Harada Yoichiro 原田陽一郎

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HARADA Yoichiro 原田陽一郎

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Researcher Number	80464147
Other IDs	https://orcid.org/0000-0003-1818-9633
Affiliation (Current)	2025: 名古屋大学, 糖鎖生命コア研究所, 特任教授 2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部主任研究員
Affiliation (based on the past Project Information) *help	2024: 名古屋大学, 糖鎖生命コア研究所, 特任教授 2023: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部主任研究員 2019 – 2021: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部主任研究員 2019: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部チームリーダー 2015 – 2018: 鹿児島大学, 医歯学総合研究科, 特任准教授 … More 2016: 国立研究開発法人理化学研究所, 糖鎖代謝学研究チーム, 特別研究員 2015: 鹿児島大学, 医歯(薬)学総合研究科, 特任准教授 2012 – 2014: 独立行政法人理化学研究所, 糖鎖代謝学研究チーム, 特別研究員 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 50010:Tumor biology-related / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Emergency medicine / Basic Section 52010:General internal medicine-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Veterinary medical science / Functional biochemistry / Laboratory medicine
Keywords	Principal Investigator 糖代謝 / がん / 代謝 / アスパラギン結合型糖鎖 / 遊離糖鎖 / 糖鎖生物学 / マンノースリン酸イソメラーぜ / DNA障害型抗がん剤 / マンノース / トレーサーメタボロミクス … More / 細胞外小胞 / 糖鎖修飾 / ワールブルグ効果 / 非エクソソーム小胞 / エクソソーム / アスパラギン結合型糖鎖修飾 / 輸送 / 小胞体 / ドリコール結合型糖鎖 / オリゴ糖転移酵素 / 糖鎖代謝 … More Except Principal Investigator exosome / DIC / HMGB1 / DAMPs / エクソソーム / Thrombomodulin / トロンボモジュリン / DAMPｓ / Exosome / microRNA / Histones / PAMPs / 血管内皮細胞 / miRNA / ASO / 血管内皮機能 / 動脈硬化 / shock / skimming / sludging / Thrombomodulin(TM) / Blood sludging / Blood skimming / 組織因子 / 第Ⅶ因子 / 血栓塞栓症 / 癌 / blood sludging / blood skimming / Trousseau syndrome / Thrombosis / Cancer Procoagulant / 血球成分 / 血漿成分 / 出血 / 血栓・塞栓 / T-TAS / Sludging / Skimming / 血流動態異常 / protein C / thrombin / RAMPs / EPCR / Protein C / TM / Thrombin / 修復 / 止血 / 組織損傷 / プロテインC / 生体損傷 / RAMPｓ / PAMPｓ / small RNA / エキソソーム / イヌ腫瘍 / non-coding RNA / 診断・治療 / 犬腫瘍 / イヌ / 乳腺腫瘍 / 肝細胞癌 / メラノーマ / 犬 / 腫瘍 / マイクロRNA / ノンコーディングRNA / 遊離糖鎖 / 代謝 / 糖鎖 / 糖タンパク質 / O型糖鎖 / O-マンノース / オリゴ糖転移酵素 / PNGase / N型糖鎖 / 出芽酵母 / 糖鎖代謝 / ヒストン / alarmins / Organ failure / ARDS / NETosis / アポトーシス / ネクローシス / プログラム細胞死 / 白血球 / 血栓 / 生理学 / 生体分子 / シグナル伝達 / 細胞・組織 / トランスレーショナルリサーチ / inflammation / thrombosis / programmed cell death / eryptosis / 赤血球 / molecular clock / program cell death / apoptosis / erythrocyte / 肝癌 / セロトニン / 血小板 / prognosis / exhaust platelet / hepatocellular carcinoma / serotonin / VEGF-A / platelet / メラノーマ細胞株A375 / Alix / Heat shock protein / 糖鎖構造 Less

Elucidation of the anti-cancer mechanisms of mannosePrincipal Investigator
- Principal Investigator
  
  原田陽一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya University
  Osaka International Cancer Institute
Elucidation of the role of Warburg effect in the secretion of tumor exosomesPrincipal Investigator
- Principal Investigator
  
  Harada Yoichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Osaka International Cancer Institute
Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kagoshima University
Construction of A New Paradigm for Diagnosis and Treatment of Atherosclerosis Obliterans
- Principal Investigator
  
