Awad Shamma Shamma A.A.Awad

Connect your ORCID iD *help

… Alternative Names

Shamma Awad シャムマアワド

SHAMMA Awad シヤムマアワド

シャムマアワドシヤムマアワド

シヤムマアワドシヤムマアワド

AWAD Shamma シャムマアクド

Less

Researcher Number	50402839
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2021 – 2022: 大阪大学, 医学系研究科, 招へい教員 2015 – 2017: 金沢大学, がん進展制御研究所, 助教 2011 – 2012: 金沢大学, がん進展制御研究所, 助教 2009 – 2010: 金沢大学, がん研究所, 助教 2006 – 2007: 京都大学, 医学研究科, 助教 2006: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Carcinogenesis / Tumor biology / Basic Section 55020:Digestive surgery-related Except Principal Investigator Biological Sciences / Pathological medical chemistry / Tumor biology
Keywords	Principal Investigator ATM / Rb / DNMT1 / p16^Ink4 / クロマチンリモデリング / エピジェネティック / がん / 抗がん剤 / p16Ink4a / RB … More / KAT3B / HDAC5 / Proteasome / Reprogramming proteins / Reprogramming factors / Protein degradation / cellular reprogramming / DNA damage / Protein ubiquitination / Stem cell reprogramming / Cancer / 癌幹細胞 / 動物モデル / ヒト検体 / シングルセル解析 … More Except Principal Investigator Rb / がん遺伝子 / ras / セネセンス / DNA損傷 / 悪性化 / がん抑制遺伝子 / 癌抑制遺伝子 / 甲状腺髄様がん / oncogene / tumor suppressor / malignant conversion / senescence / がん / がん幹細胞 / N-ras / Medullary thyroid cancer / metastasis / 細胞老化 / Ras / クロマチンリモデリング / DNA損傷応答 / 前がん病変 / イソプレニル化 / がん悪性化 / ノックアウトマウス / 甲状腺髄様癌 / mdullary thyroiod carcinoma / DNA damage / がん代謝 / RB / 解糖系 / 脂質代謝 / PGAM / 代謝 / コレステロール / 糖代謝 / グルタミン Less

シングルセル解析を駆使した癌幹細胞の捕捉と新規治療法の開発Principal Investigator
- Principal Investigator
  
  Shamma A.A.Awad
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathwayPrincipal Investigator
- Principal Investigator
  
  Awad Shamma
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Regulation of metabolism by RB tumor suppressor gene
- Principal Investigator
  
  Takahashi Chiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
The role of Rb-Ras pathway in cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  SHAMMA Awad
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Kanazawa University
Analysis of cellular signals toward carcinogenesis and metastasis using genetically modified mice
- Principal Investigator
  
  TAKAHASHI Chiaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
複合変異マウスを用いたがん化・転移シグナルの研究
- Principal Investigator
  
  TAKAHASHI Chiaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Wild type N-ras as a tumor suppressor in human sporadic medullary thyroid cardnoma
- Principal Investigator
  
  TAKAHASHI Chiaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University

All 2017 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] The genetic and biochemical interactions of Rb and ras.(Seikagaku(in Japanese)Oct;81(10))2009
- Author(s)
  C. Takahashi, Y. Takegami, A. Shamma
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] The Genetic-Epigenetic Interplay in Cancer2015
- Author(s)
  Awad Shamma and Hayato Muranaka
- Journal Title
  
  J Cancer Biol Res
  
  Volume: 3 Pages: 1072-1084
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06834
[Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs interferes withepidermal growth factor receptor signaling.2011
- Author(s)
  S.Kitajima, T.Miki, Y.Takegam, Y.Kido, M.Noda, E.Hara, A.Shamma , C.Takahashi.
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 737-750
- NAID
  120002907445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500998
[Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling2011
- Author(s)
  S.Kitajima, T.Miki, Y.Takegam, Y.Kido, M.Noda, E.Hara, A.Shamma, C.Takahashi
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 737-750
- DOI
  10.1038/onc.2010.448
- NAID
  120002907445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500998
[Journal Article] The・β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis2010
- Author(s)
  T. Miki, A. Shamma, S. Kitajima, Y. Takegami, M. Noda, Y. Nakashima, K. Watanabe, C. Takahashi
- Journal Title
  
  Mol. Cancer Res.
- NAID
  120002224338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] The β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis.2010
- Author(s)
  T.Miki, A.Shamma, S.Kitajima, Y.Takegami, M.Noda, Y.Nakashima, K.Watanabe, C.Takahashi.
- Journal Title
  
  Mol.Cancer Res. (印刷中)
- NAID
  120002224338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] The bl-integrin-dependent function of BECK in physiologic and tumor anglogenesls.2010
- Author(s)
  T.Miki, A.Shamma, S.Kitajima, Y.Takegami, M.Noda, Y.Nakashima, K.Watanabe , C.Takahashi.
- Journal Title
  
  Mol.Cancer Res.
  
