Yada Koji 矢田弘史

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YADA Koji 矢田弘史

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Researcher Number	30635785
Other IDs
Affiliation (Current)	2022: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2021: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 2017 – 2020: 奈良県立医科大学, 医学部, 助教 2014 – 2017: 奈良県立医科大学, 医学部, 特任助教 2013 – 2014: 奈良県立医科大学, 医学部, その他
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator インヒビター / 血友病A / 第VIII因子 / 血友病 / F8遺伝子変異 / 血液凝固 / 新規治療 / 出血性疾患 / FVIII / 活性化・不活性化 … More / 活性化第VII因子 / 第X因子 / 分子異常症 / 凝固機能 … More Except Principal Investigator 血友病 / 血友病A / 第VIII因子 / 第IX因子 / 第X因子 / 高機能型 / 遺伝子治療 / トロンビン / 活性型第IX因子 / 活性型第X因子 / リン脂質 / 内科 / 小児科 / 血液 / 血栓止血 Less

血友病A患者・保因者の第Ⅷ因子遺伝子型に基づく病態解析と新規個別化治療戦略の開発Principal Investigator
- Principal Investigator
  
  矢田弘史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
Development of novel therapeutic strategy based on hemostatic characteristics of FVIII in the patients with moderate/mild hemophilia APrincipal Investigator
- Principal Investigator
  
  Yada Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Studies on molecular pathology of hemophilia A and gain-of-function of FVIII
- Principal Investigator
  
  Midori Shima
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Basic research on establishment of a novel hemostatic treatment based on the hemostatic potential for mild hemophilia A with inhibitorPrincipal Investigator
- Principal Investigator
  
  Yada Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Basic reserch on hemostasis to establish a novel hemostatic therapy for hemophilia A patients with inhibitorsPrincipal Investigator
- Principal Investigator
  
  YADA Koji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University

All 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Emicizumab Improves Ex Vivo Clotting Function in Patients with Mild/Moderate Hemophilia A2020
- Author(s)
  Nakajima Yuto、Nogami Keiji、Yada Koji、Furukawa Shoko、Noguchi-Sasaki Mariko、Hirata Michinori、Shima Midori
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: オンライン Pages: 968-976
- DOI
  10.1055/s-0040-1710315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-18K07798
[Journal Article] Assessment of self‐/parent‐reported quality of life in Japanese children with haemophilia using the Japanese version of KIDSCREEN‐522020
- Author(s)
  Furuichi Yasuko、Nogami Keiji、Yada Koji、Nezu Satoko、Obayashi Kenji、Saeki Keigo、Kurumatani Norio、Nakajima Mitsuru、Kinoshita Seiji、Shima Midori
- Journal Title
  
  Haemophilia
  
  Volume: 26 Pages: 243-250
- DOI
  10.1111/hae.13945
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.2020
- Author(s)
  Yada K, Nogami K
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology.
  
  Volume: 40(5) Pages: 1148-1154
- DOI
  10.1161/atvbaha.120.312919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Global coagulation function assessed by rotational thromboelastometry predicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019
- Author(s)
  Yada K , Nogami K, Ogiwara K, Shida Y, Furukawa S, Yaoi H, Takeyama M, Kasai R,Shima M.
- Journal Title
  
  Int J Hematol.
  
  Volume: 110(4) Pages: 419-430
- DOI
  10.1007/s12185-019-02698-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10126
[Journal Article] Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease. Haemophilia.2019
- Author(s)
  Nakajima Y, Nogami K, Yada K , Ogiwara K, Furukawa S, Shimonishi N, Shima M.
- Journal Title
  
  Haemophilia
  
  Volume: 25(3)
- DOI
  10.1111/hae.13725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Spotlight on emicizumab in the management of hemophilia A:patient selection and special considerations.2019
- Author(s)
  Yada K , Nogami K
- Journal Title
  
