Nogami Keiji 野上恵嗣

… Alternative Names

Researcher Number	50326328
Affiliation (Current)	2022: 奈良県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 奈良県立医科大学, 医学部, 教授 2011 – 2021: 奈良県立医科大学, 医学部, 准教授 2009 – 2010: Nara Medical University, 医学部, 講師 2007 – 2008: Nara Medical University, School of Medicine, Assistant lecturer 2007: 奈良県立医科大学, 医科部, 助教 2005 – 2006: Nara Medical Univ., Facult. Med., Assistant, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Hematology / Basic Section 55060:Emergency medicine-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 第VIII因子 / 血液凝固 / 活性型第VII因子 / 結合部位 / トロンビン / 外因系 / 活性化 / 活性化/不活化 / 組織因子 / 線溶系 … More Except Principal Investigator 第VIII因子 / 血友病 / インヒビター / 血友病A / 血液凝固 / 凝固因子 / 活性化プロテインC / 活性型プロテインC / プロテインS / 第IX因子 / 第X因子 / 凝固 / 血栓止血 / 蛋白質 / 血栓症 / 凝固第VIII因子 / 後天性凝固異常症 / 凝固機能評価 / 抗凝固 / 血流 / 血管内皮細胞 / 凝固波形 / 凝固機能 / トロンビン / 血液 / 内科 / 凝固線溶波形解析 / F8遺伝子変異 / 線溶 / 凝固第V因子 / APC抵抗性 / 小児 / 抑制メカニズム / 抗リン脂質抗体 / von willebrand factor / 活性化プロテインC抵抗性 / 第V因子 / ずり応力 / 血栓 / ヴォン･ヴィレブランド病 / フォン･ヴィレブランド病 / 血小板血栓形成 / 生理的血流 / フローチャンバー / 共焦点顕微鏡 / 血小板 / platelet thrombus formation / blood coagulation / physiologic blood flow / flow chamber / confocal microscopy / トロンビン生成 / 活性化 / 不活性化 / プラスミン / 組織因子 / 止血モニタリング / 凝固速度 / 凝固加速度 / clot waveform analysis / thrombin generation / hemophilia A / factor VIII / activation / inactivation / clotting function / plasmin / 活性化・不活性化 / 活性化第VII因子 / FVIII / 血管内皮 / shear stress / von Willebrand 因子 / 生理学 / 凝固波形解析 / 凝固異常症 / 凝固線溶波形 / 自動分析装置 / 出血症状 / 血液学 / 評価方法 / フォン・ウィルブランド因子 / 一塩基多型 / 遺伝子 / 細胞・組織 / 高機能型 / 遺伝子治療 / 活性型第IX因子 / 活性型第X因子 / リン脂質 / 小児科 / 分子異常症 / 小児がん / 播種性血管内凝固 / トロンビン・プラスミン生成試験 / トロンビンプラスミン生成試験 / 肝類洞閉塞症候群 / 血栓性微小血管障害症 / 脾臓微小環境 / ニッチ / 間葉系幹細胞 / 迅速診断法 Less

Basic research on development of novel therapeutic products for hemophilia A and thrombotic disorders based on the regulation of factor VIII function in the blood coagulationPrincipal Investigator
- Principal Investigator
  
  野上恵嗣
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
血友病Aインヒビター産生応答を制御する脾臓免疫ニッチの同定
- Principal Investigator
  
  小田朗永
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
血友病A患者・保因者の第Ⅷ因子遺伝子型に基づく病態解析と新規個別化治療戦略の開発
- Principal Investigator
  
  矢田弘史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
Development of a new rapid diagnostic method and early phase pathology analysis in coagulation fibrinolysis disorders
- Principal Investigator
  
  松本智子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tenri Health Care University
活性化プロテインCおよびプロテインS制御による安定化第VIII因子製剤の開発
- Principal Investigator
  
  武山雅博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nara Medical University
Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis
- Principal Investigator
  
  石原卓
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Development of novel therapeutic strategy based on hemostatic characteristics of FVIII in the patients with moderate/mild hemophilia A
- Principal Investigator
  
  Yada Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Identification of mechanism of FVIII-regulated blood coagulation and development on novel therapeutic drugs for hemophilia A and thrombotic diseasePrincipal Investigator
- Principal Investigator
  
  NOGAMI KEIJI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Regulation of factor VIII by activated protein C and protein S
- Principal Investigator
  
  Takeyama Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
The response of endothelial cells and the function of coagulation factor VIII under flow conditions
- Principal Investigator
  
  Shida Yasuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Produce of novel regimens that clarify coagulation inhibitory mechanisms for acquired coagulation disorders
- Principal Investigator
  
  Matsumoto Tomoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tenri Health Care University
  Nara Medical University
フォン・ウィルブランド因子D'D3ドメイン一塩基多型の分子生物学的解析
- Principal Investigator
  
  荻原建一
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on molecular pathology of hemophilia A and gain-of-function of FVIII
- Principal Investigator
  
  Midori Shima
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapyPrincipal Investigator
- Principal Investigator
  
  Nogami Keiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Basic research on establishment of a novel hemostatic treatment based on the hemostatic potential for mild hemophilia A with inhibitor
- Principal Investigator
  
  Yada Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Research for the regulation of factor VIII by activated protein C and protein S
- Principal Investigator
  
  TAKEYAMA MASAHIRO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Regulation of the function of endothelial cells by shear stress
- Principal Investigator
  
  shida yasuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Demonstration of global coagulation assays and the suppression mechanism about acquired coagulation disorders
- Principal Investigator
  
  Matsumoto Tomoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapyPrincipal Investigator
- Principal Investigator
  
  NOGAMI KEIJI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
第Ｖ因子の抗凝固機能と小児血栓性疾患との関連についての基礎的研究
- Principal Investigator
  
  荻原建一
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on the mechanisms of activation and inactivation of factor VIII : Applications of novel(anti-) coagulant therapyPrincipal Investigator
- Principal Investigator
  
  NOGAMI Keiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on the mechanisms of activation and inactivation of factor VIII : applications of novel coagulant and anticoagulant therapyPrincipal Investigator
- Principal Investigator
  
  NOGAMI Keiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Study on the clotting function by clot waveform analysis
- Principal Investigator
  
  SHIMA Midori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Clarification of mechanisms for thrombus formation under physiologic blood flow
- Principal Investigator
  
  SUGIMOTO Mitsuhiko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nara Medical University

[Book] 【新生児・小児の血栓症とDIC】血栓症の凝固機能と診断　小児がん関連の凝固障害症の研究から2019
- Author(s)
  石原　卓、野上　恵嗣
- Total Pages
  8
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19K08304
[Book] 【小児の救急・搬送医療】病態と疾患　血液・腫瘍　播種性血管内凝固(DIC)2019
- Author(s)
  石原　卓、野上　恵嗣
- Total Pages
  5
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-19K08304
[Book] 臨床に直結する血栓止血学2018
- Author(s)
  野上　恵嗣、松本　智子
- Total Pages
  686
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17K10127
[Book] 第VIII因子と第V因子の基礎と臨床新・血栓止血血管学　凝固と炎症2015
- Author(s)
  野上恵嗣
- Total Pages
  13
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-15K09663
[Book] 臨床に直結する血栓止血学-第VIII因子インヒビター、第IX因子インヒビター2013
- Author(s)
  松本　智子、　野上　恵嗣
- Total Pages
  2
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25461605
[Book] Annual Review血液20132013
- Author(s)
  野上恵嗣
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24591558
[Book] 第VIII因子と血液凝固制御―第VIII因子の機能・構造に関する最近の知見2012
- Author(s)
  野上恵嗣
- Total Pages
  6
- Publisher
  医学のあゆみ（医歯薬出版）
- Data Source
  KAKENHI-PROJECT-24591558
[Book] 血栓と循環「血液凝固反応の内因系と外因系は、現在どのように考えられているのですか?」2011
- Author(s)
  野上恵嗣
- Total Pages
  2
- Publisher
  メディカルレビュ社
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 血栓と循環「血栓症に関するQ&A」2011
- Author(s)
  野上恵嗣
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 小児科診療ガイド「von Willebrand病」2011
- Author(s)
  野上恵嗣、嶋緑倫
- Total Pages
  4
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 「小児の診療のしかた-あなたの疑問に答えます」出血傾向を認める患児のスクリーニング検査は何を行いますか?2011
- Author(s)
  野上恵嗣
- Publisher
  小児内科
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 血液疾患血液凝固異常小児科学レビュー2010
- Author(s)
  野上恵嗣, 嶋緑倫
- Total Pages
  111
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-21591370
[Book] Clinical and Laboratory Examination in Hemophilia Sysmex2010
- Author(s)
  Nogami Keiji, Shima Midori
- Publisher
  シスメックス
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 小児疾患診療のための病態生理2血友病.小児内科2009
- Author(s)
  野上恵嗣, 嶋緑倫
- Total Pages
  1124
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 血友病に対する適切な治療.臨床に直結する血液疾患診療のエビデンス2009
- Author(s)
  野上恵嗣, 嶋緑倫
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21591370
[Book] 血友病A-第VIII因子の分子生物学的診断の進歩. Annual Review 2009血液2009
- Author(s)
  野上恵嗣
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Coagulation and fibrinolysis balance in disseminated intravascular coagulation2021
- Author(s)
  Ohnishi Tomoko、Ishihara Takashi、Nogami Keiji
- Journal Title
  
  Pediatric International
  
  Volume: -
- DOI
  10.1111/ped.14684
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
[Journal Article] The C-terminal acidic region in the A1 domain of factor VIII facilitates thrombin-catalyzed activation and cleavage at Arg 3722021
- Author(s)
  Nakajima Y, Nogami K
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 19 Pages: 677-688
- DOI
  10.1111/jth.15201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07885
[Journal Article] Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg16892021
- Author(s)
  Nakajima Y, Minami H, Nogami K.
- Journal Title
  
  Thromb Haemost.
  
