Yoshioka Hirotaka 吉岡広陽

… Alternative Names

Researcher Number	50523411
Other IDs
Affiliation (Current)	2021: 国際医療福祉大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021: 国際医療福祉大学, 医学部, 講師 2017 – 2019: 国際医療福祉大学, 医学部, 講師 2012 – 2016: 広島大学, 医歯薬保健学研究院(歯), 助教 2012: 広島大学, 大学院・医歯薬保健学研究院, 助教 2009 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 助教 2010: Hiroshima University, 医歯(薬)学総合研究科, 助教 2010: 広島大学, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Basic Section 56020:Orthopedics-related Except Principal Investigator Morphological basic dentistry
Keywords	Principal Investigator リン酸代謝 / 石灰化 / 歯 / エナメル質 / エピジェネティクス / 骨代謝 / 骨芽細胞 / 歯牙形成 / 歯胚 / リン代謝 … More Except Principal Investigator FGF23 / 骨芽細胞 / GF23 / Klotho / 石灰化 / マップキナーゼ(ERK) / 可溶型Klotho / 可溶化Klotho(細胞外ドメイン) / 歯・骨の石灰化 / マウス / KLotho / ERK / 細胞・組織 / 骨代謝 / リン代謝 / PTH Less

一細胞遺伝子発現プロファイルに基づく骨芽細胞系譜の分化多様性機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  吉岡広陽
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  International University of Health and Welfare
単一細胞解析による骨芽細胞の運命制御機構の解明と新規骨形成促進剤の標的分子探索Principal InvestigatorOngoing
- Principal Investigator
  
  吉岡広陽
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  International University of Health and Welfare
Development of bone regeneration strategies by controlling the epigenetic state of bone lining cells.Principal Investigator
- Principal Investigator
  
  YOSHIOKA HIROTAKA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
Study of tooth morphogenesis from the aspect of local regulation of phosphate metabolism: An epigenomic approach.Principal Investigator
- Principal Investigator
  
  YOSHIOKA Hirotaka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
A basic study of de novo function of PTH in mineral metabolism disorders
- Principal Investigator
  
  MINAMIZAKI Tomoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
Tooth morphogenesis and the regulation of phosphate homeostasis : basic and preclinical studies of tooth hypoplasiaPrincipal Investigator
- Principal Investigator
  
  YOSHIOKA Hirotaka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
リン酸代謝を分子基盤とした歯の石灰化不全の解析と実験的治療Principal Investigator
- Principal Investigator
  
  吉岡広陽
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University
A basic study on FGF23 for molecular targeted therapy of bone/tooth diseases
- Principal Investigator
  
  YOSHIKO Yuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hiroshima University

All 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice2020
- Author(s)
  Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y
- Journal Title
  
  Communications Biology
  
  Volume: 3
- DOI
  10.1038/s42003-020-0754-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11613, KAKENHI-PROJECT-19K19268
[Journal Article] Soluble Klotho causes hypomineralization in Klotho-deficient mice2018
- Author(s)
  Minamizaki T, Konishi Y, Sakurai K, Yoshioka H, Aubin JE, Kozai K, Yoshiko Y
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 237 Pages: 285-300
- DOI
  10.1530/joe-17-0683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11613
[Journal Article] Comparative proteome analysis of wild-type and klotho-knockout mouse kidneys using a combination of MALDI-IMS and LC-MS/MS.2017
- Author(s)
  Fujino Y, Minamizaki T, Hayashi I, Kawakami A, Miyaji T, Sakurai K, Yoshioka H, Kozai K, Okada M, Yoshiko Y.
- Journal Title
  
  Proteomics Clinical Applications
  
  Volume: 8 Pages: 7-8
- DOI
  10.1002/prca.201600095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460067, KAKENHI-PROJECT-26462785, KAKENHI-PROJECT-17K19489
[Journal Article] Imaging and mapping of mouse bone using MALDI-imaging mass spectrometry.2016
- Author(s)
  Fujino Y, Minamizaki T, Yoshioka H, Okada M, Yoshiko Y
- Journal Title
  
