Tajima Ken 田島健

Researcher Number	50384102
Other IDs
Affiliation (Current)	2023: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 順天堂大学, 医学部, 准教授 2019 – 2021: 順天堂大学, 医学部, 講師 2016 – 2018: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Respiratory organ internal medicine Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator エピジェネティクス / シングルセル解析 / 細胞老化 / 小細胞肺がん / 腫瘍内不均一性 / 薬剤耐性 / 胸部悪性腫瘍 / 阻害剤 / ユビキチン‐プロテオソーム経路 / 細胞周期 … More / ユビキチン‐プロテオソーム系 / SKP2 / 癌 / ヒストンメチル化酵素 / 中皮腫 / ヒストン脱メチル化酵素 / 中皮腫久 / LSD1 / ヒストン脱メチル化 / ヒストンメチル化 / ヒストン修飾 / エピジェンティクス / 肺がん … More Except Principal Investigator 新規治療標的 / 遺伝子解析 / スクリーニング解析 / チロシンキナーゼ / 遺伝子異常 / ゲノム構造多型 / スプライシング異常 / Keap1-Nrf2経路 / 酸化ストレス応答経路 / 非小細胞肺癌 / 糖鎖分子 / 薬剤耐性 / 肺癌 / 慢性閉塞性肺疾患 (COPD) / マイクロアレイ解析 / 喫煙 / 肺気腫 / 加熱式タバコ / DNA傷害 / 慢性閉塞性肺疾患(COPD) / ヒト小気道上皮細胞 / アポトーシス / グリセロール / プロピレングリコール / 新型タバコ / エピジェネティクス / シングルセル解析 / 腫瘍内不均一性 / 中皮腫 / 胸腺癌 / スクリーニング / 分子標的 / 分子標的治療薬 / 小細胞肺癌 Less

薬剤耐性クローンに着目した腫瘍内不均一性と薬剤耐性原理の解明Principal Investigator
- Principal Investigator
  
  田島健
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
肺癌における酸化ストレス応答系の新規破綻機序の解明と標的治療の探索
- Principal Investigator
  
  光石陽一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
エピジェネティクスの再構成の追跡による老化細胞の分類構築と新規治療法開発への挑戦Principal Investigator
- Principal Investigator
  
  田島健
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Juntendo University
中皮腫における細胞系譜構築による新規治療法の探究と臨床応用
- Principal Investigator
  
  高橋和久
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み
- Principal Investigator
  
  高橋史行
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
ユビキチン化を標的とした細胞死と細胞老化誘導による小細胞肺がん新規治療法の探索Principal Investigator
- Principal Investigator
  
  田島健
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
慢性タバコ煙曝露システムを用いた加熱式タバコエアロゾルによる肺傷害の解析
- Principal Investigator
  
  佐藤匡
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
analysis of novel transcript variant of tyrosine kinase gene in thymic carcinoma
- Principal Investigator
  
  Takahashi Kazuhisa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
analysis of novel transcript variant of tyrosine kinase gene in small cell lung cancer using the NanoString nCounter
- Principal Investigator
  
  Takahashi Fumiyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Inactivation of tumor suppressor by histone methylation in lung cancerPrincipal Investigator
- Principal Investigator
  
  Tajima Ken
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib2021
- Author(s)
  Nurwidya Fariz et al.
- Journal Title
  
  Thoracic Cancer
  
  Volume: in press Issue: 10 Pages: 1536-1548
- DOI
  10.1111/1759-7714.13937
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07092, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-21K08187
[Journal Article] Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation2020
- Author(s)
  Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K
- Journal Title
  
