TAKIZAWA Naoki 滝沢直己

… Alternative Names

滝沢直己タキザワナオキ

Less

Researcher Number	50448502
Other IDs
Affiliation (Current)	2022: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2022: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2013 – 2016: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2015: (公財)微生物化学研究会, 微生物化学研究所, 研究員
Review Section/Research Field	Principal Investigator General medical chemistry / Molecular biology / Basic Section 49060:Virology-related Except Principal Investigator General medical chemistry / Molecular biology
Keywords	Principal Investigator インフルエンザウイルス / RNAウイルス / 分節化ゲノム / ゲノムパッケージング / ウイルスゲノム / RNAゲノム / 分節化ウイルス / RNA-RNA結合 / ゲノムRNA / RNA二次構造 … More / RNA高次構造 / 抗ウイルス薬 / 核酸アナログ / 天然物 … More Except Principal Investigator インフルエンザウイルス / RNAポリメラーゼ / エンドヌクレアーゼ / キャップ構造 / 質量分析フットプリント法 / 抗ウイルス薬 / 構造変化 / 翻訳制御 / microRNA / RNA結合タンパク質 / 翻訳 / RNA Less

新規核酸アナログによるRNAウイルス感染細胞内ATP合成・局在変化制御機構の解明Principal Investigator
- Principal Investigator
  
  滝沢直己
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Microbial Chemistry Research Foundation
インフルエンザウイルスゲノムRNP二次構造のウイルス増殖における機能解析Principal Investigator
- Principal Investigator
  
  滝沢直己
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Microbial Chemistry Research Foundation
Structural analysis of influenza virus segmented genome in the virionPrincipal Investigator
- Principal Investigator
  
  TAKIZAWA Naoki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
  Molecular biology
- Research Institution
  Microbial Chemistry Research Foundation
Analysis of segmented RNA genome packaging in influenza virus particlePrincipal Investigator
- Principal Investigator
  
  TAKIZAWA Naoki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
  Molecular biology
- Research Institution
  Microbial Chemistry Research Foundation
Fine-tuning of translation regulation system by RNA-binding proteins
- Principal Investigator
  
  FUJIWARA Toshinobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kinki University
  Nagoya City University
Identification of a novel inhibitor of influenza virus polymerase based on inhibition of conformational change required for cap-dependent endonuclease activity
- Principal Investigator
  
  YAMASAKI Manabu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Microbial Chemistry Research Foundation

All 2022 2021 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Anti-influenza Virus Activity of Methylthio-Formycin Distinct From That of T-7052022
- Author(s)
  Takizawa Naoki、Takada Hisashi、Umekita Maya、Igarashi Masayuki、Takahashi Yoshiaki
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 13
- DOI
  10.3389/fmicb.2022.802671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07598
[Journal Article] Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity2022
- Author(s)
  Takada Hisashi、Takizawa Naoki、Shibasaki Shouta、Asaba Hiroki、Igarashi Masayuki、Shibasaki Masakatsu、Takahashi Yoshiaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 57 Pages: 116613-116613
- DOI
  10.1016/j.bmc.2022.116613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07598
[Journal Article] A functional RNA structure in the influenza A virus ribonucleoprotein complex for segment bundling2020
- Author(s)
  Takizawa Naoki、Higashi Koichi、Kawaguchi Risa Karakida、Gotoh Yasuhiro、Suzuki Yutaka、Hayashi Tetsuya、Kurokawa Ken
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.03.05.975870
- Open Access
- Data Source
  KAKENHI-PROJECT-19K07598
[Journal Article] Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments2019
- Author(s)
  Sato Ryota、Okura Takashi、Kawahara Madoka、Takizawa Naoki、Momose Fumitaka、Morikawa Yuko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 10
- DOI
  10.3389/fmicb.2019.01857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07598
[Journal Article] A C4N4 Diaminopyrimidine Fluorophore2019
- Author(s)
  Noda, H.; Asada, Y.; Maruyama, T.; Takizawa, N.; Noda, N. N.; Shibasaki, M.; Kumagai, N.
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 25 Pages: 4299-4304
- DOI
  10.1002/chem.201900467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14878, KAKENHI-PUBLICLY-18H04276, KAKENHI-PROJECT-17H03025, KAKENHI-PROJECT-19K07598
[Journal Article] Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f287432019
- Author(s)
  Yamasaki Manabu、Igarashi Masayuki、Sawa Ryuichi、Nosaka Chisato、Umekita Maya、Hatano Masaki、Kimura Tomoyuki、Iijima Kiyoko、Takizawa Naoki、Kato Taira、Mizumoto Kiyohisa、Nomoto Akio
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 72 Pages: 125-133
- DOI
  10.1038/s41429-018-0134-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07598
[Journal Article] Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging.2019
- Author(s)
  Takizawa N, Ogura Y, Fujita Y, Noda T, Shigematsu H, Hayashi T, Kurokawa K
- Journal Title
  
