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Shima Midori  嶋 緑倫

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… Alternative Names

Midori Shima  嶋 緑倫

Shima Modori  嶋 緑倫

SHIMA Midori  嶋 緑倫

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Researcher Number 30162663
Other IDs
External Links
Affiliation (Current) 2022: 奈良県立医科大学, 医学部, 副学長
Affiliation (based on the past Project Information) *help 2020 – 2021: 奈良県立医科大学, 医学部, 副学長
2017 – 2019: 奈良県立医科大学, 医学部, 教授
2013 – 2015: 奈良県立医科大学, 医学部, 教授
2008 – 2010: Nara Medical University, 医学部, 教授
2007: 兵庫県立大学, 医学部, 准教授 … More
2007: Nara Medical University, Faculty of Medicine, Associate Professor
2004 – 2006: 奈良県立医科大学, 医学部, 助教授
2004: Nara Medical University, Pediatrics, Associate Professor, 医学部・小児科, 助教授
2003: 奈良県立医科大学, 医学部小児科, 助教授
2002: 奈良県立医科大学, 医学部, 助教授
2000: Nara Medical University, Dept of Pediatrics, Associate Professor, 医学部・小児科, 助教授
1999 – 2000: 奈良県立医科大学, 医学部, 助教授
1998: 奈良県立医科大学, 医学部・小児科, 助教授
1993 – 1996: 奈良県立医科大学, 医学部, 助教授
1992: NARA MEDICAL UNIVERSITY, PEDIATRICS, ASSISTANT PROFESSOR, 医学部(小児科), 講師
1990 – 1991: 奈良県立医科大学, 医学部, 講師
1990: 奈良県立医科大学, 医学部・小児科, 講師
1990: Nara Medical University, Pediatrics, Assistant Professor, 医部部・小児科, 講師 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Pediatrics / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Pediatrics / Hematology / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
血友病A / 第VIII因子 / hemophilia A / 遺伝子治療 / factor VIII / トロンビン / 血友病 / 活性化 / 活性型第X因子 / 細胞治療 … More / インヒビター / 抗第VIII因子同種抗体 / inhibitor / 凝固波形 / トロンビン生成 / 第IX因子 / 小児血液学 / 第VIII因子活性 / モノクローナル抗体 / A2ドメイン / 抗体療法 / gene therapy / piggyBack / transposon / factor Ⅷ / 血友病A / 自己細胞 / 細胞移植 / 免疫応答 / 第VIIII因子遺伝子 / C2ドメイン / 同種抗体 / anti factor VIII alloantibody / factor VIII gene / Clot waveform / hemophilia / 不活性化 / 凝固機能 / プラスミン / 組織因子 / 止血モニタリング / 血液凝固 / 凝固速度 / 凝固加速度 / clot waveform analysis / thrombin generation / activation / inactivation / clotting function / plasmin / 第X因子 / 高機能型 / 活性型第IX因子 / リン脂質 / 内科 / 小児科 / 血液 / 血栓止血 / iPS細胞 / 細胞シート / 間葉系幹細胞 / 肝類洞内皮細胞 … More
Except Principal Investigator
第VIII因子 / 血友病 / 第IX因子 / 血友病A / VWF / 血栓症 / 肝臓 / 移植 / イヌ / ラット / ヒト杭体 / SPYMEG / インヒビター / イディオタイプ抗体 / 細胞融合 / 電気的細胞融 / 抗体産生細 / ヒト抗体 / インヒビタ / von Willebrand病(VWD) / von Willebrand因子(VWF) / VWF-Subunit / VWD TypeI / VWD TypeIIA / VWD TypeIIC / VWD TypeIID / VWD TypeIII / von Willebrand病(vWD) / von Willebrand因子(vWF) / vWF-Subunit / vWD Type I / vWD Type IIA / vWD Type IIC / vWD Type IID / vWD Type III / von Willebrand病 / vWD typeI / vWD typeIIA / vWD type / vWD Normandy rariant / vWF / 第VIII因子(F.VIII) / vWF遺伝子 / RFLPs / VNTR / 結合能 / von Willebrand disease / von Willebrand factor / vWD TypeI / vWD TypeIIA / vWD TypeIIB / vWD TypeIIC / vWF gene / vWF subunit / 生理的血流 / フローチャンバー / ADAMTS13 / フローチロンバー / factor VIII / physiologic blood flow / thrombosis / flow chamber / 保因者診断 / 出生前診断 / 胎児採血 / 遺伝子診断 / VS(chorionic villus sampling) / 血友病B / RFLP(restriction fragment length polymorphism) / 第IV因子 / CVS(chorionic villi sampling) / モノクローナル抗体 / RFLP(restriction fragment length polyworphism) / Hemophilia / Factor VIII / Factor IX / Carrier detection / Prenatal diagnosis / Fetal blood sampling / Chorionic villus sampling / Gene analysis / 小児がん / 播種性血管内凝固 / 凝固 / 線溶 / トロンビン・プラスミン生成試験 / 凝固線溶波形解析 / トロンビンプラスミン生成試験 / 肝類洞閉塞症候群 / 血栓性微小血管障害症 Less
  • Research Projects

    (14 results)
  • Research Products

    (181 results)
  • Co-Researchers

    (42 People)
  •  Development of Universal Cell Therapy for Hemophilia A Principal Investigator

    • Principal Investigator
      嶋 緑倫
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Nara Medical University
  •  Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis

    • Principal Investigator
      石原 卓
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Studies on molecular pathology of hemophilia A and gain-of-function of FVIIIPrincipal Investigator

    • Principal Investigator
      Midori Shima
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Establishment of the next generation treatment for hemophilia A by autologous cell implantationPrincipal Investigator

    • Principal Investigator
      Shima Modori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  血友病A患者からモノクローナルインヒビターと抗イディオタイプ抗体の作製と抗原解析

    • Principal Investigator
      山本 正雅
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Ohu University
  •  Basic study for establishment of novel antibody therapy for hemophilia A with an antibody enhancing factor VIII activityPrincipal Investigator

