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Asai(Takano) Chika  浅居 智圭 (高野 智圭)

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TAKANO Chika  高野 智圭

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Researcher Number 50845310
Other IDs
Affiliation (Current) 2026: 日本大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2020 – 2026: 日本大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords
Principal Investigator
ヒト羊膜上皮細胞 / 先天性代謝異常症 / TNIK / TCF/LEF / 多能性と分化 / Wnt経路 / 胎盤 / 細胞治療 / 先天代謝異常症 / SB-431542 … More / TGF-β / TGF-β経路 / 上皮間葉転換 / 多能性幹細胞 / 羊膜上皮細胞 … More
Except Principal Investigator
ライブイメージング / 垂直感染 / 異常妊娠 / 妊娠維持 / 女性生殖器 / 常在微生物叢 / 小分子化合物ライブラリ / 機能ゲノミクススクリーニング / ヒト羊膜上皮細胞 / 細胞間ミトコンドリア移送 / 遺伝子改変ブタ / 細胞移植 / 幹細胞 / 羊膜上皮細胞 Less
  • Research Projects

    (6 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (16 People)
  •  ヒト羊膜上皮細胞におけるライソゾーム特性解析Principal Investigator

    • Principal Investigator
      浅居 智圭 (高野 智圭)
    • Project Period (FY)
      2026 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nihon University
  •  Elucidation of the Mechanisms Underlying Intercellular Horizontal Mitochondrial Transfer

    • Principal Investigator
      三木 敏生
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nihon University
  •  Total microbiota of human female reproductive tract

    • Principal Investigator
      早川 智
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nihon University
  •  In Vivo Dynamics and Functional Evaluation of Intraportal Transplantation of Porcine Amniotic Epithelial Stem Cells

    • Principal Investigator
      MIKI Toshio
    • Project Period (FY)
      2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nihon University
  •  Elucidation of switching mechanism in the Wnt pathway of human amniotic epithelial cellsPrincipal Investigator

    • Principal Investigator
      高野 智圭
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nihon University
  •  Cell Therapy Development for Congenital Metabolic Diseases Using Human Amniotic Epithelial CellsPrincipal Investigator

    • Principal Investigator
      TAKANO Chika
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nihon University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation Patent

  • [Journal Article] Labeling of mitochondria for detection of intercellular mitochondrial transfer2025

    • Author(s)
      Taiko Isamu、Takano Chika、Hayashida Shingo、Kanemaru Kazunori、Miki Toshio
    • Journal Title

      Methods in Cell Biology

      Volume: 194 Pages: 1-17

    • DOI

      10.1016/bs.mcb.2024.05.001

    • ISBN
      9780323992190
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24398, KAKENHI-PROJECT-22K06868
  • [Journal Article] Amniotic epithelial Cell microvesicles uptake inhibits PBMCs and Jurkat cells activation by?inducing mitochondria-dependent apoptosis2025

    • Author(s)
      Cervero-Varona Adrian、Prencipe Giuseppe、Peserico Alessia、Canciello Angelo、House Andrew H.、Santos Helder A.、Perugini Monia、Sulcanese Ludovica、Takano Chika、Miki Toshio、Iannetta Annamaria、Russo Valentina、Mattioli Mauro、Barboni Barbara
    • Journal Title

      iScience

      Volume: 28 Issue: 2 Pages: 111830-111830

    • DOI

      10.1016/j.isci.2025.111830

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24398, KAKENHI-PROJECT-23K15421
  • [Journal Article] Letter to the Editors: Concerning "Hyperleucinosis during infections in maple syrup urine disease post-liver transplantation" by Guilder et al2024

    • Author(s)
      Chika Takano, Erika Ogawa, Natsuko Arai-Ichinoi, Mika Ishige
    • Journal Title

      Molecular Genetics and Metabolism Reports

      Volume: 38 Pages: 101047-101047

    • DOI

      10.1016/j.ymgmr.2023.101047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Journal Article] Insulin resistance in mitochondrial diabetes2023

