Takahashi Keita 高橋圭太

… Alternative Names

TAKAHASHI Keita 高橋圭太

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Researcher Number	50634929
Other IDs
Affiliation (Current)	2025: 岐阜薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 岐阜薬科大学, 薬学部, 講師 2020 – 2023: 岐阜薬科大学, 薬学部, 講師 2016 – 2019: 岐阜薬科大学, 薬学部, 助教 2012 – 2013: 産業医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / General pharmacology Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator Citrobacter rodentium / 粘膜ワクチン / アジュバント / 乳酸菌 / 腸管出血性大腸菌 / DNAワクチン / 細菌様粒子 / 経口ワクチン / ワクチン / 腸管病原性大腸菌 … More / Citrobacter rodetnium / bacterium-like particles / 乳酸菌ベクター / 細胞性免疫 / 分泌型IgA / 粘膜免疫 / パイエル板 / 粘膜ワクチン系 / M細胞 / ファージディスプレイ / 核内受容体 / カテコールアミン / 植物性エストロゲン / 細胞膜受容体 / エストロゲン … More Except Principal Investigator 免疫学 / Rho GTPase / RhoGEF / アクチン重合 / III型分泌機構 / シトロバクター・ローデンティウム / 腸管出血性大腸菌 Less

感染最初期段階をターゲットとした腸管病原性大腸菌の新規粘膜ワクチン開発Principal Investigator
- Principal Investigator
  
  高橋圭太
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gifu Pharmaceutical University
乳酸菌をキャリアとする粘膜ワクチン系開発に関する研究Principal Investigator
- Principal Investigator
  
  高橋圭太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gifu Pharmaceutical University
Research on oral vaccine systems using lactic acid bacteria as vectorsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Keita
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gifu Pharmaceutical University
Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant development
- Principal Investigator
  
  Sugiyama Tsuyoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gihu University of Medical Science
  Gifu Pharmaceutical University
Development of oral vaccine platform using lactic acid bacteriaPrincipal Investigator
- Principal Investigator
  
  Takahashi Keita
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Gifu Pharmaceutical University
Analysis of a novel membrane estrogen receptor signaling and identification of its genePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Keita
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Evaluation of the protective effect of the intranasal vaccines adjuvanted with bacterium-like particles against intestinal infection2024
- Author(s)
  Ayato Tsujii, Keita Takahashi, Haruki Harada, Sarana Kawashima, Hina Oikawa, Hiroki Fukushima, Yuta Hayakawa, Juri Koizumi, Naoki Inoue and Tetsuo Koshizuka
- Journal Title
  
  Vaccine
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07071
[Journal Article] The adjuvant effect of bacterium-like particles depends on the route of administration.2023
- Author(s)
  Sudo H, Tokunoh N, Tsujii A, Kawashima S, Hayakawa Y, Fukushima H, Takahashi K, Koshizuka T, Inoue N.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1082273-1082273
- DOI
  10.3389/fimmu.2023.1082273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07071
[Journal Article] Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with Citrobacter rodentium2021
- Author(s)
 Takahashi Keita、Sugiyama Tsuyoshi、Tokunoh Nagisa、Tsurumi Shun、Koshizuka Tetsuo、Inoue Naoki
- Journal Title
 
 ImmunoHorizons
 
 Volume: 5 Issue: 10 Pages: 870-883
- DOI
 10.4049/immunohorizons.2100087
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K16649
[Journal Article] Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria.2020
- Author(s)
  Keita Takahashi, Nozomi Orito, Daiki Yanagisawa, Ayumu Yano, Yusuke Mori, Naoki Inoue
- Journal Title
  
  Vaccine
  
  Volume: 38 Issue: 17 Pages: 3330-3338
- DOI
  10.1016/j.vaccine.2020.02.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16649
[Journal Article] Current Issues Regarding the Application of Recombinant Lactic Acid Bacteria to Mucosal Vaccine Carriers2019
- Author(s)
  Keita Takahashi, Nozomi Orito, Nagisa Tokunoh, Naoki Inoue
- Journal Title
  
  Applied microbiology and biotechnology
  
  Volume: 103 Issue: 15 Pages: 5947-5955
- DOI
  10.1007/s00253-019-09912-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16649
[Journal Article] Protective effects of oral immunization with formalin-inactivated whole-cell Citrobacter rodentium on Citrobacter rodentium infection in mice.2019
- Author(s)
  Keita Takahashia, Yuki Hanamura, Nagisa Tokunoh, Kohei Kassai, Masaru Matsunishi, Shiori Watanabe, Tsuyoshi Sugiyama, Naoki Inoue
- Journal Title
  
