  120007159890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08490
[Journal Article] Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation2020
- Author(s)
  Eriko Hisamatsu, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takuya Iino, Tetsuya Hara, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-ichi Hirata
- Journal Title
  
  Kobe J. Med. Sci
  
  Volume: 66
- NAID
  120006975804
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08490
[Journal Article] Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation2020
- Author(s)
  Eriko Hisamatsu, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takuya Iino, Tetsuya Hara, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata
- Journal Title
  
  Kobe J Med Sci .
  
  Volume: 66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08073
[Journal Article] Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation2020
- Author(s)
  Eriko Hisamatsu, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takuya Iino, Tetsuya Hara, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-ichi Hirata
- Journal Title
  
  Kobe Journal of Medical Sciences
  
  Volume: -
- NAID
  120006975804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08491
[Journal Article] Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study2020
- Author(s)
  Oshita T、Toh R、Nagano Y、Kuroda K、Nagasawa Y、Harada A、Murakami K、Kiriyama M、Yoshikawa K、Miwa K、Kubo T、Iino T、Nagao M、Irino Y、Hara T、Shinohara M、Otake H、Shinke T、Nakajima K、Ishida T、Hirata Ken-ichi
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 503 Pages: 136-144
- DOI
  10.1016/j.cca.2020.01.001
- NAID
  120006824021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08072, KAKENHI-PROJECT-18K08073, KAKENHI-PROJECT-19K08490, KAKENHI-PROJECT-17K09553
[Journal Article] A Novel Indicator for HDL Functionality2019
- Author(s)
  Irino Yasuhiro、Toh Ryuji、Ishida Tatsuro
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 26 Issue: 11 Pages: 945-946
- DOI
  10.5551/jat.ED111
- NAID
  130007740418
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08072, KAKENHI-PROJECT-19K08490
[Journal Article] Impaired Cholesterol‐Uptake Capacity of HDL Might Promote Target‐Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation2019
- Author(s)
  Nagano Y, Otake H, Toba T, Kuroda K, Shinkura Y, Tahara N, Tsukiyama Y, Yanaka K, Yamamoto H, Nagasawa A, Onishi H, Sugizaki Y, Takeshige R, Harada A, Murakami K, Kiriyama M, Oshita T, Irino Y, Kawamori H, Ishida T, Toh R, Shinke T, Hirata KI.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 8 Issue: 9
- DOI
  10.1161/jaha.119.011975
- NAID
  120006733129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08072, KAKENHI-PROJECT-17K09553, KAKENHI-PROJECT-18K08073
[Journal Article] Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease2019
- Author(s)
  Nagao Manabu、Miyashita Kazuya、Mori Kenta、Irino Yasuhiro、Toh Ryuji、Hara Tetsuya、Hirata Ken-ichi、Shinohara Masakazu、Nakajima Katsuyuki、Ishida Tatsuro
- Journal Title
  
  Journal of Clinical Lipidology
  
  Volume: 13 Issue: 5 Pages: 839-846
- DOI
  10.1016/j.jacl.2019.07.007
- NAID
  120007002630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08072, KAKENHI-PROJECT-18K08073, KAKENHI-PROJECT-17K09579
[Journal Article] Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties2018
- Author(s)
  6.Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata K
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 2 Pages: 596-601
- DOI
  10.1253/circj.CJ-17-0294
- NAID
  130006321869
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09121
[Journal Article] Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages2017
- Author(s)
  Tsuda Shigeyasu、Shinohara Masakazu、Oshita Toshihiko、Nagao Manabu、Tanaka Nobuaki、Mori Takeshige、Hara Tetsuya、Irino Yasuhiro、Toh Ryuji、Ishida Tatsuro、Hirata Ken-ichi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12989-12989
- DOI
  10.1038/s41598-017-13154-0
- NAID
  120006373799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01361, KAKENHI-PROJECT-15K09121
[Journal Article] Cholesterol Uptake Capacity: A New Measure of High-Density Lipoprotein Functionality for Coronary Risk Assessment.2017
- Author(s)
  Harada A, Toh R, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Kubo T, Irino Y, Tanaka N, Nishimura K, Ishida T, Hirata K.
- Journal Title
  
