KODAMA Yukinobu 兒玉幸修

Researcher Number	50448510
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 病院(医学系), 准教授
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 病院(医学系), 准教授 2017 – 2022: 長崎大学, 病院(医学系), 准教授 2014 – 2017: 長崎大学, 医歯薬学総合研究科(薬学系), 助教 2011 – 2013: 長崎大学, 医歯(薬)学総合研究科, 助教 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教 2007 – 2008: 長崎大学, 医学部・歯学部附属病院, 教務職員
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Physical pharmacy / Surgical dentistry
Keywords	Principal Investigator 遺伝子デリバリー / 核酸医薬 / ドラッグデリバリー / 遺伝子・核酸医薬 / siRNA / コンドロイチン硫酸 / DNAワクチン / 肺がん / メラノーマ / ナノ微粒子 … More / 経肺投与 / 薬学 / 核酸 / 肺指向性 / ナノ粒子 / 肺線維症 / 硫酸プロタミン / 医薬品 / メトトレキサート / メトトレキセート / 関節リウマチ … More Except Principal Investigator 遺伝子 / 自己組織化デバイス / 基質 / 遺伝子送達デバイス / 遺伝子導入担体 / 遺伝子活性化基質 / 遺伝子治療 / 人工骨基質 / ベクター / 骨再生 / chondroitin sulfate / γ-polyglutamic acid / アニオン性高分子 / 遺伝子導入 / ナノ微粒子 / カチオン性遺伝子ベクター / 低分子リガンド / 静電的相互作用 / 遺伝子導入技術 / 自己組織化 / 生体分解型ベクター / 生体適合型ベクター / Drug delivery system / グリチルリチン / 葉酸 / 遺伝子デリバリー / ナノ材料 / 癌 / ドラッグデリバリー / 担癌動物 / 肝血流 / 薬物速度論 / 肝臓表面 / 薬物動態 / ドラッグデリバリーシステム / 製剤学 Less

がん指向性と腹腔内滞留性を併せもつ新規ナノ微粒子製剤の開発と腹膜播種治療への展開Principal Investigator
- Principal Investigator
  
  兒玉幸修
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
Development of gene and nucleic acid medicines for lung cancer based on the multifunctional pulmonary nanoparticlesPrincipal Investigator
- Principal Investigator
  
  Kodama Yukinobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
Development of pulmonary fibrosis drug based on lung-targeting and long-acting nano-DDSPrincipal Investigator
- Principal Investigator
  
  KODAMA Yukinobu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
Gene activated-matrix comprised of self-assemble and multi-functional nano-devise facilitates the bone engineering
- Principal Investigator
  
  Asahina Izumi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagasaki University
Development of novel gene medicines based on the multifunctional nano-device using the regulatory-approved medical productsPrincipal Investigator
- Principal Investigator
  
  KODAMA Yukinobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
Development of novel gene medicine for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  KODAMA Yukinobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
The development of self-assembly nano-devices based on electrostatic interaction and the application to selective drug delivery
- Principal Investigator
  
  SASAKI Hitoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagasaki University
Development of formulation for liver surface application to control distribution and period of anticancer drugs and gene medicines
- Principal Investigator
  
  NISHIDA Koyo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagasaki University

[Journal Article] Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation2021
- Author(s)
  Masahito Hara,Yoshinori Sumita,Yukinobu Kodama,Mayumi Iwatake, Hideyuki Yamamoto,Rena Shido,Shun Narahara,Takunori Ogaeri,Hitoshi Sasaki and Izumi Asahina
- Journal Title
  
  Materials
  
  Volume: 14 Issue: 22 Pages: 22-22
- DOI
  10.3390/ma14227097
- NAID
  120007186847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K23059, KAKENHI-PROJECT-17H01604, KAKENHI-PROJECT-20K10010
[Journal Article] Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis2021
- Author(s)
  Kurosaki T, Kanda H, Hashizume J, Sato K, Harasawa H, Nakamura T, Sasaki H, Kodama Y.
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 11 Pages: 1983-1983
- DOI
  10.3390/pharmaceutics13111983
- NAID
  120007188604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07156, KAKENHI-PROJECT-20K12649
[Journal Article] Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle2021
- Author(s)
  Kurosaki T, Katafuchi Y, Hashizume J, Harasawa H, Nakagawa H, Nakashima M, Nakamura T, Yamashita C, Sasaki H, Kodama Y.
- Journal Title
  