  Volume: -
- DOI
  10.1055/s-0041-1723996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07885
[Journal Article] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function2020
- Author(s)
  Onishi Tomoko、Nogami Keiji、Ishihara Takashi、Inoue Satoki、Kawaguchi Masahiko、Nishio Kenji、Fukushima Hidetada、Kobayashi Hiroshi、Amano Itsuto、Nishikubo Toshiya、Yamasaki Masaharu、Kasahara Masato、Shima Midori
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 120 Pages: 1257-1269
- DOI
  10.1055/s-0040-1713890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
[Journal Article] Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.2020
- Author(s)
  Yada K, Nogami K
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology.
  
  Volume: 40(5) Pages: 1148-1154
- DOI
  10.1161/atvbaha.120.312919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Emicizumab improves the stability and structure of fibrin clot derived from factor VIII‐deficient plasma, similar to the addition of factor VIII2020
- Author(s)
  Shimonishi Naruto、Nogami Keiji、Ogiwara Kenichi、Matsumoto Tomoko、Nakazawa Fumie、Soeda Tetsuhiro、Hirata Michinori、Arai Nobuo、Shima Midori
- Journal Title
  
  Haemophilia
  
  Volume: オンライン
- DOI
  10.1111/hae.13961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] Assessment of self‐/parent‐reported quality of life in Japanese children with haemophilia using the Japanese version of KIDSCREEN‐522020
- Author(s)
  Furuichi Yasuko、Nogami Keiji、Yada Koji、Nezu Satoko、Obayashi Kenji、Saeki Keigo、Kurumatani Norio、Nakajima Mitsuru、Kinoshita Seiji、Shima Midori
- Journal Title
  
  Haemophilia
  
  Volume: 26 Pages: 243-250
- DOI
  10.1111/hae.13945
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] lasma-derived factors VIIa and X mixtures (Byclot) significantly improve impairment of coagulant potential ex vivo in plasmas from acquired hemophilia A patients.2020
- Author(s)
  Ochi S, Takeyama M, Shima M, Nogami K.
- Journal Title
  
  Int J Hematol.
  
  Volume: -
- DOI
  10.1007/s12185-020-02837-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10125
[Journal Article] An anti‐factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A2020
- Author(s)
  Takeyama M, Nogami K, Matsumoto T, Noguchi-Sasaki M, Kitazawa T, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 18 Pages: 825-833
- DOI
  10.1111/jth.14746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10125
[Journal Article] Emicizumab Improves Ex Vivo Clotting Function in Patients with Mild/Moderate Hemophilia A2020
- Author(s)
  Nakajima Yuto、Nogami Keiji、Yada Koji、Furukawa Shoko、Noguchi-Sasaki Mariko、Hirata Michinori、Shima Midori
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: オンライン Pages: 968-976
- DOI
  10.1055/s-0040-1710315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-18K07798
[Journal Article] Evaluation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system2020
- Author(s)
  Nakajima Y, Nogami K, Yada K, Kawamura T, Ogiwara K, Furukawa S, Shimonishi N, Takeyama M, Shima M.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 111 Pages: 369-377
- DOI
  10.1007/s12185-019-02782-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10128
[Journal Article] Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease. Haemophilia.2019
- Author(s)
  Nakajima Y, Nogami K, Yada K , Ogiwara K, Furukawa S, Shimonishi N, Shima M.
- Journal Title
  
  Haemophilia
  
  Volume: 25(3)
- DOI
  10.1111/hae.13725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L‐asparaginase induction therapy in pediatric acute lymphoblastic leukemia2019
- Author(s)
  Ishihara Takashi、Nogami Keiji、Ochi Satoshi、Ishida Toshiaki、Kosaka Yoshiyuki、Sawada Akihisa、Inoue Masami、Osone Shinya、Imamura Toshihiko、Hosoi Hajime、Shima Midori
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: 67
- DOI
  10.1002/pbc.28016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-19K08326
[Journal Article] A case of moderate haemophilia A with inhibitor, carrying the p.R1800H mutation, complicated with juvenile idiopathic arthritis.2019
- Author(s)
  Yuka Kondo Yasuaki Shida Tomoaki Ishikawa Koji Yada Masahiro Takeyama Midori Shima Keiji Nogami
- Journal Title
  
  Haemophilia.
  
  Volume: 25(1) Pages: 51-54
- DOI
  10.1111/hae.13648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17K10125
[Journal Article] Global coagulation function assessed by rotational thromboelastometry predicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019
- Author(s)
  Yada K , Nogami K, Ogiwara K, Shida Y, Furukawa S, Yaoi H, Takeyama M, Kasai R,Shima M.
- Journal Title
  
  Int J Hematol.
  
  Volume: 110(4) Pages: 419-430
- DOI
  10.1007/s12185-019-02698-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10126
[Journal Article] A novel simultaneous clot‐fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders2019
- Author(s)
  Nogami K, Matsumoto T, Sasai K, Ogiwara K, Arai N, Shima M.
- Journal Title
  
  Br.J. Haematol
  
  Volume: 187 Pages: 518-529
- DOI
  10.1111/bjh.16111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127
[Journal Article] Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation2019
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Shima M.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 109 Pages: 390-401
- DOI
  10.1007/s12185-019-02611-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231
[Journal Article] Emicizumab, the bispecific antibody to factors IX/IXa and X/Xa, potentiates coagulation function in factor XI-deficient plasma in vitro.2019
- Author(s)
  Minami H, Nogami K, Yada K, Ogiwara K, Furukawa S, Soeda T, Kitazawa T, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 17 Pages: 126-137
- DOI
  10.1111/jth.14334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07885
[Journal Article] Dynamic evaluation of hemostasis in the acute phase of Kawasaki disease using comprehensive coagulation functional assays.2019
- Author(s)
  Yoshizawa H, Nogami K, Matsumoto T, Tsujii N, Sakai T, Takase T, Tanaka I, Shima M.
- Journal Title
  
  Thromb.Res.
  
  Volume: 174 Pages: 76-83
- DOI
  10.1016/j.thromres.2018.12.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15684, KAKENHI-PROJECT-17K10127
[Journal Article] Spotlight on emicizumab in the management of hemophilia A:patient selection and special considerations.2019
- Author(s)
  Yada K , Nogami K
- Journal Title
  
  Journal of blood medicine
  
  Volume: 10 Pages: 171-181
- DOI
  10.2147/jbm.s175952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation2019
- Author(s)
  Ishihara Takashi、Nogami Keiji、Onishi Tomoko、Ogiwara Kenichi、Ochi Satoshi、Yamazaki Masaharu、Shima Midori
- Journal Title
  
  Pediatrics International
  
  Volume: 61 Pages: 872-881
- DOI
  10.1111/ped.13919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08304
[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor.2018
- Author(s)
  Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
- Journal Title
  
  British Journal of Haematology
  
  Volume: ahead of printing Pages: 528-536
- DOI
  10.1111/bjh.15209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-18K07885
[Journal Article] New therapies using nonfactor products for patients with hemophilia and inhibitors2018
- Author(s)
  Nogami Keiji、Shima Midori
- Journal Title
  
  Blood
  
  Volume: 133 Pages: 399-406
- DOI
  10.1182/blood-2018-07-820712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] Routine measurements of factor VIII activity and inhibitor titer in the presence of emicizumab utilizing anti-idiotype monoclonal antibodies.2018
- Author(s)
  Nogami K, Soeda T, Matsumoto T, Kawabe Y, Kitazawa T, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 16(7) Pages: 1383-1390
- DOI
  10.1111/jth.14135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07885
[Journal Article] Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation.2018
- Author(s)
  Narazaki T, Haji S, Nakashima Y, Tsukamoto Y, Tsuda M, Takamatsu A, Ohno H, Matsushima T, Matsumoto T, Nogami K, Shima M, Shiratsuchi M, Ogawa Y
- Journal Title
  
  Int J Hematol
  
  Volume: 108(3) Pages: 335-338
- DOI
  10.1007/s12185-018-2441-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10127
[Journal Article] Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.2018
- Author(s)
  Takeyama M, Nogami K, Sasai K, Furukawa S, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 118 Pages: 830-841
- DOI
  10.1055/s-0038-1637745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07885
[Journal Article] Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V2018
- Author(s)
  Yada Koji、Nogami Keiji、Shinozawa Keiko、Kitazawa Takehisa、Hattori Kunihiro、Amano Kagehiro、Fukutake Katsuyuki、Shima Midori
- Journal Title
  
  British Journal of Haematology
  
  Volume: 183 Pages: 257-266
- DOI
  10.1111/bjh.15525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] Orthotopic liver transplantation for haemophilia A may not always lead to a phenotypic cure of haemophilia A: A case report2018
- Author(s)
  Suzuki Y, Kakisaka K, Matsumoto T, Nogami K, Katagiri H, Takahara T, Takikawa Y
- Journal Title
  
  Haemophilia
  
  Volume: 24(6)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10127
[Journal Article] First report of real-time monitoring of coagulation function potential and IgG subtype of anti-FVIII autoantibodies in a child with acquired hemophilia A associated with streptococcal infection and amoxicillin2018
- Author(s)
  Takeyama M, Nogami K, Kajimoto T, Ogiwara K, Matsumoto T, Shima M
- Journal Title
  
  Int J Hematol
  
  Volume: 107(1) Pages: 112-116
- DOI
  10.1007/s12185-017-2273-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10127
[Journal Article] The factor VIII heavy chain improves emicizumab-tenase assembly to enhance the factor VIII-mimicking cofactor activity.2018
- Author(s)
  Minami H, Nogami K, Soeda T, Kitazawa T, Hattori K, Shima M.
- Journal Title
  
  Thrombosis Research
  
  Volume: 166 Pages: 77-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07885
[Journal Article] Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody emicizumab2018
- Author(s)
  Nogami K, Matsumoto T, Tabuchi Y, Soeda T, Arai N, Kitazawa T, Shima M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 未定 Pages: 1078-1088
- DOI
  10.1111/jth.14022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07885
[Journal Article] Potentially life-threatening coagulopathy associated with simultaneous reduction in coagulation and fibrinolytic function in pediatric acute leukemia after hematopoietic stem-cell transplantation.2017
- Author(s)
  Ishihara T, Nogami K , Matsumoto T, Nomura A, Takeshita Y, Ochi S, Shima M
- Journal Title
  
