DOI Toshio 土井俊夫

Researcher Number	60183498
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2010 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2008: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2005 – 2006: The University of Tokushima, Graduate School Institute of Health Biosciences, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 2004 – 2006: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 … More 1999 – 2003: The Tokushima University, School of Medicine, Professor, 医学部, 教授 1994 – 1998: Kyoto University, Faculty of Medicine, Assistant Professor, 医学研究科, 講師 1993 – 1994: 京都大学, 医学部, 講師 1986: Kyoto University, Faculty of Medicine, Department of Pathology., 医学部・第二病理, 助手 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine Except Principal Investigator 内分泌・代謝学 / Kidney internal medicine / Laboratory medicine / Circulatory organs internal medicine / Kidney internal medicine / Metabolomics
Keywords	Principal Investigator メサンギウム細胞 / IV型コラーゲン / 転写因子 / 糸球体硬化症 / 糖尿病性腎症 / STAT3 / glomerulosclerosis / mesangial cell / MSW / TGF-β … More / 非酵素的糖化終末産物 / バイオマーカー / 遺伝子変異 / ポドサイト / 糖化終末産物 / 糖尿病 / リボザイム / 増殖 / complex trait disease / IgA nephropathy / Hemodialysis / Renal failure / Kidney / 慢性腎炎 / 日中共同研究 / 複合遺伝病 / IgA腎症 / 透析 / 慢性腎不全 / 腎臓 / vitamin K / warfarin / growth factor / Gas 6 / proliferation / Erk / 増殖抑制 / Gla化蛋白 / Axl / ビタミンK / 糸球体腎炎 / ワーファリン / 増殖因子 / Gas6 / promoter / transcription factor / 核転送 / プロモーター / ribozyme / HSP 47 / chaperone / DNA binding protein / type IV collagen / advanced glycation endproducts / glomerulonephritis / diabetic nephropathy / 強発現 / 腎症 / アンチセンス / シャベロン蛋白 / 受容体 / 熱ショック蛋白47 / シャロペン蛋白 / DNA結合蛋白 / Replication / Mesangial cells / Transcription factor / Collagen IV / Extracellular Matrix / Advanced Glycation / Diabetic Nephropathy / 平滑筋αアクチン / 細胞外基質 / ALK1 / エクソソーム / CKD / エクソゾーム / 慢性腎臓病 / 分子標的治療 / ALK3/6 / BMP / 抗体医療 / Sox9 / Smad1 / BMP4 / smooth muscle αactin / Id2 / bHLH型転写因子 / 形質変換 / ネフローゼ / 腎 / 糖尿病腎症 / HSP47 / RAGE / Id / E-box / bHLH / DNA複製因子C / 平滑筋細胞 / 分化 … More Except Principal Investigator VCAM-1 / Atherosclerosis / WHHLウサギ / Tリンパ球 / HB-EGF / 血管内皮細胞 / ネフローゼ症候群 / ポドサイト / 動脈硬化 / トランスジェニックマウス / nephrotic syndrome / 遺伝子変異 / octn2 / LOX-1 / HSP-70 / VLDL / MTP / 粥状動脈硬化 / LDL / マクロファージ / 単球接着分子 / 接着分子 / リゾフォスファチジルコリン / ICAM-1 / podocyte / バイオマーカー / 病理学 / 細胞・組織 / 老化 / 遺伝子 / ネフローゼ / 腎不全 / 肝細胞 / LDL受容体 / avidity / IgG4 subclass / anti-DNA antibodies / membranous nephropathy / lupus nephritis / antibody clonotypes / immune complexes / 等電点電気泳動 / 抗体の親和性 / IgG4サブクラス / 抗DNA抗体 / 膜性腎症 / ループス腎炎 / 抗体クロノタイプ / 免疫複合体 / linkage analysis / mutation / podocytes / 連鎖解析 / renal failure / gene / kidney / 腎糸球体上皮 / ゲノム / ポドドサイト / 腎臓 / fatty acid / 2-DG uptake / glucagon / JVS mouse / insulin / carintine transporter / carnitine / 膵ラ氏島 / 脂肪毒性 / 高血糖 / 長鎖脂肪酸 / 膵β細胞 / 脂肪酸 / 2-DG取り込み / グルカゴン / octn 2 / JVSマウス / インスリン / カルニチン輸送担体 / カルニチン / PI 3 kinase / MAP kinases / lysophosphatidylcholine / oxidezed LDL / IFN-γ / ERK / JNK / PECAM-1 / 酸化LDL受容体 / チロシンリン酸化 / 平滑筋細胞増殖因子 / 粥状動脈効果 / サイトカイン / PZ-3キナーゼ / 酸化LDC / シアストレス / TNF-2 / PI3キナーゼ / MAPキナーゼ / 酸化LDL / Transgenic mouse / Hepatocytes / CHO-cell / Apo B-protein / Cholesterol / 家族性高コレステロール血症 / 家族性複合型高脂血症 / HMG-CoA還元酵素阻害剤 / CHO-Cell / アポ蛋白B-100 / コレステロール / Transgeric Mouse / Knockout mouse / apo (a) / apolipoprotein E / Hyperlipidemia / 粥上動脈硬化 / ノックアウトマウス / アポ(a) / アポE / 高脂血症 / Tlymphocyte / WHHL-rabbit / Monocyte adhesion molecule / Macrophage / Vascular endothelial cell / Monocyte / 抗動脈硬化薬 / malotilate / 単クローン抗体 / 単球 / T-lymphocyte / P-selectin / lysophosphatidyl-choline / PDGF-A,B chain / endothelial cell / WHHL-ウサギ / 内皮細胞 / スカベンジャー受容体 / 泡沫細胞 / P selecTin / PDGF-A, B鎖 / P selection / リゾホスファチジルコリン / PDGF-A,B鎖 / 分子診断法 / 腎硬化症 / エクソゾーム / 予後予測マーカー / 予後 / 慢性腎臓病 / CKD / 糸球体硬化 / 腎臓病理 / 糸球体 / コレステロール代謝 / 選別輸送 Less

