SAKATANI Takashi 坂谷貴司

… Alternative Names

坂谷貴司サカタニタカシ

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Researcher Number	50431903
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 日本医科大学, 医学部, 教授 2016 – 2020: 日本医科大学, 医学部, 教授 2012: 東京大学, 大学院・医学系研究科, 助教 2010: 自治医科大学, 医学部, 准教授 2008 – 2009: The University of Tokyo, 医学部附属病院, 助教 … More 2008: The University of Tokyo, 医学部・附属病院, 助教 2007: The University of Tokyo, Graduate School of Medicine, Research Associate 2006: 東京大学, 大学院医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Human pathology / Basic Section 50010:Tumor biology-related / Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Keywords	Principal Investigator エピジェネティクス / 腫瘍 / マイクロRNA / 乳腺 / 病理学 / 消化器 / 細胞接着 / microRNA / Epstein-Barr ウイルス関連胃癌 / 胃癌 … More Except Principal Investigator … More 乳癌 / 血管新生 / 術前内分泌療法 / 胃癌細胞株 / 幹細胞 / 胃癌 / EBウイルス / EBウイルス関連胃癌 / 糖代謝 / 腫瘍免疫 / 術前化学療法 / 細胞形態 / レスポンスガイドセラピー / 効果予測 / 静脈侵襲 / リンパ管侵襲 / リンパ節転移 / Progesterone receptor / Estrogen receptor / 無再発生存期間 / 無増悪生存期間 / Ki67標識率 / 腫瘍浸潤リンパ球 / エストロゲン受容体 / 癌幹細胞 / Breast cancer / 転移 / 細胞増殖 / 2量体 / delta-HER2 / proliferation / stem cell / isoform / splice variant / breast cancer / 増殖 / スプライスバリアント / HER2 / gastric carcinoma cell line / carcinogenesis / promoter / DNA methylation / infectious agent and host interaction / gastric carcinoma / Epstein-Barr virus / EBV-associated gastric carcinoma / 発癌 / プロモーター / DNAメチル化 / 病原体・宿主相互作用 / 上皮間葉転換 / miR200 / RRM2 / 転写因子 / STAT3 / DNMT1 / エクソソーム / マイクロRNA / トランスジェニックマウス / SP細胞 / LMP2A / エピジェネティクス Less

A study on clinical implementation of response guided therapy with neoadjuvant endocrine therapy for breast cancer.
- Principal Investigator
  
  武井寛幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nippon Medical School
New predictive markers of effectiveness of neoadjuvant endocrine therapy of breast cancer by analyzing tumor angiogenesis
- Principal Investigator
  
  Takei Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nippon Medical School
Treatment strategy for suppression of cancer stem cell in breast cancer
- Principal Investigator
  
  Wada Ryuichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nippon Medical School
乳癌におけるマイクロRNA発現制御機構の解明Principal Investigator
- Principal Investigator
  
  坂谷貴司
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
  The University of Tokyo
EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.
- Principal Investigator
  
  FUKAYAMA Masashi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo
Molecular Mechanism for Regulation of microRNA Expression in Gastrointestinal CancerPrincipal Investigator
- Principal Investigator
  
  SAKATANI Takashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo
Carcinogenesis of EB virus-associated gastric carcinoma. Mutual DNA-methylation of host and infective agent.
- Principal Investigator
  
  FUKAYAMA Masashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2011 2010 2009 2008 Other

All Journal Article Presentation Other

[Journal Article] Cytomorphological Disparities in Invasive Breast Cancer Cells following Neoadjuvant Endocrine Therapy and Chemotherapy2024
- Author(s)
  Hoshina Hideko、Sakatani Takashi、Kawamoto Yoko、Ohashi Ryuji、Takei Hiroyuki
- Journal Title
  
  Pathobiology
  
  Volume: - Issue: 4 Pages: 1-11
- DOI
  10.1159/000538227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07218
[Journal Article] 術前薬物療法によりHER2過剰発現が陽性化した症例の検討2023
- Author(s)
  山川珠実，武井寛幸，片山結美香，加藤世奈，小林光希，佐野恵美，范姜明志，栗田智子，坂谷貴司，大橋隆治
- Journal Title
  
  乳癌基礎研究
  
  Volume: 32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07218
[Journal Article] Neoadjuvant Endocrine Therapy for Operable Breast Cancer: A Retrospective Analysis of Real-World Use2021
- Author(s)
  Iwamoto Miki、Takei Hiroyuki、Ninomiya Jun、Asakawa Hideki、Kurita Tomoko、Yanagihara Keiko、Iida Shinya、Sakatani Takashi、Ohashi Ryuji
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 88 Issue: 5 Pages: 448-460
- DOI
  10.1272/jnms.JNMS.2021_88-603
- NAID
  130008117323
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2021-10-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08583
[Journal Article] In vitro and in vivo studies on the association of long non?coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5?fluorouracil in rectal cancer2019
- Author(s)
  Yokoyama Yasuyuki、Sakatani Takashi、Wada Ryuichi、Ishino Kousuke、Kudo Mitsuhiro、Koizumi Michihiro、Yamada Takeshi、Yoshida Hiroshi、Naito Zenya
- Journal Title
  
