Nakaya Takeo 仲矢丈雄

… Alternative Names

NAKAYA Takeo 仲矢丈雄

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Researcher Number	80512277
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 関西医科大学, 医学部, 准教授 2020 – 2023: 自治医科大学, 医学部, 准教授 2015 – 2019: 自治医科大学, 医学部, 講師 2014: 杏林大学, 医学部, 助教 2012 – 2014: 東京医科大学, 医学部, 助教 2012: 東京大学, 大学院・医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49030:Experimental pathology-related / Human pathology Except Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Basic Section 53010:Gastroenterology-related / Experimental pathology / Human pathology
Keywords	Principal Investigator KLF5 / 大腸癌 / KLF5阻害薬 / 蛋白間相互作用阻害薬 / 蛋白間相互作用阻害 / 心不全 / 転写因子 / 天然変性蛋白 / 癌分子創薬 / 蛋白間相互作用 … More / 副作用 / 転移性脳腫瘍 / 血液脳関門 / Apomorphine誘導体 / Oncocardiology / アンメットニーズ / induced helical motif / undruggable / Wntシグナル / 分子創薬 / 核内因子 / がん分子創薬 / 分子標的薬 / 新規癌治療開発 / 腫瘍 / 新規抗癌薬 / 癌選択的抑制 / ミトコンドリア / 組織幹細胞 / 腸上皮 / KLF / 癌選択的抑制治療 / 腸上皮幹細胞 / がん治療開発 / T細胞 / microRNA / 腫瘍抑制 / CD8 T細胞 / miRNA / エキソソーム / がん … More Except Principal Investigator 心不全 / 癌 / 大腸癌 / KLF5 / 膵癌 / 胸管 / リンパ管 / 特異度 / 感度 / Allred score / Prox1 / Podoplanin / ポドプラニン / 膵頭部癌 / 膵体尾部切除術 / 術前化学療法 / リンパ管侵襲 / CD31 / prox1 / podoplanin / D2-40 / 浸潤性膵管癌 / 膵体尾部癌 / 血管老化機構 / 家族性大動脈解離 / 平滑筋ミオシン / in silico解析 / 立体構造解析 / PDK4 / 蛋白複合体 / 心‐脳‐腎臓器連関 / KLF5阻害薬 / 心臓リモデリング / In vivo蛋白複合体解析 / KLF / 心血管リモデリング / 分子創薬 / 蛋白間相互作用阻害薬 / 癌幹細胞 / がん幹細胞 / 大腸がん / stem cell / colon cancer / KLF4 / 胃癌細胞株 / 上皮間葉転換 / miR200 / RRM2 / 転写因子 / STAT3 / DNMT1 / エクソソーム / 幹細胞 / マイクロRNA / トランスジェニックマウス / SP細胞 / LMP2A / エピジェネティクス / 胃癌 / EBウイルス / EBウイルス関連胃癌 Less

癌脳転移を抑制する抗腫瘍薬の分子作用機構解明Principal Investigator
- Principal Investigator
  
  仲矢丈雄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kansai Medical University
Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
膵癌リンパ管侵襲の病態解明とそれを抑制する新規治療法の開発
- Principal Investigator
  
  大城久
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jichi Medical University
Development of KLF5 inhibitors that selectively inhibit cancer and improve cardiac function and elucidation of their molecular mechanisms of actionPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Jichi Medical University
Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Elucidation of the KLF protein complex in intestinal tissues and development of new drugs to suppress protein-protein interactions for the treatment of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
  Kyorin University
Analysis of KLF5/4 complex in colon cancer development
- Principal Investigator
  
  KURODA Masahiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Development of new cancer therapy using the exosomes from patients.Principal Investigator
- Principal Investigator
  
  NAKAYA Takeo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Medical University
EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.
- Principal Investigator
  
