SUGIHARA Hitoshi 杉原仁

… Alternative Names

杉原仁スギハラヒトシ

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Researcher Number	60183414
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 日本医科大学, 大学院医学研究科, 大学院教授 2017: 日本医科大学, 医学部, 助教授 2017: 日本医科大学, 大学院医学研究科, 教授 2015: 日本医科大学, 医学(系)研究科(研究院), 教授 1999: NIPPON MEDICAL SCHOOL,DEPARTMENT OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助教授 … More 1998: 日本医科大学, 医学部, 講師 1993: 日本医科大学, 医学部, 助手 1988: Department of Medicine, Nippon Medical School, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Endocrinology / 内分泌・代謝学 Except Principal Investigator Experimental pathology / 内分泌・代謝学
Keywords	Principal Investigator ACTH / GHRH / ラット / モデルマウス / レプチン / 実験病理学 / マウス / 糖尿病 / 耐糖能異常 / 肥満 … More / 過食 / メタボリックシンドローム / RAT / GHRELIN / SOMATOSTATIN / GHS RECEPTOR (GHS-R) / GH SECRETAGOGUE (GHS) / GH RELEASING PEPTIDE (GHRP) / cyclic AMP (cAMP) / ソマトスタチン受容体 / 成長ホルモン分泌促進因子(GRF) / 成長ホルモン分泌促進ペプチド(GHRP) / ghrelin / GHS-R / GH / グレリン / ソマトスタチン / GHS-receptor(GHS-R) / GHS / GHRP / GH in RNA / 下垂体 / 成長ホルモン受容体 / 成長ホルモン(GH) … More Except Principal Investigator 2型糖尿病 / モデルマウス / 糖尿病 / CD36 / 脂肪酸 / β細胞 / 膵島 / インスリン分泌 / hypothalamic deafferentation / -endorphin / Growth Hormone-releasing factor / Somatostatin / 成長ホルモン / B-endorphin / 拍動性GH分泌 / β-endorphin / GRF / ソマトスタチン Less

Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in new model mice
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
Development of metabolic syndrome and feeding behavior: analysis in new model micePrincipal Investigator
- Principal Investigator
  
  SUGIHARA Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nippon Medical School
MODE OF ACTION OF GH RELEASING PEPTIDE(GHRP)/GH-SECRETA GOGUE(GUS) AND THE REGULATION OF PITUITARY GHS RECEPTOR(GHS-R)Principal Investigator
- Principal Investigator
  
  SUGIHARA Hitoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  NIPPON MEDICAL SCHOOL
成長ホルモン分泌促進因子遺伝子発現に対するリマトスタチンの効果Principal Investigator
- Principal Investigator
  
  杉原仁
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Nippon Medical School
A study on the role of somatostatin in the regulation of growth hormone secretion.
- Principal Investigator
  
  WAKABAYASHI Ichiji
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Nippon Medical School

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice2020
- Author(s)
  Asai Akira、Nagao Mototsugu、Hayakawa Koji、Miyazawa Teruo、Sugihara Hitoshi、Oikawa Shinichi
- Journal Title
  
