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Yoshitomi Hiroyuki  吉富 啓之

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YOSHITOMI Hiroyuki  吉富 啓之

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Researcher Number 50402920
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 京都大学, 医学研究科, 准教授
2016 – 2018: 京都大学, ウイルス・再生医科学研究所, 准教授
2012: 京都大学, 医学(系)研究科(研究院), 准教授
2012: 京都大学, 医学研究科, 准教授
2011: 京都大学, 医学(系)研究科(研究院), 助教
2008 – 2009: Kyoto University, 医学研究科, 助教
2006 – 2007: 京都大学, 医学研究科, 医員
Review Section/Research Field
Principal Investigator
Orthopaedic surgery / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56020:Orthopedics-related
Except Principal Investigator
Basic Section 56020:Orthopedics-related / Basic Section 56040:Obstetrics and gynecology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Surgery related to the biological and sensory functions and related fields
Keywords
Principal Investigator
T細胞 / Tph細胞 / PD-1 / CXCL13 / 関節リウマチ / TH17 / 免疫学 / 症性サイトカイン / B細胞 / 炎症性サイトカイン … More / T細胞分化 / がん微小環境 / 子宮体がん / エピゲノム / 転写因子 / Sox4 / ヒト免疫学 / ゲノム編集 / 強直性脊椎炎 / 血清反応陰性関節炎 / CRISPR-Cas9 / 遺伝子編集 / HLA B27 / 血清反応陰性脊椎関節炎 / iPS細胞 / 骨・軟骨・靭帯 / 分泌マイクロRNA / バイオマーカー / 骨折治療 / マイクロRNA / ケモカイン / アレルギー・喘息 / IL-23 / 臨床 / アレルギー・ぜんそく … More
Except Principal Investigator
破骨細胞 / iPS細胞 / 婦人科がん / TLS / 腫瘍免疫 / 関節リウマチ / GWAS / エンハンサー / シングルセル解析 / 軟骨細胞 / 変形性関節症 / 細菌叢 / 3次リンパ様構造 / Tph細胞 / マクロファージ / B細胞性免疫 / 婦人科腫瘍学 / 卵巣癌 / 子宮体癌 / T細胞 / B細胞 / 婦人科癌 / IDH遺伝子 / 軟骨肉腫 / IDH1遺伝子 / 軟骨形成性腫瘍 / 疾患iPS細胞 / 進行性骨化性線維異形成症異 / 進行性骨化性繊維異形成症 / mTOR / 異所性骨化 / FOP / 進行性骨化性線維異形成症 / SNP / 炎症性疾患 / 骨粗鬆症 / 低酸素 / RIPアッセイ / 軟骨分化誘導 / 翻訳制御機構 / 分化段階特異的 / 翻訳制御 / 軟骨分化 / 骨組織 / 骨細胞 / 骨芽細胞 / 骨疾患 / 骨改変 / IPS細胞 / オルガノイド Less
  • Research Projects

    (15 results)
  • Research Products

    (91 results)
  • Co-Researchers

    (25 People)
  •  免疫細胞による新規筋骨格組織破壊修復機構の解明

    • Principal Investigator
      村田 浩一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Elucidation of tertiary lymphoid structures (TLS) in gynecological cancer and basic investigation of new treatment development

    • Principal Investigator
      濱西 潤三
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Kyoto University
  •  Pathophysiology of osteoarthritis focusing on transcriptional enhancers from GWAS and single cell RNAseq analysis

    • Principal Investigator
      西谷 江平
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Investigation of B-cell immunity against gynecological cancer and new strategies for diagnosis and treatment

    • Principal Investigator
      濱西 潤三
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Kyoto University
  •  Elucidation of Human Cancer Immunity Based on Analysis of CXCL13-Producing T Cells in the Cancer MicroenvironmentPrincipal Investigator

    • Principal Investigator
      Yoshitomi Hiroyuki
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kyoto University
  •  Investigation of temporospatial dynamics of Sox4 in the pathogenesis of RAPrincipal Investigator

