YADA Koji 矢田弘史

Researcher Number	30635785
Affiliation *help	2018 : 奈良県立医科大学, 医学部, その他 2018 : 奈良県立医科大学, 医学部, 助教 2014 – 2017 : 奈良県立医科大学, 医学部, 特任助教 2013 – 2014 : 奈良県立医科大学, 医学部, その他
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator 血友病 / 第VIII因子 / インヒビター / 活性化第VII因子 / 活性化・不活性化 / 第X因子 / 血友病A / 出血性疾患 / 新規治療 / FVIII / 血液凝固 … More Except Principal Investigator … More

中等症・軽症血友病Ａにおける第Ⅷ因子の凝血学的特性に基づく新規治療戦略の開発Principal InvestigatorOngoing
- Principal Investigator
  
  矢田弘史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Studies on molecular pathology of hemophilia A and gain-of-function of FVIIIOngoing
- Principal Investigator
  
  嶋緑倫
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
インヒビター保有軽症血友病Aの凝血学的特性と新規治療戦略に関する基礎的研究Principal InvestigatorOngoing
- Principal Investigator
  
  矢田弘史
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Basic reserch on hemostasis to establish a novel hemostatic therapy for hemophilia A patients with inhibitorsPrincipal Investigator
- Principal Investigator
  
  YADA Koji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University

All 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016
- Author(s)
  Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, MinamiH, Furukawa S, Hosokawa K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume : 14(4) Pages : 667-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] 血友病の治療の進歩2015
- Author(s)
  矢田弘史, 嶋　緑倫
- Journal Title
  
  小児科診療
  
  Volume : 78 Pages : 1780-1788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
- Journal Title
  
  J Thromb Haemost.
  
  Volume : 13 Pages : 1843-1853
- DOI
  10.1111/jth.13118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
[Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume : 13 Pages : 1279-1284
- DOI
  10.1111/jth.12987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] 血栓止血性疾患の遺伝子診断―出血性疾患2015
- Author(s)
  矢田弘史, 野上恵嗣
- Journal Title
  
  日本血栓止血学会誌
  
  Volume : 26 Pages : 513-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] The first case of int1h-related inversion in Japanese haemophilia A patients2014
- Author(s)
  Yada K, Nogami K, Kawamura T, Minami H, Shima M
- Journal Title
  
  Haemophilia
  
  Volume : 20(6)
- DOI
  10.1111/hae.12509
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860878, KAKENHI-PROJECT-26461593
[Journal Article] 血友病に対する治療の進歩(1)-長時間作用型薬剤・抗体医薬の面から-2014
- Author(s)
  矢田弘史，野上恵嗣
- Journal Title
  
  臨床血液
  
  Volume : 55 Pages : 893-898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860878
[Journal Article] The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X.2013
- Author(s)
  Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume : 109(6) Pages : 1007-1015
- DOI
  10.1160/TH12-10-0762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] Different factor VIII neutralizing effects on　anti-factor VIII inhibitor antibodies associated with epitope specificity and von　Willebrand factor.2013
- Author(s)
  Yada K, Nogami K, Shima M.
- Journal Title
  
