Hotta Akitsu 堀田秋津

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HOTTA Akitsu 堀田秋津

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Researcher Number	50578002
Other IDs	https://orcid.org/0000-0002-2619-7441
Affiliation (Current)	2026: 京都大学, iPS細胞研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都大学, iPS細胞研究所, 准教授 2021 – 2022: 京都大学, iPS細胞研究所, 講師 2019 – 2020: 京都大学, iPS細胞研究所, 特定拠点講師 2016 – 2017: 京都大学, iPS細胞研究所, 特定拠点講師 2014 – 2015: 京都大学, iPS細胞研究所, 特定拠点助教 … More 2013 – 2015: 京都大学, 学内共同利用施設等, 助教 2014: 京都大学, 助教 2012 – 2014: 京都大学, iPS細胞研究所, 助教 2010 – 2011: 京都大学, iPS細胞研究所, 特定拠点助教 Less
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 43050:Genome biology-related / Medical genome science / Developmental biology / Human genetics Except Principal Investigator Pediatrics / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 38060:Applied molecular and cellular biology-related / Respiratory organ internal medicine
Keywords	Principal Investigator ゲノム編集 / iPS細胞 / 遺伝子治療 / 送達技術 / 細胞外小胞 / DNA損傷修復 / CRISPR-Cas3 / CRISPR-Cas9 / 一塩基置換 / 一塩基変異 … More / 一塩基修復 / 相同組換え / CRISPR / 発現抑制 / 発現抑制制御 / トランスポゾンベクター / shRNAライブラリー / サイレンシング / 遺伝子導入 / 血友病A / 遺伝子導入ベクター … More Except Principal Investigator モノクローナル抗体 / 表現型スクリーニング / 相補性決定領域 / ゲノム編集 / 細胞治療 / 遺伝子治療 / 血友病A / 細胞移植 / 分子進化 / 機能抗体 / ヒト抗体医薬 / 進化工学 / 染色体工学 / Ｗｎｔ/βカテニンシグナル / CRISPR-Cas9 / 免疫グロブリン / ヒト人工染色体 / VHH / R-spondin / ペプチド / 抗体医薬 / 指向性進化 / ペプチド医薬 / Wnt/βカテニンシグナル / ヒト抗体 / 分子細胞呼吸器学 / 疾患モデリング / 肺臓器再生 / iPS細胞 / 分子細胞呼吸学 / 免疫応答 / 自己細胞 / 血友病Ａ / factor Ⅷ / transposon / piggyBack / gene therapy / hemophilia A / 細胞療法 / 遺伝子・細胞治療 / 免疫寛容導入 / 制御性T細胞 / 免疫寛容 / インヒビター / 血友病 Less

Elucidation of CRISPR-Cas3-induced genomic deletion by analysis of proximal factorsPrincipal Investigator
- Principal Investigator
  
  Hotta Akitsu
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Kyoto University
ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム
- Principal Investigator
  
  冨塚一磨
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
宿主小胞形成因子を活用したCRISPR送達法の開発とその応用Principal Investigator
- Principal Investigator
  
  堀田秋津
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyoto University
Development of induciblydiversified antibody-expressing cell library that enables antibody phenotypic screening
- Principal Investigator
  
  TOMIZUKA KAZUMA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases
- Principal Investigator
  
  Michiaki Mishima
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto University
Precise genomic correction by intercellular regulation of genome editing enzymePrincipal Investigator
- Principal Investigator
  
  Hotta Akitsu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Medical genome science
- Research Institution
  Kyoto University
Establishment of the next generation treatment for hemophilia A by autologous cell implantation
- Principal Investigator
  
  Shima Modori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Establishment of immune torelance induction therapy for FVIII inhibitors by subcutaneous implantation of blood outgrowth endothelial cells
- Principal Investigator
  
  MATSUI HIDETO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Novel shRNA library screening to identify key factors that are important in pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  HOTTA Akitsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto University
Development of non-viral vector for gene therapy strategy using iPS cellsPrincipal Investigator
- Principal Investigator
  
  HOTTA Akitsu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Human genetics
- Research Institution
  Kyoto University