  FUKAYAMA Masashi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo

All 2024 2022 2018 2017 2016 2015 2014 2013 2012 2010 2009 Other

All Journal Article Presentation Book Other

[Book] 化学2012
- Author(s)
  仲矢丈雄，黒田雅彦，大木忠明
- Total Pages
  5
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659166
[Journal Article] Peptide mimetic <scp>NC114</scp> induces growth arrest by preventing <scp>PKCδ</scp> activation and <scp>FOXM1</scp> nuclear translocation in colorectal cancer cells2024
- Author(s)
  Taguchi Yuki、Nakaya Takeo、Aizawa Kenichi、Noguchi Yoshiyuki、Maiya Nobuhiko、Iwamoto Chisako、Ohba Kenichi、Sugawara Minoru、Murata Masayuki、Nagai Ryozo、Kano Fumi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 14 Issue: 4 Pages: 695-720
- DOI
  10.1002/2211-5463.13784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07512
[Journal Article] Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor2022
- Author(s)
  Takeo Nakaya, Kenichi Aizawa, Yuki Taguchi, Kentaro Tsuji, Sachi Sekine, Kazuhiro Murakami, Masaji Kasai, Hirofumi Nakano, Yasumitsu Kondoh, Shingo Dan, Atsushi Yoshimori, Hiroyuki Kouji, Dai Takehara, Toru Suzuki, Hiroyuki Osada, Masayuki Murata, Akira Tanaka, and Ryozo Nagai
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 13 Issue: 4 Pages: 687-694
- DOI
  10.1021/acsmedchemlett.1c00721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07512, KAKENHI-PROJECT-19K16777
[Journal Article] Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components2017
- Author(s)
  Nakaya Takeo、Oshiro Hisashi、Takigami Ayako、Kanai Yoshihiko、Tetsuka Kenji、Hagiwara Koichi、Fujii Hirofumi、Endo Shunsuke、Tanaka Akira
- Journal Title
  
  Medicine
  
  Volume: 96 Issue: 50 Pages: e8926-e8926
- DOI
  10.1097/md.0000000000008926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08718, KAKENHI-PROJECT-16K11158
[Journal Article] Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.2017
- Author(s)
  Michio Nakaya,Kenji Watari,Mitsuru Tajima,Takeo Nakaya,Shoichi Matsuda,Hiroki Ohara,Hiroaki Nishihara,Hiroshi Yamaguchi,Akiko Hashimoto,Mitsuho Nishida,Akiomi Nagasaka,Yuma Horii,Hiroki Ono,Gentaro Iribe,Ryuji Inoue,Makoto Tsuda,Kazuhide Inoue,Akira Tanaka,Masahiko Kuroda,Shigekazu Nagata,Hitoshi Kurose
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 127 Issue: 1 Pages: 383-401
- DOI
  10.1172/jci83822
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01383, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-16J03451, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-16K08718, KAKENHI-PROJECT-15H05785, KAKENHI-PROJECT-17H01525, KAKENHI-PROJECT-15H04678
[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication2017
- Author(s)
  Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
- Journal Title
  
  Nature Medicine
  
  Volume: 印刷中 Issue: 5 Pages: 611-622
- DOI
  10.1038/nm.4326
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16H05295, KAKENHI-PROJECT-16K15437, KAKENHI-PROJECT-16K09510, KAKENHI-PROJECT-16K19387, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-17K19644, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-26287025, KAKENHI-PUBLICLY-17H05594, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-17H04171, KAKENHI-PROJECT-26461125, KAKENHI-PROJECT-17H01560
[Journal Article] Ectopic respiratory mucosa in the skin which showed the repetitive distribution of ciliated bronchogenic epithelia and squamous metaplasia2017
- Author(s)
  Nakano Naomi、Nakaya Takeo、Kamiya Koji、Komine Mayumi、Murata Satoru、Kawata Hirotoshi、Yokoyama Shigeo、Tanaka Akira、Ohtsuki Mamitaro
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 44 Issue: 11 Pages: 1327-1328
- DOI
  10.1111/1346-8138.13697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08718
[Journal Article] Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer2017
- Author(s)
  Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, Nagao Y, Tanaka A
- Journal Title
  
  Journal of Steroid Biochemistry & Molecular Biology
  
  Volume: 165 Pages: 219-227
- DOI
  10.1016/j.jsbmb.2016.06.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860244, KAKENHI-PROJECT-16K08718
[Journal Article] Renal dysplasia characterized by prominent cartilaginous metaplasia lesions in VACTERL association2017
- Author(s)
  Nakaya Takeo、Hyuga Taiju、Tanaka Yukichi、Kawai Shina、Nakai Hideo、Niki Toshiro、Tanaka Akira
- Journal Title
  
  Medicine
  
  Volume: 96 Issue: 15 Pages: e6499-e6499
- DOI
  10.1097/md.0000000000006499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08718
[Journal Article] Excess Lymphangiogenesis Cooperatively Induced by Macrophages and CD4D T Cells Drives the Pathogenesis of Lymphedema2016
- Author(s)
  Ogata F
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 136 Issue: 3 Pages: 706-714
- DOI
  10.1016/j.jid.2015.12.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PUBLICLY-15H01520, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K20306, KAKENHI-PROJECT-25460473, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16K19387, KAKENHI-PROJECT-26670405
[Journal Article] Evaluation of the Human Papillomavirus mRNA Test for the detection of cervical lesions in Japan.2015
- Author(s)
  Nakayama Y, Yamada M, Kurata A, Kiseki H, Kuroda M.
- Journal Title
  