  Thorac Cancer
  
  Volume: 11 Issue: 1 Pages: 140-149
- DOI
  10.1111/1759-7714.13255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K09669
[Journal Article] LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer2017
- Author(s)
  Jotatsu, T., Yagishita, S., Tajima, K., Takahashi, F., Mogushi, K., Hidayat, M., Wirawan, A., Ko, R., Kanemaru, R., Shimada, N., Mitani, K., Saito, T., Takamochi, K., Suzuki, K., Kohsaka, S., Kojima, S., Mukae, H., Yatera, K., and Takahashi, K.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: ９ Pages: 86-94
- DOI
  10.1016/j.bbrep.2016.11.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09586, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-16K15625
[Presentation] Activation of IGF1R receptor confers acquired resistance to osimertinib in EGFR-mutant NSCLC with T790M mutation.2021
- Author(s)
  Daisuke Hayakawa, Fumiyuki Takahashi, Ken Tajima, Yoichiro Mitsuishi, Ikuko Takeda Nakamura, Wira Winardi, Yukina Shirai, Yosuke Miyashita, Tomoko Yamada, Keita Miura, Masahiro Torasawa, Hironari Matsuda, Tetsuhiko Asao, Takehito Shukuya, Kazuhisa Takahashi.
- Organizer
  第80回日本癌学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] Activation of IGF1R receptor confers acquired resistance to osimertinib in EGFR-mutant NSCLC with T790M mutation.2021
- Author(s)
  Daisuke Hayakawa, Fumiyuki Takahashi, Ken Tajima, Yoichiro Mitsuishi, Ikuko Takeda Nakamura, Wira Winardi, Yukina Shirai, Yosuke Miyashita, Tomoko Yamada, Keita Miura, Masahiro Torasawa, Hironari Matsuda, Tetsuhiko Asao, Takehito Shukuya, Kazuhisa Takahashi.
- Organizer
  第80回日本癌学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08187
[Presentation] インスリン様成長因子1受容体の活性化はT790M遺伝子変異陽性NSCLCにおけるオシメルチニブ耐性に寄与する2020
- Author(s)
  早川乃介、髙橋史行、光石陽一郎、田島健、中村育子、松本直久、金森幸一郎、高遼、朝尾哲彦、宿谷威仁、嶋村尚子、和泉研太、Wira Winardi、白井由紀奈、虎澤匡洋、三浦啓太、藤岡雅大、高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] 重複癌の既往と進行非小細胞肺癌に対する1次治療ペムブロリズマブの治療効果との関連の検討2020
- Author(s)
  三浦啓太、宿谷威仁、朝尾哲彦、阿部瞳、白井由紀奈、和泉研太、早川乃介、松本直久、金森幸一郎、嶋村尚子、光石陽一郎、田島健、柴山里奈、嶋田奈緒子、高橋史行、高遼、高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] 重複癌の既往と進行非小細胞肺癌に対する1次治療ペムブロリズマブの治療効果との関連の検討2020
- Author(s)
  三浦啓太、宿谷威仁、朝尾哲彦、阿部瞳、白井由紀奈、和泉研太、早川乃介、松本直久、金森幸一郎、嶋村尚子、光石陽一郎、田島健、柴山里奈、嶋田奈緒子、高橋史行、高遼、高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] 進行EGFR遺伝子変異/ALK融合遺伝子陽性NSCLCにおける、治療開始後5年以降の経過の検討2020
- Author(s)
  嶋村尚子，宿谷威仁，藤岡雅大，朝尾哲彦，白井由紀奈，三浦啓太, 和泉研太, 早川乃介，高遼，光石陽一郎，田島健，柴山里奈，嶋田奈緒子，髙橋史行，高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] 進行EGFR遺伝子変異/ALK融合遺伝子陽性NSCLCにおける、治療開始後5年以降の経過の検討2020
- Author(s)
  嶋村尚子，宿谷威仁，藤岡雅大，朝尾哲彦，白井由紀奈，三浦啓太, 和泉研太, 早川乃介，高遼，光石陽一郎，田島健，柴山里奈，嶋田奈緒子，髙橋史行，高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] インスリン様成長因子1受容体の活性化はT790M遺伝子変異陽性NSCLCにおけるオシメルチニブ耐性に寄与する2020
- Author(s)
  早川乃介、髙橋史行、光石陽一郎、田島健、中村育子、松本直久、金森幸一郎、高遼、朝尾哲彦、宿谷威仁、嶋村尚子、和泉研太、Wira Winardi、白井由紀奈、虎澤匡洋、三浦啓太、藤岡雅大、高橋和久
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] The novel therapeutic strategy targeting the mesenchymal phenotype by suppression of LSD1 in mesothelioma2019
- Author(s)
  Wirawan Aditya, 田島健, Hidayat Moulid, 松本直久, 早川乃介, 金森幸一郎, 和泉研太, 嶋村尚子, 朝尾哲彦, 嶋田奈緒子, 光石陽一郎, 高橋史行, 高橋和久
- Organizer
  日本癌学会総
- Data Source
  KAKENHI-PROJECT-16K09586
[Presentation] Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis.2018
- Author(s)
  Kono K, Kato M, Nakamura T, Yamada T, Tajima M, Ihara H, Tajima K, Shiota S, Takahashi F, Sasaki S, Seyama K, Takahashi K.
- Organizer
  American Thoracic Society 2018 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] In search of new therapy targeting histone methylation in cancer (International Symposium)2018
- Author(s)
  Ken Tajima, Yae Toshifumi, Fumiyuki Takahashi, Shyamala Maheswaran, Kazuhisa Takahashi
- Organizer
  日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-16K09586
[Presentation] The role of histone deacetylase in the maintenance of gefitinib-resistant lung cancer stem cells with epidermal growth factor receptor mutation.2018
- Author(s)
  Nurwidya F, Takahashi F, Hidayat M, Wirawan A, Baskoro H, Kato M, Tajima K, Shimada N, Andarini S.L, Yunus F, Takahashi K.
- Organizer
  American Thoracic Society 2018 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] The role of histone deacetylase in the maintenance of gefitinib-resistant lung cancer stem cells with epidermal growth factor receptor mutation.2018
- Author(s)
  Nurwidya F, Takahashi F, Hidayat M, Wirawan A, Baskoro H, Kato M, Tajima K, Shimada N, Andarini S.L, Yunus F, Takahashi K.
- Organizer
  American Thoracic Society 2018 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis.2018
- Author(s)
  Kono K, Kato M, Nakamura T, Yamada T, Tajima M, Ihara H, Tajima K, Shiota S, Takahashi F, Sasaki S, Seyama K, Takahashi K.
- Organizer
  American Thoracic Society 2018 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08185
[Presentation] The Epigenetic Roles of LSD1+8a in Small Cell Lung Cancer.2017
- Author(s)
  Wirawan A, Tajima K, Takahashi F, Hidayat M, Kanemaru R, Koinuma Y, Hayakawa D, Tajima M, Matsumoto N, Kanamori K, Takeda1 I, Kato M, Kobayashi I, Shimada N, Takahashi K.
- Organizer
  World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] Role of the ubiquitin ligase FBXW7/CDC4 in the maintenance of quiescent cancer stem cells resistant to gefitinib in EGFR mutation-positive non-small cell lung cancer (NSCLC).2017
- Author(s)
  Hidayat M, Takahashi F, Tajima K, Nurwidya F, Wirawan A, Kanemaru R, Koinuma Y, Ihara H, Tajima M, Matsumoto N, Kanamori K, Takeda I, Haraguchi M, Hayakawa D, Ko R, Kato M, Shibayama R, Koyama R, Takahashi M, Shimada N, Takahashi K.
- Organizer
  World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] Histone deacetylase inhibition alters stem cell phenotype in gefitinib-resistant lung cancer cells with epidermal growth factor receptor mutation.2017
- Author(s)
  Nurwidya F, Takahashi F, Hidayat M, Kobayashi I, Wirawan A, Kato M, Tajima K, Shimada N, Yunus, Takahashi K.
- Organizer
  World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09669
[Presentation] The Epigenetic Roles of LSD1+8a in Small Cell Lung Cancer2017
- Author(s)
  Aditya Wirawan、田島健、高橋史行、Moulid Hidayat、金丸良太、濃沼淑芳、早川乃介、田島学、松本直久、金森幸一郎、武田育子、加藤元康、小林功、嶋田奈緒子、高橋和久
- Organizer
  The International Association for the Study of Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09586
[Presentation] 小細胞肺がんにおけるヒストン脱メチル化酵素LSD1+8aの役割2016
- Author(s)
  Aditya Wirawan、田島健、丈達陽順、柳下薫寛、高遼、Moulid Hidayat、金丸良太、濃沼淑芳、井原宏彰、嶋田奈緒子、茂櫛薫、高橋史行、高橋和久
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16K09586