  International Jurnal of Hematology
  
  Volume: 106(1) Pages: 126-134
- DOI
  10.1007/s12185-017-2213-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10127
[Journal Article] Successful prophylaxis using activated prothrombin complex concentrates (aPCC) in a severe haemophilia A patient with inhibitor previously unresponsive to on-demand daily infusions of aPCC.2017
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Shima M.
- Journal Title
  
  Haemophilia
  
  Volume: 23
- DOI
  10.1111/hae.13310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664
[Journal Article] A combined approach using global coagulation assays quickly differentiates coagulation disorders with prolonged aPTT and low levels of FVIII activity.2017
- Author(s)
  Tomoko Matsumoto, Keiji Nogami, Midori Shima
- Journal Title
  
  International Journal of Hematology
  
  Volume: 105(2) Pages: 174-183
- DOI
  10.1007/s12185-016-2108-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-17H04231
[Journal Article] Role of red blood cells in the anemia-associated bleeding under high shear conditions.2017
- Author(s)
  H. Yaoi, Y. Shida,, K. Ogiwara, K. Hosokawa, M. Shima and K. Nogami
- Journal Title
  
  Haemophilia
  
  Volume: - Pages: 750-758
- DOI
  10.1111/hae.13252
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593, KAKENHI-PROJECT-17K10126
[Journal Article] Long-term safety and efficacy of emicizumab in a phase 1/2 study in patients with hemophilia A with or without inhibitors.2017
- Author(s)
  Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Kasai R, Yoneyama K, Yoshida H, Nogami K.
- Journal Title
  
  Blood Advances
  
  Volume: 1(22) Pages: 1891-1899
- DOI
  10.1182/bloodadvances.2017006684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663
[Journal Article] Clot waveform analysis using CS-2000i distinguishes between very low and absent levels of factor VIII activity in patients with severe hemophilia A2017
- Author(s)
  Tomoko Matsumoto, Keiji Nogami, Yuka Tabuchi, Koji Yada, Kenichi Ogiwara, Hiroshi Kurono, Nobuo Arai, Midori Shima
- Journal Title
  
  Haemophilia
  
  Volume: 23(5)
- DOI
  10.1111/hae.13266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10127
[Journal Article] A new parameter in the thrombin generation assay, mean velocity to peak thrombin, reflects factor VIII activity in patients with haemophilia A2016
- Author(s)
  Takeyama M, Nogami K, Shima M.
- Journal Title
  
  Haemophilia
  
  Volume: 22(5) Pages: 474-477
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016
- Author(s)
  Nogami K1, Ogiwara K1, Yada K1, Shida Y1, Takeyama, Yaoi　H, Minami H, Furukawa S, Hosokawa K, Shima M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 14 Pages: 667-74
- DOI
  10.1111/jth.13273
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016
- Author(s)
  Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, Minami H, Furukawa S, Hosokawa K, Shima M.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 14(4) Pages: 667-674
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] The utility of thromboelastography in inherited and acquired bleeding disorders.2016
- Author(s)
  Keiji Nogami
- Journal Title
  
  British Journal of Haematology
  
  Volume: 174(4) Pages: 503-514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016
- Author(s)
  Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, MinamiH, Furukawa S, Hosokawa K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 14(4) Pages: 667-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] Successful haemostatic management of replacement of the ascending aorta for type A acute aortic dissection in a patient with mild haemophilia B2016
- Author(s)
  Takeyama M, Nogami K, Shida Y, Yada K, Hirose T, Hayata Y, Tabayashi N, Taniguchi S, Akasaki Y, Kawaraguchi Y, Kawaguchi M, Shima M
- Journal Title
  
  Haemophilia
  
  Volume: Jan 29
- DOI
  10.1111/hae.12879
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] トロンビン生成試験（thrombin generation test）2016
- Author(s)
  松本　智子、野上　恵嗣
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 6(1) Pages: 55-61
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] The utility of VWF multimer analysis in response to the desmopressin administration for the diagnosis of severe type 1 von Willebrand disease.2016
- Author(s)
  Takeyama M, Nogami K, Onaka M, Yada K, Shida Y, Shima M
- Journal Title
  
  Haemophilia
  
  Volume: Jan 29
- DOI
  10.1111/hae.12874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] フォン・ヴィレブランド病の病態と診療2015
- Author(s)
  志田　泰明,　野上恵嗣
- Journal Title
  
  日本小児血液・がん学会雑誌
  
  Volume: 52（1） Pages: 1-9
- NAID
  40020456048
- Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] FVIIIの生合成およびフォン･ヴィレブランド因子との相互作用に関する最新の知見2015
- Author(s)
  志田　泰明,　野上恵嗣
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 26（1） Pages: 49-56
- NAID
  130004847363
- Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Optimization of the automated, CS-2000i method for measuring low levels of von Willebrand factor ristocetin cofactor activity (VWF:RCo).2015
- Author(s)
  Nogami K, Shinozawa K, Ogiwara K, Matsumoto T, Amano K, Fukutake K, Shima M.
- Journal Title
  
  Int J Hematol
  
  Volume: 10; 123(15) Pages: 126-132
- DOI
  10.1007/s12185-014-1720-x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461605, KAKENHI-PROJECT-26461593
[Journal Article] 血栓止血性疾患の遺伝子診断―出血性疾患2015
- Author(s)
  矢田弘史, 野上恵嗣
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 26 Pages: 513-517
- NAID
  130005102998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] プロテインCおよびプロテインSによる凝固第VIII因子の制御機構の解明および新規血友病治療製剤への応用2015
- Author(s)
  武山雅博、野上恵嗣
- Journal Title
  
  母子健康協会小児医学助成研究報告書
  
  Volume: 1 Pages: 12-13
- Data Source
  KAKENHI-PROJECT-26461592
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 13 Pages: 1843-1853
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
- Journal Title
  
  Journal of Thrombosis Haemostasis
  
  Volume: 13 Pages: 1843-1853
- DOI
  10.1111/jth.13118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
[Journal Article] Phenotypic heterogeneity of hemostasis in severe hemophilia2015
- Author(s)
  Nogami K, Shima M.
- Journal Title
  
  Seminars in Thrombosis and Hemostasis
  
  Volume: 41 Pages: 826-831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] Comprehensive evaluation of haemostatic function in von Willebrand disease patients using a microchip-based flow chamber system.2015
- Author(s)
  Ogiwara K1, Nogami K, Hosokawa K, Ohnishi T, Matsumoto T, Shima M
- Journal Title
  
  Haemophilia
  
  Volume: 21(1) Pages: 71-80
- DOI
  10.1111/hae.12610
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 13 Pages: 1279-1284
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09663
[Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 13 Pages: 1279-1284
- DOI
  10.1111/jth.12987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor.2014
- Author(s)
  Ogiwara K, Nogami K, Matsumoto T, Shima M
- Journal Title
  
  Int J Hematol.
  
  Volume: 99 Pages: 577-587
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] Novel FV mutation (W1920R, FVNara) associated with serious deep vein thrombosis and more potent APC resistance relative to FVLeiden2014
- Author(s)
  Nogami K, Shinozawa K, Ogiwara K, Matsumoto T, Amano K, Fukutake K, Shima M.
- Journal Title
  
  Blood
  
  Volume: 2420-8 Pages: 2420-8
- DOI
  10.1182/blood-2013-10-530089
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] フォン･ヴィレブランド病の分子生物学的診断と診療への応用2014
- Author(s)
  志田　泰明,　野上恵嗣
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25(4)
- NAID
  130004687765
- Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Coagulation function and mechanisms in various clinical phenotypes of patients with acquired factor V inhibitors2014
- Author(s)
  Matsumoto T, Nogami K, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 12(9) Pages: 1503-12
- DOI
  10.1111/jth.12660
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] The first case of int1h-related inversion in Japanese haemophilia A patients2014
- Author(s)
  Yada K, Nogami K, Kawamura T, Minami H, Shima M
- Journal Title
  
  Haemophilia
  
  Volume: 20(6)
- DOI
  10.1111/hae.12509
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860878, KAKENHI-PROJECT-26461593
[Journal Article] Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A2014
- Author(s)
  Muto A, Yoshihashi K, Takeda M, Kitazawa T, Soeda T, Igawa T, Sampei Z, Kuramochi T, Sakamoto A, Haraya K, Adachi K, Kawabe Y, Nogami K, Shima M, Hattori K.
- Journal Title
  
  Blood
  
  Volume: 124(20) Pages: 3165-71
- DOI
  10.1182/blood-2014-07-585737
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis2014
- Author(s)
  Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 12(3) Pages: 355-62
- DOI
  10.1111/jth.12488
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461593
[Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis.2014
- Author(s)
  Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 12 Pages: 355-362
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] 血友病A の分子病態の進歩 - 第VIII 因子構造・機能からみた病態2014
- Author(s)
  野上恵嗣
- Journal Title
  
  日本小児血液・がん学会雑誌
  
  Volume: 51 Pages: 452-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] 1.症例から学ぶ止血凝固検査2014
- Author(s)
  松本　智子、野上　恵嗣
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 15（2） Pages: 233-239
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] 血液凝固の動的把握と血友病診療の進歩2014
- Author(s)
  野上恵嗣
- Journal Title
  
  血栓止血誌
  
  Volume: ２５ Pages: 371-379
- NAID
  130004847325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor2014
- Author(s)
  Ogiwara K, Nogami K, Matsumoto T, Shima M.
- Journal Title
  
  Int J Hematol
  
  Volume: 99 Pages: 577-587
- DOI
  10.1007/s12185-014-1572-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461605, KAKENHI-PROJECT-26461593
[Journal Article] Coagulation function and mechanisms in various clinical phenotypes of patients with acquired factor V inhibitors.2014
- Author(s)
  Matsumoto T, Nogami K, Shima M.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 12 Pages: 1503-1512
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis.2014
- Author(s)
  Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 12(3) Pages: 355-362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] 後天性凝固因子インヒビターの基礎と病態2013
- Author(s)
  野上恵嗣
- Journal Title
  