  Journal of Applied Laboratory Medicine.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09121
[Journal Article] Enhanced Impact of Cholesterol Absorption Marker on New Atherosclerotic Lesion Progression After Coronary Intervention During Statin Therapy2017
- Author(s)
  Mori K, Ishida T, Tsuda S, Oshita T, Shinohara M, Hara T, Irino Y, Toh R, Hirata KI.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 2 Pages: 123-132
- DOI
  10.5551/jat.32615
- NAID
  130005306526
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01361, KAKENHI-PROJECT-15K09121
[Journal Article] High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway2017
- Author(s)
  Nagao Manabu、Toh Ryuji、Irino Yasuhiro、Nakajima Hideto、Oshita Toshihiko、Tsuda Shigeyasu、Hara Tetsuya、Shinohara Masakazu、Ishida Tatsuro、Hirata Ken-ichi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 9 Pages: 1402-1409
- DOI
  10.1002/2211-5463.12279
- NAID
  120006373788
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01361, KAKENHI-PROJECT-15K09121
[Journal Article] The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography2017
- Author(s)
  Nagasawa Yoshinori、Shinke Toshiro、Toh Ryuji、Ishida Tatsuro、Otake Hiromasa、Takaya Tomofumi、Sugiyama Daisuke、Terashita Daisuke、Tahara Natsuko、Shinkura Yuto、Uzu Kenzo、Kashiwagi Daiji、Kuroda Koji、Nagano Yuichiro、Yamamoto Hiroyuki、Yanaka Kenichi、Tsukiyama Yoshiro、Hirata Ken-ichi
- Journal Title
  
  Atherosclerosis
  
  Volume: 265 Pages: 312-317
- DOI
  10.1016/j.atherosclerosis.2017.06.922
- NAID
  120006377646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08614, KAKENHI-PROJECT-15K09121
[Journal Article] Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia.2017
- Author(s)
  Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M
- Journal Title
  
  J Cardiol
  
  Volume: 印刷中 Issue: 2 Pages: 121-127
- DOI
  10.1016/j.jjcc.2016.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01361, KAKENHI-PROJECT-26461109, KAKENHI-PROJECT-15K21154, KAKENHI-PROJECT-15K09121
[Journal Article] β-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes.2016
- Author(s)
  Nagao M, Toh R, Irino Y, Mori T, Nakajima H, Hara T, Honjo T, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Hirata K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 475 Issue: 4 Pages: 322-328
- DOI
  10.1016/j.bbrc.2016.05.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21154
[Journal Article] 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.2016
- Author(s)
  Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1 Pages: 36749-36749
- DOI
  10.1038/srep36749
- NAID
  120005898711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01361, KAKENHI-PROJECT-26461070, KAKENHI-PROJECT-15K21154, KAKENHI-PROJECT-15K09081
[Journal Article] Comparison of telmisartan/amlodipine and telmisartan/hydrochlorothiazide in the treatment of Japanese patients with uncontrolled hypertension: the TAT-Kobe study.2016
- Author(s)
  Kondo K, Toh R, Ishida T, Mori K, Yasuda T, Hirata K.
- Journal Title
  
  Blood Press Monitoring
  
  Volume: 21 Issue: 3 Pages: 171-177
- DOI
  10.1097/mbp.0000000000000172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461070
[Journal Article] Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan2015
- Author(s)
  Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 9 Pages: 2017-2025
- DOI
  10.1253/circj.CJ-14-0750
- NAID
  130005095322
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460790, KAKENHI-PROJECT-26461109, KAKENHI-PROJECT-25461085
[Journal Article] LDL/HDLコレステロールを標的とした動脈硬化症の新しい治療ストラテジー. 機能不全HDLに対する治療戦略.2015
- Author(s)
  入野康宏, 石田達郎, 杜隆嗣.
- Journal Title
  
  血管医学
  
  Volume: 16 Pages: 53-60
- Data Source
  KAKENHI-PROJECT-15K09121
[Journal Article] Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia2014
- Author(s)
  Tanaka N, Ishida T, Nagao M, Mori T, Monguchi T, Sasaki M, Mori K, Kondo K, Nakajima H, Honjo T, Irino Y, Toh R, Shinohara M, Hirata K
- Journal Title
  
