Hiraki Hayato 開勇人

Researcher Number	50847358
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 医歯薬総合研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 岩手医科大学, 医歯薬総合研究所, 助教 2019 – 2021: 岩手医科大学, 医歯薬総合研究所, 任期付助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator がん細胞 / 薬剤耐性 / カルシウムポンプ / カルシウムチャネル / がん細胞株 / 薬剤抵抗性 / カルシウムシグナル / 腫瘍内遺伝子変異不均一性 / がん / リキッドバイオプシー … More / crDNA / 逆相タンパクアレイ / カルシウム / RPPA / 治療標的分子 / Ca2+シグナル / ライブイメージング / 癌細胞 / real-time PCR / 癌細胞株 / 5-FU … More Except Principal Investigator ctDNAモニタリング / 骨髄浸潤 / B細胞リンパ腫 / 悪性リンパ腫 / 腫瘍マーカー / 血中DNA / リキッドバイオプシー / 血中腫瘍由来循環DNA / therapy / cancer / ctDNA Less

Detection of tumour clones in relapse after treatment of bone marrow involvement in malignant lymphomas.
- Principal Investigator
  
  阿保亜紀子 (八嶋亜紀子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
腫瘍内遺伝子変異不均一性に対応した超高感度ctDNAモニタリング方法の開発Principal Investigator
- Principal Investigator
  
  開勇人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Elucidation of relapse type-dependent ctDNA dynamics on multiple tumor origins
- Principal Investigator
  
  Nishizuka Satoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Drug resistance and calcium signaling in cancer cell linePrincipal Investigator
- Principal Investigator
  
  Hiraki Hayato
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Iwate Medical University
Identifying a novel drug target related to calcium signaling in anti-cancer drug resistant cellsPrincipal Investigator
- Principal Investigator
  
  Hiraki Hayato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Iwate Medical University

All 2024 2023 2022

All Journal Article Presentation Patent

[Journal Article] The Clinical Validity of Urinary Pellet DNA Monitoring for the Diagnosis of Recurrent Bladder Cancer2024
- Author(s)
  Abe Masakazu、Hiraki Hayato、Tsuyukubo Takashi、Ono Sadahide、Maekawa Shigekatsu、Tamura Daichi、Yashima-Abo Akiko、Kato Renpei、Fujisawa Hiromitsu、Iwaya Takeshi、Park Woong-Yang、Idogawa Masashi、Tokino Takashi、Obara Wataru、Nishizuka Satoshi S.
- Journal Title
  
  The Journal of Molecular Diagnostics
  
  Volume: 26 Issue: 4 Pages: 278-291
- DOI
  10.1016/j.jmoldx.2024.01.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-22K09457, KAKENHI-PROJECT-21K07223
[Journal Article] Postoperative recurrence detection using individualized circulating tumor <scp>DNA</scp> in upper tract urothelial carcinoma2023
- Author(s)
  Tamura Daichi、Abe Masakazu、Hiraki Hayato、Sasaki Noriyuki、Yashima‐Abo Akiko、Ikarashi Daiki、Kato Renpei、Kato Yoichiro、Maekawa Shigekatsu、Kanehira Mitsugu、Takata Ryo、Maejima Kazuhiro、Sasagawa Shota、Fujita Masashi、Suzuki Yutaka、Nakagawa Hidewaki、Iwaya Takeshi、Nishizuka Satoshi S.、Obara Wataru
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 2 Pages: 529-539
- DOI
  10.1111/cas.16025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09434, KAKENHI-PROJECT-21K07223, KAKENHI-PROJECT-21K09353
[Journal Article] Circulating Cell-Free DNA as a Biomarker for Prognosis and Response to Systemic Therapy in Patients with Unresectable Hepatocellular Carcinoma2023
- Author(s)
  Watanabe Takuya、Suzuki Yuji、Kuroda Hidekatsu、Hiraki Hayato、Suzuki Akiko、Tamura Akio、Ieko Yoshiro、Nishizuka Satoshi S.、Matsumoto Takayuki
- Journal Title
  
