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Tajima Ken  田島 健

ORCIDConnect your ORCID iD *help
Researcher Number 50384102
Other IDs
Affiliation (Current) 2022: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2022: 順天堂大学, 医学部, 准教授
2019 – 2021: 順天堂大学, 医学部, 講師
2020: 順天堂大学, 医学部, 准教授
2016 – 2018: 順天堂大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords
Principal Investigator
小細胞肺がん / 肺がん / エピジェンティクス / ヒストン修飾 / ヒストンメチル化 / ヒストン脱メチル化 / LSD1 / 中皮腫久 / ヒストン脱メチル化酵素 / エピジェネティクス … More / 中皮腫 / ヒストンメチル化酵素 / 癌 / SKP2 / ユビキチン‐プロテオソーム系 / 細胞周期 / 細胞老化 / ユビキチン‐プロテオソーム経路 / 阻害剤 … More
Except Principal Investigator
遺伝子異常 / チロシンキナーゼ / スクリーニング解析 / 遺伝子解析 / 新規治療標的 / 小細胞肺癌 / 分子標的治療薬 / 分子標的 / スクリーニング / 胸腺癌 / 中皮腫 / 腫瘍内不均一性 / エピジェネティクス / シングルセル解析 / 肺癌 / 加熱式タバコ / 肺気腫 / アポトーシス / 慢性閉塞性肺疾患(COPD) / 喫煙 / マイクロアレイ解析 / 慢性閉塞性肺疾患 (COPD) Less
  • Research Projects

    (7 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (16 People)
  •  中皮腫における細胞系譜構築による新規治療法の探究と臨床応用

    • Principal Investigator
      高橋 和久
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Juntendo University
  •  肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み

    • Principal Investigator
      高橋 史行
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Juntendo University
  •  ユビキチン化を標的とした細胞死と細胞老化誘導による小細胞肺がん新規治療法の探索Principal Investigator

    • Principal Investigator
      田島 健
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Juntendo University
  •  慢性タバコ煙曝露システムを用いた加熱式タバコエアロゾルによる肺傷害の解析

    • Principal Investigator
      佐藤 匡
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Juntendo University
  •  胸腺癌における新規治療標的遺伝子異常の探索

    • Principal Investigator
      高橋 和久
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Juntendo University
  •  analysis of novel transcript variant of tyrosine kinase gene in small cell lung cancer using the NanoString nCounter

    • Principal Investigator
      Takahashi Fumiyuki
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Juntendo University
  •  Inactivation of tumor suppressor by histone methylation in lung cancerPrincipal Investigator

    • Principal Investigator
      Tajima Ken
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Juntendo University

All 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Activation of insulin‐like growth factor‐1 receptor confers acquired resistance to osimertinib in non‐small cell lung cancer with EGFR T790M mutation2020

    • Author(s)
      Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K
    • Journal Title

      Thoracic Cancer

      Volume: 11 Pages: 140-149

    • DOI

      10.1111/1759-7714.13255

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K09669
  • [Journal Article] LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer.2017

    • Author(s)
      Jotatsu, T., Yagishita, S., Tajima, K., Takahashi, F., Mogushi, K., Hidayat, M., Wirawan, A., Ko, R., Kanemaru, R., Shimada, N., Mitani, K., Saito, T., Takamochi, K., Suzuki, K., Kohsaka, S., Kojima, S., Mukae, H., Yatera, K., and Takahashi, K.
    • Journal Title

      Biochem Biophys Rep.

      Volume: 9 Pages: 86-94

    • DOI

      10.1016/j.bbrep.2016.11.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09586, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-16K15625
  • [Presentation] インスリン様成長因子1受容体の活性化はT790M遺伝子変異陽性NSCLCにおけるオシメルチニブ耐性に寄与する2020

    • Author(s)
      早川乃介、髙橋史行、光石陽一郎、田島健、中村育子、松本直久、金森幸一郎、高遼、朝尾哲彦、宿谷威仁、嶋村尚子、和泉研太、Wira Winardi、白井由紀奈、虎澤匡洋、三浦啓太、藤岡雅大、高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08185
  • [Presentation] 重複癌の既往と進行非小細胞肺癌に対する1次治療ペムブロリズマブの治療効果との関連の検討2020

    • Author(s)
      三浦啓太、宿谷威仁、朝尾哲彦、阿部瞳、白井由紀奈、和泉研太、早川乃介、松本直久、金森幸一郎、嶋村尚子、光石陽一郎、田島健、柴山里奈、嶋田奈緒子、高橋史行、高遼、高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08185
  • [Presentation] 重複癌の既往と進行非小細胞肺癌に対する1次治療ペムブロリズマブの治療効果との関連の検討2020

    • Author(s)
      三浦啓太、宿谷威仁、朝尾哲彦、阿部瞳、白井由紀奈、和泉研太、早川乃介、松本直久、金森幸一郎、嶋村尚子、光石陽一郎、田島健、柴山里奈、嶋田奈緒子、高橋史行、高遼、高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] 進行EGFR遺伝子変異/ALK融合遺伝子陽性NSCLCにおける、治療開始後5年以降の経過の検討2020

    • Author(s)
      嶋村尚子,宿谷威仁,藤岡雅大,朝尾哲彦,白井由紀奈,三浦啓太, 和泉研太, 早川乃介,高遼,光石陽一郎,田島健,柴山里奈,嶋田奈緒子,髙橋史行,高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] 進行EGFR遺伝子変異/ALK融合遺伝子陽性NSCLCにおける、治療開始後5年以降の経過の検討2020