  Atherosclerosis
  
  Volume: 237 Issue: 2 Pages: 577-583
- DOI
  10.1016/j.atherosclerosis.2014.10.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591050, KAKENHI-PROJECT-25461085
[Journal Article] Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors.2014
- Author(s)
  Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K.
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 59 Issue: 4 Pages: 729-740
- DOI
  10.1002/mnfr.201400537
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461085, KAKENHI-PROJECT-25461129, KAKENHI-PROJECT-26461109, KAKENHI-PROJECT-15K09454, KAKENHI-PROJECT-25461448
[Journal Article] Endothelial lipase modulates pressure overload- induced heart failure through alternative pathway for fatty acid uptake2013
- Author(s)
  Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K.
- Journal Title
  
  Hypertension
  
  Volume: 61(5) Pages: 1002-7
- Data Source
  KAKENHI-PROJECT-23790852
[Journal Article] Endothelial Lipase Modulates Pressure Overload- Induced Heart Failure Through Alternative Pathway for Fatty Acid Uptake.2013
- Author(s)
  Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K
- Journal Title
  
  Hypertension
  
  Volume: 61(5) Issue: 5 Pages: 1002-7
- DOI
  10.1161/hypertensionaha.111.201608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590783, KAKENHI-PROJECT-24591050, KAKENHI-PROJECT-25461129, KAKENHI-PROJECT-25860602
[Journal Article] Pitavastatin increases HDL particles functionally-preserved with cholesterol efflux capacity and anti-oxidative action in dyslipidemia patients2013
- Author(s)
  Miyamoto-Sasak i M, Yasuda T , Monguchi T, Toh R, Ishida T, Hirata K.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: (掲載確定)
- Data Source
  KAKENHI-PROJECT-23790852
[Journal Article] Expression of endothelial lipase correlates with the size of neointima in a murine model of vascular remodeling2012
- Author(s)
  Sun L, Ishida T, Okada T, Yasuda T, Hara T, Toh R, Shinohara M, Yamashita T, Rikitake Y, Hirata K
- Journal Title
  
  Atheroscler Thromb
  
  Volume: 19 Pages: 1110-1127
- Data Source
  KAKENHI-PROJECT-23790852
[Journal Article] Expression of endothelial lipase correlates with the size of neointima in a murine model of vascular remodeling2012
- Author(s)
  Sun L, Ishida T, Okada T, Yasuda T, Hara T, Toh R, Shinohara M, Yamashita T, Rikitake Y, Hirata K.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 19 Pages: 1110-1127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790852
[Journal Article] 糖尿病性心筋障害におけるミトコンドリアの役割2007
- Author(s)
  杜隆嗣, 塩谷英之, 横山光宏
- Journal Title
  
  Diabetes Frontier 18
  
  Pages: 53-56
- Data Source
  KAKENHI-PROJECT-18790500
[Journal Article] eNOSと心不全2006
- Author(s)
  杜隆嗣, 川嶋成乃亮
- Journal Title
  
  分子心血管病 7
  
  Pages: 586-591
- Data Source
  KAKENHI-PROJECT-18790500
[Journal Article] An X-Ray diffraction study on mouse cardiac cross-bridge function in vivo : effects of adrenergic beta-stimulation.2006
- Author(s)
  Ryuji Toh, Masakazu Shinohara, Tomofumi Takaya, Tomoya Yamashita, Shigeru Masuda, Seinosuke Kawashima, Mitsuhiro Yokoyama, Naoto Yagi
- Journal Title
  
