CHAMOTO Kenji 茶本健司

Researcher Number	50447041
Other IDs
Affiliation *help	2018 : 京都大学, 医学研究科, 特定准教授 2016 – 2018 : 京都大学, 医学研究科, 特定講師 2015 : 京都大学, 医学(系)研究科(研究院), 講師 2012 : 北海道大学, 遺伝子病制御研究所, 助教 2007 – 2008 : Hokkaido University, 遺伝子病制御研究所, 助教 2008 : Hokkaido University, 遺伝子病研究所, 助教
Review Section/Research Field	Principal Investigator Immunology / Tumor biology and related fields / Tumor therapeutics Except Principal Investigator Radiation science / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 免疫学 / PD-1 / 癌 / 細胞性免疫 / 体液性免疫 / 腫瘍免疫 / 腫瘍免疫学 / 細胞生物学 / 遺伝子 / Treg / サイトカイン / 生体分子 / B 細胞 … More Except Principal Investigator … More

Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancerOngoing
- Principal Investigator
  
  濱西潤三
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
生体内がん排除システムに基づいたPD-1抗体治療感受性決定遺伝子の同定と機能解析Principal InvestigatorOngoing
- Principal Investigator
  
  茶本健司
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyoto University
PD-1シグナル阻害によるTregの免疫抑制解除と抗腫瘍免疫活性化の機序解明Principal InvestigatorOngoing
- Principal Investigator
  
  茶本健司
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
抗PD-1抗体による抗腫瘍免疫応答の解明Principal Investigator
- Principal Investigator
  
  茶本健司
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Research for Real-time Tracking Medical Science
- Principal Investigator
  
  SHIRATO Hiroki
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
The development of type-1 tumor immunotherapy based on removing immunosupression from tumor-bearerPrincipal Investigator
- Principal Investigator
  
  CHAMOTO Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University

All 2015 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] がん分子標的治療2015
- Author(s)
  茶本健司
- Total Pages
  5
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15H06331
[Book] 免疫バランス制御の新しいパラダイム : Th1主導免疫によるがんエスケープ機構の克服2008
- Author(s)
  茶本健司、脇田大功、西村孝司
- Total Pages
  7
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19790351
[Book] 細胞工学2008
- Author(s)
  茶本健司、脇田大功、西村孝司
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] 3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.2010
- Author(s)
  Chamoto K, et al.
- Journal Title
  
  Cancer Science (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065
[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : Its potentiation by combination with Th1 cell therapy2010
- Author(s)
  Takeshima T, Chamoto K, et al.
- Journal Title
  
  Cancer Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065
[Journal Article] IFN-g-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model. Carcinogenesis2009
- Author(s)
  Wakita D, Chamoto K, et al.
- Journal Title
  
  Carcinogenesis 30
  
  Pages : 1408-1408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065
[Journal Article] Sialyl lewisx antigen-expressing human CD4+T and CD8+T cells as initial immune responders in memory phenotype subsets2009
- Author(s)
  Zhang Y and Chamoto K, et.al.
- Journal Title
  
  J Leukoc Biol. 84
  
  Pages : 730-735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Potential differentiation of tumor bearing mouse CD11b+ Gr-1+ immature myeloid cells into both supressor macrophage and immunostimmulatory dendritic cells2009
- Author(s)
  Narita Y and Chamoto K, et.al.
- Journal Title
  
  Biomedical Research 30
  
  Pages : 7-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinom a cells. 932009
- Author(s)
  Chamoto K, Takeshima T, Wakita D, Ohkuri T, Ashino S, Omatsu T, Shirato H, Kitamura H, Togashi Y, Nishimura T.
- Journal Title
  
  Cancer Sci. 100(5)
  
  Pages : 934-939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065
[Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells.2009
- Author(s)
  Chamoto K,Takeshima T, Wakita D, Ohkuri T, Ashino S, Omatsu T, Shirato, H, Kitamura H, Nishimura T.
- Journal Title
  
  Cancer Science 100(5)
  
  Pages : 394-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Indispensable role of IL-6-dependent spontaneous proliferation in inducing colitogenic IL-17-producing CD8^+T cells.2008
- Author(s)
  Tajima M., Chamoto K., et. al.
- Journal Title
  