  Journal of Microbiological Methods
  
  Volume: 159 Pages: 62-68
- DOI
  10.1016/j.mimet.2019.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19127
[Journal Article] Peyer’s Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo2018
- Author(s)
 Ayumu Yano, Keita Takahashi, Yusuke Mori, Shiori Watanabe, Yuki Hanamura, Tsuyoshi Sugiyama, Naoki Inoue
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 41 Issue: 2 Pages: 190-197
- DOI
 10.1248/bpb.b17-00657
- NAID
 130006329249
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-16K19127
[Journal Article] M cell-targeting strategy enhances systemic and mucosal immune responses induced by oral administration of nuclease-producing L. lactis.2018
- Author(s)
  Keita Takahashi, Ayumu Yano, Shiori Watanabe, Philippe Langella, Luis G. Bermúdez-Humarán, Naoki Inoue
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: 102 Issue: 24 Pages: 10703-10711
- DOI
  10.1007/s00253-018-9427-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] Effect of the administration route of the adjuvanticity of bacterium-like particles (BLPs) derived from Lactococcus lactis2023
- Author(s)
  Sudo H, Tokunoh N, Tsujii A, Kawashima S, Hayakawa Y, Fukushima H, Takahashi K, Koshizuka T, Inoue N.
- Organizer
  Convolution of Informatics and Biomedical Sciences on Glocal Alliances
- Data Source
  KAKENHI-PROJECT-22K07071
[Presentation] Bacterium-like particles as a promising adjuvant for nasal vaccines targeting intestinal infections2023
- Author(s)
  Haruka Sudo, Ayato Tsujii, Hina Oikawa, Nagisa Tokunoh, Sarana Kawashima, Yuta Hayakawa, Hiroki Fukushima, Keita Takahashi, Naoki Inoue, Tetsuo Koshizuka
- Organizer
  17th Vaccine Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07071
[Presentation] The effect of antigen binding and administration route of BLP on its immunogenicity2022
- Author(s)
  Haruka Sudo, Ayato Tsujii, Tetsuo Koshizuka, Naoki Inoue, Keita Takahashi
- Organizer
  第95回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Intimate adhesion of Citrobacter rodentium is the cue to initiate anti-pathogen immune2022
- Author(s)
  Keita Takahashi,† Tsuyoshi Sugiyama, Nagisa Tokunoh, Shun Tsurumi, Tetsuo Koshizuka, Naoki Inoue
- Organizer
  第95回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Oral immunization with antigen/adjuvant co-producing Lactococcus lactis2020
- Author(s)
  Keita Takahashi, Nagisa Tokunoh, Daiki Yanagisawa, Naoki Inoue
- Organizer
  第93回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Eosinophils are the main cellular target for DNA delivery from orally administrated L. lactis2020
- Author(s)
  Daiki Yanagisawa, Nozomi Orito, Keita Takahashi, Nagisa Tokunoh, Naoki Inoue
- Organizer
  第93回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Evaluation of the mucosal vaccine system using bacterium-like particles prepared from L. lactis2020
- Author(s)
  Nagisa Tokunoh, Keita Takahashi, Nozomi Orito, Daiki Yanagisawa, Naoki Inoue
- Organizer
  第93回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Development of the oral vaccine system using lactic acid bacteria2019
- Author(s)
  Keita Takahashi, Naoki Inoue
- Organizer
  第31回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Identification of cellular targets for DNA delivery from recombinant L. lactis strains in vivo2019
- Author(s)
  Keita Takahashi, Nozomi Orito, Daiki Yanagisawa, Naoki Inoue
- Organizer
  27th European Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] M cell-targeting enhances immune responses induced by oral immunization with Ag-producing L. lactis2019
- Author(s)
  Keita Takahashi*, Nozomi Orito, Nagisa Tokunoh, Naoki Inoue
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] LAP increases the DNA delivery efficiency of Internalin A-expressing invasive Lactococcus lactis2019
- Author(s)
  Nozomi Orito, Keita Takahashi, Daiki Yanagisawa, Naoki Inoue
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] M cell-targeting enhances immune responses induced by oral immunization with Ag-producing L. lactis2019
- Author(s)
  Keita Takahashi, Nozomi Orito, Nagisa Tokunoh, Naoki Inoue
- Organizer
  第92回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Listeria adhesion protein increases the DNA delivery efficiency of Internalin A-expressing invasive Lactococcus lactis2019
- Author(s)
  Nozomi Orito, Keita Takahashi, Naoki Inoue
- Organizer
  第92回日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16649
[Presentation] Development of a Rapid and Convenient Method for Quantification of Citrobacter rodentium2018
- Author(s)
  Yuki Hanamura, Keita Takahashi, Masaru Matsunishi, Kohei Kassai, Shiori Watanabe, Yusuke Mori, Nozomi Orito, Tsuyoshi Sugiyama, Naoki Inoue
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] KIAA0599 augments TRIF- and Myd88-dependent TLR signaling2018
- Author(s)
  Tsuyoshi Sugiyama, Kanna Nakao, Ryo Hayami, Takuya Hasegawa, Keita Takahashi, Naoki Inoue, Takahiro Nagase, Hiroshi Ueda
- Organizer
  Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] M cell-targeting enhances immune responses induced by nuclease-producing Lactococcus lactis2018
- Author(s)
  高橋圭太、矢野歩、渡辺詩織、森祐介、杉山剛志、井上直樹
- Organizer
  第91回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] Development of a rapid and convenient method for quantification of Citrobacter rodentium2018
- Author(s)
  花村有希、高橋圭太、松西優、葛西康平、渡辺詩織、森祐介、折戸希、杉山剛志、井上直樹
- Organizer
  第91回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] M cell-targeting enhances immune responses induced by nuclease-producing Lactococcus lactis2018
- Author(s)
  Keita Takahashi, Ayumu Yano, Shiori Watanabe, Yusuke Mori Tsuyoshi Sugiyama, Naoki Inoue
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] 組換え乳酸菌を用いた免疫誘導2017
- Author(s)
  井上直樹、渡辺詩織、花村有希、矢野歩、松西優、森祐介、杉山剛志、高橋圭太、Philippe Langella, Luis G. Bermúdez-Humarán, Tarik Issad
- Organizer
  第46回　東海乳酸菌研究会
- Place of Presentation
  愛知県
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] Rhoグアニンヌクレオチド交換因子PLEKHG3によるTRIF依存的シグナル増強作用2017
- Author(s)
  中尾莞奈、早水良、秋元奈央、長谷川拓也、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  第54 回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 乳酸菌を用いた経口ワクチン系の改良2017
- Author(s)
  森祐介、花村有希、折戸希、井上直樹、高橋圭太
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会２０１7
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] A/E病変に伴うアクチンの重合が制御する宿主遺伝子発現2017
- Author(s)
  安田祐里花、鶴見駿、早水良、惠西丈彦、高橋圭太、井上直樹、杉山剛志
- Organizer
  第21 回腸管出血性大腸菌感染症研究会参加
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 乳酸菌を用いたDNAワクチン送達法の検討2016
- Author(s)
  矢野歩、高橋圭太、松西優、渡邊詩織、森祐介、花村有希、所俊志、Langella Phillippe、Bermudez-Humaran Luis、杉山剛志、井上直樹
- Organizer
  第7回　機能性健康食品（蜂産品）研究会
- Place of Presentation
  岐阜県
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] 腸管上皮細胞におけるRho GTPase活性化のToll様受容体シグナルへの影響2016
- Author(s)
  矢端文彦、中尾莞奈、早水良、田中秀幸、児玉雄大、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] モデル抗原を発現する組換え乳酸菌を用いた免疫条件の検討と免疫誘導の評価2016
- Author(s)
  渡邊詩織、矢野歩、森祐介、花村有希、高橋圭太、杉山剛志、井上直樹、Philippe Langella, Luis G. Bermúdez-Humarán, Tarik Issad
- Organizer
  第20回　日本ワクチン学会
- Place of Presentation
  東京都
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K19127
[Presentation] ARHGEF15 augments TRIF-dependent pathway of TLR signaling via enhancing the phosphorylation of IRF-32016
- Author(s)
  Sugiyama T, Hasegawa T, Takahashi K, Inoue N., Nagase T., Ueda H.
- Organizer
  14th Biennial Meeting of International Endotoxin and Innate Immunity Society
- Place of Presentation
  ドイツ・ハンブルグ
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241