  臨床血液
  
  Volume: 54(10) Pages: 361-368
- NAID
  10031196336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] Different factor VIII neutralizing effects on　anti-factor VIII inhibitor antibodies associated with epitope specificity and von　Willebrand factor.2013
- Author(s)
  Yada K, Nogami K, Shima M.
- Journal Title
  
  British Jornal of Haematology
  
  Volume: 163(1) Pages: 104-111
- DOI
  10.1111/bjh.12473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.2013
- Author(s)
  Yada K, Nogami K, Ogiwara K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 11(5) Pages: 902-910
- DOI
  10.1111/jth.12197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis.2013
- Author(s)
  Matsumoto T, Nogami K, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 110 Pages: 761-768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] 新規凝固機能検査による評価；T-TAS®とトロンビン生成試験(TGT)の基本と臨床2013
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫。
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 第14巻　第3号 Pages: 365-372
- Data Source
  KAKENHI-PROJECT-25461605
[Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis.2013
- Author(s)
  Matsumoto T, Nogami K, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 110(4) Pages: 761-768
- DOI
  10.1160/th13-04-0345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X.2013
- Author(s)
  Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 109(6) Pages: 1007-1015
- DOI
  10.1160/th12-10-0762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] A putative inhibitory mechanism in the tenase complex responsible for loss of coagulation function in acquired haemophilia A patients with anti-C2 autoantibodies.2012
- Author(s)
  Matsumoto T, Nogami K, Ogiwara K, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 107 Pages: 288-301
- DOI
  10.1160/th11-05-0331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558
[Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII2011
- Author(s)
  Yada K, Nogami K, 他3名
- Journal Title
  
  Thromb Haemost
  
  Volume: 105 Pages: 989-98
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)2011
- Author(s)
  Nogami K, Ogiwara K, et al
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 105 Pages: 968-980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)2011
- Author(s)
  Nogami K, Ogiwara K, 他4名
- Journal Title
  
  Thromb Haemost
  
  Volume: 105 Pages: 968-80
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII2011
- Author(s)
  Yada K, Nogami K (corresponding author), et al
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 105 Pages: 989-998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Interactions between residues 2228-2240 within factor VIIIa C2 domain and factor IXa Gla domain contribute to propagation of clot formation2011
- Author(s)
  Soeda T, Nogami K, 他2名
- Journal Title
  
  Thromb Haemost
  
  Volume: 106 Pages: 893-900
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Interactions between residues 2228-2240 within factor VIIIa C2 domain and factor IXa Gla domain contribute to propagation of clot formation2011
- Author(s)
  Soeda T, Nogami K,(corresponding author), et al
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 106 Pages: 893-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalyzed activation and inactivation of factor VIII2011
- Author(s)
  Yada K, Nogami K (corresponding author), et al.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Factor VIII activation by factor VIIa analog (V158D/E296V/M298Q) in tissue factor-independent mechanisms2011
- Author(s)
  Ogiwara K, Nogami K (corresponding author), et al
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 106 Pages: 665-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Factor VIII activation by factor VIIa analog(V158D/E296V/M298Q) in tissue factor independent mechanisms2011
- Author(s)
  Ogiwara K, Nogami K, 他1名
- Journal Title
  
  Thromb Haemost
  
  Volume: 106 Pages: 665-74
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010
- Author(s)
  Nishiya K, Nogami K (corresponding author), et al.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 104 Pages: 105-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010
- Author(s)
  Soeda T, Nogami K, 他3名
- Journal Title
  
  J Thromb Haemost
  
  Volume: 8 Pages: 2494-503
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Determination of a factor VIII interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010
- Author(s)
  Nishiya K, Nogami K, 他5名
- Journal Title
  
  Thromb Haemost
  
  Volume: 104 Pages: 105-17
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Characterization of an antibody specific for coagulation factor VIII that enhances factor VIII(a)activity2010
- Author(s)
  Takeyama M, Nogami K(corresponding author), et al.
- Journal Title
  
  Thrombosis and Haemostasis 103
  
  Pages: 94-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010
- Author(s)
  Soeda T, Nogami K (correspondingauthor), et al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 8 Pages: 2494-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalyzed activation and inactivation of factor VIII(a)2010
- Author(s)
  Nishiya K, Nogami K(corresponding author), et al.
- Journal Title
  
  Thrombosis and Haemostasis (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Plasmin-induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010
- Author(s)
  Ogiwara K, Nogami K (corresponding author), et al.
- Journal Title
  
  Blood Coagulation and Fibrinolysis
  
  Volume: 21 Pages: 768-776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Plasmin induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010
- Author(s)
  Ogiwara K, Nogami K, 他2名
- Journal Title
  
  Blood Coagul Fibrinolysis
  
  Volume: 21 Pages: 568-76
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010
- Author(s)
  Takeyama M, Nogami K, 他5名
- Journal Title
  
  Thromb Haemost
  
  Volume: 103 Pages: 94-102
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex2009
- Author(s)
  Soeda T, Nogami K, et.al.(他6名)
- Journal Title
  
  J Biol Chem 284
  
  Pages: 3379-88
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A2009
- Author(s)
  Matsumoto T, Nogami K, 他2名
- Journal Title
  
  Int J Hematol
  
  Volume: 90 Pages: 576-82
- NAID
  10026109911
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor xase complex.2009
- Author(s)
  Soeda T, Nogami K. (corresponding author), et al.
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 3379-3388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a protein S interactive site within the A2 domain of the factor VIII heavy chain2009
- Author(s)
  Takeyama M, Nogami K, 他3名
- Journal Title
  
  Thromb Haemost
  
  Volume: 102 Pages: 645-55
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] von Willebrand factor protects the Ca2+-dependent structure of the factor VIII light chain2009
- Author(s)
  Takeyama M, Nogami K(corresponding author), et al.
- Journal Title
  
  British Journal of Haemotology 146
  
  Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009
- Author(s)
  Nogami K. (1^<st> author), et al.
- Journal Title
  
  The Journal of Biological Chemistry In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a protein S-interactive site within the A2 domain of the factor VIII heavy chain2009
- Author(s)
  Takeyama M, Nogami K(corresponding author), et al.
- Journal Title
  
  Thrombosis and Haemostasis 102
  
  Pages: 645-655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A2009
- Author(s)
  Matsumoto T, Nogami K(corresponding author), et al.
- Journal Title
  
  International Journal of Haemotology 90
  
  Pages: 576-582
- NAID
  10026109911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] The factor VIIIa C2 domain(residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex2009
- Author(s)
  Soeda T, Nogami K, 他6名
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 3379-88
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009
- Author(s)
  Nogami K, Nishiya K, et.al.(他5名)
- Journal Title
  
  J Biol Chem 284
  
  Pages: 6934-45
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009
- Author(s)
  Nogami K, 他6名
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 6934-45
- Data Source
  KAKENHI-PROJECT-21591370
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008
- Author(s)
  Nogami K. (1^<st> author), et al.
- Journal Title
  
  Biochemical Biochimica et Acta 1784
  
  Pages: 753-763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Protein S down-regulates factor Xase activity independent of activated protein C : specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa2008
- Author(s)
  Takeyama M, Nogami K. (corresponding author), et al.
- Journal Title
  
  British Journal of Hematology 143
  
  Pages: 409-420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg3722008
- Author(s)
  Nogami K, Saenko EL, et.al.(他4名)
- Journal Title
  
  Br J Haematol 140
  
  Pages: 433-43
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption2008
- Author(s)
  Takeyama M, Nogami K, et.al.(他5名)
- Journal Title
  
  Br J Haematol 142
  
  Pages: 962-70
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008
- Author(s)
  Nogami K, Shima M, et.al.(他5名)
- Journal Title
  
  Biochim Biophys Acta 1784
  
  Pages: 753-63
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a thrombin-interactive site with in the factor VIII A2 domain that is responsible for the cleavage at Arg3722008
- Author(s)
  Nogami K.(1^<st> author), et. al.
- Journal Title
  
  British Journal of Hematology 140
  
  Pages: 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a plasmin-interactive site with in the A2 domain of the factor VIII heavy chain2008
- Author(s)
  Nogami K.(1^<st> author), et. al.
- Journal Title
  
  Biochemical Biochimica et Acta In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption2008
- Author(s)
  Takeyama M, Nogami K. (corresponding author), et al.
- Journal Title
  
  British Journal of Hematology 142
  
  Pages: 962-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008
- Author(s)
  Nogami K, Nishiya K, Shima M, et. al.
- Journal Title
  
  Biochimica et Biophysica Acta (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2008
- Author(s)
  Nogami K, Yoshioka A, Shima M, et. al.
- Journal Title
  
  Britishi Journal of Haematology 140
  
  Pages: 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Protein S down-regulates factor Xase activity independent of activated protein C : specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa2008
- Author(s)
  Takeyama M, Nogami K, et.al.(他5名)
- Journal Title
  
  Br J Haematol 143
  
  Pages: 409-20
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Identification of a thrombin-interactive site within the factor VIII A2 domain that is responsible for the cleavage at Arg3722008
- Author(s)
  Nogami K. (1^<st> author), et al.
- Journal Title
  
  British Journal of Hematology 140
  
  Pages: 433-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII : a crucial role for proteolytic cleavage at Arg^<336> responsible for plasmin-catalyzed factor VIII inactivation2007
- Author(s)
  Nogami K, Shima M, et al.
- Journal Title
  
  Journal of Biological Chemistry 282(8)
  
  Pages: 5287-5295
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M et.al.(他4名)
- Journal Title
  
  Int J Hematol 85
  
  Pages: 317-22
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] 血友病Aの分子病態. 第VIII因子の分子構造および機能の最近の知見2007
- Author(s)
  野上恵嗣
- Journal Title
  
  血栓止血誌 19
  
  Pages: 779-87
- NAID
  10026116902
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid,and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages: 317-322
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII : A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 5287-5295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 doma in2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama M, Tanaka I, Yoshioka A.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages: 317-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007
- Author(s)
  Nogami K, Saenko EL, Takeyama M, Giddings JC, Yoshioka A, Shima M.
- Journal Title
  