  Yamakuchi Munekazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kagoshima University
Establishment of smart-diagnosis&treatment for canine tumor by exosome
- Principal Investigator
  
  Miura Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kagoshima University
Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Analysis for pro grammed cell death of anuclear platelets and erythrocytes for application of laboratory medicine
- Principal Investigator
  
  Hashiguchi Teruto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Pathophysiological significance of two types of DAMPs, naked- and exosomal type.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Studies on metabolic pathway of free oligosaccharides generated in the ER lumenPrincipal Investigator
- Principal Investigator
  
  Harada Yoichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagoshima University
  The Institute of Physical and Chemical Research
Clarification of molecular mechanism for the catabolism of glycans on glycoproteins in budding yeast
- Principal Investigator
  
  Tadashi Suzuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Institute of Physical and Chemical Research
Generation mechanism of free oligosaccharides in the lumen of the endoplasmic reticulumPrincipal Investigator
- Principal Investigator
  
  HARADA Yoichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2021 2020 2019 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] OST complex (OST48, Ribophorin I, Ribophorin II, DAD1) in “Handbook of glycosyltransferases and related genes. 2nd Edition” (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, T. Angata eds.)2014
- Author(s)
  Yoichiro Harada and Tadashi Suzuki
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25291030
[Book] OST complex (OST48, Ribophorin I, Ribophorin II, DAD1) (Vol.3, 1255-1272). In "Handbook of glycosyltransferases and related genes. 2nd Edition" (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, T. Angata eds.)2014
- Author(s)
  Yoichiro Harada and Tadashi Suzuki
- Total Pages
  1707
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25291030
[Journal Article] Manipulating mannose metabolism as a potential anticancer strategy2024
- Author(s)
  Harada Yoichiro
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 7 Pages: 1505-1519
- DOI
  10.1111/febs.17230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06645
[Journal Article] Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells2023
- Author(s)
  Harada Yoichiro、Mizote Yu、Suzuki Takehiro、Hirayama Akiyoshi、Ikeda Satsuki、Nishida Mikako、Hiratsuka Toru、Ueda Ayaka、Imagawa Yusuke、Maeda Kento、Ohkawa Yuki、Murai Junko、Freeze Hudson H、Miyoshi Eiji、Higashiyama Shigeki、Udono Heiichiro、Dohmae Naoshi、Tahara Hideaki、Taniguchi Naoyuki
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83870
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06420, KAKENHI-PROJECT-23K06625, KAKENHI-PROJECT-23K06645, KAKENHI-PROJECT-23K06734, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-23K24228
[Journal Article] Extracellular Vesicles and Glycosylation2021
- Author(s)
  Harada Yoichiro、Ohkawa Yuki、Maeda Kento、Kizuka Yasuhiko、Taniguchi Naoyuki
- Journal Title
  
  The Role of Glycosylation in Health and Disease
  
  Volume: 1325 Pages: 137-149
- DOI
  10.1007/978-3-030-70115-4_6
- ISBN
  9783030701147, 9783030701154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06546, KAKENHI-PROJECT-20K07629
[Journal Article] Protocol for analyzing the biosynthesis and degradation of N-glycan precursors in mammalian cells2021
- Author(s)
  Harada Y, Nakajima K, Li S, Suzuki T, Taniguchi N.
- Journal Title
  
  STAR Protoc.
  
  Volume: 2 Issue: 1 Pages: 100316-100316
- DOI
  10.1016/j.xpro.2021.100316
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08257, KAKENHI-PROJECT-19K06546
[Journal Article] Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles2020
- Author(s)
  Harada Yoichiro、Nakajima Kazuki、Suzuki Takehiro、Fukushige Tomoko、Kondo Kiyotaka、Seino Junichi、Ohkawa Yuki、Suzuki Tadashi、Inoue Hiromasa、Kanekura Takuro、Dohmae Naoshi、Taniguchi Naoyuki、Maruyama Ikuro
- Journal Title
  