    • Author(s)
      嶋村尚子,宿谷威仁,藤岡雅大,朝尾哲彦,白井由紀奈,三浦啓太, 和泉研太, 早川乃介,高遼,光石陽一郎,田島健,柴山里奈,嶋田奈緒子,髙橋史行,高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08185
  • [Presentation] インスリン様成長因子1受容体の活性化はT790M遺伝子変異陽性NSCLCにおけるオシメルチニブ耐性に寄与する2020

    • Author(s)
      早川乃介、髙橋史行、光石陽一郎、田島健、中村育子、松本直久、金森幸一郎、高遼、朝尾哲彦、宿谷威仁、嶋村尚子、和泉研太、Wira Winardi、白井由紀奈、虎澤匡洋、三浦啓太、藤岡雅大、高橋和久
    • Organizer
      第61回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] The novel therapeutic strategy targeting the mesenchymal phenotype by suppression of LSD1 in mesothelioma2019

    • Author(s)
      Wirawan Aditya, 田島 健, Hidayat Moulid, 松本 直久, 早川 乃介, 金森 幸一郎, 和泉 研太, 嶋村 尚子, 朝尾 哲彦, 嶋田 奈緒子, 光石 陽一郎, 高橋 史行, 高橋 和久
    • Organizer
      日本癌学会総
    • Data Source
      KAKENHI-PROJECT-16K09586
  • [Presentation] Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis.2018

    • Author(s)
      Kono K, Kato M, Nakamura T, Yamada T, Tajima M, Ihara H, Tajima K, Shiota S, Takahashi F, Sasaki S, Seyama K, Takahashi K.
    • Organizer
      American Thoracic Society 2018 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] In search of new therapy targeting histone methylation in cancer (International Symposium)2018

    • Author(s)
      Ken Tajima, Yae Toshifumi, Fumiyuki Takahashi, Shyamala Maheswaran, Kazuhisa Takahashi
    • Organizer
      日本呼吸器学会総会
    • Data Source
      KAKENHI-PROJECT-16K09586
  • [Presentation] The role of histone deacetylase in the maintenance of gefitinib-resistant lung cancer stem cells with epidermal growth factor receptor mutation.2018

    • Author(s)
      Nurwidya F, Takahashi F, Hidayat M, Wirawan A, Baskoro H, Kato M, Tajima K, Shimada N, Andarini S.L, Yunus F, Takahashi K.
    • Organizer
      American Thoracic Society 2018 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08185
  • [Presentation] The role of histone deacetylase in the maintenance of gefitinib-resistant lung cancer stem cells with epidermal growth factor receptor mutation.2018

    • Author(s)
      Nurwidya F, Takahashi F, Hidayat M, Wirawan A, Baskoro H, Kato M, Tajima K, Shimada N, Andarini S.L, Yunus F, Takahashi K.
    • Organizer
      American Thoracic Society 2018 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis.2018

    • Author(s)
      Kono K, Kato M, Nakamura T, Yamada T, Tajima M, Ihara H, Tajima K, Shiota S, Takahashi F, Sasaki S, Seyama K, Takahashi K.
    • Organizer
      American Thoracic Society 2018 International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08185
  • [Presentation] The Epigenetic Roles of LSD1+8a in Small Cell Lung Cancer.2017

    • Author(s)
      Wirawan A, Tajima K, Takahashi F, Hidayat M, Kanemaru R, Koinuma Y, Hayakawa D, Tajima M, Matsumoto N, Kanamori K, Takeda1 I, Kato M, Kobayashi I, Shimada N, Takahashi K.
    • Organizer
      World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] Role of the ubiquitin ligase FBXW7/CDC4 in the maintenance of quiescent cancer stem cells resistant to gefitinib in EGFR mutation-positive non-small cell lung cancer (NSCLC).2017

    • Author(s)
      Hidayat M, Takahashi F, Tajima K, Nurwidya F, Wirawan A, Kanemaru R, Koinuma Y, Ihara H, Tajima M, Matsumoto N, Kanamori K, Takeda I, Haraguchi M, Hayakawa D, Ko R, Kato M, Shibayama R, Koyama R, Takahashi M, Shimada N, Takahashi K.
    • Organizer
      World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] Histone deacetylase inhibition alters stem cell phenotype in gefitinib-resistant lung cancer cells with epidermal growth factor receptor mutation.2017

    • Author(s)
      Nurwidya F, Takahashi F, Hidayat M, Kobayashi I, Wirawan A, Kato M, Tajima K, Shimada N, Yunus, Takahashi K.
    • Organizer
      World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09669
  • [Presentation] The Epigenetic Roles of LSD1+8a in Small Cell Lung Cancer2017

    • Author(s)
      Aditya Wirawan、田島健、高橋史行、Moulid Hidayat、金丸良太、濃沼淑芳、早川乃介、田島学、松本直久、金森幸一郎、武田育子、加藤元康、小林功、嶋田奈緒子、高橋和久
    • Organizer
      The International Association for the Study of Lung Cancer
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09586
  • [Presentation] 小細胞肺がんにおけるヒストン脱メチル化酵素LSD1+8aの役割2016

    • Author(s)
      Aditya Wirawan、田島健、丈達陽順、柳下薫寛、高遼、Moulid Hidayat、金丸良太、濃沼淑芳、井原宏彰、嶋田奈緒子、茂櫛薫、高橋史行、高橋和久
    • Organizer
      第57回日本肺癌学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-16K09586
  • 1.  Takahashi Fumiyuki (70327823)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 2.  高橋 和久 (80245711)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 3.  茂櫛 薫 (60569292)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  眞鍋 理一郎 (30280837)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  柳下 薫寛 (80781674)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  鈴木 健司 (10415523)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  光石 陽一郎 (10647001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  高 遼 (60795178)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  藤平 陽彦 (50721057)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  佐藤 匡 (10596993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  瀬山 邦明 (10226681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  高阪 真路
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  上野 敏秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  末原 義之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  林 大久生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  小島 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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