  Journal of Experimental Medicine (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer.2008
- Author(s)
  Yokouchi H., Chamoto K., et. al.
- Journal Title
  
  Cancer Science 99
  
  Pages : 361-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung.2008
- Author(s)
  Ashino S., Chamoto K, et. al.
- Journal Title
  
  International Immunology 20
  
  Pages : 259-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] 免疫バランス制御の新しいパラダイム:Th1 主導免疫によるがんエスケープ機構の克服2008
- Author(s)
  茶本健司、脇田大功、西村孝司
- Journal Title
  
  先端医学社分子細胞治療 7(3)
  
  Pages : 171-180
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma.2007
- Author(s)
  Yokouchi H, Chamoto K(第一著者と同等に貢献), et. al.
- Journal Title
  
  Clinical & Experimental Metastasis 24
  
  Pages : 533-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Blocking of IL-6 signaling pathway prevents CD4_+T cell-mediated colitis in a T(h)17-independent manner. Int Immunol.2007
- Author(s)
  Noguchi D., Chamoto K, et. al.
- Journal Title
  
  International Immunology 19
  
  Pages : 1431-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs.2007
- Author(s)
  Zhang Y., Chamoto K, et. al.
- Journal Title
  
  International Immunology 19
  
  Pages : 151-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma.2007
- Author(s)
  Yokouchi H, Chamoto K (第一著者と同等に貢献), Wakita D, Yamazaki K, Shirato H, Takeshima T, Dosaka-Akita H, Nishimura M, Yue Z, Kitamura H, Nishimura T.
- Journal Title
  
  Clinical & Experimental Metastasis. 24
  
  Pages : 533-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Identification of novel helper epitopes of MAGE-A4 tumour antigen : useful tool for the propagation of Thl cells
- Author(s)
  Ohkuri T and Chamoto K, et.al.
- Journal Title
  
  Br J Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio-and immuno-resistant lung carcinoma cells
- Author(s)
  Kenji Chamoto, Takashi Nismura, et.al.
- Journal Title
  
  Cancer Science (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] uPA overexpressed in cancer stem cell promote the immunosuppressive tumor escape via TGF-β-Treg axis2009
- Author(s)
  Chamoto K, et al.
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21249065
[Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction.2009
- Author(s)
  Chamoto K, et al.
- Organizer
  American Association for Cancer Research 100th Annual Meeting.
- Place of Presentation
  USA, Colorado Convention Cente, Denver
- Year and Date
  2009-04-21
- Data Source
  KAKENHI-PROJECT-21249065
[Presentation] Urokinase-type plasminogen activator overexpressed in cancer stem cell promote the immunosuppressive tumor escape via TGF-β-Treg axis2009
- Author(s)
  茶本健司, et al.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21249065
[Presentation] CD133^+癌幹細胞に高発現するuPAは活性型TGF-β産生促進を介してTregを誘導する2009
- Author(s)
  茶本健司, et al.
- Organizer
  第13回がん免疫学会総会
- Place of Presentation
  福岡、北九州国際会議場
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-21249065
[Presentation] 担癌生体内のTregを介した免疫抑制機構の解明メチルコラントレン誘発性上皮癌と肉腫のTGF-b産生能力の違いとその意義2008
- Author(s)
  茶本健司
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  埼玉県大宮ソニックシティ
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] TGF-beta high-producing ability of mouse carcinomas determines their refractoriness against Treg-depletion therapy.2008
- Author(s)
  Takashi Nishimura., Kenji Chamoto.
- Organizer
  12th International Conference on Lymphocyte Activati on and Immune Regulation.
- Place of Presentation
  Fairmont Newport Beach Hotel
- Year and Date
  2008-02-08
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] Treg誘導を介した癌幹細胞の免疫抑制機構の解明2008
- Author(s)
  茶本健司
- Organizer
  第67回日本癌学学会術総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] 癌幹細胞によるTregを介した新規免疫抑制機構の解明2008
- Author(s)
  茶本健司
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都、国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction癌幹細胞によるTregを介した新規免疫抑制機構の解明2008
- Author(s)
  茶本健司、脇田大功、打浪雄介、大栗敬幸、西村孝司
- Organizer
  第38 回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] TGF-beta high-producing ability of mouse carcinomas determines their refractoriness against Treg-depletion therapy.2008
- Author(s)
  Takashi Nishimura, Daiko Wakita, Masaki Tajima and Kenji Chamoto.
- Organizer
  12th International Conference on Lymphocyte Activation and Immune Regulation.
- Place of Presentation
  California
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] 担癌生体内のTregを介した免疫抑制機構の解明メチルコラントレン誘発性上皮癌と肉腫のTGF-ss産生能力の違いとその意義2008
- Author(s)
  茶本健司、脇田大功、成田義規、富樫裕二、北村秀光、西村孝司
- Organizer
  第12 回基盤的癌免疫研究会総会抄録
- Place of Presentation
  埼玉県さいたま市大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction. Treg誘導を介した癌幹細胞の免疫抑制機構の解明2008
- Author(s)
  茶本健司、脇田大功、成田義規、大栗敬幸、打浪雄介、富樫裕二、北村秀光、西村孝司
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発2007
- Author(s)
  茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
- Organizer
  第11 回基盤的癌免疫研究会総会抄録
- Place of Presentation
  東京大学鉄門記念講堂
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] 原発性上皮癌と肉腫におけるTregを介した免疫抑制機構の解明2007
- Author(s)
  茶本健司、脇田大功、成田義規、張悦、北村秀光、西村孝司
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発2007
- Author(s)
  茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
- Organizer
  第11回基盤的癌免疫研究会総会
- Place of Presentation
  東京大学鉄門記念講堂
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発2007
- Author(s)
  茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発2007
- Author(s)
  茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
- Organizer
  第66 回日本癌学会総会・学術会記録
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19790351
[Presentation] Differential role of Treg-mediated immunosupression between carcinoma- and sarcoma-bearing mice2007
- Author(s)
  Kenji Chamoto, Daiko Wakita, Yoshinori Narita, Zhang Yue, Hidemitsu Kitamura, Takashi Nishimura
- Organizer
  第37回日本免疫学会総会・学術集会記録
- Place of Presentation
  東京グランドプリンスホテル新高輪
- Data Source
  KAKENHI-PROJECT-19790351