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Novel antithrombotic strategy based on the functional regulation of factor VIII/VWF complex

    • Principal Investigator
      YOSHIOKA Akira
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Study on the clotting function by clot waveform analysisPrincipal Investigator

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  In vitro study for clotting function aid activation mechanism in the gene therapy for haemophilia APrincipal Investigator

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Study about factor VIII expression and immunological influence in the gene therapy of hemophilia APrincipal Investigator

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  STUDIES FOR TREATMENT OF HEMOPHILIA A WITH INHBITOR USING CANINIE SYSTEMPrincipal Investigator

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      NARA MEDICAL UNIVERSITY
  •  肝細胞移植による血友病遺伝子治療に関する研究

    • Principal Investigator
      YOSHIOKA Akira (〓岡 章)
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Molecular genetic study on patients with various types of von Willebrand disease

    • Principal Investigator
      FUKUI Hiromu
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      NARA MEDICAL UNIVERSITY
  •  Immunological, Biological and Molecular Genetic Study on Prenatal Diagnosis of Hemophilia

    • Principal Investigator
      YOSHIOKA Akira
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University

All 2020 2019 2018 2017 2015 2014 2013 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 血液疾患 診断・治療指針2015

    • Author(s)
      嶋 緑倫
    • Total Pages
      576
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Book] 小児血液・腫瘍学2015

    • Author(s)
      嶋 緑倫
    • Total Pages
      608
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Book] 今口の診断指針 第6版2010

    • Author(s)
      嶋緑倫
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Book] 総合小児科診療のための小児科学レビュー2010 最新腫瘍文献と解説2010

    • Author(s)
      野上恵嗣、嶋緑倫
    • Publisher
      総合医学社
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Book] 血液凝固因子異常症,『内科学 特装版』2006

    • Author(s)
      嶋 緑倫, 吉岡 章
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-17390304
  • [Book] 血友病,『三輪血液病学 第3版』2006

    • Author(s)
      嶋 緑倫, 吉岡 章
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-17390304
  • [Book] 今日の小児診断指針2004

    • Author(s)
      嶋 緑倫
    • Total Pages
      3
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] An anti‐factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A2020

    • Author(s)
      Takeyama M, Nogami K, Matsumoto T, Noguchi-Sasaki M, Kitazawa T, Shima M.
    • Journal Title

      J Thromb Haemost

      Volume: 18 Pages: 825-833

    • DOI

      10.1111/jth.14746

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10125
  • [Journal Article] Assessment of self‐/parent‐reported quality of life in Japanese children with haemophilia using the Japanese version of KIDSCREEN‐522020

    • Author(s)
      Furuichi Yasuko、Nogami Keiji、Yada Koji、Nezu Satoko、Obayashi Kenji、Saeki Keigo、Kurumatani Norio、Nakajima Mitsuru、Kinoshita Seiji、Shima Midori
    • Journal Title

      Haemophilia

      Volume: 26 Pages: 243-250

    • DOI

      10.1111/hae.13945

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Emicizumab Improves Ex Vivo Clotting Function in Patients with Mild/Moderate Hemophilia A2020

    • Author(s)
      Nakajima Yuto、Nogami Keiji、Yada Koji、Furukawa Shoko、Noguchi-Sasaki Mariko、Hirata Michinori、Shima Midori
    • Journal Title

      Thrombosis and Haemostasis

      Volume: オンライン Pages: 968-976

    • DOI

      10.1055/s-0040-1710315

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-18K07798
  • [Journal Article] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function2020

    • Author(s)
      Onishi Tomoko、Nogami Keiji、Ishihara Takashi、Inoue Satoki、Kawaguchi Masahiko、Nishio Kenji、Fukushima Hidetada、Kobayashi Hiroshi、Amano Itsuto、Nishikubo Toshiya、Yamasaki Masaharu、Kasahara Masato、Shima Midori
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 120 Pages: 1257-1269

    • DOI

      10.1055/s-0040-1713890

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
  • [Journal Article] Emicizumab improves the stability and structure of fibrin clot derived from factor VIII‐deficient plasma, similar to the addition of factor VIII2020

    • Author(s)
      Shimonishi Naruto、Nogami Keiji、Ogiwara Kenichi、Matsumoto Tomoko、Nakazawa Fumie、Soeda Tetsuhiro、Hirata Michinori、Arai Nobuo、Shima Midori
    • Journal Title

      Haemophilia

      Volume: オンライン

    • DOI

      10.1111/hae.13961

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L‐asparaginase induction therapy in pediatric acute lymphoblastic leukemia2019

    • Author(s)
      Ishihara Takashi、Nogami Keiji、Ochi Satoshi、Ishida Toshiaki、Kosaka Yoshiyuki、Sawada Akihisa、Inoue Masami、Osone Shinya、Imamura Toshihiko、Hosoi Hajime、Shima Midori
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 67

    • DOI

      10.1002/pbc.28016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-19K08326
  • [Journal Article] Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation2019

    • Author(s)
      Ishihara Takashi、Nogami Keiji、Onishi Tomoko、Ogiwara Kenichi、Ochi Satoshi、Yamazaki Masaharu、Shima Midori
    • Journal Title

      Pediatrics International

      Volume: 61 Pages: 872-881

    • DOI

      10.1111/ped.13919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Journal Article] A novel simultaneous clot‐fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders2019

    • Author(s)
      Nogami K, Matsumoto T, Sasai K, Ogiwara K, Arai N, Shima M.
    • Journal Title

      Br.J. Haematol

      Volume: 187 Pages: 518-529

    • DOI

      10.1111/bjh.16111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127
  • [Journal Article] Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.2019

    • Author(s)
      Pipe SW, Shima M, Lehle M, Shapiro A, Chebon S, Fukutake K, Key NS, Portron A, Schmitt C, Podolak-Dawidziak M, Selak Bienz N, Hermans C, Campinha-Bacote A, Kiialainen A, Peerlinck K, Levy GG, Jiménez-Yuste V.
    • Journal Title

