Kobara Hisanori 小原久典

… Alternative Names

小原久典コバラヒサノリ

KOBARA Hisanori 小原久典

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Researcher Number	30598818
Affiliation (Current)	2025: 信州大学, 学術研究院医学系(医学部附属病院), 講師
Affiliation (based on the past Project Information) *help	2025: 信州大学, 学術研究院医学系(医学部附属病院), 講師 2022 – 2023: 信州大学, 学術研究院医学系, 助教 2017 – 2019: 信州大学, 学術研究院医学系, 助教 2014 – 2015: 信州大学, 学術研究院医学系, 助教 2013: 信州大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator 婦人科腫瘍学 / がん幹細胞マーカー / CD44 variant / NRF2 / 明細胞癌 / 卵巣癌 / 抗酸化物質 / 酸化ストレス / CD133 / CD44 … More / 酸化ストレス耐性 / 卵巣明細胞癌 / 卵巣子宮内膜症性嚢胞 / Lipocalin2 / 浸潤能酸素濃度 / E-cadherin / 酸素濃度 / 浸潤能 / 妊娠初期 / MMP-9活性 / 絨毛外トロフォブラスト / lipocalin2 … More Except Principal Investigator MRI画像 / 子宮頸がん / 鑑別診断 / 臨床鑑別診断 / 子宮頸部多発嚢胞 / 子宮頸部胃型粘液性癌 / 傍神経浸潤 / 深層学習 / 人工知能 / MRI / 分葉状頸管腺過形成 / 子宮頸部胃型腺癌 / 子宮頸部多発のう胞 / 造腫瘍能 / マイクロアレイ / 癌幹細胞マーカー / 抗癌剤耐性 / 子宮内膜癌 / lipocalin2 Less

臨床所見やゲノム情報など多様なデータを駆使した子宮頸癌悪性度予測モデル構築の試み
- Principal Investigator
  
  山ノ井康二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Research on differential diagnosis of cervical multi-cystic lesions by artificial intelligence
- Principal Investigator
  
  宮本強
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Shinshu University
Elucidation of the mechanism of oxidative stress tolerance by Lipocalin2 in ovarian clear cell carcinoma and development of treatment methodsPrincipal Investigator
- Principal Investigator
  
  Kobara Hisanori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Study for development of the therapy targeting the novel oncogene lipocalin2 in endometrial carcinoma
- Principal Investigator
  
  MIYAMOTO Tsutomu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
The expression and function of LCN2 in the extravillous trophoblastPrincipal Investigator
- Principal Investigator
  
  KOBARA Hisanori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University

All 2022 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Biology and management of lobular endocervical glandular hyperplasia2022
- Author(s)
  Miyamoto Tsutomu、Kobara Hisanori、Shiozawa Tanri
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 48 Issue: 12 Pages: 3056-3067
- DOI
  10.1111/jog.15441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09593
[Journal Article] Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.2016
- Author(s)
  Miyamoto T, Kashima H, Yamada Y, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0155220-e0155220
- DOI
  10.1371/journal.pone.0155220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
[Journal Article] Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.2016
- Author(s)
  Yamada Y, Miyamoto T, Kashima H, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Shiozawa T.
- Journal Title
  
  Free Radic Res.
  
  Volume: 50 Issue: 4 Pages: 414-25
- DOI
  10.3109/10715762.2015.1134795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25861484, KAKENHI-PROJECT-25293339
[Journal Article] Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.2015
- Author(s)
  Asaka R, Miyamoto T, Yamada Y, Ando H, Mvunta DH, Kobara H, Shiozawa T
- Journal Title
  
  Lab Invest
  
  Volume: 95 Issue: 12 Pages: 1363-73
- DOI
  10.1038/labinvest.2015.119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10711, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
[Journal Article] Recurrent low-grade endometrial stromal sarcoma with intracaval and intracardiac tumor thrombus: diagnosis, treatment, and surgical management2014
- Author(s)
  Miyamoto T, Tachibana R, Kobara H, Takano T, Kato H, Shimizu A, Ohya A, Uehara T, Shiozawa T.
- Journal Title
  
  International Cancer Conference Journal
  
  Volume: 3 Issue: 1 Pages: 1-7
- DOI
  10.1007/s13691-013-0134-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670699, KAKENHI-PROJECT-25861483
[Journal Article] 妊娠初期に診断し保存的に治療し得た腹腔妊娠の1例2014
- Author(s)
  今西俊明, 宮本強, 古川哲平, 岡賢二, 鹿島大靖, 橘涼太, 小原久典, 芦田敬, 近藤沙織, 塩沢丹里
- Journal Title
  
  関東連合産科婦人科学会誌
  
  Volume: 51 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861483
[Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013
- Author(s)
  Kobara H, Miyamoto T, Suzuki A, Asaka R, Yamada Y, Ishikawa K, Kikuchi N, Ohira S, Shiozawa T.
- Journal Title
  