1. SHIRATO Hiroki (20187537)

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2. HONMA Sato (20142713)

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3. TAMAKI Nagara (30171888)

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33. MANABE Noriko (70463742)

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34. ABO Daisuke (30399844)

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35. KATO Fumi (80399865)

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36. KHIN KHIN Tha (20451445)

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37. NAM Jin-min (60414132)

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38. SABE Hisataka (40187282)

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39. INUBUSHI Masayuki (70399830)

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40. SHINAGAWA Naofumi (20431372)

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41. KENNETH Sutherland (30451446)

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42. 濱西潤三 (80378736)

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43. 万代昌紀 (80283597)

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44. 安彦郁 (20508246)

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45. 村上隆介 (40782363)

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46. Brown John (90583188)

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CHAMOTO Kenji 茶本 健司

Research Projects

Research Products

Co-Researchers

Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancerOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体内がん排除システムに基づいたPD-1抗体治療感受性決定遺伝子の同定と機能解析Principal InvestigatorOngoing

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PD-1シグナル阻害によるTregの免疫抑制解除と抗腫瘍免疫活性化の機序解明Principal InvestigatorOngoing

Principal Investigator

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抗PD-1抗体による抗腫瘍免疫応答の解明Principal Investigator

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Research for Real-time Tracking Medical Science

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The development of type-1 tumor immunotherapy based on removing immunosupression from tumor-bearerPrincipal Investigator

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[Book] がん分子標的治療2015

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[Book] 免疫バランス制御の新しいパラダイム : Th1主導免疫によるがんエスケープ機構の克服2008

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[Book] 細胞工学2008

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[Journal Article] 3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.2010

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[Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : Its potentiation by combination with Th1 cell therapy2010

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[Journal Article] IFN-g-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model. Carcinogenesis2009

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[Journal Article] Sialyl lewisx antigen-expressing human CD4+T and CD8+T cells as initial immune responders in memory phenotype subsets2009

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[Journal Article] Potential differentiation of tumor bearing mouse CD11b+ Gr-1+ immature myeloid cells into both supressor macrophage and immunostimmulatory dendritic cells2009

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[Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinom a cells. 932009

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[Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells.2009

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CHAMOTO Kenji 茶本健司