OKADA HIKARI 岡田光

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Okada Hikari 岡田光

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Researcher Number	50788916
Other IDs
Affiliation (Current)	2025: 金沢大学, 医薬保健学総合研究科, 協力研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 金沢大学, 医薬保健学総合研究科, 特任准教授 2023: 金沢大学, その他の研究科, 准教授 2019 – 2021: 金沢大学, 医薬保健学総合研究科, 特任助教 2017 – 2018: 金沢大学, 医学系, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 53020:Cardiology-related / Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 免疫応答 / 免疫療法 / 肝細胞癌 / 再発 / 肝線維化 / 発癌 / ICI阻害剤 / 腫瘍免疫 / 腫瘍成長 / Jagged1 … More / Notch1 / PKM2 / PKM1 / Notch / NCID / PKM / 肝発がん / 線維化 / オートファージー / CEBPα / Atg16L1 / 慢性炎症 / オートファジー / ペレチノイン … More Except Principal Investigator 線維化 / 臓器線維化 / 心臓リモデリング / 心筋梗塞 / 遺伝子治療 / アデノ随伴ウイルス / Nrf2 / 生活習慣病 / 肥満 / 肝発がん / 肝線維化 / 新規血管内皮細胞マーカー / セマフォリン / 心不全 / 空間情報解析 / 心筋梗塞後リモデリング / Semaphorin6A / 共焦点顕微鏡 / バイオテクノロジー / ウイルス / 核酸 / 蛋白質 / 肝血管内皮細胞 / 肝再生 / Sema6A / 類洞内皮細胞 / 肝微小環境 / リンパ管新生 / Semaphorin 6A / 虚血性心疾患 / 慢性炎症 Less

肝線維化進行に伴う肝血管内皮の機能不全の原因解明Principal Investigator
- Principal Investigator
  
  岡田光
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Building a research platform to predict ICI response or non-response in HCCPrincipal Investigator
- Principal Investigator
  
  岡田光
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
肝血管内皮細胞を動脈化させるスイッチ因子の機能解析
- Principal Investigator
  
  Nishikawa Masashi
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
感染症の標的となる細胞内因子に対するバイオ医薬の創出・送達技術の開発
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Keio University
新規線維化抑制因子の心臓リモデリング抑制機序の解明：空間情報解析という観点から
- Principal Investigator
  
  大辻浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kanazawa University
レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立
- Principal Investigator
  
  澤本一樹
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Asahikawa Medical College
肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立
- Principal Investigator
  
  本多政夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kanazawa University
Elucidation of HCC immune exhaustion system and establishment of treatment methodsPrincipal Investigator
- Principal Investigator
  
  Okada Hikari
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Elucidation of the mechanisms by which novel vascular endothelial cell markers are involved in liver fibrosis and hepatocarcinogenesis
- Principal Investigator
  
  Nishikawa Masashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Kanazawa Medical Center
The assessment of novel antifibrotic factor Semaphorin6A for cardiac remodeling after myocardial infarction.
- Principal Investigator
  
  OOTSUJI Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kanazawa University
Functional analysis of new therapeutic target factors for tumorigenesis and recurrence with liver fibrosisPrincipal Investigator
- Principal Investigator
  
  Okada Hikari
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Analyzes the mechanism of liver tumorigenesis and recurrence through chronic inflammation.Principal Investigator
- Principal Investigator
  
  Okada Hikari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction?associated steatohepatitis2024
- Author(s)
  Lyu Junyan、Okada Hikari、Sunagozaka Hajime、Kawaguchi Kazunori、Shimakami Tetsuro、Nio Kouki、Murai Kazuhisa、Shirasaki Takayoshi、Yoshida Mika、Arai Kuniaki、Yamashita Tatsuya、Tanaka Takuji、Harada Kenichi、Takamura Toshinari、Kaneko Shuichi、Yamashita Taro、Honda Masao
- Journal Title
  
