Shima Modori 嶋緑倫

… Alternative Names

Researcher Number	30162663
Other IDs
External Links
Affiliation (Current)	2018 : 奈良県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2018 : 奈良県立医科大学, 医学部, 教授 2013 – 2015 : 奈良県立医科大学, 医学部, 教授 2008 – 2010 : Nara Medical University, 医学部, 教授 2007 : 兵庫県立大学, 医学部, 准教授 2007 : Nara Medical University, Faculty of Medicine, Associate Professor … More
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics / Hematology / Pediatrics
Keywords	Principal Investigator 血友病A / 第VIII因子 / factor VIII / hemophilia A / 遺伝子治療 / 抗第VIII因子同種抗体 / 活性化 / 凝固波形 / トロンビン / トロンビン生成 … More Except Principal Investigator 第VIII因子 / 第IX因子 / 血友病 / 血友病A / VWF / 抗体産生細 / vWD TypeIIB / 結合能 / vWD TypeIIA / vWF gene / VWD TypeI / RFLP(restriction fragment length polyworphism) / Fetal blood sampling / Chorionic villus sampling / ヒト抗体 / VWF-Subunit / ヒト杭体 / von Willebrand disease / Prenatal diagnosis / von Willebrand因子(VWF) / thrombosis / vWF / VS(chorionic villus sampling) / vWD TypeIIC / イヌ / VNTR / 血友病B / vWD TypeI / factor VIII / von Willebrand病(VWD) / von Willebrand因子(vWF) / イディオタイプ抗体 / vWD typeI / vWD Type I / RFLPs / フローチロンバー / physiologic blood flow / 移植 / インヒビタ / CVS(chorionic villi sampling) / von Willebrand病 / 肝臓 / von Willebrand factor / 出生前診断 / 第IV因子 / SPYMEG / RFLP(restriction fragment length polymorphism) / Factor VIII / vWD type / 遺伝子診断 / フローチャンバー / vWD Type III / 生理的血流 / vWD Type IID / vWD Type IIC / vWD Type IIA / Hemophilia / von Willebrand病(vWD) / VWD TypeIID / ラット / Carrier detection / VWD TypeIIC / 保因者診断 / VWD TypeIIA / vWF subunit / vWD typeIIA / vWD Normandy rariant / ADAMTS13 / モノクローナル抗体 / VWD TypeIII / Factor IX / vWF-Subunit / flow chamber / 電気的細胞融 / インヒビター / 胎児採血 / 第VIII因子(F.VIII) / 細胞融合 / Gene analysis / vWF遺伝子 / 血栓症 Less

Studies on molecular pathology of hemophilia A and gain-of-function of FVIIIPrincipal InvestigatorOngoing
- Principal Investigator
  
  嶋緑倫
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Establishment of the next generation treatment for hemophilia A by autologous cell implantationPrincipal Investigator
- Principal Investigator
  
  Shima Modori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
血友病A患者からモノクローナルインヒビターと抗イディオタイプ抗体の作製と抗原解析
- Principal Investigator
  
  山本正雅
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Ohu University
Basic study for establishment of novel antibody therapy for hemophilia A with an antibody enhancing factor VIII activityPrincipal Investigator
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Novel antithrombotic strategy based on the functional regulation of factor VIII/VWF complex
- Principal Investigator
  
  YOSHIOKA Akira
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Study on the clotting function by clot waveform analysisPrincipal Investigator
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
In vitro study for clotting function aid activation mechanism in the gene therapy for haemophilia APrincipal Investigator
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Study about factor VIII expression and immunological influence in the gene therapy of hemophilia APrincipal Investigator
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
STUDIES FOR TREATMENT OF HEMOPHILIA A WITH INHBITOR USING CANINIE SYSTEMPrincipal Investigator
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  NARA MEDICAL UNIVERSITY
肝細胞移植による血友病遺伝子治療に関する研究
- Principal Investigator
  
  YOSHIOKA Akira
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Molecular genetic study on patients with various types of von Willebrand disease
- Principal Investigator
  
  FUKUI Hiromu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  NARA MEDICAL UNIVERSITY
Immunological, Biological and Molecular Genetic Study on Prenatal Diagnosis of Hemophilia
- Principal Investigator
  
  YOSHIOKA Akira
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University

[Book] 血液疾患　診断・治療指針2015
- Author(s)
  嶋　緑倫
- Total Pages
  576
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25293237
[Book] 小児血液・腫瘍学2015
- Author(s)
  嶋　緑倫
- Total Pages
  608
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25293237
[Book] 今口の診断指針第6版2010
- Author(s)
  嶋緑倫
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-20591259
[Book] 総合小児科診療のための小児科学レビュー2010 最新腫瘍文献と解説2010
- Author(s)
  野上恵嗣、嶋緑倫
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-20591259
[Book] 血液凝固因子異常症,『内科学特装版』2006
- Author(s)
  嶋緑倫, 吉岡章
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17390304
[Book] 血友病,『三輪血液病学第3版』2006
- Author(s)
  嶋緑倫, 吉岡章
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-17390304
[Book] 今日の小児診断指針2004
- Author(s)
  嶋緑倫
- Total Pages
  3
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor.2018
- Author(s)
  Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
- Journal Title
  