  Bone Reports
  
  Volume: 5 Pages: 280-285
- DOI
  10.1016/j.bonr.2016.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462785
[Journal Article] The dynamics of DNA methylation and hydroxymethylation during amelogenesis.2015
- Author(s)
  Yoshioka H, Minamizaki T, Yoshiko Y.
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: 144 Pages: 471-478
- DOI
  10.1007/s00418-015-1353-z
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462785
[Journal Article] Sequence-specific promoter elements regulate temporal-specific changes in chromatin required for testis-specific activation of the Pgk2 gene2013
- Author(s)
  Yang Z, Yoshioka H, McCarrey JR
- Journal Title
  
  Reproduction
  
  Volume: 146 Pages: 501-516
- DOI
  10.1530/rep-13-0311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791962
[Journal Article] The EP4-ERK-dependent pathway stimulatesosteo-adipogenic progenitor proliferation resulting in increased adipogenesis in fetal rat calvariacell cultures2012
- Author(s)
  Minamizaki T, Yoshiko Y, Yoshioka H, Kozai K, Aubin JE, Maeda N
- Journal Title
  
  Prostaglandins and Other Lipid Mediators
  
  Volume: 97 Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791768
[Journal Article] The EP4-ERK-dependent pathway stimulates osteo-adipogenic progenitor proliferation resulting in increased adipogenesis in fetal rat calvaria cell cultures.2012
- Author(s)
  Minamizaki Tomoko, Yoshiko Yuji, Yoshioka Hirotaka, KOzai Katsuyuki, Aubin Jane E, Maeda Norihiko
- Journal Title
  
  Prostaglandins Other Lipid Mediat.
  
  Volume: 97 Pages: 97-102
- DOI
  10.1016/j.prostaglandins.2012.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592701, KAKENHI-PROJECT-23792105
[Journal Article] Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a12012
- Author(s)
  Yoshioka Hirotaka, Yoshiko Yuji, Minamizaki Tomoko, Suzuki Sayaka, Koma Yoshiro, Nobukiyo Asako, Sotomaru Yusuke, Suzuki Atsushi, Ito Mitsuyasu, Maeda Norihiko
- Journal Title
  
  Calcif Tissue Int
  
  Volume: 89 Pages: 192-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792105
[Journal Article] The EP4-ERK-dependent pathway stimulates osteo-adipogenic progenitor proliferation resulting in increased adipogenesis in fetal rat calvaria cell cultures2012
- Author(s)
  Minamizaki Tomoko, Yoshiko Yuji, Yoshioka Hirotaka, Kozai Katsuyuki, Jane E Aubin, Maeda Norihiko
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 97 Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792105
[Journal Article] Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.2012
- Author(s)
  Hirotaka Yoshioka, Yuji Yoshiko, Tomoko Minamizaki, Sayaka Suzuki, Yoshiro Koma, Asako Nobukiyo, Yusuke Sotomaru, Atsushi Suzuki, Mitsuyasu Itoh, Norihiko Maeda
- Journal Title
  
  Calcif Tissue Int.
  
  Volume: 89 Pages: 192-202
- DOI
  10.1007/s00223-011-9506-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791768, KAKENHI-PROJECT-23592701, KAKENHI-PROJECT-23792105
[Journal Article] Incisor enamel formation is impairedin transgenic rats overexpressing the type III NaPi transporter Slc20a12011
- Author(s)
  Yoshioka H, Yoshiko Y, Minamizaki T, Suzuki S, Koma Y, Nobukiyo A, SotomaruY, Suzuki A, Itoh M and Maeda N
- Journal Title
  
  Calcified Tissue International
  
  Volume: 89 Pages: 192-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791768
[Journal Article] 1・,25-dihydroxy-vitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro.2010
- Author(s)
  Yamamoto R, Minamizaki T, Yoshiko Y, Yoshioka H, et al.
- Journal Title
  
  J Endocrinol 206(3)
  
