Kanaseki Takayuki 金関貴幸

… Alternative Names

KANASEKI Takayuki 金関貴幸

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Researcher Number	50531266
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 札幌医科大学, 医学部, 講師 2014 – 2015: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 49020:Human pathology-related / Basic Section 55040:Respiratory surgery-related / Human pathology
Keywords	Principal Investigator 腫瘍抗原 / 腫瘍免疫 / 免疫監視 / T細胞 / HLA / MHC / がん免疫治療 / ネオ抗原 / 免疫原性 / CD8 T細胞 … More / ネオアンチゲン / Non-coding RNA / Cancer Immunotherapy / Antigen Processing / Cancer Antigen / プロテオゲノミクス / がん抗原 / ノンコーディングRNA / 免疫治療 / 抗原 / がん免疫療法 / Tapasin / CTL / tapasin / HLAクラスI / 抗原提示 / 免疫逃避 … More Except Principal Investigator 免疫チェックポイント阻害剤 / ネオアンチゲン / プロテオゲノミクス / 口腔がん / 免疫療法 / HLAリガンドーム解析 / CD8+T細胞 / ネオ抗原 / 次世代シーケンサー / 免疫治療 / CTL / 肺がん / 細胞・組織 / 分子生物学 / 免疫学 / 腫瘍学 / 病理学 / Tumor antigen / 免疫病理診断 / 腫瘍免疫 / Immunohistochemistry / Immune response / Tumor immune escape / Single cell analysis / Cancer stem cell / Tumor microenvironment / 免疫病理バイオマーカー / 単細胞遺伝子発現解析 / がん免疫応答 / がん組織微小環境 / 腫瘍組織微小環境 / がん抗原 / シングルセル遺伝子解析 / がん幹細胞 / 単細胞遺伝子解析 / がん最適化治療 / バイオマーカー / 免疫組織染色 / がん免疫療法 / T細胞抗原受容体 / 腫瘍微小環境 Less

新しいネオ抗原検出技術による腫瘍特異的CD4+T細胞の機能解析とがん治療応用Principal Investigator
- Principal Investigator
  
  金関貴幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
ネオ抗原特異的T細胞の分子変化に基づく新規免疫チェックポイント分子の探索
- Principal Investigator
  
  時田芹奈
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
Identification of oral cancer neoantigens with proteogenomics HLA ligandome analysis
- Principal Investigator
  
  宮本昇
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Sapporo Medical University
Development of immunotherapies targeting neoantigens against immune checkpoint inhibitor-resistant lung tumors
- Principal Investigator
  
  Nagaoka Koji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  The University of Tokyo
Prediction of immunogenic neoantigens based on pHLA structurePrincipal Investigator
- Principal Investigator
  
  KANASEKI Takayuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Sapporo Medical University
HLA presentation mechanisms of long non-coding RNA-derived cancer antigensPrincipal Investigator
- Principal Investigator
  
  KANASEKI Takayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Sapporo Medical University
Basic research on the immunohistological categorization of tumor microenvironment
- Principal Investigator
  
  TORIGOE Toshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Loss of tapasin limits HLA class I antigen processing and results in escape from CTL responses to cancer cellsPrincipal Investigator
- Principal Investigator
  
  KANASEKI Takayuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Sapporo Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy.2023
- Author(s)
  Sho Miyamoto, Yoshihiko Hirohashi, Rena Morita, Akihiro Miyazaki, Kazuhiro Ogi, Takayuki Kanaseki, Kentaro Ide, Jumpei Shirakawa, Tomohide Tsukahara, Aiko Murai, Takashi Sasaya, Kazushige Koike, Shinichiro Kina, Toshihiro Kawano, Takahiro Goto, Edward Hosea Ntege, Yusuke Shimizu, Toshihiko Torigoe
- Journal Title
  
  Cancer Sci.
  
  Volume: 114(9) Pages: 3496-3508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09337
[Journal Article] Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry2022
- Author(s)
  Kato Koji、Nakatsugawa Munehide、Tokita Serina、Hirohashi Yoshihiko、Kubo Terufumi、Tsukahara Tomohide、Murata Kenji、Chiba Hirofumi、Takahashi Hiroki、Hirano Naoto、Kanaseki Takayuki、Torigoe Toshihiko
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: 12 Pages: 2856-2865
- DOI
  10.4049/jimmunol.2100717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-21K18257
[Journal Article] Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer.2022
- Author(s)
  Someya M, Tokita S, Kanaseki T, Kitagawa M, Hasegawa T, Tsuchiya T, Fukushima Y, Gocho T, Kozuka Y, Mafune S, Ikeuchi Y, Takahashi M, Moniwa K, Matsuo K, Hasegawa T, Torigoe T, Sakata KI.
- Journal Title
  
  Cancer Sci.
  