      Lancet Haematol

      Volume: 30054 Pages: 30057-30057

    • DOI

      10.1016/s2352-3026(19)30054-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation2019

    • Author(s)
      Furukawa S, Nogami K, Ogiwara K, Shima M.
    • Journal Title

      International Journal of Hematology

      Volume: 109 Pages: 390-401

    • DOI

      10.1007/s12185-019-02611-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231
  • [Journal Article] Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity2018

    • Author(s)
      Kitazawa Takehisa、Shima Midori
    • Journal Title

      International Journal of Hematology

      Volume: on line

    • DOI

      10.1007/s12185-018-2545-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] New therapies using nonfactor products for patients with hemophilia and inhibitors2018

    • Author(s)
      Nogami Keiji、Shima Midori
    • Journal Title

      Blood

      Volume: 133 Pages: 399-406

    • DOI

      10.1182/blood-2018-07-820712

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor.2018

    • Author(s)
      Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
    • Journal Title

      British Journal of Haematology

      Volume: ahead of printing Pages: 528-536

    • DOI

      10.1111/bjh.15209

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-18K07885
  • [Journal Article] Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V2018

    • Author(s)
      Yada Koji、Nogami Keiji、Shinozawa Keiko、Kitazawa Takehisa、Hattori Kunihiro、Amano Kagehiro、Fukutake Katsuyuki、Shima Midori
    • Journal Title

      British Journal of Haematology

      Volume: 183 Pages: 257-266

    • DOI

      10.1111/bjh.15525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody emicizumab2018

    • Author(s)
      Nogami K, Matsumoto T, Tabuchi Y, Soeda T, Arai N, Kitazawa T, Shima M
    • Journal Title

      J Thromb Haemost

      Volume: 未定 Pages: 1078-1088

    • DOI

      10.1111/jth.14022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07885
  • [Journal Article] A combined approach using global coagulation assays quickly differentiates coagulation disorders with prolonged aPTT and low levels of FVIII activity.2017

    • Author(s)
      Tomoko Matsumoto, Keiji Nogami, Midori Shima
    • Journal Title

      International Journal of Hematology

      Volume: 105(2) Pages: 174-183

    • DOI

      10.1007/s12185-016-2108-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-17H04231
  • [Journal Article] Long-term safety and efficacy of emicizumab in a phase 1/2 study in patients with hemophilia A with or without inhibitors.2017

    • Author(s)
      Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Kasai R, Yoneyama K, Yoshida H, Nogami K.
    • Journal Title

      Blood Advances

      Volume: 1(22) Pages: 1891-1899

    • DOI

      10.1182/bloodadvances.2017006684

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663
  • [Journal Article] Emicizumab Prophylaxis in Hemophilia A with Inhibitors.2017

    • Author(s)
      Wada H, Matsumoto T, Katayama N
    • Journal Title

      The NEW ENGLAND JOURNAL of MEDICINE

      Volume: 377 Pages: 2193-2194

    • DOI

      10.1056/nejmc1712683

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08645, KAKENHI-PROJECT-17H04231
  • [Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015

    • Author(s)
      Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
    • Journal Title

      Journal of Thrombosis Haemostasis

      Volume: 13 Pages: 1843-1853

    • DOI

      10.1111/jth.13118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
  • [Journal Article] Phenotypic heterogeneity of hemostasis in severe hemophilia.2015

    • Author(s)
      Nogami K, Shima M.
    • Journal Title

      Seminars in Thrombosis and Hemostasis

      Volume: 41(8) Pages: 826-831

    • DOI

      10.1055/s-0034-1395349

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] Delivery of full-length factor VIII using piggyBac vector to correct a mouse model of hemophilia A2014

    • Author(s)
      Hideto Matsui, Naoko Fujimoto, Noriko Sasakawa, Yasuhide Ohinata, Midori Shima, Shinya Yamanaka, Mitsuhiko Sugimotom Akitsu Hotta
    • Journal Title

      PLOS ONE

      Volume: 9(8)

    • DOI

      10.1371/journal.pone.0104957

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591559, KAKENHI-PROJECT-25293237, KAKENHI-PROJECT-25712030
  • [Journal Article] Towards standarization of clot waveform analysis and recommendations for its clinical applications.2013

    • Author(s)
      Shima M, Thachil J, Nair SC, Srivastava A.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 11(7) Pages: 1417-1420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] 血友病ワールド2013

    • Author(s)
      嶋 緑倫
    • Journal Title

      臨床血液

      Volume: 54(8) Pages: 736-743

    • NAID

      10031196290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] A novel cell-sheet technology that achives durable factor VIII delivery in a mouse model of hemophilia A2013

    • Author(s)
      Tatsumi K, Sugimoto M, Lillicrap D, Shima M, Ohashi K, Okano T, Matsui H.
    • Journal Title

      PLOS ONE

      Volume: 8(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis2013

    • Author(s)
      Matsumoto T, Nogami K, Shima M
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 110(4) Pages: 761-768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] 血友病2013

    • Author(s)
      嶋 緑倫
    • Journal Title

      臨床血液

      Volume: 54(2) Pages: 189-197

    • NAID

      10031157111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Journal Article] Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions.2011

    • Author(s)
      Hamada M, Sugimoto M, Matsui H, Mizuno T, Shida Y, Doi M, Fukushima H, Nishio K, Yoshioka A, Shima M.
    • Journal Title

      Thromb Haemost 1;105(2)

      Pages: 313-320

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Regulation of coagulation factors during liver regeneration in mice : Mechanism of factor VIII elevation in plasma.2011

    • Author(s)
      Tatsumi K, Ohashi K, Taminishi S, Sakurai Y, Ogiwara K, Yoshioka A, Okano T, Shima M.
    • Journal Title

      Thromb Res(Epub)

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Expression of coagulation factors from murine induced pluripotent stem cell-derived liver cells.2011

    • Author(s)
      Kasuda S, Tatsumi K, Sakurai Y, Kato J, Taminishi S, Takeda T, Ohashi K, Okano T, Hatake K, Shima M.
    • Journal Title