  Volume: 8 Pages: 665-676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500998
[Journal Article] Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-Ras Isoprenylation.2009
- Author(s)
  A. Shamma, Y. Takegami, T. Miki, S. Kitajima, M. Noda, T. Obara, T. Okamoto, C. Takahashi
- Journal Title
  
  Cancer Cell 15
  
  Pages: 255-269
- NAID
  120001546496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-Ras Isoprenylation.2009
- Author(s)
  A.Shamma, Y.Takegami, T.Miki, S.Kitajima, M.Noda, T.Obara, T.Okamoto, C.Takahashi.
- Journal Title
  
  Cancer Cell 15
  
  Pages: 255-269
- NAID
  120001546496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-Ras Isoprenylation2009
- Author(s)
  A. Shamma, Y. Takegami, T, Miki, S. Kitajima, M. Noda, T. Ohara, T. Okamoto and C. Takahashi
- Journal Title
  
  Cancer Cell 15
- NAID
  120001546496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] The genetic and biochemical interactions of Rb and ras.2009
- Author(s)
  C.Takahashi, Y.Takegami, A.Shamma.
- Journal Title
  
  Seikagaku (in Japanese) 81(10)
  
  Pages: 873-883
- NAID
  10026298655
- Data Source
  KAKENHI-PROJECT-20012027
[Journal Article] ATM mediates pRB function to control DNMT1 protein stability and DNA methylation
- Author(s)
  Shamma A., Suzuki M., Hayashi N., Kobayashi M., Sasaki N., Nishiuchi T., Doki Y., Okamoto T., Kohno S., Muranaka H, Kitajima S.,Yamamoto K., Takahashi C
- Journal Title
  