  British Journal of Hematology
  
  Volume : ahead of printing Pages : 528-536
- DOI
  10.1111/bjh.15209
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664
[Journal Article] Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody, emicizumab2018
- Author(s)
  Nogami K, Matsumoto T, Tabuchi Y, Soeda T, Arai N, Kitazawa T, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume : 未定
- DOI
  10.1111/jth.14022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] A combined approach using global coagulation assays quickly differentiates coagulation disorders with prolonged aPTT and low levels of FVIII activity.2017
- Author(s)
  Tomoko Matsumoto, Keiji Nogami, Midori Shima
- Journal Title
  
  International Journal of Hematology
  
  Volume : 105(2) Pages : 174-183
- DOI
  10.1007/s12185-016-2108-x
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-17H04231
[Journal Article] Long-term safety and efficacy of emicizumab in a phase 1/2 study in patients with hemophilia A with or without inhibitors.2017
- Author(s)
  Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Kasai R, Yoneyama K, Yoshida H, Nogami K.
- Journal Title
  
  Blood Advances
  
  Volume : 1(22) Pages : 1891-1899
- DOI
  10.1182/bloodadvances.2017006684
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663
[Journal Article] Emicizumab Prophylaxis in Hemophilia A with Inhibitors.2017
- Author(s)
  Wada H, Matsumoto T, Katayama N
- Journal Title
  
  The NEW ENGLAND JOURNAL of MEDICINE
  
  Volume : 377 Pages : 2193-2194
- DOI
  10.1056/nejmc1712683
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08645, KAKENHI-PROJECT-17H04231
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
- Journal Title
  
  J Thromb Haemost.
  
  Volume : 13 Pages : 1843-1853
- DOI
  10.1111/jth.13118
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
[Journal Article] Phenotypic heterogeneity of hemostasis in severe hemophilia.2015
- Author(s)
  Nogami K, Shima M.
- Journal Title
  
  Seminars in Thrombosis and Hemostasis
  
  Volume : 41(8) Pages : 826-831
- DOI
  10.1055/s-0034-1395349
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] Delivery of full-length factor VIII using piggyBac vector to correct a mouse model of hemophilia A2014
- Author(s)
  Hideto Matsui, Naoko Fujimoto, Noriko Sasakawa, Yasuhide Ohinata, Midori Shima, Shinya Yamanaka, Mitsuhiko Sugimotom Akitsu Hotta
- Journal Title
  
  PLOS ONE
  
  Volume : 9(8)
- DOI
  10.1371/journal.pone.0104957
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591559, KAKENHI-PROJECT-25293237, KAKENHI-PROJECT-25712030
[Journal Article] Towards standarization of clot waveform analysis and recommendations for its clinical applications.2013
- Author(s)
  Shima M, Thachil J, Nair SC, Srivastava A.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume : 11(7) Pages : 1417-1420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] 血友病ワールド2013
- Author(s)
  嶋　緑倫
- Journal Title
  
  臨床血液
  
  Volume : 54(8) Pages : 736-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] A novel cell-sheet technology that achives durable factor VIII delivery in a mouse model of hemophilia A2013
- Author(s)
  Tatsumi K, Sugimoto M, Lillicrap D, Shima M, Ohashi K, Okano T, Matsui H.
- Journal Title
  
  PLOS ONE
  
  Volume : 8(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis2013
- Author(s)
  Matsumoto T, Nogami K, Shima M
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume : 110(4) Pages : 761-768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] 血友病2013
- Author(s)
  嶋　緑倫
- Journal Title
  
  臨床血液
  
  Volume : 54(2) Pages : 189-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293237
[Journal Article] Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions.2011
- Author(s)
  Hamada M, Sugimoto M, Matsui H, Mizuno T, Shida Y, Doi M, Fukushima H, Nishio K, Yoshioka A, Shima M.
- Journal Title
  
  Thromb Haemost 1;105(2)
  
  Pages : 313-320
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Regulation of coagulation factors during liver regeneration in mice : Mechanism of factor VIII elevation in plasma.2011
- Author(s)
  Tatsumi K, Ohashi K, Taminishi S, Sakurai Y, Ogiwara K, Yoshioka A, Okano T, Shima M.
- Journal Title
  
  Thromb Res(Epub)
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Expression of coagulation factors from murine induced pluripotent stem cell-derived liver cells.2011
- Author(s)
  Kasuda S, Tatsumi K, Sakurai Y, Kato J, Taminishi S, Takeda T, Ohashi K, Okano T, Hatake K, Shima M.
- Journal Title
  
  Blood Coagul Fibrinolysis(Epub)
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Correlations between global clotting function tests, duration of operation, and postoperative chest tube drainage in pediatric cardiac surgery.2011
- Author(s)
  Hayashi T, Sakurai Y, Fukuda K, Yada K, Ogiwara K, Matsumoto T, Yoshizawa H, Takahashi Y, Yoshikawa Y, Hayata Y, Taniguchi S, Shima M.
- Journal Title
  