    • Principal Investigator
      Yoshitomi Hiroyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Elucidation of mechanism underlying the chondrogenesis-specific translational regulation

    • Principal Investigator
      JIN YONGHUI
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kyoto University
  •  Elucidation of mechanism for the enhancement of osteoclast differentiation under hypoxia and development of new therapeutic approach for bone resorption in rheumatoid arthritis

    • Principal Investigator
      Murata Koichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Mechanism analysis of heterotopic ossification formation in Fibrodysplasia Ossificans Progressiva (FOP)

    • Principal Investigator
      Jin Yonghui
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Comprehensive understanding of spatio-temporal effects of mutant IDH1 during the development of cartilage forming tumors

    • Principal Investigator
      Toguchida Junya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto University
  •  Development of bone-organod and its application for the research in bone diseases

    • Principal Investigator
      TOGUCHIDA JUNYA
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kyoto University
  •  Pathogenesis elucidation of seronegative spondyloarthritis using patient-derived iPSCsPrincipal Investigator

    • Principal Investigator
      Yoshitomi Hiroyuki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kyoto University
  •  Analysis for the mechanism of the repair from injury of bone, cartilage and ligament using fluid microRNAsPrincipal Investigator

    • Principal Investigator
      YOSHITOMI Hiroyuki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kyoto University
  •  Analysis of Th17 axis in the pathogenesis of human rheumatoid arthritis.Principal Investigator

    • Principal Investigator
      YOSHITOMI Hiroyuki
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kyoto University
  •  関節リウマチにおけるIL-23/IL-17免疫経路の解析と治療への応用Principal Investigator

    • Principal Investigator
      吉富 啓之
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 医学のあゆみ277巻9号2021

    • Author(s)
      吉富 啓之
    • Total Pages
      196
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Book] 実験医学2022年1月号2021

    • Author(s)
      吉富 啓之
    • Total Pages
      135
    • Publisher
      羊土社
    • ISBN
      9784758125512
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Book] 【リウマチ性疾患の病態における適応免疫と治療への展望】関節リウマチ病態における適応免疫と治療への展望2020

    • Author(s)
      吉富 啓之, 上野 英樹
    • Total Pages
      7
    • Publisher
      リウマチ科
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Book] 「日本医事新報」別冊(【臨床医学の展望】整形外科学)2010

    • Author(s)
      吉富啓之、中村孝志
    • Total Pages
      7
    • Publisher
      日本医事新報
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Book] 臨床医学の展望2009(関節リウマチ, No4426)2009

    • Author(s)
      吉富啓之
    • Publisher
      日本医事新報
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Book] 「日本医事新報」特集臨床医学の展望20092009

    • Author(s)
      吉富啓之, 他
    • Total Pages
      136
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Peripheral helper T cells, mavericks of peripheral immune responses2023

    • Author(s)
      Yoshitomi Hiroyuki
    • Journal Title

      International Immunology

      Volume: 36 Issue: 1 Pages: 9-16

    • DOI

      10.1093/intimm/dxad041

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20610
  • [Journal Article] CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer2022

    • Author(s)
      Ukita Masayo、Hamanishi Junzo、Yoshitomi Hiroyuki、Yamanoi Koji、Takamatsu Shiro、Ueda Akihiko、Suzuki Haruka、Hosoe Yuko、Furutake Yoko、Taki Mana、Abiko Kaoru、Yamaguchi Ken、Nakai Hidekatsu、Baba Tsukasa、Matsumura Noriomi、Yoshizawa Akihiko、Ueno Hideki、Mandai Masaki
    • Journal Title

      JCI Insight

      Volume: 7 Issue: 12 Pages: 157215-157215

    • DOI

      10.1172/jci.insight.157215

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-22K09630, KAKENHI-PROJECT-20K20610, KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-20K21665, KAKENHI-PROJECT-20K22810
  • [Journal Article] CXCL13-producing PD-1hiCXCR5? helper T cells in chronic inflammation2020