[Book] 生物の科学　遺伝　Vol.71 (05)「iPS細胞の遺伝子変異をゲノム編集で修復するー疾患研究と遺伝子治療の最先端」2017
- Author(s)
  堀田秋津
- Publisher
  NTS Inc.
- Data Source
  KAKENHI-PROJECT-15H05581
[Book] 実験医学増刊号　"All About ゲノム編集"2016
- Author(s)
  石田賢太郎, 徐淮耕, 堀田秋津
- Total Pages
  234
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15H05581
[Book] "論文だけではわからないゲノム編集成功の秘訣Q&A"「ヒト人工多能性幹細胞(iPS細胞)でのゲノム編集」2015
- Author(s)
  李紅梅, 堀田秋津箸・山本卓編
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15H05581
[Book] 医学のあゆみ, 患者由来iPS細胞を用いた神経疾患研究2015
- Author(s)
  津下到, 鈴木茂彦, 内藤素子, 堀田秋津, 井上治久
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15H05581
[Book] 病理と臨床,疾患iPS細胞研究を加速する遺伝子改変技術の進歩2015
- Author(s)
  堀田秋津, 石田賢太郎, 佐伯涼太
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15H05581
[Book] "再生医療2015 幹細胞と疾患iPS細胞の研究最前線"「再生医療に向けたゲノム編集技術」2015
- Author(s)
  李紅梅, 佐伯涼太, 堀田秋津箸・岡野栄之, 山中伸弥編
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs2018
- Author(s)
  Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Watanabe A, Hiratani I, Yamada Y, Yamamoto T, Hotta A, Okita K, Masui S
- Journal Title
  
  Nat Commun.
  
  Volume: 9 Issue: 1 Pages: 1387-1387
- DOI
  10.1038/s41467-018-03748-1
- NAID
  120006517799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01222, KAKENHI-PUBLICLY-16H01321, KAKENHI-PROJECT-16H05042, KAKENHI-PROJECT-15H05581, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-17H05045
[Journal Article] Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors2018
- Author(s)
  Oshima Koichi、Watanabe Akira、Nakahata Tatsutoshi、Saito Megumu K. et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 497 Issue: 2 Pages: 719-725
- DOI
  10.1016/j.bbrc.2018.02.139
- NAID
  120006466601
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0108, KAKENHI-PROJECT-17K12900, KAKENHI-PROJECT-16H05194, KAKENHI-PROJECT-15H05581, KAKENHI-PROJECT-15J06514, KAKENHI-PROJECT-15K06921, KAKENHI-PROJECT-15K09640, KAKENHI-PROJECT-15K11072, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-17H04233, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-15H04655
[Journal Article] Pluripotent stem cell models of Blau syndrome reveal an IFN-γ?dependent inflammatory response in macrophages2018
- Author(s)
  Takada Sanami、Kambe Naotomo、Kawasaki Yuri、Niwa Akira、Honda-Ozaki Fumiko、Kobayashi Kazuki、Osawa Mitsujiro、Nagahashi Ayako、Semi Katsunori、Hotta Akitsu、Asaka Isao、Yamada Yasuhiro、Nishikomori Ryuta、Heike Toshio、Matsue Hiroyuki、Nakahata Tatsutoshi、Saito Megumu K.
- Journal Title
  
  J ALLERGY CLIN IMMUNOL
  
  Volume: 141 Issue: 1 Pages: 339-349.e11
- DOI
  10.1016/j.jaci.2017.04.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10243, KAKENHI-PROJECT-17K16254, KAKENHI-PROJECT-15H05581
[Journal Article] Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells2018
- Author(s)
  Kentaro Ishida, Huaigeng Xu, Noriko Sasakawa, Mandy Siu Yu Lung, Julia Alexandra Kudryashev, Peter Gee & Akitsu Hotta
- Journal Title
  
  Scientific Reports
  
  Volume: online Issue: 1 Pages: 310-310
- DOI
  10.1038/s41598-017-18568-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15048, KAKENHI-PROJECT-15H05581
[Journal Article] 筋ジストロフィー治療応用を目指したゲノム編集技術の開発動向2017
- Author(s)
  蒔田幸正, 穂積裕幸, 堀田秋津
- Journal Title
  
  Clinical Calcium
  
  Volume: 27 Pages: 391-399
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] Cell-type-specific genome editing with a microRNA-responsive CRISPR?Cas9 switch2017
- Author(s)
  Hirosawa Moe、Fujita Yoshihiko、Parr Callum、Hayashi Karin、Kashida Shunnichi、Hotta Akitsu、Woltjen Knut、Saito Hirohide
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 45 Issue: 13 Pages: e118-e118
- DOI
  10.1093/nar/gkx309
- NAID
  120006306001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05581, KAKENHI-PROJECT-16J10715, KAKENHI-PROJECT-15K13314, KAKENHI-PROJECT-15H05722
[Journal Article] Duchenne型筋ジストロフィーに対するゲノム編集戦略2016
- Author(s)
  徐淮耕, 堀田秋津
- Journal Title
  