  Cell Reports
  
  Volume: 33 Issue: 2 Pages: 108261-108261
- DOI
  10.1016/j.celrep.2020.108261
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06546, KAKENHI-PROJECT-20K07629, KAKENHI-PROJECT-18K08257, KAKENHI-PROJECT-18H03990
[Journal Article] Generation of the heterogeneity of extracellular vesicles by membrane organization and sorting machineries2019
- Author(s)
  Harada Yoichiro、Suzuki Takehiro、Fukushige Tomoko、Kizuka Yasuhiko、Yagi Hirokazu、Yamamoto Mika、Kondo Kiyotaka、Inoue Hiromasa、Kato Koichi、Taniguchi Naoyuki、Kanekura Takuro、Dohmae Naoshi、Maruyama Ikuro
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1863 Issue: 4 Pages: 681-691
- DOI
  10.1016/j.bbagen.2019.01.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07356, KAKENHI-PROJECT-18K06914, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15K14481, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] N‐glycome inheritance from cells to extracellular vesicles in B16 melanomas2019
- Author(s)
  Harada Yoichiro、Kizuka Yasuhiko、Tokoro Yuko、Kondo Kiyotaka、Yagi Hirokazu、Kato Koichi、Inoue Hiromasa、Taniguchi Naoyuki、Maruyama Ikuro
- Journal Title
  
  FEBS Letters
  
  Volume: 印刷中 Issue: 9 Pages: 942-951
- DOI
  10.1002/1873-3468.13377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07356, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-18K06914
[Journal Article] Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles2019
- Author(s)
  Yamamoto Mika、Harada Yoichiro、Suzuki Takehiro、Fukushige Tomoko、Yamakuchi Munekazu、Kanekura Takuro、Dohmae Naoshi、Hori Kanji、Maruyama Ikuro
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 580 Pages: 21-29
- DOI
  10.1016/j.ab.2019.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08272, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02734, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19523, KAKENHI-PROJECT-18K19587
[Journal Article] Lack of the evidence for the enzymatic catabolism of Man1GlcNAc2 in Saccharomyces cerevisiae.2016
- Author(s)
  Tanim Jabid Hossain, Hiroto Hirayama, Yoichiro Harada and Tadashi Suzuki
- Journal Title
  
  Bioscience, Biotechnology and Biochemistry
  
  Volume: 80 Issue: 1 Pages: 152-157
- DOI
  10.1080/09168451.2015.1072464
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291030
[Journal Article] tructural analysis of free N-glycans in alpha-glucosidase mutants of Saccharomyces cerevisiae. Lack of the evidence for the occurrence of catabolic a-glucosidase acting on the N-glycans.2016
- Author(s)
  Tanim Jabid Hossain, Yoichiro Harada, Hiroto Hirayama, Haruna Tomotake, Akira Seko and Tadashi Suzuki
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0151891-e0151891
- DOI
  10.1371/journal.pone.0151891
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25291030
[Journal Article] Non-lysosomal degradation of phophorylated oligosaccharides is initiated by the cytosolic endo-beta-N-acetylglucosaminidase.2016
- Author(s)
  Y. Harada, C Huang, S. Yamaki, N. Dohmae, and T. Suzuki
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 15 Pages: 8048-8058
- DOI
  10.1074/jbc.m115.685313
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-26650040
[Journal Article] Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells.2015
- Author(s)
  Chengcheng Huang, Yoichiro Harada, Akira Hosom, Yuki Masahara-Negishi, Junichi Seino, Haruhiko Fujihira, Yoko Funakoshi, Takehiro Suzuki, Naoshi Dohmae, Tadashi Suzuki
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Issue: 5 Pages: 1398-1403
- DOI
  10.1073/pnas.1414593112
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-26650040
[Journal Article] Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells.2015
- Author(s)
  Y. Harada, Y. Masahara-Negishi, and T. Suzuki.
- Journal Title
  
  Glycobiology
  
  Volume: 25 Issue: 11 Pages: 1196-1205
- DOI
  10.1093/glycob/cwv055
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-26650040
[Journal Article] Generation and degradation of free asparagine-linked glycans.2015
- Author(s)
  Yoichiro Harada, Hiroto Hirayama, and Tadashi Suzuki
- Journal Title
  
  Cell Mol. Life Sci.
  
  Volume: NA Issue: 13 Pages: 2509-2533
- DOI
  10.1007/s00018-015-1881-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291030, KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-26650040
[Journal Article] Non-lysosomal degradation pathway for N-linked glycans and dolichol linked oligosaccharides2014
- Author(s)
  Tadashi Suzuki and Yoichiro Harada
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 453 Issue: 2 Pages: 213-219
- DOI
  10.1016/j.bbrc.2014.05.075
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291030, KAKENHI-PROJECT-26650040
[Journal Article] Interaction of 70-kDa heat shock protein with glycosaminoglycans and acidic glycopolymers2014
- Author(s)
  Yoichiro Harada, Estelle Garenaux, Takehiro Nagatsuka, Hirotaka Uzawa, Yoshihiro Nishida, Chihiro Sato, Ken Kitajima
- Journal Title
  