    • Author(s)
      Yoshitomi Hiroyuki
    • Journal Title

      Immunological Medicine

      Volume: 43 Issue: 4 Pages: 156-160

    • DOI

      10.1080/25785826.2020.1781998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20610, KAKENHI-PROJECT-19H03780
  • [Journal Article] Recapitulating the human segmentation clock with pluripotent stem cells2020

    • Author(s)
      Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C
    • Journal Title

      Nature

      Volume: 580 Issue: 7801 Pages: 124-129

    • DOI

      10.1038/s41586-020-2144-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Journal Article] The limitations of mono‐ and combination antibiotic therapies on immature biofilms in a murine model of implant‐associated osteomyelitis2020

    • Author(s)
      Tomizawa Takuya、Nishitani Kohei、Ito Hiromu、Okae Yu、Morita Yugo、Doi Kohei、Saito Motoo、Ishie Shinichiro、Yoshida Shigeo、Murata Koichi、Yoshitomi Hiroyuki、Kuroda Yutaka、Matsuda Shuichi
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 39 Issue: 2 Pages: 449-457

    • DOI

      10.1002/jor.24956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09621, KAKENHI-PROJECT-18H02926
  • [Journal Article] Culture substrate‐associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells2020

    • Author(s)
      Yamashita Akihiro、Yoshitomi Hiroyuki、Kihara Shunsuke、Toguchida Junya、Tsumaki Noriyuki
    • Journal Title

      STEM CELLS Translational Medicine

      Volume: 10 Issue: 1 Pages: 115-127

    • DOI

      10.1002/sctm.20-0058

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02923, KAKENHI-PROJECT-18H02929, KAKENHI-PROJECT-18H02924
  • [Journal Article] Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR12020

    • Author(s)
      Maekawa Hirotsugu、Kawai Shunsuke、Nishio Megumi、Nagata Sanae、Jin Yonghui、Yoshitomi Hiroyuki、Matsuda Shuichi、Toguchida Junya
    • Journal Title

      Orphanet Journal of Rare Diseases

      Volume: 15 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s13023-020-01406-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02928, KAKENHI-PROJECT-18H02929
  • [Journal Article] Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases2020

    • Author(s)
      Yoshitomi Hiroyuki、Ueno Hideki
    • Journal Title

      Cellular & Molecular Immunology

      Volume: 18 Issue: 3 Pages: 523-527

    • DOI

      10.1038/s41423-020-00529-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20610, KAKENHI-PROJECT-19H03780
  • [Journal Article] A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.2020

    • Author(s)
      Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 20787-20787

    • DOI

      10.1038/s41598-020-77735-2

    • NAID

      120006940250

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09408, KAKENHI-PROJECT-18H02926, KAKENHI-PROJECT-18H02927, KAKENHI-PROJECT-19H03435
  • [Journal Article] Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis.2019

    • Author(s)
      Okahata A, Ito H, Furu M, Ishikawa M, Fujii T, Hashimoto M, Tanaka M, Morita Y, Azukizawa M, Tomizawa T, Doi K, Nishitani K, Murata K, Yoshitomi H, Mimori T, Matsuda S.
    • Journal Title

      J Clin Rheumatol

      Volume: - Issue: 7 Pages: 295-300

    • DOI

      10.1097/rhu.0000000000001116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Journal Article] Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes2019

    • Author(s)
      Yoshitomi Hiroyuki
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1395-1395

    • DOI

      10.3389/fimmu.2019.01395

    • NAID

      120006786922

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02926, KAKENHI-PROJECT-19H03780
  • [Journal Article] In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes2019

    • Author(s)
      Kawai Shunsuke、Yoshitomi Hiroyuki、Sunaga Junko、Alev Cantas、Nagata Sanae、Nishio Megumi、Hada Masataka、Koyama Yuko、Uemura Maya、Sekiguchi Kazuya、Maekawa Hirotsugu、Ikeya Makoto、Tamaki Sakura、Jin Yonghui、Harada Yuki、Fukiage Kenichi、Adachi Taiji、Matsuda Shuichi、Toguchida Junya
    • Journal Title

