SHIMIZU Toshiaki 清水利昭

Researcher Number	50468055
Affiliation (based on the past Project Information) *help	2015 – 2018: 鹿児島大学, 医歯学域医学系, 助教 2013 – 2014: 鹿児島大学, 大学院医歯学総合研究科, 助教 2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教 2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 助教 2011: 鹿児島大学, 医学部・歯学部・附属病院, 医員 2008 – 2010: 鹿児島大学, 医学部・歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Laboratory medicine / Pathological medical chemistry Except Principal Investigator Laboratory medicine / Neurology / Emergency medicine / Hematology
Keywords	Principal Investigator HMGB1 / metabolic syndrome / diabetes / obese / adipocyte / new adipocytokine / pro-inflammatory / innate / obesity / adiponectin … More / adipocytokine / 3T3-L1 adipocyte / インスリン抵抗性 / 代謝異常 / 炎症 / 脂質 / 糖尿病 / 栄養学 … More Except Principal Investigator VEGF-A / microRNA / エクソゾーム / 血管内皮細胞 / 血小板 / 血管新生 / eryptosis / 赤血球 / B細胞 / リンパ節 / 免疫 / erythrocyte / 単球 / 一酸化窒素 / miRNA / 糖尿病 / マイクロRNA / 肝癌 / platelet / 肝 / 鉄 / 血管内皮細胞増殖因子 / 病態検査学 / 血球貪食 / 脾臓 / lymph node / angiogenesis / VEGF / 細胞・組織 / NETosis / アポトーシス / ネクローシス / プログラム細胞死 / 白血球 / 血栓 / 生理学 / 生体分子 / シグナル伝達 / トランスレーショナルリサーチ / inflammation / thrombosis / programmed cell death / molecular clock / program cell death / apoptosis / セロトニン / prognosis / exhaust platelet / hepatocellular carcinoma / serotonin / iron metabolism / phagocytosis / programmed cell deat / 免疫寛容 / リンパ管新生 / 単核球 / TP53 / 肝細胞増殖因子 / 増殖因子 / 肝再生 / 巨核球 / 骨髄 / 組織再生 / hepatectomy / wound healing / regeneration / bone marrow / 老化 / 活性酸素 / 脾 / hepcidin / 貧血 / 鉄代謝 / 血管透過性 / mouse / high endothelial venule / nervus system / immune system / POEMS syndrome / HEV / iron / spleen / lymph / immune / B cell / LPS tolerance / 高内皮小静脈 / 神経 / 補体 / thrombomodulin / プラットフォーム分子 / ヒストン / 炎症 / トロンボモジュリン / 集中治療医学 / ショック / 感染病 / DIC / HMGB1 / 感染症 / 循環器・高血圧 Less

HMGB1による疼痛発症のメカニズム―カリクレイン・キニン系からの解析Principal Investigator
- Principal Investigator
  
  清水利昭
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kagoshima University
Analysis for pro grammed cell death of anuclear platelets and erythrocytes for application of laboratory medicine
- Principal Investigator
  
  Hashiguchi Teruto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Construction of the system of
- Principal Investigator
  
  Yamakuchi Munekazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Fine tuning the immune response through physiological hemophagocytosis
- Principal Investigator
  
  Hashiguchi Teruto
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
The role of Endothelial miRNA in the regulation of vascular integrity
- Principal Investigator
  
  Yamakuchi Munekazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Intra-platelet peptide as a diagnostic molecule of bone marrow function
- Principal Investigator
  
  Hashiguchi Teruto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Identification of the significance of HMGB1 measurement in the lifestyle-related diseasePrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
The role of microRNA in diabetes associated vascular dysfunction
- Principal Investigator
  
  MUNEKAZU Yamakuchi
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Contribution of vascular permeability for aging erythrocyte selection in spleen
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Immunomodulatory effects ofB cell derivedVEGF-A in mice
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kagoshima University
Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule
- Principal Investigator
  
  KAWAHARA Ko-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
  Kagoshima University
炎症性の生理活性をもつ“新規アディポサイトカインとしてのHMGB1"の提唱Principal Investigator
- Principal Investigator
  
  清水利昭
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
Defense system by thrombin-HMGB1 axis
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University

