FUJITA Naoyuki 藤田直之

Researcher Number	50403192
Affiliation (based on the past Project Information) *help	2009: 熊本大学, 大学院・生命科学研究部, 准教授 2007 – 2008: Kumamoto University, 大学院・医学薬学研究部, 准教授 2007: 熊本大学, 医学薬学研究部, 准教授 2005 – 2006: 大阪大学, 医学系研究科, 助教授
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator TJ / AJ / 細胞極性因子 / Par-3 / アファディン / ネクチン / 細胞極性 / 細胞間接着 Except Principal Investigator インテグリン / 一次線毛 … More / 細胞膜変形 / 微小管結合タンパク質 / チュブリン / 初期エンドソーム / 微小管結合蛋白質 / ソーティング / 線毛 / ユビキンチン化酵素E3 / リン脂質 / ユビキチン化酵素E3 / ユビキチン / リポソーム / 中心体 / 上皮性ナトリウムチャンネル / エンドサイトーシス / クラスリン / 細胞膜 / 微小管 / Necl-5 / Necl - 5 / がん / Nec1-5 / 増殖因子受容体 / アファディン / Necl / ネクチン / 細胞極性 / 細胞接着 / 細胞運動 / 細胞増殖 Less

Cell polarization mechanisms by nectin-afadin adhesion system and Par polarity proteinsPrincipal Investigator
- Principal Investigator
  
  FUJITA Naoyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
Role of cell adhesion signaling in the abnormal cell polarization of cancer cells
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Osaka University
Interactions of transportsome and cytoskeleton
- Principal Investigator
  
  NAKANISHI Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University

All 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.2009
- Author(s)
  Miyata M, Ogita H, Komura H, Nakata S, Okamoto R, Ozaki M, Majima T, Matsuzawa N, Kawano S, Minami A, Waseda M, Fujita N, Mizutani K, Rikitake Y, Takai Y.
- Journal Title
  
  J Cell Sci 122
  
  Pages: 4319-4329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions.2007
- Author(s)
  Ooshio T, Fujita N, Yamada A, Sato T, Kitagawa Y, Okamoto R, Nakata S, Miki A, Irie K, Takai Y.
- Journal Title
  
  J Cell Sci 120
  
  Pages: 2352-2365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology.2007
- Author(s)
  Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 37815-37825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Journal Article] The roles of nectins in cell adhesions : cooperation with other cell adhesion molecules and growth factor receptors.2007
- Author(s)
  Sakisaka T, Ikeda W, Ogita H, Fujita N, Takai Y.
- Journal Title
  
  Curr Opin Cell Biol 19
  
  Pages: 593-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions2007
- Author(s)
  Ooshio T, Fujita N, Yamada A, Sato T, Kitagawa Y, Okamoto R, Nakata S, Miki A, Irie K, Takai Y.
- Journal Title
  
  J. Cell Sci 120
  
  Pages: 2352-2365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590276
[Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology2007
- Author(s)
  Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y.
- Journal Title
  
  J.Biol. Chem 282
  
  Pages: 37815-27825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590276
[Journal Article] The roles of nectins in cell adhesions : cooperation with other cell adhesion molecules and growth factor receptors2007
- Author(s)
  Sakisaka T, Ikeda W, Ogita H, Fujita N, Takai Y.
- Journal Title
  
  Curr. Opin. Cell Biol 19
  
  Pages: 593-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590276
[Journal Article] Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby Canine Kidney Cells.2006
- Author(s)
  Sato T, Fujita N, Yamada A, Ooshio T, Okamoto R, Irie K, Takai, Y.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 5288-5299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Journal Article] Requirement of nectin, but not cadherin, for formation of claudin- based tight junctions in annexin II- knockdown MDCK cells.2006
- Author(s)
  Yamada A, Fujita N, Sato T, Okamoto R, Ooshio T, Hirota T, Morimoto K, Irie K, Takai Y.
- Journal Title
  
  Oncogene 25
  
  Pages: 5085-5102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014055
[Presentation] 新しいリン脂質結合タンパク質SGIP1αによる初期エンドソームでのEGF受容体のソーティング2008
- Author(s)
  上江洲章吉、菊池直也、梅田一彰、藤田直之、中西宏之
- Organizer
  BMB2008(熊大・院・医学薬学研究部・細胞情報薬理学)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19590276
[Presentation] Binding of afadin to SHP-2 stimulates dephosphorylation of PDGF receptor and inhibits the PDGF-induced Ras activation2007
- Author(s)
  中田信輔、藤田直之、北川雄一、扇田久和、高井義美
- Organizer
  第66回日本癌学会学術総会(阪大院・分子生物学、神大院・医・分子細胞生物学)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19590276
[Presentation] New cross-talk mechanisms of cell adhesion, migration and proliferation.2006
- Author(s)
  高井義美, 池田わたる, 扇田久和, 匂坂敏朗, 藤田直之
- Organizer
  The 10th International Symposium on Cancer Chemotherapy "Growth Signal, Drug Resistance and Metastasis in the Development of Molecular Cancer Therapeutics"
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-17014055
[Presentation] Regulation of cell polarization, movement, and proliferation by cell-cell adhesion molecule nectin.2006
- Author(s)
  高井義美, 藤田直之, 扇田久和, 池田わたる
- Organizer
  20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-17014055
[Presentation] Cross-talk signaling between cell adhesion and cell movement and proliferation2005
- Author(s)
  高井義美、池田わたる、扇田久和、匂坂敏朗、藤田直之
- Organizer
  第78回日本生化学会大会(シンポジウム)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17014055

1. UEZU Akiyoshi (70363520)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAKAI Yoshimi (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. OGITA Hisakazu (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. RIKITAKE Yoshiyuki (50419488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TOGASHI Hideru (90415240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAKISAKA Toshiaki (80359843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. OKAMOTO Miki (20332455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. NAKANISHI Hiroyuki (80314318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UMEDA Kazuaki (80444876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 池田わたる (90362699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

FUJITA Naoyuki 藤田 直之

Research Projects

Research Products

Co-Researchers

Cell polarization mechanisms by nectin-afadin adhesion system and Par polarity proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of cell adhesion signaling in the abnormal cell polarization of cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interactions of transportsome and cytoskeleton

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.2009

Author(s)

Journal Title

Data Source

[Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions.2007

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology.2007

Author(s)

Journal Title

Data Source

[Journal Article] The roles of nectins in cell adhesions : cooperation with other cell adhesion molecules and growth factor receptors.2007

Author(s)

Journal Title

Data Source

[Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions2007

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology2007

Author(s)

Journal Title

Data Source

[Journal Article] The roles of nectins in cell adhesions : cooperation with other cell adhesion molecules and growth factor receptors2007

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby Canine Kidney Cells.2006

Author(s)

Journal Title

Data Source

[Journal Article] Requirement of nectin, but not cadherin, for formation of claudin- based tight junctions in annexin II- knockdown MDCK cells.2006

Author(s)

Journal Title

Data Source

[Presentation] 新しいリン脂質結合タンパク質SGIP1αによる初期エンドソームでのEGF受容体のソーティング2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Binding of afadin to SHP-2 stimulates dephosphorylation of PDGF receptor and inhibits the PDGF-induced Ras activation2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] New cross-talk mechanisms of cell adhesion, migration and proliferation.2006

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Regulation of cell polarization, movement, and proliferation by cell-cell adhesion molecule nectin.2006

Author(s)

Organizer

Place of Presentation

Data Source

FUJITA Naoyuki 藤田直之