  Volume: 113(12) Issue: 12 Pages: 4394-4400
- DOI
  10.1111/cas.15566
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07680, KAKENHI-PROJECT-21K15787, KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-19K17174, KAKENHI-PROJECT-20K16764, KAKENHI-PROJECT-21K18257
[Journal Article] Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy2022
- Author(s)
  Koji Nagaoka, Changbo Sun, Yukari Kobayashi, Takayuki Kanaseki, Serina Tokita, Toshihiro Komatsu, Kazuhiro Maejima, Junichiro Futami, Sachiyo Nomura, Keiko Udaka, Hidewaki Nakagawa, Toshihiko Torigoe, Kazuhiro Kakimi
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 1 Pages: 106-106
- DOI
  10.3390/cancers14010106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09161, KAKENHI-PROJECT-20KK0174, KAKENHI-PROJECT-21K18257, KAKENHI-PROJECT-19K07775
[Journal Article] CD8+ T?cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA <i>PVT1</i>2021
- Author(s)
  Kikuchi Yasuhiro、Tokita Serina、Hirama Tomomi、Kochin Vitaly、Nakatsugawa Munehide、Shinkawa Tomoyo、Hirohashi Yoshihiko、Tsukahara Tomohide、Hata Fumitake、Takemasa Ichiro、Sato Noriyuki、Kanaseki Takayuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 9 Issue: 11 Pages: 1342-1353
- DOI
  10.1158/2326-6066.cir-20-0964
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-21K08152, KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-21K18257
[Journal Article] Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity2021
- Author(s)
  Ito Koyu、Kanaseki Takayuki、Tokita Serina、Torigoe Toshihiko、Hirasawa Noriyasu、Ogasawara Kouetsu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 736936-736936
- DOI
  10.3389/fimmu.2021.736936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-19H03835, KAKENHI-PROJECT-21K18257, KAKENHI-PROJECT-21H00854
[Journal Article] Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair deficient colorectal cancer tissue2021
- Author(s)
  Hirama Tomomi、Tokita Serina、Nakatsugawa Munehide、Murata Kenji、Nannya Yasuhito、Matsuo Kazuhiko、Inoko Hidetoshi、Hirohashi Yoshihiko、Hashimoto Shinichi、Ogawa Seishi、Takemasa Ichiro、Sato Noriyuki、Hata Fumitake、Kanaseki Takayuki、Torigoe Toshihiko
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 14 Pages: 146356-146356
- DOI
  10.1172/jci.insight.146356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-21K18257
[Journal Article] Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions2021
- Author(s)
  Shinkawa Tomoyo、Tokita Serina、Nakatsugawa Munehide、Kikuchi Yasuhiro、Kanaseki Takayuki、Torigoe Toshihiko
- Journal Title
  
  OncoImmunology
  
  Volume: 10 Issue: 1 Pages: 1870062-1870062
- DOI
  10.1080/2162402x.2020.1870062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-21K18257
[Journal Article] Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma2020
- Author(s)
  Tsukahara, T. Watanabe, K. Murata, K. Takahashi, A. Mizushima, E. Shibayama, Y. Kameshima, H. Hatae, R. Ohno, Y. Kawahara, R. Murai, A. Nakatsugawa, M. Kubo, T. Kanaseki, T. Hirohashi, Y. Terui, T. Asanuma, H. Hasegawa, T. Sato, N. Torigoe, T.
- Journal Title
  
  Cancer immunology immunotherapy
  
  Volume: 69 Issue: 2 Pages: 189-197
- DOI
  10.1007/s00262-019-02455-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-18K19458
[Journal Article] Proteogenomic discovery of cancer antigens: Neoantigens and beyond2019
- Author(s)
  Kanaseki, T. Tokita, S. Torigoe, T.
- Journal Title
  
  Pathology international
  
  Volume: 69 Issue: 9 Pages: 511-518
- DOI
  10.1111/pin.12841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-17H01540
[Journal Article] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.2019
- Author(s)
  Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2386-2395
- DOI
  10.1111/cas.14099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.2019
- Author(s)
  Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 8 Pages: 2378-2385
- DOI
  10.1111/cas.14106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
[Journal Article] Proteogenomics: advances in cancer antigen research2019
- Author(s)
  Kanaseki, T. Torigoe, T.
- Journal Title
  