  Molecular and Cellular Biology
- NAID
  120005312327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] ATM and RB functions regulate stemness by targeting the core reprogramming proteins for proteasomal degradation2017
- Author(s)
  Awad Shamma
- Organizer
  76th Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06834
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression2015
- Author(s)
  Sasaki N, Kitajima S, Muranaka H, Shamma A, Kohno S, Takahashi C
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver・Canada・Fairmont Hotel
- Year and Date
  2015-01-16
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression.2014
- Author(s)
  Sasaki N, Muranaka H, Kitajima S, Kohno S, Shamma A and Takahashi C
- Organizer
  第37回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構.2014
- Author(s)
  佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析2014
- Author(s)
  村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 吉田晶代, 丹下正一朗, 鈴木健之, 林昭夫, 多田秀昭, Shamma A, 髙橋智聡
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市・パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26290037
[Presentation] Epigenetic function of retinoblastoma protein entails functional association of ATM and DNMT12012
- Author(s)
  Shamma Awad
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館、札幌市、日本
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] ATM regulates DNMT1 protein stability and coordinates its acetylation-driven ubiquitination during Rb loss-induced carcinogenesis Gordon Conference2012
- Author(s)
  Shamma A., Kido Y., Sasaki N., Takahashi C
- Place of Presentation
  California, USA
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] ATM regulates DNMT1 protein stability and coordinates its acetylation-driven ubiquitination during Rb loss-induced carcinogenesis2012
- Author(s)
  A.Shamma, Y.Kido, N.Sasaki, C.Takahashi
- Organizer
  Gordon Conference (DNA Damage, Mutation & Cancer)
- Place of Presentation
  Ventura Beach Marriott(アメリカ)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] Epigenetic function of retinoblastoma protein entails functional association of ATM and DNMT12012
- Author(s)
  Shamma A., Sasaki N., Takahashi C
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館、札幌市
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] DNMT1 Links DNA Damage Response and Cellular Senescence during Rb deficiency-induced Tumorigenesis2011
- Author(s)
  Shamma A., Takahashi C
- Organizer
  第70回日本癌学会学術総会(招待講演)
- Place of Presentation
  名古屋国際会議場、愛知県
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] DNMT1 Links DNA Damage Response and Cellular Senescence during Rb deficiency-induced Tumorigenesis2011
- Author(s)
  A.Shamma, C.Takahashi
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] ATM mediates the Rb loss-induced DNA damage response and senescence through chromatin remodeling and p16Ink4a regulation2010
- Author(s)
  Shamma A., Takahashi C
- Organizer
  第69回日本癌学会学術総会(招待講演)
- Place of Presentation
  大阪国際会議場、大阪)
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] ATM mediates the Rb loss-induced DNA damage response andsenescence through chromatin remodeling and pl61nk4aregulation.2010
- Author(s)
  A.Shamma , C.Takahashi.
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)((招待講演))
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] The Rb-Ras pathway in malignant progression.2010
- Author(s)
  C.Takahashi , A.Shamma.
- Organizer
  国際がん生物学シンポジウム
- Place of Presentation
  国立中山大学(台湾)
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PROJECT-22500998
[Presentation] The genetic interaction of Rb and ras unveiled by the study of compound knockout mice.2009
- Author(s)
  C. Takahashi, Y. Takegami, T. Miki, S. Kitajima, A. Shamma
- Organizer
  日本生化学会大会シンポジウム
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] The genetic interaction of Rb and ras in the multi-step carcinogenesis model2009
- Author(s)
  C. Takahashi, A. Shamma
- Organizer
  癌学会総会シンポジウム
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] The genetic interaction of Rb and ras unveiled by the study of compound knockout mice2009
- Author(s)
  C.Takahashi, Yujiro Takegami, Takao Miki, Shunsuke Kitajima, A.Shamma
- Organizer
  日本生化学会大会シンポジウム
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] The function and mechanism of pRb-N-Ras pathway in metastatic conversion of neuroendocrine thyroid tumor.2009
- Author(s)
  C.Takahashi, A.Shamma
- Organizer
  Korean Society for Biochemistry and Molecular Biology (KSBMB)シンポジウム
- Place of Presentation
  COEX (Seoul, Korea)
- Year and Date
  2009-05-13
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] Critical role of cellular senescence mediated by N-Ras isoprenylation in suppressing Rb-deficient C-cell carcinogenesis2009
- Author(s)
  A. Shamma, C. Takahashi
- Organizer
  日本癌学会総会口頭発表
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] The function and mechanism of pRb-N-Ras pathway in metastatic conversion of neuroendocrine thyroid tumor2009
- Author(s)
  C. Takahashi, A. Shamma
- Organizer
  Korean Society for Biochemistry and Molecular Biology (KSBMB)シンポジウム
- Place of Presentation
  COEX (Korea)
- Year and Date
  2009-05-13
- Data Source
  KAKENHI-PROJECT-20012027
[Presentation] Critical role of cellular senescence mediated by N-Ras isoprenylation in suppressing Rb-deficient C-cell carcinogenesis2009
- Author(s)
  A.Shamma, C.Takahashi
- Organizer
  日本癌学会総会口頭発表
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20012027

1. TAKAHASHI Chiaki (50283619)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. Hayashi Naoyuki (50253456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Kitajima Syunsuke (90566465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Kohno Susumu (30625463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. Sasaki Nobunari (40415170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 奥崎大介 (00346131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 安藤幸滋 (20608864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本浩文 (30322184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 横山雄起 (60615714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤心二 (90382423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 江口英利 (90542118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Awad Shamma Shamma A.A.Awad

Shamma Awad シャムマ アワド

SHAMMA Awad シヤムマ アワド

シャムマ アワド シヤムマ アワド

シヤムマ アワド シヤムマ アワド

AWAD Shamma シャムマ アクド

Research Projects

Research Products

Co-Researchers

シングルセル解析を駆使した癌幹細胞の捕捉と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of metabolism by RB tumor suppressor gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Rb-Ras pathway in cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cellular signals toward carcinogenesis and metastasis using genetically modified mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複合変異マウスを用いたがん化・転移シグナルの研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wild type N-ras as a tumor suppressor in human sporadic medullary thyroid cardnoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The genetic and biochemical interactions of Rb and ras.(Seikagaku(in Japanese)Oct;81(10))2009

Author(s)

Data Source

[Journal Article] The Genetic-Epigenetic Interplay in Cancer2015

Author(s)

Journal Title

Data Source

[Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs interferes withepidermal growth factor receptor signaling.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The・β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The bl-integrin-dependent function of BECK in physiologic and tumor anglogenesls.2010

Shamma Awad シャムマアワド

SHAMMA Awad シヤムマアワド

シャムマアワドシヤムマアワド

シヤムマアワドシヤムマアワド

AWAD Shamma シャムマアクド