Oonishi Hiroe 大西弘恵

… Alternative Names

Hireo Ohnishi 大西弘恵

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Researcher Number	50397634
Other IDs	https://orcid.org/0000-0003-3437-680X
Affiliation (Current)	2023: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都大学, 医学研究科, 特定助教 2017 – 2022: 京都大学, 医学研究科, 研究員 2016 – 2017: 京都大学, 医学研究科, 特定助教 2016: 京都大学, 医学(系)研究科(研究院), 助教 2015: 京都大学, 医学(系)研究科(研究院), 特定研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator ゲノム編集 / ヒトiPS細胞 / 蝸牛 / オルガノイド / 分化誘導 / 組換えマウス / 内耳蝸牛 / 三次元構造 / 極性 / Carbonic anhydrase 13 … More / 難聴モデル / トランスクリプトーム解析 / 内耳感覚上皮細胞 / 内耳オルガノイド / iPS細胞 / 前庭 / 内耳 / 共培養 / シナプス形成 / 神経細胞 / 色素性乾皮症 / 内耳感覚上皮組織培養 / 聴神経 / 神経分化誘導 / 疾患特異的iPS細胞 … More Except Principal Investigator 内耳 / 再生 / 有毛細胞 / 移植 / 気道上皮 / 難聴 / 感音難聴 / 蝸牛 / iPS細胞 / 免疫不全ラット / ヒトiPS細胞 / タンパク質 / 網羅的発現解析 / マクロファージ / 線維化 / 声帯 / 分化転換 / 内耳発生 / オルガノイド / ロボット手術 / iPS細胞移植 / 光刺激人工内耳 / 細胞移植 / 蝸牛神経 / 人工内耳 / 遺伝子 / 鼻腔粘膜 / 瘢痕化 / バリア破壊 / 新型コロナウイルス / CRISPR/CAS9 / ノックアウトスクリーニング / シュードウイルス / SARS-CoV-2 Spikeタンパク質 / ヒトiPS細胞由来気道上皮移植ラット / CRISPR/Cas9システム / COVID-19 / イメージング質量分析 / 発生 / トランスクリプトーム解析 / 遺伝子導入 / 光遺伝学 / エピジェネティクス / 気道線維化病変 / 極性 / 瘢痕 / 平衡障害 / 宇宙環境 / 前庭 / 微小重力 / 鳥類 / 蝸牛上皮 / 網羅的遺伝子解析 / 遺伝子発現 / 単一細胞 / 網羅的遺伝子発現解析 / トランスレーショナルリサーチ / 再生医学 / チャネルロドプシン / 蝸牛有毛細胞 / 聴力再生 / 間葉系幹細胞（MSC） / 聴神経（ラセン神経節細胞） / iPS細胞由来神経前駆細胞 / ヒト多能性幹細胞（iPS細胞） / ラセン神経節細胞 / 蝸牛神経（聴神経）（ / チャンネルロドプシン / iPS / 聴神経 / ヒト多能性幹細胞（iPS） / 遺伝学 / 細胞生物学 / 耳科学 / MYPT / 機能解析 / 新規変異 / リポジトリ / TRIOBP / 内耳機能 / 聴覚 / 遺伝性難聴 / EPHA2 / POLD1 / MYO6 / OTOA / CLDN14 / DIAPH1 / 前庭再生 / 前庭動眼反射 / hNSC / ｈNSC / 前庭障害 / ネトリン１ / 創薬 / インスリン様細胞増殖因子 / IGF-1 / 保護 / シナプス / インスリン様細胞増殖因子１ / 人工材料 / 軟骨細胞 / 分化誘導 / 筋細胞 / 気道上皮細胞 Less

マクロファージ動態制御による声帯線維化予防技術開発
- Principal Investigator
  
  岸本曜
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
Generation of the transplantation model of human iPS cell-derived airway epithelial sheet into nasal cavity
- Principal Investigator
  