  Immunological medicine
  
  Volume: 42 Issue: 2 Pages: 65-70
- DOI
  10.1080/25785826.2019.1640500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-19H03490, KAKENHI-PROJECT-17H01540
[Journal Article] Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8(+) T Cell Responses2019
- Author(s)
  Hongo, A. Kanaseki, T. Tokita, S. Kochin, V. Miyamoto, S. Hashino, Y. Codd, A. Kawai, N. Nakatsugawa, M. Hirohashi, Y. Sato, N. Torigoe, T.
- Journal Title
  
  Journal of immunology
  
  Volume: 202 Issue: 10 Pages: 2849-2855
- DOI
  10.4049/jimmunol.1900029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-17H01540
[Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019
- Author(s)
  Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 36-46
- DOI
  10.1111/cas.14229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807
[Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019
- Author(s)
  Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
- Journal Title
  
  Exp Mol Pathol
  
  Volume: 106 Pages: 78-88
- DOI
  10.1016/j.yexmp.2018.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PLANNED-17H06399, KAKENHI-PROJECT-16H05451, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
[Journal Article] ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD2019
- Author(s)
  Kawai Noriko、Hirohashi Yoshihiko、Ebihara Yuma、Saito Takuma、Murai Aiko、Saito Takahiro、Shirosaki Tomohide、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Shichinohe Toshiaki、Li Liming、Hirano Satoshi、Torigoe Toshihiko
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 5 Pages: 0216503-0216503
- DOI
  10.1371/journal.pone.0216503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11285, KAKENHI-PROJECT-19K16822, KAKENHI-PROJECT-17H01540
[Journal Article] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer2018
- Author(s)
  Miyamoto Sho、Kochin Vitaly、Kanaseki Takayuki、Hongo Ayumi、Tokita Serina、Kikuchi Yasuhiro、Takaya Akari、Hirohashi Yoshihiko、Tsukahara Tomohide、Terui Takeshi、Ishitani Kunihiko、Hata Fumitake、Takemasa Ichiro、Miyazaki Akihiro、Hiratsuka Hiroyoshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 6 Issue: 3 Pages: 358-369
- DOI
  10.1158/2326-6066.cir-17-0518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11729, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018
- Author(s)
  Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 741-750
- DOI
  10.1111/cas.13501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
[Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018
- Author(s)
  Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 2 Pages: 158-168
- DOI
  10.1038/s41374-018-0132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K21249, KAKENHI-PROJECT-17H01540
[Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018
- Author(s)
  Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 40-51
- DOI
  10.1111/cas.13854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.2018
- Author(s)
  Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 67 Issue: 10 Pages: 1603-1609
- DOI
  10.1007/s00262-018-2217-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer.2017
- Author(s)
  Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y.
- Journal Title
  
