OHASHI WAKANA 大橋若奈

Researcher Number	50381596
Other IDs
Affiliation (Current)	2022: 慶應義塾大学, 薬学部(芝共立), 特任講師
Affiliation (based on the past Project Information) *help	2020: 慶應義塾大学, 薬学部(芝共立), 特任講師 2019: 富山大学, 学術研究部医学系, 助教 2013 – 2018: 富山大学, 大学院医学薬学研究部(医学), 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator General pharmacology
Keywords	Principal Investigator 亜鉛 / 亜鉛トランスポーター / 腸管上皮細胞 / 腸管上皮幹細胞 / 大腸がん / 悪性腫瘍 / 亜鉛生物学 / 消化管 / ER / 幹細胞 … More / トランスポーター / 小胞体ストレス / 腸管恒常性 / 腸上皮細胞 / がん細胞 / 腸上皮幹細胞 / 大腸 … More Except Principal Investigator 敗血症 / GRK2 / 炎症性サイトカイン / 活性酸素 / 敗血症性脳症 / ミクログリア / iNOS / β-Arrestin2 / 播種性血管内凝固 / 転写因子 / 薬理学 / 転与因子 Less

亜鉛トランスポーターを介した代謝制御機構の解明に基づく大腸がん治療戦略の創出Principal Investigator
- Principal Investigator
  
  大橋若奈
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Keio University
Prophylactic and therapeutic strategy based on the molecular pathology of septic disseminated intravascular coagulation (DIC)
- Principal Investigator
  
  HATTORI Yuichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Health Sciences University of Hokkaido
  University of Toyama
Studies of Zinc transporter detected in tumor lesions as a target for cancer therapyPrincipal Investigator
- Principal Investigator
  
  Ohashi Wakana
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Toyama
Elucidation of the role of Zinc transporter in intestinal stem cell maintenance.Principal Investigator
- Principal Investigator
  
  Ohashi Wakana
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Toyama
Studies on GRK2 as a potential drug discovery target for the sepsis syndrome
- Principal Investigator
  
  Hattori Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Toyama
The role of Zinc transporter in maintacnce of stemness of intestinal epithelial stem cellPrincipal Investigator
- Principal Investigator
  
  OHASHI WAKANA
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Toyama

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020
- Author(s)
  大橋若奈、　井村穣二
- Journal Title
  
  細胞
  
  Volume: 3 Pages: 36-39
- NAID
  40022309354
- Data Source
  KAKENHI-PROJECT-17K09373
[Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020
- Author(s)
  大橋若奈、　井村穣二
- Journal Title
  
  アグリバイオ
  
  Volume: 5 Pages: 67-71
- NAID
  40022309354
- Data Source
  KAKENHI-PROJECT-17K09373
[Journal Article] Regulatory role of GRK2 in the TLR signaling-mediated iNOS induction pathway in microglial cells2019
- Author(s)
  Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y.
- Journal Title
  
  Front. Pharmacol.
  
  Volume: - Pages: 59-59
- DOI
  10.3389/fphar.2019.00059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09373
[Journal Article] Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases2019
- Author(s)
  Ohashi W., T. Fukada
- Journal Title
  
  J. Immunol. Res
  
  Volume: - Pages: 1-11
- DOI
  10.1155/2019/8396878
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04011, KAKENHI-PROJECT-17K09373
[Journal Article] Maintenance of intestinal epithelial homeostasis by zinc transporters2019
- Author(s)
  Ohashi W., T. Hara, T. Takagishi., K. Hase, T. Fukada
- Journal Title
  
  Dig. Dis. Sci.
  
  Volume: 64 Pages: 2404-2415
- DOI
  10.1007/s10620-019-05561-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04011, KAKENHI-PROJECT-17K09373
[Journal Article] Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways2018
- Author(s)
  Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 62 Pages: 121-131
- DOI
  10.1016/j.intimp.2018.06.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08586
[Journal Article] SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex2017
- Author(s)
  Ohashi W, Yamamine N, Imura J, Hattori Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 493 Pages: 1342-1348
- DOI
  10.1016/j.bbrc.2017.09.161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09373
[Journal Article] Emerging role of zinc homeostasis by zinc transporter ZIP7 in intestinal homeostatic self-renewal2017
- Author(s)
  Ohashi W, Hase K, Fukada T.
- Journal Title
  
  Inflammation & Cell signaling
  
  Volume: ４
- DOI
  10.14800/ics.1509
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19319
[Journal Article] Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress2016
- Author(s)
  Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irie, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K., Fukada, T.
- Journal Title
  
  PLoS Genet.
  
