ARAKAKI Naokatu 新垣尚捷

… Alternative Names

新垣尚捷アラカキナオカツ

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Researcher Number	60151148
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 准教授 1998 – 2003: The University of Tokushima Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 1993 – 1998: 鹿児島大学, 歯学部, 助教授 1991: 鹿児島大学, 歯学部, 助教授 1990: 鹿児島大学, 歯学部, 講師 1986: 徳島大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Cell biology / Functional basic dentistry / Biological pharmacy / Biological Sciences Except Principal Investigator Functional basic dentistry / Functional biochemistry / Science and Engineering / 広領域 / Functional biochemistry
Keywords	Principal Investigator 肝細胞増殖因子 / ミトコンドリア / 初代培養肝細胞 / 細胞内情報伝達機構 / caspase / interleukin-1beta converting enzyme / hepatocyte growth factor / apoptosis / human gingival epithelial cells / human junctional epithelial cells … More / カスパーゼ / アポトーシス / 歯肉上皮細胞 / 接合上皮細胞 / Signal transduction / Protein-tyrosine phosphatase / Hepatocyte growth factor receptor / Hepatocyte growth factor / Primary cultured hepatocytes / チロシンホスファターゼ / 肝細胞増殖因子受容体 / 国際情報交換 / シグナル伝達 / ＡＴＰ受容体 / ＡＴＰ / 抗肥満薬 / 細胞内中性脂肪 / 脂肪細胞 / Ｆ１Ｆｏ-ＡＴＰ合成酵素 / H^+-ATP合成酵素 / 癌転移 / 血管新生阻害剤 / 血管新生 / 血管内皮細胞 / 増殖因子受容体 … More Except Principal Investigator ミトコンドリア / MRSA / JVS / バイオジェネシス / ディスプレイ / ディファレンシャル / 細胞 / HeLa / 蛍光蛋白質 / 肝細胞 / flavone / 構造活性相関 / vraR ＆ vraS / フラボン / Hepatocyte growth factor / 肝細胞増殖因子 / Differential Display / JVSマウス / 遺伝子発現制御 / 肝疾患 / サイトカイン / 脾臓 / 細胞増殖 / 増殖因子 / two-components signal transduction system / structure-activity relationship / alkyl gallate / high throughput screening / intensifier of β-lactam-susceptibility / medicinal plants / ストレスに対する抵抗性 / 好気的エネルギー産生 / SAR解析 / ハイ・スループット・スクリーニング / β-ラクタム剤-感受性増強薬 / 生薬植物 / 親水性基と疎水性基 / 最適炭素鎖長 / 岩白菜 / 生薬 / 二成分系シグナルトランスダクション / アルキルガレート / ハイスループット・スクリーニング / β-ラクタム剤-感受性増強効果 / 薬用植物 / cytochrome / time-laps deconvolution / fusogen / biogenesis / mitochondrial reticulum / carnitin / JVS mouse / mitochondria / H^+-ATP合成酵素 / シトクロム / 形態形成 / フュソジェン / 網状ミトコンドリア / カルニチン / inducers of β-lactam-susceptibility in MRSA (ILSMR) / systemic infection in mice / two component signal transduction / differential hybridization / drug resistance / mecA / β-ラクタム剤耐性遺伝子 / 耐性遺伝子 / 転写制禦系 / PBP2' / mecA mRNA / two-component signal transduction system / vraS / vraR / β-ラクタム剤-感受性誘導薬 / b-ラクタム剤-感受性誘導薬 / MRSA感染マウス / two-comonentsignal transduction / Differential Hybridization / 薬剤耐性 / Tissue erpair / High sensitive ELISA / Gingival cervical fluid / Diagnosis / Periodontal disease / Scatter factor / 高感度化 / ELISA / SF / 歯周炎 / 歯肉溝滲出液 / HGF / 組織修復 / 高感度ELISA / 歯肉溝浸出液 / 診断法 / 歯周疾患 / 上皮細胞分散因子 / Osteoblast / Hepatocyte / Parathyroid hormone / Bone resorption / Serum concentration / Fetuin / Rat / 副甲状腺ホルモン / カテプシンL / ラットフェチュイン / α2-HS糖タンパク / 骨芽細胞 / 甲状腺ホルモン / 骨吸収 / 血清濃度 / フェチュイン / ラット / 唾液腺培養 / カルバコール / イソプロテレノール / 蛋白のリン酸化 / DNA合成 / ポリアミン合成酵素 / アミラーゼ分泌 / 耳下腺 / 細胞周期 / ディファレンシャルディスプレイ / HeLa細胞 / cDNAマイクロアレイ / 分子シンクロナイゼイション / ATP合成酵素 / 癌抑制因子 / 癌転移 / 肝臓 Less

Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthasePrincipal Investigator
- Principal Investigator
  
  ARAKAKI Naokatu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima
JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析
- Principal Investigator
  
  樋口富彦
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
ミトコンドリア増生の分子シンクロナイゼイションと新規蛋白質因子の解析
- Principal Investigator
  
  樋口富彦
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析
- Principal Investigator
  
  樋口富彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
TITLE OF PROJECT : Invention of intensifiers of antibiotics-susceptibility against multi-drugs resistant pathogenic bacteria and invesrigation for novel control system of multi-drugs resistance
- Principal Investigator
  
  HIGUTI Tomihiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  The University of Tokushima
血管新生をターゲットにした癌悪性化阻止戦略―血管内皮細胞膜に存在するH^+-ATP合成酵素阻害剤のスクリーニングと癌治療への応用―Principal Investigator
- Principal Investigator
  
  新垣尚捷
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Novel factors in the biogenesis of mitochondrial reticulum found from heart of juvenile visceral steatosis mouse
- Principal Investigator
  
  HIGUTI Tomihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
ATP合成酵素の分子構築における遺伝子制御の分子シンクロナイゼイション機構
- Principal Investigator
  
  HIGUTI Tomihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of "induces of β-lactam-susceptibility in MRSA (ILSMR)" and elucidaton of the novel regulatory mechanism
- Principal Investigator
  
  HIGUTI Tomihiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Studies for the induction of apoptosis in human junctional and gingival epithelial cells and for protective effect of HGF against apoptosis of these cellsPrincipal Investigator
- Principal Investigator
  
  ARAKAKI Naokatu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
  Kagoshima University
Physiological roles of rat fetuin on bone metabolism
- Principal Investigator
  
  DAIKUHARA Yasushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kagoshima University
A new diagnostic method for periodontal diseases by determining hepatocyte growth factor in gingival cervical fluid with a high sensitive ELISA.
- Principal Investigator
  
  DAIKUHARA Yasushi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kagoshima University
Physiological role of protein-tyrosine phosphatase which regulates the function of hepatocyte growth factor (HGF) receptorPrincipal Investigator
- Principal Investigator
  
  ARAKAKI Naokatu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  KAGOSHIMA UNIVERSITY
肝細胞増殖因子(HGF)受容体の多様性と細菌内情報伝達機構Principal Investigator
- Principal Investigator
  
  新垣尚捷
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kagoshima University
ヒト肝細胞増殖因子(hHGF)の合成・分泌調節機構
- Principal Investigator
  
  大工原恭
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
ヒト肝細胞増殖因子(hHGF)の合成・分泌調節機構
- Principal Investigator
  
  DAIKUHARA Yasushi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
耳下腺での分泌と酵素誘導の比較研究
- Principal Investigator
  
  井上秀夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima

All 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Contribution of extracellular ATP on the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol accumulation 2015
- Author(s)
 Kita Toshiyuki, Arakaki Naokatu
- Journal Title
 
 Biomed. Res.
 