      Nature Biomedical Engineering

      Volume: 3 Issue: 7 Pages: 558-570

    • DOI

      10.1038/s41551-019-0410-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02928, KAKENHI-PROJECT-18H02929, KAKENHI-PROJECT-18K19614
  • [Journal Article] Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments.2018

    • Author(s)
      Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3762-3762

    • DOI

      10.1038/s41467-018-06187-0

    • NAID

      120006523829

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15663, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17H04059, KAKENHI-PROJECT-18H02926, KAKENHI-PROJECT-18H02929, KAKENHI-PROJECT-17K19725
  • [Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database2013

    • Author(s)
      Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
    • Journal Title

      PLoS One

      Volume: 8(3) Issue: 3 Pages: e59341-e59341

    • DOI

      10.1371/journal.pone.0059341

    • NAID

      120005244457

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390258, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23659719, KAKENHI-PROJECT-23791112, KAKENHI-PROJECT-23791113, KAKENHI-PROJECT-24659274
  • [Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.2012

    • Author(s)
      Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
    • Journal Title

      Arthritis Rheum

      Volume: 64 Issue: 4 Pages: 1024-1034

    • DOI

      10.1002/art.33452

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390051, KAKENHI-PROJECT-23659719
  • [Journal Article] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.2012

    • Author(s)
      Murata, K.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 5 Pages: 237-44

    • DOI

      10.1371/journal.pone.0037163

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390096, KAKENHI-PROJECT-23659719, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111003
  • [Journal Article] PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes.2010

    • Author(s)
      Nishitani K, Yoshitomi H, et al.
    • Journal Title

      J Cell Biochem 109(2)

      Pages: 425-433

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase c-JUN pathway via EP4 in human articular chondrocytes.2010

    • Author(s)
      Nishitani K, Ito H, Hiramitsu T, Tsutsumi R, Tanida S, Kitaori T, Yoshitomi H Kobayashi M, Nakamura T.
    • Journal Title

      J Cell Biochem. 109(2)

      Pages: 425-433

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus.2009

    • Author(s)
      Kitaori T, Ito H, Yoshitomi H, et al.
    • Journal Title

      Mod Rheumatol. 19(4)

      Pages: 431-436

    • NAID

      10025113669

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6(+) mononuclear cells and enhances the production of IL-6.2009

    • Author(s)
      Tanida S, Yoshitomi H Nishitani K, Ishikawa M, Kitaori T, Ito H, Nakamura T.
    • Journal Title

      Cytokine 47(2)

      Pages: 112-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6.2009

    • Author(s)
      Tanida S, Yoshitomi H, et al.
    • Journal Title

      Cytokine 42(2)

      Pages: 112-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Mimori T. Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009

    • Author(s)
      Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T
    • Journal Title

      Arthritis Rheum. 60(8)

      Pages: 2294-2303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009

    • Author(s)
      Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, et al.
    • Journal Title

      Arthritis Rheum. 60(8)

      Pages: 2294-2303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.2009

    • Author(s)
      Kitaori T, Ito H, Schwarz EM, Tsutsumi R, Yoshitomi H, Oishi S, Nakano M, Fujii N, Nagasawa T, Nakamura T
    • Journal Title

      Arthritis Rheum 60(3)

      Pages: 813-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.2008

    • Author(s)
      Wakasa-Morimoto C, Toyosaki-Maeda T, Matsutani T, Yoshida R, Nakamura-Kikuoka S, Maeda-Tanimura M, Yoshitomi H, Hirota K, Hashimoto M, Masaki H, Fujii Y, Sakata T, Tsuruta Y, Suzuki R, Sakaguchi N, Sakaguchi S
    • Journal Title

      Int Immunol 20(10)