  Volume: 12
- DOI
  10.1371/journal.pgen.1006349
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01279, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K11459, KAKENHI-PROJECT-16K08457, KAKENHI-PROJECT-16K15294, KAKENHI-PUBLICLY-16H01369
[Journal Article] Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis2016
- Author(s)
  Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y.
- Journal Title
  
  Int. Care Med. Exp.
  
  Volume: ４ Pages: 36-36
- DOI
  10.1186/s40635-016-0109-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-16K08200, KAKENHI-PROJECT-16K08231
[Journal Article] 腸管恒常性における亜鉛トランスポーターの役割 “The role of Zinc transporter in the maintenance of intestinal epithelial homeostasis”2016
- Author(s)
  大橋若奈
- Journal Title
  
  亜鉛栄養治療
  
  Volume: 7 Pages: 22-34
- Data Source
  KAKENHI-PROJECT-15K19319
[Journal Article] Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation.2015
- Author(s)
  Wakana Ohashi, Kohshi Hattori, Yuichi Hattori
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 354巻，3号 Pages: 240-250
- DOI
  10.1124/jpet.115.225540
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460336, KAKENHI-PROJECT-15K19319
[Journal Article] Control of macrophage dynamics as a potential therapeutic approach for clinical disorders involving chronic inflammation2015
- Author(s)
  Wakana Ohashi, Kohshi Hattori, Yuichi Hattori
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860573
[Journal Article] GRK2 as a potential therapeutic target for septic ARDS2015
- Author(s)
  大橋若奈，服部裕一
- Journal Title
  
  Folia Pharmacol. Jpn.
  
  Volume: 145 Issue: 3 Pages: 122-128
- DOI
  10.1254/fpj.145.122
- NAID
  130004827732
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26460336
[Journal Article] Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages.2015
- Author(s)
  Qiang Wang, Hiroki Yokoo, Michinori Takashina, Kimimasa Sakata, Wakana Ohashi, Lobna A Abdelzaher, Takahiro Imaizumi, Takuya Sakamoto, Kohshi Hattori, Naoyuki Matsuda, Yuichi Hattori
- Journal Title
  