  Biophysical journal 90
  
  Pages: 1723-1728
- Data Source
  KAKENHI-PROJECT-18790500
[Patent] 抗酸化誘導剤および抗酸化誘導剤を併用する主治療薬のスクリーニング方法2016
- Inventor(s)
  杜　隆嗣、入野　康宏、平田　健一
- Industrial Property Rights Holder
  杜　隆嗣、入野　康宏、平田　健一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-136751
- Filing Date
  2016-07-11
- Data Source
  KAKENHI-PROJECT-15K09081
[Patent] 抗酸化誘導剤および抗酸化誘導剤を併用する主治療薬のスクリーニング方法2016
- Inventor(s)
  杜　隆嗣、入野　康宏、平田　健一
- Industrial Property Rights Holder
  杜　隆嗣、入野　康宏、平田　健一
- Industrial Property Rights Type
  特許
- Filing Date
  2016-07-11
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] Challenge to establish a novel HDL-directed prevention strategy in atherosclerosis2024
- Author(s)
  Ryuji Toh
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Invited
- Data Source
  KAKENHI-PROJECT-23K07506
[Presentation] Inhibition of Glutaminase1-dependent Glutaminolysis Improves Pathological Cardiac Remodeling2021
- Author(s)
  吉川　祥子*、長尾　学、杜　隆嗣、篠原　正和、飯野　琢也、西森　誠、入野　康宏、田中　秀和、小林　成美、石田　達郎、平田　健一
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08105
[Presentation] Inhibition of glutaminase1-mediated glutaminolysis ameliorates angiotensin II-induced cardiac remodeling2021
- Author(s)
  Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-21K08105
[Presentation] Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties2019
- Author(s)
  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Seimi Kobayashi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake,Tatsuro Ishida, Ken-ichi Hirata.
- Organizer
  第83回　日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08073
[Presentation] Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid2018
- Author(s)
  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Seimi Kobayashi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake,Tatsuro Ishida, Ken-ichi Hirata.
- Organizer
  American Heart Association Scientific Sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08073
[Presentation] Relationships between Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Morphologic Features of Coronary Plaque2018
- Author(s)
  Oshita T, Toh R, Ishida T, et al.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Understanding of HDL Cholesterol Efflux Capacity: Towards Clinical Application2018
- Author(s)
  Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第50回　日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08073
[Presentation] HDL機能の新規評価法“Cholesteroluptakecapacity”とOCT解析による冠動脈プラーク病変性状の比較検討2018
- Author(s)
  尾下寿彦、杜隆嗣、入野康宏、黒田浩史、永野雄一郎、長澤圭典、大竹寛雅、新家俊郎、石田達郎、平田健一
- Organizer
  第55回　日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08073
[Presentation] Searching for modulating factor of cholesterol uptake capacity, a novel indicator for HDL functionality2018
- Author(s)
  Toshihiko Oshita, Ryuji Toh,Mitsumasa Okano, Shigeyasu Tsuda, Koichi Watanabe, Seimi Kobayashi, Tetsuya Hara, Masakazu Shinohara, Yasuhiro Irino, Katsuhiro Murakami, Amane Harada, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第50回　日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08073
[Presentation] Identification of Determinants of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality2018
- Author(s)
  Oshita T, Toh R, Ishida T, et al.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Association of Coronary Lipidic Plaque Burden with Impairment of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality: OCT-based Observation Study2017
- Author(s)
  Oshita T, Toh R, Ishida T, et al.
- Organizer
  American Heart Association Scientific sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Inverse Association Between HDL Cholesterol Uptake Capacity And Coronary Atherosclerotic Burden: OCT-based Observation Study2017
- Author(s)
  Toshihiko Oshita, Ryuji Toh, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Kenta Mori, Yasuhiro Irino, Hiromasa Otake, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第81回　日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Clinical and Practical Assessment of Dysfunctional HDL in Cardiovascular Risk Stratification2017
- Author(s)
  Tatsuro Ishida, Ryuji Toh, Hiromasa Otake, Toshiro Shinke, Amane Harada, Ken-ichi Hirata
- Organizer
  第81回　日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] 2-aminobutyric acid as a newly identified modulator of glutathione homeostasis in failing myocardium2017
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Hidekazu Tanaka, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第8１回　日本循環器学会　学術集会
- Place of Presentation
  金沢　日本
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09081
[Presentation] Impaired HDL-cholesterol uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stenting2017
- Author(s)
  永野雄一朗、大竹寛雅、入野康宏、鳥羽敬義、高橋八大、寺下大輔、黒田浩史、宇津賢三、田原奈津子、新倉悠人、長澤圭典、築山義朗、谷仲謙一、山本裕之、新家俊郎、原田周、村上克洋、石田達郎、杜隆嗣、平田健一
- Organizer
  第81回　日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] 2-aminobutyric acid as a newly identified modulator of glutathione homeostasis in failing myocardium2017
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Hidekazu Tanaka, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第81回　日本循環器学会　学術集会
- Place of Presentation
  金沢　日本
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] Cholesterol uptake capacity, a new concept of HDL functionality, for risk stratification in coronary artery disease2016
- Author(s)
  Toh R, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Irino Y, Mori K, Tanaka N, Nishimura K, Ishida T, Hirata K.
- Organizer
  68th AACC Annual Scientific Meeting & Clinical Lab Expo
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2016-08-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] HDL粒子によるコレステロール引抜き/取込み能と冠動脈疾患との関係2016
- Author(s)
  Toh R,, Ishida T,Harada A, Yoshida T, Hirata K.
- Organizer
  第64回日本心臓病学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-09-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Elevated beta-hydroxybutyrate due to downregulation of SCOT exerts cardioprotective effects in failing hearts2016