  Eur J Gynaec Oncol
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670197
[Journal Article] KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells2014
- Author(s)
  Nakaya, T
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 10 Pages: 2882-2891
- DOI
  10.1158/0008-5472.can-13-2574
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22229006, KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Multifocal Kaposiform Hemangioendothelioma in Multiple Visceral Organs: An Autopsy of 9-Day-Old Female Baby.2014
- Author(s)
  Takeo Nakaya, Kiyoko Morita, Atsushi Kurata,Tetsuo Ushiku, Takashi Igarashi, Masahiko Kuroda, Masashi Fukayama.
- Journal Title
  
  Human Pathology.
  
  Volume: 45 Issue: 8 Pages: 1773-1777
- DOI
  10.1016/j.humpath.2014.03.019
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961
[Journal Article] Young-age-onset pancreatoduodenal carcinoma in Shwachman-Diamond syndrome.2014
- Author(s)
  Nakaya T, Kurata A, Hashimoto H, Nishimata S, Kashiwagi Y, Fujita K, Kawashima H, Kuroda M.
- Journal Title
  
  Pathol Int
  
  Volume: 64 Issue: 2 Pages: 75-80
- DOI
  10.1111/pin.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590431, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.2013
- Author(s)
  Nakaya T
- Journal Title
  
  Virus Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M.
- Journal Title
  
  Cancer Research. 69巻
  
  Pages: 2766-2774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor2022
- Author(s)
  仲矢丈雄
- Organizer
  日本癌学会　学術総会　シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07512
[Presentation] Small molecules mimicking KLF5 structure suppresses cancer cells in both in vivo and vitro without damaging normal cells.2018
- Author(s)
  Nakaya T, Tsuji K, Tanaka A, Nagai R.
- Organizer
  6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] The protein interaction inhibitors of KLF5 suppress Wnt signalactivation selectively in colorectal cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Hiroyuki Kouji, Ryozo Nagai
- Organizer
  FASEB Science Research Conference “KLF and Sp Transcription Factors in Disease and Regenerative Medicine”
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass Village, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] The protein interaction　inhibitors　of　KLF5　suppress　Wnt　signal　activation　selectively　in　colorectal　cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Ryozo Nagai
- Organizer
  FASEB Science Research Conference ”KLF and Sp Transcription Factors in Disease and Regenerative Medicine"
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Epstein-Barrウイルス因子LMP2AのCancer Initiating Cells制御による発癌促進機構2010
- Author(s)
  仲矢丈雄, ら
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBV-encoded protein LMP2A increases cancer stem enriched side population through activating Stat3, MEK/ERK pathways, and this promotes oncogenesis2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBウイルスの膜蛋白LMP2Aにより促進される発癌過程の解明2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20249022
[]
[]

1. Nagai Ryozo (60207975)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. AIZAWA Kenichi (70436484)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. KURODA Masahiko (80251304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. FUKAYAMA Masashi (70281293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. UOZAKI Hiroshi (10296246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SAKATANI Takashi (50431903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. HINO Rumi (60451770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. USHIKU Tetsuo (60376415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MORIKAWA Teppei (80451772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KIKUCHI Yoshinao (90512260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHINOZAKI Aya (60581824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KUNITA Akiko (50608768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOKOYAMA Shigeyuki (00159229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宮川拓也 (50596559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田之倉優 (60136786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 今井靖 (20359631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大城久 (60381513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 池田啓子 (10265241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 福嶋敬宜 (40384937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 魚崎英毅 (90740803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NAKAYA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 眞鍋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 河田浩敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 倉田厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakaya Takeo 仲矢 丈雄

NAKAYA Takeo 仲矢 丈雄

Research Projects

Research Products

Co-Researchers

癌脳転移を抑制する抗腫瘍薬の分子作用機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.

Principal Investigator

Project Period (FY)

Research Category

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膵癌リンパ管侵襲の病態解明とそれを抑制する新規治療法の開発

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Development of KLF5 inhibitors that selectively inhibit cancer and improve cardiac function and elucidation of their molecular mechanisms of actionPrincipal Investigator

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Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism

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Elucidation of the KLF protein complex in intestinal tissues and development of new drugs to suppress protein-protein interactions for the treatment of colorectal cancerPrincipal Investigator

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Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.

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Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure

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Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator

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Analysis of KLF5/4 complex in colon cancer development

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Development of new cancer therapy using the exosomes from patients.Principal Investigator

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EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.

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[Book] 化学2012

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Nakaya Takeo 仲矢丈雄

NAKAYA Takeo 仲矢丈雄