  Drug Delivery
  
  Volume: 28 Issue: 1 Pages: 1585-1593
- DOI
  10.1080/10717544.2021.1955040
- NAID
  120007172271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07156, KAKENHI-PROJECT-23K21856
[Journal Article] Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation2021
- Author(s)
  Shido Rena、Sumita Yoshinori、Hara Masahito、Iwatake Mayumi、Narahara Shun、Umebayashi Mayumi、Miura Kei-ichiro、Kodama Yukinobu、Asahina Izumi
- Journal Title
  
  Regenerative Biomaterials
  
  Volume: 8 Issue: 2 Pages: 1-9
- DOI
  10.1093/rb/rbaa060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10010, KAKENHI-PROJECT-17H01604
[Journal Article] Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery2021
- Author(s)
  Hamada E, Kurosaki T, Hashizume J, Harasawa H, Nakagawa H, Nakamura T, Kodama Y, Sasaki H.
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 1 Pages: 126-126
- DOI
  10.3390/pharmaceutics13010126
- NAID
  120006961264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07156, KAKENHI-PROJECT-18H02589
[Journal Article] Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice2021
- Author(s)
  Kodama Y, Tokunaga A, Hashizume J, Nakagawa H, Harasawa H, Kurosaki T, Nakamura T, Nishida K, Nakashima M, Hashida M, Kawakami S, Sasaki H.
- Journal Title
  
  Drug Delivery
  
  Volume: 28 Issue: 1 Pages: 542-549
- DOI
  10.1080/10717544.2021.1895904
- NAID
  120007150301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07156
[Journal Article] Development of a DNA Vaccine for Melanoma Metastasis by Inhalation Based on an Analysis of Transgene Expression Characteristics of Naked pDNA and a Ternary Complex in Mouse Lung Tissues2020
- Author(s)
  Kodama Y, Nakashima M, Nagahara T, Oyama N, Hashizume J, Nakagawa H, Harasawa H, Muro T, Kurosaki T, Yamashita C, Hashida M, Kitahara T, Sasaki H, Kawakami S, Nakamura T
- Journal Title
  
  Pharmaceutics
  
  Volume: 12 Issue: 6 Pages: 540-540
- DOI
  10.3390/pharmaceutics12060540
- NAID
  120006988149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07156, KAKENHI-PROJECT-18H02589
[Journal Article] Methotrexate-Coated Complexes of Plasmid DNA and Polyethylenimine for Gene Delivery2018
- Author(s)
  Kodama Y, Nishigaki W, Nakamura T, Fumoto S, Nishida K, Kurosaki T, Nakagawa H, Kitahara T, Muro T, Sasaki H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 10 Pages: 1537-1542
- DOI
  10.1248/bpb.b18-00144
- NAID
  130007494219
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-10-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08449, KAKENHI-PROJECT-18H02589
[Journal Article] Gene delivery system of pDNA using the blood glycoprotein fetuin.2018
- Author(s)
  Kodama Y, Hanamura H, Muro T, Nakagawa H, Kurosaki T, Nakamura T, Kitahara T, Kawakami S, Nakashima M, Sasaki H.
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 印刷中 Issue: 7 Pages: 604-609
- DOI
  10.1080/1061186x.2017.1405425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08449, KAKENHI-PROJECT-18H02589
[Journal Article] Application of biodegradable dendrigraft poly-l-lysine to a small interfering RNA delivery system.2017
- Author(s)
  Kodama Y, Kuramoto H, Mieda Y, Muro T, Nakagawa H, Kurosaki T, Sakaguchi M, Nakamura T, Kitahara T, Sasaki H.
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 25 Issue: 1 Pages: 49-57
- DOI
  10.1080/1061186x.2016.1184670
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293034, KAKENHI-PROJECT-26860107, KAKENHI-PROJECT-15K08444
[Journal Article] Development of a Multi-functional Nano-device for Safe and Effective Gene Delivery to Target Organs.2016
- Author(s)
  Kodama Y.
- Journal Title
  
  Yakugaku Zasshi.
  