  医学のあゆみ
  
  Volume: 259 Pages: 73-79
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] From genomics to gene therapy: induced pluripotent stem cells meet genome editing.2015
- Author(s)
  Hotta A, and Yamanaka S.
- Journal Title
  
  Annu. Rev. Genet.,
  
  Volume: 49 Issue: 1 Pages: 47-70
- DOI
  10.1146/annurev-genet-112414-054926
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] Minimizing off-target mutagenesis risks caused by programmable nucleases.2015
- Author(s)
  Ishida K*, Gee P*, and Hotta A. (*: equal contribution)
- Journal Title
  
  Int. J. Mol. Sci.,
  
  Volume: 16 Issue: 10 Pages: 24751-24771
- DOI
  10.3390/ijms161024751
- NAID
  120005689182
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] Genome editing gene therapy for Duchenne muscular dystrophy.2015
- Author(s)
  Hotta A.
- Journal Title
  
  J. Neuromuscul. Dis.,
  
  Volume: 2 Issue: 4 Pages: 343-355
- DOI
  10.3233/jnd-150116
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system.2015
- Author(s)
  Li HL, Gee P, Ishida K, and Hotta A.
- Journal Title
  
  Methods,
  
  Volume: S1046 Pages: 27-35
- DOI
  10.1016/j.ymeth.2015.10.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05581
[Journal Article] 細胞種変換を支える遺伝子導入技術2014
- Author(s)
  堀田秋津
- Journal Title
  
  細胞
  
  Volume: 46(5) Pages: 220-224
- Data Source
  KAKENHI-PROJECT-24770206
[Journal Article] Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A2014
- Author(s)
  Hideto Matsui, Naoko Fujimoto, Noriko Sasakawa, Yasuhide Ohinata, Midori Shima, Shinya Yamanaka, Mitsuhiko Sugimotom Akitsu Hotta
- Journal Title
  
  PLOS ONE
  
  Volume: 9(8) Issue: 8 Pages: e104957-e104957
- DOI
  10.1371/journal.pone.0104957
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591559, KAKENHI-PROJECT-25293237, KAKENHI-PROJECT-25712030
[Journal Article] iPS細胞の小分子制御2011
- Author(s)
  堀田秋津
- Journal Title
  
  学術の動向
  
  Volume: Vol.16 Pages: 62-65
- NAID
  130001072392
- Data Source
  KAKENHI-PROJECT-22890088
[Journal Article] Constitutive heterochromatin reorganization during somatic cell reprogramming2011
- Author(s)
  Fussner E, Djuric U, Strauss M, Hotta A, Perez-Iratxeta C, Lanner F, Dilworth FJ, Ellis J, Bazett-Jones DP
- Journal Title
  