  Paediatr Anaesth(Epub)
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Functional life-long maintenance of engineered liver tissue in mice following transplantation under the kidney capsule.2010
- Author(s)
  Ohashi K, Koyama F, Tatsumi K, Shima M, Park F, Nakajima Y, Okano T.
- Journal Title
  
  J Tissue Eng Regen Med 4(2)
  
  Pages : 141-148
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010
- Author(s)
  Nishiya K, Nogami K, Okada K, Matsuo O, Takeyama M, Ogiwara K, Shima M
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume : 104(1) Pages : 105-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity.2010
- Author(s)
  Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Hattori K, Shima M.
- Journal Title
  
  Thromb Haemost 103(1)
  
  Pages : 94-102
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010
- Author(s)
  Nishiya K, Nogami K, Okada K, Matsuo O, Takeyama M, Ogiwara K, Shima M.
- Journal Title
  
  Thromb Haemost,Epub 5;104(1)
  
  Pages : 105-117
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010
- Author(s)
  Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Hattori K, Shima M
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume : 103(1) Pages : 94-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010
- Author(s)
  Soeda T, Nogami K, Matsumoto T, Ogiwara K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume : 8(11) Pages : 2492-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Plasmin-induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010
- Author(s)
  Ogiwara K, Nogami K, NishiyaK, Shima M
- Journal Title
  
  Blood Coagulation & Fibrinolysis
  
  Volume : 21(6) Pages : 568-576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Engineering liver tissues under the kidney capsule site provides therapeutic effects to hemophilia B mice.2010
- Author(s)
  Ohashi K, Tatsumi K, Utoh R, Takagi S, Shima M, Okano T.
- Journal Title
  
  Cell Transplant.Epub 19(6)
  
  Pages : 807-813
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Plasmin-induced procoagulant effects in the blood coagulation: a crucial role of coagulation factors V and VIII.2010
- Author(s)
  Ogiwara K, Nogami K, Nishiya K, Shima M.
- Journal Title
  
  Blood Coagul Fibrinolysis 21(6)
  
  Pages : 568-576
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII.2010
- Author(s)
  Soeda T, Nogami K, Matsumoto T, Ogiwara K, Shima M.
- Journal Title
  
  J Thromb Haemost 8(11)
  
  Pages : 2494-2503
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Characterization of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010
- Author(s)
  Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis 103
  
  Pages : 94-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.2009
- Author(s)
  Nogami K, Nishiya K, Saenko EL, Takeyama M, Ogiwara K, Yoshioka A, Shima M.
- Journal Title
  
  J Biol Chem 13;284(11)
  
  Pages : 6934-6945
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Enhancement effect of ethanol on lipopolysaccharide-induced procoagulant status in human umbilical endothelial cells.2009
- Author(s)
  Kasuda S, Nishiguchi M, Yoshida S, Ohtsu N, Adachi N, Sakurai Y, Shima M, Takahashi M, Hatake K, Kinoshita H.
- Journal Title
  
  Soud Lek 54(4)
  
  Pages : 44-48
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] T hrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.2009
- Author(s)
  Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y.
- Journal Title
  
  Atherosclerosis 206(2)
  
  Pages : 418-426
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] von Willebrand factor protects the Ca2^<+->dependent structure of the factor VIII light chain.2009
- Author(s)
  Takeyama M, Nogami K, Okuda M, Shima M.
- Journal Title
  
  Br J Haematol 146(5)
  
  Pages : 531-537
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia.2009
- Author(s)
  Tatsumi K, Ohashi K, Taminishi S, Takagi S, Utoh R, Yoshioka A, Shima M
- Journal Title
  
  Okano T. World J Gastroenterol
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] The factor villa C2 domain (residues 2228-2240) interacts with the factor Ixa Gla domain in the factor xase complex.2009
- Author(s)
  Soeda T, Nogami K, Nishiya K, Takeyama M, Ogiwara K, Sakata Y, Yoshioka A, Shima M.
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages : 3379-3388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Von Willebrand factor protects the Ca^<2+>-dependent structure of the factor VIII light chain2009
- Author(s)
  Takeyama M, Nogami K, Okuda M, Shima M.
- Journal Title
  
  British Journal of Haematology 146
  
  Pages : 531-537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Elevation of B cell-activating factor belonging to the tumour necrosis factor [corrected] family (BAFF) in haemophilia A patients with inhibitor.2009
- Author(s)
  Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Yoshioka A, Shima M.
- Journal Title
  
  Thromb Haemost 101(2)
  
  Pages : 408-410
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.2009
- Author(s)
  Nogami K, Nishiya K, Saenko EL, Takeyama M, Ogiwara K, Shima M.
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages : 6934-6945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A.2009
- Author(s)
  Matsumoto T, Nogami K, Ogiwara K, Shima M.
- Journal Title
  
  Int J Hematol 90(5)
  
  Pages : 576-582
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Elevation of B cell-activating factor belonging to the tumour necrosis factor [corrected] family (BAFF) in haemophilia A patients with inhibitor.2009
- Author(s)
  Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis 101
  