All 2019 2018 2017 2016 2015 2014 2013 2012 2009 Other

All Journal Article Presentation Book Patent

[Book] 医薬ジャーナル2012
- Author(s)
  橋口照人、清水利昭、竹之内和則
- Total Pages
  7
- Publisher
  新しい抗凝固薬・抗血小板薬
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer2019
- Author(s)
  Aryal Bibek、Yamakuchi Munekazu、Shimizu Toshiaki、Kadono Jun、Furoi Akira、Gejima Kentaro、Komokata Teruo、Koriyama Chihaya、Hashiguchi Teruto、Imoto Yutaka
- Journal Title
  
  Journal of Oncology
  
  Volume: 2019 Pages: 1-8
- DOI
  10.1155/2019/1925315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19523, KAKENHI-PROJECT-16H05229, KAKENHI-PROJECT-18H02734
[Journal Article] Deciphering Platelet Kinetics in Diagnostic and Prognostic of Hepatocellular Carcinoma2018
- Author(s)
  Bibek Aryal, Munekazu Yamakuchi, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Teruo Komokata, Kentaro Gejima, Teruto Hashiguchi, Yutaka Imoto
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05229
[Journal Article] Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma2018
- Author(s)
  Aryal Bibek、Yamakuchi Munekazu、Shimizu Toshiaki、Kadono Jun、Furoi Akira、Gejima Kentaro、Komokata Teruo、Hashiguchi Teruto、Imoto Yutaka
- Journal Title
  
  Canadian Journal of Gastroenterology and Hepatology
  
  Volume: 2018 Pages: 1-9
- DOI
  10.1155/2018/9142672
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19523, KAKENHI-PROJECT-16H05229, KAKENHI-PROJECT-18H02734, KAKENHI-PROJECT-18F16420, KAKENHI-PROJECT-16K10130
[Journal Article] Therapeutic implication of platelets in liver regeneration ?hopes and hues2018
- Author(s)
  Aryal Bibek、Yamakuchi Munekazu、Shimizu Toshiaki、Kadono Jun、Furoi Akira、Gejima Kentaro、Komokata Teruo、Hashiguchi Teruto、Imoto Yutaka
- Journal Title
  
  Expert Review of Gastroenterology & Hepatology
  
  Volume: 12 Issue: 12 Pages: 1219-1228
- DOI
  10.1080/17474124.2018.1533813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19523, KAKENHI-PROJECT-16H05229, KAKENHI-PROJECT-18H02734
[Journal Article] Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?2017
- Author(s)
  Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Kitazono I, Koriyama C, Yamakuchi M, Hashiguchi T, Imoto Y.
- Journal Title
  
  J Cancer
  
  Volume: 8 Issue: 19 Pages: 3984-3991
- DOI
  10.7150/jca.20971
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05229, KAKENHI-PROJECT-16F16420
[Journal Article] Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner.2017
- Author(s)
  Panta S, Yamakuchi M, Shimizu T, Takenouchi K, Oyama Y, Koriyama T, Kojo T, Hashiguchi T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 483 Issue: 2 Pages: 803-809
- DOI
  10.1016/j.bbrc.2016.12.096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05229, KAKENHI-PROJECT-26293130, KAKENHI-PROJECT-15K15196, KAKENHI-PROJECT-15K15197
[Journal Article] A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans2016
- Author(s)
  Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Inoue M, Ikeda S, Fukukura Y, Nakamura M, Yamakuchi M, Hashiguchi T, Imoto Y
- Journal Title
  
  PLoS One
  
  Volume: 11(3) Issue: 3 Pages: e0150446-e0150446
- DOI
  10.1371/journal.pone.0150446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15196, KAKENHI-PROJECT-15K15197, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-26293130, KAKENHI-PROJECT-16H05229
[Journal Article] HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin2016
- Author(s)
  Toshiaki Shimizu, Munekazu Yamakuchi, Kamal K Biswas, Bibek Aryal, Shingo Yamada, Teruto Hashiguchi and Ikuro Maruyama
- Journal Title
  
  Obesity
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460693
[Journal Article] Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc2009
- Author(s)
  Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK, Nawa Y, Meng X, Oyama Y, Takenouchi K, Shrestha B, Sameshima H, Shimizu T, Adachi T, Adachi M, Maruyama I
- Journal Title
  
