Yamasaki Manabu 山崎学

… Alternative Names

山崎学ヤマサキマナブ

YAMASAKI Manabu 山崎学

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Researcher Number	50442570
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2022 – 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2015 – 2017: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2013: (公財)微生物化学研究会, 微生物化学研究所, 研究員 2012 – 2013: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Virology / General medical chemistry Except Principal Investigator Virology
Keywords	Principal Investigator 抗ウイルス薬 / B型肝炎ウイルス / コアタンパク質 / cccDNA / 持続感染 / 微生物由来天然物 / パパイン様プロテアーゼ / メインプロテアーゼ / 天然物創薬 / SARS-CoV-2 … More / ケミカルバイオロジー / 創薬標的分子 / ゲノム複製 / 構造変化 / 質量分析フットプリント法 / キャップ構造 / エンドヌクレアーゼ / RNAポリメラーゼ / インフルエンザウイルス … More Except Principal Investigator 宿主因子 / 特異的体内伝播 / 血液脳関門 / 病原性 / ポリオウイルス Less

Identification of the rate limiting step in the formation of cccDNA of Hepatitis B virus for the development of a new cell culture model for studying the persistence of HBV infectionPrincipal Investigator
- Principal Investigator
  
  山崎学
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Microbial Chemistry Research Foundation
Drug discovery through identification of microbial products against SARS-CoV-2 proteasesPrincipal Investigator
- Principal Investigator
  
  山崎学
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Microbial Chemistry Research Foundation
Search for new potential drug targets for Hepatitis B virus genome replication based on chemical biologyPrincipal Investigator
- Principal Investigator
  
  YAMASAKI Manabu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Microbial Chemistry Research Foundation
Identification of a novel inhibitor of influenza virus polymerase based on inhibition of conformational change required for cap-dependent endonuclease activityPrincipal Investigator
- Principal Investigator
  
  YAMASAKI Manabu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Microbial Chemistry Research Foundation
Analysis of poliovirus permeation mechanism through blood brain barier
- Principal Investigator
  
  NOMOTO Akio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Microbial Chemistry Research Foundation

All 2017 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit2017
- Author(s)
  Suzuki M, Kondo S, Yamasaki M, Matsuda N, Nomoto A, Suzuki T, Saito I, Kanegae Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 41851-41851
- DOI
  10.1038/srep41851
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J05883, KAKENHI-PROJECT-15K08507
[Journal Article] Current landscape and future prospects of antiviral drugs derived from microbial products2017
- Author(s)
  Takizawa Naoki、Yamasaki Manabu
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 71 Issue: 1 Pages: 45-52
- DOI
  10.1038/ja.2017.115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08507
[Journal Article] The essential role for the RNA triphosphatase Cetlp in nuclear import of the mRNA capping enzyme Cetlp-Ceglp complex of Saccharomyces cerevisiae2013
- Author(s)
  Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Ayako Saito, Akira Fukao, Akio Nomoto, Kiyobisa Mizumoto
- Journal Title
  