  Pages : 408-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591259
[Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice: Potential for cell-based therapy in haemophilia B2008
- Author(s)
  Tatsumi K, Ohashi K, Shima M, et. al.
- Journal Title
  
  Thrombosis and Haemostasis (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008
- Author(s)
  Nogami K, Nishiya K, Shima M, et. al.
- Journal Title
  
  Biochimica et Biophysica Acta (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2008
- Author(s)
  Nogami K, Yoshioka A, Shima M, et. al.
- Journal Title
  
  Britishi Journal of Haematology 140
  
  Pages : 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B2008
- Author(s)
  Tatsumi K, Ohashi K, Shima M, et. al.
- Journal Title
  
  Transplantation (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] New assays for monitoring haemophilia treatment2008
- Author(s)
  Shima M, Matsumoto T, Ogiwara K
- Journal Title
  
  Haemophilia (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII:A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007
- Author(s)
  Nogami K, Shima M, Matsumoto T, et. al.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages : 5287-5295
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] トロンビン生成試験の実際と応用2007
- Author(s)
  嶋緑倫、松本智子
- Journal Title
  
  日本血栓止血学会誌 18
  
  Pages : 217-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII : a crucial role for proteolytic cleavage at Arg^<336> responsible for plasmin-catalyzed factor VIII inactivation2007
- Author(s)
  Nogami K, Shima M, et al.
- Journal Title
  
  Journal of Biological Chemistry 282(8)
  
  Pages : 5287-5295
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 doma in2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama M, Tanaka I, Yoshioka A.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages : 317-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, et al.
- Journal Title
  
  International Journal of Hematology (in press)
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis.2007
- Author(s)
  Takeyama M, Sakurai Y, Shima M, Yoshioka A, et. al.
- Journal Title
  
  Blood Coagulation & Fibrinolysis 18
  
  Pages : 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007
- Author(s)
  Tekeyama M, Shima M, et al.
- Journal Title
  
  Blood Coagulation ＆ Fibrinolysis 18(1)
  
  Pages : 1-7
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007
- Author(s)
  Nogami K, Saenko EL, Takeyama M, Giddings JC, Yoshioka A, Shima M.
- Journal Title
  
  British Journal of Haematology 140
  
  Pages : 433-443
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma:An unusual and difficult diagnosis in a patient with mild Hemophilia A.2007
- Author(s)
  Sakurai Y, Sugimoto H, Yoshida K, Shima M, et. al.
- Journal Title
  
  International Journal of Hematology,
  
  Pages : 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007
- Author(s)
  Takeyama M, Kasuda S, Sakurai Y, Shima M, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages : 397-402
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor VIII-mediated global hemostasis in the absence of von Willebrand factor2007
- Author(s)
  Takeyama M, Shima M, et al.
- Journal Title
  
  International Journal of Hematology (in press)
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Characterization of Factor VIII Inhibitors2007
- Author(s)
  Shima, M
- Journal Title
  
  International Journal of Hematology 83
  
  Pages : 109-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor VIII-mediated global hemostasis in the absencen of von Willebrand factor.2007
- Author(s)
  Takeyama M. Y.Shima M. Takeda T, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages : 397-402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid,and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages : 317-322
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII : A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages : 5287-5295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Superficial fibromatosis mimicking subcutaneous hematoma : An unusual and difficult diagnosis in a patient with mild Hemophilia A2007
- Author(s)
  Sakurai Y, Shima M, et al.
- Journal Title
  
  International Journal of Hematology 85(1)
  
  Pages : 1-4
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007
- Author(s)
  Nogami K, Saenko, EL, Takeyama M, Shima M, et. al.
- Journal Title
  
  British Journal of Haematology 140
  
  Pages : 433-443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Heparin-induced inhibitory effects of a prothrombin complex concentrate on global tests of haemostasis2007
- Author(s)
  Takeyama M, Sakurai Y, Shima M, et. al.
- Journal Title
  
  Blood Coagulation & Fibrinolysis 18
  
  Pages : 1-7
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages : 317-322
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII: A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007
- Author(s)
  Nogami K, Shima M, Matsumoto T, Nishiya K, Tanaka I, Yoshioka A.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages : 5287-5295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Characterization of Factor VIII Inhibitors2006
- Author(s)
  Shima M
- Journal Title
  
  International Journal of Hematology 83(2)
  
  Pages : 109-118
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006
- Author(s)
  Sakurai Y, Shima M, Imai Y, et. al.
- Journal Title
  
  Blood Coagulation and Fibrinolysis 17
  
  Pages : 151-154
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Characterization of factor VIII inhibitors2006
- Author(s)
  Midori Shima
- Journal Title
  
  International Journal of Hematology 83
  
  Pages : 109-118
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006
- Author(s)
  Matsumoto T, Shima M, Takeyama M, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4
  
  Pages : 377-384
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor V C2 domain contains a major thrombin-binding site responsible for thrombin-catalyzed factor V activation2006
- Author(s)
  Suzuki H, Shima M, et al.
- Journal Title
  