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, and Ken-ichi Hirata
- Organizer
  第80回　日本循環器学会　学術集会
- Place of Presentation
  仙台　日本
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K09081
[Presentation] 高比重リポ蛋白 (HDL) の抗炎症効果はリン脂質構成に依存する2016
- Author(s)
  Tanaka N, Irino Y, Shinohara M, Tsuda S, Nagao M, Mori K, Mori T, Hara T, Toh R, Ishida T, Hirata K.
- Organizer
  第48回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Endothelial Lipase Regulates Plasma HDL-C Concentration without　Affecting Cholesterol Uptake Capacity of HDL Particle in Patients with　Coronary Artery Disease.2016
- Author(s)
  Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Takuya Kubo, Keiko Miwa, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第80回　日本循環器学会　学術集会
- Place of Presentation
  仙台　日本
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Cholesterol Uptake Capacity, a New Measure for High-Density Lipoprotein Functionality And Its Association with Incident Cardiovascular Events.2016
- Author(s)
  Harada A, Toh R, Murakami K, Kiriyama M, Yoshikawa K, Kubo T, Miwa K, Irino Y, Mori K, Tanaka N, Ishida T, Hirata K.
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Cholesterol Uptake Capacity, a New Measure for High-Density Lipoprotein Functionality And Its Association with Incident Cardiovascular Events2016
- Author(s)
  Toshihiko Oshita, Tetsuya Hara, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Yasuhiro Irino, Kenta Mori, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第80回　日本循環器学会　学術集会
- Place of Presentation
  仙台　日本
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Elevated beta-hydroxybutyrate due to downregulation of SCOT exerts cardioprotective effects in failing hearts2016
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, and Ken-ichi Hirata
- Organizer
  The ８０th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  仙台　日本
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] Cholesterol Uptake Capacity: A New Measure of HDL Functionality for Coronary Risk Stratification2016
- Author(s)
  Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Kunihiro Nishimura, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第33回　ISHR日本部会総会
- Place of Presentation
  東京
- Year and Date
  2016-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] 2-Aminobutyric acid reflects myocardial redox state in doxorubicin-induced cardiomyopathy2015
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Masakazu Shinohara, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  11th International Conference of the Metabolomics Society (Metabolomics 2015)
- Place of Presentation
  サンフランシスコ　米国
- Year and Date
  2015-06-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] 冠動脈疾患二次予防における予測因子としての血清ミエロペルオキシダーゼ/パラオキソナーゼ1比の有用性についての検討2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  第15回日本NO学会
- Place of Presentation
  大阪
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  第47回日本動脈硬化学会総会学術集会
- Place of Presentation
  仙台　日本
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Serum myeloperoxidase/paraoxonase 1 ration predicts recurrent coronary artery disease2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  ATVB PVD 2015 Scientific Sessions
- Place of Presentation
  サンフランシスコ　米国
- Year and Date
  2015-05-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  第47回日本動脈硬化学会総会学術集会
- Place of Presentation
  仙台
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] Serum myeloperoxidase/paraoxonase 1 ration predicts recurrent coronary artery disease2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  ATVB/PVD2015
- Place of Presentation
  サンフランシスコ、アメリカ
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09121
[Presentation] 2-Aminobutyric acid reflects myocardial redox state in doxorubicin-induced cardiomyopathy2015
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Masakazu Shinohara, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  11th International Conference of the Metabolomics Society (Metabolomics 2015)
- Place of Presentation
  サンフランシスコ　米国
- Year and Date
  2015-06-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09081
[Presentation] 冠動脈疾患二次予防における予測因子としての血清ミエロペルオキシダーゼ/パラオキソナーゼ1比の有用性についての検討2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  第15回日本NO学会
- Place of Presentation
  大阪　日本
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Feasibility of 2-Aminobutyric acid as a biomarker for early detection of doxorubicin-induced cardiotoxicity2015
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Masakazu Shinohara, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  The 79th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  大阪　日本
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] Impact of Serum Myeloperoxidase/Paraoxonase 1 Ratio as a Predictive Marker of for Secondary Prevention of Coronary Artery Disease2015
- Author(s)
  Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
- Organizer
  第79回　日本循環器学会　学術集会
- Place of Presentation
  大阪　日本
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Feasibility of 2-Aminobutyric acid as a biomarker for early detection of doxorubicin-induced cardiotoxicity2015
- Author(s)
  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Masakazu Shinohara, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
- Organizer
  第79回　日本循環器学会　学術集会
- Place of Presentation
  大阪　日本
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09081
[Presentation] Trans fatty acids increase inflammatory cytokines in plasma and aorta and decrease fatty acid elongation in LDL receptor knockout mice2013
- Author(s)
  Hasokawa M, Shinohara M, Yasuda T, Toh R, Ishida T, Hirata K
- Organizer
  第77回日本循環器学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-23790852