  Diabetologia
  
  Volume: accepted
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08780
[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan Lou S.、Wendt Anna、Asai Akira、Sugihara Hitoshi、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2128 Pages: 25-54
- DOI
  10.1007/978-1-0716-0385-7_3
- ISBN
  9781071603840, 9781071603857
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan L.S.、Asai Akira、Ofori Jones K.、Edlund Anna、Wendt Anna、Sugihara Hitoshi、Wollheim Claes B.、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 6 Pages: 1193-1205
- DOI
  10.2337/db19-0944
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Fat intake and the development of type 2 diabetes [Review]2015
- Author(s)
  M Nagao, A Asai, H Sugihara, S Oikawa
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 7 Pages: 561-572
- DOI
  10.1507/endocrj.EJ15-0055
- NAID
  130005089858
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015
- Author(s)
  Nagao M, Asai A, Sugihara H, Oikawa S
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 4 Pages: 371-378
- DOI
  10.1507/endocrj.EJ14-0241
- NAID
  130005066937
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860300, KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Presentation] CD36によるβ細胞機能障害と糖尿病発症：Oikawa-Nagao(ON)マウスを端緒とした研究成果2020
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 新規耐糖能異常モデルマウスにおける過食・体重増加の規定因子：若齢期における低レプチンとその要因の探索2019
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第33回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 選抜交配によって新たに確立した高脂肪食誘発性耐糖能異常モデルマウスにおける過食、体重増加とレプチンシグナルとの関係2018
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加と脂肪組織におけるレプチン産生能との関係2018
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Reduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the β cells2017
- Author(s)
  Asai A, Nagao M, Tsuduki T, Miyazawa T, Esguerra JLS, Eliasson L, Sugihara H, Oikawa S
- Organizer
  European Association for the Study of Diabetes 53rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 膵島におけるCD36/FATの発現と脂肪酸動態、インスリン分泌能との関係：新規耐糖能異常モデルマウスを用いた解析2017
- Author(s)
  浅井明、長尾元嗣、都築毅、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加：若齢期におけるレプチン動態との関係2017
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホールヴィアマーレ（横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 膵島におけるCD36/FATの発現と脂肪酸動態、インスリン分泌能との関係：新規耐糖能異常モデルマウスを用いた解析2017
- Author(s)
  浅井明、長尾元嗣、都築毅、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Antiatherogenic effect of metformin in two mouse lines with different susceptibility to glucose intolerance2016
- Author(s)
  A Asai, M Nagao, M Kawahara, T Miyazawa, H Sugihara, S Oikawa
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Congress und Messe Innsbruck GmbH, Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 選抜交配による高脂肪食誘発性糖尿病モデルマウスの開発2016
- Author(s)
  浅井明、長尾元嗣、川原百代、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大学（兵庫県西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係：新規選抜交配モデルマウスの解析から2016
- Author(s)
  浅井明、長尾元嗣、川原百代、加藤俊治、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 選抜交配により作成した新規糖尿病モデルマウスの摂食行動に関する解析2015
- Author(s)
  長尾元嗣、浅井明、真山大輔、周東佑樹、小林俊介、杉原仁、及川眞一
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Spontaneous high fat diet overeating and body weight gain in selectively bred mice for diet-induced glucose intolerance: possible role of leptin2015
- Author(s)
  A Asai, M Nagao, H Sugihara, S Oikawa
- Organizer
  European Association for the Study of Diabetes 51st Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434

1. WAKABAYASHI Ichiji (10096662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. MINAMI Shiro (10192361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Asai Akira (30500011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 長尾元嗣 (10468762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. 都築毅 (00404848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

SUGIHARA Hitoshi 杉原 仁

杉原 仁 スギハラ ヒトシ

Research Projects

Research Products

Co-Researchers

Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in new model mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of metabolic syndrome and feeding behavior: analysis in new model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MODE OF ACTION OF GH RELEASING PEPTIDE(GHRP)/GH-SECRETA GOGUE(GUS) AND THE REGULATION OF PITUITARY GHS RECEPTOR(GHS-R)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成長ホルモン分泌促進因子遺伝子発現に対するリマトスタチンの効果Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the role of somatostatin in the regulation of growth hormone secretion.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice2020

Author(s)

Journal Title

Data Source

[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fat intake and the development of type 2 diabetes [Review]2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] CD36によるβ細胞機能障害と糖尿病発症：Oikawa-Nagao(ON)マウスを端緒とした研究成果2020

Author(s)

Organizer

Data Source

[Presentation] 新規耐糖能異常モデルマウスにおける過食・体重増加の規定因子：若齢期における低レプチンとその要因の探索2019

Author(s)

Organizer

Data Source

[Presentation] 選抜交配によって新たに確立した高脂肪食誘発性耐糖能異常モデルマウスにおける過食、体重増加とレプチンシグナルとの関係2018

Author(s)

Organizer

Data Source

[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加と脂肪組織におけるレプチン産生能との関係2018

Author(s)

SUGIHARA Hitoshi 杉原仁

杉原仁スギハラヒトシ