  Jounal of Thrombosis and Haemostasis 4(6)
  
  Pages : 1354-1360
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for throm bin-catalyzed factor V activation2006
- Author(s)
  Suzuki H, Shima M, Nogami K, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4
  
  Pages : 1354-1360
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease.2006
- Author(s)
  Sakurai Y, Shima M, Imai Y, et. al.
- Journal Title
  
  Blood Coagulation and Fibrinolysis 17
  
  Pages : 151-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] The measurement of low levels of factor VIII or factor IXin hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay2006
- Author(s)
  Matsumoto T, Shima M, et al.
- Journal Title
  
  Jounal of Thrombosis and Haemostasis 4(2)
  
  Pages : 377-384
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Characterization of Factor VIII Inhibitors2006
- Author(s)
  Shima M
- Journal Title
  
  International Journal of Hematology 83
  
  Pages : 109-118
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in a patient with type 3 von Willebrand disease2006
- Author(s)
  Sakurai Y, Shima M, et al.
- Journal Title
  
  Blood Coagulation and Fibrinolysis 17(2)
  
  Pages : 151-154
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro2006
- Author(s)
  Kasuda S, Shima M, et al.
- Journal Title
  
  Alcoholism : Clinical and Experimental Research 30(9)
  
  Pages : 1608-1614
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006
- Author(s)
  Inoue T, Shima M, Takeyama M, et. al.
- Journal Title
  
  Haemophilia 12
  
  Pages : 110-113
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006
- Author(s)
  T Inoue T, M Shima, M Takeyama, T Matsumoto, K Nishiya, I Tanaka, Y Sakurai, JC Giddings, A Yoshioka
- Journal Title
  
  Haemophilia 12
  
  Pages : 110-113
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for thrombin-catalyzed factor V activation2006
- Author(s)
  Suzuki H, Shima M, Nogami K, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4
  
  Pages : 1354-1360
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and trombin generation assay2006
- Author(s)
  Matsumoto T, Shima M, Takeyama M, Yoshida K, Tanaka I, Sakurai Y, Giles AR, Yoshioka A.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4・2
  
  Pages : 377-384
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Higher recovery of factor VIII(FVIII) with intermediate FVIII/von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006
- Author(s)
  Inoue T, Shima M, Takeyama M, et. al.
- Journal Title
  
  Haemophilia 12
  
  Pages : 110-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Higher recovery of factor VIII (FVIII) with intermediate FVIII.von Willebrand factor concentrate than with recombinant FVIII in a haemophilia A patient with an inhibitor2006
- Author(s)
  Inoue T, Shima M, et al.
- Journal Title
  
  Haemophilia 12(1)
  
  Pages : 110-113
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful use of recombinant factor VIII devoid of von Willebrand factor during multiple teeth extractions in patient with type 3 von Willebrand disease2005
- Author(s)
  Y Sakurai, M Shima, Y Imai, A Omura, T Kirita, A Yoshioka
- Journal Title
  
  Blood Coagulation and Fibrinolysis 17
  
  Pages : 151-154
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful steroid pulse treatment in childhood acquired haemophilia with nephritic syndrome2005
- Author(s)
  M Sakai, M Shima, A Shiraharta
- Journal Title
  
  Haemophilia 11
  
  Pages : 285-289
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Effectiveness of factor VIII infusions in haemophilia A patients with high responding inhibhitors.2004
- Author(s)
  S Kasuda, I Tanaka, M Shima et al.
- Journal Title
  
  Haemophilia 10
  
  Pages : 341-346
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Understanding the hemostatic effects of recombinant factor VIIa by clot wave form analysis.2004
- Author(s)
  Midori Shima
- Journal Title
  
  Seminars in Hematology 41
  
  Pages : 125-131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Inversions of the factor VIII gene in Japanese patients with severe hemophilia A2004
- Author(s)
  Kazuyoshi K, Hiroyuki Naka, Midori Shima et al.
- Journal Title
  
  Int J Hematol 79
  
  Pages : 303-306
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Midori Shima. Understanding the hemostatic effects of recombinant factor VIIa by clot waveform analysis.2004
- Author(s)
  Midori Shima
- Journal Title
  
  Seminar in Hematology 41
  
  Pages : 125-131
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Inhibitors in hemophila A : mechanism of inhibition, management and perspectives2004
- Author(s)
  Natalya M Ananyeva, Lacroix-Desmazes, Midori Shima et al.
- Journal Title
  
  Coagulation and Fibrinolysis 15
  
  Pages : 109-124
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] A critical role for thrombin in platelet aggregation under high shear stress2004
- Author(s)
  Yoshihiko Sakurai, Midori Shima, Masahiro Takeyama et al.
- Journal Title
  
  Thrombosis Research 113
  
  Pages : 311-318
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Association of antiidiotypic antibodies with immune tolerance induction therapy for hemophilia A with inhibitors.2004
- Author(s)
  Yoshihiko Sakurai, Midori Shima, Ichiro Tanaka et al.
- Journal Title
  