      Blood Coagul Fibrinolysis(Epub)

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Correlations between global clotting function tests, duration of operation, and postoperative chest tube drainage in pediatric cardiac surgery.2011

    • Author(s)
      Hayashi T, Sakurai Y, Fukuda K, Yada K, Ogiwara K, Matsumoto T, Yoshizawa H, Takahashi Y, Yoshikawa Y, Hayata Y, Taniguchi S, Shima M.
    • Journal Title

      Paediatr Anaesth(Epub)

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Functional life-long maintenance of engineered liver tissue in mice following transplantation under the kidney capsule.2010

    • Author(s)
      Ohashi K, Koyama F, Tatsumi K, Shima M, Park F, Nakajima Y, Okano T.
    • Journal Title

      J Tissue Eng Regen Med 4(2)

      Pages: 141-148

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010

    • Author(s)
      Nishiya K, Nogami K, Okada K, Matsuo O, Takeyama M, Ogiwara K, Shima M
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 104(1) Pages: 105-117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity.2010

    • Author(s)
      Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Hattori K, Shima M.
    • Journal Title

      Thromb Haemost 103(1)

      Pages: 94-102

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010

    • Author(s)
      Nishiya K, Nogami K, Okada K, Matsuo O, Takeyama M, Ogiwara K, Shima M.
    • Journal Title

      Thromb Haemost,Epub 5;104(1)

      Pages: 105-117

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010

    • Author(s)
      Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Hattori K, Shima M
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 103(1) Pages: 94-102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010

    • Author(s)
      Soeda T, Nogami K, Matsumoto T, Ogiwara K, Shima M
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 8(11) Pages: 2492-2503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Plasmin-induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010

    • Author(s)
      Ogiwara K, Nogami K, NishiyaK, Shima M
    • Journal Title

      Blood Coagulation & Fibrinolysis

      Volume: 21(6) Pages: 568-576

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Engineering liver tissues under the kidney capsule site provides therapeutic effects to hemophilia B mice.2010

    • Author(s)
      Ohashi K, Tatsumi K, Utoh R, Takagi S, Shima M, Okano T.
    • Journal Title

      Cell Transplant.Epub 19(6)

      Pages: 807-813

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Plasmin-induced procoagulant effects in the blood coagulation: a crucial role of coagulation factors V and VIII.2010

    • Author(s)
      Ogiwara K, Nogami K, Nishiya K, Shima M.
    • Journal Title

      Blood Coagul Fibrinolysis 21(6)

      Pages: 568-576

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII.2010

    • Author(s)
      Soeda T, Nogami K, Matsumoto T, Ogiwara K, Shima M.
    • Journal Title

      J Thromb Haemost 8(11)

      Pages: 2494-2503

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Characterization of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010

    • Author(s)
      Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Shima M.
    • Journal Title

      Thrombosis and Haemostasis 103

      Pages: 94-102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.2009

    • Author(s)
      Nogami K, Nishiya K, Saenko EL, Takeyama M, Ogiwara K, Yoshioka A, Shima M.
    • Journal Title

      J Biol Chem 13;284(11)

      Pages: 6934-6945

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Enhancement effect of ethanol on lipopolysaccharide-induced procoagulant status in human umbilical endothelial cells.2009

    • Author(s)
      Kasuda S, Nishiguchi M, Yoshida S, Ohtsu N, Adachi N, Sakurai Y, Shima M, Takahashi M, Hatake K, Kinoshita H.
    • Journal Title

      Soud Lek 54(4)

      Pages: 44-48

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] T hrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.2009

    • Author(s)
      Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y.
    • Journal Title

      Atherosclerosis 206(2)

      Pages: 418-426

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] von Willebrand factor protects the Ca2^<+->dependent structure of the factor VIII light chain.2009

    • Author(s)
      Takeyama M, Nogami K, Okuda M, Shima M.
    • Journal Title

      Br J Haematol 146(5)

      Pages: 531-537

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia.2009

    • Author(s)
      Tatsumi K, Ohashi K, Taminishi S, Takagi S, Utoh R, Yoshioka A, Shima M
    • Journal Title

      Okano T. World J Gastroenterol

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] The factor villa C2 domain (residues 2228-2240) interacts with the factor Ixa Gla domain in the factor xase complex.2009

    • Author(s)
      Soeda T, Nogami K, Nishiya K, Takeyama M, Ogiwara K, Sakata Y, Yoshioka A, Shima M.
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 3379-3388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Von Willebrand factor protects the Ca^<2+>-dependent structure of the factor VIII light chain2009

    • Author(s)
      Takeyama M, Nogami K, Okuda M, Shima M.
    • Journal Title

      British Journal of Haematology 146

      Pages: 531-537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Elevation of B cell-activating factor belonging to the tumour necrosis factor [corrected] family (BAFF) in haemophilia A patients with inhibitor.2009

    • Author(s)
      Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Yoshioka A, Shima M.
    • Journal Title

      Thromb Haemost 101(2)

      Pages: 408-410

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.2009

    • Author(s)
      Nogami K, Nishiya K, Saenko EL, Takeyama M, Ogiwara K, Shima M.
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 6934-6945

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A.2009

    • Author(s)
      Matsumoto T, Nogami K, Ogiwara K, Shima M.
    • Journal Title

      Int J Hematol 90(5)

      Pages: 576-582

    • NAID

      10026109911

    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Elevation of B cell-activating factor belonging to the tumour necrosis factor [corrected] family (BAFF) in haemophilia A patients with inhibitor.2009

    • Author(s)
      Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Shima M.
    • Journal Title

      Thrombosis and Haemostasis 101

      Pages: 408-410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice: Potential for cell-based therapy in haemophilia B2008

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Thrombosis and Haemostasis (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2008

    • Author(s)
      Nogami K, Yoshioka A, Shima M, et. al.
    • Journal Title

      Britishi Journal of Haematology 140

      Pages: 433-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B2008

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] New assays for monitoring haemophilia treatment2008

