Okada Keita 岡田慶太

Researcher Number	50759173
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 医学部附属病院, 講師 2015 – 2021: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 58080:Gerontological nursing and community health nursing-related / Orthopaedic surgery
Keywords	Principal Investigator 軟骨 / HIF-1α / 変形性関節症 / 軟骨内骨化 / cartilage / SFZ / Notch signal / 変形性膝関節症 / Prg4 / Notchシグナル … More / 軟骨表層 / SFZ細胞 / NFκB / HIF-1alpha / 整形外科学 / 低酸素 / HIF-１α / 脊椎 / 関節軟骨 / 変形性脊椎症 / 低酸素誘導因子 … More Except Principal Investigator 変形性関節症 / 発育性股関節形成不全 / 新生児訪問 / 関節軟骨 / 整形外科学 / シングルセル解析 / 破骨細胞 / 軟骨 / スクリーニング / フレキシブルプローブ / アセスメント / フィジカルアセスメント / 教育プログラム / エコースクリーニング / HIF-2α / HIF-1α / 酸素濃度勾配 / 変形性膝関節症 / 骨軟骨代謝学 / 滑膜組織 / 関節恒常性 / 線維芽細胞 / マクロファージ / 滑膜 / マクロファージ分化 / 異物排除と寛容 / マウス腹腔内異物投与モデル / カルシウム振動 / 異物反応 / 異物巨細胞 / 次世代シーケンサー / 動物モデル / 足関節軟骨 / 膝関節軟骨 / 軟骨代謝 / 膝関節 / 足関節 Less

Development of a nursing educational program and implementation for ultrasound hip screening during newborn home visits
- Principal Investigator
  
  吉岡京子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  The University of Tokyo
Development of a real-time assessment method for developmental dysplasia of the hip using a flexible probe
- Principal Investigator
  
  吉岡京子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  The University of Tokyo
骨膜プロジェニター群を中心とした骨格成長制御メカニズムの解析Principal Investigator
- Principal Investigator
  
  岡田慶太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of joint stem cell maintenance by Notch signalingPrincipal Investigator
- Principal Investigator
  
  Okada Keita
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
次世代シングルセル解析技術を用いた破骨細胞分化の制御機構の解明
- Principal Investigator
  
  小俣康徳
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Elucidation of articular joint homeostasis regulated by the cellular network in the synovium
- Principal Investigator
  
  Tanaka Sakae
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Molecular mechanisms underlying homeostasis of artiuclar joint by oxygen and two HIFs
- Principal Investigator
  
  Mori Daisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Differentiation mechanism of foreign body giant cells
- Principal Investigator
  
  Matsubara Takehiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Molecular mechanisms underlying anti-inflammatory and cartilage protective roles of HIF-1alphaPrincipal Investigator
- Principal Investigator
  
  Okada Keita
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Investigation of cartilage homeostasis and molecular biology by comparison of ankle and knee joint
- Principal Investigator
  
  Matsumoto Takumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Function of HIFs in the joints and spinePrincipal Investigator
- Principal Investigator
  
  Okada Keita
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] Plasmalemmal interface for calcium signaling in osteoclast differentiation2022
- Author(s)
  Okada Hiroyuki、Tanaka Sakae
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 74 Pages: 55-61
- DOI
  10.1016/j.ceb.2022.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703, KAKENHI-PROJECT-22K10212
[Journal Article] Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption2020
- Author(s)
  Okada Hiroyuki、Okabe Koji、Tanaka Sakae
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 180-180
- DOI
  10.3390/ijms22010180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-19H03822, KAKENHI-PROJECT-18K09017
[Journal Article] Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw2020
- Author(s)
  Soma T, Iwasaki R, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Ito E, Okada H, Watanabe H, Miyamoto K, Matsumoto M, Nakamura M, Asoda S, Kawana H, Nakagawa T, Miyamoto T
- Journal Title
  
  J Bone Miner Metab
  
  Volume: - Issue: 3 Pages: 372-384
- DOI
  10.1007/s00774-020-01174-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09580, KAKENHI-PROJECT-19K10365, KAKENHI-PROJECT-20K09461, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-19K09655
[Journal Article] The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells2020
- Author(s)
  Kushioka Junichi、Kaito Takashi、Chijimatsu Ryota、Okada Rintaro、Ishiguro Hiroyuki、Bal Zeynep、Kodama Joe、Yano Fumiko、Saito Taku、Chung Ung-il、Tanaka Sakae、Yoshikawa Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 14190-14190
- DOI
  10.1038/s41598-020-71193-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-20K09428, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-20K09473, KAKENHI-PROJECT-20K18053, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K22677, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-18K09019
[Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020
- Author(s)
  Okada Keita、Mori Daisuke、Makii Yuma、Nakamoto Hideki、Murahashi Yasutaka、Yano Fumiko、Chang Song Ho、Taniguchi Yuki、Kobayashi Hiroshi、Semba Hiroaki、Takeda Norihiko、Piao Wen、Hanaoka Kenjiro、Nagano Tetsuo、Tanaka Sakae、Saito Taku
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5425-5425
- DOI
  10.1038/s41598-020-62463-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-19K22677, KAKENHI-PUBLICLY-18H04609, KAKENHI-PUBLICLY-19H05414, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-17K10996, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997, KAKENHI-PROJECT-20K09405
[Journal Article] CTLA4-Ig directly inhibits osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages.2019
- Author(s)
  Okada H, Kajiya H, Omata Y, Matsumoto T, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Nakamura S, Koyama T, Sudo S, Shin M, Okamoto F, Watanabe H, Tachibana N, Hirose J, Saito T, Takai T, Matsumoto M, Nakamura M, Okabe K, Miyamoto T, Tanaka S.
- Journal Title
  