[Presentation] Trans-fatty acid accelerates thrombus formation in vivo through aggravating anti-thrombogenic phenotype of vascular endothelial cells.2013
- Author(s)
  Kensuke Kondo, Tatsuro Ishida, Tomoyuki Yasuda, Junichiro Yamamoto, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Kenta Mori, Hideto Nakajima, Ryuji Toh, Kenichi Hirata.
- Organizer
  Amerikan Heart Association Scientifi Sessions 2013
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-25461129
[Presentation] Trans fatty acid is a modulator of serum lipoprotein metabolism and coronary artery disease in Japanese subjects2012
- Author(s)
  破磯川実、篠原正和、門口倫子、佐々木真希、近藤健介、森健太、中島英人、原口英子、安田知行、杜隆嗣、石田達郎、平田健一
- Organizer
  第44回日本動脈硬化学会総会
- Place of Presentation
  福岡
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-23790852
[Presentation] Myeloperoxidase and paraoxonase 1 modulate functional quality of HDL and progression of coronary artery lesions2012
- Author(s)
  Haraguchi Y, Toh R, Ishida T, Monguchi T,Sasaki M, Mori K,Kondo K, Hasokawa M,Nakajima H, Hirata K
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles, CA, USA
- Year and Date
  2012-11-07
- Data Source
  KAKENHI-PROJECT-23790852
[Presentation] Cardiac endothelial lipase expression is augmented in a murine model of heart failure2012
- Author(s)
  Hideto Nakajima, Tatsuro Ishida, Monguchi Tomoko, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Sun Li, Tomoyuki Yasuda, Shinohara Masakazu, Toh Ryuji, Seimi Kobayashi, Ken-ichi Hirata
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22590783
[Presentation] Fasting serum concentration of apolipoprotein B48 is a putative predictor of coronary risk in patients with coronary artery disease2012
- Author(s)
  森健太、石田達郎、門口倫子、佐々木真希、近藤健介、破磯川実、中島英人、原口英子、杜隆嗣、安田知行、篠原正和、西村邦弘、平田健一
- Organizer
  第44回日本動脈硬化学会総会
- Place of Presentation
  福岡
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-23790852
[Presentation] Endothelial lipase in the heart modulates pressure overload-induced heart failure through fatty acid utilization.2012
- Author(s)
  Hideto Nakajima, Tatsuro Ishida, Michiko Monguchi, Maki Sasaki, KensukeKondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Ryuji Toh, Seimi Kobayashi, Ken-ichi Hirata
- Organizer
  American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles, CA, USA.
- Year and Date
  2012-11-07
- Data Source
  KAKENHI-PROJECT-22590783
[Presentation] Role of ndothelial lipase in HDL metabolism and atherosclerosis in humans2011
- Author(s)
  Ishida T, Toh R, Sun L, Yasuda T, Hirata K
- Organizer
  79th European Atherosclerosis Society Congress
- Place of Presentation
  Gothenburg, Sweden.
- Year and Date
  2011-06-28
- Data Source
  KAKENHI-PROJECT-23790852
[Presentation] Pressure-overload Induced Hypertrophied Hearts Displayed Regional Diffe rences in Cross-bridge Dynamics: Evidence from X-Ray Diffraction Study Using Synchrotron Radiation2008
- Author(s)
  杜隆嗣
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  日本、福岡県
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-18790500
[Presentation] Myofilament Disarray in a Failing Heart of the MLP-deficient Mouse:Evidence from X-Ray Diffraction Study Using Synchrotron Radiation2007
- Author(s)
  杜隆嗣
- Organizer
  第11回日本心不全学会学術集会
- Place of Presentation
  日本、千葉県
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-18790500
[Presentation] 機能不全HDLマーカーとしての血清MPO/PON1比の有用性
- Author(s)
  杜　隆嗣
- Organizer
  第43回日本心脈管作動物質学会総会
- Place of Presentation
  神戸　日本
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] GCMSを用いた心不全バイオマーカー探索
- Author(s)
  Yasuhiro Irino, Ryuji Toh, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Tatsuro Ishida, Okiko Miyata, and Ken-ichi Hirata
- Organizer
  第39回日本医用マススペクトル学会年会
- Place of Presentation
  千葉　日本
- Year and Date
  2014-10-16 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] 機能不全HDLの簡便な臨床評価法としての血清MPO/PON1比測定の有用性
- Author(s)
  杜　隆嗣、石田　達郎、西村　邦宏、平田　健一
- Organizer
  第111回　日本内科学会総会
- Place of Presentation
  東京　日本
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] 心不全における新たなバイオマーカーとしての2-Aminobutyric acidの可能性
- Author(s)
  Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Tatsuro Ishida, Okiko Miyata, and Ken-ichi Hirata
- Organizer
  第18回　日本心不全学会学術集会
- Place of Presentation
  大阪　日本
- Year and Date
  2014-10-10 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26461070
[Presentation] Oral administration of eicosapentaenoic acid ameliorates anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients
- Author(s)
  Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  シカゴ　アメリカ
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Eicosapentaenoic acid improves anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients
- Author(s)
  Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata
- Organizer
  第46回日本動脈硬化学会総会
- Place of Presentation
  東京　日本
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] 心不全における新たなバイオマーカーとしての2-Aminobutyric acidの可能性
- Author(s)
  杜　隆嗣
- Organizer
  第18回　日本心不全学会学術集会
- Place of Presentation
  大阪　日本
- Year and Date
  2014-10-10 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-25860602
[Presentation] Inflammation-Activated Angptl3-Endothelial Lipase System Regulates Serum HDL-C Levels in Acute Coronary Syndrome
- Author(s)
  Kenta Mori, Tatsuro Ishida, Kazuya miyashita, Noriaki Kinoshita, Hideto Nakajima, Tomoyuki Yasuda, Ryuji Toh, Masahito Kawata, Susumu Sakamoto, Katsuyuki Nakajima, Ken-ichi Hirata.
- Organizer
  第46回日本動脈硬化学会総会
- Place of Presentation
  東京　日本
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25461085
[Presentation] Circulating levels of 2-Aminobutyric acid reflect myocardial redox state in patients with atrial septal defects
- Author(s)
  Yasuhiro Irino, Ryuji Toh, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Tatsuro Ishida, Okiko Miyata, and Ken-ichi Hirata
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  シカゴ　アメリカ
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461070

