Mikami Toshio 三上俊夫

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MIKAMI Toshio 三上俊夫

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Researcher Number	60199966
Other IDs
External Links
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 研究生 2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 日本医科大学, 大学院医学研究科, 研究生 2013 – 2022: 日本医科大学, 医学部, 准教授 2007 – 2011: Nippon Medical School, 医学部, 准教授 2005 – 2006: 日本医科大学, 医学部, 助教授 2002 – 2003: 日本医科大学, 医学部, 助教授 … More 1997 – 1998: 日本医科大学, 医学部, 講師 1995 – 1997: Department of Health and Physical Education, Nippon Medical School, Assistant Pr, 保健体育教室, 講師 1994: 日本医科大学, 第2生化学, 講師 1993 – 1994: 日本医科大学, 医学部, 講師 1992 – 1993: 日本医科大学, 第二生化学, 講師 1990: 日本医科大学, 医学部・第二生化学研究室, 助手 1988 – 1989: 日本医科大学, 医学部第二生化学研究室, 助手 Less
Review Section/Research Field	Principal Investigator 体育学 / Sports science / Basic Section 59020:Sports sciences-related / Sports science Except Principal Investigator 体育学 / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 運動 / ストレス / 認知機能 / 海馬 / IGF-1 / 神経新生 / ストレス耐性 / JB-1 / β-glucuronidase / 脳由来神経栄養因子 … More / ウォーターメイズテスト / 神経細胞 / mRNA / 熱ショックタンパク質70 / 運動トレーニング / NADH/NAD比 / IEGs / 乳酸 / Sirtuin 1 / eNAMPT / NAD / 加齢 / エピジェネテック / うつ病 / うつ様症状 / アデノシン受容体 / イノシン / 抗うつ / 不活動 / hippocampus / water maze test / IGF-1 receptor / spatial memory / exercise / stress / ウォーターメイズ / Akt / アストロサイト / 身体運動 / 記憶力 / 精神的ストレス / lactate dehydrogenase / exercise training / primary culture / creatine kinase / skeletal muscle damage / stress resistance / heat shock protein 70 / 伸長性筋収縮 / LDH / クレアチンキナーゼ活性 / β-グルクロニダーゼ活性 / ストレス抵抗性 / 乳酸脱水素酵素 / 初代培養肝細胞 / クレアチンキナーゼ / 筋損傷 / 神経由来栄養因子 / ミフェフリストン / 受容体 / アンタゴニスト / グル子コルチコイド / ミフェプリストン / 阻害剤 / グルココルチコイド / 高強度運動 / BDNF / VEGF / 血管新生 / 免疫組織学的分析 / Ki67 / 記憶学習能力 / 学習記憶能力 / isulin-like growth factor 1 / ストレス交叉性 / 熱ショックタンパク質 / ストレスタンパク質 / 激運動 / マウス / ウエスタンブロッティング / Taqman PCR法 / 高速液体クロマトグラフィー / 尿酸 / ヒポキサンチン / de novo合成 / プリン体代謝 / 高尿酸血症 / 平均赤血球比重 / 赤血球寿命 / 自発的運動 … More Except Principal Investigator 尿酸 / vitamin C deprivation / allantoin / uric acid / vitamin C / lipid peroxides / antioxidants / exercise / 抗酸化物質 / アラントイン / ビタミンC / 過酸化脂質 / 運動 / IMP reamination / AMP deamination / hadaidin / kidney / hyperuricemia / exercise-induced hyperuricemia / plasma uric acid concentration / 腎臓 / 賢臓 / 高尿酸血症 / 運動性高尿酸現象 / 血清尿酸値 / free radicals / potassium oxonate / 抗酸化物質;抗酸化作用 / 激運動 / 運動負荷 / TRAP / 水溶性ラジカル / ビタミンC欠乏 / 抗酸化作用 / Artemisia / 尿酸産生抑制剤(アロプリノール) / exhaustive運動時 / 尿酸比 / アラトイン / ビタミンE / キサンチンオキシダーゼ / スーパーオキサイド / Purine metabolism in liver / アデニンヌクレオチド / プリン代謝 / ^<15>N / IMPreamination / AMPdeamination / hadacidin / 筋中プリン代謝 / 肝中プリン代謝 / 認知・記憶障害 / 酸化ストレス / モデル動物 / 神経疾患の病態と治療 / 精神 Less

Whether blood lactate increased via high-intense exercise contributes to the improvement of cognitive function due to high-intensity exercise or not?Principal Investigator
- Principal Investigator
  
  三上俊夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
Does exercise prevent cognitive decline by suppressing the age-related decrease in hippocampal NAD+?Principal Investigator
- Principal Investigator
  
  三上俊夫
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
Whether exercise-induced antidepressant effects are regulated by inosine-mediated BDNF expression in the brain?Principal Investigator
- Principal Investigator
  
  Mikami Toshio
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Nippon Medical School
Dose glucocorticoid induce enhance hippocampal neurogenesis following a single bout of intense exercise?Principal Investigator
- Principal Investigator
  