  Oncotarget
  
  Volume: 2016 Issue: 15 Pages: 24706-24718
- DOI
  10.18632/oncotarget.14960
- NAID
  120006219870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
[Journal Article] Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma2017
- Author(s)
  Okamoto, J. Y. Miyazaki, A. Kobayashi, J. I. Miyamoto, S. Sasaki, T. Kanaseki, T. Hirohashi, Y. Torigoe, T. Hiratsuka, H.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 9 Pages: 4889-4897
- DOI
  10.21873/anticanres.11898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017
- Author(s)
  Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: 0171460-0171460
- DOI
  10.1371/journal.pone.0171460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy2017
- Author(s)
  Miyamoto, S. Kanaseki, T. Hirohashi, Y. Tsukahara, T. Kikuchi, Y. Sato, N. Torigoe, T.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 40 Issue: 1 Pages: 40-47
- DOI
  10.2177/jsci.40.40
- NAID
  130005665568
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017
- Author(s)
  Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 485 Issue: 3 Pages: 651-657
- DOI
  10.1016/j.bbrc.2017.02.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017
- Author(s)
  Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1739-1745
- DOI
  10.1111/cas.13319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540
[Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017
- Author(s)
  Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 3 Pages: 1289-1295
- DOI
  10.21873/anticanres.11446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen- specific CTL recognition2017
- Author(s)
  Yosuke Shionoya, Takayuki Kanaseki, Sho Miyamoto, et al.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 2 Pages: 1274476-1274476
- DOI
  10.1080/2162402x.2016.1274476
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460581, KAKENHI-PROJECT-17H01540
[Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017
- Author(s)
  Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 19 Pages: 31540-31553
- DOI
  10.18632/oncotarget.16361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.2017
- Author(s)
  Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Yo, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 4 Pages: 1-12
- DOI
  10.1080/2162402x.2017.1293214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08743, KAKENHI-PROJECT-17H01540
[Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017
- Author(s)
  Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 486 Issue: 2 Pages: 232-238
- DOI
  10.1016/j.bbrc.2017.02.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01540
[Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017
- Author(s)
  Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 17 Pages: 28826-28839
- DOI
  10.18632/oncotarget.16259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10599, KAKENHI-PROJECT-17H01540
[Presentation] 新規口腔がん幹細胞特異的抗原とペプチドワクチンへの応用2023
- Author(s)
  宮本昇，笹谷聖，荻和弘，宮﨑晃亘，廣橋良彦，金関貴幸，塚原智英，鳥越俊彦
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K09337
[Presentation] がん免疫療法とプレシジョン医療2022
- Author(s)
  金関　貴幸
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K21528
[Presentation] ネオアンチゲンと免疫チェックポイント阻害剤2021
- Author(s)
  金関貴幸
- Organizer
  日本臨床腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21528
[Presentation] ネオアンチゲンと免疫チェックポイント阻害剤2021
- Author(s)
  金関貴幸
- Organizer
  日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03490
[Presentation] Identification of true neoantigen with anti-tumor activity.2020
- Author(s)
  Koji Nagaoka, Takayuki Kanaseki , Masashi Fujita, Akihiro Hosoi, Yukari Kobayashi, Hidewaki Nakagawa, Toshihiko Torigoe, Kazuhiro Kakimi.
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09161
[Presentation] プロテオゲノミクスによるHLA提示ペプチド解析と非コード領域遺伝子に由来する新しいがん抗原クラスの同定2020
- Author(s)
  金関貴幸
- Organizer
  第24回日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21528
[Presentation] To identify neoantigens relevant to anti-tumor activity is challenging even with NGS-based prediction combined with MHC ligandome profiling2020
- Author(s)
  Koji Nagaoka, Takayuki Kanaseki, Changbo Sun, Akihiro Hosoi, Serina Tokita, Kazuhiro Maejima, Masashi Fujita, Hidewaki Nakagawa, Toshihiko Torigoe, Kazuhiro Kakimi.
- Organizer
  AACR2020　VIRTUAL ANNUALMEEING II
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09161
[Presentation] プロテオゲノミクスによるHLA提示ペプチド解析と非コード領域遺伝子に由来する新しいがん抗原クラスの同定2020
- Author(s)
  金関貴幸
- Organizer
  第24回　日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03490
[Presentation] NGSベースのin silico予測および、MHCリガンドーム解析による抗腫瘍効果を認めるネオアンチゲンの同定2020
- Author(s)
  長岡孝治、金関貴幸、時田芹奈、前嶋和紘、藤田征志、小松利広、孫長博、細井亮宏、宇高恵子、中川英刀、鳥越俊彦、垣見和宏
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K09161
[Presentation] HLA ligandome analysis reveals an antigen processing signature required for HLA class I presentation and CD8+ T cell responses.2019
- Author(s)
  Kanaseki T, Hongo A, Tokita S, Torigoe T.
- Organizer
  CRI-EATI-CIMT-AACR 5th International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Identification of a new type of neoantigen derived from splice peptides2019
- Author(s)
  Kato K, Nakatsugawa M, Kanaseki T, Tokita S, Torigoe T.
- Organizer
  CRI-EATI-CIMT-AACR 5th International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Proteogenomic approach for natural HLA class I ligand peptides of cancer cells.2019
- Author(s)
  Torigoe T, Kanaseki T, Hirohashi Y, Tsukahara T, Nakatsugawa M, Kubo T, Shinkawa T.
- Organizer
  EMBL Conference: Cancer Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] A determinant leading to CD8+ T-cell induction in neoantigens with a single amino acid substitution2019
- Author(s)
  Shinkawa T, Kanaseki T, Tokita S, Torigoe T.
- Organizer
  CRI-EATI-CIMT-AACR 5th International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] 基礎研究視点から考えるネオアンチゲン免疫原性の重要性2019
- Author(s)
  金関貴幸
- Organizer
  日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03490
[Presentation] HLA ligandome analysis reveals an antigen processing signature required for HLA class I presentation and CD8+ T cell responses2019
- Author(s)
  Takayuki Kanaseki
- Organizer
  FIFTH CRI-CIMT-EATI AACR INTERNATIONAL CANCER IMMUNOTHERAPY CONFERENCE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03490
[Presentation] Landscape of natural HLA ligand peptides2017
- Author(s)
  Toshihiko Torigoe, Takayuki Kanaseki, Kochin Vitaly
- Organizer
  第21回日本がん免疫学会総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] Landscape of HLA class I ligand peptides2017
- Author(s)
  Takayuki Kanaseki
- Organizer
  The 36th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] CTL responses against a cancer-stem cell specific antigen, ASB4, effectively prevent colorectal cancer formation2017
- Author(s)
  Kanaseki T, Miyamoto S, Tokita S, Torigoe T.
- Organizer
  THIRD CRI-CIM-EATI-AACR International Cancer Immunotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01540
[Presentation] 非小細胞肺癌におけるtapasin発現低下とCTL免疫逃避のメカニズム2016
- Author(s)
  塩野谷洋輔、金関貴幸
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪市）
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] 悪性腫瘍のimmune-escape variantを標的とした新しいCTL治療の開発2015
- Author(s)
  塩野谷洋輔、金関貴幸、時田芹奈、高橋弘毅、鳥越俊彦、佐藤昇志
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] A novel immunogenic peptide that is naturally processed and presented by HLA-A24 of human colon cancer stem cells2015
- Author(s)
  Sho Miyamoto, Takayuki Kanaseki, Akari Takahashi, Vitaly Kochin, Yoshihiko Hirohashi, Toshihiko Torigoe, Noriyuki Sato
- Organizer
  がん免疫療法・マクロファージ国際会議2015
- Place of Presentation
  東京大学伊藤国際学術センター（東京都文京区）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] 腫瘍のCTL免疫逃避バリアントに対する新しい治療戦略2015
- Author(s)
  塩野谷洋輔、金関貴幸、時田芹奈、高橋弘毅、鳥越俊彦、佐藤昇志
- Organizer
  第13回日本臨床腫瘍学会学術集会
- Place of Presentation
  ロイトン札幌（札幌市）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] ヒトがん幹細胞を標的としたHLA-A2ナチュラルペプタイドの探索2015
- Author(s)
  濱田早紀、金関貴幸、鳥越俊彦、他
- Organizer
  第61回日本病理学会秋期特別総会
- Place of Presentation
  東京大学安田講堂（東京都文京区）
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] ETAS摂取は抗がん剤副作用から正常臓器を保護する2015
- Author(s)
  中山綾子、橋野結子、時田芹奈、浅沼広子、金関貴幸、鳥越俊彦
- Organizer
  第10回臨床ストレス応答学会大会
- Place of Presentation
  東京農工大学140周年記念会館（東京都小金井市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] ヒト細胞におけるHLA-A24リガンドーム解析2015
- Author(s)
  時田芹奈、金関貴幸、鳥越俊彦、他
- Organizer
  第61回日本病理学会秋期特別総会
- Place of Presentation
  東京大学安田講堂（東京都文京区）
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] HLA-A24 peptidomics of cancer and cancer stem cells2014
- Author(s)
  Kochin Vitaly, Takayuki Kanaseki, et al.
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] A new mode of CTL induction secondary to antigen-processing defects in the endoplasmic reticulum2014
- Author(s)
  金関　貴幸、他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26460581
[Presentation] 癌幹細胞のMHCクラスI抗原プロセシング2014
- Author(s)
  植木　美渚、金関　貴幸、他
- Organizer
  第60回日本病理学会秋期特別総会
- Place of Presentation
  国立劇場おきなわ（沖縄県浦添市）
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-26460581