  British Journal of Haematology 140
  
  Pages: 433-443
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007
- Author(s)
  Nogami K, Saenko, EL, Takeyama M, Shima M, et. al.
- Journal Title
  
  British Journal of Haematology 140
  
  Pages: 433-443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII: A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007
- Author(s)
  Nogami K, Shima M, Matsumoto T, Nishiya K, Tanaka I, Yoshioka A.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 5287-5295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Mechanisms of plasmin-catallyzed inzctivation of fctor VIII:a crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007
- Author(s)
  Nogami K. (1^<st> author), et. al.
- Journal Title
  
  The Journal of Biological Chemistry 282
  
  Pages: 5287-5295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII:A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007
- Author(s)
  Nogami K, Shima M, Matsumoto T, et. al.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 5287-5295
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Heparin-induced inhibitory effets of a prothrombin complex concentrate on global tests of haemostasis2007
- Author(s)
  Takeyama M, Sakurai Y, shima M Matsumoto T, Nogami K, et. al.
- Journal Title
  
  Blood Coagulation & Fibrinolysis 18
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, et al.
- Journal Title
  
  International Journal of Hematology (in press)
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies with in the factor VIII C2 domain2007
- Author(s)
  Nogami K.(1^<st> author), et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages: 317-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII2007
- Author(s)
  Nogami K, Shima M, et.al.(他4名)
- Journal Title
  
  J Biol Chem 282
  
  Pages: 5287-95
- Data Source
  KAKENHI-PROJECT-19591264
[Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007
- Author(s)
  Nogami K, Shima M, Giddings JC, Takeyama, et. al.
- Journal Title
  
  International Journal of Hematology 85
  
  Pages: 317-322
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for throm bin-catalyzed factor V activation2006
- Author(s)
  Suzuki H, Shima M, Nogami K, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4
  
  Pages: 1354-1360
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for thrombin-catalyzed factor V activation2006
- Author(s)
  Suzuki H, Shima M, Nogami K, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 4
  
  Pages: 1354-1360
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain
- Author(s)
  Nogami K, Nishiya K, Shima M, et. al.
- Journal Title
  
