Yamanoi Koji 山ノ井康二

Researcher Number	70868075
Other IDs
Affiliation (Current)	2026: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Basic Section 58060:Clinical nursing-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 卵巣癌 / オレイン酸 / ステアリン酸 / MRI画像 / 子宮頸がん / 長鎖脂肪酸 / パルミチン酸 / 食事療法 / 小胞体ストレス / 脂肪酸 … More / 翻訳後修飾 / パルミトイル化 / 不飽和脂肪酸 / 高脂肪食 / アシル化 / DNA障害 / 飽和脂肪酸 … More Except Principal Investigator 卵巣癌 / ゲノム / 代謝 / 腸内細菌 / 炎症食 / QOL / 化学療法 / 食事 / 膵臓がん / 卵巣がん / がん早期診断 / 脂肪酸代謝リプログラミング / 子宮体癌 / 免疫ゲノミクス / 婦人科がん / 婦人科腫瘍学 / 巣癌 / 多様性 / 腫瘍免疫 / 婦人科腫瘍 / 高齢者 / リンパ浮腫 / ランダム化比較試験 / アドヒアランス / 圧迫療法 / 高齢がん患者 / 下肢リンパ浮腫 / ピリミジン合成阻害 / 5FU / 葉酸受容体 / 核酸合成阻害 / ピリミジン塩基 / 尿素窒素 / 核酸代謝 / dNTP / 核酸 / 脂質代謝 / 子宮内膜症 / 明細胞癌 / Hippoシグナル / YAP / フェロトーシス / 卵巣明細胞癌 Less

Development of an innovative early cancer diagnosis system targeting fatty acid metabolic reprogramming.
- Principal Investigator
  
  加藤侑希
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
  Basic Section 90140:Medical technology assessment-related
  Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
- Research Institution
  Nihon University
臨床所見やゲノム情報など多様なデータを駆使した子宮頸癌悪性度予測モデル構築の試みPrincipal Investigator
- Principal Investigator
  
  山ノ井康二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Elucidation of tertiary lymphoid structures (TLS) in gynecological cancer and basic investigation of new treatment development
- Principal Investigator
  
  Mandai Masaki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
婦人科がん患者のQOLや治療成績に関わる食事と腸内細菌叢・代謝物の探索的研究
- Principal Investigator
  
  山口建
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Elucidation of the mechanism by which stearic acid suppresses ovarian cancer cell proliferation.Principal Investigator
- Principal Investigator
  
  Yamanoi Koji
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
The development of a program to promote adherence to compression therapy in elderly patients with lower limb lymphedema.
- Principal Investigator
  
  井沢知子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Kobe City College of Nursing
  Kyoto University
Role of Ferotosis based on Lipid Metabolism in Endometriosis and Ovarian Cancer
- Principal Investigator
  
  Yamaguchi Ken
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Investigation of the mechanism of nucleic acid metabolism to establish a a new therapeutic strategy.
- Principal Investigator
  
  Kitamura Sachiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Elucidatinon of the mechanism by wihch fatty acids alter the malignant features of ovarian cancer int terms of palmitoylation.Principal Investigator
- Principal Investigator
  
  Yamanoi Koji
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in uterine carcinosarcoma2025
- Author(s)
  Sakurai Azusa、Yamaguchi Ken、Ishida Kentaro、Horikawa Naoki、Kawai Eri、Kotani Yasushi、Yoshida Takaaki、Kishimoto Naoya、Tatsumi Keiji、Okudate Minami、Iemura Yoko、Taga Yukiko、Aki Megumi、Ando Yukiko、Yanai Akihiro、Yamanoi Koji、Taki Mana、Murakami Ryusuke、Hamanishi Junzo、Mandai Masaki
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 30 Issue: 3 Pages: 570-583
- DOI
  10.1007/s10147-024-02687-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21473, KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-24K12601
[Journal Article] Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer2025
- Author(s)
  Suzuki Haruka、Hamada Kohei、Hamanishi Junzo、Ueda Akihiko、Murakami Ryusuke、Taki Mana、Mizuno Rin、Watanabe Koichi、Sato Hanako、Hosoe Yuko、Ito Hiroaki、Yamanoi Koji、Yoshitomi Hiroyuki、Kakiuchi Nobuyuki、Yamaguchi Ken、Matsumura Noriomi、Ogawa Seishi、Ueno Hideki、Mandai Masaki
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 74 Issue: 3 Pages: 84-84
- DOI
  10.1007/s00262-024-03929-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00009, KAKENHI-PROJECT-23K21473, KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-23K27741, KAKENHI-PROJECT-24K12601
[Journal Article] A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response2024
- Author(s)
  Ogura Jumpei、Yamanoi Koji、Ishida Kentaro、Nakamura Eijiro、Ito Shinji、Aoyama Naoki、Nakanishi Yuki、Menju Toshi、Kawaguchi Kosuke、Hosoe Yuko、Taki Mana、Murakami Ryusuke、Yamaguchi Ken、Hamanishi Junzo、Mandai Masaki
- Journal Title
  