  ProsOne
  
  Volume: 8(10) Issue: 10 Pages: e78000-e78000
- DOI
  10.1371/journal.pone.0078000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02416, KAKENHI-PROJECT-23390113, KAKENHI-PUBLICLY-24115715, KAKENHI-PROJECT-24659139, KAKENHI-PROJECT-25291007, KAKENHI-PROJECT-25670151, KAKENHI-PROJECT-25871077
[Presentation] 新規RNA 5'-トリホスファターゼ阻害物質MI481-42F6 A, B, CおよびDに関する研究2014
- Author(s)
  梅北まや、五十嵐雅之、澤竜一、山崎学、林千草、波多野和樹、藤原俊伸、水本清久、野本明男
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス(川崎市)
- Year and Date
  2014-03-30
- Data Source
  KAKENHI-PROJECT-24659139
[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索2013
- Author(s)
  山崎学、滝沢直己、藤原俊伸、水本清久、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-24659139
[Presentation] インフルエンザウイルスRNA ポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索2013
- Author(s)
  山崎学, 滝沢直己, 藤原俊伸, 水本清久, 野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] The essential role for RNA triphosphatase Cet1p in nuclear import of capping enzyme complex in Saccharomyces cervisiae2012
- Author(s)
  Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Kiyohisa Mizumoto, and Akio Nomoto
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] The essential role for RNA triphosphatase Cet1p in transport of capping enzyme in Saccharomyces cerevisiae2012
- Author(s)
  Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Kiyohisa Mizumoto, and Akio Nomoto
- Organizer
  The 22nd CDB Meeting : RNA Sciences in Cell and Developmental Biology II
- Place of Presentation
  理研 CDB (神戸市)
- Year and Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] Characterization of a receptor for poliovirus BBB-permeation2011
- Author(s)
  Coh-ichi Nihei, Manabu Yamasaki, and Akio Nomoto
- Organizer
  International Union of Microbiological Societies 2011 Congress (IUMS)
- Place of Presentation
  札幌コンベンションセンター(札幌市)
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] The essential role for RNA triphosphatase Cet1p in transport of capping enzyme in Saccharomyces cerevisiae
- Author(s)
  Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Kiyohisa Mizumoto, Akio Nomoto
- Organizer
  The 22nd CDB Meeting: RNA Sciences in Cell and Developmental Biology II
- Place of Presentation
  理研CDB (神戸)
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] ポリオウイルスの血液脳関門透過機構の解析
- Author(s)
  水谷壮利、二瓶浩一、山崎学、石坂彩、野本明男
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  グランキューブ大阪 (大阪)
- Data Source
  KAKENHI-PROJECT-23390113
[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索
- Author(s)
  山崎学、滝沢直己、藤原俊伸、水本清久、野本明男
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-24659139
[Presentation] 新規RNA5’-トリホスファターゼ阻害物質MI481-42F6 A,B,CおよびDに関する研究
- Author(s)
  梅北まや、五十嵐雅之、澤竜一、山崎学、林千草、波多野和樹、藤原俊伸、水本清久、野本明男
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス（川崎市）
- Data Source
  KAKENHI-PROJECT-24659139

1. NOMOTO Akio (70112670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. ARAKAWA Masayuki (90398868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKIZAWA Naoki (50448502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. MIZUMOTO Kiyohisa (80092344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. SAITO Izumu (70158913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KANEGAE Yumi (80251453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KONDO Saki (80451871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IGARASHI Masayuki (40260137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAWA Ryuichi (50235454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamasaki Manabu 山崎 学

山崎 学 ヤマサキ マナブ

YAMASAKI Manabu 山崎 学

Research Projects

Research Products

Co-Researchers

Identification of the rate limiting step in the formation of cccDNA of Hepatitis B virus for the development of a new cell culture model for studying the persistence of HBV infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery through identification of microbial products against SARS-CoV-2 proteasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for new potential drug targets for Hepatitis B virus genome replication based on chemical biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a novel inhibitor of influenza virus polymerase based on inhibition of conformational change required for cap-dependent endonuclease activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of poliovirus permeation mechanism through blood brain barier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current landscape and future prospects of antiviral drugs derived from microbial products2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The essential role for the RNA triphosphatase Cetlp in nuclear import of the mRNA capping enzyme Cetlp-Ceglp complex of Saccharomyces cerevisiae2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規RNA 5'-トリホスファターゼ阻害物質MI481-42F6 A, B, CおよびDに関する研究2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] インフルエンザウイルスRNAポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] インフルエンザウイルスRNA ポリメラーゼがもつキャップ依存エンドヌクレアーゼ活性を阻害する低分子化合物の探索2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The essential role for RNA triphosphatase Cet1p in nuclear import of capping enzyme complex in Saccharomyces cervisiae2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The essential role for RNA triphosphatase Cet1p in transport of capping enzyme in Saccharomyces cerevisiae2012

Author(s)

Organizer

Place of Presentation

Year and Date

Yamasaki Manabu 山崎学

山崎学ヤマサキマナブ

YAMASAKI Manabu 山崎学