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OHASHI WAKANA  大橋 若奈

ORCIDConnect your ORCID iD *help
Researcher Number 50381596
Other IDs
Affiliation (Current) 2022: 慶應義塾大学, 薬学部(芝共立), 特任講師
Affiliation (based on the past Project Information) *help 2020: 慶應義塾大学, 薬学部(芝共立), 特任講師
2019: 富山大学, 学術研究部医学系, 助教
2013 – 2018: 富山大学, 大学院医学薬学研究部(医学), 助教
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
General pharmacology
Keywords
Principal Investigator
亜鉛 / 亜鉛トランスポーター / 腸管上皮細胞 / 腸管上皮幹細胞 / 大腸がん / 悪性腫瘍 / 亜鉛生物学 / 消化管 / ER / 幹細胞 … More / トランスポーター / 小胞体ストレス / 腸管恒常性 / 腸上皮細胞 / がん細胞 / 腸上皮幹細胞 / 大腸 … More
Except Principal Investigator
敗血症 / GRK2 / 炎症性サイトカイン / 活性酸素 / 敗血症性脳症 / ミクログリア / iNOS / β-Arrestin2 / 播種性血管内凝固 / 転写因子 / 薬理学 / 転与因子 Less
  • Research Projects

    (6 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (17 People)
  •  亜鉛トランスポーターを介した代謝制御機構の解明に基づく大腸がん治療戦略の創出Principal Investigator

    • Principal Investigator
      大橋 若奈
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Keio University
  •  Prophylactic and therapeutic strategy based on the molecular pathology of septic disseminated intravascular coagulation (DIC)

    • Principal Investigator
      HATTORI Yuichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Health Sciences University of Hokkaido
      University of Toyama
  •  Studies of Zinc transporter detected in tumor lesions as a target for cancer therapyPrincipal Investigator

    • Principal Investigator
      Ohashi Wakana
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Elucidation of the role of Zinc transporter in intestinal stem cell maintenance.Principal Investigator

    • Principal Investigator
      Ohashi Wakana
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
  •  Studies on GRK2 as a potential drug discovery target for the sepsis syndrome

    • Principal Investigator
      Hattori Yuichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      University of Toyama
  •  The role of Zinc transporter in maintacnce of stemness of intestinal epithelial stem cellPrincipal Investigator

    • Principal Investigator
      OHASHI WAKANA
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020

    • Author(s)
      大橋若奈、 井村穣二
    • Journal Title

      細胞

      Volume: 3 Pages: 36-39

    • NAID

      40022309354

    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020

    • Author(s)
      大橋若奈、 井村穣二
    • Journal Title

      アグリバイオ

      Volume: 5 Pages: 67-71

    • NAID

      40022309354

    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Journal Article] Regulatory role of GRK2 in the TLR signaling-mediated iNOS induction pathway in microglial cells2019

    • Author(s)
      Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y.
    • Journal Title

      Front. Pharmacol.

      Volume: - Pages: 59-59

    • DOI

      10.3389/fphar.2019.00059

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Journal Article] Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases2019

    • Author(s)
      Ohashi W., T. Fukada
    • Journal Title

      J. Immunol. Res

      Volume: - Pages: 1-11

    • DOI

      10.1155/2019/8396878

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04011, KAKENHI-PROJECT-17K09373
  • [Journal Article] Maintenance of intestinal epithelial homeostasis by zinc transporters2019

    • Author(s)
      Ohashi W., T. Hara, T. Takagishi., K. Hase, T. Fukada
    • Journal Title

      Dig. Dis. Sci.

      Volume: 64 Pages: 2404-2415

    • DOI

      10.1007/s10620-019-05561-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04011, KAKENHI-PROJECT-17K09373
  • [Journal Article] Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways2018

    • Author(s)
      Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y
    • Journal Title

      Int Immunopharmacol

      Volume: 62 Pages: 121-131

    • DOI

      10.1016/j.intimp.2018.06.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08586
  • [Journal Article] SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex2017

    • Author(s)
      Ohashi W, Yamamine N, Imura J, Hattori Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 493 Pages: 1342-1348

    • DOI

      10.1016/j.bbrc.2017.09.161

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Journal Article] Emerging role of zinc homeostasis by zinc transporter ZIP7 in intestinal homeostatic self-renewal2017

    • Author(s)
      Ohashi W, Hase K, Fukada T.
    • Journal Title

      Inflammation & Cell signaling

      Volume: 4

    • DOI

      10.14800/ics.1509

    • Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19319
  • [Journal Article] Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress2016

    • Author(s)
      Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irie, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K., Fukada, T.
    • Journal Title

      PLoS Genet.

