NAKAYA Takeo 仲矢丈雄

Researcher Number	80512277
Other IDs
Affiliation *help	2016 – 2018 : 東京医科大学, 医学部, 助教 2015 – 2018 : 自治医科大学, 医学部, 講師 2014 : 杏林大学, 医学部, 助教 2012 – 2014 : 東京医科大学, 医学部, 助教 2012 : 東京大学, 大学院・医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Experimental pathology / Human pathology Except Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Human pathology / Experimental pathology
Keywords	Principal Investigator 大腸癌 / KLF5 / エキソソーム / KLF / KLF5阻害薬 / 癌選択的抑制治療 / microRNA / 蛋白間相互作用 / 腸上皮幹細胞 / 腸上皮 … More Except Principal Investigator KLF5 / 大腸癌 / KLF5阻害薬 / 立体構造解析 / 胃癌細胞株 / エピジェネティクス / 平滑筋ミオシン / RRM2 / 大腸がん / 癌幹細胞 / LMP2A / 蛋白複合体 / 家族性大動脈解離 / STAT3 / DNMT1 / miR200 / KLF4 / がん幹細胞 / トランスジェニックマウス / 血管老化機構 / KLF / 転写因子 / 心血管リモデリング / 胃癌 / stem cell / EBウイルス関連胃癌 / 蛋白間相互作用阻害薬 / 幹細胞 / 癌 / colon cancer / In vivo蛋白複合体解析 / 心臓リモデリング / マイクロRNA / SP細胞 / EBウイルス / 心不全 / 心‐脳‐腎臓器連関 / エクソソーム / PDK4 / 上皮間葉転換 / in silico解析 Less

Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanismOngoing
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
腸組織のKLF蛋白複合体の解明と蛋白間相互作用を抑制する新規大腸癌治療薬の開発Principal InvestigatorOngoing
- Principal Investigator
  
  仲矢丈雄
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
組織再構築転写因子KLFのin vivo蛋白複合体の解析とその阻害物質の探索Ongoing
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
  Kyorin University
Analysis of KLF5/4 complex in colon cancer development
- Principal Investigator
  
  KURODA Masahiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Development of new cancer therapy using the exosomes from patients.Principal Investigator
- Principal Investigator
  
  NAKAYA Takeo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Medical University
EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.
- Principal Investigator
  
  FUKAYAMA Masashi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 2012 2010 2009

All Journal Article Presentation Book

[Book] 化学2012
- Author(s)
  仲矢丈雄，黒田雅彦，大木忠明
- Total Pages
  5
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659166
[Journal Article] Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.2017
- Author(s)
  Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, Nagao Y, Tanaka A
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume : 165 Pages : 219-227
- DOI
  10.1016/j.jsbmb.2016.06.007
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860244, KAKENHI-PROJECT-16K08718
[Journal Article] Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction2017
- Author(s)
  Michio Nakaya,Kenji Watari,Mitsuru Tajima,Takeo Nakaya,Shoichi Matsuda,Hiroki Ohara,Hiroaki Nishihara,Hiroshi Yamaguchi,Akiko Hashimoto,Mitsuho Nishida,Akiomi Nagasaka,Yuma Horii,Hiroki Ono,Gentaro Iribe,Ryuji Inoue,Makoto Tsuda,Kazuhide Inoue,Akira Tanaka,Masahiko Kuroda,Shigekazu Nagata,Hitoshi Kurose
- Journal Title
  
  J Clin Invest
  
  Volume : 127 Pages : 383-401
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01383, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-16J03451, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-16K08718
[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation.2017
- Author(s)
  Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
- Journal Title
  
  Nature Medicine
  
  Volume : 印刷中 Pages : 611-622
- DOI
  10.1038/nm.4326
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16H05295, KAKENHI-PROJECT-16K15437, KAKENHI-PROJECT-16K09510, KAKENHI-PROJECT-16K19387
[Journal Article] Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema.2016
- Author(s)
  Ogata F
- Journal Title
  
  J Invest Dermatol
  
  Volume : 136 Pages : 706-714
- DOI
  10.1016/j.jid.2015.12.001
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PUBLICLY-15H01520, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K20306, KAKENHI-PROJECT-25460473, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16K19387
[Journal Article] Evaluation of the Human Papillomavirus mRNA Test for the detection of cervical lesions in Japan.2015
- Author(s)
  Nakayama Y, Yamada M, Kurata A, Kiseki H, Kuroda M.
- Journal Title
  
  Eur J Gynaec Oncol
  
  Volume : in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670197
[Journal Article] Fukayama M.Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membraneprotein 2A for non-transformed cells2014
- Author(s)
  Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R, Aburatani H, Fukayama M.
- Journal Title
  
  Virus Res.
  