加齢ならびに高血圧による腎硬化症の分子診断法の開発
- Principal Investigator
  
  安部尚子
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima
Establishment of the scoring system for predicting the prognosis of CKD patients.
- Principal Investigator
  
  ABE Naoko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima
Establishment of non-invasive diagnostic method for CKD by using urinary exosomes.Principal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Development of Specific Biomarker and Molecular Targeting Therapy for Diabetic Nephropathy by RAS-independent PathwayPrincipal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
MOLECULAR MECHANISM OF GLOMERULOSCLEROSIS IN AGING
- Principal Investigator
  
  MATSUBARA Takeshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto University
Analysis of Candidate Genes within a New Disease Locus in Asian Patients with Steroid Resistance Nephrotic Syndrome
- Principal Investigator
  
  TSUKAGUCHI Hiroyasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kansai Medical University
  The University of Tokushima
MOLECULAR MECHANISMS OF GLOMERULOSCLEROSIS IN AGING
- Principal Investigator
  
  MATSUBARA Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto University
腎特異的な形質変換規定因子のクローニングと機能解析Principal Investigator
- Principal Investigator
  
  土井俊夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Gene Mapping for Familial Steroid Resistance Nephritic Syndrome
- Principal Investigator
  
  TSUKAGUCHI Hiroyasu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
ポドサイトの細胞認識と形態調節機能から探る腎糸球体硬化症発症の分子機構Principal Investigator
- Principal Investigator
  
  土井俊夫
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
An International Collaborative Study to investigate Genetic Susceptibility for chronic Kidney Disease Which is Common in AsianPrincipal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Molecular Pathogenesis of Hereditary Glomerulosclerosis.
- Principal Investigator
  
  TSUKAGUCHI Hiroyasu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
The Study of Progressive Factors to Developing Glomerular InjuryPrincipal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Is lipotoxicity caused by the intracellular accumulation ofacyl CoA ?
- Principal Investigator
  
  KUWAJIMA Masamichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
Hammer-head型リボザイムによる遺伝子発現抑制の腎疾患への応用Principal Investigator
- Principal Investigator
  
  土井俊夫
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
メサンギウム細胞分化を決定する新たな転写因子のクローニング-腎障害の形質変換における機能解析Principal Investigator
- Principal Investigator
  