      Pages: 1331-1342

    • NAID

      10024357361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Journal Article] Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.2007

    • Author(s)
      Hirota K, Yoshitomi H, Hashimoto M, et. al.
    • Journal Title

      Journal of Experimental Medicine 204(12)

      Pages: 2803-2812

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18890093
  • [Journal Article] T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.2007

    • Author(s)
      Hirota K, Hashimoto M, Yoshitomi H, et. al.
    • Journal Title

      Journal of Experimental Medicine 204(1)

      Pages: 41-47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18890093
  • [Presentation] 関節リウマチにおけるヒトT細胞の分化と機能2021

    • Author(s)
      吉富啓之
    • Organizer
      第8回JCRベーシックリサーチカンファレンス
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 変異型IDH1は通常酸素下において癌遺伝子誘導性細胞老化を引き起こす2020

    • Author(s)
      鎌倉 武史、金永輝、玉置さくら、渡辺真、岡本健、吉富啓之、戸口田淳也
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] ヒト自己免疫疾患におけるTph細胞2020

    • Author(s)
      吉富啓之
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 進行性骨化性線維異形成症における異所性骨化形成機構の解析2020

    • Author(s)
      金永輝、吉富啓之、西尾恵、鎌倉武史、玉置さくら、孫麗萍、戸口田淳也
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] 変異型IDH1は通常酸素下において癌遺伝子誘導性細胞老化を引き起こす2020

    • Author(s)
      鎌倉武史、金永輝、玉置さくら、渡辺真、岡本健、吉富啓之、戸口田淳
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] 変異型IDH1は通常酸素下において癌遺伝子誘導性細胞老化を引き起こす2020

    • Author(s)
      鎌倉武史、金永輝、玉置さくら、渡辺真、岡本健、吉富啓之、戸口田淳也
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] 変異型IDH1は通常酸素下において癌遺伝子誘導性細胞老化を引き起こす2020

    • Author(s)
      鎌倉武史、金永輝、玉置さくら、渡辺真、岡本健、吉富啓之、戸口田淳也
    • Organizer
      第79回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] Application of pluripotent stem cells for in vitro sarcomagenesis2020

    • Author(s)
      Tamaki S, Nagata S, Jin Y, Yoshitomi H, Toguchida J
    • Organizer
      第79回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] Application of pluripotent stem cells for in vitro sarcomagenesis2020

    • Author(s)
      Tamaki S, Nagata S, Jin Y, Yoshitomi H, Toguchida J
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] Prophylactic treatment of rapamycin ameliorates naturally developing and episode-induced heterotopic ossification in mice expressing human mutant ACVR12020

    • Author(s)
      Maekawa H, Kawai S, Nshio M, Nagata S, Jin Y, Yoshitomi H, Matsuda S, Toguchida J
    • Organizer
      ASBMR 2020 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] 関節リウマチ炎症環境によるT細胞の病態機能制御2019

    • Author(s)
      吉富啓之、小林志緒、宮川文、岡畠章憲、土井浩平、西谷江平、村田浩一、伊藤宣、鶴山 竜昭、羽賀博典、松田秀一、 戸口田淳也
    • Organizer
      第5回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 軟骨形成性腫瘍における変異型IDH1及びp16の機能的意義について2019

    • Author(s)
      鎌倉 武史、永田 早苗、湯川 愛友、西尾 恵、金 永輝、吉富 啓之、戸口田 淳也
    • Organizer
      第78回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] 進行性骨化性線維異形成症に対するmTOR阻害剤の有効性の検討2019

    • Author(s)
      前川裕継、吉富啓之、川井俊介、金永輝、松田秀一、戸口田淳也
    • Organizer
      第37回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K19614
  • [Presentation] 異所性リンパ濾胞におけるヘルパーT細胞の病態機構2019

    • Author(s)
      吉富啓之
    • Organizer
      第6回T-cell seminar
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 進行性骨化性線維異形成症における異所性骨化形成機構の解析2019

