Hayashi Takuji 林拓自

Researcher Number	50747079
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 助教 2022: 大阪大学, 大学院医学系研究科, 招へい教員 2021: 大阪大学, 医学系研究科, 招へい教員 2018 – 2019: 大阪大学, 医学系研究科, 招へい教員 2017: 大阪大学, 医学系研究科, 医員 2016 – 2017: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Urology
Keywords	Principal Investigator モデルマウス / 炎症 / 高脂肪食 / 免疫細胞 / 前立腺癌 / 肥満 / 腸内細菌叢 / 炎症反応 / 癌 / 抗PD-1抗体 / HVJ-E … More Except Principal Investigator … More 尿中バイオマーカー / エクソソーム / 前立腺癌 Less

癌微小環境にも着目した尿路上皮癌への新規併用治療の最適化と逐次療法の探索Principal Investigator
- Principal Investigator
  
  林拓自
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Osaka
Elucidation of high-fat diet-inbduced inflammation and application to treatment for prostate cancerPrincipal Investigator
- Principal Investigator
  
  Hayashi Takuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
The mechanism of immune cells associated with prostate cancer progressionPrincipal Investigator
- Principal Investigator
  
  Hayashi Takuji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Osaka University
The analysis of prostate cancer exosome and the development of new urinary biomarker
- Principal Investigator
  
  Fujita Kazutoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Osaka University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] High-fat diet promotes prostate cancer growth through histamine signaling.2022
- Author(s)
  Matsushita M, Fujita K, Hatano K, Hayashi T, Kayama H, Motooka D, Hase H, Yamamoto A, Uemura T, Yamamichi G, Tomiyama E, Koh Y, Kato T, Kawashima A, Uemura M, Nojima S, Imamura R, Mubeen A, Netto GJ, Tsujikawa K, Nakamura S, Takeda K, Morii E, Nonomura N.
- Journal Title
  
  Int J Cancer
  
  Volume: in press Issue: 4 Pages: 623-636
- DOI
  10.1002/ijc.34028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09689, KAKENHI-PROJECT-21K09421, KAKENHI-PROJECT-23K24471, KAKENHI-PROJECT-18K16693
[Journal Article] Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling.2021
- Author(s)
  Matsushita M, Fujita K, Hayashi T, Kayama H, Motooka D, Hase H, Jingushi K, Yamamichi G, Yumiba S, Tomiyama E, Koh Y, Hayashi Y, Nakano K, Wang C, Ishizuya Y, Kato T, Hatano K, Kawashima A, Ujike T, Uemura M, Imamura R, Rodriguez Pena MDC, Gordetsky JB, Netto GJ, Tsujikawa K, Nakamura S, Takeda K, Nonomura N.
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 15 Pages: 4014-4026
- DOI
  10.1158/0008-5472.can-20-4090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09689, KAKENHI-PROJECT-21K09421, KAKENHI-PROJECT-18K16693
[Journal Article] Obesity, Inflammation, and Prostate Cancer.2019
- Author(s)
  Fujita K, Hayashi T, Matsushita M, Uemura M, Nonomura N.
- Journal Title
  
  J Clin Med.
  
  Volume: 8 Issue: 2 Pages: 201-25
- DOI
  10.3390/jcm8020201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09689, KAKENHI-PROJECT-18K16693
[Journal Article] Metformin inhibits prostate cancer growth induced by high-fat diet in Pten-deficient model mice2018
- Author(s)
  Takuji Hayashi, Kazutoshi Fujita, Makoto Matsushita, Yujiro Hayashi, Motohide Uemura, Norio Nonomura
- Journal Title
  
  International Journal of Urology
  
  Volume: 26 Issue: 2 Pages: 307-309
- DOI
  10.1111/iju.13847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16693, KAKENHI-PROJECT-19K09689
[Journal Article] High-fat diet-induced inflammation accelerates prostate cancer growth via IL6 signaling2018
- Author(s)
  Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, et al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24 Issue: 17 Pages: 4309-4318
- DOI
  10.1158/1078-0432.ccr-18-0106
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16693, KAKENHI-PROJECT-16K11003
[Journal Article] Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens.2017
- Author(s)
  Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Kentaro Jingushi, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Eiichi Morii, Norio Nonomura
- Journal Title
  
  The Prostate
  
  Volume: 77 Pages: 1383-1388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20137
[Journal Article] Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.2016
- Author(s)
  Takuji Hayashi, Kazutoshi Fujita, Go Tanigawa, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Tetsuya Takao, Seiji Yamaguchi, Norio Nonomura
- Journal Title
  