  Biochem. Biophys. Res. Communication
  
  Volume: 453 Issue: 2 Pages: 229-234
- DOI
  10.1016/j.bbrc.2014.05.137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450146, KAKENHI-PROJECT-26650040
[Journal Article] Metabolically programmed quality control system for dolichol-linked oligosaccharides2013
- Author(s)
  Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, Suzuki T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Issue: 48 Pages: 19366-19371
- DOI
  10.1073/pnas.1312187110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770134, KAKENHI-PROJECT-25291030
[Journal Article] Eukaryotic oligosaccharyltransferase generates free oligosaccharides during N-glycosylation2013
- Author(s)
  Harada Y, Buser R, Ngwa EM, Hirayama H, Aebi M, Suzuki T
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 45 Pages: 32673-32684
- DOI
  10.1074/jbc.m113.486985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770134, KAKENHI-PROJECT-25291030
[Presentation] マンノース代謝にプログラムされたゲノム安定化機構2024
- Author(s)
  原田陽一郎
- Organizer
  第97回日本生化学会大会（3S13m「グライコスタシス：超マルチタスク分子、“糖”の新機軸」）
- Data Source
  KAKENHI-PROJECT-23K06645
[Presentation] マンノースリン酸イソメラーゼによる中心代謝の制御機構の解明に向けて2024
- Author(s)
  原田陽一郎、平山明由、池田五月、真鍋法義、栗原大輝、藤田晶大、長江雅倫、木下聖子、山口芳樹、東山繁樹、谷口直之
- Organizer
  第43回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-23K06645
[Presentation] Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells2023
- Author(s)
  Yoichiro Harada, Yu Mizote, Takehiro Suzuki, Akiyoshi Hirayama, Mikako Nishida, Toru Hiratsuka, Yusuke Imagawa, Junko Murai, Hudson H. Freeze, Eiji Miyoshi, Shigeki Higashiyama, Heiichiro Udono, Naoshi Dohmae, Hideaki Tahara, and Naoyuki Taniguchi
- Organizer
  Society for Glycobiology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06645
[Presentation] Deciphering the context-dependent roles of mannose metabolism in cancer2023
- Author(s)
  Yoichiro Harada
- Organizer
  7th LATIN AMERICAN GLYCOBIOLOGY CONGRESS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06645
[Presentation] マンノース：敵か味方か？2023
- Author(s)
  原田陽一郎
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06645
[Presentation] 細胞外小胞を介したがんと宿主との相互作用におけるN型糖鎖修飾の役割2021
- Author(s)
  原田陽一郎、貫戸紀子、谷口直之
- Organizer
  第40回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] 細胞外小胞に発現する糖鎖の構造、機能およびがんとの関連2021
- Author(s)
  原田　陽一郎、近藤　清貴、中嶋　和紀、中の　三弥子、鈴木　健裕、堀　貫治、矢木　宏和、加藤　晃一、鈴木　匡、堂前　直、金蔵　拓郎、井上　博雅、丸山　征郎、谷口　直之
- Organizer
  第8回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] Protein N-glycosylation modulates the secretion of small extracellular vesicles2021
- Author(s)
  Yoichiro Harada, Kazuki Nakajima, Naoyuki Taniguchi
- Organizer
  2021 ISEV Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] N-glycosylation is critical for the biogenesis of small extracellular vesicles2021
- Author(s)
  Yoichiro Harada, Kazuki Nakajima, Takehiro Suzuki, Tomoko Fukushige, Kiyotaka Kondo, Junichi Seino, Yuki Ohkawa, Tadashi Suzuki, Hiromasa Inoue, Takuro Kanekura, Naoshi Dohmae, Naoyuki Taniguchi, Ikuro Maruyama
- Organizer
  2021 ASBMB Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] The control of tumor progression by targeting sugar metabolism2021
- Author(s)
  Yoichiro Harada
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] Glycan quality control system and its potential role in inducing ER stress in tumor hypoxia2021
- Author(s)
  Yoichiro Harada, Ken Hanzawa, Yu Mizote, Takashi Akazawa, Hideaki Tahara, Yasuhide Miyamoto and Naoyuki Taniguchi
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] がん細胞が分泌する糖鎖依存性の細胞外小胞の発見とその形成機構の解析2020
- Author(s)
  原田　陽一郎、丸山　征郎、谷口　直之
- Organizer
  第１回日本癌学会若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] Glycometabolic regulation of the biogenesis of small extracellular vesicles2020
- Author(s)
  Yoichiro Harada, Kazuki Nakajima, Takehiro Suzuki, Tomoko Fukushige, Kiyotaka Kondo, Junichi Seino, Yuki Ohkawa, Tadashi Suzuki, Hiromasa Inoue, Takuro Kanekura, Naoshi Dohmae, Naoyuki Taniguchi and Ikuro Maruyama
- Organizer
  Society for Glycobiology 2020 Virtual Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] N-glycosylation regulates the secretion of tumor-derived extracellular vesicles2019
- Author(s)
  原田　陽一郎、谷口　直之
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] 糖鎖依存的に分泌される細胞外小胞の同定2019
- Author(s)
  原田　陽一郎、谷口　直之
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] 細胞外小胞の不均一性とその形成におけるN型糖鎖修飾の役割2019
- Author(s)
  原田　陽一郎
- Organizer
  第38回日本糖質学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] 細胞外小胞の分泌におけるN結合型糖鎖修飾の役割2019
- Author(s)
  原田　陽一郎
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06546
[Presentation] Analysis of the catabolic pathway of N-glycans in S. cerevisiae2014
- Author(s)
  Tanim Jabid Hossain, Hiroto Hirayama, Yoichiro Harada and Tadashi Suzuki