  Pages: 279-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592139
[Journal Article] 1α, 25(OH) 2D acts predominantly onmature osteoblastic cells under conditions of high extracellular phosphate to increase FGF23 productionin vitro2010
- Author(s)
  Yamamoto R, Minamizaki T, Yoshiko Y, Yoshioka H, Tanne S, Aubin JE, Maeda N
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 206 Pages: 279-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791768
[Journal Article] 低リン血症にみる歯の形成の分子基盤2008
- Author(s)
  吉子裕二, 南崎朋子, 吉岡広陽, 鈴木清香, 前田憲彦
- Journal Title
  
  広島歯誌 36
  
  Pages: 1-12
- Data Source
  KAKENHI-PROJECT-20592139
[Patent] リン酸化ペプチド、硬組織および/または異所性石灰化抑制剤、抗体ならびに硬組織および/または異所性石灰化促進剤2011
- Inventor(s)
  吉子裕二, 南崎朋子, 吉岡広陽, 平田伊佐雄, 香西克之, 前田憲彦, 渡邉和晃, 清藤勉
- Industrial Property Rights Holder
  国立大学法人広島大学, 株式会社ラフィーネインターナショナル, 株式会社免疫生物研究所
- Industrial Property Number
  2011-150487
- Filing Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-23792105
[Patent] 石灰化組織における可溶化Klotho、FGF23およびFGFR複合体形成機構を利用した用途2011
- Inventor(s)
  吉子裕二, 南崎朋子, 吉岡広陽, 前田憲彦, 香西克之, 渡邉和晃
- Industrial Property Rights Holder
  国立大学法人広島大学, 株式会社ラフィーネインターナショナル
- Industrial Property Number
  2011-123853
- Filing Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-23792105
[Patent] 石灰化組織における可溶化Klotho、FGF23およびFGFR複合体形成機構を利用した用途2010
- Inventor(s)
  吉子裕二, 南崎朋子, 吉岡広陽, 他
- Industrial Property Rights Holder
  広島大学,ラフィーネインターナショナル
- Industrial Property Number
  2010-136637
- Filing Date
  2010-06-15
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] A synthetic peptide derived from the SIBLING protein MEPE inhibits ectopic mineralization but not bone formation.2019
- Author(s)
  Minamizaki T, Toshishige M, Yoshioka H, Ahmed F, Mine Y, Yoshiko Y
- Organizer
  World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] シングルセル解析から見た骨芽細胞の多様性と脂肪細胞分化転換能2019
- Author(s)
  中野将志，吉岡広陽，南崎朋子，香西克之，吉子裕二
- Organizer
  第124回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] Plasticity of osteoblasts and their adipogenic potential dissected by single cell RNA-sequencing.2019
- Author(s)
  Yoshioka H, Nakano M, Minamizaki T, Kozai K, Yoshiko Y
- Organizer
  The American Society of Bone and Mineral Research 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] Single-cell RNA sequencing provides molecular dissection of osteoblasts and their adipogenic potential.2017
- Author(s)
  Nakano M, Yoshioka H, Okita S, Tanimoto K, Kozai K, Minamizaki T, Yoshiko Y
- Organizer
  2017 Annual meeting of the American Society for Bone and Mineral Research.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] Single-cell RNA-sequencing shows the adipogenic potential in osteoblasts.2017
- Author(s)
  Okita S, Yoshioka H, Minamizaki T, Tanimoto K, Yoshiko Y
- Organizer
  2017 ANZBMS-IFMRS Joint Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] シングルセルRNA-seqによる骨芽細胞の多様性と脂肪細胞分化能の解析2017
- Author(s)
  沖田紗季，吉岡広陽，南崎朋子，吉子裕二
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11613
[Presentation] Osteoblasts inhibit osteoclast formation by targeting Prdm1 via the mechanism underlying matrix vesicle-mediated transfer of miR-125b.2016
- Author(s)
  Irie Y, Minamizaki T, Ahmed F, Nakao Y, Yoshioka H, Tanimoto K, Kozai K, Yoshiko Y
- Organizer
  The American Society of Bone and Mineral Research 2016 Annual Meeting
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Histomorphometric analysis of Klotho-deficient mice by nano-CT.2016
- Author(s)
  Ahmed F，Minamizaki T，Yoshioka H，Yoshiko Y
- Organizer
  日本解剖学会第71回中国・四国支部学術集会
- Place of Presentation
  岡山
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] 骨芽細胞は基質小胞を介してmiR-125bを輸送し，Prdm1を標的として破骨細胞の形成を抑制する2016
- Author(s)