      Volume: 12

    • DOI

      10.1371/journal.pgen.1006349

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01279, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K11459, KAKENHI-PROJECT-16K08457, KAKENHI-PROJECT-16K15294, KAKENHI-PUBLICLY-16H01369
  • [Journal Article] Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis2016

    • Author(s)
      Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y.
    • Journal Title

      Int. Care Med. Exp.

      Volume: 4 Pages: 36-36

    • DOI

      10.1186/s40635-016-0109-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-16K08200, KAKENHI-PROJECT-16K08231
  • [Journal Article] 腸管恒常性における亜鉛トランスポーターの役割 “The role of Zinc transporter in the maintenance of intestinal epithelial homeostasis”2016

    • Author(s)
      大橋若奈
    • Journal Title

      亜鉛栄養治療

      Volume: 7 Pages: 22-34

    • Data Source
      KAKENHI-PROJECT-15K19319
  • [Journal Article] Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation.2015

    • Author(s)
      Wakana Ohashi, Kohshi Hattori, Yuichi Hattori
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: 354巻,3号 Pages: 240-250

    • DOI

      10.1124/jpet.115.225540

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460336, KAKENHI-PROJECT-15K19319
  • [Journal Article] Control of macrophage dynamics as a potential therapeutic approach for clinical disorders involving chronic inflammation2015

    • Author(s)
      Wakana Ohashi, Kohshi Hattori, Yuichi Hattori
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: x

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860573
  • [Journal Article] GRK2 as a potential therapeutic target for septic ARDS2015

    • Author(s)
      大橋若奈,服部裕一
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 145 Issue: 3 Pages: 122-128

    • DOI

      10.1254/fpj.145.122

    • NAID

      130004827732

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-26460336
  • [Journal Article] Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages.2015

    • Author(s)
      Qiang Wang, Hiroki Yokoo, Michinori Takashina, Kimimasa Sakata, Wakana Ohashi, Lobna A Abdelzaher, Takahiro Imaizumi, Takuya Sakamoto, Kohshi Hattori, Naoyuki Matsuda, Yuichi Hattori
    • Journal Title

      Brit Care Med

      Volume: 43巻,11号

    • DOI

      10.1097/ccm.0000000000001269

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460336, KAKENHI-PROJECT-15K15661, KAKENHI-PROJECT-25293365
  • [Presentation] 大腸がんの腫瘍形成に関わる亜鉛トランスポーターZIP72020

    • Author(s)
      大橋若奈、仙田幸音、洞口龍介、井村穣二
    • Organizer
      第142回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-20K08354
  • [Presentation] 腫瘍形成における亜鉛トランスポーターの機能2020

    • Author(s)
      仙田幸音、大橋若奈、洞口龍介、井村穣二
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K08354
  • [Presentation] 大腸癌おける亜鉛トランスポーターZIP7と移動・転移能の獲得/腫瘍性質との関わり2020

    • Author(s)
      仙田 幸音、大橋 若奈、洞口 龍介、サイリシパリキヒ、下村 明子、住吉 紗代子、井村 穣二
    • Organizer
      第66回日本病理学会秋期特別総会
    • Data Source
      KAKENHI-PROJECT-20K08354
  • [Presentation] 亜鉛トランスポーターZIP7によるがん細胞形質の悪性化2020

    • Author(s)
      仙田幸音、大橋若奈、洞口龍介、井村穣二
    • Organizer
      第38回日本生化学会北陸支部会
    • Data Source
      KAKENHI-PROJECT-20K08354
  • [Presentation] 亜鉛トランスポーターZIP7ががん細胞性へ及ぼす影響についての検討2019