  Int J Mol Med
  
  Volume: 23 Pages: 615-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Patent] がん転移マーカーおよびそれを用いた診断2012
- Inventor(s)
  橋口照人夏越祥次佐々木健奥村浩内門泰斗竹之内和則清水利昭田中憲次李良子野中大輔
- Industrial Property Rights Holder
  鹿児島大学他
- Industrial Property Number
  2012-168064
- Filing Date
  2012-07-30
- Data Source
  KAKENHI-PROJECT-22390179
[Presentation] PDGF-BB低値はHCC切除後再発のリスク因子なのか、単なる指標なのか?2018
- Author(s)
  アリアル・ビベック, 清水利昭, 門野潤, 風呂井彰, 槐島健太郎, 菰方輝夫, 郡山千早, 山口宗一, 橋口照人, 井本浩
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] Tracking the signaling pathway for the anti-angiogenic activity of proinflammatory factor TNF alpha2017
- Author(s)
  Sushil Panta、山口宗一、清水利昭、竹之内和則、大山陽子、郡山豊泰、古城　剛、橋口照人
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] Intra-Platelet Serotonin After Partial Hepatectomy: A Candidate Predictor of HCC recurrence2017
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Teruo Komokata, Munekazu Yamakuchi ,Teruto Hashiguchi ,Yutaka Imoto
- Organizer
  Sixth Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA) and the 29th meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] CalDAG-GEFI分子異常による血小板機能異常症2017
- Author(s)
  古城　剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、波野史典、Sushil Panta 、松下昌風、丸山征郎、髙嶋　博、橋口照人
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] Platelet-derived Growth Factors Predict HCC Recurrence After Partial Hepatectomy in Humans2017
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Teruo Komokata, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto
- Organizer
  Twenty-eighth Japanese society of Clinical Chemistry
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] Platelet derived growth factors predict HCC recurrence after partial hepatectomy in humans2017
- Author(s)
  Bibek Aryal、清水利昭、門野　潤、風呂井　彰、山口宗一、菰方輝夫、橋口照人、井本　浩
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] CalDAG-GEFI分子異常による血小板機能異常症2017
- Author(s)
  古城　剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、波野史典、Sushil Panta 、松下昌風、丸山征郎、髙嶋　博、橋口照人
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] Platelet derived growth factors predict HCC recurrence after partial hepatectomy in humans2017
- Author(s)
  Bibek Aryal、清水利昭、門野　潤、風呂井　彰、山口宗一、菰方輝夫、橋口照人、井本　浩
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] Tracking the signaling pathway for the anti-angiogenic activity of proinflammatory factor TNF alpha2017
- Author(s)
  Sushil Panta、山口宗一、清水利昭、竹之内和則、大山陽子、郡山豊泰、古城　剛、橋口照人
- Organizer
  第62回日本臨床検査医学会　九州地方会　第28回日本臨床化学会　九州支部総会
- Place of Presentation
  久留米大学病院　筑水会館（福岡県久留米市）
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] L.pneumophila感染マクロファージ系細胞におけるmiRNAの役割2016
- Author(s)
  山口宗一, 郡山豊泰, 古城剛, 竹之内和則, 清水利昭, 大山陽子, 松下昌風, 橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] L.pneumophila感染マクロファージ系細胞におけるmiRNAの役割2016
- Author(s)
  山口宗一、郡山豊泰、古城　剛、竹之内和則、清水利昭、大山陽子、松下昌風、橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム～I・RA・KA～(奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] miRNAによる自然免疫制御機構の解明2016
- Author(s)
  山口宗一, 郡山豊泰, 向原公介, 重久喜哉, 古城剛, 清水利昭, 竹之内和則, 大山陽子, 井本浩, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆, 清水利昭, 大山陽子, 郡山豊泰, Panta Sushil, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] L.pneumophila感染マクロファージ系細胞におけるmiRNAの役割2016
- Author(s)
  山口宗一、郡山豊泰、古城　剛、竹之内和則、清水利昭、大山陽子、松下昌風、橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム～I・RA・KA～(奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆史, 清水利昭, 大山陽子, 郡山豊泰, Sushil Panta, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] miR-22の血管内皮細胞での役割の検討2016
- Author(s)
  竹中大喜, 山口宗一, 竹之内和則, 大山陽子, 清水利昭, 郡山豊泰, 古城剛, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城　剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、Sushil Panta 、松下昌風、丸山征郎、髙嶋　博、橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム～I・RA・KA～（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城　剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、Sushil Panta 、松下昌風、丸山征郎、髙嶋　博、橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム～I・RA・KA～（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] miR-22の血管内皮細胞での役割の検討2016
- Author(s)
  竹中大喜, 山口宗一, 竹之内和則, 大山陽子, 清水利昭, 郡山豊泰, 古城剛, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] Co-operation of TNFalpha and VEGF to regulate PAI-1 through synergistically upregulated p532016
- Author(s)
  Sushil Panta, Munekazu Yamakuchi, Toshiaki Shimizu, Kazunori Takenouchi, Yoko Oyama, Teruto Hashiguchi
- Organizer
  The 1st Joint Meeting of ISFP and PA Workshop
- Place of Presentation