  Experimental & Molecular Medicine
  
  Volume: 56 Issue: 12 Pages: 2659-2672
- DOI
  10.1038/s12276-024-01356-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21432, KAKENHI-PROJECT-23K21473, KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-23K15834, KAKENHI-PROJECT-24K12601
[Journal Article] Clinical significance of initial symptoms in endometriosis-associated ovarian cancer2024
- Author(s)
  Ono Maaya、Fukuda Mayu、Yamanoi Koji、Sunada Masumi、Kitamura Sachiko、Taki Mana、Horie Akihito、Yamaguchi Ken、Hamanishi Junzo、Mandai Masaki
- Journal Title
  
  Journal of Turkish Society of Obstetric and Gynecology
  
  Volume: 21 Issue: 1 Pages: 28-36
- DOI
  10.4274/tjod.galenos.2024.59019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21473
[Journal Article] YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma2024
- Author(s)
  Furutake Yoko、Yamaguchi Ken、Yamanoi Koji、Kitamura Sachiko、Takamatsu Shiro、Taki Mana、Ukita Masayo、Hosoe Yuko、Murakami Ryusuke、Abiko Kaoru、Horie Akihito、Hamanishi Junzo、Baba Tsukasa、Matsumura Noriomi、Mandai Masaki
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 23 Issue: 11 Pages: 1652-1665
- DOI
  10.1158/1535-7163.mct-24-0145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09514, KAKENHI-PROJECT-23K27741, KAKENHI-PROJECT-24K12539
[Journal Article] A deep learning-based assessment pipeline for intraepithelial and stromal tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma2024
- Author(s)
  Hamada Kohei、Murakami Ryusuke、Ueda Akihiko、Kashima Yoko、Miyagawa Chiho、Taki Mana、Yamanoi Koji、Yamaguchi Ken、Hamanishi Junzo、Minamiguchi Sachiko、Matsumura Noriomi、Mandai Masaki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: - Issue: 7 Pages: 1272-1284
- DOI
  10.1016/j.ajpath.2024.02.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27741, KAKENHI-PROJECT-23K21473, KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-22K09610, KAKENHI-PROJECT-24K12601, KAKENHI-PROJECT-24KJ1404
[Journal Article] Development of healthy lifestyle consciousness index for gynecological cancer patients2022
- Author(s)
  Higashiyama Nozomi、Yamaguchi Ken、Yamamoto Yosuke、Ueda Akihiko、Inayama Yoshihide、Egawa Miho、Yamanoi Koji、Taki Mana、Ukita Masayo、Hosoe Yuko、Horie Akihito、Hamanishi Junzo、Mandai Masaki
- Journal Title
  
  Supportive Care in Cancer
  
  Volume: 30 Issue: 9 Pages: 7569-7574
- DOI
  10.1007/s00520-022-07179-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-23K21473
[Journal Article] Nivolumab for malignant transformation of ovarian mature cystic teratoma2022
- Author(s)
  Yoshimura Kayoko、Yamanoi Koji、Kanai Masashi、Okunomiya Asuka、Sagae Yusuke、Sunada Masumi、Taki Mana、Ukita Masayo、Chigusa Yoshitsugu、Horie Akihito、Yamaguchi Ken、Hamanishi Junzo、Minamiguchi Sachiko、Yamamoto Noboru、Muto Manabu、Mandai Masaki
- Journal Title
  