  Oncotarget
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 前立腺癌モデルマウスにおいて、高脂肪食による局所での炎症・免疫反応はIL6シグナルを介して癌の進展を促進する2018
- Author(s)
  林　拓自、藤田和利、野島　聡、林裕次郎、神宮司健太郎、加藤大悟、河嶋厚成、氏家　剛、永原　啓、植村元秀、森井英一、辻川和丈、野々村祝夫
- Organizer
  第106回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-18K16693
[Presentation] 高脂肪食は局所のIL6シグナルを介した炎症反応によって前立腺癌の進展を促進する2018
- Author(s)
  林　拓自、藤田和利、野島　聡、林裕次郎、中野剛佑、石津谷祐、王　総、山本致之、木内利郎、松崎恭介、神宮司健太郎、加藤大悟、河嶋厚成、氏家　剛、永原　啓、植村元秀、森井英一、辻川和丈、野々村祝夫
- Organizer
  第27回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 前立腺癌モデルマウスにおいて、高脂肪食は癌の進展と前立腺組織内免疫細胞の腫瘍促進性変化を起こす2017
- Author(s)
  林　拓自、藤田和利、石津谷　祐、王　聡、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家　剛、永原　啓、植村元秀、野島　聡、森井英一、野々村祝夫
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 前立腺癌モデルマウスにおいて高脂肪食による腫瘍進展は免疫反応と関連する2017
- Author(s)
  林　拓自、藤田和利、野島　聡、木内利郎、松崎恭介、神宮司健太郎、河嶋厚成、氏家　剛、永原　啓、植村元秀、辻川和丈、森井英一、野々村祝夫
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 高脂肪食摂取は前立腺癌の進展を促進し、局所の免疫細胞を変化させる2017
- Author(s)
  林　拓自、藤田和利、石津谷　祐、王　総、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家　剛、永原　啓、植村元秀、野々村祝夫
- Organizer
  第26回泌尿器科分子・細胞研究会
- Place of Presentation
  大分
- Year and Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 高グリソンスコアの前立腺癌患者の末梢血中単球分画は上昇している2017
- Author(s)
  林　拓自、藤田和利、谷川　剛、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家　剛、永原　啓、植村元秀、高尾徹也、山口誓司、野々村祝夫
- Organizer
  第55回日本癌治療学会総会
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] High fat diet-induced inflammation accelerates tumor progression in mice model for prostate cancer2017
- Author(s)
  Takuji Hayashi, Kazutoshi Fujita, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Norio Nonomura
- Organizer
  AUA 2017 Annual Meeting
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 遺伝子改変前立腺癌発症モデルマウスの樹立とその自然史2016
- Author(s)
  林　拓自、藤田和利、山本致之、木内利郎、松崎恭介、川村憲彦、中田　渡、吉田栄宏、河嶋厚成、氏家　剛、永原　啓、植村元秀、野々村祝夫
- Organizer
  第104回日本泌尿器科学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-16K20137
[Presentation] 遺伝子改変前立腺癌モデルマウスにおける局所での免疫細胞の検討2016
- Author(s)
  林　拓自、藤田和利、石津谷　祐、王　総、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家　剛、永原　啓、植村元秀、野々村祝夫
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K20137

1. Fujita Kazutoshi (50636181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KUME Hideaki (50322714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUZAKI Kyousuke (90747081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野々村祝夫 (30263263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 植村元秀 (40631015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松下慎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Hayashi Takuji 林 拓自

Research Projects

Research Products

Co-Researchers

癌微小環境にも着目した尿路上皮癌への新規併用治療の最適化と逐次療法の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of high-fat diet-inbduced inflammation and application to treatment for prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of immune cells associated with prostate cancer progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of prostate cancer exosome and the development of new urinary biomarker

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High-fat diet promotes prostate cancer growth through histamine signaling.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Obesity, Inflammation, and Prostate Cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin inhibits prostate cancer growth induced by high-fat diet in Pten-deficient model mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-fat diet-induced inflammation accelerates prostate cancer growth via IL6 signaling2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens.2017

Author(s)

Journal Title

Data Source

[Journal Article] Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.2016

Author(s)

Journal Title

Data Source

[Presentation] 前立腺癌モデルマウスにおいて、高脂肪食による局所での炎症・免疫反応はIL6シグナルを介して癌の進展を促進する2018

Author(s)

Organizer

Data Source

[Presentation] 高脂肪食は局所のIL6シグナルを介した炎症反応によって前立腺癌の進展を促進する2018

Author(s)

Organizer

Data Source

[Presentation] 前立腺癌モデルマウスにおいて、高脂肪食は癌の進展と前立腺組織内免疫細胞の腫瘍促進性変化を起こす2017

Author(s)

Organizer

Data Source

[Presentation] 前立腺癌モデルマウスにおいて高脂肪食による腫瘍進展は免疫反応と関連する2017

Author(s)

Organizer

Data Source

[Presentation] 高脂肪食摂取は前立腺癌の進展を促進し、局所の免疫細胞を変化させる2017

Author(s)

Organizer

Hayashi Takuji 林拓自