    • Author(s)
      Shima M, Matsumoto T, Ogiwara K
    • Journal Title

      Haemophilia (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII:A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] トロンビン生成試験の実際と応用2007

    • Author(s)
      嶋 緑倫、松本 智子
    • Journal Title

      日本血栓止血学会誌 18

      Pages: 217-225

    • NAID

      10026114695

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII : a crucial role for proteolytic cleavage at Arg^<336> responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      Journal of Biological Chemistry 282(8)

      Pages: 5287-5295

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 doma in2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama M, Tanaka I, Yoshioka A.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      International Journal of Hematology (in press)

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis.2007

    • Author(s)
      Takeyama M, Sakurai Y, Shima M, Yoshioka A, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Tekeyama M, Shima M, et al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18(1)

      Pages: 1-7

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko EL, Takeyama M, Giddings JC, Yoshioka A, Shima M.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma:An unusual and difficult diagnosis in a patient with mild Hemophilia A.2007

    • Author(s)
      Sakurai Y, Sugimoto H, Yoshida K, Shima M, et. al.
    • Journal Title

      International Journal of Hematology,

      Pages: 1-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007

    • Author(s)
      Takeyama M, Kasuda S, Sakurai Y, Shima M, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 397-402

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007

    • Author(s)
      Takeyama M, Shima M, et al.
    • Journal Title

      International Journal of Hematology (in press)

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Characterization of Factor VIII Inhibitors2007

    • Author(s)
      Shima, M
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor VIII-mediated global hemostasis in the absencen of von Willebrand factor.2007

    • Author(s)
      Takeyama M. Y.Shima M. Takeda T, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 397-402

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid,and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII : A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma : An unusual and difficult diagnosis in a patient with mild Hemophilia A2007

    • Author(s)
      Sakurai Y, Shima M, et al.
    • Journal Title

      International Journal of Hematology 85(1)

      Pages: 1-4

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko, EL, Takeyama M, Shima M, et. al.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Takeyama M, Sakurai Y, Shima M, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII: A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, Nishiya K, Tanaka I, Yoshioka A.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Characterization of Factor VIII Inhibitors2006

    • Author(s)
      Shima M
    • Journal Title

      International Journal of Hematology 83(2)

      Pages: 109-118

    • NAID

      10017278521

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006

    • Author(s)
      Sakurai Y, Shima M, Imai Y, et. al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Characterization of factor VIII inhibitors2006

    • Author(s)
      Midori Shima
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, Takeyama M, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 377-384

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site responsible for thrombin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, et al.
    • Journal Title

      Jounal of Thrombosis and Haemostasis 4(6)

      Pages: 1354-1360

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for throm bin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease.2006

    • Author(s)
      Sakurai Y, Shima M, Imai Y, et. al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] The measurement of low levels of factor VIII or factor IXin hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, et al.
    • Journal Title

      Jounal of Thrombosis and Haemostasis 4(2)

      Pages: 377-384

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Characterization of Factor VIII Inhibitors2006

    • Author(s)
      Shima M
    • Journal Title

      International Journal of Hematology 83

      Pages: 109-118

    • NAID

      10017278521

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006

    • Author(s)
      Sakurai Y, Shima M, et al.
    • Journal Title

      Blood Coagulation and Fibrinolysis 17(2)

      Pages: 151-154

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro2006

    • Author(s)
      Kasuda S, Shima M, et al.
    • Journal Title

      Alcoholism : Clinical and Experimental Research 30(9)

      Pages: 1608-1614

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, Takeyama M, et. al.
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      T Inoue T, M Shima, M Takeyama, T Matsumoto, K Nishiya, I Tanaka, Y Sakurai, JC Giddings, A Yoshioka
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for thrombin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and trombin generation assay2006

    • Author(s)
      Matsumoto T, Shima M, Takeyama M, Yoshida K, Tanaka I, Sakurai Y, Giles AR, Yoshioka A.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4・2

      Pages: 377-384

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Higher recovery of factor VIII(FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, Takeyama M, et. al.
    • Journal Title

      Haemophilia 12

      Pages: 110-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII.von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006

    • Author(s)
      Inoue T, Shima M, et al.
    • Journal Title

      Haemophilia 12(1)

      Pages: 110-113

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in patient with type 3 von Willebrand disease2005

    • Author(s)
      Y Sakurai, M Shima, Y Imai, A Omura, T Kirita, A Yoshioka
    • Journal Title

      Blood Coagulation and Fibrinolysis 17

      Pages: 151-154

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful steroid pulse treatment in childhood acquired haemophilia with nephritic syndrome2005

    • Author(s)
      M Sakai, M Shima, A Shiraharta
    • Journal Title

      Haemophilia 11

      Pages: 285-289

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Effectiveness of factor VIII infusions in haemophilia A patients with high responding inhibhitors.2004

    • Author(s)
      S Kasuda, I Tanaka, M Shima et al.
    • Journal Title

      Haemophilia 10

      Pages: 341-346

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Understanding the hemostatic effects of recombinant factor VIIa by clot wave form analysis.2004

    • Author(s)
      Midori Shima
    • Journal Title

      Seminars in Hematology 41

      Pages: 125-131

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Inversions of the factor VIII gene in Japanese patients with severe hemophilia A2004

    • Author(s)
      Kazuyoshi K, Hiroyuki Naka, Midori Shima et al.
    • Journal Title

      Int J Hematol 79

      Pages: 303-306

    • NAID

      10012924202

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Midori Shima. Understanding the hemostatic effects of recombinant factor VIIa by clot waveform analysis.2004

    • Author(s)
      Midori Shima
    • Journal Title

      Seminar in Hematology 41

      Pages: 125-131

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Inhibitors in hemophila A : mechanism of inhibition, management and perspectives2004

    • Author(s)
      Natalya M Ananyeva, Lacroix-Desmazes, Midori Shima et al.
    • Journal Title

      Coagulation and Fibrinolysis 15

      Pages: 109-124

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] A critical role for thrombin in platelet aggregation under high shear stress2004