1. ISHIDA Tatsuro (00379413)

# of Collaborated Projects: 7 results

# of Collaborated Products: 26 results
2. HIRATA KEN-ICHI (20283880)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
3. TANAKA Hidekazu (20590342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. SHINOHARA MASAKAZU (80437483)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. KAWAI Hiroya (20346266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. SHINKE TOSHIRO (60379419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 長尾学 (70866029)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. Fukuzawa Koji (70535856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Hideto Nakajima (70726992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Takaya Tomofumi (60714665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Irino Yasuhiro (10415565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. Satomi-Kobayashi Seimi (20379415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 原哲也 (70547504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 多田隼人 (90623653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOH RYUJI 杜 隆嗣

TOH Ryuji 杜 隆嗣

杜 隆嗣 トウ リュウジ

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新たなHDL機能指標による高HDLコレステロール血症におけるリスク評価法の構築Principal Investigator

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Clinical utility of cholesterol uptake capacity, a novel indicator for HDL functionalityPrincipal Investigator

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Metabolomic Identification of Novel Regulators of Cardiac Oxidative Stress in Heart FailurePrincipal Investigator

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TOH RYUJI 杜隆嗣

TOH Ryuji 杜隆嗣

杜隆嗣トウリュウジ

[Book] 2-アミノ酪酸による体内酸化防止機能　～新たなグルタチオン代謝制御機構の発見～2017