  入江泰正，南崎朋子，中尾裕子，Faisal Ahmed，吉岡広陽，香西克之，竹井悠一郎，吉子裕二
- Organizer
  第34回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] MicroRNA-125b in bone matrix plays a crucial role in osteoblast-osteoclast communication.2016
- Author(s)
  Minamizaki T, Takei Y, Nakao Y, Irie Y, Yoshioka H, Tanimoto K, Kozai K, Yoshiko Y
- Organizer
  43rd Annual European Calcified Tissue Society Congress
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Matrix vesicle miR-125b suppress osteoclast formation by targeting Prdm1.2016
- Author(s)
  Irie Y, Minamizaki T, Nakao Y, Ahmed F, Yoshioka H, Kozai K, Tanimoto K, Yoshiko Y
- Organizer
  Annual Meetings of the Endocrine Society of Australia and Society for Reproductive Biology and Australia and New Zealand Bone and Mineral Society 2016
- Place of Presentation
  Queensland, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] シングルセルRNA-seqによる骨芽細胞の多様性の解析2016
- Author(s)
  沖田紗季，吉岡広陽，南崎朋子，谷本幸太郎，吉子裕二
- Organizer
  日本解剖学会第71回中国・四国支部学術集会
- Place of Presentation
  岡山
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] 骨芽細胞の多様性と脂肪細胞への分化転換2016
- Author(s)
  沖田紗季，吉岡広陽，南崎朋子，谷本幸太郎，吉子裕二
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Matrix Vesicles Mediate the Cell-to-Cell Transmission of MicroRNA-125b as an Inhibitor of Osteoclastic Bone Resorption.2015
- Author(s)
  Takei Y, Nakao Y, Minamizaki T, Irie Y, Ahmed F, Yoshioka H, Niida S, Tanimoto K, Yoshiko Y
- Organizer
  The American Society for Bone and Mineral Research 2015 Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] A Novel isoform of FGFR2 Modulates FGF10-FGFR Signaling in Osteochondrogenesis.2015
- Author(s)
  Yoshioka H, Kagawa K, Okita S, Kuremoto K, Takei Y, Minamizaki T, Tanimoto K, Tsuga K, Yoshiko Y
- Organizer
  6th Hiroshima Conference on Education and Science in Dentistry
- Place of Presentation
  広島国際会議場
- Year and Date
  2015-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Bone-derived miRNA as a mediator of cell-cell communication.2015
- Author(s)
  Takei Y, Minamizaki T, Yoshioka H, Yoshiko Y
- Organizer
  6th Hiroshima Conference on Education and Science in Dentistry
- Place of Presentation
  広島国際会議場
- Year and Date
  2015-10-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Newly Identified FGFR2 Isoform Modulates FGF10-FGFR Signaling During Osteochondrogenesis.2015
- Author(s)
  Kagawa K, Yoshioka H, Okita S, Kuremoto K, Takei Y, Minamizaki T, Tanimoto K, Tsuga K, Yoshiko Y
- Organizer
  The American Society for Bone and Mineral Research 2015 Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] MicroRNAs Involved in Bone Metabolism Are Transported into Matrix Vesicles during Bone Formation.2015
- Author(s)
  Nakao Y, Takei Y, Minamizaki T, Yoshioka H, Ahmed F, Tanimoto K, Niida S, Yoshiko Y
- Organizer
  The American Society for Bone and Mineral Research 2015 Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462785
[Presentation] Imaging Mass Spectrometry-based Molecular Histology of Bone Shows the Implication of MEPE-ASARM for the Klotho-Deficient Phenotype.2013
- Author(s)
  Fujino Y, Minamizaki T, Sakurai K, Irie Y, Yoshioka H, Takei Y, Kozai K, Okada M, Yoshiko Y.
- Organizer
  The American Society for Bone and Mineral Research 2013 Annual Meeting
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] マウス歯胚発生過程におけるDNAメチル化酵素Dnmt1の役割2013
- Author(s)
  大西　梓，吉岡　広陽，南崎　朋子，吉子　裕二
- Organizer
  第118回　日本解剖学会総会・全国学術集会
- Place of Presentation
  香川県高松市
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Imaging mass spectrometry-based molecular histology of bone shows the implication of MEPE-ASARM for the Klotho-deficient phenotype2013
- Author(s)
  Fujino Y, Minamizaki T, Sakurai K, Irie Y, Yoshioka H, Takei Y, Kozai K, Okada M, Yoshiko Y