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25291030
[Presentation] Role of oligosaccharyltransferase on PNGase-independent release of free oligosaccharides.2014
- Author(s)
  Yoichiro Harada and Tadashi Suzuki (invited speaker)
- Organizer
  GlycoT2014
- Place of Presentation
  Porto (Portugal)
- Year and Date
  2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-25291030
[Presentation] Analysis of the catabolic pathway of N-glycans in S. cerevisiae.2014
- Author(s)
  Tanim Jabid Hossain, Hiroto Hirayama, Yoichiro Harada and Tadashi Suzuki
- Organizer
  GlycoTOKYO2014
- Place of Presentation
  千葉大学
- Year and Date
  2014-11-04
- Data Source
  KAKENHI-PROJECT-25291030
[Presentation] ドリコールオリゴ糖の品質管理機構の同定2013
- Author(s)
  原田陽一郎、中嶋和紀、根岸由紀、安形高志、谷口直之、鈴木匡
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] Yeast oligosaccharyltransferase generates free oligosaccharides during N-glycosylation2013
- Author(s)
  Yoichiro Harada and Tadashi Suzuki
- Organizer
  The Second Symposium RIKEN-Max Planck Joint Research Center for Systems Chemical Biology
- Place of Presentation
  埼玉、理研
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] ドリコールオリゴ糖前駆体の品質管理機構2013
- Author(s)
  原田陽一郎、中嶋和紀、根岸由紀、安形高志、谷口直之、鈴木匡
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪（大阪国際交流センター）
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] The generation of free oligosaccharides in eukaryotes2013
- Author(s)
  Yoichiro Harada
- Organizer
  The 3rd Austria/Japan Seminar on Comparative and Developmental Glycobiology
- Place of Presentation
  埼玉（理化学研究所）
- Invited
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] Yeast oligosaccharyltransferase generates free oligosaccharides during N-glycosylation2013
- Author(s)
  Yoichiro Harada and Tadashi Suzuki
- Organizer
  The Second Symposium RIKEN-Max Planck Joint Research Center for Systems Chemical Biology
- Place of Presentation
  埼玉（理化学研究所）
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] ドリコールオリゴ糖前駆体の品質管理機構2013
- Author(s)
  原田陽一郎、中嶋和紀、正原-根岸由紀、安形高志、谷口直之、鈴木　匡
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪国際交流センター（大阪）
- Data Source
  KAKENHI-PROJECT-25291030
[Presentation] ドリコールオリゴ糖の品質管理機構の同定2013
- Author(s)
  原田陽一郎、中嶋和紀、根岸由紀、安形高志、谷口直之、鈴木匡
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] ドリコールオリゴ糖の品質管理機構の同定2013
- Author(s)
  原田陽一郎、中嶋和紀、正原-根岸由紀、安形高志、谷口直之、鈴木　匡
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25291030
[Presentation] The generation of free oligosaccharides in eukaryotes2013
- Author(s)
  Yoichiro Harada
- Organizer
  The 3^<rd> Austria/Japan Seminar on Comparative and Developmental Glycobiology
- Place of Presentation
  埼玉、理研
- Invited
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] ドリコールオリゴ糖の品質管理機構2013
- Author(s)
  原田陽一郎、中嶋和紀、根岸由紀、安形高志、谷口直之、鈴木匡
- Organizer
  第32回日本糖質学会
- Place of Presentation
  大阪、大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] 酵母オリゴ糖転移酵素の加水分解活性の証明2012
- Author(s)
  原田　陽一郎、鈴木　匡
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] 出芽酵母オリゴ糖転移酵素はN型糖鎖前駆体から糖鎖を遊離する活性を持つ2012
- Author(s)
  原田　陽一郎、鈴木　匡
- Organizer
  第31回　日本糖質学会
- Place of Presentation
  鹿児島市民文化ホール
- Data Source
  KAKENHI-PROJECT-24770134
[Presentation] グルコース飢餓によって誘導されるドリコールオリゴ糖の未成熟分解の発見とその分子機構の解明に向けて
- Author(s)
  原田　陽一郎、鈴木　匡
- Organizer
  日本糖質学会
- Place of Presentation
  名古屋大学、名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-26650040
[Presentation] Metabolically programmed quality control system for dolichol-linked oligosaccharides
- Author(s)
  Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, Suzuki T.
- Organizer
  2014 SFG and JSCR joint meeting, Satellite symposium IV
- Place of Presentation
  Hilton Hawaiian Village, Hawaii
- Year and Date
  2014-11-16 – 2014-11-19
- Invited
- Data Source
  KAKENHI-PROJECT-26650040
[Presentation] Degradation of aberrant dolichol-linked oligosaccharides by a putative pyrophosphatase
- Author(s)
  Harada Y, Suzuki T.
- Organizer
  日本生化学会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26650040
[Presentation] PNGase-independent formation of free oligosaccharides is predominant in mammalian cells
- Author(s)
  Harada Y, Masahara-Negishi Y, Suzuki T.
- Organizer
  2014 SFG and JSCR joint meeting, Satellite symposium II
- Place of Presentation
  Hilton Hawaiian Village, Hawaii
- Year and Date
  2014-11-16 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26650040
[Presentation] Metabolically programmed quality control system for dolichol-linked oligosaccharides
- Author(s)
  Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, Suzuki T.
- Organizer
  2014 SFG and JSCR joint meeting
- Place of Presentation
  Hilton Hawaiian Village, Hawaii
- Year and Date
  2014-11-16 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26650040

1. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMAKUCHI Munekazu (20325814)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. ITO Takashi (20381171)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. Hashiguchi Teruto (70250917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 大山陽子 (20583470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 竹之内和則 (30646758)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 川原幸一 (10381170)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Tadashi Suzuki (90345265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
9. HIRAYAMA Hiroto (50525847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. Miura Naoki (80508036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 村永文学 (00325812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 宇都由美子 (50223582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 清水利昭 (50468055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 福島隆治 (10466922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中川貴之 (40447363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 畑井仁 (40566535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岡本芳晴 (50194410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 後藤章暢 (70283885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 垣花泰之 (20264426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山本美佳 (70791507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KANEKURA Takuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. NAKAJIMA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. UZAWA Hirotaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 木塚康彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 大川祐樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 西田芳弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada Yoichiro 原田 陽一郎

HARADA Yoichiro 原田 陽一郎

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Elucidation of the anti-cancer mechanisms of mannosePrincipal Investigator

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Elucidation of the role of Warburg effect in the secretion of tumor exosomesPrincipal Investigator

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Studies on metabolic pathway of free oligosaccharides generated in the ER lumenPrincipal Investigator

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Generation mechanism of free oligosaccharides in the lumen of the endoplasmic reticulumPrincipal Investigator

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[Book] OST complex (OST48, Ribophorin I, Ribophorin II, DAD1) in “Handbook of glycosyltransferases and related genes. 2nd Edition” (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, T. Angata eds.)2014

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[Book] OST complex (OST48, Ribophorin I, Ribophorin II, DAD1) (Vol.3, 1255-1272). In "Handbook of glycosyltransferases and related genes. 2nd Edition" (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, T. Angata eds.)2014

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[Journal Article] Manipulating mannose metabolism as a potential anticancer strategy2024

Author(s)

Harada Yoichiro 原田陽一郎

HARADA Yoichiro 原田陽一郎