 Volume: 36 Issue: 2 Pages: 115-120
- DOI
 10.2220/biomedres.36.115
- NAID
 130005065278
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-24590081
[Journal Article] Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum2014
- Author(s)
  Yamamoto Shinichiro, Arisa Yamashita, Naokatu Arakaki, Nemoto Hisao, Tetsuo Yamazaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 455 Issue: 3-4 Pages: 241-245
- DOI
  10.1016/j.bbrc.2014.10.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590081
[Journal Article] Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics2013
- Author(s)
  Naokatu Arakaki, Arisa Yamashita, Shingo Niimi, Tetsuo Yamazaki
- Journal Title
  
  Biomed. Res.
  
  Volume: 34 Issue: 3 Pages: 161-166
- DOI
  10.2220/biomedres.34.161
- NAID
  130004470847
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 細胞膜Ｆ１Ｆｏ-ＡＴＰ合成酵素を標的とする抗肥満薬の開2014
- Author(s)
  新垣尚捷
- Organizer
  平成２６年度上期ＤＳＡＮＪ疾患別商談会
- Place of Presentation
  大阪産業創造館（大阪府大阪市）
- Year and Date
  2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 水溶性ポリフェノール誘導体の中性脂肪減少効果とミトコンドリア融合活性2013
- Author(s)
  新垣尚捷
- Organizer
  第３５回　日本肥満学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 細胞膜ATP合成の脂質代謝における役割とミトコンドリアの融合・分裂の制御2012
- Author(s)
  新垣尚捷
- Organizer
  国立医薬品食品衛生試験所主催講演会
- Place of Presentation
  国立医薬品食品衛生試験所28号館　第一会議室（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] ミトコンドリア由来のROSシグナルは骨芽細胞の分化を誘導する2012
- Author(s)
  駒田致和、新垣尚捷、山崎哲男
- Organizer
  第５１回　日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学大会
- Place of Presentation
  島根県民会館・サンラポーむらくも（島根県）
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 細胞膜ATP合成のシグナル伝達とミトコンドリアの融合・分裂の制御2012
- Author(s)
  新垣尚捷
- Organizer
  奥羽大学薬学部主催講演会
- Place of Presentation
  奥羽大学薬学部棟２階523号室（福島県）
- Invited
- Data Source
  KAKENHI-PROJECT-24590081
[Presentation] 顕微鏡画像中におけるミトコンドリアの状態判別2012
- Author(s)
  新田和馬、寺田賢治、新垣尚捷
- Organizer
  ビジョン技術の実利用ワークショップ2012
- Place of Presentation
  パシフィコ横浜アネックスホール（神奈川県）
- Data Source
  KAKENHI-PROJECT-24590081

1. HIGUTI Tomihiko (50035557)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. SHIBATA Hirofumi (00093865)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. DAIKUHARA Yasushi (40028733)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 坪内博仁 (60145480)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 中河志朗 (70073666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 弘野修一 (00181222)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMAZAKI Tetsuo (90330208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. NEMOTO Hisao (30208293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TOMOMURA Akito (60188810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAMURA Osamu (70128445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATIGASHIRA Miho (80253897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHNISHI Tomokazu (30244247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUYAMA Takashi (40253900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 上野明道 (80136267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 井上秀夫 (30028732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SATO Youichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIKISHIMA Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ARAKAKI Naokatu 新垣 尚捷

新垣 尚捷 アラカキ ナオカツ

Research Projects

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Co-Researchers

Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthasePrincipal Investigator

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血管新生をターゲットにした癌悪性化阻止戦略―血管内皮細胞膜に存在するH^+-ATP合成酵素阻害剤のスクリーニングと癌治療への応用―Principal Investigator

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Studies for the induction of apoptosis in human junctional and gingival epithelial cells and for protective effect of HGF against apoptosis of these cellsPrincipal Investigator

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Physiological role of protein-tyrosine phosphatase which regulates the function of hepatocyte growth factor (HGF) receptorPrincipal Investigator

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Research Institution

肝細胞増殖因子(HGF)受容体の多様性と細菌内情報伝達機構Principal Investigator

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Project Period (FY)

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ARAKAKI Naokatu 新垣尚捷

新垣尚捷アラカキナオカツ

[Presentation] 細胞膜Ｆ１Ｆｏ-ＡＴＰ合成酵素を標的とする抗肥満薬の開2014