  Hematologica 89
  
  Pages : 696-703
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Understanding the hemostatic effects of recombinant factor VIIa by clot waveform analysis.2004
- Author(s)
  Midori Shima
- Journal Title
  
  Seminars in Hematology 41
  
  Pages : 125-131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Replacement therapy with plasma-derived factor VIII concentrates induces skew in T-cell receptor usage and clonal expansion of CD8+ T-cell in HIV-seronegative hemophilia patients.2003
- Author(s)
  Takaji Matsutani, Yoshihiko Sakurai, Takeshi Yoshioka, Yuji Tsuruta, Ryuji Suzuki, Midori Shima, Akira Yoshioka
- Journal Title
  
  Thrombosis and Haemostasis 90
  
  Pages : 279-292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Replacement therapy with plasma-derived factor VIII concentrates induces skew in T-cell receptor usage and clonal expansion of CD8^+ Tcell2003
- Author(s)
  Takaji Matsutani, Yoshihiko Sakurai, Midori Shima et al.
- Journal Title
  
  Thrombosis and Haemostasis 90
  
  Pages : 279-292
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Anticoagulant effects of a synthetic peptide containing residues Thr2253-Gln2270 within factor VIII C2 domain that selectively inhibits factor Xa-catalyzed factor VIII activation.2002
- Author(s)
  KEIJI NOGAMI, MIDORI SHIMA, KATSUMI NISHIYA, KAZUYA HOSOKAWA, EVGUENI L SAENKO, JOHN C GIDDINGS, ICHIRO TANAKA, AKIRA YOSHIOKA
- Journal Title
  
  British Journal of Haematology 116
  
  Pages : 868-874
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Anticoagulant effects of a synthetic peptide containing residues Thr-2253-Gln-2270 within factor VIII C2 domain2002
- Author(s)
  Keiji Nogami, Midori Shima et al.
- Journal Title
  
  British Journal of Haematology 116
  
  Pages : 868-874
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] The utility of activated partial thromboplastin time(aPTT) clot waveform analysis in the investigation of Haemophilia A patients with very low levels of Factor VIII activity (FVIII:C).2002
- Author(s)
  Midori Shima, Tomoko Matsumoto, Kazuyoshi Fukuda, Youko Kubota, Ichiro Tanaka, Katumi Nishiya, ^*Alan R.Giles, Akira Yoshioka
- Journal Title
  
  Thrombosis and Haemostasis 87
  
  Pages : 436-441
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation.2002
- Author(s)
  Keiji Nogami, Midori Shima, Katsumi Nishiya, Kazuya Hosokawa, Evgueni L Saenko, Yoshihiko Sakurai, Masaru Shibata, Hiroshi Suzuki, Ichiro Tanaka, Akira Yoshioka
- Journal Title
  
  Blood 99
  
  Pages : 3993-3998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation2002
- Author(s)
  Keiji Nogami, Midori Shima et al.
- Journal Title
  
  Blood 99
  
  Pages : 3993-3998
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Human factor VIII inhibitor alloantibodies with a C2 epitope inhibit factor X-catalyzed factor VIII activation2002
- Author(s)
  Keiji Nogami, Midori Shima et al.
- Journal Title
  
  Thrombosis and Haemostasis 87
  
  Pages : 459-465
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Human factor VIII.inhibitor alloantibodies with a C2 epitope inhibit factor Xa-catalyzed factor VIII activation : a new anti-factor VIII inhibitory mechanism2002
- Author(s)
  Keiji Nogami, Midori Shima, Katsumi Nishiya, Hiroshi Suzuki, Yoshihiko Sakurai, Ichiro Tanaka, John C Giddings, Evgueni L Saenko, Akira Yoshioka
- Journal Title
  
  Thrombosis and Haemostasis 87
  
  Pages : 459-465
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] The utility of activated partial thromboplastin time clot waveform analysis in the investigation of hemophilia A2002
- Author(s)
  Midori Shima, Tomoko Matsumoto et al.
- Journal Title
  
  Thrombosis and Haemostasis 87
  
  Pages : 436-441
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570761
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain
- Author(s)
  Nogami K, Nishiya K, Shima M, et. al.
- Journal Title
  
  Biochimica et Biophysica Acta (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B
- Author(s)
  Tasumi K, Ohashi K, Shima M, et. al.
- Journal Title
  
  Transplantation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Successful in vivo propagation of factor IX-producing hepatocytes in mice : Potential for cell-based therapy in haemophilia B.
- Author(s)
  Tatsumi K, Ohashi K, Shima M, et. al.
- Journal Title
  
  Thrombosis and Haemostasis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] New assays for monitoring haemophilia treatment
- Author(s)
  Shima M, Matsumoto T, Ogiwara, K
- Journal Title
  