  Biochimica et Biophysica Acta (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Patent] 血液検体の凝固能の評価方法、並びにその方法に用いるための試薬、試薬キットおよび装置2015
- Inventor(s)
  嶋緑倫、野上恵嗣、松本智子、北沢剛久、添田哲弘、池田有香
- Industrial Property Rights Holder
  嶋緑倫、野上恵嗣、松本智子、北沢剛久、添田哲弘、池田有香
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-24
- Acquisition Date
  2016-03-30
- Data Source
  KAKENHI-PROJECT-25461605
[Patent] 血液凝固第VIII因子の活性を促進する抗体2006
- Inventor(s)
  武山雅博、野上恵嗣、嶋緑倫、鈴木司
- Industrial Property Rights Holder
  中外製薬
- Industrial Property Number
  2006-235776
- Filing Date
  2006-08-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Update on factor (F)VIII structure and function-related hemostatic coagulation and its regulatory mechanism(s)2020
- Author(s)
  Nogami K
- Organizer
  82th Annual Meeting of the Japanese Society of Hematology
- Invited
- Data Source
  KAKENHI-PROJECT-18K07885
[Presentation] A new global assay for detection of protein C pathway-associated thrombophilia using thrombomodulin-mediated clot waveform analysis2020
- Author(s)
  Naoki Hashimoto, Kenichi Ogiwara, Keiji Nogami, Midori Shima
- Organizer
  International Society on Thrombosis and Hemostasis 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10128
[Presentation] 市販後エミシズマブを導入した血友病A小児13例の臨床的検討2019
- Author(s)
  水町邦義, 荻原建一, 古川晶子, 矢田弘史, 武山雅博, 野上恵嗣, 嶋緑倫
- Organizer
  第６１回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 後天性血友病A患者の治療寛解後にみられる第VIII因子上昇に関する包括的凝固機能解析2019
- Author(s)
  柴崎史隆. 武山雅博, 野上恵嗣, 笹井香那, 嶋緑倫
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] Residues 1680-1684 in the A3 domain of factor VIII contain a novel thrombin-interactive site responsible for proteolysitc clevage at Arg16892019
- Author(s)
  Nakajima Y, Nogami K, Minami H, Sasai K, Shima M
- Organizer
  61th American Society of Hematology Annual meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Quantitative evaluation of fibrin clot strcture formed in the presence of emicizumab using scanning electron microscope2019
- Author(s)
  Shimonishi N, Nogami K, Ogiwara K, Matsumoto T, Nakazawa F, Noguchi-Sasaki M, Hirata M, Arai N, Shima M
- Organizer
  International Society on Thrombosis and Hemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] トロンビン・プラスミン生成の低下がみられた肝類洞閉塞症候群（SOS）の1例2019
- Author(s)
  石原　卓、野上　恵嗣、越智　聡史、水町　邦義、大西　智子、嶋　緑倫
- Organizer
  第41回日本造血細胞移植学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] インヒビター保有血友病A患者における活性型第VII因子による凝固改善に必要な第X因子に関する定量的検討2019
- Author(s)
  矢田弘史、野上恵嗣、坪田夏芽、嶋　緑倫
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] Novel measurement of factor VIII by template matching method using weighed center on APTT clot waveform2019
- Author(s)
  Shimonishi N, Ogiwara K, Nogami K, Oda Y, Kawabe T, Okazaki S, Shima M
- Organizer
  International Society on Thrombosis and Hemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Additive effect on the global clotting function in moderate/mild hemophilia A by addition of emicizumab, evaluated by clot waveform analysis2019
- Author(s)
  Nakajima Y, Nogami K, Yada K, Furukawa S, Noguchi M, Hirata M, Shima M
- Organizer
  International Society on Thrombosis and Hemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Novel Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg16892019
- Author(s)
  Nakajima Y, Nogami K, Minami H, Sasai K, Shima M
- Organizer
  the 61st ASH Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07885
[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019
- Author(s)
  大西　智子、野上　恵嗣、伊藤　陽子、大前　隆志、石原　卓、嶋　緑倫
- Organizer
  第122回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS)のフィブリン形成能低下とその脆弱性2018
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第 40 回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] Current and Future Prospects on the Hemostatic Treatment for Hemophilia2018
- Author(s)
  Keiji Nogami
- Organizer
  Taiwan Society of Blood and Marrow Tranplantation Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07885
[Presentation] Utility of converted factor VIII activity by thrombin generation assay for evaluation of clotting function among hemophilia A carriers2018
- Author(s)
  Nogami K, Kawamura T, Shima M, Yada K
- Organizer
  World Federation of Hemophilia 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] A bispecific antibody, Emicizumab (HEMLIBRA), mimicking factor VIII: A novel alternative therapy for patients with hemophilia A with inhibitor2018
- Author(s)
  Keiji Nogami
- Organizer
  80th Annual Meeting of the Japanese Society of Hematology
- Invited
- Data Source
  KAKENHI-PROJECT-18K07885
[Presentation] 包括的ダイナミック解析による先天性血友病A患者の凝固線溶動態の特性2018
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第61回　日本臨床検査医学会近畿支部総会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018
- Author(s)
  Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
- Organizer
  ６０thAmerican Society of Hematology　Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 各種APTT試薬を用いた凝固線溶動態評価による新規凝固因子欠乏血漿の分類2018
- Author(s)
  松本　智子、野上　恵嗣、辻本　藍子、笹井　香那、荻原　建一、竹中　亜利沙、新井　信夫、篠原　翔、田渕　有香、嶋　緑倫
- Organizer
  第19回　日本検査血液学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] 4.A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018
- Author(s)
  Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
- Organizer
  60th American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] Impaired thrombus formation of von Willebrand Disease under high shear flow condition is improved by factor FVIIIa mimetic bispecific antibody(emicizumab)2018
- Author(s)
  Hiroaki Yaoi, Yasuaki Shida, Keiji Nogami, Takehisa Kitazawa, Midori Shima
- Organizer
  world federation of hemophilia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] 1.Bドメイン除去(BDD)第VIII 因子(FVIII)においてFVIIa/TF 惹起FVIII 不活化は遷延される2018
- Author(s)
  中島　由翔，矢田弘史，野上恵嗣，嶋緑倫
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] A novel hemostatic monitoring with simultaneous clot-fibrinolysis waveform analysis for hemophilia A2018
- Author(s)
  Aiko Tsujimoto, Keiji Nogami, Tomoko Matsumoto, Kenichi Ogiwara, Takehisa Kitazawa, Midori Shima
- Organizer
  第80回　日本血液学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] 第VIII 因子A3 残基1663-1666 にArg1689開裂を制御するトロンビン結合領域が存在する2018
- Author(s)
  南　　博明，野上　恵嗣，笹井　香那，古川　晶子，武山　雅博，嶋　　緑倫
- Organizer
  第40回日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] A novel mechanism of factor VIIa/Tissue Factor (TF)-catalyzed activation and inactivation of B-domain-deleted Factor VIII in the early initiation phases of coagulation2018
- Author(s)
  Yuito Nakajima, Keiji Nogami, Koji Yada, Midori Shima
- Organizer
  60th Annual Meeting of the American Society of Hematology
- Data Source
  KAKENHI-PROJECT-18K07885
[Presentation] R2159C 変異FVIII(FVIII-Ise)はC2 ドメインの構造機能変化をきたしている2018
- Author(s)
  越智　聡史，武山　雅博，野上　恵嗣，嶋　　緑倫
- Organizer
  第40回日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] A new classification of DIC based on the coagulation/fibrinolysis dynamics2018
- Author(s)
  Tomoko Onishi, Keiji Nogami, Tomoko Matsumoto, Takashi Ishihara, Midori Shima
- Organizer
  第80回　日本血液学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] VWD 各病型におけるEmicizumab の高ずり応力下での止血効果2018
- Author(s)
  矢追博章，志田泰明，野上恵嗣，北沢剛久，嶋緑倫
- Organizer
  第40回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] 第VIII因子A3ドメイン上の新規第IXa因子結合部位の同定2018
- Author(s)
  武山　雅博, 野上　恵嗣, 笹井　香那, 嶋　　緑倫
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site2018
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Kana Sasai, Midori Shima
- Organizer
  ６０thAmerican Society of Hematology　Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Mode of enhancement in the global hemostatic potentials with concomitant use of bypassing agents and emicizumab in hemophilia A patients with inhibitor evaluated by ROTEM.2017
- Author(s)
  Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
- Organizer
  The XXVI Congress of the ISTH and 63rd Annual Scientific and Standardization Committee (SSC) Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] FVIIIa Mimicking Bispecific Antibody (emicizumab) Improved Thrombus Formation of Type 2N von Willebrand Disease under Both High and Low Shear Conditions2017
- Author(s)
  Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
- Organizer
  International society of thrombosis and haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田　弘史, 野上　恵嗣, 竹中亜利沙, 河村　武志, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Activated FVIII Released From FVIII/VWF Complex Facilitates Thrombus Development Under Flow Condition2017
- Author(s)
  Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
- Organizer
  East Asia hemophilia forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017
- Author(s)
  南博明, 野上恵嗣, 笹井香那, 古川晶子, 武山雅博, 嶋緑倫
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017
- Author(s)
  南　　博明, 野上　恵嗣, 笹井　香那, 古川　晶子, 武山　雅博, 嶋　　緑倫
- Organizer
  第79回　日本血液学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第IX因子微量存在化におけるemicizumabの凝固能改善効果2017
- Author(s)
  荻原　建一, 南　　博明, 野上　恵嗣, 松本　智子, 北沢　剛久, 服部　有宏, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 抗FIXa/FX-bispecific抗体（Emicizumab）のType2N von Willebrand病での血流下血栓形成能の改善効果2017
- Author(s)
  矢追博章、志田泰明、野上恵嗣、北沢剛久、服部有宏、嶋　緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] 血液凝固第VII因子の軌跡と今後の展望2017
- Author(s)
  野上恵嗣
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] Clinical and immunological profiles of Mild/Moderate hemophilia A patients with inhibitor2017
- Author(s)
  Furukawa S, Nogami K, Shima M
- Organizer
  7th East Asia Hemophilia Forum 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] PT・aPTT混合試薬による凝固波形解析を用いた新たな凝固機能評価法の有用性2017
- Author(s)
  吉本知史、松本智子、野上恵嗣、嶋緑倫
- Organizer
  第60回　日本臨床検査医学会近畿支部総会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017
- Author(s)
  古川晶子, 野上恵嗣, 荻原建一, 嶋緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] リン脂質抗体陽性例の凝固波形解析を用いたフィブリン溶解反応における凝固線溶動態の特性2017
- Author(s)
  松本　智子，, 野上　恵嗣, 笹井　香那, 荻原　建一, 矢田　弘史, 竹中亜利沙, 嶋　　緑倫
- Organizer
  第18回　日本検査血液学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017
- Author(s)
  松本　智子, 野上　恵嗣, 笹井　香那, 荻原　建一, 竹中亜利沙, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017
- Author(s)
  古川　晶子, 野上　恵嗣, 荻原　建一, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Mode of Enhancement in the Global Hemostatic Potentials with Concomitant Use of Bypassing Agents and Emicizumab in Hemophilia A Patients with Inhibitor Evaluated by ROTEM2017
- Author(s)
  Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Increasing of ternary complex formation by predominant accumulation of factor (F)X accompanied by increase of FIXa contributes to enhancement of clotting function by APCC in combination with emicizumab.2017
- Author(s)
  Yada K, Nogami K, Matsumoto T, Kitazawa T, Shima M
- Organizer
  59th ASH Annual meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Factor VIIIa mimetic bispecific antibody(Emicizumab) improves thrombus formation of von Willebrand disease under high shear flow conditions2017
- Author(s)
  Shida Y, Nogami K, Yaoi H, Kitazawa T, Shima M
- Organizer
  7th East Asia Hemophilia Forum 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017
- Author(s)
  松本　智子, 野上　恵嗣, 田渕　有香, 添田　哲弘, 新井　信夫, 北沢　剛久, 高岡　秀成, 服部　有宏, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17K10127
[Presentation] Factor VIII A1 Residues 346-349 is a Novel Thrombin-binding Site Responsible for cleavage at Arg372 in the Heavy Chain2017
- Author(s)
  Minami H, Nogami K, Sasai K, Furukawa S, Takeyama M, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Anti FIXa/FX Bispecific Antibody (Emicizumab) Enhances Plasma Procoagulant Activity In Hemophilia B in the Presence of Very Low Level of Factor IX2017
- Author(s)
  Ogiwara K, Minami H, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Factor VIIIa mimetic bispecific antibody (emicizumab) improves thrombus formation of von Willebrand disease under high shear flow condition2017
- Author(s)
  Yasuaki Shida, Hiroaki Yaoi, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
- Organizer
  East Asia hemophilia forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10126
[Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017
- Author(s)
  松本　智子, 野上　恵嗣, 田渕　有香, 添田　哲弘, 新井　信夫, 北沢　剛久, 高岡　秀成, 服部　有宏, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Tenase (Xase) 反応軸に基づく中等症・軽症血友病Ａにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田弘史, 野上恵嗣, 竹中亜利沙, 河村武志, 嶋緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017
- Author(s)
  松本　智子, 野上　恵嗣, 笹井　香那, 荻原　建一, 竹中亜利沙, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017
- Author(s)
  松本智子, 野上恵嗣, 笹井香那, 荻原建一, 竹中亜利沙, 嶋緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田弘史, 野上恵嗣, 竹中亜利沙, 河村武志, 嶋緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016
- Author(s)
  Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  The 58th American Society of Hematology
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] A novel mechanism on thrombin-catalyzed activation of factor VIII molecule during the clot formation2016
- Author(s)
  Keiji Nogami
- Organizer
  第38回日本血栓止血学会学術集会 SPCシンポジウム
- Place of Presentation
  奈良
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K09663
[Presentation] Activated FVIII Released From FVIII/VWF Complex Facilitates Thrombus Development Under Flow Condition2016
- Author(s)
  Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima, Keiji Nogami
- Organizer
  American society of hematology
- Place of Presentation
  San Diego
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016
- Author(s)
  Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  第78回日本血液学会
- Place of Presentation
  パシフィコ横浜（横浜市西区みなとみらい）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] A New Classification of Mild/Moderate Hemophilia Α Based on a Multi-Dimensional FVIII(a) Functions Evaluated By a Plasma-Based Factor Xa Generation2016
- Author(s)
  Yada K, Nogami K, Takenaka A, Kawamura T and Shima M
- Organizer
  58th ASH Annual meeting and Exposition
- Place of Presentation
  Sandiego, CA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Impact of FVIIIa mimicking antibody, emicizumab, on shear dependent thrombus formation2016
- Author(s)
  Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima, Keiji Nogami
- Organizer
  Japanese society of hematology
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] Anti-Factor IXa/FX antibody (ACE910) improves the coagulation function in acquired hemophilia A ex vivo.2015
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Takehisa Kitazawa, Kunihiro Hattori and Midori Shima
- Organizer
  The 57th American Society of Hematology
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 血流下血栓形成能は2N型von Willebrand病の臨床的重症度を反映する2015
- Author(s)
  薮本仁美、矢田弘史、志田泰明、武山雅博、野上恵嗣、細川和也、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] The impact of red blood cells on hemostasis under whole blood flow conditions2015
- Author(s)
  Yaoi H., Shida Y., Nogami K., Minami H., Matsumoto T, Ogiwara K., Hosokawa K.， Shima M
- Organizer
  25th International Society of Thrombosis and Hemostasis
- Place of Presentation
  Toronto, Canada
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] Arg593Cys変異を伴う軽症血友病Aにおける凝固障害はリン脂質との結合親和性低下に関連する2015
- Author(s)
  矢田弘史，野上恵嗣，神谷尚，嶋　緑倫
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  山梨県
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] 血流下血栓形成能は1型及び2型von Willebrand病に対するデスモプレシン投与効果を反映する2015
- Author(s)
  矢田弘史、野上恵嗣、志田泰明、武山雅博、細川和也、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 第VIII因子重鎖A2ドメイン上における第X(a)因子結合部位の同定2015
- Author(s)
  武山雅博、野上恵嗣、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 血流下血栓形成過程における第Ⅷ因子代替バイスペシフィック抗体ACE910の作用機序2015
- Author(s)
  矢追博章、志田泰明、野上恵嗣、南博明、北沢剛久、服部有宏、嶋　緑倫
- Organizer
  第37回血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] A microchip flow-chamber system reflects the clinical phenotype in type 1 von Willebrand disease2015
- Author(s)
  野上恵嗣、矢田弘史、志田泰明、武山雅博、矢追博章、南　博明、古川晶子、嶋　緑倫
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] The usefulness of desmopressin loading test for the diagnosis of severe type 1 von Willebrand disease2015
- Author(s)
  武山雅博, 大仲雅之, 矢田弘史, 志田泰明, 松本智子, 早川正樹, 松本雅則, 野上恵嗣, 嶋　緑倫
- Organizer
  第57回日本小児血液がん学会
- Place of Presentation
  山梨
- Year and Date
  2015-11-29
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] ACE910 improves the coagulation activities in acquired hemophilia A2015
- Author(s)
  武山雅博，野上恵嗣，矢田弘史，松本智子，北沢剛久，服部有宏，嶋　緑倫
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] A novel diagnostic system of acquired coagulation factor inhibitors using comprehensive coagulation assays2015
- Author(s)
  Matsumoto T, Nogami K, Shima M
- Organizer
  XXV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Canada, Toronto
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] Longitudinal profile of FVIII-specific IgG subclass during immune rolerance induction therapy2015
- Author(s)
  Matsumoto T, Nogami K, Shima M
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県、金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] A Novel Plasma-based Factor Xa Generation Assay Defines Interaction Between FVIIIa and Each Component of Xase Complex in Mild Hemophilia A.2015
- Author(s)
  Kamiya N, Yada K, Nogami K, and Shima M
- Organizer
  The International Society on Thrombosis and Haemostasis (ISTH) 2015
- Place of Presentation
  Tronto, Canada
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Enhanced Global Hemostatic Potentials with a Bispecific Antibody to Factors IXa and X (ACE910) in the Whole Blood By Rotation Thromboelastometry (ROTEM).2015
- Author(s)
  Koji Yada, Keiji Nogami, Yasuaki Shida, Masahiro Takeyama, Ryu Kasai, and Midori Shima
- Organizer
  The 57th American Society of Hematology
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] A case of moderate hemophilia A with p.R1800H mutation complicated with juvenile idiopathic arthritis2015
- Author(s)
  Shida Y., Kondo Y., Ishikawa T., Yada K., Takeyama M., Nogami K., Shima M
- Organizer
  25th International Society of Thrombosis and Hemostasis
- Place of Presentation
  Toronto, Canada
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] Seven cases of acquired hemophilia A2015
- Author(s)
  Nozomi Okahashi, Ei Hoshino, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Hiroshi Kimura, Koji Yada, Yasuaki Shida, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 軽症血友病Ｂ患者の急性大動脈解離に対して、遺伝子組換え第IX因子製剤により人工血管置換術の周術期管理を行った１例2015
- Author(s)
  武山雅博、志田泰明、矢田弘史、野上恵嗣、嶋　緑倫
- Organizer
  第1回西日本血友病B研究会
- Place of Presentation
  大阪
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 微量のTFを添加した改変APTTを用いた血友病Aインヒビターのバイパス止血モニタリング法の確立2015
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第16回　日本検査血液学会学術集会
- Place of Presentation
  愛知県、名古屋市
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] 全血流動システムによって示される赤血球のずり速度依存性止血効果2015
- Author(s)
  矢追　博章, 志田　泰明, 野上　恵嗣, 松本　智子, 荻原　建一, 細川　和也, 嶋　緑倫