- Organizer
  The American Society for Bone and Mineral Research 2013 Annual Meeting
- Place of Presentation
  Baltimore, USA
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Soluble Klotho does not rescue but rather exaggerates skeletal defects in Klotho-deficient mice2013
- Author(s)
  Minamizaki T, Konishi Y, Sakurai K, Yoshioka H, Kozai K, Yoshiko Y
- Organizer
  5th Hiroshima Conference on Education and Science in Dentistry
- Place of Presentation
  Hiroshima
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] マウス歯胚発生過程におけるDNA メチル化酵素Dnmt1 の役割2013
- Author(s)
  大西梓, 吉岡広陽, 南崎朋子, 吉子裕二
- Organizer
  第118回日本解剖学会総会・学術集会
- Place of Presentation
  高松
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Soluble Klotho does not rescue but rather exaggerates skeletal defects in Klotho-deficient mice2013
- Author(s)
  Minamizaki T, Konishi Y, Sakurai K, Yoshioka H, Kozai K, Yoshiko Y
- Organizer
  2nd Joint Meeting of International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] マウス歯胚発生過程におけるエピジェネティクス制御機構の解明2013
- Author(s)
  吉岡広陽, 南崎朋子, 吉子裕二
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山
- Year and Date
  2013-09-21
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Soluble Klotho does not rescue but rather exaggerates skeletal defects in klotho-deficient mice.2013
- Author(s)
  Minamizaki T, Konishi Y, Sakurai K, Yoshioka H, Kozai K, Yoshiko Y.
- Organizer
  2nd Joint Meeting of International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Transient but not Constitutive Activation of ERK Is Necessary for the Unique Action of FGF23 in Bone2012
- Author(s)
  Minamizaki Tomoko, Konishi Yukiko, Yoshioka Hirotaka, Kozai Katsuyuki, Yoshiko Yuji
- Organizer
  The American Society for Bone and Mineral Research 2012 Annual Meeting
- Place of Presentation
  Minneapolis, U.S.A.
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] Transient but not Constitutive Activation of ERK Is Necessary for the Unique Action of FGF23 in Bone.2012
- Author(s)
  Tomoko Minamizaki, Yukiko Konishi, Hirotaka Yoshioka, Kozai Kozai, Yuji Yoshiko
- Organizer
  The American Society for Bone and Mineral Research 2012 Annual Meeting
- Place of Presentation
  Minneapolis, USA
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] Transient but not constitutive activation of ERK is necessary for the unique action of FGF23 in bone2012
- Author(s)
  Minamizaki T, Konishi Y, Yoshioka H, Kozai K, Yoshiko Y
- Organizer
  The 34th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Minneapolis, USA
- Data Source
  KAKENHI-PROJECT-24791962
[Presentation] Phosphate Regulates Fibromodulin Expression Tlarough the ERK Pathway in Ameloblasts2012
- Author(s)
  吉岡広陽
- Organizer
  41^<st> Annual Meeting of the American Association for Dental Research
- Place of Presentation
  アメリカ合衆国フロリダ州タンパ
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Phosphate Regulates Fibromodulin Expression Through theERK Pathway in Ameloblasts2012
- Author(s)
  Yoshioka H, Yoshiko Y, Irie Y, Minamizaki T, Kato Y, Sugiyama T, Maeda N
- Organizer
  The 41^<st> Annual Meeting of the AmericanAssociation for Dental Research
- Place of Presentation
  Tampa, FL, USA
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Phosphate Regulates Fibromodulin Expression Through the ERK Pathway in Ameloblasts2012
- Author(s)
  Yoshioka Hirotaka, Yoshiko Yuji, Irie Yasumasa, Minamizaki Tomoko, Kato Yukio, Sugiyama Toshihiro, Maeda Norihiko
- Organizer
  The 41st Annual Meeting of the American Association for Dental Research
- Place of Presentation
  Tampa, U.S.A
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] 細胞外リン酸は ERK1/2 のシグナルを介してエナメル芽細胞における Fibromodulin 遺伝子の発現を抑制する2011