  Haemophilia (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Mode of Enhancement in the Global Hemostatic Potentials with Concomitant Use of Bypassing Agents and Emicizumab in Hemophilia A Patients with Inhibitor Evaluated by ROTEM2017
- Author(s)
  Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田　弘史, 野上　恵嗣, 竹中亜利沙, 河村　武志, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第VIII因子とインヒビター：どこまで解明されたか？2017
- Author(s)
  嶋　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Clinical and immunological profiles of Mild/Moderate hemophilia A patients with inhibitor2017
- Author(s)
  Furukawa S, Nogami K, Shima M
- Organizer
  7th East Asia Hemophilia Forum 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017
- Author(s)
  松本　智子, 野上　恵嗣, 田渕　有香, 添田　哲弘, 新井　信夫, 北沢　剛久, 高岡　秀成, 服部　有宏, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Factor VIIIa mimetic bispecific antibody(Emicizumab) improves thrombus formation of von Willebrand disease under high shear flow conditions2017
- Author(s)
  Shida Y, Nogami K, Yaoi H, Kitazawa T, Shima M
- Organizer
  7th East Asia Hemophilia Forum 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017
- Author(s)
  南　　博明, 野上　恵嗣, 笹井　香那, 古川　晶子, 武山　雅博, 嶋　　緑倫
- Organizer
  第79回　日本血液学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017
- Author(s)
  松本　智子, 野上　恵嗣, 笹井　香那, 荻原　建一, 竹中亜利沙, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Factor VIII A1 Residues 346-349 is a Novel Thrombin-binding Site Responsible for cleavage at Arg372 in the Heavy Chain2017
- Author(s)
  Minami H, Nogami K, Sasai K, Furukawa S, Takeyama M, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第IX因子微量存在化におけるemicizumabの凝固能改善効果2017
- Author(s)
  荻原　建一, 南　　博明, 野上　恵嗣, 松本　智子, 北沢　剛久, 服部　有宏, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017
- Author(s)
  古川　晶子, 野上　恵嗣, 荻原　建一, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Anti FIXa/FX Bispecific Antibody (Emicizumab) Enhances Plasma Procoagulant Activity In Hemophilia B in the Presence of Very Low Level of Factor IX2017
- Author(s)
  Ogiwara K, Minami H, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Long-term phenotypic correction of hemophilia A mice by non-viral piggyBac transposon vector.2015
- Author(s)
  Matsui H, Noda M, Shima M, Hotta A, Sugimoto M.
- Organizer
  International Society on Thrombosis and Haemostasis (ISTH) 2015 Congress
- Place of Presentation
  Toronto, Canada
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Double-layered cell sheet transplantation that achieves durable factor VIII delivery in the mouse model of hemophilia A2015
- Author(s)
  Matsui H, Noda M, Utoh R, Shima M, Okano T, Sugimoto M.
- Organizer
  The American Society of Gene and Cell Therapy 18th Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Novel gene therapy strategy for hemophilia A by hydrodynamic gene delivery combined with non-viral piggyBac transposon vector in canine model2015
- Author(s)
  Noda M, Matsui H, Matsunari Y, Ochi S, Shima M, Fukuoka Y, Sato T, Anai H, Kichikawa K, Nakayama M, Hotta A, Sugimoto M.
- Organizer
  2015 Annual Meeting of the American Society of Hematology
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Long-term phenotypic correction of hemophilia A by non-viral piggyBac trsposon vector2013
- Author(s)
  Matsui H, Sugimoto M, Shima M, Fujimoto, Hotta A
- Organizer
  The ASGCT 16th Annual Meeting
- Place of Presentation
  Salt Lake City, U.S.A
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Establishment of novel cell-based therapy for hemophilia A2013
- Author(s)
  Matsui H, Sugimoto M, Tatsumi K, Ohashi K, Shima M, Okano T
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Successful long-term phenotypic correction of hemophilia A mice by engineering functional factor VIII delivery system in vivo using endothelial cell sheets2013
- Author(s)
  Matsui H, Tatsumi K, Ohashi k, Shima M, Sugimoto M, Okano T
- Organizer
  ASH 55th Annual Meeting
- Place of Presentation
  New Orleans, U.S.A
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Acquired Hemophilia2010
- Author(s)
  Midori Shima
- Organizer
  6th Congress of the Asia Pacific Society on Thrombosis and Haemostasis (APSTH Bali 2010)
- Place of Presentation
  Nusa Dua Bali
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20591259
[Presentation] Anti-A2 monoclonal antibody enhancing thrombin(and factor Xa)-catalyzed factor VIII activity2009
- Author(s)
  Takeyama M, Nogami K, Soeda T, Ogiwara K, Nishiya K, Shima M.
- Organizer
  22th Congress, The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston, 米国
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-20591259
[Presentation] 血友病患者の凝固因子捕充療法の標準化2007
- Author(s)
  松下正、天野景裕、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] インヒビター保有先天性血友病患者に対する止血治療ガイドライン案2007
- Author(s)
  田中一郎、天野景裕、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 血友病治療の最近の進歩2007
- Author(s)
  嶋緑倫
- Organizer
  第49回日本臨床血液学会、第69回日本血液学会合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007
- Author(s)
  武山雅博、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして.2007
- Author(s)
  西屋克己、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 後天性血友病type2患者のトロンビン生成能低下の作用機序2007
- Author(s)
  松本智子、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] ヒト第VIII因子発現マウスES細胞を用いた血友病A細胞療法2007
- Author(s)
  粕田承吾、櫻井嘉彦、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 第VIII因子軽鎖C2は活性型第IX因子Glaドメインに結合する2007
- Author(s)
  添田哲弘、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Global assay using clot waveform and thrombin generation assays2007
- Author(s)
  Midori Shima
- Organizer
  XXIst Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Geneva
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007
- Author(s)
  Takeyama M, Nogami K, Shima M, et. al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 凝固波形およびトロンビン生成試験を用いた蕁麻疹患者における凝固能の検討2007
- Author(s)
  櫻井嘉彦、竹田知広、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Localization of fastor VIII interastive site within plasmin/plasminogen which is responseible for plasmin-catalyzed activation/inactivation of factor VIII2007
- Author(s)
  Nishiya K, Nogami K, Shima M, et. al
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 血友病Bに対する肝細胞移植治療の有効性〜マウスモデルにおける検討〜2007
- Author(s)
  辰巳公平、大橋一夫、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Role of direct interaction between factor C2 and factor IXa Gla domain in factor Xase complex.2007
- Author(s)
  Soeda T, Nogami K, Shima M, et. al
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Monitoring therapy to manage outcomes in hemophilia
- Author(s)
  Shima M
- Organizer
  5th East Asia Hemophilia Foundation
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] Successful long-term phenotypic correction of hemophilia A mice by multi-layerd endothelial cell sheet transplantation
- Author(s)
  Hideto Matsui, Masashi Noda, Rie Utoh, Kohei Tatsumi, Kazuo Ohashi, Midori Shima, Mitsuhiko Sugimoto, Teruo Okano
- Organizer
  The ASGCT 17th Annual Meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25293237
[Presentation] 血友病Ａイヌモデルを用いた自己細胞移植による新規血友病Ａ細胞治療法の開発検討
- Author(s)
  野田正志、松井英人、松成泰典、越智すなお、嶋　緑倫、中山正成、杉本充彦
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  札幌市
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25293237