  International Journal of Oncology
  
  Volume: 55 Pages: 1361-1371
- DOI
  10.3892/ijo.2019.4895
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09160, KAKENHI-PROJECT-16K10479
[Journal Article] Toll like receptor 4 plays a tumor suppressive role in cutaneous squamous cell carcinoma.2019
- Author(s)
  Mikami E, Kudo M, Ohashi R, Kawahara K, Kawamoto Y, Teduka K, Fujii T, Kitamura T, Kure S, Ishino K, Sakatani T, Wada R, Saeki H, and Naito Z
- Journal Title
  
  Int J Oncol
  
  Volume: 53 Pages: 2179-2188
- DOI
  10.3892/ijo.2019.4790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10479
[Journal Article] Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.2019
- Author(s)
  Hotta M, Sakatani T, Ishino K, Wada R, Kudo M, Yokoyama Y, Yamada T, Yoshida H, Naito Z
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 519 Issue: 4 Pages: 824-831
- DOI
  10.1016/j.bbrc.2019.09.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10479, KAKENHI-PROJECT-17K15673
[Journal Article] Transcriptional factor typing with SOX2, HNF4aP1, and CDX2 closely relates to tumor invasion and Epstein-Barr virus status in gastric cancer2011
- Author(s)
  Uozaki H, Barua RR, Minhua S, Ushiku T, Hino R, Shinozaki A,Sakatani T, Fukayama M
- Journal Title
  
  International Journal of Clinicaland Experimental Pathology
  
  Volume: Vol.4 Pages: 230-240
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071656/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Downregulation of microRNA-200 in EBV-associated gastric carcinoma.2010
- Author(s)
  Shinozaki A, Sakatani T, Ushiku T, Hino R, Isogai M, Ishikawa S, Uozaki H, Takada K, Fukayama M.
- Journal Title
  
  Cancer Research. 70巻
  
  Pages: 4719-4727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Expression of ribonucleotide reductase M2subunit in gastric cancer and effects of RRM2 inhibition in vitro2010
- Author(s)
  Morikawa T, Hino R, Uozaki H, Maeda D, Ushiku T, Shinozaki A,Sakatani T, Fukayama M
- Journal Title
  
  Human Pathology
  
  Volume: Vol.41 Issue: 12 Pages: 1742-1748
- DOI
  10.1016/j.humpath.2010.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022, KAKENHI-PROJECT-22890037
[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M.
- Journal Title
  
  Cancer Research. 69巻
  
  Pages: 2766-2774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S,Morikawa T, Nakaya T, Sakatani T,Takada K, Fukayama M
- Journal Title
  
  Cancer Research
  
  Volume: 69 Issue: 7 Pages: 2766
- DOI
  10.1158/0008-5472.can-08-3070
- URL
  https://pure.teikyo.jp/en/publications/4984d9ad-dd81-4149-a664-51bf36dc5c17
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Epstein-Barr virus-associated gastric carcinoma: A distinct carcinoma of gastric phenotype by claudin expression profiling2009
- Author(s)
  Shinozaki A, Ushiku T, Morikawa T, Hino R, Sakatani T, Uozaki H,Fukayama M
- Journal Title
  
  Journal of Histochemistry and Cytochemistry
  
  Volume: 57 Issue: 8 Pages: 775
- DOI
  10.1369/jhc.2009.953810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Epstein-Barr virus-associated gastric carcinoma : a distinct carcinoma of gastric phenotype by claudin expression profiling.2009
- Author(s)
  Shinozaki A, Ushiku T, Morikawa T, HinoR, Sakatani T, Uozaki H, Fukayama M.
- Journal Title
  
  Journal of Histochemistry and Cytochemistry. 57巻
  
  Pages: 75-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] 胃癌でのDNAメチル化異常2008
- Author(s)
  坂谷貴司ら
- Journal Title
  
  分子消化器病 5
  
  Pages: 358-363
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Downregulation of microRNA-200 in Epstein-Barr Virus-associated Gastric Carcinoma.
- Author(s)
  Shinozaki A*, Sakatani T*(* equal contribution), Ushiku T, Hino R, Isogai M, Ishikawa S, Uozaki H, Takada K, Fukayama M.
- Journal Title
  