  土井俊夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto University
Investigation for progressive factors of glomerulosclerosis.Principal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
  Kyoto University
Molecular mechanisms of atherogenesis
- Principal Investigator
  
  KITA Tooru
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Study on lipid metabolism and atherogenesis with transgenic mouse models
- Principal Investigator
  
  YOKODE Masayuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Development of new drug for intractable hyperlipidemia and its clinical application
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
発生工学を応用した小胞体輸送機構の研究-LDL受容体を発現するトランスジェニックマウスを用いて-
- Principal Investigator
  
  YOKODE Masayuki
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Study for model of diabetic nephropathy and prevention of disease progressPrincipal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KYOTO UNIVERSITY
Gene engineering, cell biological aproaches to the mechanisms for early stage of atherosclerosis
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Molecular Biological Study for the pathogenesis of glomerulosclerosisPrincipal Investigator
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KYOTO UNIVERSITY
Development and clinical application of novel anti-atherogenic drug.
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Detection of Specific Antibody Clonotypes in Various Immune Complex Glomerulonephritis.
- Principal Investigator
  
  TAMURA Tadao
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University

All 2013 2012 2011 2010 2009 2008 2007 2005

All Journal Article Presentation

[Journal Article] Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients2013
- Author(s)
  Yoshikawa K, Abe H, Tominaga T, Nakamura M, Kishi S, Matsuura M, Nagai K, Tsuchida K, Minakuchi J, Doi T
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 17 Issue: 6 Pages: 882-889
- DOI
  10.1007/s10157-013-0785-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy.2013
- Author(s)
  Nagai K1, Miyoshi M, Kake T, Fukushima N, Matsuura M, Shibata E, Yamada S, Yoshikawa K, Kanayama HO, Fukawa T, Yamaguchi K, Izaki H, Mima A, Abe N, Araoka T, Murakami T, Kishi F, Kishi S, Tominaga T, Moriya T, Abe H, Doi T.
- Journal Title
  
  PLoS One
  
  Volume: 8(6) Issue: 6 Pages: e66759-e66759
- DOI
  10.1371/journal.pone.0066759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659279
[Journal Article] Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1-smooth muscleαactin (SMA) signal transduction in diabetic nephropathy2012
- Author(s)
  Abe H, Tominaga T, Matsubara T, Abe N, Kishi S, Nagai K, Murakami T, Araoka T, Doi T.
- Journal Title
  
  J Biol Chem
  
  Volume: 287(24) Pages: 20430-20442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659279
[Journal Article] Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1-smooth muscle α actin(SMA) signal transduction in diabetic nephropathy2012
- Author(s)
  Abe H, Tominaga T, Matsubara T, Abe N, Kishi S, Nagai K, Murakami T, Araoka T, Doi T.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 24 Pages: 20430-20442
- DOI
  10.1074/jbc.m111.275610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-22390169, KAKENHI-PROJECT-23659445, KAKENHI-PROJECT-24591201, KAKENHI-PROJECT-24659279
[Journal Article] Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum2012
- Author(s)
  Kishi S, Yamada S, Kishi F, Shibata E, Matsuura M, Nagai K, Mima A, Abe H, Doi T.
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Issue: 16 Pages: 2197-2201
- DOI
  10.2169/internalmedicine.51.7919
- NAID
  130002062315
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] MPO-ANCA-positive anti-glomerular basement membrane antibody disease successfully treated byplasma exchange and immunosuppressive therapy.2011
- Author(s)
  Murakami T, Nagai K, Matsuura M, Kondo N, Kishi S, Araoka T, Kishi F, Sakiyama T, Mima A, Bando Y, Abe H, Doi T.
- Journal Title
  
  Ren Fail
  
  Volume: 33 Issue: 6 Pages: 626-631
- DOI
  10.3109/0886022x.2011.581401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Mixed Connective Tissue Disease Developing into MPO-ANCA-positive Polyangiitis2011
- Author(s)
  Murakami T, Endo S, Moriki T, Doi T, Matsumoto Y.
- Journal Title
  
  Intern. Med.
  
  Volume: 50 Issue: 6 Pages: 591-595
- DOI
  10.2169/internalmedicine.50.3958
- NAID
  130000649891
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker2011
- Author(s)
  Abe H, Matsubara T, Arai H, Doi T
- Journal Title
  
  Histol Histopathol.
  