    • Author(s)
      洞口龍介、大橋若奈、山峯直樹、服部裕一
    • Organizer
      第18回日本亜鉛栄養治療研究会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] Zinc transporter ZIP7 regulates tumorigenic potential in human colorectal cancer cells2019

    • Author(s)
      Wakana Ohashi, Ryusuke Horaguchi, and Yuichi Hattori
    • Organizer
      第92回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] がん細胞における亜鉛トランスポーターZIP7の役割の解析2019

    • Author(s)
      洞口龍介、大橋若奈、山峯直樹、服部裕一
    • Organizer
      日本生化学会第37回北陸支部会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] Contribution of Zinc transporter in the tumorigenic potentials of human colorectal cancer cells2019

    • Author(s)
      Wakana Ohashi, Ryusuke Horaguchi, Naoki Yamamine, and Yuichi Hattori
    • Organizer
      International Society of Zinc Biology 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] Zinc transporter SLC39A7/ZIP7 is essential for intestinal homeostatic self-renewal2018

    • Author(s)
      Wakana Ohashi, Koji Hase, Toshiyuki Fukada
    • Organizer
      18th World Congress of Basic ad Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] Zinc transporter SLC39A7/ZIP7 contributes to the tumorigenic potentials of human colorectal cancer cells2018

    • Author(s)
      Ryusuke Horaguchi, Wakana Ohashi, Naoki Yamamine, Tetsuro Oda, and Yuichi Hattori
    • Organizer
      18th World Congress of Basic ad Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 大腸がんにおけるWntアゴニストSKL2001の増殖制御機構の解析2018

    • Author(s)
      大橋若奈、山峯直樹、井村穣二、服部裕一
    • Organizer
      第90回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 腸上皮恒常性維持における亜鉛トランスポーターZIP7の役割2018

    • Author(s)
      大橋若奈、長谷耕二、深田俊幸
    • Organizer
      第29回日本微量元素学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 腸上皮恒常性における亜鉛トランスポーターZIP7の役割2017

    • Author(s)
      大橋若奈、長谷耕二、深田俊幸
    • Organizer
      第12回トランスポーター研究会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] Role of the zinc transporter SLC39A7/ZIP7 in intestinal homeostatic self-renewal2017

    • Author(s)
      Wakana Ohashi, Koji Hase, and Toshiyuki Fukada.
    • Organizer
      International Society for the ISZB meeting 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 亜鉛トランスポーター ZIP7 による腸管上皮恒常性維持機構2017

    • Author(s)
      大橋 若奈、長谷 耕二、深田 俊幸、服部 裕一
    • Organizer
      第68回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 亜鉛トランスポーターZIP7の大腸がんにおける機能解析2017

    • Author(s)
      山峯 直樹、大橋 若奈、織田 哲郎、洞口 龍介、服部 裕一
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 大腸がんにおける亜鉛トランスポーター ZIP7 の役割2017

    • Author(s)
      山峯 直樹、大橋 若奈、織田 哲郎、洞口 龍介、服部 裕一
    • Organizer
      第68回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-17K09373
  • [Presentation] 亜鉛トランスポーターによる小胞体ストレスと腸管上皮恒常性の制御機構2016

    • Author(s)
      Wakana Ohashi, Koji Hase, Toshiyuki Fukada
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K19319
  • [Presentation] 腸管上皮の自己複製機構における亜鉛トランスポーターの役割2016

    • Author(s)
      大橋若奈、長谷耕二、深田俊幸
    • Organizer
      第93回日本生理学会大会 シンポジウム14
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15K19319
  • [Presentation] 腸管恒常性における亜鉛トランスポーターの役割2016

    • Author(s)
      大橋若奈
    • Organizer
      第13回 亜鉛栄養治療研究会
    • Place of Presentation
      大阪新丸ビル
    • Year and Date
      2016-08-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19319
  • 1.  Hattori Yuichi (50156361)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 2.  井村 穣二 (80316554)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 3.  冨田 賢吾 (20758213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  鈴木 登紀子 (10415531)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  早川 芳弘 (10541956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KIMURA Tohru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  KIMURA Shunsuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  森 寿
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  佐藤 俊朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  深田 俊幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 11.  美島 健二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  入江 太朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  長谷 耕二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  大津 浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  轟木 堅一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  田中 智之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  松田 直之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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