  Hepatology Communications
  
  Volume: 8 Issue: 5
- DOI
  10.1097/hc9.0000000000000425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-21H04823
[Journal Article] Functional involvement of endothelial lipase in hepatitis B virus infection2023
- Author(s)
  Shirasaki Takayoshi、Murai Kazuhisa、Ishida Atsuya、Kuroki Kazuyuki、Kawaguchi Kazunori、Wang Ying、Ito Satoru、Matsushima Kouji、Yanagawa Hiroshi、Yamashita Taro、Kaneko Shuichi、Honda Masao
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 9
- DOI
  10.1097/hc9.0000000000000206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-21H04823
[Journal Article] Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus2023
- Author(s)
  Nishikawa Masashi、Okada Hikari、Kawaguchi Kazunori、Shimakami Tetsuro、Nio Kouki、Arai Kuniaki、Yamashita Tatsuya、Sasaki Motoko、Kaneko Shuichi、Yamashita Taro、Honda Masao
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 16 Issue: 2 Pages: 263-286
- DOI
  10.1016/j.jcmgh.2023.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06957, KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-21K07905, KAKENHI-PROJECT-21H04823
[Journal Article] FOXM1 Is a Novel Molecular Target of AFP-Positive Hepatocellular Carcinoma Abrogated by Proteasome Inhibition2022
- Author(s)
  Li Ru、Okada Hikari、Yamashita Taro、Nio Kouki、Chen Han、Li Yingyi、Shimakami Tetsuro、Takatori Hajime、Arai Kuniaki、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8305-8305
- DOI
  10.3390/ijms23158305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21H02900
[Journal Article] BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma2022
- Author(s)
  Chen Han、Nio Kouki、Tang Hong、Yamashita Taro、Okada Hikari、Li Yingyi、Doan Phuong Thi Bich、Li Ru、Lv Junyan、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1475-1475
- DOI
  10.3390/ijms23031475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07966, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21H02900
[Journal Article] BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma2021
- Author(s)
  Chen Han、Nio Kouki、Yamashita Taro、Okada Hikari、Li Ru、Suda Tsuyoshi、Li Yingyi、Doan Phuong Thi Bich、Seki Akihiro et.al
- Journal Title
  
  Molecular Oncology
  
  Volume: not available Issue: 8 Pages: 2203-2218
- DOI
  10.1002/1878-0261.12963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17017, KAKENHI-PROJECT-18K15807, KAKENHI-PROJECT-19K23983, KAKENHI-PROJECT-18K07966, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-20K16984
[Journal Article] Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma.2021
- Author(s)
  Suda T, Yamashita T, Sunagozaka H, Okada H, Nio K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 23 Issue: 5 Pages: 1-17
- DOI
  10.3390/ijms23052801
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02900, KAKENHI-PROJECT-21H04823
[Journal Article] Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis2021
- Author(s)
  Iida Noriho、Mizukoshi Eishiro、Yamashita Tatsuya、Yutani Masahiro、Seishima Jun、Wang Ziyu、Arai Kuniaki、Okada Hikari、Yamashita Taro、Sakai Yoshio、Masuo Yusuke、Agustina Rina、Kato Yukio、Fujinaga Yukako、Oshima Masanobu、Honda Masao、Lebreton Fran?ois、Gilmore Michael S.、Kaneko Shuichi
- Journal Title
  
  Nature Cancer
  
  Volume: 2 Issue: 10 Pages: 1039-1054
- DOI
  10.1038/s43018-021-00251-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-21K06688
[Journal Article] Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice2021
- Author(s)
  Shirasaki Takayoshi、Murai Kazuhisa、Honda Masao、Okada Hikari、Innami Yuika、Yamada Atsumu、Shimakami Tetsuro、Kawaguchi Kazunori、Yamashita Taro、Sakai Yoshio、Kaneko Shuichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 13021-13021
- DOI
  10.1038/s41598-021-92128-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04823
[Journal Article] Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma2020
- Author(s)
  Hashiba Tomomi、Yamashita Taro、et al
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 20 Issue: 2 Pages: 30039-4
- DOI
  10.1016/j.jcmgh.2020.02.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18K19538, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-20K08280, KAKENHI-PROJECT-19K17485
[Journal Article] Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.2020
- Author(s)
  T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, T Yamashita, Y Sakai, M Honda, K Harada, S Kaneko.
- Journal Title
  