    • Author(s)
      Chika Takano, Erika Ogawa and Satoshi Hayakawa
    • Journal Title

      Biomolecules

      Volume: 13(1) Issue: 1 Pages: 126-126

    • DOI

      10.3390/biom13010126

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Journal Article] Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells2022

    • Author(s)
      Takano Chika、Horie Masafumi、Taiko Isamu、Trinh Quang Duy、Kanemaru Kazunori、Komine-Aizawa Shihoko、Hayakawa Satoshi、Miki Toshio
    • Journal Title

      Stem Cell Reviews and Reports

      Volume: 18 Issue: 8 Pages: 3083-3091

    • DOI

      10.1007/s12015-022-10420-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K08829, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
  • [Journal Article] Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria2022

    • Author(s)
      Taiko Isamu、Takano Chika、Nomoto Masayuki、Hayashida Shingo、Kanemaru Kazunori、Miki Toshio
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19841-19841

    • DOI

      10.1038/s41598-022-24297-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06868, KAKENHI-PROJECT-22K19574, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-20K17522, KAKENHI-PROJECT-23K24398
  • [Patent] 羊膜由来幹細胞の維持培地、維持培地用サプリメント及び維持培養方法2020

    • Inventor(s)
      三木敏生、高野智圭
    • Industrial Property Rights Holder
      三木敏生、高野智圭
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] Establishment of a noninvasive cell tracking system for visualizing the fate of human amniotic epithelial cells in immunocompetent mice2024

    • Author(s)
      Chika Takano, Ayumi Mizuno-Yamazaki, Millei Kaga, Isamu Taiko, Kazunori Kanemaru, Toshio Miki
    • Organizer
      The Transplantation Society 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Therapeutic Potential of Human Amniotic Epithelial Cells in Lysosomal Storage Diseases2024

    • Author(s)
      Chika Takano, Erika Ogawa, Mika Ishige, Isamu Taiko, Toshio Miki
    • Organizer
      第65回日本先天代謝異常学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Prospects of human amniotic epithelial cell transplantation to treat lysosomal storage diseases2024

    • Author(s)
      Chika Takano, Erika Ogawa, Mika Ishige, Toshio Miki
    • Organizer
      第65回日本先天代謝異常学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Establishment of a noninvasive cell tracking system for visualizing the fate of human amniotic epithelial cells in immunocompetent mice2024

    • Author(s)
      Chika Takano, Millei Kaga, Isamu Taiko, Kazunori Kanemaru, Toshio Miki
    • Organizer
      TTS2024
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Gene Expression Profiling of Human Amniotic Epithelial Cells: Expanding Treatment Horizons for Inherited Metabolic Disorders2024

    • Author(s)
      Chika Takano, Naoto Kuki, Yutaka Furuta, Erika Ogawa, Mika Ishige, Toshio Miki
    • Organizer
      45th Annual meeting of the Society for Inherited Metabolic Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] シングルセルRNA-seqを用いたヒト羊膜上皮細胞の系統学的多様性の解明2024

    • Author(s)
      高野 智圭、Dahlia Eldeeb 、堀江 真史 、太向 勇 、三木 敏生
    • Organizer
      第23回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] 経門脈移植におけるヒト羊膜上皮細胞の生体内動態追跡の検討2024

    • Author(s)
      山﨑歩実, 高野智圭, 加賀三鈴, 太向 勇, 金丸和典, 三木敏生
    • Organizer
      第24回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] ヒト羊膜上皮細胞の分離・培養における臨床用試薬の検討2024

    • Author(s)
      加賀 三鈴 、高野 智圭、太向 勇、三木 敏生
    • Organizer
      第23回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] ヒト羊膜上皮細胞移植により治療可能と考えられる先天性代謝異常症の探索2024

    • Author(s)
      高野 智圭、九鬼 直人、加賀 三鈴 、三木 敏生
    • Organizer
      第23回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] ヒト羊膜上皮細胞を用いたⅡ型肺胞上皮細胞への分化誘導2024