1. TANAKA Ichiro (00201616)

# of Collaborated Projects : 4results

# of Collaborated Products : 6results
2. YOSHIOKA Akira (40106498)

# of Collaborated Projects : 3results

# of Collaborated Products : 2results
3. SUGIMOTO Mitsuhiko (80192128)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. NISHIMURA Takuya (00192253)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. NISHINO Masato (60164571)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. SAKURAI Yoshihiko (80347559)

# of Collaborated Projects : 2results

# of Collaborated Products : 19results
7. KEIJI Nogami (50326328)

# of Collaborated Projects : 2results

# of Collaborated Products : 38results
8. 中島充 (30183510)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. SHIBATA Masaru (50405388)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. MATSUI Hideto (00571027)

# of Collaborated Projects : 1results

# of Collaborated Products : 10results
11. HOTTA Akitsu (50578002)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
12. FUKUI Hiromu (20075104)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. TAKAHSHI Yukihiro (60142379)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. FUJIMURA Yoshihiro (80118033)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. MATSUMOTO Masanori (60316081)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. KORESAWA Mitsuhiko (60107703)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 中島祥介 (00142381)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 今中康丈 (70231165)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 山本正雅 (50150884)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 志村紀子 (60287480)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 西久保敏也 (20208169)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. 宮田茂樹 (20239411)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. 阪井利幸 (10175359)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. 澤本好克 (10264863)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. 中宏之 (40281761)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. 武山雅博 (30572010)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
27. 矢田弘史 (30635785)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
28. 松本智子 (80642678)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
29. 松下正

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
30. 大日向康秀

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
31. 志田泰明

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
32. 和田英夫

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Shima Modori 嶋 緑倫

嶋 緑倫 シマ ミドリ

SHIMA Midori 嶋 緑倫

Research Projects

Research Products

Co-Researchers

Studies on molecular pathology of hemophilia A and gain-of-function of FVIIIPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the next generation treatment for hemophilia A by autologous cell implantationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血友病A患者からモノクローナルインヒビターと抗イディオタイプ抗体の作製と抗原解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic study for establishment of novel antibody therapy for hemophilia A with an antibody enhancing factor VIII activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel antithrombotic strategy based on the functional regulation of factor VIII/VWF complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the clotting function by clot waveform analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vitro study for clotting function aid activation mechanism in the gene therapy for haemophilia APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study about factor VIII expression and immunological influence in the gene therapy of hemophilia APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDIES FOR TREATMENT OF HEMOPHILIA A WITH INHBITOR USING CANINIE SYSTEMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝細胞移植による血友病遺伝子治療に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular genetic study on patients with various types of von Willebrand disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunological, Biological and Molecular Genetic Study on Prenatal Diagnosis of Hemophilia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 血液疾患 診断・治療指針2015

Author(s)

Shima Modori 嶋緑倫

嶋緑倫シマミドリ

SHIMA Midori 嶋緑倫

[Book] 血液疾患　診断・治療指針2015

[Book] 今口の診断指針第6版2010

[Book] 血液凝固因子異常症,『内科学特装版』2006

[Book] 血友病,『三輪血液病学第3版』2006