  Volume: 136 Pages: 1533-1539
- NAID
  130005267661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860107
[Journal Article] Secure and effective gene delivery system of plasmid DNA coated by polynucleotide.2015
- Author(s)
  Kodama Y, Ohkubo C, Kurosaki T, Egashira K, Sato K, Fumoto S, Nishida K, Higuchi N, Kitahara T, Nakamura T, Sasaki H.
- Journal Title
  
  J Drug Target.
  
  Volume: 23 Issue: 1 Pages: 43-51
- DOI
  10.3109/1061186x.2014.950665
- NAID
  120006986293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590198, KAKENHI-PROJECT-25350553, KAKENHI-PROJECT-26293034, KAKENHI-PROJECT-26860107
[Journal Article] Immunogenicity and anti-fecundity effect of nanoparticle coated glutathione S-transferase (SjGST) DNA vaccine against murine Schistosoma japonicum infection.2015
- Author(s)
  Mbanefo EC, Kumagai T, Kodama Y, Kurosaki T, Furushima-Shimogawara R, Cherif MS, Mizukami S, Kikuchi M, Huy NT, Ohta N, Sasaki H, Hirayama K.
- Journal Title
  
  Parasitol Int.
  
  Volume: 64 Issue: 4 Pages: 24-31
- DOI
  10.1016/j.parint.2015.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590503, KAKENHI-PROJECT-26293034, KAKENHI-PROJECT-26860107, KAKENHI-PROJECT-15K08445, KAKENHI-PROJECT-15H05278, KAKENHI-PROJECT-26670198, KAKENHI-PROJECT-25293099
[Journal Article] Quaternary complexes modified from pDNA and poly-l-lysine complexes to enhance pH-buffering effect and suppress cytotoxicity.2015
- Author(s)
  Kodama Y, Yatsugi Y, Kitahara T, Kurosaki T, Egashira K, Nakashima M, Muro T, Nakagawa H, Higuchi N, Nakamura T, Sasaki H.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 104 Issue: 4 Pages: 1470-1477
- DOI
  10.1002/jps.24364
- NAID
  120006987163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860107, KAKENHI-PROJECT-26293034
[Journal Article] Splenic Gene Delivery System Using Self-assembling Nano-complex with Phosphatidylserine Analog.2015
- Author(s)
  Kurosaki T, Nakasone C, Kodama Y, Egashira K, Harasawa H, Muro T, Nakagawa H, Kitahara T, Higuchi N, Nakamura T, Sasaki H.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 38 Pages: 23-29
- NAID
  130004872233
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860107
[Journal Article] Novel siRNA delivery system using a ternary polymer complex with strong silencing effect and no cytotoxicity.2014
- Author(s)
  Kodama Y, Shiokawa Y, Nakamura T, Kurosaki T, Aki K, Nakagawa H, Muro T, Kitahara T, Higuchi N, Sasaki H.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 37 Pages: 1274-1281
- NAID
  130004677533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860107
[Journal Article] Biodegradable nanoparticles composed of dendrigraft poly-L-lysine for gene delivery.2014
- Author(s)
  Kodama Y, Nakamura T, Kurosaki T, Egashira K, Mine T, Nakagawa H, Muro T, Kitahara T, Higuchi N, Sasaki H.
- Journal Title
  
  Eur J Pharm Biopharm.
  