    • Author(s)
      野本 正幸、太向 勇 、加賀 三鈴 、高野 智圭 、金丸 和典、三木 敏生
    • Organizer
      第23回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] ヒト羊膜上皮細胞の臨床応用に向けての試薬検討2024

    • Author(s)
      加賀 三鈴, 高野 智圭, 太向 勇, 西山 宏幸, 中山 智祥, 佐藤 英明, 三木 敏生
    • Organizer
      第22回日本組織移植学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Adding Phe-free amino acid or low Phe peptide to Phe-free formula for treatment of PKU children2024

    • Author(s)
      Erika Ogawa, Chika Takano, Naoki Okamura, Ichiro Morioka, Mika Ishige
    • Organizer
      第65回日本先天代謝異常学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Gene Expression Profiling of Human Amniotic Epithelial Cells: Expanding Treatment Horizons for Inherited Metabolic Disorders2024

    • Author(s)
      Chika Takano, Naoto Kuki, Yutaka Furuta, Erika Ogawa, Mika Ishige, Toshio Miki
    • Organizer
      Society for Inherited Metabolic Disorders
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] ライソゾーム病に対するヒト羊膜上皮細胞を用いた治療開発の可能性2024

    • Author(s)
      高野智圭, 太向 勇, 三木敏生
    • Organizer
      第24回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Impact of diet therapy on gut microbiome composition and immunological status in patients with phenylketonuria2024

    • Author(s)
      Natsuki Ohmi, Chika Takano, Noriko M. Tsuji, Erika Ogawa, Shihoko Komine-Aizawa, Satoshi Hayakawa, Ichiro Morioka, Mika Ishige
    • Organizer
      3rd International Symposium of Clinical Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] フェニルケトン尿症における食事療法が幼児期の腸内細菌叢と免疫学的背景に及ぼす影響2024

    • Author(s)
      高野智圭, 大海なつき, 小川えりか, 石毛美夏, 辻 典子, 早川 智, 相澤志保子
    • Organizer
      第27回臨床腸内微生物学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Direct differentiation of human amniotic epithelial cells to type II alveolar epithelial cells2023

    • Author(s)
      Masayuki Nomoto, Isamu Taiko, Chika Takano, Kazunori Kanemaru, Toshio Miki
    • Organizer
      第100回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] ヒト羊膜上皮細胞を用いたⅡ型肺胞上皮細胞への分化誘導2023

    • Author(s)
      野本 正幸, 太向 勇, 高野 智圭, 金丸 和典, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] The first Japanese case of DNAJC12-deficiency: novel mutations and 18 years of follow-up for mHPA2023

    • Author(s)
      Erika Ogawa, Chika Takano, Natsuko Ichinoi, Mika Ishige, Takashi Hamazaki, Hideo Sasai, Ichiro Morioka
    • Organizer
      第64回日本先天代謝異常学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023

    • Author(s)
      高野智圭, 堀江真史, エルディーブ ダリア, 早川 智, 三木敏生
    • Organizer
      第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Single-cell transcriptomes reveal phylogenetic diversification of human amniotic epithelial cells2023

    • Author(s)
      Chika Takano, Masafumi Horie, Dahlia Eldeeb, Isamu Taiko, Toshio Miki
    • Organizer
      IPITA-IXA-CTRMS Joint Congress 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] 急性代謝不全症状を呈したY435Cホモ変異最軽症型プロピオン酸血症の幼児例2023

    • Author(s)
      高野智圭、小川えりか、市野井那津子、渡邉和宏、石毛信之、石毛美夏、森岡一朗
    • Organizer
      第126回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] フェニルケトン尿症における食事療法が幼児期の腸内細菌叢に及ぼす影響2023

    • Author(s)
      大海なつき、高野智圭、小川えりか、市野井那津子、石毛美夏、森岡一朗
    • Organizer
      第126回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] ヒト羊膜上皮細胞における幹細胞特性維持機構の解明2023