  EMBO Journal
  
  Volume: Vol.30(9) Pages: 1778-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890088
[Patent] 遺伝子変異導入方法2023
- Inventor(s)
  堀田秋津、石田賢太郎
- Industrial Property Rights Holder
  京都大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] 低抗原性細胞の製造方法2023
- Inventor(s)
  堀田秋津、徐淮耕、金子新、王博
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] ゲノムDNAに欠失を誘導する方法2023
- Inventor(s)
  堀田秋津、奥嵜雄也、徐淮耕、真下知士、吉見一人、ジーピーターデビド、北悠人
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] ゲノムDNAに欠失を誘導する方法2021
- Inventor(s)
  堀田秋津、奥嵜雄也、徐淮耕、真下知士、吉見一人、ジーピーターデビド、北悠人
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-559274
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] 低抗原性細胞の製造方法2020
- Inventor(s)
  堀田秋津、徐淮耕、金子新、王博
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-500578
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] ゲノムDNAに欠失を誘導する方法2018
- Inventor(s)
  堀田秋津、奥嵜雄也、徐淮耕
- Industrial Property Rights Holder
  堀田秋津、奥嵜雄也、徐淮耕
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-231649
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] 低抗原性細胞の製造方法2018
- Inventor(s)
  堀田秋津、徐淮耕、金子新、王博
- Industrial Property Rights Holder
  堀田秋津、徐淮耕、金子新、王博
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-026421
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H05581
[Patent] 部位特異的塩基置換法2017
- Inventor(s)
  堀田秋津、石田賢太郎
- Industrial Property Rights Holder
  堀田秋津、石田賢太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-139268
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] iPS細胞におけるゲノム編集　ーその目的と応用ー2024
- Author(s)
  小島　佑介、堀田　秋津
- Organizer
  日本ゲノム編集学会第９回大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23864
[Presentation] 染色体工学技術の抗体研究への応用(5) 多様化誘導抗体を利用した表現型スクリーニング系による Wnt/βカテニンシグナル促進分子の探索2024
- Author(s)
  上田航輝，円子大夢，橋本七海，櫻井諒一，宇野愛海，冨塚一磨，香月康宏，堀田秋津
- Organizer
  第3回日本抗体学会年会、国内、ポスター発表
- Data Source
  KAKENHI-PROJECT-23K27306
[Presentation] 染色体工学技術の抗体研究への応用（6）ゲノム編集誘導性分子多様化による抗体取得が可能な Mammalian Display システムの構築2024
- Author(s)
  櫻井諒一，橋本七海，宇野愛海，香月康宏，堀田秋津，冨塚一磨
- Organizer
  第3回日本抗体学会年会、国内、ポスター発表
- Data Source
  KAKENHI-PROJECT-23K27306
[Presentation] 染色体工学技術応用（13）：抗体の表現型スクリーニングを可能にする、多様化誘導型抗体発現細胞ライブラリの開発2021
- Author(s)
  橋本七海、笹川航、宇野愛海、里深博幸、香月康宏、堀田秋津、冨塚一磨
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02924
[Presentation] 染色体工学技術応用（14）：機能ペプチドの表現型スクリーニングを行う多様化誘導型発現細胞ライブラリの開発2021
- Author(s)
  円子大夢、奥山優希、橋本七海、宇野愛海、石津由紀、香月康宏、堀田秋津、冨塚一磨
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02924
[Presentation] iPS細胞での効率的なゲノム編集と筋ジストロフィー治療への応用2017
- Author(s)
  堀田秋津
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] Genome Editing Applications for iPS Cells and Duchenne Muscular Dystrophy2017
- Author(s)
  堀田秋津
- Organizer
  International Conference of the Genetics Society of Korea (ICGSK) 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] In vitro disease modeling of alveolar phenotype caused by AP3B1 deficiency using human induced pluripotent stem cells.2017
- Author(s)
  Korogi Y, Gotoh S, Yamamoto Y, Konishi S, Nagasaki T, Sone N, Ikeo S, Matsumoto H, Muro S, Ito I, Asaka I, Hotta A, Hirai T
- Organizer
  Stem Cell Research 15th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02537
[Presentation] Gene therapy strategy for Duchenne muscular dystrophy using iPS cells and CRISPR genome editing2016
- Author(s)
  堀田秋津
- Organizer
  Center for Data-Intensive Biomedicine and Biotecnology Seminar
- Place of Presentation
  Skoltech, Russia
- Year and Date
  2016-10-12
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] CRISPRツールボックスによるヒトゲノム編集効率化2016
- Author(s)
  堀田秋津
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] CRISPR システムにおける in silico オフターゲット配列予想ツール比較2016
- Author(s)
  田中正視, 井福正隆, 藤本直子, 堀田秋津
- Organizer
  第１回日本ゲノム編集学会
- Place of Presentation
  広島国際会議場
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] Genome editing iPS cells by CRISPR-Cas9 for Duchenne muscular dystrophy gene therapy2016
- Author(s)
  堀田秋津
- Organizer
  The 39th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-21
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] iPS細胞での効率的なゲノム編集を目指したCRISPRツールボックス2016
- Author(s)
  堀田秋津
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] iPS細胞での効率的なゲノム編集を目指したCRISPRツールボックス2016
- Author(s)
  堀田秋津
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] Precise control of CRISPR-Cas9 mediated gene editing for correcting mutation of Duchenne muscular dystrophy in iPS Cells2015
- Author(s)
  Hongmei L Li, Norko Sasakawa, Kentaro Ishida, Peter Gee and Akitsu Hotta,
- Organizer
  American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting
- Place of Presentation
  米国ニューオリンズ
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] 疾患iPS細胞における新規遺伝子修復戦略2015
- Author(s)
  堀田秋津
- Organizer
  第39回阿蘇シンポジウム
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル
- Year and Date
  2015-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] Efficient gene correction of Duchunne muscular dystrophy mutation in iPS cells by TALENs and CRISPR-Cas92015