  Volume: 26(4) Pages: 531-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808
[Journal Article] Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker2011
- Author(s)
  Abe H, Matsubara T, Arai H, Doi T
- Journal Title
  
  Histol Histopathol.
  
  Volume: 26 Pages: 531-541
- URL
  http://www.hh.um.es/Abstracts/Vol_26/26_4/26_4_531.htm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] SOX9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy2011
- Author(s)
  Kishi S, 著者8名省略, Matsubara T, 著者4名省略, Doi T
- Journal Title
  
  J Biol Chem
  
  Volume: 286(37) Pages: 32162-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808
[Journal Article] BMP4・Smad1シグナルと糖尿病性腎症2011
- Author(s)
  安部秀斉、冨永辰也, 松原雄, 土井俊夫
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 53(7) Pages: 1000-1005
- NAID
  10030343457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659445
[Journal Article] Sox9 induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy2011
- Author(s)
  Kishi S, Abe H, Akiyama H, Tominaga T, Murakami T, Mima A, Nagai K, Kishi F, Matsuura M, Matsubara T, Iehara N, Ueda O, Fukushima N, Jishage KI, Doi T.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(37) Issue: 37 Pages: 32162-9
- DOI
  10.1074/jbc.m111.244541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591032, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis2011
- Author(s)
  Mima A, 著者3名省略, Matsubara T, 著者6名省略, Doi T
- Journal Title
  
  PLoS One
  
  Volume: 6(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808
[Journal Article] Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy2011
- Author(s)
  Tominaga T, 著者5名省略, Matsubara T, 著者6名省略, Doi T
- Journal Title
  
  J Biol Chem
  
  Volume: 286(22) Pages: 20109-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808
[Journal Article] Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis2011
- Author(s)
  Mima A, Abe H, Nagai K, Arai H, Matsubara T, Araki M, Torikoshi K, Tominaga T, Iehara N, Fukatsu A, Kita T, Doi T
- Journal Title
  
  PLoS One.
  
  Volume: 6(3) Issue: 3 Pages: e17929-e17929
- DOI
  10.1371/journal.pone.0017929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] An autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with intestinal bleeding in chronic renal failure2011
- Author(s)
  Mima A, Shiota F, Matsubara T, Iehara N, Akagi T, Abe H, Nagai K, Matsuura M, Murakami T, Kishi S, Araoka T, Kishi F, Kondo N, Shigeta R, Yoshikawa K, Kita T, Doi T, Fukatsu A
- Journal Title
  
  Ren Fail.
  
  Volume: 33 Issue: 6 Pages: 622-625
- DOI
  10.3109/0886022x.2011.585730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390169
[Journal Article] Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy2011
- Author(s)
  Tominaga T, Abe H, Ueda O, Goto C, Nakahara K, Murakami T, Mima A, Nagai K, Araoka T, Kishi S, Fukushima N, Jishage KI, Doi T
- Journal Title
  
  J Biol Chem
  
  Volume: 286(22) Issue: 22 Pages: 20109-16
- DOI
  10.1074/jbc.m110.179382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590628, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Transcription factor 7-like 2(TCF7L2) regulates activin receptor-like kinase 1(ALK1)/ Smad1 pathway for development of diabetic nephropathy2010
- Author(s)
  Araoka T, Abe H, Tominaga T, Mima A, Matsubara T, Murakami T, Kishi S, Nagai K, Doi T
- Journal Title
  
  Mol Cells
  
  Volume: 30(3) Issue: 3 Pages: 209-218
- DOI
  10.1007/s10059-010-0109-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-21790808, KAKENHI-PROJECT-22390169
[Journal Article] Trophoblast glycoprotein : possible candidate mediating podocyte injuries in glomerulonephritis2010
- Author(s)
  Murakami T, Abe H, Nagai K, Tominaga T, Takamatsu N, Matsubara T, Araoka T, Kishi S, Takahashi T, Mima A, Takai Y, Kopp JB, Doi T.
- Journal Title
  