    • Author(s)
      Yoshihiko Sakurai, Midori Shima, Masahiro Takeyama et al.
    • Journal Title

      Thrombosis Research 113

      Pages: 311-318

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Association of antiidiotypic antibodies with immune tolerance induction therapy for hemophilia A with inhibitors.2004

    • Author(s)
      Yoshihiko Sakurai, Midori Shima, Ichiro Tanaka et al.
    • Journal Title

      Hematologica 89

      Pages: 696-703

    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Understanding the hemostatic effects of recombinant factor VIIa by clot waveform analysis.2004

    • Author(s)
      Midori Shima
    • Journal Title

      Seminars in Hematology 41

      Pages: 125-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Replacement therapy with plasma-derived factor VIII concentrates induces skew in T-cell receptor usage and clonal expansion of CD8+ T-cell in HIV-seronegative hemophilia patients.2003

    • Author(s)
      Takaji Matsutani, Yoshihiko Sakurai, Takeshi Yoshioka, Yuji Tsuruta, Ryuji Suzuki, Midori Shima, Akira Yoshioka
    • Journal Title

      Thrombosis and Haemostasis 90

      Pages: 279-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Replacement therapy with plasma-derived factor VIII concentrates induces skew in T-cell receptor usage and clonal expansion of CD8^+ Tcell2003

    • Author(s)
      Takaji Matsutani, Yoshihiko Sakurai, Midori Shima et al.
    • Journal Title

      Thrombosis and Haemostasis 90

      Pages: 279-292

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Anticoagulant effects of a synthetic peptide containing residues Thr2253-Gln2270 within factor VIII C2 domain that selectively inhibits factor Xa-catalyzed factor VIII activation.2002

    • Author(s)
      KEIJI NOGAMI, MIDORI SHIMA, KATSUMI NISHIYA, KAZUYA HOSOKAWA, EVGUENI L SAENKO, JOHN C GIDDINGS, ICHIRO TANAKA, AKIRA YOSHIOKA
    • Journal Title

      British Journal of Haematology 116

      Pages: 868-874

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Anticoagulant effects of a synthetic peptide containing residues Thr-2253-Gln-2270 within factor VIII C2 domain2002

    • Author(s)
      Keiji Nogami, Midori Shima et al.
    • Journal Title

      British Journal of Haematology 116

      Pages: 868-874

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] The utility of activated partial thromboplastin time(aPTT) clot waveform analysis in the investigation of Haemophilia A patients with very low levels of Factor VIII activity (FVIII:C).2002

    • Author(s)
      Midori Shima, Tomoko Matsumoto, Kazuyoshi Fukuda, Youko Kubota, Ichiro Tanaka, Katumi Nishiya, ^*Alan R.Giles, Akira Yoshioka
    • Journal Title

      Thrombosis and Haemostasis 87

      Pages: 436-441

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation.2002

    • Author(s)
      Keiji Nogami, Midori Shima, Katsumi Nishiya, Kazuya Hosokawa, Evgueni L Saenko, Yoshihiko Sakurai, Masaru Shibata, Hiroshi Suzuki, Ichiro Tanaka, Akira Yoshioka
    • Journal Title

      Blood 99

      Pages: 3993-3998

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation2002

    • Author(s)
      Keiji Nogami, Midori Shima et al.
    • Journal Title

      Blood 99

      Pages: 3993-3998

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Human factor VIII inhibitor alloantibodies with a C2 epitope inhibit factor X-catalyzed factor VIII activation2002

    • Author(s)
      Keiji Nogami, Midori Shima et al.
    • Journal Title

      Thrombosis and Haemostasis 87

      Pages: 459-465

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Human factor VIII.inhibitor alloantibodies with a C2 epitope inhibit factor Xa-catalyzed factor VIII activation : a new anti-factor VIII inhibitory mechanism2002

    • Author(s)
      Keiji Nogami, Midori Shima, Katsumi Nishiya, Hiroshi Suzuki, Yoshihiko Sakurai, Ichiro Tanaka, John C Giddings, Evgueni L Saenko, Akira Yoshioka
    • Journal Title

      Thrombosis and Haemostasis 87

      Pages: 459-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] The utility of activated partial thromboplastin time clot waveform analysis in the investigation of hemophilia A2002

    • Author(s)
      Midori Shima, Tomoko Matsumoto et al.
    • Journal Title

      Thrombosis and Haemostasis 87

      Pages: 436-441

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570761
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B

    • Author(s)
      Tasumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice : Potential for cell-based therapy in haemophilia B.

    • Author(s)
      Tatsumi K, Ohashi K, Shima M, et. al.
    • Journal Title

      Thrombosis and Haemostasis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] New assays for monitoring haemophilia treatment

    • Author(s)
      Shima M, Matsumoto T, Ogiwara, K
    • Journal Title

      Haemophilia (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Patent] Blood Coagulation Factor VIII Activation-Enhancing Antibodies2009

    • Inventor(s)
      武山雅博, 野上恵嗣, 嶋緑倫, 鈴木司
    • Industrial Property Rights Holder
      奈良県立医科大学、中外製薬
    • Filing Date
      2009-08-06
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Patent] 血液凝固第VIII因子の活性を促進する抗体2006

    • Inventor(s)
      武山 雅博、野上 恵嗣、嶋 緑倫、鈴木 司
    • Industrial Property Rights Holder
      中外製薬
    • Industrial Property Number
      2006-235776
    • Filing Date
      2006-08-31
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Novel measurement of factor VIII by template matching method using weighed center on APTT clot waveform2019

    • Author(s)
      Shimonishi N, Ogiwara K, Nogami K, Oda Y, Kawabe T, Okazaki S, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Quantitative evaluation of fibrin clot strcture formed in the presence of emicizumab using scanning electron microscope2019

    • Author(s)
      Shimonishi N, Nogami K, Ogiwara K, Matsumoto T, Nakazawa F, Noguchi-Sasaki M, Hirata M, Arai N, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] トロンビン・プラスミン生成の低下がみられた肝類洞閉塞症候群(SOS)の1例2019