- Author(s)
  堀田秋津
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  Osaka International Convention Center
- Year and Date
  2015-07-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] デュシェンヌ型筋ジストロフィーiPS細胞を用いたゲノム編集遺伝子治療2015
- Author(s)
  堀田秋津
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] 疾患iPS細胞における病原変異遺伝子のゲノム手術2015
- Author(s)
  堀田秋津
- Organizer
  第６２回日本実験動物学会総会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H05581
[Presentation] Long-term phenotypic correction of hemophilia A mice by non-viral piggyBac transposon vector.2015
- Author(s)
  Matsui H, Noda M, Shima M, Hotta A, Sugimoto M.
- Organizer
  International Society on Thrombosis and Haemostasis (ISTH) 2015 Congress
- Place of Presentation
  Toronto, Canada
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Novel gene therapy strategy for hemophilia A by hydrodynamic gene delivery combined with non-viral piggyBac transposon vector in canine model2015
- Author(s)
  Noda M, Matsui H, Matsunari Y, Ochi S, Shima M, Fukuoka Y, Sato T, Anai H, Kichikawa K, Nakayama M, Hotta A, Sugimoto M.
- Organizer
  2015 Annual Meeting of the American Society of Hematology
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Long-term phenotypic correction of hemophilia A by non-viral piggyBac trsposon vector2013
- Author(s)
  Matsui H, Sugimoto M, Shima M, Fujimoto, Hotta A
- Organizer
  The ASGCT 16th Annual Meeting
- Place of Presentation
  Salt Lake City, U.S.A
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Long-term phenotypic correction of hemophilia a by non-viral piggyBac transposon vector2013
- Author(s)
  Hideto Matsui, Mitsuhiko Sugimoto, Midori Shima, Naoko Fujimoto, Akitsu Hotta
- Organizer
  The ASGCT 16th Annual Meeting
- Place of Presentation
  Salt Lake City, U.S.A
- Data Source
  KAKENHI-PROJECT-24591559
[Presentation] トランスポゾン発現抑制を司る因子群のshRNAライブラリーによる全ゲノム規模探索2013
- Author(s)
  堀田秋津、仲埜峻雄、白井紗矢、笹川典子、藤本直子、Sylvie Rival-Gervier、山本卓也、山中伸弥
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-24770206
[Presentation] SITE SPECIFIC GENOME EDITING OF HUMAN INDUCED PLURIPOTENT STEM CELLS BY PNA2012
- Author(s)
  Li. H, Fujimoto. N, Sasakawa. N, Shigi. N, Komiyama. M, Hotta. A, Yamanaka. S
- Organizer
  ISSCR annual meeting
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] GENERATION OF CANINE IPS CELLS AND THEIR CHARACTERISTIC2012
- Author(s)
  Hayakawa. K, Kato. T, Akira. N, Ikeya. M, Otsuka. T, Hotta. A, Toguchida. J
- Organizer
  ISSCR annual meeting
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] EFFICIENT AND STABLE EXPRESSION OF NON-VIRAL VECTORS IN HUMAN IPS CELLS : TOWARDS A GENE TH ERAPY APPROACH FOR HEMOPHILIA2012
- Author(s)
  Hotta. A, Fujimoto. N, Nakano.T, Sasakawa. N, Woltjen. K, Gervier. SR, Matsui. H, Yamanaka. S
- Organizer
  ISSCR annual meeting
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] DERIVATION OF NANOG KNOCK-IN GFP REPORTER IPS CELL LINES USING MEGANUCLEASE-INDUCED HOMOLOGOUS RECOMBINATION2012
- Author(s)
  Duhamel. M, Perillous. S, Epinat. JC, Cedrone. F, Englund. M, Ellerstrom. C, Hyllner. J, Hotta. A, Yamanaka. S, Balbirnie. E, Sourdive. D, Rochon. C
- Organizer
  ISSCR annual meeting
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] GENERATION FUNCTIONAL MYOCYTES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS2012
- Author(s)
  Tanaka. A, Woltjen. K, Hotta. A, Ikeya. M, Shoji. E, Isobe. K, Sakurai. H
- Organizer
  ISSCR annual meeting
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] EFFICIENT AND STABLE EXPRESSION OF NON-VIRAL VECTORS IN HUMAN IPS CELLS : TOWARDS A GENE THERAPY APPROACH FOR HEMOPHILIA2012
- Author(s)
  Hotta A, Fujimoto N, Nakano T, Sasakawa N, Woltjen K, Gervier SR, Matsui H, Yamanaka S
- Organizer
  ISSCR(国際幹細胞学会)
- Place of Presentation
  パシフィコ横浜(掲載確定)
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] iPS細胞が分化万能性を獲得する過程におけるクロマチン高次構造の変化2011
- Author(s)
  堀田秋津
- Organizer
  北陸実験動物研究会
- Place of Presentation
  金沢大学(招待講演)
- Year and Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] Efficient and stable expression of non-viral vectors in human iPS cells : towards a gene therapy approach for hemophilia2010
- Author(s)
  Hotta. A
- Organizer
  Canada Stem Cell Network Annua Scientific Meeting
- Place of Presentation
  Calgary, Canada
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] Efficient and stable expression of non-viral vectors in human iPS cells : towards a gene therapy approach for hemophilia.2010
- Author(s)
  堀田秋津
- Organizer
  Canada Stem Cell Network Annual Scientific Meeting
- Place of Presentation
  カルガリー、カナダ
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-22890088
[Presentation] Establishment of the novel piggyBac transposon vector for the treatment of hemophilia A
- Author(s)
  Hideto Matsui, Mitsuhiko Sugimoto, Midori Shima, Naoko Fujimoto, Akitsu Hotta
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24591559