  Nippondaira Hotel（静岡県静岡市）
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] Co-operation of TNFalpha and VEGF to regulate PAI-1 through synergistically upregulated p532016
- Author(s)
  Sushil Panta, Munekazu Yamakuchi, Toshiaki Shimizu, Kazunori Takenouchi, Yoko Oyama, Teruto Hashiguchi
- Organizer
  XXlllrd International Congress on Fibrinolysis & Proteolysis and XVlth International Workshop on Molecular and Cellular Biology of Plasminogen Activation
- Place of Presentation
  Nippondaira Hotel, Nihondaira, Shizuoka, Japan（静岡県静岡市）
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆, 清水利昭, 大山陽子, 郡山豊泰, Panta Sushil, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] L.pneumophila感染マクロファージ系細胞におけるmiRNAの役割2016
- Author(s)
  山口宗一, 郡山豊泰, 古城剛, 竹之内和則, 清水利昭, 大山陽子, 松下昌風, 橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] Co-operation of TNFalpha and VEGF to regulate PAI-1 through synergistically upregulated p532016
- Author(s)
  Sushil Panta, Munekazu Yamakuchi, Toshiaki Shimizu, Kazunori Takenouchi, Yoko Oyama, Teruto Hashiguchi
- Organizer
  The 1st Joint Meeting of ISFP and PA Workshop
- Place of Presentation
  Nippondaira Hotel（静岡県静岡市）
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] miRNAによる自然免疫制御機構の解明2016
- Author(s)
  山口宗一, 郡山豊泰, 向原公介, 重久喜哉, 古城剛, 清水利昭, 竹之内和則, 大山陽子, 井本浩, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] Co-operation of TNFalpha and VEGF to regulate PAI-1 through synergistically upregulated p532016
- Author(s)
  Sushil Panta, Munekazu Yamakuchi, Toshiaki Shimizu, Kazunori Takenouchi, Yoko Oyama, Teruto Hashiguchi
- Organizer
  XXlllrd International Congress on Fibrinolysis & Proteolysis and XVlth International Workshop on Molecular and Cellular Biology of Plasminogen Activation
- Place of Presentation
  Nippondaira Hotel, Nihondaira, Shizuoka, Japan（静岡県静岡市）
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05229
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆史, 清水利昭, 大山陽子, 郡山豊泰, Sushil Panta, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] L.pneumophila感染単核系細胞におけるmiRNA解析2015
- Author(s)
  郡山豊泰、山口宗一、竹之内和則、大山陽子、清水利昭、橋口照人
- Organizer
  第62回日本臨床検査医学会
- Place of Presentation
  岐阜県岐阜市　長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] Regulation of Tumor Development by microRNAs- Do microRNAs link to cancer-associated thrombosis?2015
- Author(s)
  Munekazu Yamakuchi，Toshiaki Shimizu，Kazunori Takenouchi，Yoko Oyama，and Teruto Hashiguchi
- Organizer
  第37回日本血栓止血学会学術集会学術推進委員会（SPC）シンポジウム1
- Place of Presentation
  山梨県甲府市　甲府市総合市民会館
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] A bidirectional role of platelet sequestered vascular endothelial growth factor-A in cancer and liver regeneration.2015
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Maki Inoue, Teruo Komokata, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto.
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  岐阜県岐阜市長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] Platelet modulates the angiogenic phase of liver regeneration after partial hepatectomy in humans.2015
- Author(s)
  Bibek Aryal, Toshiaki shimizu, Jun Kadono, Akira Furoi, Munekazu Yamakuchi, Teruo Komokata, Teruto Hashiguchi ,Yutaka Imoto
- Organizer
  第60回　日本臨床検査医学会　九州地方会・第26回　日本臨床化学会　九州支部総会
- Place of Presentation
  鹿児島大学　医学部
- Year and Date
  2015-03-07
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] Regulation of Tumor Development by microRNAs - Do microRNAs link to cancer-associated thrombosis?2015
- Author(s)
  Munekazu Yamakuchi，Toshiaki Shimizu，Kazunori Takenouchi，Yoko Oyama，and Teruto Hashiguchi
- Organizer
  第37回日本血栓止血学会学術集会学術推進委員会（SPC）シンポジウム1
- Place of Presentation
  山梨県甲府市　甲府市総合市民会館
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] Platelet Mediated Angiogenesis During Liver regeneration After Partial　Hepatectomy In Humans.2015
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Maki Inoue, Teruo Komokata, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto.
- Organizer
  第27回日本肝胆膵外科学会学術集会
- Place of Presentation
  東京都港区ホテルグランパシフィック LE DAIBA
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K15197
[Presentation] Platelet Mediated Angiogenesis During Liver regeneration After Partial　Hepatectomy In Humans.2015
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Maki Inoue, Teruo Komokata, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto.
- Organizer
  第27回日本肝胆膵外科学会学術集会
- Place of Presentation
  東京都港区　ホテルグランパシフィック LE DAIBA