  Am J Nephrol
  
  Volume: 32(6) Issue: 6 Pages: 505-521
- DOI
  10.1159/000321366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591032, KAKENHI-PROJECT-21591033, KAKENHI-PROJECT-22390169
[Journal Article] Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis2009
- Author(s)
  Qin XS, Tsukaguchi H, Shono A, Yamamoto A, Kurihara H, Doi T.
- Journal Title
  
  J Am Soc Nephrol 20(12)
  
  Pages: 2534-2545
- Data Source
  KAKENHI-PROJECT-19590953
[Journal Article] Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains2009
- Author(s)
  Shono A, Tsukaguchi H, Kitamura A, Hiramoto R, Qin XS, Doi T, Iijima K.
- Journal Title
  
  Hum Mol Genet 18(16)
  
  Pages: 2943-2956
- Data Source
  KAKENHI-PROJECT-19590953
[Journal Article] The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy.2008
- Author(s)
  Doi T, Mima A, Matsubara T, et. al.
- Journal Title
  
  Diabetes Res Clin Pract. 82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790580
[Journal Article] The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy2008
- Author(s)
  Doi T, Mima A, Matsubara T, et.al.
- Journal Title
  
  Diabetes Res Clin Pract 82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790580
[Journal Article] Steroid-resistant nephrotic syndrome2008
- Author(s)
  Kitamura A, Tsukaguchi H, Maruyama K, Shono A, Iijima K, Kagami S, Doi T.
- Journal Title
  
  Kidney Int 74(9)
  
  Pages: 1209-1215
- Data Source
  KAKENHI-PROJECT-19590953
[Journal Article] Podocin participates in the assembly of tight junctions between foot processes in nephrotic podocytes2007
- Author(s)
  Shono A, Tsukaguchi H, Yaoita E, Nameta M, Kurihara H, Qin XS, Yamamoto T, Doi T.
- Journal Title
  
  J Am Soc Nephrol 18(9)
  
  Pages: 2525-2533
- Data Source
  KAKENHI-PROJECT-19590953
[Journal Article] SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells.2007
- Author(s)
  Sumi E, Iehara N, Akiyama H, Matsubara T, (6名省略), Doi T.
- Journal Title
  
  Am J Pathol. 170
  
  Pages: 1854-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790580
[Journal Article] A New Clinical Entity of Fragile Silt Membrane Nephrotic Syndrome in Which NPHS1 Variants Serve as a Predisposing Factor for Proteinuria.2005
- Author(s)
  Kitamura A, Iijima K, Tsukaguchi H, Hiramoto R, Shono A, Choi Y, Cheong HI, Doi T, Kagami S.
- Journal Title
  
  J Am Soc Nephrol 16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390245
[Journal Article] Raft-Dependent Endocytic Pathway of Nephrin Down-regulates Its Signal Transduction Through interaction with Src-Family Kinase Fyn.2005
- Author(s)
  Shono A, Tsukaguchi H, X-S Qin, Doi T.
- Journal Title
  