1. MATSUI HIDETO (00571027)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. TOMIZUKA KAZUMA (40444640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 香月康宏 (90403401)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. Shima Modori (30162663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Michiaki Mishima (60190625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 瀬山邦明 (10226681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 半田知宏 (10432395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平井豊博 (20359805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 金永学 (20456883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐藤篤靖 (30706677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐藤晋 (40378691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊藤功朗 (40447975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 長崎忠雄 (40747862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 小熊毅 (50601324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 後藤慎平 (50747219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 室繁郎 (60344454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 松本久子 (60359809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 小笹裕晃 (80572015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 永井宏樹 (80711605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 陳和夫 (90197640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 浅香勲 (10543639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 谷澤公伸 (20639140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小島佑介 (90896416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 岩崎未央 (10722811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HU HOOI TING

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. WATANABE Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 宮本圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 川崎ゆり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. Gee PeterDavid

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hotta Akitsu 堀田 秋津

HOTTA Akitsu 堀田 秋津

Research Projects

Research Products

Co-Researchers

Elucidation of CRISPR-Cas3-induced genomic deletion by analysis of proximal factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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ゲノム編集誘導性分子多様化による、機能抗体・ペプチド表現型スクリーニングシステム

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宿主小胞形成因子を活用したCRISPR送達法の開発とその応用Principal Investigator

Principal Investigator

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Review Section

Research Institution

Development of induciblydiversified antibody-expressing cell library that enables antibody phenotypic screening

Principal Investigator

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Review Section

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Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases

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Precise genomic correction by intercellular regulation of genome editing enzymePrincipal Investigator

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Establishment of the next generation treatment for hemophilia A by autologous cell implantation

Principal Investigator

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Establishment of immune torelance induction therapy for FVIII inhibitors by subcutaneous implantation of blood outgrowth endothelial cells

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Novel shRNA library screening to identify key factors that are important in pluripotent stem cellsPrincipal Investigator

Principal Investigator

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Development of non-viral vector for gene therapy strategy using iPS cellsPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 生物の科学 遺伝 Vol.71 (05)「iPS細胞の遺伝子変異をゲノム編集で修復する ー疾患研究と遺伝子治療の最先端」2017

Author(s)

Publisher

Data Source

[Book] 実験医学増刊号 "All About ゲノム編集"2016

Author(s)

Total Pages

Publisher

Data Source

[Book] "論文だけではわからない ゲノム編集成功の秘訣Q&A"「ヒト人工多能性幹細胞(iPS細胞)でのゲノム編集」2015

Author(s)

Publisher

Data Source

[Book] 医学のあゆみ, 患者由来iPS細胞を用いた神経疾患研究2015

Author(s)

Hotta Akitsu 堀田秋津

HOTTA Akitsu 堀田秋津

[Book] 生物の科学　遺伝　Vol.71 (05)「iPS細胞の遺伝子変異をゲノム編集で修復するー疾患研究と遺伝子治療の最先端」2017

[Book] 実験医学増刊号　"All About ゲノム編集"2016

[Book] "論文だけではわからないゲノム編集成功の秘訣Q&A"「ヒト人工多能性幹細胞(iPS細胞)でのゲノム編集」2015