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] HMGB1は大型脂肪細胞から分泌される炎症性のアディポサイトカインでありインスリン抵抗性を誘導する2015
- Author(s)
  清水利昭, 山口宗一, 竹之内和則, 丸山征郎、橋口照人
- Organizer
  第55回日本臨床化学会年次学術集会
- Place of Presentation
  大阪府吹田市　大阪大学　コンベンションセンター
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25460693
[Presentation] L.pneumophila感染単核系細胞におけるmiRNA解析2015
- Author(s)
  郡山豊泰、山口宗一、竹之内和則、大山陽子、清水利昭、橋口照人
- Organizer
  第62回日本臨床検査医学会
- Place of Presentation
  岐阜県岐阜市　長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] A bidirectional role of platelet sequestered vascular endothelial growth factor-A in cancer and liver regeneration.2015
- Author(s)
  Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Maki Inoue, Teruo Komokata, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto.
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  岐阜県岐阜市　長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] アディポネクチンは新規炎症性アディポサイトカインHMGB1の分泌をJNK経由で阻害する2014
- Author(s)
  清水利昭、竹之内和則、山口宗一、橋口照人
- Organizer
  第59回日本臨床検査医学会九州地方会第25回日本臨床化学会合同プログラム
- Place of Presentation
  熊本市医師会館
- Year and Date
  2014-03-15
- Data Source
  KAKENHI-PROJECT-25893192
[Presentation] マイクロRNAによる直腸がん細胞の低酸素応答制御2013
- Author(s)
  山口宗一、清水利昭、竹之内和則、大山陽子、橋口照人
- Organizer
  第60回　日本臨床検査医学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] マイクロRNAによる直腸がん細胞の低酸素応答制御2013
- Author(s)
  山口宗一、清水利昭、竹ノ内和則、大山陽子、郡山豊康、橋口照人
- Organizer
  第60回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25893192
[Presentation] マイクロRNAによる直腸がん細胞の低酸素応答制御2013
- Author(s)
  山口宗一、清水利昭、竹ノ内和則、大山陽子、郡山豊康、橋口照人
- Organizer
  日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25893192
[Presentation] マイクロRNAによる直腸がん細胞の低酸素応答制御2013
- Author(s)
  山口宗一、清水利昭、竹之内和則、大山陽子、橋口照人
- Organizer
  第60回　日本臨床検査医学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24659282
[Presentation] New adipocytokine HMGB1 inhibits insulin signaling in adipocyte and adiponectin suppresses this effect2013
- Author(s)
  Toshiaki Shimizu, Munekazu Yamakuchi, Shingo Yamada, Masanori Nakata, Teruto Hashiguchi, and Ikuro Maruyama
- Organizer
  The Merinoff world Congress
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-25893192
[Presentation] New Adipocytokine HMGB1 Inhibits Insulin Signaling in Adipocytes and Suppressed by Adiponection.2013
- Author(s)
  Shimizu T, Yamakuchi M, Nakata M, Hashiguchi T, Maruyama I.
- Organizer
  Ｍｅｒｉｎｏｆｆ　Ｗｏｒｌｄ　Ｃｏｎｇｒｅｓｓ　ＨＭＧＢ１
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] New Adipocytokine HMGB1 Inhibits Insulin Signaling in Adipocytes and Suppressed by Adiponection.2013
- Author(s)
  Shimizu T, Yamakuchi M, Nakata M, Hashiguchi T, Maruyama I.
- Organizer
  Merinoff World Congress 2013: HMGB1
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-24659282
[Presentation] 内臓平滑筋 human VEGF-A 発現マウスにおける膵インスリン陽性細胞の構築変化2012
- Author(s)
  竹之内和則、永里朋香、清水利明、丸山征郎、橋口照人
- Organizer
  第59回日本臨床検査医学会学術集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390179
[Presentation] Automatic Integration of All Laboratory Data in the Analysis Server Supporting
- Author(s)
  M. Yamakuchi, Y. Oyama, K. Takenouchi, T. Ito, T. Shimizu, M. Matsushita, T. Hashiguchi
- Organizer
  The 9th Cherry Bloosom Symposium
- Place of Presentation
  Yokohama, Japan（横浜赤レンガ倉庫1号館）
- Year and Date
  2014-04-17 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] 直腸がんの血管新生を制御するマイクロRNAの検討
- Author(s)
  山口宗一, 清水利昭, 竹之内和則, 大山陽子, 郡山豊秦, 伊藤隆史, 橋口照人
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡(福岡国際会議場）
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] アディポネクチンは新規炎症性アディポサイトカインHMGB1の分泌をJNKを介して阻害する
- Author(s)
  清水　トシアキ
- Organizer
  第25回日本臨床化学会　第59回日本臨床検査医学会　九州地方会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460693
[Presentation] Hemophagocytosis as a process of fine tuning immune system in vivo
- Author(s)
  Shrestha Binita　伊藤隆史　郡山豊泰　竹之内和則　大山陽子　清水利昭　山口宗一　丸山征郎　橋口照人
- Organizer
  第61回　日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-24659282
[Presentation] マイクロRNAによる直腸がん血管新生制御機構の解明
- Author(s)
  山口宗一、清水利昭、竹之内和則、大山陽子、橋口照人
- Organizer
  第36回血栓止血学術集会
- Place of Presentation
  大阪（大阪国際交流センター）
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-26293130
[Presentation] Platelet's angiogenic role during liver regeneration
- Author(s)
  Bibek Aryal、清水利昭、古城　剛、門野　潤、菰方輝夫、風呂井　彰、松下昌風、山口宗一、橋口照人、井本　浩
- Organizer
  第61回　日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-25293132
[Presentation] HMGB1 は炎症性のアディポサイトカインでインスリンシグナルを阻害する
- Author(s)
  清水利昭、山口宗一、竹之内和則、橋口照人、丸山征郎
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-25460693