- Author(s)
  入江泰正,吉岡広陽,吉子裕二,南崎朋子,加藤幸夫,前田憲彦
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] Shimizu A, AubinJ, Maeda N. MEPE-Derived Phosphorylated ASARM Is Involved inFGF23/ soluble Klotho-DependentHypomineralization2011
- Author(s)
  Konishi Y, Yoshiko Y, Minamizaki T, Yoshioka H, Maeda M, Shimizu A, AubinJ, Maeda N
- Organizer
  The 33rd AnnualMeeting of the American Society forBone and Mineral Research
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] 細胞外リン酸はERK1/ 2シグナルを介してエナメル芽細胞におけるFibromodulin遺伝子の発現を抑制する2011
- Author(s)
  入江泰正, 吉岡広陽, 吉子裕二, 南崎朋子, 加藤幸夫, 前田憲彦
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] MEPE-derived phosphorylated ASARM is involved in FGF23/soluble Klotho-dependent hypomineralization2011
- Author(s)
  Konishi Yukiko, Minamizaki Tomoko, Yoshiko Yuji, Yoshioka Hirotaka, Kozai Katsuyuki, Jane E. Aubin, Maeda Norihiko
- Organizer
  The American Society for Bone and Mineral Research 2011 Annual Meeting
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] MEPE-associated phosphorylated ASARM is a potential target to facilitate bone mineralization2011
- Author(s)
  Mohri Maya, Yoshiko Yuji, Minamizaki Tomoko, Yoshioka Hirotaka, Maeda Norihiko
- Organizer
  4th Hiroshima Conference on Education and Science in Dentistry
- Place of Presentation
  Hiroshima
- Year and Date
  2011-10-10
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] 骨の石灰化調節に関わる可溶化型Klotho-FGF23 基軸2011
- Author(s)
  南崎朋子、吉子裕二、吉岡広陽、前田憲彦
- Organizer
  日本解剖学会第66回中国・四国支部学術集会
- Place of Presentation
  徳島
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] FGF シグナルによる石灰化調節:FGF23-Phex 経路を中心として2011
- Author(s)
  南崎朋子,吉子裕二,小西有希子,吉岡広陽,香西克之,前田憲彦
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] MEPE 由来リン酸化 ASARM と Phex は FGF23/可溶型Klotho による石灰化の負の調節系と関連する2011
- Author(s)
  小西有希子,吉子裕二,南崎朋子,吉岡広陽,香西克之,前田憲彦
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-23792105
[Presentation] FGFシグナルによる石灰化調節:FGF23-Phex経路を中心として2011
- Author(s)
  南崎朋子, 吉子裕二, 小西有希子, 吉岡広陽, 香西克之, 前田憲彦
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] MEPE由来リン酸化ASARMとPhexはFGF23/可溶型Klothoによる石灰化の負の調節系と関連する2011
- Author(s)
  小西有希子, 吉子裕二, 南崎朋子, 吉岡広陽, 香西克之, 前田憲彦
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Overexpression of the Type III Sodium-dependent Phosphate Transporter Pit1 Markedly Perturbs Enamel Formation during Tooth Development2010
- Author(s)
  Yoshioka H, 他
- Organizer
  The American Society for Bone and Mineral Research 2010 Annual Meeting
- Place of Presentation
  カナダ国トロント市
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] Soluble Klotho Acts as a Coactivator of FGF23 in Bone but not in Kidney to Regulate Mineralization.2010
- Author(s)
  Minamizaki T, Yoshiko Y, Konishi Y、Yoshioka H, et al.
- Organizer
  The 32nd Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Toronto
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] 老化関連タンパクKlothoによる骨の石灰化調節機構2010
- Author(s)
  小西有希子, 吉子裕二, 南崎朋子, 北畠聖子, 吉岡広陽, 香西克之, 前田憲彦
- Organizer
  第43回広島大学歯学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] 可溶型Klothoは骨におけるFGF23の作用発現にリクルートされる2010
- Author(s)
  南崎朋子, 吉子裕二, 吉岡広陽, 前田憲彦
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は歯のエナメル質形成に影響し, 骨・ミネラル代謝異常の発症とともに増悪する2010
- Author(s)
  錦織亜矢, 吉岡広陽, 吉子裕二, 南崎朋子, 他
- Organizer
  第52回歯科基礎医学会学術大会
- Place of Presentation
  東京
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は骨・ミネラル代謝に先行して歯のエナメル質形成に障害をきたす2010
- Author(s)
  吉岡広陽, 吉子裕二, 南崎朋子, 他
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は骨・ミネラル代謝に先行して歯のエナメル質形成に障害をきたす2010
- Author(s)
  吉岡広陽, 他
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は歯のエナメル質形成に影響し,骨・ミネラル代謝異常の発症とともに増悪する2010