  Placenta
  
  Volume: 34(11) Issue: 11 Pages: 1036-43
- DOI
  10.1016/j.placenta.2013.08.004
- Data Source
  KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670698, KAKENHI-PROJECT-25861483, KAKENHI-PROJECT-25861484
[Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013
- Author(s)
  Miyamoto T
- Journal Title
  
  Histopathology
  
  Volume: Feb 9 [Epub ahead of print] Issue: 7 Pages: 986-93
- DOI
  10.1111/his.12107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390310, KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25861483
[Journal Article] Placental mesenchymal dysplasia: chronological observation of placental images during gestation and review of the literature.2013
- Author(s)
  Ohira S, Ookubo N, Tanaka K, Takatsu A, Kobara H, Kikuchi N, Ohya A, Kanai M, Shiozawa T
- Journal Title
  
  Gynecol Obstet Invest
  
  Volume: 75(4) Issue: 4 Pages: 217-23
- DOI
  10.1159/000350661
- NAID
  120007107419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-25460794, KAKENHI-PROJECT-25670698, KAKENHI-PROJECT-25861483
[Presentation] 同一症例の分葉状頸管腺過形成と胃型粘液性癌と全エクソーム配列による解析2022
- Author(s)
  宮本強, 田中泰裕, 井田耕一, 小原久典, 山田靖, 品川真奈花, 小野元紀, 浅香亮一, 塩沢丹里
- Organizer
  日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K09593
[Presentation] Lipocalin2は妊娠初期絨毛外トロフォブラストの細胞浸潤能を促進する2013
- Author(s)
  小原久典、宮本　強、菊地範彦、石川香織、山田　靖、浅香亮一、鈴木昭久、大平哲史、塩沢丹里
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25861483
[Presentation] Lipocalin2は子宮内膜癌において新規癌遺伝子として作用する2013
- Author(s)
  宮本　強、山田　靖、浅香亮一、安藤大史、石川香織、小原久典、鈴木昭久、塩沢丹里
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] 鉄運搬に関わるLipocalin2は、子宮内膜癌で新規がん遺伝子として機能する2013
- Author(s)
  宮本　強、浅香亮一、山田　靖、小原久典、石川香織、鈴木昭久、塩沢丹里
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] Lipocalin2 accelerates tumor growth and functions as a novel onvogene in endometrial carcinoma cell.2013
- Author(s)
  Miyamoto T,Yamada Y,Kobara H,Asaka R,Ando H,Ishikawa K,David Hamisi Mvunta,Suzuki A,Shiozawa T.
- Organizer
  第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] Lipocalin2は低酸素環境でMMP-9活性と絨毛外トロフォブラストの浸潤を亢進させる
- Author(s)
  小原久典、宮本　強、浅香亮一、山田　靖、塩沢丹里
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪　千里ライフサイエンスセンター
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25861483
[Presentation] Lipocalin2,an iron transporter,functions as a novel oncogene and enhances the proliferation and survival of endometrial carcinoma cell
- Author(s)
  Miyamoto T,Asaka R, Yamada Y,Ishikawa k, Kobara H,Suzuki A,Shiozawa T.
- Organizer
  American Assosiation for Cancer Research Annual Meeting 2013
- Place of Presentation
  ワシントンD.C（アメリカ）
- Data Source
  KAKENHI-PROJECT-25293339

1. MIYAMOTO Tsutomu (70418721)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. SHIOZAWA Tanri (20235493)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. YAMADA Yasushi (60646652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 鹿島大靖 (70464089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小野元紀 (10816432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大彌歩 (60837079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山ノ井康二 (70868075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小松宏彰 (20866727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中川慧 (30650593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 樋本祐紀 (30838991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUZUKI Akihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. TAKATSU Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobara Hisanori 小原 久典

小原 久典 コバラ ヒサノリ

KOBARA Hisanori 小原 久典

Research Projects

Research Products

Co-Researchers

臨床所見やゲノム情報など多様なデータを駆使した子宮頸癌悪性度予測モデル構築の試み

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on differential diagnosis of cervical multi-cystic lesions by artificial intelligence

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of oxidative stress tolerance by Lipocalin2 in ovarian clear cell carcinoma and development of treatment methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for development of the therapy targeting the novel oncogene lipocalin2 in endometrial carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The expression and function of LCN2 in the extravillous trophoblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Biology and management of lobular endocervical glandular hyperplasia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recurrent low-grade endometrial stromal sarcoma with intracaval and intracardiac tumor thrombus: diagnosis, treatment, and surgical management2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 妊娠初期に診断し保存的に治療し得た腹腔妊娠の1例2014

Author(s)

Journal Title

Data Source

[Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Placental mesenchymal dysplasia: chronological observation of placental images during gestation and review of the literature.2013

Author(s)

Journal Title

DOI

NAID

Kobara Hisanori 小原久典

小原久典コバラヒサノリ

KOBARA Hisanori 小原久典