    • Author(s)
      石原 卓、野上 恵嗣、越智 聡史、水町 邦義、大西 智子、嶋 緑倫
    • Organizer
      第41回日本造血細胞移植学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] Additive effect on the global clotting function in moderate/mild hemophilia A by addition of emicizumab, evaluated by clot waveform analysis2019

    • Author(s)
      Nakajima Y, Nogami K, Yada K, Furukawa S, Noguchi M, Hirata M, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Residues 1680-1684 in the A3 domain of factor VIII contain a novel thrombin-interactive site responsible for proteolysitc clevage at Arg16892019

    • Author(s)
      Nakajima Y, Nogami K, Minami H, Sasai K, Shima M
    • Organizer
      61th American Society of Hematology Annual meeting & Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Bispecific antibodies and advances in non-genme therapy options in hemophilia2019

    • Author(s)
      Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019

    • Author(s)
      大西 智子、野上 恵嗣、伊藤 陽子、大前 隆志、石原 卓、嶋 緑倫
    • Organizer
      第122回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018

    • Author(s)
      Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
    • Organizer
      60thAmerican Society of Hematology Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第VIII因子の解明とFVIIIa代替バイスペシフィック抗体製剤の開発への道2018

    • Author(s)
      嶋 緑倫
    • Organizer
      第80回日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Mode of action and interaction of the bispecific antibody emicizumab2018

    • Author(s)
      Midori Shima
    • Organizer
      Annual meeting of the German Society of Thrombosis and Hmeaostais Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] R2159C 変異FVIII(FVIII-Ise)はC2 ドメインの構造機能変化をきたしている2018

    • Author(s)
      越智 聡史,武山 雅博,野上 恵嗣,嶋  緑倫
    • Organizer
      第40回日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第VIII因子A3ドメイン上の新規第IXa因子結合部位の同定2018

    • Author(s)
      武山 雅博, 野上 恵嗣, 笹井 香那, 嶋  緑倫
    • Organizer
      第80回日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Clot waveform analysis , laboratory monitoring of2018

    • Author(s)
      Midori Shima
    • Organizer
      Annual Meeting of Laboratory Medicine Congress and Exhibition
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site2018

    • Author(s)
      Masahiro Takeyama, Keiji Nogami, Kana Sasai, Midori Shima
    • Organizer
      60thAmerican Society of Hematology Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Monoclonal antibody-based therapies2018

    • Author(s)
      Midori Shima
    • Organizer
      European Society of hematology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Utility of converted factor VIII activity by thrombin generation assay for evaluation of clotting function among hemophilia A carriers2018

    • Author(s)
      Nogami K, Kawamura T, Shima M, Yada K
    • Organizer
      World Federation of Hemophilia 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第VIII 因子A3 残基1663-1666 にArg1689開裂を制御するトロンビン結合領域が存在する2018

    • Author(s)
      南  博明,野上 恵嗣,笹井 香那,古川 晶子,武山 雅博,嶋  緑倫
    • Organizer
      第40回日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Mode of Enhancement in the Global Hemostatic Potentials with Concomitant Use of Bypassing Agents and Emicizumab in Hemophilia A Patients with Inhibitor Evaluated by ROTEM2017

    • Author(s)
      Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017

    • Author(s)
      矢田 弘史, 野上 恵嗣, 竹中亜利沙, 河村 武志, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第VIII因子とインヒビター:どこまで解明されたか?2017

    • Author(s)
      嶋 緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Clinical and immunological profiles of Mild/Moderate hemophilia A patients with inhibitor2017

    • Author(s)
      Furukawa S, Nogami K, Shima M
    • Organizer
      7th East Asia Hemophilia Forum 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017

    • Author(s)
      松本 智子, 野上 恵嗣, 田渕 有香, 添田 哲弘, 新井 信夫, 北沢 剛久, 高岡 秀成, 服部 有宏, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Factor VIIIa mimetic bispecific antibody(Emicizumab) improves thrombus formation of von Willebrand disease under high shear flow conditions2017

    • Author(s)
      Shida Y, Nogami K, Yaoi H, Kitazawa T, Shima M
    • Organizer
      7th East Asia Hemophilia Forum 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017

    • Author(s)
      南  博明, 野上 恵嗣, 笹井 香那, 古川 晶子, 武山 雅博, 嶋  緑倫
    • Organizer
      第79回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017

    • Author(s)
      松本 智子, 野上 恵嗣, 笹井 香那, 荻原 建一, 竹中亜利沙, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Factor VIII A1 Residues 346-349 is a Novel Thrombin-binding Site Responsible for cleavage at Arg372 in the Heavy Chain2017

    • Author(s)
      Minami H, Nogami K, Sasai K, Furukawa S, Takeyama M, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第IX因子微量存在化におけるemicizumabの凝固能改善効果2017

    • Author(s)
      荻原 建一, 南  博明, 野上 恵嗣, 松本 智子, 北沢 剛久, 服部 有宏, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017

    • Author(s)
      古川 晶子, 野上 恵嗣, 荻原 建一, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Anti FIXa/FX Bispecific Antibody (Emicizumab) Enhances Plasma Procoagulant Activity In Hemophilia B in the Presence of Very Low Level of Factor IX2017

    • Author(s)
      Ogiwara K, Minami H, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Long-term phenotypic correction of hemophilia A mice by non-viral piggyBac transposon vector.2015

    • Author(s)
      Matsui H, Noda M, Shima M, Hotta A, Sugimoto M.
    • Organizer
      International Society on Thrombosis and Haemostasis (ISTH) 2015 Congress
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Double-layered cell sheet transplantation that achieves durable factor VIII delivery in the mouse model of hemophilia A2015

    • Author(s)
      Matsui H, Noda M, Utoh R, Shima M, Okano T, Sugimoto M.
    • Organizer
      The American Society of Gene and Cell Therapy 18th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2015-05-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Novel gene therapy strategy for hemophilia A by hydrodynamic gene delivery combined with non-viral piggyBac transposon vector in canine model2015