  Volume: 87 Issue: 3 Pages: 472-479
- DOI
  10.1016/j.ejpb.2014.04.013
- NAID
  120006986334
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590198, KAKENHI-PROJECT-26293034, KAKENHI-PROJECT-26860107
[Journal Article] Secure splenic delivery of plasmid DNA and its application to DNA vaccine2013
- Author(s)
  Kurosaki T, Kodama Y, Muro T, Higuchi N, Nakamura T, Kitahara T, Miyakoda M, Yui K, Sasaki H
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36(11) Pages: 1800-6
- NAID
  130003382044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Ternary complex of plasmid DNA with protamine andγ-polyglutamic acid for biocompatible gene delivery system2013
- Author(s)
  Kanda K, Kodama Y, Kurosaki T, Imamura M, Nakagawa H, Muro T, Higuchi N, Nakamura T, Kitahara T, Honda M, Sasaki H
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36(11) Pages: 1794-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Safe and Effective Delivery of Small Interfering RNA with Polymer- and Liposomes-Based Complexes2013
- Author(s)
  Yukinobu Kodama, Satoe Harauchi, Saki Kawanabe, Nobuhiro Ichikawa, Hiroo Nakagawa, Takahiro Muro, Norihide Higuchi, Tadahiro Nakamura, Takashi Kitahara, Hitoshi Sasaki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Pages: 995-1001
- NAID
  130003361445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Safe and effective delivery of small interfering RNA with polymer- and liposomes-based complexes2013
- Author(s)
  Kodama Y, Harauchi S, Kawanabe S, Ichikawa N, Nakagawa H, Muro T, Higuchi N, Nakamura T, Kitahara T, Sasaki H
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 36(6) Pages: 995-1001
- NAID
  130003361445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Development of effective cancer vaccine using targeting system of antigen protein to APCs2012
- Author(s)
  Kurosaki T, Kitahara T, Nakamura T, Nishida K, Fumoto S, Kodama Y, Nakagawa H, Higuchi N, Sasaki H
- Journal Title
  
  Pharm Res
  
  Volume: 29(2) Pages: 483-9
- NAID
  120006985292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer2011
- Author(s)
  Kurosaki T, Yamashita Y, Aki K, Harasawa H, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Kitahara T, Sasaki H
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(11) Pages: 4855-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Nanoparticles electrostatically coated with folic acid for effective gene therapy2011
- Author(s)
  Kurosaki T, Morishita T, Kodama Y, Sato K, Nakagawa H, Higuchi N, Nakamura T, Hamamoto T, Sasaki H, Kitahara T
- Journal Title
  
  Mol Pharm
  
  Volume: 8(3) Pages: 913-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790186
[Journal Article] Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer2011
- Author(s)
  Kurosaki T, Yamashita Y, Aki K, Harasawa H, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Kitahara T, Sasaki H
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(11) Pages: 4855-4863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Nanoparticles electrostatically coated with folic acid for effective gene therapy2011
- Author(s)
  Kurosaki T, Morishita T, Kodama Y, Sato K, Nakagawa H, Higuchi N, Nakamura T, Hamamoto T, Sasaki H, Kitahara T
- Journal Title
  
  Mol Pharm
  
  Volume: 8(3) Pages: 913-919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Secure and effective gene vector of polyamidoamine dendrimer pharraac eutically modified with anionic polymer2011
- Author(s)
  Kurosaki T, Yamashita Y, Aki K, Harasawa H, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Kitahara T, Sasaki H
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Issue: 11 Pages: 4855-4863
- DOI
  10.1002/jps.22701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy2010
- Author(s)
  Kurosaki T, Kitahara T, Kawakami S, Higuchi Y, Yamaguchi A, Nakagawa H, Kodama Y, Hamamoto T, Hashida M, Sasaki H
- Journal Title
  
  J Control Release
  
  Volume: 142(3) Pages: 404-410
- NAID
  120006984597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy.2010
- Author(s)
  Kurosaki T, Kitahara T, Kawakami S, Higuchi Y, Yamaguchi A, Nakagawa H, Kodama Y, Hamamoto T, Hashida M, Sasaki H.
- Journal Title
  
  J Control Release.
  