  北田有史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
Elucidation of Inner Ear Development Mechanisms using multi-omics
- Principal Investigator
  
  山本典生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kobe City Medical Center General Hospital(First Clinical Division, Second Clinical Division, Third
  Kyoto University
光刺激人工内耳が加速させる細胞移植と分化転換からの蝸牛神経再生による新規難聴治療
- Principal Investigator
  
  西村幸司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
  Teikyo University
ヒトiPS細胞由来気道上皮細胞移植における生着効率向上因子の探索
- Principal Investigator
  
  桑田文彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
光刺激人工内耳技術とiPS細胞移植蝸牛神経再生の融合による新規難聴治療法の開発
- Principal Investigator
  
  伊藤壽一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
ヒト多能性幹細胞（iPS細胞）由来内耳オルガノイドの内耳移植による内耳再生研究
- Principal Investigator
  
  藤野清大
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Research Institute, Shiga Medical Center
内耳蝸牛三次元構造形成メカニズムの解明と蝸牛型オルガノイド作製への応用Principal Investigator
- Principal Investigator
  
  大西弘恵
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
Elucidation of the cochlear development and inner ear pathology with imaging mass-spectrometry for the treatment of sensorineural hearing loss
- Principal Investigator
  
  山本典生
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
CRISPR/Cas系による新型コロナウイルス感染と気道上皮バリア破壊機構の解明
- Principal Investigator
  
  大森孝一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Development of a new treatment method for hearing loss by fusing cochlear implant technology and cochlear nerve regeneration
- Principal Investigator
  
  ITO JUICHI
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Research Institute, Shiga Medical Center
Mechanisms for the initial process of hair cell regeneration in avian inner ears
- Principal Investigator
  
  中川隆之
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
宇宙環境における内耳前庭の発生維持とバイオメカニクス
- Principal Investigator
  
  田浦晶子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Aino University
マクロファージ極性制御による上気道線維化病変に対する新規治療技術開発
- Principal Investigator
  
  岸本曜
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
Elucidation of the develpmental mechanism of the cochlear sensory epithelia based on the single cell analysis
- Principal Investigator
  
  Yamamoto Norio
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
蝸牛・前庭感覚上皮発生機序の解析とヒトiPS細胞を用いた難聴モデル作製への応用Principal Investigator
- Principal Investigator
  
  大西弘恵
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kyoto University
Roles of IGF-1-Netrin axis in the cochlea
- Principal Investigator
  
  Nakagawa Takayuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
「平衡障害に対する新規治療法の開発」- iPS細胞による前庭再生医療 -
- Principal Investigator
  
  田浦晶子
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Aino University
  Department of Clinical Research, National Hospital Organization Kyoto Medical Center
The comprehesive analysis of human hereditary deafness
- Principal Investigator
  
  Kitajiri Shin-ichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shinshu University
Elucidation of pathogenic mechanisms of sensorineural hearing loss and establishment of disease model using XP-A patient-derived iPS cellsPrincipal Investigator
- Principal Investigator
  
  Hireo Ohnishi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
Development of regenerative medicine for head and neck tissues using murine and human iPS cells
- Principal Investigator
  
  Omori Koichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
  Fukushima Medical University

All 2021 2019 2017 2016

All Journal Article Presentation Book

[Book] 「iPS細胞の安全・高品質な作製技術、第6章, 第4節ヒトiPS細胞からの前庭神経節細胞作製の開発」2016
- Author(s)
  田浦晶子、大西弘恵
- Total Pages
  494
- Publisher
  株式会社技術情報協会
- Data Source
  KAKENHI-PROJECT-15K10748
[Journal Article] 前庭再生医療研究の将来展望2019
- Author(s)
  5.田浦晶子、大西弘恵、西村幸司、扇田秀章、中川隆之、山本典生、岡野高之、大森孝一、伊藤壽一
- Journal Title
  