    • Author(s)
      高野 智圭, 加賀 三鈴, 太向 勇, 樋口 雄介, 三木 敏生
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Causative gene expressions of metabolic diseases on human amniotic epithelial cells2023

    • Author(s)
      Chika Takano, Naoto Kuki, Yutaka Furuta, Erika Ogawa, Mika Ishige, Toshio Miki
    • Organizer
      第64回日本先天代謝異常学会総会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] In vitro effects of 5-aminolevulinic acid on infantile mitochondrial disease caused by FBXL4 mutation2023

    • Author(s)
      Chika Takano, Ryo Ikuta, Erika Ogawa, Kazunori Kanemaru, Natsuko Ichinoi, Satoshi Hayakawa, Ichiro Morioka, Mika Ishige
    • Organizer
      44th Annual meeting of the Society for Inherited Metabolic Disorders
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] シングルセル解析を用いたヒト羊膜上皮細胞の系統学的多様性の解明2023

    • Author(s)
      高野智圭, 堀江真史, エルディーブ ダリア, 早川 智, 三木敏生
    • Organizer
      第31回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K15421
  • [Presentation] Mechanism of stemness maintenance in human amniotic epithelial cells2023

    • Author(s)
      Chika Takano, Millei Kaga, Isamu Taiko, Yusuke Higuchi, Toshio Miki
    • Organizer
      第100回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] 一過性メチルマロン酸血症を呈した 3-メチルクロトニルCoAカルボキシラーゼ欠損症の一例2022

    • Author(s)
      高野智圭, 小川えりか, 市野井那津子, 石毛信之, 森岡一朗, 石毛美夏
    • Organizer
      第49回日本マススクリーニング学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] Expression of Traf2- and Nck-interacting kinase in EMT-inhibited human amniotic epithelial cells2022

    • Author(s)
      Chika Takano, Toshio Miki
    • Organizer
      The Transplantation Society 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] FBLX4変異による乳児ミトコンドリア病における5-アミノレブリン酸効果のin vitro解析2022

    • Author(s)
      高野智圭, 生田稜, 小川えりか, 金丸和典, 市野井那津子, 早川智, 森岡一朗, 石毛美夏
    • Organizer
      第63回日本先天代謝異常学会総会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] Expression of Traf2- and Nck-interacting kinase in EMT-inhibited human amniotic epithelial cells2022

    • Author(s)
      Chika Takano、Toshio Miki
    • Organizer
      29th International Congress of The Transplantation Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24398
  • [Presentation] Comparison of laboratory- and clinical-grade reagents in isolation and cultivation of human amniotic epithelial cells2022

    • Author(s)
      Chika Takano, Isamu Taiko, Remi Kuwabara, Ibrahim Fathi, Toshio Miki
    • Organizer
      The Transplantation Society 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] 脂肪酸代謝異常症におけるアレルギー疾患の検討2022

    • Author(s)
      高野智圭, 小川えりか, 市野井那津子, 石毛美夏, 岩間元子, 浦上達彦, 森岡一朗
    • Organizer
      第125回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] Inhibition of epithelial mesenchymal transition maintains stemness in human amniotic epithelial cells2021

    • Author(s)
      Chika Takano, Masafumi Horie, Toshio Miki
    • Organizer
      Joint IXA-CTRMS Virtual Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17522
  • [Presentation] ヒト羊膜上皮細胞における上皮間葉転換と多能性に関する網羅的遺伝子解析2021

    • Author(s)
      高野智圭、堀江真史、早川 智、三木敏生
    • Organizer
      第29回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K17522
  • 1.  MIKI Toshio (80845305)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 2.  三角 浩司 (00442682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  淵本 大一郎 (10343998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  大西 彰 (30414890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  太向 勇 (20836556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  戸子台 和哲 (50581641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  早川 智 (30238084)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  相澤 修 (10645899)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  相澤 志保子 (30513858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  竹田 善紀 (50825239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  川名 敬 (60311627)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  高田 和秀 (60848711)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  荒木 慶彦 (70250933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TRINH DUYQUANG (90647190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KANEMARU Kazunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  堀江 真史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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