    • Author(s)
      金永輝、吉富啓之、,戸口田淳也
    • Organizer
      第18回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] 進行性骨化性線維異形成症に対するmTOR阻害剤の有効性の検討2019

    • Author(s)
      前川裕継、吉富啓之、川井俊介、金永輝、西尾恵、永田早苗、松田秀一、戸口田淳也
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] 進行性骨化性線維異形成症に対するmTOR阻害剤の有効性の検討2019

    • Author(s)
      前川裕継、吉富啓之、川井俊介、金永輝、西尾恵、永田早苗、松田秀一、戸口田淳也
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-18K19614
  • [Presentation] 進行性骨化性線維異形成症における異所性骨化形成機構の解析2019

    • Author(s)
      金永輝、吉富啓之、戸口田淳也
    • Organizer
      第18回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-18K19614
  • [Presentation] 進行性骨化性線維異形成症における異所性骨化形成機構の解析2019

    • Author(s)
      金永輝、吉富啓之、西尾恵、鎌倉武史、玉置さくら、戸口田淳也
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K19614
  • [Presentation] 進行性骨化性線維異形成症に対するmTOR阻害剤の有効性の検討2019

    • Author(s)
      前川裕継、吉富啓之、川井俊介、金永輝、松田秀一、戸口田淳也
    • Organizer
      第37回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments2019

    • Author(s)
      吉富啓之
    • Organizer
      令和元年日本リウマチ財団学術女性受賞者記念講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 進行性骨化性線維異形成症における異所性骨化形成機構の解析2019

    • Author(s)
      金永輝、吉富啓之、西尾恵、鎌倉武史、玉置さくら、戸口田淳也
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02928
  • [Presentation] Tph細胞の病態機構制御に関わる転写因子群2019

    • Author(s)
      吉富啓之、小林志緒、宮川(林野)文、岡畠章憲、土井浩平、西谷江平、村田浩一、伊藤 宣、鶴山竜昭、羽賀博典、松田秀一、戸口田淳也
    • Organizer
      第63回日本リウマチ学会
    • Data Source
      KAKENHI-PROJECT-19H03780
  • [Presentation] 多能性幹細胞を用いたin vitro肉腫発生機序解明の試み2019

    • Author(s)
      玉置 さくら、永田 早苗、湯川 愛友、西尾 恵、金 永輝、吉富 啓之、戸口田 淳也
    • Organizer
      第78回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] Functional significance of mutant IDH1 and p16INK4A in cartilage-forming tumor2019

    • Author(s)
      Kamakura T、Jin Y, Tamaki S, Watanabe M, Okamoto T, Yoshitomi H, Toguchida J
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] 滑膜肉腫におけるFZD10を介したシグナル伝達経路とその生物学的意義の解析2018

    • Author(s)
      宗圓 充、玉置 さくら、湯川 愛友、鎌倉 武史、金 永輝、岡本 健、吉富 啓之、戸口田 淳也
    • Organizer
      第51回日本整形外科学会 骨・軟部腫瘍学術集会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] In vitroにおける長期的なSS18-SSX融合タンパクの機能評価方法の開発2018

    • Author(s)
      玉置 さくら、永田 早苗、吉富 啓之、湯川 愛友、宗圓 充、鎌倉 武史、金 永輝、戸口田 淳也
    • Organizer
      第51回日本整形外科学会 骨・軟部腫瘍学術集会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] 整形疾患の創薬基礎研究の現在 ~リウマチ研究からiPS細胞研究まで~2018

    • Author(s)
      吉富啓之
    • Organizer
      第31回上本町整形外科フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] 疾患特異的iPS細胞を活用した病態解析から創薬2018

    • Author(s)
      戸口田淳也、日野恭介、池谷真、関口和也、金永輝、岡本健、吉富啓之、松田秀一
    • Organizer
      第36回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19725
  • [Presentation] 軟骨形成性腫瘍における変異型IDHの機能的意義について2018