  Volume: 142 Pages: 404-410
- NAID
  120006984597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Chondroitin sulfate capsule system for efficient and secure gene delivery2010
- Author(s)
  Kurosaki T, Kitahara T, Fumoto S, Nishida K, Yamamoto K, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Sasaki H
- Journal Title
  
  J Pharm Pharm Sci
  
  Volume: 13(3) Pages: 351-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Chondroitin sulfate capsule system for efficient and secure gene delivery.2010
- Author(s)
  Kurosaki T, Kitahara T, Fumoto S, Nishida K, Yamamoto K, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Sasaki H.
- Journal Title
  
  J Pharm Pharm Sci
  
  Volume: 13 Pages: 351-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Pulmonary gene delivery of hybrid vector, lipopolyplex containing N-lauroylsarcosine, via the systemic route2009
- Author(s)
  Kurosaki T, Kishikawa R, Matsumoto M, Kodama Y, Hamamoto T, To H, Niidome T, Takayama K, Kitahara T, Sasaki H
- Journal Title
  
  J Control Release
  
  Volume: 136(3) Pages: 213-219
- NAID
  120006984134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Ternary complexes of pDNA, polyethylenimine, and gamma-polyglutamic acid for gene delivery systems.2009
- Author(s)
  Kurosaki, T., Kitahara, T., Fumoto, S., Nishida, K., Nakamura, J., Niidome, T., Kodama, Y., Nakagawa, H., To, H., Sasaki, H.
- Journal Title
  
  Biomaterials 30
  
  Pages: 2846-2853
- NAID
  120006982935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] The development of a gene vector electrostatically assembled with a polysaccharide capsule.2009
- Author(s)
  Kurosaki, T, Kitahara, T., Kawakami, S., Nishida, K., Nakamura, J., Teshima, M., Nakagawa, H., Kodama, Y., To, H., Sasaki, H.
- Journal Title
  
  Biomaterials 30
  
  Pages: 4427-4434
- NAID
  120006984133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Ternary complexes of pDNA, polyethylenimine, and gamma-polyglutamic acid for gene delivery systems2009
- Author(s)
  Kurosaki T, Kitahara T, Fumoto S, Nishida K, Nakamura J, Niidome T, Kodama Y, Nakagawa H, To H, Sasaki H
- Journal Title
  
  Biomaterials
  
  Volume: 30(14) Pages: 2846-2853
- NAID
  120006982935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Pulmonary gene delivery of hybrid vector, lipopolyplex containing N-lauroylsarcosine, via the systemic route.2009
- Author(s)
  Kurosaki, T., Kishikawa, R., Matsumoto, M., Kodama, Y., Hamamoto, T., To, H., Niidome, T., Takayama, K., Kitahara, T., Sasaki, H.
- Journal Title
  
  J.Control. Release 136
  
  Pages: 213-219
- NAID
  120006984134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] The development of a gene vector electrostatically assembled with a polysaccharide capsule2009
- Author(s)
  Kurosaki T, Kitahara T, Kawakami S, Nishida K, Nakamura J, Teshima M, Nakagawa H, Kodama Y, To H, Sasaki H
- Journal Title
  
  Biomaterials
  
  Volume: 30(26) Pages: 4427-4434
- NAID
  120006984133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390010
[Journal Article] Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects2008
- Author(s)
  Y. Kodama, S. Fumoto, J. Nishi, M. Nakashima, H. Sasaki, J. Nakamura, K. Nishida
- Journal Title
  
  Biological & Pharmaceutical Bulletin 31
  
  Pages: 1049-1052
- NAID
  110006663980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590042
[Journal Article] Absorption and distribution characteristics of 5-fluorouracil (5-FU) after an application to the liver surface in rats in order to reduce systemic side effects2008
- Author(s)
  Yukinobu Kodama
- Journal Title
  