1. Sugiyama Tsuyoshi (70268001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 上田浩 (50253779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Takahashi Keita 高橋 圭太

TAKAHASHI Keita 高橋 圭太

Research Projects

Research Products

Co-Researchers

感染最初期段階をターゲットとした腸管病原性大腸菌の新規粘膜ワクチン開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳酸菌をキャリアとする粘膜ワクチン系開発に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on oral vaccine systems using lactic acid bacteria as vectorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of oral vaccine platform using lactic acid bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel membrane estrogen receptor signaling and identification of its genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluation of the protective effect of the intranasal vaccines adjuvanted with bacterium-like particles against intestinal infection2024

Author(s)

Journal Title

Data Source

[Journal Article] The adjuvant effect of bacterium-like particles depends on the route of administration.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with <i>Citrobacter rodentium</i>2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current Issues Regarding the Application of Recombinant Lactic Acid Bacteria to Mucosal Vaccine Carriers2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effects of oral immunization with formalin-inactivated whole-cell Citrobacter rodentium on Citrobacter rodentium infection in mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peyer’s Patches as a Portal for DNA Delivery by <i>Lactococcus lactis</i> <i>in Vivo</i>2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] M cell-targeting strategy enhances systemic and mucosal immune responses induced by oral administration of nuclease-producing L. lactis.2018

Author(s)

Takahashi Keita 高橋圭太

TAKAHASHI Keita 高橋圭太