  Journal of blood medicine
  
  Volume: 10 Pages: 171-181
- DOI
  10.2147/jbm.s175952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07798
[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor.2018
- Author(s)
  Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
- Journal Title
  
  British Journal of Haematology
  
  Volume: ahead of printing Pages: 528-536
- DOI
  10.1111/bjh.15209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-18K07885
[Journal Article] Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V2018
- Author(s)
  Yada Koji、Nogami Keiji、Shinozawa Keiko、Kitazawa Takehisa、Hattori Kunihiro、Amano Kagehiro、Fukutake Katsuyuki、Shima Midori
- Journal Title
  
  British Journal of Haematology
  
  Volume: 183 Pages: 257-266
- DOI
  10.1111/bjh.15525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04231
[Journal Article] Successful prophylaxis using activated prothrombin complex concentrates (aPCC) in a severe haemophilia A patient with inhibitor previously unresponsive to on-demand daily infusions of aPCC.2017
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Shima M.
- Journal Title
  
  Haemophilia
  
  Volume: 23
- DOI
  10.1111/hae.13310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664
[Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016
- Author(s)
  Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, MinamiH, Furukawa S, Hosokawa K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 14(4) Pages: 667-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
- Journal Title
  
  Journal of Thrombosis Haemostasis
  
  Volume: 13 Pages: 1843-1853
- DOI
  10.1111/jth.13118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
[Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015
- Author(s)
  Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 13 Pages: 1279-1284
- DOI
  10.1111/jth.12987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] 血友病の治療の進歩2015
- Author(s)
  矢田弘史, 嶋　緑倫
- Journal Title
  
  小児科診療
  
  Volume: 78 Pages: 1780-1788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] 血栓止血性疾患の遺伝子診断―出血性疾患2015
- Author(s)
  矢田弘史, 野上恵嗣
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 26 Pages: 513-517
- NAID
  130005102998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09664
[Journal Article] The first case of int1h-related inversion in Japanese haemophilia A patients2014
- Author(s)
  Yada K, Nogami K, Kawamura T, Minami H, Shima M
- Journal Title
  
  Haemophilia
  
  Volume: 20(6)
- DOI
  10.1111/hae.12509
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860878, KAKENHI-PROJECT-26461593
[Journal Article] 血友病に対する治療の進歩(1)-長時間作用型薬剤・抗体医薬の面から-2014
- Author(s)
  矢田弘史，野上恵嗣
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 893-898
- NAID
  130004688002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860878
[Journal Article] Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.2013
- Author(s)
  Yada K, Nogami K, Ogiwara K, Shima M
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 11(5) Pages: 902-910
- DOI
  10.1111/jth.12197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X.2013
- Author(s)
  Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 109(6) Pages: 1007-1015
- DOI
  10.1160/th12-10-0762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Journal Article] Different factor VIII neutralizing effects on　anti-factor VIII inhibitor antibodies associated with epitope specificity and von　Willebrand factor.2013
- Author(s)
  Yada K, Nogami K, Shima M.
- Journal Title
  