  J Gastroenterol
  
  Volume: - Issue: 7 Pages: 701-711
- DOI
  10.1007/s00535-020-01679-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-19K17455, KAKENHI-PROJECT-19K17485
[Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.2019
- Author(s)
  Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
- Journal Title
  
  Cell Host Microbe
  
  Volume: 10;25(4) Issue: 4 Pages: 588-601
- DOI
  10.1016/j.chom.2019.02.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-19K17427, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09413
[Journal Article] Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation2019
- Author(s)
  Wang Zijing、Kawaguchi Kazunori、Honda Masao、Hashimoto Shinichi、Shirasaki Takayoshi、Okada Hikari、Orita Noriaki、Shimakami Tetsuro、Yamashita Taro、Sakai Yoshio、Mizukoshi Eishiro、Murakami Seishi、Kaneko Shuichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1621-1621
- DOI
  10.1038/s41598-018-38139-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17H01540
[Journal Article] Characteristics of impaired dendritic cell function in patients with hepatitis B virus infection.2019
- Author(s)
  Yonejima A, Mizukoshi E, Tamai T, Nakagawa H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Okada H, Yamashita T, Sakai Y, Honda M, Kaneko S.
- Journal Title
  
  Hepatology
  
  Volume: 10.1002/hep Issue: 1 Pages: 30637-30637
- DOI
  10.1002/hep.30637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15934
[Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid2018
- Author(s)
  Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 19 Pages: 4969-4974
- DOI
  10.1073/pnas.1802279115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-16K19378, KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K09353, KAKENHI-PROJECT-17K15933
[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.2018
- Author(s)
  1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 19(2) Issue: 2 Pages: 108-108
- DOI
  10.3390/ijms19020108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication.2018
- Author(s)
  Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 13143-13143
- DOI
  10.1038/s41598-018-31421-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16978-16978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90.2017
- Author(s)
  5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
- Journal Title
  
  Scientific Reports.
  
  Volume: 12;7(1) Issue: 1 Pages: 11292-11292
- DOI
  10.1038/s41598-017-11848-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-15K08992
[Journal Article] Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma.2017
- Author(s)
  4.Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S.
- Journal Title
  
  Cancer Cell International
  
  Volume: 17 Pages: 94-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15933
[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet2017
- Author(s)
  Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 25 Pages: 39978-39993
- DOI
  10.18632/oncotarget.18116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
[Journal Article] Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.2017
- Author(s)
  Takamura M, Kurokawa K, Ootsuji H, Inoue O, Okada H, Nomura A, Kaneko S, Usui S.
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 21 Issue: 2
- DOI
  10.1161/jaha.116.004560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15K09135
[Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study.2017
- Author(s)
  Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
- Journal Title
  
  BMC Cancer
  
  Volume: 17 Issue: 1 Pages: 870-870
- DOI
  10.1186/s12885-017-3889-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809
[Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017
- Author(s)
  6.Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S.
- Journal Title
  