  J Bone Miner Res
  
  Volume: 34 Issue: 9 Pages: 1744-1752
- DOI
  10.1002/jbmr.3754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-19K09580, KAKENHI-PROJECT-19K10301, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-19H03822
[Presentation] Surgical management of permanent patella dislocation by Stanisavljevic procedure.2021
- Author(s)
  Keita Okada, Hiroshi Inui, Shuji Taketomi, Nobuhiko Haga, Sakae Tanaka
- Organizer
  Asia Pacific Paediatric Orthopedic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09452
[Presentation] O脚の診断2021
- Author(s)
  岡田慶太、田中栄
- Organizer
  日本小児整形外科学会
- Data Source
  KAKENHI-PROJECT-20K09452
[Presentation] 当院（都市部大学病院）における乳幼児股関節二次検診の動向2021
- Author(s)
  岡田慶太　滝川一晴　伊藤順一　田中弘志　芳賀信彦　田中栄
- Organizer
  日本整形外科学会
- Data Source
  KAKENHI-PROJECT-20K09452
[Presentation] 破骨細胞分化初期の共刺激-カルシウムオシレーション-NFATc1 軸 ~特に共刺激周囲の補因子について2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、岡部幸司、宮本健史、田中栄
- Organizer
  第93回日本生化学会大会　シンポジウム「Calcineurin/NFATシグナルのダイバーシティ」
- Invited
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] Dectin-2, a Fc receptor gamma-harboring receptor, regulates foreign body reaction by interfering with intracellular calcium oscillation.2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、岡部幸司、宮本健史、田中栄
- Organizer
  ASBMR 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] CTLA4-Ig (Abatacept) Directly Inhibited Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations via Fc receptor gamma2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、松本卓巳、首藤俊一、進正史、岡本富士雄、廣瀬旬、岡部幸司、宮本健史、田中栄
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] Dectin-2はFcRγと会合し、カルシウム振動に干渉し異物反応を制御する2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、岡部幸司、宮本健史、田中栄
- Organizer
  第38回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] 単球由来巨細胞の分化誘導スイッチ : カルシウムオシレーション2019
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、斎藤琢、岡部幸司、宮本健史、田中栄
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] Calcium oscillations in early osteoclast differentiation2019
- Author(s)
  岡田寛之、鍛治屋浩浩、小俣康徳、斎藤琢、岡部幸司、宮本健史、田中栄
- Organizer
  第20回運動器科学研究会
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] ITAM受容体は破骨細胞分化初期のCalcium oscillationを巧みに調節する2019
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、進正史、岡本富士雄、斎藤琢、岡部幸司、宮本健史、田中栄
- Organizer
  第37回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] CTLA4-Ig directly inhibited osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages2019
- Author(s)
  Hiroyuki Okada, Hiroshi Kajiya, Yasunori Omata, Takumi Matsumoto, Shunichi Sudo, Masashi Shin, Fujio Okamoto, Jun Hirose, Koji Okabe, Takeshi Miyamoto, Sakae Tanaka
- Organizer
  ASBMR 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] CTLA4-Igによる破骨細胞形成直接抑制メカニズム2018
- Author(s)
  岡田寛之、鍛冶屋浩、松本卓巳、廣瀬旬、岡部幸司、宮本健史、田中栄
- Organizer
  20th Asia Pacific League of Associations for Rheumatology Congress、第4回日本骨免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] Fine tuning of calcium oscillations by ITAM receptors regulates RANKL-induced osteoclast differentiation.2018
- Author(s)
  岡田寛之、鍛冶屋浩、松本卓巳、廣瀬旬、岡部幸司、宮本健史、田中栄
- Organizer
  ASBMR 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09017
[Presentation] 低酸素誘導因子HIFの軟骨分化制御2016
- Author(s)
  岡田慶太
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  福岡県
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H06170
[Presentation] 低酸素誘導因子HIFによる軟骨分化制御2016
- Author(s)
  岡田慶太
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H06170
[Presentation] 低酸素誘導因子HIFによる変形性関節症の制御について2015
- Author(s)
  岡田慶太
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  富山県
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15H06170

1. 齋藤琢 (30456107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. Matsumoto Takumi (70436468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. Mori Daisuke (60835354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 矢野文子 (80529040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 吉岡京子 (00708951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 富井直輝 (00803602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Matsubara Takehiro (40361498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Tanaka Sakae (50282661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小林寛 (20407951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小俣康徳 (40570734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 宮本健史 (70383768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. 千々松良太 (60803210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 乾洋 (60583119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 塩見美抄 (10362766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 細谷紀子 (60334182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中川桂一 (00737926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松本博成 (50966108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 本田千可子 (80845751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 寺島明日香 (30596937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡田寛之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 佐藤結子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okada Keita 岡田 慶太

Research Projects

Research Products

Co-Researchers

Development of a nursing educational program and implementation for ultrasound hip screening during newborn home visits

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a real-time assessment method for developmental dysplasia of the hip using a flexible probe

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨膜プロジェニター群を中心とした骨格成長制御メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of joint stem cell maintenance by Notch signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

次世代シングルセル解析技術を用いた破骨細胞分化の制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of articular joint homeostasis regulated by the cellular network in the synovium

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms underlying homeostasis of artiuclar joint by oxygen and two HIFs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation mechanism of foreign body giant cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms underlying anti-inflammatory and cartilage protective roles of HIF-1alphaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of cartilage homeostasis and molecular biology by comparison of ankle and knee joint

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of HIFs in the joints and spinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Plasmalemmal interface for calcium signaling in osteoclast differentiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption2020

Author(s)

Journal Title

DOI

Data Source

Okada Keita 岡田慶太

[Presentation] 当院（都市部大学病院）における乳幼児股関節二次検診の動向2021