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] Application of clot waveform analysis to hemostatic monitoring of bypassing therapy2014
- Author(s)
  Keiji Nogami
- Organizer
  60th Annual Scientific and Standardization Committee (SSC)
- Place of Presentation
  Milwaukee, IL, USA
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] The impact of Total-Thrombus Analysis System in the management of VWD with severe anemia2014
- Author(s)
  Shida Y., Nogami K., Minami H., Yada K., Takeyama M., Matsumoto T., Ogiwara K., Shima M.
- Organizer
  日本血液学会
- Place of Presentation
  大阪
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] A novel regulatory mechanism of FVIIa/TF associated with FVIII on the initial phase of coagulation2014
- Author(s)
  野上恵嗣
- Organizer
  第36回血栓止血学会SPCシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2014-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] 包括的な新規凝固線溶能の評価2014
- Author(s)
  松本　智子、野上　恵嗣
- Organizer
  第59回　日本臨床検査医学会近畿支部総会
- Place of Presentation
  天理医療大学（天理市）
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] Distinct localization of coagulation factor VIII, von Willebrand factor and factor VIII-mimetic bispecific antibody contributing to thrombus formation under whole blood flow conditions2014
- Author(s)
  Shida Y., Nogami K., Minami H., Yaoi H., Matsumoto T., Kitazawa T., Hattori K., Shima M
- Organizer
  American Society of Hematology
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-26461593
[Presentation] 新規凝固機能検査による評価；T-TASとThrombin generation testの基本と臨床2013
- Author(s)
  松本　智子、荻原　建一、野上　恵嗣、嶋　緑倫
- Organizer
  第14回　日本検査血液学会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] 後天性凝固因子インヒビターの基礎と病態2013
- Author(s)
  野上恵嗣
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] 凝固波形解析を用いた血液凝固過程における各凝固因子の役割2013
- Author(s)
  松本　智子、野上　恵嗣、宮座　静香、矢田　弘史、荻原　建一、南　博明、古川　晶子、嶋　緑倫。
- Organizer
  第35回　日本血栓止血学会学術集会
- Place of Presentation
  山形国際ホテル（山形市）
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] Usefulness of thrombin generation assay (TGA) for diagnosis of prolonged aPTT with positive LA.2013
- Author(s)
  Matsumoto T, Nogami K, Shima M.
- Organizer
  第75回　日本血液学会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館（札幌市）
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] Thrombin/Plasmin生成同時測定による新規包括的凝固線溶検査2013
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第60回　日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] 自動凝固分析装置（CS-2000i）を用いた新規凝固波形解析の有用性2013
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第14回　日本検査血液学会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] An Optimal Monitoring On Bypassing Therapy for Hemophilia A Patients with Inhibitor Using aPTT-Based Clot Waveform Analysis with the Presence of Minimal TF2012
- Author(s)
  Junka Haku, Kenichi Ogiwara, Tomoko Matsumoto, Koji Yada, Midori Shima, Keiji Nogami
- Organizer
  The 54th annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] A Coagulation Mechanism for the Mild Bleeding Tendency in a Patient with Severe Hemophilia A Possessing an Arg1781His Mutation2012
- Author(s)
  Koji Yada, Keiji Nogami, Kenichi Ogiwara, Hironao Wakabayashi, Philip J. Fay, Midori Shima
- Organizer
  The 54th annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] 活性型プロトロンビン複合体製剤による第VIII因子活性化機構2012
- Author(s)
  矢田弘史、野上恵嗣、荻原建一、松本智子、嶋緑倫
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591558
[Presentation] A novel mechanism of enhancing the haemostatic effect in the combination with recombinant factor VIII and activated prothrombin complex concentrate(APCC) in hemophilia A patients with Inhibitor2011
- Author(s)
  Yada K, Nogami K, et al
- Organizer
  第53回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] A novel missense mutation of factor V(factor V Nara : W1920R) manifested thrombosis and demonstrated a positive result of activated protein C resistance assay2011
- Author(s)
  Shinozawa K, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Coagulation velocity and acceleration correlate with clinical phenotype of patients with acquired factor V inhibitors2011
- Author(s)
  Matsumoto T, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] A role and mechanism of plasmin catalyzed factor VIII activation in blood coagulation and fibrinolysis2011
- Author(s)
  Nogami K
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Procoagulant effect of tranexamic acid with minimal urokinase on ex vivo human hemophilia model under blood flow2011
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] A role and mechanism of plasmin-catalyzed factor VIII activation in blood coagulation and fibrinolysis2011
- Author(s)
  Nogami K
- Organizer
  第23回International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mild clinical phenotype in a severe hemophilia A with Arg1781His substitution associated with increased factor Xa generation2011
- Author(s)
  Yada K, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Evaluation of comprehensive hemostatic function of patients with von Willebrand disease(VWD) under flow using a new microchip flow chamber system2011
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第53回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mild clinical phenotype in a severe hemophilia A with Arg1781Hissubstitution associated with increased factor Xa generation2011
- Author(s)
  Yada K, Nogami K (corresponding author), et al
- Organizer
  第23回International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Perioperative hemostatic management for coarctation of aorta in an early infant with severe haemophilia A2011
- Author(s)
  Furukawa S, Yoshizawa H, Ogiwara K, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Dynamics of plasma factor VIII during the continuous infusion of factor VIII concentrates in twenty patients with hemophilia A2011
- Author(s)
  Nishiya K, Nogami K, et al
- Organizer
  第23回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Effects of anti-FVIII inhibitors on the FVIII neutralization therapy for hemophilia A with inhibitor2011
- Author(s)
  矢田弘史、野上恵嗣(corresponding author), et al
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mechanism of the potent activated protein C resistance of novel factor V mutation with W1920R(FV Nara) relative to R506Q(FV Leiden)2011
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第53回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Procoagulant effect of tranexamic acid with minimal urokinase on ex vivo human hemophilia model under blood flow2011
- Author(s)
  Ogiwara K, Nogami K (corresponding author), et al
- Organizer
  第23回International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Pharmacokinetics of continuous infusion therapy of factor VIII concentrates in hemophilia A patients with inhibitors2011
- Author(s)
  Nishiya K, Tanaka I, Nogami K, et al
- Organizer
  第53回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] A novel mechanism of enhancing the haemostatic effect in the combination with recombinant factor VIII and activated prothrombin complex concentrate (APCC) in hemophilia A patients with Inhibitor2011
- Author(s)
  Yada K, Nogami K (corresponding author), et al
- Organizer
  第53回annual meeting of American Society of Hematology
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Procoagulant activity of antifibrinolytic agents ; A novel hemostatic mechanism of tranexamic acid and epsilon-aminocaproic acid2010
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第52回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Determination of coagulation functions and inhibitory mechanisms in acquired hemophilia A with type 1 and type 2 inhibitors2010
- Author(s)
  Matsumoto T, Nogami K (corresponding author), et al.
- Organizer
  第52回米国血液学会発表
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Tissue factor pathway inhibitor causes unresponsiveness to activated prothrombin complex concentrates for hemophilia A patients with inhibitors2010
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第52回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Determination of coagulation functions and inhibitory mechanisms in acquired hemophilia A with type 1 and type 2 inhibitors2010
- Author(s)
  Matsumoto T, Nogami K, et al
- Organizer
  第52回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Tissue factor pathway inhibitor causes unresponsiveness to activated prothrombin complex concentrates for hemophilia A patients with inhibitor2010
- Author(s)
  Ogiwara K, Nogami K (corresponding author), et al.
- Organizer
  第52回米国血液学会発表
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Dynamics of plasma factor VIII during the continuous infusion of factor VIII concentrates in patients with hemophilia A2010
- Author(s)
  Nishiya K, Tanaka I, Nogami K, et al
- Organizer
  East Asia Haemophilia Forum
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Procoagulant activity of antifibrinolytic agents : A novel hemostatic mechanism of tranexamic and epsilon-aminocaproic acid2010
- Author(s)
  Ogiwara K, Nogami K (corresponding author), et al.
- Organizer
  第52回米国血液学会発表
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mechanisms of factor VIII activation by factor VIIa and its analog NN1731(V158D/E296V/M298Q)2009
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第10回Novo Nordisk Symposium on Hemostasis Management
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Determination for coagulation functions and novel inhibitory mechanisms in acquired hemophilia A with type 2 inhibitors2009
- Author(s)
  Matsumoto T, Nogami K, et al
- Organizer
  第51回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Interactions of factor VIII with tissue factor contributes to the acceleration of factor Xa generation in the initiation phase of blood coagulation2009
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第51回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Procoagulant effect of plasmin dependent on factor V and factor VIII during the blood coagulation process2009
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  第22回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Deep venous thromboembolism in a patient of factor V deficiency2009
- Author(s)
  Nishiya K, Nogami K, et al
- Organizer
  第22回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Effects of anti-FVIII inhibitors on factor VIIa tissue factor-catalyzed activation and inactivation of factor VIII2009
- Author(s)
  Yada K, Nogami K, et al
- Organizer
  第51回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Interactions of factor VIII with tissue factor contributes to the acceleration of factor Xa generation in the initiation phase of blood coagulation2009
- Author(s)
  Ogiwara K, Nogami K(corresponding author), et al.
- Organizer
  第51回米国血液学会発表
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2009-12-08
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Effects of anti-FVIII inhibitors on factor VIIa/tissue factor-catalyzed activation and inactivation of factor VIII2009
- Author(s)
  Yada K, Nogami K(corresponding author), et al.
- Organizer
  第51回米国血液学会発表
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2009-12-08
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Elevation of coagulant activity by plasmin via factor VIII on the blood coagulation2009
- Author(s)
  Ogiwara K, Nogami K(corresponding author), et al.
- Organizer
  第22回国際血栓止血学会
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mechanisms of human neutrophil elastase-catalyzed inactivation of the factor VIII(a)2009
- Author(s)
  Nishiya K, Nogami K, et al
- Organizer
  第51回米国血液学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Mechanisms of human neutrophil elastase-catalyzed inactivation of the factor VIII(a)2009
- Author(s)
  Nishiya K, Nogami K(corresponding author), et al.
- Organizer
  第51回米国血液学会発表
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] Anti-A2 monoclonal antibody enhancing thrombin and factor Xa-catalyzed factor VIII activity2009
- Author(s)
  Takeyama M, Nogami K, et al
- Organizer
  第22回国際血栓止血学会
- Data Source
  KAKENHI-PROJECT-21591370
[Presentation] 活性型第VIII因子軽鎖C2ドメイン上における活性型第IX因子結合部位の同定2008
- Author(s)
  添田哲弘, 野上恵嗣, 他
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都府京都市
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Mechanisms of factor VIII activation by recombinant factor VIIa analog through tissue factor-independent manner2008
- Author(s)
  Ogiwara K, Nogami K, et al
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Tissue factor-dependent activation of factor VIII by factor VIIa in the early phase of bloodcoagulation2008
- Author(s)
  Soeda T, Nogami K, et.al.
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 「血友病の分子病態の進歩と臨床応用の展望」 FVIIa、FVIIIを介する止血メカニズムの新たな展開2008
- Author(s)
  荻原建一、野上恵嗣、他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 活性型第VII因子アナログによる組織因子非依存性の第VIII因子制御機構2008
- Author(s)
  荻原建一, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 6-aminohexanoic acid(6-AHA)の凝固亢進作用2008
- Author(s)
  荻原建一、野上恵嗣、他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Identification of a factor IXa-interactive site within the C2 domain of factor VIIIa and a crucial role of these associations for the process of clot formation2008
- Author(s)
  Soeda T, Nogami K, et.al.
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Identification of a factor IXa-interactive site within the C2 domain of factor VIIIa and a crucial role of these associations for the process of clot formation2008
- Author(s)
  Soeda T, Nogami K, et al
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 6-aminohexanoic acid (6-AHA)の凝固亢進作用2008
- Author(s)
  荻原建一, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Plasminogen/Plasminはlysine-binding site依存性に活性型第V因子と結合する2008
- Author(s)
  西屋克巳, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Lysine-binding site-dependent interaction with plasmin and factor Va responsible for plasmin-catalyzed factor Va inactivation2008
- Author(s)
  Nishiya K, Nogami K, et al
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 活性型第VII因子/組織因子による第VIII因子制御機構2008
- Author(s)
  添田哲弘, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 活性型第IX因子と第VIII因子軽鎖C2ドメイン問特異的阻害ペプチドの抗血栓作用2008
- Author(s)
  添田哲弘, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 血友病A各種病型の第VIII因子活性とトロンビン生成能2008
- Author(s)
  松本智子, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 「血友病の分子病態の進歩と臨床応用の展望」 FVIIa、FVIIIを介する止血メカニズムの新たな展開2008
- Author(s)
  荻原建一, 野上恵嗣, 他
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Tissue factor-dependent activation of factor VIII by factor VIIa in the early phase of blood coagulation2008
- Author(s)
  Soeda T, Nogami K, et al
- Organizer
  50^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして2007
- Author(s)
  西屋克巳、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 第VIII因子軽鎖C2ドメインは活性型第IX因子Glaドメインに結合する2007
- Author(s)
  添田哲弘、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007
- Author(s)
  Takeyama M, Nogami K, et. al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 凝固初期相におけるプラスミンの向凝固作用2007
- Author(s)
  荻原建一、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Role of direct interaction between factor VIII C2 domain and factor IXa Gla domain in facctor Xase complex2007
- Author(s)
  Soeda T, Nogami K, et. al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 第VIII因子軽鎖C2は活性型第IX因子Glaドメインに結合する2007
- Author(s)
  添田哲弘、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 血友病Aインヒビターの免疫生化学的側面2007
- Author(s)
  野上恵嗣
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007
- Author(s)
  Takeyama M, Nogami K, Shima M, et. al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Localization of fastor VIII interastive site within plasmin/plasminogen which is responseible for plasmin-catalyzed activation/inactivation of factor VIII2007
- Author(s)
  Nishiya K, Nogami K, Shima M, et. al
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Localization of factor VIII-interactive site within plasmin/plasminogen which is responsible for plasmin-catalyzed activation/inactivation of factor VIII2007
- Author(s)
  Nishiya K, Nogami K, et. al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Localization of factor VIII-interactive site within plasmin/plasminogen which is responsible for plasmin-catalyzed activation and inactivation of factor VIII2007
- Author(s)
  Nishiya K, Nogami K, et.al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007
- Author(s)
  武山雅博、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして.2007
- Author(s)
  西屋克己、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007
- Author(s)
  武山雅博、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 後天性血友病type2患者のトロンビン生成能低下の作用機序2007
- Author(s)
  松本智子、野上恵嗣、嶋緑倫, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  賢島
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007
- Author(s)
  Takeyama M, Nogami K, et.al.
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 凝固初期相におけるプラスミンの向凝固作用2007
- Author(s)
  荻原建一、野上恵嗣他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島市
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 血友病Aインヒビターの免疫生化学的側面2007
- Author(s)
  野上恵嗣
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島市
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] インヒビター陽性血友病Aに対する補充療法における凝血学的効果の多様性2007
- Author(s)
  矢田弘史、吉田幸一、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] Role of direct interaction between factor C2 and factor IXa Gla domain in factor Xase complex.2007
- Author(s)
  Soeda T, Nogami K, Shima M, et. al
- Organizer
  49^<th> Annual meeting of American Society of Hematology
- Place of Presentation
  Atlanta
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-17591110
[Presentation] 後天性血友病A type2患者のトロンビン生成能低下の作用機序2007
- Author(s)
  松本智子、野上恵嗣, 他
- Organizer
  第30回日本血栓止血学会学術集会
- Place of Presentation
  三重県賢島
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19591264
[Presentation] 血友病Aと抗リン脂質抗体症候群の診断における凝固波形解析の有用性
- Author(s)
  松本　智子、野上　恵嗣、嶋　緑倫
- Organizer
  第15回　日本検査血液学会学術集会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2014-07-20 – 2014-07-21
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] 第V因子変異R506Q（FVLeiden）より強いAPCレジスタンスを示したFV変異W1920R（FVNara）
- Author(s)
  荻原建一，野上恵嗣，篠澤圭子，松本智子，古川晶子，西屋克己，矢田弘史，福武勝幸，嶋緑倫
- Organizer
  第34回日本血栓止血学会
- Place of Presentation
  ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-24591560
[Presentation] Distinction of APC reactivity for acquired coagulation inhibitor can predict the clinical phenotypes
- Author(s)
  Tomoko M, Keiji N, Midori S
- Organizer
  第76回　日本血液学会
- Place of Presentation
  大阪国際会議場（大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461605
[Presentation] Factor VIII A2 domain contains a binding site for factor X
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Midori Shima
- Organizer
  The 56th American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26461592