  Anticancer Research
  
  Volume: vol. 37 no. 7 Pages: 3397-3403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15933
[Patent] 肝細胞癌株、およびそれを用いた肝細胞癌発症動物モデル2017
- Inventor(s)
  金子周一、本多政夫、山下太郎、岡田光、村居和寿、院南結香
- Industrial Property Rights Holder
  金子周一、本多政夫、山下太郎、岡田光、村居和寿、院南結香
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15933
[Patent] 抗がん剤及び新規医薬のスクリーニング方法2017
- Inventor(s)
  山下太郎、金子周一、本多政夫、清木元治、岡田光
- Industrial Property Rights Holder
  山下太郎、金子周一、本多政夫、清木元治、岡田光
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15933
[Presentation] 肝線維化を抑制するリード抗体のmRNAディスプレイ法による創出2023
- Author(s)
  永渕泰平，加藤里花子，藤原慶，岡田光，本多政夫，土居信英
- Organizer
  第2回日本抗体学会
- Data Source
  KAKENHI-PROJECT-21H04823
[Presentation] 肝線維化を抑制するリード抗体のmRNAディスプレイ法による創出2023
- Author(s)
  永渕泰平，加藤里花子，藤原慶，岡田光，本多政夫，土居信英
- Organizer
  第2回日本抗体学会（鹿児島）
- Data Source
  KAKENHI-PROJECT-23H00554
[Presentation] C型肝炎ウイルス排除後の肝発癌と肝癌進展に寄与する機能未知膜貫通蛋白の同定2023
- Author(s)
  西川昌志、岡田光、本多政夫
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07905
[Presentation] Stem cell/Immune exhausted subclass マウス肝がんの特性解析2023
- Author(s)
  岡田光、山下太郎
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07890
[Presentation] Semaphorin6Aを介した肝類洞内皮と星細胞のクロストークによる肝線維化抑制機序2022
- Author(s)
  岡田光，本多政夫，金子周一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H04823
[Presentation] 肝類洞内皮細胞によるHBV感染肝細胞のAkt-TORC1経路を介したウイルス複製への影響2022
- Author(s)
  下出哲弘，川口和紀，本多政夫，岡田光，村井和寿，李影奕，丹尾幸樹、島上哲朗，荒井邦明，酒井佳夫，山下竜也，水腰英四郎，金子周一，黒木和之，山下太郎
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H04823
[Presentation] Semaphorin 6A を介した肝類洞内皮と星細胞のクロストークによる肝線維化抑制機序2021
- Author(s)
  岡田　光, 本多政夫, 金子周一
- Organizer
  第44回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-21H04823
[Presentation] Stem cell/Immune exhausted subclassマウス肝がんの特性解析2020
- Author(s)
  岡田光・山下太郎・金子周一
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-19K17485
[Presentation] Stem cell/Immune exhausted subclassマウス肝がんの特性解析2020
- Author(s)
  岡田光・山下太郎・金子周一
- Organizer
  第23回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-19K17485
[Presentation] Levocarnitine improves liver histology and the development of hepatocellular carcinoma in the atherogenic high-fat diet NASH-HCC mouse model2018
- Author(s)
  Hikari Okada, Masao Honda, Hajime Sunakozaka, Shuichi Kaneko
- Organizer
  アメリカ肝臓学会(AASLD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933
[Presentation] 1.Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mice are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M2017
- Author(s)
  岡田光、本多政夫、Jean S Campbell、酒井佳夫、山下太郎、川口和則、田中卓二、金子周一
- Organizer
  アメリカ肝臓学会（AASLD）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933

1. OOTSUJI Hiroshi (70581651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Nishikawa Masashi (90794511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 土居信英 (50327673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 本多政夫 (00272980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. 堀本勝久 (40238803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山下太郎 (90377432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 津川仁 (30468483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 澤本一樹 (80608696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 永島田まゆみ (30645510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. MASAKI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 酒井佳夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 関晃裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 山下竜也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高村雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 佐々木素子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 李影奕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKADA HIKARI 岡田 光

Okada Hikari 岡田 光

Research Projects

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Co-Researchers

肝線維化進行に伴う肝血管内皮の機能不全の原因解明Principal Investigator

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Building a research platform to predict ICI response or non-response in HCCPrincipal Investigator

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肝血管内皮細胞を動脈化させるスイッチ因子の機能解析

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感染症の標的となる細胞内因子に対するバイオ医薬の創出・送達技術の開発

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新規線維化抑制因子の心臓リモデリング抑制機序の解明：空間情報解析という観点から

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レドックス調節因子活性制御に基づく新たな肥満症予防および治療法の確立

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肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立

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Elucidation of HCC immune exhaustion system and establishment of treatment methodsPrincipal Investigator

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Elucidation of the mechanisms by which novel vascular endothelial cell markers are involved in liver fibrosis and hepatocarcinogenesis

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The assessment of novel antifibrotic factor Semaphorin6A for cardiac remodeling after myocardial infarction.

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Functional analysis of new therapeutic target factors for tumorigenesis and recurrence with liver fibrosisPrincipal Investigator

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Analyzes the mechanism of liver tumorigenesis and recurrence through chronic inflammation.Principal Investigator

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[Journal Article] Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction?associated steatohepatitis2024

Author(s)

Journal Title

OKADA HIKARI 岡田光

Okada Hikari 岡田光