  Gynecologic Oncology Reports
  
  Volume: 44 Pages: 101115-101115
- DOI
  10.1016/j.gore.2022.101115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-23K21473
[Journal Article] Mutation burden-orthogonal tumor genomic subtypes delineate responses to immune checkpoint therapy2022
- Author(s)
  Takamatsu Shiro、Hamanishi Junzo、Brown J B、Yamaguchi Ken、Yamanoi Koji、Murakami Kosuke、Gotoh Osamu、Mori Seiichi、Mandai Masaki、Matsumura Noriomi
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 7 Pages: e004831-e004831
- DOI
  10.1136/jitc-2022-004831
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-23K21473
[Presentation] 腫瘍環境・フェロトーシスをターゲットにした卵巣明細胞癌の新規治療戦略2024
- Author(s)
  山口　建、古武　陽子、姜　夢心（Jiang Mengxin）、山ノ井　康二、滝　真奈、村上　隆介、植田　彰彦、濵西　潤三、万代　昌紀
- Organizer
  第66回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09514
[Presentation] 卵巣明細胞癌においてZDHHC7によるYAP1の抑制はferroptosis抵抗性と予後不良に関係する2024
- Author(s)
  古武陽子、山口建、北村幸子、滝真奈、山ノ井康二、村上隆介、濵西潤三、万代昌紀
- Organizer
  第66回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09514
[Presentation] Elucidating the influence of long-chain fatty acids on ovarian cancer progression2023
- Author(s)
  Jumpei Ogura; Koji Yamanoi; Mana Taki; Ryusuke Murakami; Ken Yamaguchi; Junzo Hamanishi; Masaki Mandai
- Organizer
  AACR Ovarian cancer club 2023
- Data Source
  KAKENHI-PROJECT-23K15834
[Presentation] Stearic acid may induce apoptosis via DNA damage to ovarian cancer cells.2022
- Author(s)
  小椋淳平、山ノ井康二
- Organizer
  第64回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18166
[Presentation] Stearic acid, a long-chain fatty acid, may induce apoptosis through the accumulation of DNA damage in ovarian cancer cells.2022
- Author(s)
  小椋淳平、山ノ井康二
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18166
[Presentation] The effect of high-fat-diet on acquisition of malignant phenotypes of ovarian cancer through elevation of long chain fatty acid.2021
- Author(s)
  小椋淳平、山ノ井康二
- Organizer
  第73回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18166
[Presentation] ZDHHC7 contributes to ferroptosis resistance through YAP localization in ovarian clear cell carcinoma2021
- Author(s)
  Yoko Furutake, Ken Yamguchi, Masayo Ukita, Mana Taki, Koji Yamanoi, Junzo Hamanishi, Takashi Kobayashi, Masaki Mandai
- Organizer
  The AACR Annual Meeting
- Data Source
  KAKENHI-PROJECT-21K09514
[Presentation] The effect of high-fat-diet on malignant phenotypes of ovarian cancer through elevation of long chain fatty acid.2021
- Author(s)
  小椋淳平、山ノ井康二
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K18166
[Presentation] ZDHHC7 contributes to ferroptosis resistance through Hippo signaling in ovarian clear cell carcinoma2021
- Author(s)
  Yoko Furutake, Ken Yamguchi, Sachiko Kitamura, Mana Taki, Koji Yamanoi, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai
- Organizer
  日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09514
[Presentation] ZDHHC7 contributes to ferroptosis resistance through Hippo signaling in ovarian clear cell carcinoma2021
- Author(s)
  Yoko Furutake, Ken Yamaguchi, Sachiko Kitamura, Mana Taki, Koji Yamanoi, Junzo Hamanishi, Masaki Mandai
- Organizer
  日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09514
[Presentation] The effect of high-fat-diet on malignant phenotypes of ovarian cancer cells through elevation of unsaturated fatty acid.2021
- Author(s)
  小椋淳平、山ノ井康二
- Organizer
  第63回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18166
[Presentation] ZDHHC7 contributes to ferroptosis resistance through YAP localization in ovarian clear cell carcinoma2021
- Author(s)
  Yoko Furutake, Ken Yamaguchi, Koji Yamanoi, Mana Taki, Masayo Ukita, Junzo Hamanishi, Masaki Mandai
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09514

1. Yamaguchi Ken (20378772)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Mandai Masaki (80283597)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. 馬場長 (60508240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 滝真奈 (20898077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. Kitamura Sachiko (10846140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三瀬名丹 (00360644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井沢知子 (50538436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 増島麻里子 (40323414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川口展子 (60771540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 濱西潤三 (80378736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 河本宏 (00343228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 奥野恭史 (20283666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 安彦郁 (20508246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 村上隆介 (40782363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 茶本健司 (50447041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 加藤侑希 (60733649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岩田卓 (30296652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 久保亜紀子 (50455573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 平井宗一 (70516054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 飯田美穂 (70594505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小松宏彰 (20866727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小原久典 (30598818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 中川慧 (30650593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 樋本祐紀 (30838991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 山本洋介 (30583190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大澤毅 (50567592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MATSUMURA Noriomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 中西祐貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamanoi Koji 山ノ井 康二

Research Projects

Research Products

Co-Researchers

Development of an innovative early cancer diagnosis system targeting fatty acid metabolic reprogramming.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臨床所見やゲノム情報など多様なデータを駆使した子宮頸癌悪性度予測モデル構築の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of tertiary lymphoid structures (TLS) in gynecological cancer and basic investigation of new treatment development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

婦人科がん患者のQOLや治療成績に関わる食事と腸内細菌叢・代謝物の探索的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism by which stearic acid suppresses ovarian cancer cell proliferation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of a program to promote adherence to compression therapy in elderly patients with lower limb lymphedema.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Ferotosis based on Lipid Metabolism in Endometriosis and Ovarian Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of nucleic acid metabolism to establish a a new therapeutic strategy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidatinon of the mechanism by wihch fatty acids alter the malignant features of ovarian cancer int terms of palmitoylation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in uterine carcinosarcoma2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of initial symptoms in endometriosis-associated ovarian cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma2024

Author(s)

Yamanoi Koji 山ノ井康二