  Biological & Pharmaceutical Bulletin 31
  
  Pages: 1049-1052
- NAID
  110006663980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590042
[Patent] 肺指向性薬物送達体2019
- Inventor(s)
  佐々木均、兒玉幸修、川上茂
- Industrial Property Rights Holder
  佐々木均、兒玉幸修、川上茂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-098677
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] 多機能型生体適合性ナノ微粒子を基盤とした遺伝子・核酸医薬の開発と経肺投与への展開2021
- Author(s)
  兒玉幸修、黑﨑友亮、佐々木均
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07156
[Presentation] 抗原提示細胞へ標的可能な DDS製剤を基盤とした核酸ワクチンの開発と臨床応用2020
- Author(s)
  兒玉幸修、黑﨑友亮、佐々木均
- Organizer
  第90回日本感染症学会西日本地方会学術集会・第63回日本感染症学会中日本地方会学術集会・第68回日本化学療法学会西日本支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07156
[Presentation] RNAワクチン開発を目的としたmRNA内包三元複合体の開発2020
- Author(s)
  濵田英里、黑﨑友亮、兒玉幸修、室高広、中村忠博、佐々木均
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K07156
[Presentation] 臨床薬学的視点により設計した多機能型DDS製剤を基盤とする核酸・遺伝子医薬の創出2020
- Author(s)
  兒玉幸修、佐々木均
- Organizer
  第30回日本医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07156
[Presentation] Effective gene-activated matrix with self-assembly nano-devices for bone engineering.2019
- Author(s)
  Hara M, Sumita Y, Shido R, Kodama Y, Asahina I
- Organizer
  International Association for Dental Research (IADR) 97th General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01604
[Presentation] 生体適合性素材の自己組織化による標的化DDS製剤の開発2019
- Author(s)
  兒玉幸修
- Organizer
  日本薬剤学会第34年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] 静電的相互作用を基盤としたaptamer被膜型遺伝子ベクターの開発2019
- Author(s)
  黒崎友亮、兒玉幸修、中川博雄、中村忠博、大山要、中嶋幹郎、川上茂、佐々木均
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] 大腸がん腹膜播種に対するVEGF-siRNAナノ粒子の開発2018
- Author(s)
  大倉真生, 兒玉幸修, 北原隆志, 佐々木均
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] 生体分解型siRNAベクターの構築と有用性評価2018
- Author(s)
  柿木優希, 佐々木均, 北原隆志, 兒玉幸修
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] 大腸がん腹膜播種に対するMDM2-siRNA複合体の有効性評価2018
- Author(s)
  丸田由佳理, 兒玉幸修, 北原隆志, 佐々木均
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] VEGF-siRNA複合体によるメラノーマ肺転移の抑制2018
- Author(s)
  岡田明莉, 兒玉幸修, 加藤由佳, 北原隆志, 佐々木均
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] c-Myc-siRNA三重複合体によるメラノーマ増殖抑制に関する基礎的検討2018
- Author(s)
  三枝由香莉, 兒玉幸修, 北原隆志, 佐々木均
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] メラノーマに対する生体分解型VEGF-siRNA複合体の有用性評価2017
- Author(s)
  加藤由佳、兒玉幸修、上田由貴、北原隆志、佐々木均
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-17K08449
[Presentation] ポリアミノ酸で構築した生体分解型マラリアナノワクチンの開発2016
- Author(s)
  根岸智奈美、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] グリコサミノグリカンで被膜した生体分解型遺伝子ベクターの開発2016
- Author(s)
  三枝由香莉、兒玉幸修、岩永真理恵、北原隆志、佐々木均
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] 関節リウマチ治療を目的としたメトトレキサートを構成成分とする遺伝子ベクターの開発2016
- Author(s)
  小林瑞希、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] 抗原提示細胞標的化ナノ粒子を用いた新規がんワクチンの開発2015
- Author(s)
  花村啓紀、兒玉幸修、北原隆志、中嶋幹郎、佐々木均
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] Dendrigraft poly-L-lysine を基材とした遺伝子ベクターの有用性評価2015
- Author(s)
  徳永彩子、兒玉幸修、樋口則英、北原隆志、佐々木均
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] 標的臓器への安全かつ高効率な核酸医薬送達を実現する多機能性ナノデバイスの開発2015
- Author(s)
  兒玉幸修
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  九州保健福祉大学（宮崎県延岡市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] pH緩衝能の増大と毒性軽減を目的とした四重複合体の開発と有用性評価2015
- Author(s)
  上田由貴、兒玉幸修、三枝由香莉、北原隆志、佐々木均
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] アニオン性三重複合体の眼疾患用遺伝子ベクターとしての有用性評価2015
- Author(s)
  永原忠幸、兒玉幸修、北原隆志、中嶋幹郎、佐々木均
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] 生体分解型DNAナノワクチンによる悪性黒色腫の増殖抑制2015
- Author(s)
  徳永彩子、兒玉幸修、北原隆志、佐々木均
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] アニオン性デンドリプレックスを用いた遺伝子デリバリーシステムの開発2015
- Author(s)
  野田稜、兒玉幸修、黑﨑友亮、中村忠博、北原隆志、佐々木均
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] Dendrigraft poly-L-lysineを用いた生体内分解型遺伝子ベクターの開発2013
- Author(s)
  塩川裕美、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] ポリヌクレオチド被膜型複合体による脾臓指向性新規遺伝子ベクターの開発2013