  J Am Soc Nephrol 16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390245
[Presentation] 腎機能低下予測バイオマーカーとしてのポドサイト由来エクソソーム内転写因子2013
- Author(s)
  安部尚子、安部秀斉、土井俊夫
- Organizer
  第53回日本臨床化学会年次学術集会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Data Source
  KAKENHI-PROJECT-24659279
[Presentation] 腎機能低下予測バイオマーカーとしてのポドサイト由来エクソソーム内転写因子2013
- Author(s)
  安部尚子、土井俊夫、安部秀斉
- Organizer
  第53回　日本臨床化学会年次学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Data Source
  KAKENHI-PROJECT-24659279
[Presentation] Multiple regulatory pathways of BMP-Smad axis through a sclerosis-specific basic HLH transcription factor in diabetic nephropathy2013
- Author(s)
  Yui Fujita, Akiko Sakurai, Tatsuya Tominaga, Sanae Hayashi, Naoko Abe, Toshio Doi, Hideharu Abe
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-24659279
[Presentation] Predictive biomarkers for kidney function declines: podocyte-derived exosomal transcriptional factors2012
- Author(s)
  安部尚子、林早苗、土井俊夫、安部秀斉
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-23659445
[Presentation] Predictive biomarkers for kidney function declines : podocyte-derived exosomal transcriptional factors2012
- Author(s)
  安部尚子、林早苗、土井俊夫、安部秀斉
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-24659279
[Presentation] 糸球体腎炎におけるCD44作用機序の解析2012
- Author(s)
  金井麻衣、冨永辰也、安部秀斉、美馬晶、林早苗、長井幸二郎、土井俊夫
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-23659445
[Presentation] 新規バイオマーカーとしての尿中エクソゾームによる慢性腎臓病患者の病態解析2011
- Author(s)
  安部尚子、安部秀斉、土井俊夫
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-23659445
[Presentation] PIASyはメサンギウム細胞においてE12と共役し<SMAの発現を制御する2011
- Author(s)
  鳥越和雄, 大島隆幸, 平野隆弘, 安部秀斉, 松雄, 荒木真, 家原典之, 深津敦司, 荒井秀典, 土井俊夫
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21790808
[Presentation] 低ナトリウム血症とその治療2011
- Author(s)
  松原雄, 家原典之, 土井俊夫
- Organizer
  第41回日本腎臓学会西部学術大会
- Place of Presentation
  徳島
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-21790808
[Presentation] 尿中エクソゾームを用いた慢性腎臓病の非侵襲的診断法と予後予測2011
- Author(s)
  林早苗、安部秀斉、冨永辰也、安部尚子、近藤直樹、土井俊夫
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23659445
[Presentation] Overexpression of Smad1 Causes Remarkable Glomerulosclerosis in Diabetic Mice2010
- Author(s)
  Takeshi Matsubara, Hideharu Abe, Otoya Ueda, Kou-ichi Jishage, Akira Mima, Chisato Goto, Tatsuya Tominaga, Makoto Araki, Kazuo Torikoshi, Kojiro Nagai, Noriyuki Iehara, Atsushi Fukatsu, Naoshi Fukushima, Hidenori Arai, Toshio Doi
- Organizer
  the American Diabetes Association's 70th Scientific Sessions
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-21790808

1. YOKODE Masayuki (20252447)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. KUME Noriaki (20252455)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. TSUKAGUCHI Hiroyasu (60335792)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
4. MIZUNO Akira (80219641)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. ABE Hideharu (60399342)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
6. KITA Toru (60161460)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. UEDA Yukihiko (70252434)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. IEHARA Noriyuki (20281727)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
9. MURAKAMI Takashi (40210009)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. NOMA Yoshihiko (10218349)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. ISHII Kenji (00212811)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
12. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
13. WAKATSUKI Yoshio (40220826)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. NAGAI Kojiro (40542048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
15. MIMA Akira (00432401)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
16. MURAKAMI Motonobu (10157761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. HAKAMATA Yasuhiro (30261233)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. MATSUBARA Takeshi (90422964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
19. ARAI Hidenori (60232021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
20. FUKATSU Atsushi (90247685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. TOMINAGA Tatsuya (80425446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
22. ABE Naoko (70623271)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
23. YANAGITA Motoko (70378769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KISHI Seiji (10519507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. SHIMABUKURO Michio (60271144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ISHIMURA Kazunori (90112185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. NAKAYA Yutaka (50136222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KAGAMI Shoji (00224337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. IIJIMA Kazumoto (00240854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. TAMURA Tadao (70026855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. MUSO Eri (10190852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. YOSHIDA Haruyoshi (80135574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 吉岡秀幸 (30231690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 堀内久徳 (90291426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. HAMAGUTHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. HARA Seijiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. MAEDA Nobuyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. RUBIN Edward M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. MATSUURA Motokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 村上太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

DOI Toshio 土井 俊夫

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Establishment of non-invasive diagnostic method for CKD by using urinary exosomes.Principal Investigator

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Development of Specific Biomarker and Molecular Targeting Therapy for Diabetic Nephropathy by RAS-independent PathwayPrincipal Investigator

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腎特異的な形質変換規定因子のクローニングと機能解析Principal Investigator

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ポドサイトの細胞認識と形態調節機能から探る腎糸球体硬化症発症の分子機構Principal Investigator

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An International Collaborative Study to investigate Genetic Susceptibility for chronic Kidney Disease Which is Common in AsianPrincipal Investigator

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The Study of Progressive Factors to Developing Glomerular InjuryPrincipal Investigator

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DOI Toshio 土井俊夫