  British Jornal of Haematology
  
  Volume : 163(1) Pages : 104-111
- DOI
  10.1111/bjh.12473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.2013
- Author(s)
  Yada K, Nogami K, Ogiwara K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume : 11 Issue : 5 Pages : 902-910
- Publisher
  Blackwell Pub.
- DOI
  10.1111/jth.12197
- PMID
  http://www.ncbi.nlm.nih.gov/pubmed/23517528
- Year and Date
  2013-05-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Presentation] 血友病の病態解析の進歩2016
- Author(s)
  矢田　弘史
- Organizer
  第38回日本血栓止血学会学術集会会長シンポジウム
- Place of Presentation
  奈良春日野国際フォーラム
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] A New Classification of Mild/Moderate Hemophilia Α Based on a Multi-Dimensional FVIII(a) Functions Evaluated By a Plasma-Based Factor Xa Generation2016
- Author(s)
  Yada K, Nogami K, Takenaka A, Kawamura T and Shima M
- Organizer
  58th ASH Annual meeting and Exposition
- Place of Presentation
  Sandiego, CA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] A Novel Plasma-based Factor Xa Generation Assay Defines Interaction Between FVIIIa and Each Component of Xase Complex in Mild Hemophilia A.2015
- Author(s)
  Kamiya N, Yada K, Nogami K, and Shima M
- Organizer
  The International Society on Thrombosis and Haemostasis (ISTH) 2015
- Place of Presentation
  Tronto, Canada
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Arg593Cys変異を伴う軽症血友病Aにおける凝固障害はリン脂質との結合親和性低下に関連する2015
- Author(s)
  矢田弘史，野上恵嗣，神谷尚，嶋　緑倫
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  山梨県
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Activated protein C-catalyzed factor Va inactivation is enhanced in the absence of factor VIIIa2014
- Author(s)
  矢田弘史，野上恵嗣，松本智子，北沢剛久，服部有宏，嶋　緑倫
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Activated protein C-catalyzed factor Va inactivation predominantly contributes to the downregulation of coagulation rather than factor VIIIa inactivation.2014
- Author(s)
  Yada K, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
- Organizer
  56th ASH Annual meeting and Exposition
- Place of Presentation
  米国（サンフランシスコ）
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] MC710はインヒビター存在下でも第VIII因子を直接活性化し,rFVIIaに比して相乗的に凝固機能を改善する2014
- Author(s)
  矢田弘史, 野上恵嗣, 嶋緑倫
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Different neutralizing effects of factor VIII concentrates associated with von willebrand factor and the inhibitor epitopes2013
- Author(s)
  Yada K , Nogami K, Ogiwara K and Midori Shima
- Organizer
  XXIV ISTH Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam,Netherlands
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Evaluation of the haemostatic potentials in a mild hemophilia A with a novel factor VIII mutation Thr677Ile2013
- Author(s)
  Yada K , Nogami K, Ogiwara K and Midori Shima
- Organizer
  XXIV ISTH Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam,Netherlands
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Reduced affinity to VWF/PL induced by a novel mutation at P1809L (factor VIII-Tenri) is the cause of mild hemophilia A developing anti-factor VIII inhibitor2013
- Author(s)
  Yada K, Nogami K , Takeyama M , Philip J. Fay and Shima M
- Organizer
  55th ASH Annual meeting and Exposition
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Management of Bypassing Therapy in Hemophilia Patients with Inhibitors Utilizing Global Coagulation Assay.2013
- Author(s)
  Yada K , Shima M
- Organizer
  2013 East Asia Hemophilia Forum
- Place of Presentation
  Seoul,Korea
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] A novel mechanism of development of the inhibitor distinguishing self from non-self associated with Pro1809Leu mutation.2013
- Author(s)
  矢田弘史，野上恵嗣，武山雅博，嶋　緑倫
- Organizer
  第75回　日本血液学会学術集会
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Investigation of risk factors for hemophilic arthropathy in mild/moderate hemophilia A2013
- Author(s)
  矢田弘史, 野上恵嗣, 嶋緑倫
- Organizer
  第55回　日本小児血液がん学会学術集会
- Place of Presentation
  福岡県
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] 凝固一段法による第VIII因子活性(FVIII:C)が臨床的重症度を過小評価した軽症血友病Aの一例2013
- Author(s)
  矢田弘史，野上恵嗣, 荻原建一, 松本智子, 南博明, 古川晶子, 嶋緑倫
- Organizer
  第35回　日本血栓止血学会学術集会
- Place of Presentation
  山形県
- Data Source
  KAKENHI-PROJECT-25860878

1. 野上恵嗣 (50326328)

# of Collaborated Projects : 2results

# of Collaborated Products : 11results
2. 嶋緑倫 (30162663)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
3. 武山雅博 (30572010)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
4. 松本智子 (80642678)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

YADA Koji 矢田 弘史

Research Projects

Research Products

Co-Researchers

中等症・軽症血友病Ａにおける第Ⅷ因子の凝血学的特性に基づく新規治療戦略の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular pathology of hemophilia A and gain-of-function of FVIIIOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インヒビター保有軽症血友病Aの凝血学的特性と新規治療戦略に関する基礎的研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic reserch on hemostasis to establish a novel hemostatic therapy for hemophilia A patients with inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016

Author(s)

Journal Title

Data Source

[Journal Article] 血友病の治療の進歩2015

Author(s)

Journal Title

Data Source

[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血栓止血性疾患の遺伝子診断―出血性疾患2015

Author(s)

Journal Title

Data Source

[Journal Article] The first case of int1h-related inversion in Japanese haemophilia A patients2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血友病に対する治療の進歩(1)-長時間作用型薬剤・抗体医薬の面から-2014

Author(s)

Journal Title

Data Source

[Journal Article] The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different factor VIII neutralizing effects on anti-factor VIII inhibitor antibodies associated with epitope specificity and von Willebrand factor.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.2013

Author(s)

Journal Title

Publisher

DOI

PMID

Year and Date

Language

Data Source

[Presentation] 血友病の病態解析の進歩2016

Author(s)

YADA Koji 矢田弘史

[Journal Article] Different factor VIII neutralizing effects on　anti-factor VIII inhibitor antibodies associated with epitope specificity and von　Willebrand factor.2013