- Author(s)
  矢次結衣子、兒玉幸修、大久保智佳子、北原隆志、佐々木均
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] Fetuin被膜型複合体による新規遺伝子ベクターの構築2013
- Author(s)
  兒玉幸修、北原隆志、江頭かの子、中嶋幹郎、樋口則英、中村忠博、佐々木均
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] 樹状細胞標的型ナノデバイスを用いたマラリアDNAナノワクチンの開発2013
- Author(s)
  西垣和香、兒玉幸修、北原隆志、佐々木均
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  佐世保
- Year and Date
  2013-12-08
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] 肝細胞選択的なグリチルリチン含有遺伝子ベクターの開発2012
- Author(s)
  原内智慧、川鍋早紀、黒崎友亮、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] ホスファチジルセリンアナログを用いた脾臓指向性遺伝子導入ベクターの開発2012
- Author(s)
  大久保智佳子、仲宗根ちひろ、黒崎友亮、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] 制癌剤と遺伝子同時送達を目的としたメトトレキサート被膜型遺伝子ベクターの開発2012
- Author(s)
  兒玉幸修
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] 制癌剤と遺伝子同時送達を目的としたメトトレキサート被膜型遺伝子ベクターの開発2012
- Author(s)
  兒玉幸修、黒崎友亮、江頭かの子、中嶋幹郎、中川博雄、樋口則英、中村忠博、北原隆志、佐々木均
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] 静電的自己組織化を基盤としたアニオン性siRNAベクターの開発2012
- Author(s)
  塩川裕美、兒玉幸修、原内智慧、北原隆志、佐々木均
- Organizer
  第29回日本薬学会九州支部大会
- Place of Presentation
  熊本
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] Polyplex of pDNA with poly-L-lysine, poly-L-histidine, andγ-polyglutamic acid for biocompatible gene delivery system2011
- Author(s)
  Yukinobu Kodama, Tomoaki Kurosaki, Kanoko Egashira, Tadahiro Nakamura, Takashi Kitahara, Hitoshi Sasaki
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23790186
[Presentation] グリチルリチン被膜型肝指向性遺伝子ベクターの開発2011
- Author(s)
  川鍋早紀、黒崎友亮、兒玉幸修、北原隆志、佐々木均
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] 三重複合体による新規遺伝子ベクターの開発:コンドロイチン硫酸被膜型デンドリプレックス2011
- Author(s)
  今村政信、黒崎友亮、兒玉幸修、北原隆志、佐々木均
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] Dendrimerを用いた三次元型遺伝子ベクターの開発2010
- Author(s)
  山下祐未、黒崎友亮、森下圭美、兒玉幸修、北原隆志、佐々木均
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] γ-Polyglutamic acid被膜型遺伝子ベクターの開発2010
- Author(s)
  黒崎友亮、北原隆志、兒玉幸修、藤秀人、濱本知之、佐々木均
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] 脾臓標的化遺伝子ベクターの開発とDNAワクチンベクターへの応用2010
- Author(s)
  黒崎友亮、北原隆志、兒玉幸修、西田孝洋、麓伸太郎、佐々木均
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] Dendrimerを用いた三元型遺伝子ベクターの開発2010
- Author(s)
  山下祐未、黒崎友亮、森下圭美、兒玉幸修、北原隆志、佐々木均
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] COMPLEX OF PLASMID DNA WITH N-LAUROYLSARCOSINE LIPOSOMES THROUGH CALCIUM BRIDGIHG FOR EFFECTIVE AND SECURE GENE DELIVERY2009
- Author(s)
  Masato Nakai, Tomoaki Kurosaki, Yukinobu Kodama, Takashi Kitahara, Hitoshi Sasaki
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  福岡
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21390010
[Presentation] 肝臓表面投与後の5-FUの肝内分布に及ぼす血流や癌の影響2008
- Author(s)
  西田孝洋, 兒玉幸修, 近藤理美, 西村知沙, 麓伸太郎, 中嶋幹郎, 佐々木均, 中村純三
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590042
[Presentation] Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer
- Author(s)
  Yukinobu Kodama, Yumi Yamashita, Takashi Kitahara, Sasaki Hitoshi
- Organizer
  5th Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne Convention and Exhibition Centre（メルボルン）
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] Nanoparticles electrostatically coated with folic acid for effective and safe gene delivery
- Author(s)
  Hitoshi Sasaki, Yukinobu Kodama, Tamami Morishita, Takashi Kitahara
- Organizer
  5th Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne Convention and Exhibition Centre（メルボルン）
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] Dendrigraft poly-L-lysineを構成成分とした生分解型siRNAベクターの構築
- Author(s)
  藏本悠、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮ソニックシティビル（大宮）
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26860107
[Presentation] 医療用医薬品を用いたGMP基準の新規遺伝子ベクターの開発
- Author(s)
  西垣和香、兒玉幸修、北原隆志、佐々木均
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮ソニックシティビル（大宮）
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26860107