  Brit Care Med
  
  Volume: 43巻，11号
- DOI
  10.1097/ccm.0000000000001269
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460336, KAKENHI-PROJECT-15K15661, KAKENHI-PROJECT-25293365
[Presentation] 大腸がんの腫瘍形成に関わる亜鉛トランスポーターZIP72020
- Author(s)
  大橋若奈、仙田幸音、洞口龍介、井村穣二
- Organizer
  第142回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K08354
[Presentation] 腫瘍形成における亜鉛トランスポーターの機能2020
- Author(s)
  仙田幸音、大橋若奈、洞口龍介、井村穣二
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K08354
[Presentation] 大腸癌おける亜鉛トランスポーターZIP7と移動・転移能の獲得/腫瘍性質との関わり2020
- Author(s)
  仙田幸音、大橋若奈、洞口龍介、サイリシパリキヒ、下村明子、住吉紗代子、井村穣二
- Organizer
  第66回日本病理学会秋期特別総会
- Data Source
  KAKENHI-PROJECT-20K08354
[Presentation] 亜鉛トランスポーターZIP7によるがん細胞形質の悪性化2020
- Author(s)
  仙田幸音、大橋若奈、洞口龍介、井村穣二
- Organizer
  第38回日本生化学会北陸支部会
- Data Source
  KAKENHI-PROJECT-20K08354
[Presentation] 亜鉛トランスポーターZIP7ががん細胞性へ及ぼす影響についての検討2019
- Author(s)
  洞口龍介、大橋若奈、山峯直樹、服部裕一
- Organizer
  第18回日本亜鉛栄養治療研究会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] Zinc transporter ZIP7 regulates tumorigenic potential in human colorectal cancer cells2019
- Author(s)
  Wakana Ohashi, Ryusuke Horaguchi, and Yuichi Hattori
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] がん細胞における亜鉛トランスポーターZIP7の役割の解析2019
- Author(s)
  洞口龍介、大橋若奈、山峯直樹、服部裕一
- Organizer
  日本生化学会第37回北陸支部会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] Contribution of Zinc transporter in the tumorigenic potentials of human colorectal cancer cells2019
- Author(s)
  Wakana Ohashi, Ryusuke Horaguchi, Naoki Yamamine, and Yuichi Hattori
- Organizer
  International Society of Zinc Biology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] Zinc transporter SLC39A7/ZIP7 is essential for intestinal homeostatic self-renewal2018
- Author(s)
  Wakana Ohashi, Koji Hase, Toshiyuki Fukada
- Organizer
  18th World Congress of Basic ad Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] Zinc transporter SLC39A7/ZIP7 contributes to the tumorigenic potentials of human colorectal cancer cells2018
- Author(s)
  Ryusuke Horaguchi, Wakana Ohashi, Naoki Yamamine, Tetsuro Oda, and Yuichi Hattori
- Organizer
  18th World Congress of Basic ad Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 大腸がんにおけるWntアゴニストSKL2001の増殖制御機構の解析2018
- Author(s)
  大橋若奈、山峯直樹、井村穣二、服部裕一
- Organizer
  第９0回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 腸上皮恒常性維持における亜鉛トランスポーターZIP7の役割2018
- Author(s)
  大橋若奈、長谷耕二、深田俊幸
- Organizer
  第29回日本微量元素学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 腸上皮恒常性における亜鉛トランスポーターZIP7の役割2017
- Author(s)
  大橋若奈、長谷耕二、深田俊幸
- Organizer
  第12回トランスポーター研究会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] Role of the zinc transporter SLC39A7/ZIP7 in intestinal homeostatic self-renewal2017
- Author(s)
  Wakana Ohashi, Koji Hase, and Toshiyuki Fukada.
- Organizer
  International Society for the ISZB meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 亜鉛トランスポーター ZIP7 による腸管上皮恒常性維持機構2017
- Author(s)
  大橋若奈、長谷耕二、深田俊幸、服部裕一
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 亜鉛トランスポーターZIP7の大腸がんにおける機能解析2017
- Author(s)
  山峯直樹、大橋若奈、織田哲郎、洞口龍介、服部裕一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 大腸がんにおける亜鉛トランスポーター ZIP7 の役割2017
- Author(s)
  山峯直樹、大橋若奈、織田哲郎、洞口龍介、服部裕一
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K09373
[Presentation] 亜鉛トランスポーターによる小胞体ストレスと腸管上皮恒常性の制御機構2016
- Author(s)
  Wakana Ohashi, Koji Hase, Toshiyuki Fukada
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19319
[Presentation] 腸管上皮の自己複製機構における亜鉛トランスポーターの役割2016
- Author(s)
  大橋若奈、長谷耕二、深田俊幸
- Organizer
  第93回日本生理学会大会　シンポジウム14
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K19319
[Presentation] 腸管恒常性における亜鉛トランスポーターの役割2016
- Author(s)
  大橋若奈
- Organizer
  第13回　亜鉛栄養治療研究会
- Place of Presentation
  大阪新丸ビル
- Year and Date
  2016-08-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K19319

1. Hattori Yuichi (50156361)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. 井村穣二 (80316554)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 冨田賢吾 (20758213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 鈴木登紀子 (10415531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 早川芳弘 (10541956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIMURA Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. KIMURA Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 森寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 深田俊幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 美島健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 入江太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長谷耕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大津浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 轟木堅一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 田中智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 松田直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHASHI WAKANA 大橋 若奈

Research Projects

Research Products

Co-Researchers

亜鉛トランスポーターを介した代謝制御機構の解明に基づく大腸がん治療戦略の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prophylactic and therapeutic strategy based on the molecular pathology of septic disseminated intravascular coagulation (DIC)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of Zinc transporter detected in tumor lesions as a target for cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the role of Zinc transporter in intestinal stem cell maintenance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on GRK2 as a potential drug discovery target for the sepsis syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Zinc transporter in maintacnce of stemness of intestinal epithelial stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 悪性腫瘍における亜鉛動態と悪性化2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Regulatory role of GRK2 in the TLR signaling-mediated iNOS induction pathway in microglial cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maintenance of intestinal epithelial homeostasis by zinc transporters2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emerging role of zinc homeostasis by zinc transporter ZIP7 in intestinal homeostatic self-renewal2017

Author(s)

Journal Title

DOI

Data Source

OHASHI WAKANA 大橋若奈