1. Matsumoto Tomoko (80642678)

# of Collaborated Projects: 4 results

# of Collaborated Products: 47 results
2. TAKEYAMA MASAHIRO (30572010)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
3. Yada Koji (30635785)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
4. SHIMA Midori (30162663)

# of Collaborated Projects: 3 results

# of Collaborated Products: 61 results
5. shida yasuaki (10721566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
6. 荻原建一 (50623500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SUGIMOTO Mitsuhiko (80192128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKURAI Yoshihiko (80347559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 朴永東 (10285364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中宏之 (40281761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石原卓 (00533712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 大西智子 (60645589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 小田朗永 (80547703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 北畠正大 (60457588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 下村大樹 (70723302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IMAMURA Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 細井創

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 松下正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nogami Keiji 野上 恵嗣

NOGAMI Keiji 野上 恵嗣

Research Projects

Research Products

Co-Researchers

Basic research on development of novel therapeutic products for hemophilia A and thrombotic disorders based on the regulation of factor VIII function in the blood coagulationPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

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Identification of mechanism of FVIII-regulated blood coagulation and development on novel therapeutic drugs for hemophilia A and thrombotic diseasePrincipal Investigator

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Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapyPrincipal Investigator

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Nogami Keiji 野上恵嗣

NOGAMI Keiji 野上恵嗣

[Book] 【新生児・小児の血栓症とDIC】血栓症の凝固機能と診断　小児がん関連の凝固障害症の研究から2019