1. SASAKI Hitoshi (00170689)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
2. KAWAKAMI Shigeru (20322307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. NISHIDA Koyo (20237704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. FUMOTO Shintaro (70380988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TO Hideto (90346809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
6. KUROSAKI Tomoaki (00582016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 26 results
7. KITAHARA Takashi (30380934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
8. Asahina Izumi (30221039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小守壽文 (00252677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 住田吉慶 (50456654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 鎌倉慎治 (80224640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三浦桂一郎 (10634446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KUMAGAI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 原昌士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 岩竹真弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 太田伸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KODAMA Yukinobu 兒玉 幸修

Research Projects

Research Products

Co-Researchers

がん指向性と腹腔内滞留性を併せもつ新規ナノ微粒子製剤の開発と腹膜播種治療への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene and nucleic acid medicines for lung cancer based on the multifunctional pulmonary nanoparticlesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Development of pulmonary fibrosis drug based on lung-targeting and long-acting nano-DDSPrincipal Investigator

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Gene activated-matrix comprised of self-assemble and multi-functional nano-devise facilitates the bone engineering

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Development of novel gene medicines based on the multifunctional nano-device using the regulatory-approved medical productsPrincipal Investigator

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Development of novel gene medicine for rheumatoid arthritisPrincipal Investigator

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The development of self-assembly nano-devices based on electrostatic interaction and the application to selective drug delivery

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Development of formulation for liver surface application to control distribution and period of anticancer drugs and gene medicines

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[Journal Article] Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation2021

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[Journal Article] Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis2021

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[Journal Article] Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle2021

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[Journal Article] Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation2021

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[Journal Article] Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery2021

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KODAMA Yukinobu 兒玉幸修