1. Takahashi Kazuhisa (80245711)

# of Collaborated Projects: 9 results

# of Collaborated Products: 20 results
2. Takahashi Fumiyuki (70327823)

# of Collaborated Projects: 8 results

# of Collaborated Products: 20 results
3. 光石陽一郎 (10647001)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 茂櫛薫 (60569292)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 柳下薫寛 (80781674)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 眞鍋理一郎 (30280837)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 鈴木健司 (10415523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 高遼 (60795178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐藤匡 (10596993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 瀬山邦明 (10226681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤平陽彦 (50721057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡崎康司 (80280733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 白石友一 (70516880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高阪真路

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tajima Ken 田島 健

Research Projects

Research Products

Co-Researchers

薬剤耐性クローンに着目した腫瘍内不均一性と薬剤耐性原理の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺癌における酸化ストレス応答系の新規破綻機序の解明と標的治療の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピジェネティクスの再構成の追跡による老化細胞の分類構築と新規治療法開発への挑戦Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

中皮腫における細胞系譜構築による新規治療法の探究と臨床応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ユビキチン化を標的とした細胞死と細胞老化誘導による小細胞肺がん新規治療法の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性タバコ煙曝露システムを用いた加熱式タバコエアロゾルによる肺傷害の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

analysis of novel transcript variant of tyrosine kinase gene in thymic carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

analysis of novel transcript variant of tyrosine kinase gene in small cell lung cancer using the NanoString nCounter

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inactivation of tumor suppressor by histone methylation in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Activation of IGF1R receptor confers acquired resistance to osimertinib in EGFR-mutant NSCLC with T790M mutation.2021

Tajima Ken 田島健