  British Jornal of Haematology
  
  Volume: 163(1) Pages: 104-111
- DOI
  10.1111/bjh.12473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
[Presentation] Additive effect on the global clotting function in moderate/mild hemophilia A by addition of emicizumab, evaluated by clot waveform analysis2019
- Author(s)
  Nakajima Y, Nogami K, Yada K, Furukawa S, Noguchi M, Hirata M, Shima M
- Organizer
  International Society on Thrombosis and Hemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] インヒビター保有血友病A患者における活性型第VII因子による凝固改善に必要な第X因子に関する定量的検討2019
- Author(s)
  矢田弘史、野上恵嗣、坪田夏芽、嶋　緑倫
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018
- Author(s)
  Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
- Organizer
  ６０thAmerican Society of Hematology　Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 1.Bドメイン除去(BDD)第VIII 因子(FVIII)においてFVIIa/TF 惹起FVIII 不活化は遷延される2018
- Author(s)
  中島　由翔，矢田弘史，野上恵嗣，嶋緑倫
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] Utility of converted factor VIII activity by thrombin generation assay for evaluation of clotting function among hemophilia A carriers2018
- Author(s)
  Nogami K, Kawamura T, Shima M, Yada K
- Organizer
  World Federation of Hemophilia 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 4.A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018
- Author(s)
  Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
- Organizer
  60th American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07798
[Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田　弘史, 野上　恵嗣, 竹中亜利沙, 河村　武志, 嶋　　緑倫
- Organizer
  第39回　日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Mode of enhancement in the global hemostatic potentials with concomitant use of bypassing agents and emicizumab in hemophilia A patients with inhibitor evaluated by ROTEM.2017
- Author(s)
  Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
- Organizer
  The XXVI Congress of the ISTH and 63rd Annual Scientific and Standardization Committee (SSC) Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Mode of Enhancement in the Global Hemostatic Potentials with Concomitant Use of Bypassing Agents and Emicizumab in Hemophilia A Patients with Inhibitor Evaluated by ROTEM2017
- Author(s)
  Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Tenase (Xase) 反応軸に基づく中等症・軽症血友病Ａにおける異常FVIIIの多元的機能解析2017
- Author(s)
  矢田弘史, 野上恵嗣, 竹中亜利沙, 河村武志, 嶋緑倫
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Increasing of ternary complex formation by predominant accumulation of factor (F)X accompanied by increase of FIXa contributes to enhancement of clotting function by APCC in combination with emicizumab.2017
- Author(s)
  Yada K, Nogami K, Matsumoto T, Kitazawa T, Shima M
- Organizer
  59th ASH Annual meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] A New Classification of Mild/Moderate Hemophilia Α Based on a Multi-Dimensional FVIII(a) Functions Evaluated By a Plasma-Based Factor Xa Generation2016
- Author(s)
  Yada K, Nogami K, Takenaka A, Kawamura T and Shima M
- Organizer
  58th ASH Annual meeting and Exposition
- Place of Presentation
  Sandiego, CA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] 血友病の病態解析の進歩2016
- Author(s)
  矢田　弘史
- Organizer
  第38回日本血栓止血学会学術集会会長シンポジウム
- Place of Presentation
  奈良春日野国際フォーラム
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] A Novel Plasma-based Factor Xa Generation Assay Defines Interaction Between FVIIIa and Each Component of Xase Complex in Mild Hemophilia A.2015
- Author(s)
  Kamiya N, Yada K, Nogami K, and Shima M
- Organizer
  The International Society on Thrombosis and Haemostasis (ISTH) 2015
- Place of Presentation
  Tronto, Canada
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Arg593Cys変異を伴う軽症血友病Aにおける凝固障害はリン脂質との結合親和性低下に関連する2015
- Author(s)
  矢田弘史，野上恵嗣，神谷尚，嶋　緑倫
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  山梨県
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K09664
[Presentation] Activated protein C-catalyzed factor Va inactivation is enhanced in the absence of factor VIIIa2014
- Author(s)
  矢田弘史，野上恵嗣，松本智子，北沢剛久，服部有宏，嶋　緑倫
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-11-02
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Activated protein C-catalyzed factor Va inactivation predominantly contributes to the downregulation of coagulation rather than factor VIIIa inactivation.2014
- Author(s)
  Yada K, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
- Organizer
  56th ASH Annual meeting and Exposition
- Place of Presentation
  米国（サンフランシスコ）
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] MC710はインヒビター存在下でも第VIII因子を直接活性化し,rFVIIaに比して相乗的に凝固機能を改善する2014
- Author(s)
  矢田弘史, 野上恵嗣, 嶋緑倫
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Reduced affinity to VWF/PL induced by a novel mutation at P1809L (factor VIII-Tenri) is the cause of mild hemophilia A developing anti-factor VIII inhibitor2013
- Author(s)
  Yada K, Nogami K , Takeyama M , Philip J. Fay and Shima M
- Organizer
  55th ASH Annual meeting and Exposition
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Different neutralizing effects of factor VIII concentrates associated with von willebrand factor and the inhibitor epitopes2013
- Author(s)
  Yada K , Nogami K, Ogiwara K and Midori Shima
- Organizer
  XXIV ISTH Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam,Netherlands
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] A novel mechanism of development of the inhibitor distinguishing self from non-self associated with Pro1809Leu mutation.2013
- Author(s)
  矢田弘史，野上恵嗣，武山雅博，嶋　緑倫
- Organizer
  第75回　日本血液学会学術集会
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Management of Bypassing Therapy in Hemophilia Patients with Inhibitors Utilizing Global Coagulation Assay.2013
- Author(s)
  Yada K , Shima M
- Organizer
  2013 East Asia Hemophilia Forum
- Place of Presentation
  Seoul,Korea
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Evaluation of the haemostatic potentials in a mild hemophilia A with a novel factor VIII mutation Thr677Ile2013
- Author(s)
  Yada K , Nogami K, Ogiwara K and Midori Shima
- Organizer
  XXIV ISTH Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam,Netherlands
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] Investigation of risk factors for hemophilic arthropathy in mild/moderate hemophilia A2013
- Author(s)
  矢田弘史, 野上恵嗣, 嶋緑倫
- Organizer
  第55回　日本小児血液がん学会学術集会
- Place of Presentation
  福岡県
- Data Source
  KAKENHI-PROJECT-25860878
[Presentation] 凝固一段法による第VIII因子活性(FVIII:C)が臨床的重症度を過小評価した軽症血友病Aの一例2013
- Author(s)
  矢田弘史，野上恵嗣, 荻原建一, 松本智子, 南博明, 古川晶子, 嶋緑倫
- Organizer
  第35回　日本血栓止血学会学術集会
- Place of Presentation
  山形県
- Data Source
  KAKENHI-PROJECT-25860878