  Oncology
  
  Volume: 101 Issue: 11 Pages: 714-722
- DOI
  10.1159/000531671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07223
[Patent] がんの診断のためのプローブ／プライマーライブラリー2022
- Inventor(s)
  開勇人、西塚哲
- Industrial Property Rights Holder
  株式会社クオントディテクト
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Tumor-informed frequent ctDNA monitoring confirms the clinical validity in advanced cancer therapy2024
- Author(s)
  Nishizuka SS, Hiraki H, Yashima-Abo A, Sasaki T, Fujiwara R, Sasaki N, Inaba T, Sasaki T, Yaegashi M, Iwaya T
- Organizer
  2024 Circulating Nucleic Acids in Plasma and Serum (CNAPS2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] 食道癌日常診療におけるCGP検査とctDNAモニタリング2024
- Author(s)
  遠藤史隆，岩谷　岳，開　勇人，阿保亜紀子，板持広明，西塚　哲
- Organizer
  第8回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] アーカイブ組織を用いたOTS-アッセイのための病理学的検討およびその応用2024
- Author(s)
  阿保亜紀子，開　勇人，岩谷　岳，西塚　哲
- Organizer
  第8回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] 経尿道的膀胱腫瘍切除術の周術期血漿circulating tumor DNAの動態2024
- Author(s)
  阿部正和,開　勇人,田村大地,前川滋克,小原　航,西塚　哲
- Organizer
  第8回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Development and optimization of the off-the-shelf digital PCR primer/probe library for ctDNA monitoring2024
- Author(s)
  Hiraki H, Yashima-Abo A, Iwaya T, Nishizuka SS
- Organizer
  2024 Circulating Nucleic Acids in Plasma and Serum (CNAPS2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Digital PCRを用いた微小な遠隔転移を有する大腸癌のctDNAモニタリング2024
- Author(s)
  大塚歓喜，八重樫瑞典，梅邑　晃，片桐弘勝，遠藤史隆，開　勇人，阿保亜紀子，岩谷　岳，西塚　哲，新田浩幸，佐々木章
- Organizer
  第8回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] ヒトがん高頻度変異を対象としたdPCRプライマー・プローブライブラリOTS-1000exの利用可能性と現状2024
- Author(s)
  開　勇人，阿保亜紀子，岩谷　岳，西塚　哲
- Organizer
  第8回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] The usefulness of ctDNA and exosome DNA as biomarkers in esophageal squamous cell carcinoma2023
- Author(s)
  Nakai T, Kitahata Y, Nakamura Y, Motobayashi H, Takemoto N, Ojima T, Hayata K, Iwaya T, Hiraki H, Nishizuka SS, Kawai M
- Organizer
  The 82nd Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Tumor-informed ctDNA monitoring in daily practice for patients with esophageal cancer2023
- Author(s)
  Endo F, Iwaya T, Hiraki H, Abo A, Itamochi1 H, Nishizuka SS
- Organizer
  The 82nd annual meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] The clinical validity of urinary pellet DNA monitoring of recurrent bladder cancer2023
- Author(s)
  Abe M, Hiraki H, Tsuyukubo T, Ono S, Maekawa S, Tamura D, Ikarashi D, Kato R, Matsuura T, Kanehira M, Takata R, Fujisawa H, Iwaya T, Idogawa M, Obara W, Nishizuka SS
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] The clinical validity of tumor-informed ctDNA monitoring using a library of 1,000 dPCR primer/probe sets2023
- Author(s)
  Nishizuka SS, Hiraki H, Yashima-Abo A, Iwaya T
- Organizer
  European Liquid Biopsy Society General Assembly
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] 薬剤抵抗性胃がん細胞株における5-フルオロウラシル誘導性カルシウムシグナルの急激な減少2023
- Author(s)
  開勇人、西塚　哲
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-20K16338
[Presentation] OTS-アッセイのための病理学的検討およびその応用2023
- Author(s)
  阿保亜紀子,開勇人,岩谷岳,西塚哲
- Organizer
  第43回日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Analysis of the "off-the-shelf" digital-PCR primer/probe library, OTS-1000ex for the evaluation of clinical usability2023
- Author(s)
  Hiraki H, Iwaya T, Nishizuka S
- Organizer
  The 82nd annual meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] Prediction of treatment response by ctDNA monitoring in recurrent metastatic head and neck cancer2023
- Author(s)
  Kogo R, Manako T, Hiraki H, Nishizuka SS, Tange S, Idogawa M, Tokino T, Nakagawa T
- Organizer
  The 82nd Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] がん患者診療におけるCirculatingtumorDNA検査の意義2023
- Author(s)
  岩谷岳,遠藤史隆,八重樫瑞典,佐々木教之,佐々木智子,藤澤良介,開勇人,阿保亜紀子,板持広明、西塚哲
- Organizer
  第61回日本癌治療学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] A digital-PCR primer/probe library for pan-cancer ctDNA monitoring established from public databases for somatic mutations2023
- Author(s)
  Hiraki H, Yashima-Abo A, Iwaya T, Nishizuka SS
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223
[Presentation] An introduction of a highly sensitive circulating tumor DNA monitoring system for minimal residual disease detection using a library of 1000 digital PCR probes2023
- Author(s)
  Nishizuka SS, Hiraki H, Abe M, Yashima-Abo A, Iwaya T
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07223

1. Nishizuka Satoshi (50453311)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. 岩谷岳 (70405801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. 阿保亜紀子 (80326686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 古和田周吾 (30418884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKATA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 時野隆至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小原航

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 兼平貢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hiraki Hayato 開 勇人

Research Projects

Research Products

Co-Researchers

Detection of tumour clones in relapse after treatment of bone marrow involvement in malignant lymphomas.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍内遺伝子変異不均一性に対応した超高感度ctDNAモニタリング方法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of relapse type-dependent ctDNA dynamics on multiple tumor origins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug resistance and calcium signaling in cancer cell linePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifying a novel drug target related to calcium signaling in anti-cancer drug resistant cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The Clinical Validity of Urinary Pellet DNA Monitoring for the Diagnosis of Recurrent Bladder Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postoperative recurrence detection using individualized circulating tumor <scp>DNA</scp> in upper tract urothelial carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating Cell-Free DNA as a Biomarker for Prognosis and Response to Systemic Therapy in Patients with Unresectable Hepatocellular Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Patent] がんの診断のためのプローブ／プライマーライブラリー2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Tumor-informed frequent ctDNA monitoring confirms the clinical validity in advanced cancer therapy2024

Author(s)

Organizer

Data Source

[Presentation] 食道癌日常診療におけるCGP検査とctDNAモニタリング2024

Author(s)

Organizer

Data Source

[Presentation] アーカイブ組織を用いたOTS-アッセイのための病理学的検討およびその応用2024

Author(s)

Organizer

Data Source

[Presentation] 経尿道的膀胱腫瘍切除術の周術期血漿circulating tumor DNAの動態2024

Author(s)

Organizer

Data Source

[Presentation] Development and optimization of the off-the-shelf digital PCR primer/probe library for ctDNA monitoring2024

Author(s)

Organizer

Data Source

[Presentation] Digital PCRを用いた微小な遠隔転移を有する大腸癌のctDNAモニタリング2024

Author(s)

Organizer

Data Source

[Presentation] ヒトがん高頻度変異を対象としたdPCRプライマー・プローブライブラリOTS-1000exの利用可能性と現状2024

Hiraki Hayato 開勇人