    • Author(s)
      鎌倉 武史、金 永輝、玉置 さくら、渡辺 真、岡本 健、吉富 啓之、戸口田 淳也
    • Organizer
      第51回日本整形外科学会 骨・軟部腫瘍学術集会
    • Data Source
      KAKENHI-PROJECT-18H02929
  • [Presentation] Visualizing bone-like nodule formation using human induced pluripotent stem cells2018

    • Author(s)
      Kawai S、Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M,Hada M, Fukiage K, Adachi T, Matsuda S, Toguchida T
    • Organizer
      Orthopaedic Research Society 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19725
  • [Presentation] 創薬応用を目指したヒトiPS細胞によるin vtiro骨形成過程再現系の構築2018

    • Author(s)
      川井俊介、吉富啓之、Cantas Aleve、永田早苗、西尾恵、須長純子、羽田匡孝、金永輝、玉置さくら、池谷真、吹上謙一、安達泰治、松田秀一、戸口田淳也
    • Organizer
      第17回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17K19725
  • [Presentation] 1からわかるiPS細胞 -難病の薬を開発する-2017

    • Author(s)
      吉富啓之
    • Organizer
      NHK文化センター京都教室特別講座
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] 関節リウマチ滑膜炎の炎症病態 -臨床サンプルの解析から-2017

    • Author(s)
      吉富啓之
    • Organizer
      第 16 回関西膠原病フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] 炎症環境下 ヒトCD4陽性 T 細胞の転写制御解析2017

    • Author(s)
      吉富啓之、小林志緒、土井浩平、岡畠章憲、伊藤宣、 松田秀一、 戸口田淳也
    • Organizer
      JCRベーシックリサーチカンファレンス
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] Transcriptional regulation of PD-1+CD4+ T cells under inflammatory conditions2017

    • Author(s)
      吉富啓之、土井浩平、伊藤宣、松田秀一、戸口田淳也
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] 整形外科関連疾患の創薬基礎研究の現在 ~リウマチ研究からiPS細胞研究まで~2017

    • Author(s)
      吉富啓之
    • Organizer
      第25回西整医病診連携の会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15663
  • [Presentation] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.2013

    • Author(s)
      Murata K, Kitaori T,Ito H, Yoshitomi H,Furu M, Ishikawa M, Shibuya H, MatsudaS.
    • Organizer
      59th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      San Antonio, USA. NIRA finalist
    • Year and Date
      2013-01-26
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] SDF-1は軟骨細胞のアクチン細胞骨格を制御し、肥大化を促進する2012

    • Author(s)
      村田 浩一、伊藤 宣、北折 俊之、吉富啓之 村田 浩一、伊藤 宣、北折 俊之、吉富啓之
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋.
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] Comprehensive microRNA analysis identifies miR-24, miR-26a, and miR-125a-5p as plasma biomarkers for rheumatoid arthritis.2012

    • Author(s)
      Murata K,Yoshitomi H, Ishikawa M, Shibuya H,Ito H,Matsuda S.
    • Organizer
      2012 ACR/ARHP Annual Meeting.
    • Place of Presentation
      Washington DC. USA.
    • Year and Date
      2012-11-11
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] A crucial role for lectin-like oxidized LDL receptor-1 signal on cartilage destruction in inflammatory arthritis.2012

    • Author(s)
      Ishikawa M,Ito H, Akiyoshi M, Yoshitomi H,Murata K, Tanida S, Shibuya H, Kume N, Sawamura T, Nakamura T
    • Organizer
      58th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-02-06
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] MatsudaS. Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy2012

    • Author(s)
      Murata K, Kitaori T,Ito H, Yoshitomi H,Furu M, Ishikawa M, Shibuya H
    • Organizer
      GCOE リトリート2012
    • Place of Presentation
      淡路
    • Year and Date
      2012-10-05
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] Analysis of synovial tissue with inflammation of rheumatoid arthritis as a tertiary lymphoid organ2012