1. TORIGOE Toshihiko (20301400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
2. Nagaoka Koji (80649799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 橋本真一 (00313099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 廣橋良彦 (30516901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 塚原智英 (20404634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. 久保輝文 (90580019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 中津川宗秀 (70448596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 垣見和宏 (80273358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 時田芹奈 (60972883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮本昇 (80749565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 宮崎晃亘 (10305237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. MASUMORI Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NANYA Yasuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 水口徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 江森誠人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 小海康夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 北村寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 江藤正俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 染谷正則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 後町俊夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 小塚陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 斉藤豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kanaseki Takayuki 金関 貴幸

KANASEKI Takayuki 金関 貴幸

Research Projects

Research Products

Co-Researchers

新しいネオ抗原検出技術による腫瘍特異的CD4+T細胞の機能解析とがん治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ネオ抗原特異的T細胞の分子変化に基づく新規免疫チェックポイント分子の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of oral cancer neoantigens with proteogenomics HLA ligandome analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of immunotherapies targeting neoantigens against immune checkpoint inhibitor-resistant lung tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of immunogenic neoantigens based on pHLA structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HLA presentation mechanisms of long non-coding RNA-derived cancer antigensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research on the immunohistological categorization of tumor microenvironment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Loss of tapasin limits HLA class I antigen processing and results in escape from CTL responses to cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy.2023

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD8+ T?cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA <i>PVT1</i>2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity2021

Author(s)

Journal Title

Kanaseki Takayuki 金関貴幸

KANASEKI Takayuki 金関貴幸