- Author(s)
  錦織亜矢, 吉岡広陽, 吉子裕二, 南崎朋子, 前田憲彦
- Organizer
  第52回歯科基礎医学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Overexpression of the type III sodium-dependent phosphate transporter Pit1 markedly perturbs enamel formation during tooth development2010
- Author(s)
  吉岡広陽
- Organizer
  2010 Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  カナダオンタリオ州トロント
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Overexpression of the type III sodium-dependent phosphate transporter Pit1 markedly perturbs enamel formation during tooth development.2010
- Author(s)
  Yoshioka H, Yoshiko Y, Minamizaki T, et al.
- Organizer
  The 32nd Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Toronto
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は骨・ミネラル代謝に先行して歯のエナメル質形成に障害をきたす2010
- Author(s)
  吉岡広陽
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  東京都新宿区
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] 老化関連タンパクKlothoによる骨の石灰化調節機構2010
- Author(s)
  小西有希子, 吉子裕二, 南崎朋子, 吉岡広陽, 他
- Organizer
  第43回広島大学歯学会総会
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型ナトリウム依存性リン酸トランスポーターPit1の過剰発現は骨・ミネラル代謝に先行して歯のエナメル質形成に障害をきたす2010
- Author(s)
  吉岡広陽, 吉子裕二, 南崎朋子, 鈴木敦詞, 伊藤光泰, 前田憲彦
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Overexpression of the type IIIsodium-dependent phosphatetransporter Pit1 markedly perturbsenamel formation during toothdevelopment2010
- Author(s)
  Yoshioka H, Yoshiko Y, Minamizaki T, Suzuki A, Itoh M, Maeda N
- Organizer
  The32nd Annual Meetingof the American Society for Bone andMineral Research
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] Soluble Klotho Acts as a Coactivator of FGF23 in Bone but notin Kidney to Regulate Mineralization2010
- Author(s)
  Minamizaki T, Yoshiko Y, Konishi Y, Yoshioka H, Kozai K, Aubin JE, MaedaN
- Organizer
  The32nd Annual Meeting of theAmerican Society for Bone and MineralResearch
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-22791768
[Presentation] III型Na/Pi共輸送担体Pit1過剰発現ラットはエナメル質の形成不全をきたす2009
- Author(s)
  吉岡広陽
- Organizer
  歯科基礎医学会
- Place of Presentation
  新潟市
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21890156
[Presentation] III型Na/Pi共輸送担体Pit1過剰発現ラットはエナメル質の石灰化不全を来す2009
- Author(s)
  小間義朗, 吉岡広陽, 吉子裕二, 南崎朋子, 他
- Organizer
  第42回広島大学歯学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型Na/Pi共輸送担体Pit1過剰発現ラットはエナメル質形成不全を来す2009
- Author(s)
  吉岡広陽, 他
- Organizer
  第27回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型Na/Pi共輸送担体Pit1過剰発現ラットはエナメル質の形成不全をきたす2009
- Author(s)
  吉岡広陽, 吉子裕二, 南崎朋子, 前田憲彦
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] PTHと活性型ビタミンD_3は骨芽細胞におけるFGF23の発現とシグナル伝達に相反的に関与し,基質石灰化を調節する2009
- Author(s)
  南崎朋子, 吉子裕二, 吉岡広陽, 前田憲彦
- Organizer
  第27回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] A Parathyroid Hormone-1α,25-dihydroxy-vitamin D_3-FGF23 Loop Regulating Bone Mineralization in Cultured Rat Calvaria Osteoblasts.2009
- Author(s)
  Minamizaki T, Yoshiko Y, Yoshioka H, Aubin JE, Maeda N
- Organizer
  The 31st Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Denver, USA
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] III型Na/Pi共輸送担体 Pit1過剰発現ラットはエナメル質の形成不全を来す2009
- Author(s)
  吉岡広陽
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪市
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-21890156
[Presentation] III型Na/Pi共輸送担体Pit1過剰発現ラットはエナメル質の形成不全を来す2009
- Author(s)
  吉岡広陽, 吉子裕二, 南崎朋子, 鈴木敦詞, 伊藤光泰, 前田憲彦
- Organizer
  第27回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20592139
[Presentation] マウス歯胚発生過程におけるエピジェネティクス制御機構の解明
- Author(s)
  吉岡広陽，南崎朋子，吉子裕二
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山県岡山市
- Data Source
  KAKENHI-PROJECT-24791962