    • Author(s)
      吉富啓之、小林志緒
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] A crucial role for lectin-like oxidized LDL receptor-1 signal on synovial inflammation in RA.2012

    • Author(s)
      Ishikawa M,Ito H, Akiyoshi M, Murata K, Tanida S, Shibuya H, KasaharaY, Yoshitomi H Nakamura T.
    • Organizer
      The Annual European Congress of Rheumatology EULAR2012
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2012-06-06
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] A crucial role for lectin-like oxidized low-density lipoprotein receptor-1 signal in rheumatoid arthritis.2012

    • Author(s)
      Ishikawa M,Ito H, Yoshitomi H,Akiyoshi M, Murata K, Furu M, Matuda S.
    • Organizer
      15th Asia Pacific League of Associations for Rheumatology (APLAR)
    • Place of Presentation
      JORDAN
    • Year and Date
      2012-09-11
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] 血漿・関節液マイクロRNAは関節リウマチの疾患バイオマーカーとなりうるか2011

    • Author(s)
      村田浩一、吉富啓之、伊藤宣、中村孝志
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] 関節疾患と分泌microRNA2011

    • Author(s)
      吉富啓之、村田浩一、伊藤宣、中村孝志
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] 関節リウマチ滑膜にはIL-27産生性CD14陽性細胞が浸潤し炎症や遊走を制御する2011

    • Author(s)
      吉富啓之、伊藤宣、中村孝志
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] 施行した人工関節の種類によってその後の死亡率に差があるのかー人工関節置換術後生存率調査-2011

    • Author(s)
      伊藤宣、吉富啓之、中村伸一郎、中村孝志
    • Organizer
      第55回日本リウマチ学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] 強直性脊椎炎に対する レミケードの使用経2011

    • Author(s)
      吉富 啓之 伊藤 宣 中村孝志
    • Organizer
      京整会RA懇話会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-03
    • Data Source
      KAKENHI-PROJECT-23659719
  • [Presentation] CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-62010

    • Author(s)
      谷田司明、吉富啓之, 他
    • Organizer
      第56回ORS
    • Place of Presentation
      New Orleans U.S.A
    • Year and Date
      2010-03-06
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6.2010

    • Author(s)
      Shimei Tanida, Hiroyuki Yoshitomi, Kohei Nishitani, Masahiro Ishikawa, Toshiyuki Kitaori, Hiromu Ito, Takashi Nakamura
    • Organizer
      56th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      New Orleans
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] RA診療の基本と薬物療法の初歩の初歩2009

    • Author(s)
      吉富啓之
    • Organizer
      京都大学整形外科第5回京整会若手研修会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-06
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] 関節リウマチの病態におけるリンパ球の役割2009

    • Author(s)
      吉富啓之
    • Organizer
      京都大学整形外科19回リウマチ学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-05
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] 関節リウマチの病態におけるリンパ球の役割2009

    • Author(s)
      吉富啓之
    • Organizer
      第19回日本リウマチ学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-05
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] Involvement of CCL20/CCR6 axis in the pathogenesis of human and murine autoimmune arthritis.2009

    • Author(s)
      吉富啓之
    • Organizer
      Global COE Retreat 2009
    • Place of Presentation
      淡路島
    • Year and Date
      2009-11-07
    • Data Source
      KAKENHI-PROJECT-20791032
  • [Presentation] 関節リウマチ様関節炎自然発症モデルにおける真菌β-GlucanおよびDectin-1受容体の関与2007

    • Author(s)
      吉富啓之 坂口教子 坂口志文 中村孝志
    • Organizer
      日本軟骨代謝学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-03-04
    • Data Source
      KAKENHI-PROJECT-18890093
  • [Presentation] 関節疾患と分泌microRNA

    • Author(s)
      吉富啓之
    • Organizer
      第26回 日本整形外科学会基礎学術集会(招待講演)
    • Place of Presentation
      ベイシア文化ホール(前橋市)
    • Data Source
      KAKENHI-PROJECT-23659719
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