  Volume : 174 Pages : 108-115
- DOI
  10.1016/j.virusres.2013.03.009
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25114702, KAKENHI-PROJECT-20249022, KAKENHI-PLANNED-22134003, KAKENHI-PROJECT-23890036, KAKENHI-PROJECT-24221011
[Journal Article] Multifocal Kaposiform Hemangioendothelioma in Multiple Visceral Organs: An Autopsy of 9-Day-Old Female Baby.2014
- Author(s)
  Takeo Nakaya, Kiyoko Morita, Atsushi Kurata,Tetsuo Ushiku, Takashi Igarashi, Masahiko Kuroda, Masashi Fukayama.
- Journal Title
  
  Human Pathology
  
  Volume : 45 Pages : 1773-1777
- DOI
  10.1016/j.humpath.2014.03.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Young-age-onset pancreatoduodenal carcinoma in Shwachman-Diamond syndrome.2014
- Author(s)
  Nakaya T, Kurata A, Hashimoto H, Nishimata S, Kashiwagi Y, Fujita K, Kawashima H, Kuroda M.
- Journal Title
  
  Pathol Int.
  
  Volume : 64 Pages : 75-80
- DOI
  10.1111/pin.12133
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590431, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] KLF5 regulates the integrity and oncogenicity of intestinal stem cells.2014
- Author(s)
  Nakaya T, Ogawa S, Fukayama M, Kuroda M, Nagai R.(12名11番目)
- Journal Title
  
  Cancer Reseach
  
  Volume : 74(10) Pages : 2882-91
- DOI
  10.1158/0008-5472.CAN-13-2574
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.2013
- Author(s)
  Nakaya T
- Journal Title
  
  Virus Research
  
  Volume : in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation ofDNA methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S,Morikawa T, Nakaya T, Sakatani T,Takada K, Fukayama M
- Journal Title
  
  Cancer Research
  
  Volume : Vol.69 Pages : 2766-2774
- DOI
  10.1158/0008-5472.CAN-08-3070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M.
- Journal Title
  
  Cancer Research. 69巻
  
  Pages : 2766-2774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] The protein interaction inhibitors of KLF5 suppress Wnt signalactivation selectively in colorectal cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Hiroyuki Kouji, Ryozo Nagai
- Organizer
  FASEB Science Research Conference “KLF and Sp Transcription Factors in Disease and Regenerative Medicine”
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass Village, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] The protein interaction　inhibitors　of　KLF5　suppress　Wnt　signal　activation　selectively　in　colorectal　cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Ryozo Nagai
- Organizer
  FASEB Science Research Conference ”KLF and Sp Transcription Factors in Disease and Regenerative Medicine"
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Epstein-Barrウイルス因子LMP2AのCancer Initiating Cells制御による発癌促進機構2010
- Author(s)
  仲矢丈雄, ら
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBウイルスの膜蛋白LMP2Aにより促進される発癌過程の解明2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBV-encoded protein LMP2A increases cancer stem enriched side population through activating Stat3, MEK/ERK pathways, and this promotes oncogenesis2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20249022

1. Nagai Ryozo (60207975)

# of Collaborated Projects : 3results

# of Collaborated Products : 4results
2. AIZAWA Kenichi (70436484)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
3. KURODA Masahiko (80251304)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
4. FUKAYAMA Masashi (70281293)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
5. UOZAKI Hiroshi (10296246)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
6. SAKATANI Takashi (50431903)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
7. HINO Rumi (60451770)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
8. USHIKU Tetsuo (60376415)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
9. MORIKAWA Teppei (80451772)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
10. KIKUCHI Yoshinao (90512260)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
11. SHINOZAKI Aya (60581824)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
12. KUNITA Akiko (50608768)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
13. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
14. YOKOYAMA Shigeyuki (00159229)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 宮川拓也 (50596559)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 田之倉優 (60136786)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 今井靖 (20359631)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. Kawata Hirotoshi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
19. Watabe Tetsuro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. FUJIU Katsuhito

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. MATSUMOTO Sahohime

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. NAKAYAMA Yukiteru

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
23. 石川俊平

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 仲矢道雄

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
25. 津田誠

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
26. 井上和秀

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
27. 黒瀬等

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
28. 長坂明臣

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
29. 倉田厚

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
30. 尾池雄一

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
31. 眞鍋一郎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

NAKAYA Takeo 仲矢 丈雄

Research Projects

Research Products

Co-Researchers

Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanismOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸組織のKLF蛋白複合体の解明と蛋白間相互作用を抑制する新規大腸癌治療薬の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

組織再構築転写因子KLFのin vivo蛋白複合体の解析とその阻害物質の探索Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of KLF5/4 complex in colon cancer development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new cancer therapy using the exosomes from patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 化学2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction2017

Author(s)

Journal Title

Data Source

[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the Human Papillomavirus mRNA Test for the detection of cervical lesions in Japan.2015

Author(s)

Journal Title

Data Source

NAKAYA Takeo 仲矢丈雄

[Presentation] The protein interaction　inhibitors　of　KLF5　suppress　Wnt　signal　activation　selectively　in　colorectal　cancer cells2016