  Equilibrium Research
  
  Volume: -
- NAID
  130007687327
- Data Source
  KAKENHI-PROJECT-17K11349
[Journal Article] 「前庭障害に対するiPS細胞移植の可能性」2016
- Author(s)
  田浦晶子　大西弘恵
- Journal Title
  
  月刊臨床神経科学　Clinical neurosciense
  
  Volume: 34 Pages: 1142-1144
- Data Source
  KAKENHI-PROJECT-15K10748
[Presentation] マウス内耳発生過程における転写因子Ebfファミリーの機能解析2021
- Author(s)
  鹿子島大貴, 山本亮介, 大西弘恵, 大森孝一, 山本典生
- Organizer
  第122回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19H03803
[Presentation] 単一細胞RNAシークエンシング公開データを利用した蝸牛の発生機構の探究2021
- Author(s)
  山本亮介, 大西弘恵, 大森孝一, 山本典生
- Organizer
  第122回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19H03803
[Presentation] ヒトiPS細胞からの内耳有毛細胞誘導法改良の試み2019
- Author(s)
  大西弘恵、デシスラヴァスケルレヴァ、奥山英晃、宮本達雄、松浦伸也、桐野浩輔、山本典生、伊藤壽一、大森孝一、齋藤潤、月田香代子、井上治久、中川隆之.
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K09318
[Presentation] ヒトiPS細胞からの内耳有毛細胞誘導法改良の試み2019
- Author(s)
  大西弘恵、デシスラヴァスケルレヴァ、奥山英晃、宮本達雄、松浦伸也、桐野浩輔、山本典生、伊藤壽一、大森孝一、齋藤潤、月田香代子、井上治久、中川隆之.
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K10748
[Presentation] ビトリゲル上でのヒトiPS細胞からの気道上皮細胞分化誘導2017
- Author(s)
  大西　弘恵、中村亮介、奥山英晃、竹澤俊明、後藤慎平、興梠陽平、小西聡史、山下勝、岸本曜、楯谷一郎、山本典生、中川隆之、大森孝一
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-26293371
[Presentation] ヒトiPS細胞から内耳有毛細胞様細胞を誘導するための段階的分化誘導法の検討2016
- Author(s)
  大西　弘恵、Desislava Skerleva、北尻　真一郎、坂本　達則、山本　典生、伊藤　壽一、中川　隆之
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  京都
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K10748

1. Yamamoto Norio (70378644)

# of Collaborated Projects: 10 results

# of Collaborated Products: 3 results
2. 西村幸司 (20405765)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
3. Nakagawa Takayuki (50335270)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
4. ITO JUICHI (90176339)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
5. 田浦晶子 (70515345)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
6. 扇田秀章 (20761274)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
7. 岸本曜 (80700517)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
8. Kitajiri Shin-ichiro (00532970)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. 喜多知子 (20362519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 岡野高之 (60642931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 池川雅哉 (60381943)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. Omori Koichi (10233272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 宮本達雄 (40452627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 松本昌宏 (80773811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 十名洋介 (80898073)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 桑田文彦 (20774459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 今泉光雅 (30554422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉江進 (70705459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 石川正昭 (10813743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宇佐美真一 (10184996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西尾信哉 (70467166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 飯田慶 (00387961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 宮崎浩 (00263228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 中島則行 (80625468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 松永麻美 (00599524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 小野宗範 (30422942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 藤野清大 (50359832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 朝長啓造 (10301920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 水田匡信 (20777875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 竹澤俊明 (50301297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 河合良隆 (50862223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 北田有史 (50869584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YUBA shyunsuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. MATSUDA toshirou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Oonishi Hiroe 大西 弘恵

Hireo Ohnishi 大西 弘恵

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内耳蝸牛三次元構造形成メカニズムの解明と蝸牛型オルガノイド作製への応用Principal Investigator

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Oonishi Hiroe 大西弘恵

Hireo Ohnishi 大西弘恵

[Book] 「iPS細胞の安全・高品質な作製技術、第6章, 第4節ヒトiPS細胞からの前庭神経節細胞作製の開発」2016