  Cancer Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790253
[Presentation] Cytomorphological disparities in invasive breast cancer cells following neoadjuvant endocrine therapy and chemotherapy.2024
- Author(s)
  Hideko Hoshina, Takashi Sakatani, Yoko Kawamoto, Ryuji Ohashi, Hiroyuki Takei
- Organizer
  第62回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07218
[Presentation] 術前内分泌療法により病理学的完全奏効が得られた乳癌の4症例2024
- Author(s)
  小林光希、武井寛幸、栗田智子、中村卓、范姜明志、坂谷貴司、大橋隆治
- Organizer
  第32回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07218
[Presentation] 術前薬物療法によりHER2発現が陽性化した症例の検討2022
- Author(s)
  山川珠実，武井寛幸，片山結美香，加藤世奈，小林光希，佐野恵美，范姜明志，栗田智子，坂谷貴司，大橋隆治
- Organizer
  第90回日本医科大学医学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07218
[Presentation] 乳癌のOncotypeDx再発スコアと臨床病理学的因子との関連性の検討2022
- Author(s)
  八木美緒, 田村美樹, 小林光希, 関谷健太, 佐野恵美, 范姜明志, 栗田智子, 坂谷貴司, 大橋隆治, 武井寛幸
- Organizer
  第30回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07218
[Presentation] 術前内分泌療法の新たな効果予測因子2020
- Author(s)
  浅川英輝、二宮淳、坂谷貴司、武井寛幸
- Organizer
  日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08583
[Presentation] 有棘細胞癌におけるTLR4の発現と機能についての検討2018
- Author(s)
  三神絵理奈, 工藤光洋, 大橋隆治, 川原清子, 河本陽子, 手塚潔, 藤井雄文, 呉壮香, 石野孔祐, 坂谷貴司, 和田龍一, 佐伯秀久, 内藤善哉
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-16K10479
[Presentation] Epstein-Barrウイルス関連胃癌におけるマイクロRNA発現異常の解析2010
- Author(s)
  坂谷貴司, ら
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] Expression of the micro- RNA family; a new role for miRNAs in the morphological changes of Epstein-Barr virus associated gastric carcinoma.2010
- Author(s)
  Takashi Sakatani, et, al.
- Organizer
  99th USCAP annual meeting
- Place of Presentation
  Washington D.C.
- Data Source
  KAKENHI-PROJECT-19790253
[Presentation] Epstein-Barrウイルス関連胃癌におけるマイクロRNA発現およびE-cadherinメチル化異常の解析2010
- Author(s)
  坂谷貴司, ら
- Organizer
  第4回日本エピジェネティクス研究会
- Place of Presentation
  米子市文化ホール(鳥取県米子市)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] Epstein-Barrウイルス関連胃癌におけるマイクロRNA発現異常の解析2010
- Author(s)
  坂谷貴司
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790253
[Presentation] Expression of the microRNA-200 family ; a new role for miRNAs in the morphological changes of Epstein-Barr virus associated gastric carcinoma.2010
- Author(s)
  Sakatani T, et al
- Organizer
  99^<th> USCAP annual meeting
- Place of Presentation
  Washington D.C., USA
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] Epstein-Barr virus蛋白LMP2Aの腫瘍形成における機能解析.2009
- Author(s)
  坂谷貴司, 他
- Organizer
  第19回日本サイトメトリー学会学術総会
- Place of Presentation
  松江松江テルサ
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBV関連胃癌におけるmiR-200 familyの低下はZEB1, ZEB2を介してCDH1の発現を抑制する2009
- Author(s)
  篠崎綾, 坂谷貴司
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790253
[]

1. FUKAYAMA Masashi (70281293)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. UOZAKI Hiroshi (10296246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. HINO Rumi (60451770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. USHIKU Tetsuo (60376415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. Takei Hiroyuki (40261846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. 瀧澤俊広 (90271220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 栗田智子 (70619204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. MORIKAWA Teppei (80451772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. KIKUCHI Yoshinao (90512260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAYA Takeo (80512277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SHINOZAKI Aya (60581824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. KUNITA Akiko (50608768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Wada Ryuichi (20260408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 村上隆介 (30267215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 米戸敏彦 (10837628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 山田岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKATANI Takashi 坂谷 貴司

坂谷 貴司 サカタニ タカシ

Research Projects

Research Products

Co-Researchers

A study on clinical implementation of response guided therapy with neoadjuvant endocrine therapy for breast cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New predictive markers of effectiveness of neoadjuvant endocrine therapy of breast cancer by analyzing tumor angiogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment strategy for suppression of cancer stem cell in breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

乳癌におけるマイクロRNA発現制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Mechanism for Regulation of microRNA Expression in Gastrointestinal CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Carcinogenesis of EB virus-associated gastric carcinoma. Mutual DNA-methylation of host and infective agent.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cytomorphological Disparities in Invasive Breast Cancer Cells following Neoadjuvant Endocrine Therapy and Chemotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 術前薬物療法によりHER2過剰発現が陽性化した症例の検討2023

Author(s)

Journal Title

Data Source

[Journal Article] Neoadjuvant Endocrine Therapy for Operable Breast Cancer: A Retrospective Analysis of Real-World Use2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] In vitro and in vivo studies on the association of long non?coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5?fluorouracil in rectal cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toll like receptor 4 plays a tumor suppressive role in cutaneous squamous cell carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.2019

Author(s)

Journal Title

DOI

Data Source

SAKATANI Takashi 坂谷貴司

坂谷貴司サカタニタカシ