  Virology.
  
  Volume: 531 Pages: 126-140
- DOI
  10.1016/j.virol.2019.03.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19K07598, KAKENHI-PROJECT-19K22529, KAKENHI-PROJECT-17H04082
[Journal Article] Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain2017
- Author(s)
  Naito T, Mori K, Ushirogawa H, Takizawa N, Nobusawa E, Odagiri T, Tashiro M, Ohniwa RL, Nagata K, Saito M.
- Journal Title
  
  Journal of virology
  
  Volume: 91 Pages: 614-614
- DOI
  10.1128/jvi.01073-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19562, KAKENHI-PROJECT-15K21607, KAKENHI-PROJECT-15K09345, KAKENHI-PROJECT-16J10490
[Journal Article] Influenza A virus hemagglutinin is required for the assembly of viral components including bundled vRNPs at the lipid raft2016
- Author(s)
  Takizawa N, Momose F, Morikawa Y, Nomoto A.
- Journal Title
  
  Viruses
  
  Volume: 8 Pages: 249-249
- DOI
  10.3390/v8090249
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21607, KAKENHI-PROJECT-16K08818
[Journal Article] MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in Humans2014
- Author(s)
  Fukao A., Mishima Y., Takizawa N., Oka S., Imataka H., Pelletier J., Sonenberg N., Thoma C. and Fujiwara T.
- Journal Title
  
  Mol. Cell
  
  Volume: 56 Pages: 79-89
- DOI
  10.1016/j.molcel.2014.09.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291007, KAKENHI-PROJECT-25871077
[Journal Article] Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation.2014
- Author(s)
  Mikami S, Kanaba T, Takizawa N, Kobayashi A, Maesaki R, Fujiwara T, Ito Y,Mishima M.
- Journal Title
  
  Structure
  
  Volume: 22 Pages: 35-46
- DOI
  10.1016/j.str.2013.10.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22121002, KAKENHI-PUBLICLY-24115715, KAKENHI-PUBLICLY-24121722, KAKENHI-PUBLICLY-25117723, KAKENHI-PROJECT-25291007, KAKENHI-PROJECT-25650025, KAKENHI-PROJECT-25670151, KAKENHI-PROJECT-25871077
[Journal Article] The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae2013
- Author(s)
  Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Ayako Saito, Akira Fukao, Akio Nomoto, Kiyobisa Mizumoto
- Journal Title
  
