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SAKAMOTO Yosuke  坂本 洋右

ORCIDConnect your ORCID iD *help
Researcher Number 50451745
Other IDs
Affiliation (based on the past Project Information) *help 2013 – 2023: 千葉大学, 医学部附属病院, 講師
2009 – 2012: Chiba University, 医学部附属病院, 助教
2011: 千葉大学, 医学部・附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Except Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Keywords
Principal Investigator
口腔癌 / single cell RNA sequence / heterogeneity / 薬剤耐性担当因子 / シングルセル解析 / NGS / scRNA-seq解析 / 抗癌剤耐性 / Plod2Floxedマウス / クロスリンク … More / リシン水酸化酵素 / Plod2 / コンディショナルノックアウトマウス / PLOD2 / MyoD family遺伝子 / 筋再生 / 脂肪幹細胞 / MyoD family 遺伝子 / β-catenin / Lin7C / 癌浸潤抑制法 / 癌転移抑制法 / トランスレーショナルリサーチ / HTR2C遺伝子 / Lin7C-CASK-βcateninネットワーク / 浸潤転移能 … More
Except Principal Investigator
口腔癌 / miRNA / リシン水酸化酵素2 / Collagen cross-link / Collagen Barrier / Collagen highway / 環状RNA / エクソソーム / siRNA / ファージディスプレイ法 / drug delivery system / HTR2C / ALY / GAD1 / 口腔扁平上皮癌 / Lysyl Hydroxylase 2 / ATAC-seq解析 / スーパーエンハンサー / Non-coding RNA / microRNA / ノンコーディングRNA / 人工合成環状RNA / LH2-conditional KOマウス / LH2強制発現OSCC細胞株 / コラーゲン・ハイウェイ / リシン水酸化酵素2 / ゲノムワイド機能欠損型スクリーニング法 / CRISPER sgRNAライブラリー / 放射線耐性 / CRISPR スクリーニング法 / CRISPRscreening / CRISPR / CRISPR/Cas9 / NGS / 次世代シーケンシング / CircRNA Array / non coding RNA / circRNA miRNA / circRNA Array / circRNA / non codingRNA / 樹状細胞 / ファージディスプレイ / ミサイル療法 / Lin7C / catenin / カドヘリン / カドヘリン複合体 / Wnt経路 / カテニン / Cadherin / Wnt / βcatenin / KLK13 / 扁平上皮癌 / 特異的吸着能 / 超遠心法 / エキソソーム / lncRNA / 抗がん剤耐性試験 / 抗がん剤・放射線耐性 / 抗癌剤耐性試験 / 放射線耐性試験 / 腫瘍の浸潤・転移能 / 共培養 / LINC00256A / UCA1 / long non coding RNA / TRPM6 / P38MAPK / HEK293細胞 / HacaT細胞 / SB203580 / 皮膚毒性 / Flavagline / 心毒性 / 副作用 / 頭頸部癌 / セツキシマブ / 浸潤・転移 / がん遺伝子 / 発がん / 悪性黒色腫 / MMPs / HTR2C 遺伝子 / GAD1遺伝子 / ALY遺伝子 / cadherine / WNT / β-catenin / 癌転移 / 臨床腫瘍学 / CEA遺伝子family / 転移 / 浸潤 / CEA遺伝子群 / 遺伝子発現ベクター / CEA遺伝子ファミリー Less
  • Research Projects

    (16 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (14 People)
  •  Elucidation of regulatory mechanisms of cancer cell metastasis focusing on both cancer cells and cancer-associated ECM by scRNA-seq analysis

    • Principal Investigator
      宮本 勲
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of the mechanism of cancer progression in oral cancer by tumor-promoting cyclic RNAs

    • Principal Investigator
      大和地 正信
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of Collagen Barrier and Development of Controlling Agents by Anticancer Drug Resistance Super Enhancer

    • Principal Investigator
      齋藤 智昭
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Heterogeneityに着目した口腔癌抗癌剤耐性機構の解明と制御薬の開発Principal Investigator

    • Principal Investigator
      坂本 洋右
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  CRISPR/Cas9ノックアウトスクリーニングによる放射線耐性メカニズムの同定

    • Principal Investigator
      伊豫田 学
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Mechanism of PLOD2 function in cancer invasion and metastasis of jawbone.Principal Investigator

    • Principal Investigator
      Sakamoto Yosuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of the role of non-coding RNA adsorbed cyclic RNA in cancer growth invasion and metastasis.

    • Principal Investigator
      Kasamatsu Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Development of cancer metastasis inhibitor by controlling cadherin complex and Wnt pathway via catenin

    • Principal Investigator
      Tanzawa Hideki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of siRNA / missile therapy using exosomes for oral cancer cells

    • Principal Investigator
      Uzawa Katsuhiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of novel therapy based on functions of long non coding RNA in the cancer and cancer-associated cells

    • Principal Investigator
      SHIIBA Masashi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of a new drug delivery system targeting the protein which cancer-specifically expresses

    • Principal Investigator
      Tanzawa Hideki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of a novel medicine for reducing side effects for cetuximab, a new therapeutic agent for head and neck cancer

    • Principal Investigator
      UZAWA KATSUHIRO
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of the inhibitor for cancer metastasis through Wnt signaling pathway by catenin-cadherin complex.

    • Principal Investigator
      Hideki Tanzawa
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Regeneration of muscle by introduction of MyoD family gene into adipose-derived stem cellsPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Yousuke
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Study on the expression status of CEA gene family in cancer and surrounding normal tissue and on the interaction between cancer and normal mesenchymal cells.

    • Principal Investigator
      KOIKE HIROFUMI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  A novel method for inhibiting cancer metastasis and invasion by regulating the Lin7C-CASK-βcatenin-network.Principal Investigator

    • Principal Investigator
      SAKAMOTO Yosuke
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University

All 2020 2010

All Presentation

  • [Presentation] 安藤壽晃癌抑制型環状RNA: 口腔癌誘発性マイクロRNAの特異的吸着効果による新規診断法の開発2020

    • Author(s)
      安藤壽晃 鵜澤一弘 笠松厚志 田中希 野淵嵩史 駒綾香 大島早智 伊豫田学 中嶋大 坂本洋右 椎葉正史
    • Organizer
      日本口腔外科学会
    • Data Source
      KAKENHI-PROJECT-19H03847
  • [Presentation] 口腔癌転移抑制候補タンパクLin-7C/VEL13/MALS-3の同定と包括的機能解析2010

    • Author(s)
      鵜澤一弘, 恩田健志, 佐久間健太郎, 大和地正信, 石上享嗣, 伏見一章, 中島大, 肥後盛洋, 笠松厚志, 坂本洋右, 椎葉正史, 武川寛樹, 横江秀隆, 柴原孝彦, 丹沢秀樹
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-21390531
  • 1.  TANZAWA Hideki (50236775)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 2.  UZAWA Katsuhiro (30302558)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 3.  伊豫田 学 (40431746)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  小河原 克訓 (20372360)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  Kasamatsu Atsushi (60375730)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  中嶋 大 (50431747)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 7.  SHIIBA Masashi (20301096)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  皆川 康之 (30639787)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  大和地 正信 (70451747)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  KOIKE HIROFUMI (10595995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  肥後 盛洋 (60724383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  小池 一幸 (10618060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  宮本 勲 (00741836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  齋藤 智昭 (40833554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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