1. HASHIGUCHI Teruto (70250917)

# of Collaborated Projects: 12 results

# of Collaborated Products: 62 results
2. OYAMA Yoko (20583470)

# of Collaborated Projects: 9 results

# of Collaborated Products: 35 results
3. TAKENOUCHI Kazunori (30646758)

# of Collaborated Projects: 9 results

# of Collaborated Products: 38 results
4. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
5. YAMAKUCHI Munekazu (20325814)

# of Collaborated Projects: 6 results

# of Collaborated Products: 50 results
6. KAWAHARA Koichi (10381170)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. ITO Takashi (20381171)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
8. KAWANO YOSHIFUMI (20260680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE OSAMU (30511802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 夏越祥次 (70237577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 村永文学 (00325812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 宇都由美子 (50223582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 原田陽一郎 (80464147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 郡山豊泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Toshiaki 清水 利昭

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HMGB1による疼痛発症のメカニズム―カリクレイン・キニン系からの解析Principal Investigator

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Identification of the significance of HMGB1 measurement in the lifestyle-related diseasePrincipal Investigator

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炎症性の生理活性をもつ“新規アディポサイトカインとしてのHMGB1"の提唱Principal Investigator

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[Book] 医薬ジャーナル2012

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[Journal Article] Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer2019

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SHIMIZU Toshiaki 清水利昭