  PLoS One
  
  Volume: 8(10)
- DOI
  10.1371/journal.pone.0078000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02416, KAKENHI-PROJECT-23390113, KAKENHI-PUBLICLY-24115715, KAKENHI-PROJECT-24659139, KAKENHI-PROJECT-25291007, KAKENHI-PROJECT-25670151, KAKENHI-PROJECT-25871077
[Presentation] A functional RNA structure in the influenza A virus ribonucleoprotein complex2021
- Author(s)
  滝沢直己
- Organizer
  第22回日本RNA学会
- Data Source
  KAKENHI-PROJECT-19K07598
[Presentation] インフルエンザウイルスRNAゲノムの粒子内配置解明による分節識別機構の解明2019
- Author(s)
  滝沢直己
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07598
[Presentation] インフルエンザウイルスゲノムRNA二次構造の網羅的同定と機能解析2019
- Author(s)
  滝沢直己
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K07598
[Presentation] インフルエンザウイルスRNAゲノムの網羅的構造解析と機能2019
- Author(s)
  滝沢直己
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07598
[Presentation] 効率的なゲノムパッケージングに必要な塩基の変異によるインフルエンザウイルスゲノム RNP高次構造変化2016
- Author(s)
  滝沢　直己
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K21607
[Presentation] NGSを利用したインフルエンザウイルスゲノムRNA粒子内立体配置解析法の開発2015
- Author(s)
  滝沢　直己、小椋　義俊、林哲也、黒川　顕
- Organizer
  NGS現場の会第四回研究会
- Place of Presentation
  つくば国際会議場（つくば市）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K21607
[Presentation] Analysis of cell type specific translation from IRES mRNA derived from two different poliovirus strains2015
- Author(s)
  Akitoshi Sadahiro, Akira Fukao, Naoki Takizawa, Osamu Takeuchi, Toshinobu Fujiwara
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25291007
[Presentation] ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析2015
- Author(s)
  貞廣暁利、深尾亜喜良、滝沢直己、竹内理、藤原俊伸
- Organizer
  BMB2015 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド　（兵庫県）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25291007
[Presentation] インフルエンザウイルス分節化ゲノムRNA集合および子孫ウイルス出芽におけるウイルス膜タンパク質の機能解析2014
- Author(s)
  滝沢直己、野本明男
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（名古屋）
- Year and Date
  2014-07-23
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] インフルエンザウイルス膜タンパク質HAおよびM2のウイルス粒子形成における機能解析2014
- Author(s)
  滝沢直己、百瀬文隆、原口日和、森川裕子、野本明男
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索2013
- Author(s)
  山崎学、滝沢直己、藤原俊伸、水本清久、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-24659139
[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索
- Author(s)
  山崎学、滝沢直己、藤原俊伸、水本清久、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] HA欠損ウイルスにおけるインフルエンザウイルスゲノムの子孫粒子内取り込み機構の解析
- Author(s)
  滝沢直己、百瀬文隆、原口日和、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] Influenza A virus HA and M2 proteins are required for normal budding and genome packaging but not for normal segmented genome assembly
- Author(s)
  Naoki Takizawa, Fumitaka Momose, Hiyori Haraguchi, Yuko Morikawa, Akio Nomoto
- Organizer
  4th International Influenza Meeting
- Place of Presentation
  University of Munster (Germany)
- Year and Date
  2014-09-21 – 2014-09-23
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] インフルエンザウイルスRNAゲノムの子孫粒子内取り込み機構の解析
- Author(s)
  滝沢直己、野本明男
- Organizer
  第15回日本RNA学会年会
- Place of Presentation
  県民文化会館ひめぎんホール（愛媛）
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] 神経変性疾患の治療を目指した外来遺伝子発現ポリオウイルスベクターの開発研究
- Author(s)
  荒川正行、滝沢直己、藤原俊伸、斎藤加代子、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] インフルエンザウイルス分節化RNAゲノムの子孫粒子取り込み機構の解析
- Author(s)
  滝沢直己、野本明男
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場（神戸）
- Data Source
  KAKENHI-PROJECT-25871077
[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索
- Author(s)
  山崎学、滝沢直己、藤原俊伸、水本清久、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-24659139

1. YAMASAKI Manabu (50442570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. MIZUMOTO Kiyohisa (80092344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. FUJIWARA Toshinobu (80362804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. TOMARI Yukihide (90447368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAITO Tadasuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SAITO Mineki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 野田秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 熊谷直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 野本明男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 三島正規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森川裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 林哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 黒川顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小椋義俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 重松秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 野田岳志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKIZAWA Naoki 滝沢 直己

滝沢 直己 タキザワ ナオキ

Research Projects

Research Products

Co-Researchers

新規核酸アナログによるRNAウイルス感染細胞内ATP合成・局在変化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インフルエンザウイルスゲノムRNP二次構造のウイルス増殖における機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of influenza virus segmented genome in the virionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of segmented RNA genome packaging in influenza virus particlePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fine-tuning of translation regulation system by RNA-binding proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a novel inhibitor of influenza virus polymerase based on inhibition of conformational change required for cap-dependent endonuclease activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anti-influenza Virus Activity of Methylthio-Formycin Distinct From That of T-7052022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A functional RNA structure in the influenza A virus ribonucleoprotein complex for segment bundling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A C4N4 Diaminopyrimidine Fluorophore2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f287432019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain2017

Author(s)

Journal Title

DOI

TAKIZAWA Naoki 滝沢直己

滝沢直己タキザワナオキ