1. 野上恵嗣 (50326328)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
2. Midori Shima (30162663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. 武山雅博 (30572010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 松本智子 (80642678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 志田泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yada Koji 矢田 弘史

YADA Koji 矢田 弘史

Research Projects

Research Products

Co-Researchers

血友病A患者・保因者の第Ⅷ因子遺伝子型に基づく病態解析と新規個別化治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategy based on hemostatic characteristics of FVIII in the patients with moderate/mild hemophilia APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular pathology of hemophilia A and gain-of-function of FVIII

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research on establishment of a novel hemostatic treatment based on the hemostatic potential for mild hemophilia A with inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic reserch on hemostasis to establish a novel hemostatic therapy for hemophilia A patients with inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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[Journal Article] Emicizumab Improves Ex Vivo Clotting Function in Patients with Mild/Moderate Hemophilia A2020

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[Journal Article] Assessment of self‐/parent‐reported quality of life in Japanese children with haemophilia using the Japanese version of KIDSCREEN‐522020

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[Journal Article] Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.2020

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[Journal Article] Global coagulation function assessed by rotational thromboelastometry predicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019

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[Journal Article] Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease. Haemophilia.2019

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[Journal Article] Spotlight on emicizumab in the management of hemophilia A:patient selection and special considerations.2019

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[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor.2018

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[Journal Article] Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V2018

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[Journal Article] Successful prophylaxis using activated prothrombin complex concentrates (aPCC) in a severe haemophilia A patient with inhibitor previously unresponsive to on-demand daily infusions of aPCC.2017

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Yada Koji 矢田弘史

YADA Koji 矢田弘史

[Journal Article] Different factor VIII neutralizing effects on　anti-factor VIII inhibitor antibodies associated with epitope specificity and von　Willebrand factor.2013