1. YOSHIKO Yuji (20263709)

# of Collaborated Projects: 4 results

# of Collaborated Products: 48 results
2. MINAMIZAKI Tomoko (30452593)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
3. UCHIDA Soshi (60330990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KOZAI Katsuyuki (10178212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. NIIDA Shunpei (10137630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TAKEI Yuichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. HIYAMA Shinji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAGAWA Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. OKITA Saki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. NAKANO Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 宮地孝明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshioka Hirotaka 吉岡 広陽

吉岡 広陽 ヨシオカ ヒロタカ

YOSHIOKA Hirotaka 吉岡 広陽

Research Projects

Research Products

Co-Researchers

一細胞遺伝子発現プロファイルに基づく骨芽細胞系譜の分化多様性機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

単一細胞解析による骨芽細胞の運命制御機構の解明と新規骨形成促進剤の標的分子探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of bone regeneration strategies by controlling the epigenetic state of bone lining cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of tooth morphogenesis from the aspect of local regulation of phosphate metabolism: An epigenomic approach.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A basic study of de novo function of PTH in mineral metabolism disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tooth morphogenesis and the regulation of phosphate homeostasis : basic and preclinical studies of tooth hypoplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リン酸代謝を分子基盤とした歯の石灰化不全の解析と実験的治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A basic study on FGF23 for molecular targeted therapy of bone/tooth diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble Klotho causes hypomineralization in Klotho-deficient mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative proteome analysis of wild-type and klotho-knockout mouse kidneys using a combination of MALDI-IMS and LC-MS/MS.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imaging and mapping of mouse bone using MALDI-imaging mass spectrometry.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The dynamics of DNA methylation and hydroxymethylation during amelogenesis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sequence-specific promoter elements regulate temporal-specific changes in chromatin required for testis-specific activation of the Pgk2 gene2013

Yoshioka Hirotaka 吉岡広陽

吉岡広陽ヨシオカヒロタカ

YOSHIOKA Hirotaka 吉岡広陽