    • Author(s)
      Noda M, Matsui H, Matsunari Y, Ochi S, Shima M, Fukuoka Y, Sato T, Anai H, Kichikawa K, Nakayama M, Hotta A, Sugimoto M.
    • Organizer
      2015 Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Long-term phenotypic correction of hemophilia A by non-viral piggyBac trsposon vector2013

    • Author(s)
      Matsui H, Sugimoto M, Shima M, Fujimoto, Hotta A
    • Organizer
      The ASGCT 16th Annual Meeting
    • Place of Presentation
      Salt Lake City, U.S.A
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Establishment of novel cell-based therapy for hemophilia A2013

    • Author(s)
      Matsui H, Sugimoto M, Tatsumi K, Ohashi K, Shima M, Okano T
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Successful long-term phenotypic correction of hemophilia A mice by engineering functional factor VIII delivery system in vivo using endothelial cell sheets2013

    • Author(s)
      Matsui H, Tatsumi K, Ohashi k, Shima M, Sugimoto M, Okano T
    • Organizer
      ASH 55th Annual Meeting
    • Place of Presentation
      New Orleans, U.S.A
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Acquired Hemophilia2010

    • Author(s)
      Midori Shima
    • Organizer
      6th Congress of the Asia Pacific Society on Thrombosis and Haemostasis (APSTH Bali 2010)
    • Place of Presentation
      Nusa Dua Bali
    • Year and Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Presentation] Anti-A2 monoclonal antibody enhancing thrombin(and factor Xa)-catalyzed factor VIII activity2009

    • Author(s)
      Takeyama M, Nogami K, Soeda T, Ogiwara K, Nishiya K, Shima M.
    • Organizer
      22th Congress, The International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Boston, 米国
    • Year and Date
      2009-07-15
    • Data Source
      KAKENHI-PROJECT-20591259
  • [Presentation] 血友病患者の凝固因子捕充療法の標準化2007

    • Author(s)
      松下 正、 天野 景裕、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 血友病治療の最近の進歩2007

    • Author(s)
      嶋 緑倫
    • Organizer
      第49回日本臨床血液学会、第69回日本血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] インヒビター保有先天性血友病患者に対する止血治療ガイドライン案2007

    • Author(s)
      田中 一郎、 天野 景裕、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007

    • Author(s)
      武山 雅博、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして.2007

    • Author(s)
      西屋 克己、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 後天性血友病type2患者のトロンビン生成能低下の作用機序2007

    • Author(s)
      松本 智子、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] ヒト第VIII因子発現マウスES細胞を用いた血友病A細胞療法2007

    • Author(s)
      粕田 承吾、 櫻井 嘉彦、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 第VIII因子軽鎖C2は活性型第IX因子Glaドメインに結合する2007

    • Author(s)
      添田 哲弘、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Global assay using clot waveform and thrombin generation assays2007

    • Author(s)
      Midori Shima
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, Shima M, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 凝固波形およびトロンビン生成試験を用いた蕁麻疹患者における凝固能の検討2007

    • Author(s)
      櫻井 嘉彦、 竹田 知広、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Localization of fastor VIII interastive site within plasmin/plasminogen which is responseible for plasmin-catalyzed activation/inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-11-09
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 血友病Bに対する肝細胞移植治療の有効性〜マウスモデルにおける検討〜2007

    • Author(s)
      辰巳 公平、 大橋 一夫、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Role of direct interaction between factor C2 and factor IXa Gla domain in factor Xase complex.2007

    • Author(s)
      Soeda T, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Monitoring therapy to manage outcomes in hemophilia

    • Author(s)
      Shima M
    • Organizer
      5th East Asia Hemophilia Foundation
    • Place of Presentation
      Seoul, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] Successful long-term phenotypic correction of hemophilia A mice by multi-layerd endothelial cell sheet transplantation

    • Author(s)
      Hideto Matsui, Masashi Noda, Rie Utoh, Kohei Tatsumi, Kazuo Ohashi, Midori Shima, Mitsuhiko Sugimoto, Teruo Okano
    • Organizer
      The ASGCT 17th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-05-21 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-25293237
  • [Presentation] 血友病Aイヌモデルを用いた自己細胞移植による新規血友病A細胞治療法の開発検討

    • Author(s)
      野田正志、松井英人、松成泰典、越智すなお、嶋 緑倫、中山正成、杉本充彦
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2014-09-09 – 2014-09-12
    • Data Source
      KAKENHI-PROJECT-25293237
  • 1.  TANAKA Ichiro (00201616)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 2.  YOSHIOKA Akira (40106498)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KEIJI Nogami (50326328)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 61 results
  • 4.  SUGIMOTO Mitsuhiko (80192128)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  NISHIMURA Takuya (00192253)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NISHINO Masato (60164571)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SAKURAI Yoshihiko (80347559)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 8.  中島 充 (30183510)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SHIBATA Masaru (50405388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MATSUI Hideto (00571027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 11.  HOTTA Akitsu (50578002)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  FUKUI Hiromu (20075104)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAHSHI Yukihiro (60142379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  FUJIMURA Yoshihiro (80118033)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  MATSUMOTO Masanori (60316081)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KORESAWA Mitsuhiko (60107703)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  中島 祥介 (00142381)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  今中 康丈 (70231165)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  山本 正雅 (50150884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  志村 紀子 (60287480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  西久保 敏也 (20208169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  宮田 茂樹 (20239411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  阪井 利幸 (10175359)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  澤本 好克 (10264863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  中 宏之 (40281761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  武山 雅博 (30572010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 27.  矢田 弘史 (30635785)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 28.  松本 智子 (80642678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 29.  石原 卓 (00533712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 30.  大西 智子 (60645589)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 31.  堀江 恭二 (30333446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  辰巳 公平 (70555432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  荻原 建一 (50623500)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  小田 朗永 (80547703)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  坂田 飛鳥 (90528457)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  IMAMURA Toshihiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  〓岡 章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 38.  松下 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  細井 創
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  大日向 康秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  志田 泰明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  和田 英夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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