  Mikami Toshio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Nippon Medical School
Dose regular exercise improve cognition or prevent onset of depression via enhancement of hippocampal angiogenesis?Principal Investigator
- Principal Investigator
  
  MIKAMI Toshio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Nippon Medical School
Protective effects of molecular hydrogen on a stress-induced brain dysfunction
- Principal Investigator
  
  OHSAWA Ikuroh
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nippon Medical School
Dose physical exercise prevent mental stress-induced impairment of hippocampal neurogenesis?Principal Investigator
- Principal Investigator
  
  MIKAMI Toshio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Nippon Medical School
Dose physical exercise prevent neuronal cell death induced by chronically psychological stress?Principal Investigator
- Principal Investigator
  
  MIKAMI Toshio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Nippon Medical School
Examination of exercise-induced accommodation in the transcription control of the heat shock protein (HSP7O) and biophylaxis functionPrincipal Investigator
- Principal Investigator
  
  MIKAMI Toshio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Nippon Medical School
運動負荷マウス由来の単離培養肝細胞での熱ショックタンパク質(HSP70)発現の検討Principal Investigator
- Principal Investigator
  
  三上俊夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  体育学
- Research Institution
  Nippon Medical School
Preventing the formation of active oxygen during exercise
- Principal Investigator
  
  ITO Akira
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
運動性高尿酸血症の発症機序に関する研究-プリン体のde novo合成よりの検討-Principal Investigator
- Principal Investigator
  
  三上俊夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  体育学
- Research Institution
  Nippon Medical School
Preventing the formation of active oxygen during exercise
- Principal Investigator
  
  ITO Akira
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
赤血球の細胞年齢に及ぼす持久的運動トレーニングの影響Principal Investigator
- Principal Investigator
  
  三上俊夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  体育学
- Research Institution
  Nippon Medical School
The studies of purine metabolism during exercise to used ^<15>N-stable-isotope
- Principal Investigator
  
  ITO Akira
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
Mechanism Exercise-induced Hyperuricemia
- Principal Investigator
  
  ITO Akira
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Institute of Health and Sports Science University of Tsukuba

All 2019 2012 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice2012
- Author(s)
  Kiuchi T, Lee H, Mikami T
- Journal Title
  
  Neuroscience
  
  Volume: 207 Pages: 208-217
- DOI
  10.1016/j.neuroscience.2012.01.023
- Data Source
  KAKENHI-PROJECT-21500637
[Journal Article] Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice.2010
- Author(s)
  Nakajima, S., Ohsawa, I., Ohta, S., Ohno, M., Mikami, T.
- Journal Title
  
  Behav. Brain Res. 211
  
  Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500345
[Journal Article] Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory.2009
- Author(s)
  Nakajima, S., Ohsawa, I., Nagata, K., Ohta, S., Ohno, M., Ijichi, T., Mikami, T.
- Journal Title
  
  Behav. Brain Res. 200
  
  Pages: 15-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500345
[Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.2009
- Author(s)
  Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., Ohta, S.
- Journal Title
  
  Neuropsycopharmacology 34
  
  Pages: 501-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500345
[Journal Article] Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory2009
- Author(s)
  Nakajima S., Ohsawa I, Nagata K., Ohta S., Ohno M., Ijichi T. Mikami T.
- Journal Title
  
  Behavioural Brain Research 200
  
  Pages: 15-21
- Data Source
  KAKENHI-PROJECT-19500570
[Journal Article] Voluntary exercise had recovery against immobilization stress-induced damages of brain function and spatial learning.2007
- Author(s)
  Sanae Nakajima, Kazufumi Nagata, Makoto Ohno and Toshio Mikami
- Journal Title
  
  The 29th Asian Federation of Sports Medicine Congress(AFSM) 10
  
  Pages: 18-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500570
[Presentation] 継続的運動は不活動由来の認知機能低下とうつ様症状の発症を予防する2019
- Author(s)
  三上俊夫
- Organizer
  第74回日本板力医学会大会
- Data Source
  KAKENHI-PROJECT-16K01737
[Presentation] 身体運動が神経新生と学習記憶能力に与える影響をIGF-1との関係から考察する2009
- Author(s)
  三上俊夫
- Organizer
  第23回日本体力医学会近畿地方会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19500570
[Presentation] Protective effect of exercise on stress-induced impairment of spatial memory is dependent on IGF-12008
- Author(s)
  Toshio Mikami, Sanae Nakajima
- Organizer
  13th Annual Congress European College of Sport Science
- Place of Presentation
  Estoril
- Data Source
  KAKENHI-PROJECT-19500570
[Presentation] 抗酸化物質の摂取は拘束による記憶学習能力の低下を抑制する2007
- Author(s)
  中島早苗, 永田和史, 大野誠, 三上俊夫
- Organizer
  第74回日本体力医学会総会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19500570

1. OHTA Shigeo (00125832)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. ITO Akira (80056639)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TAZAKI Yousuke (30114101)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 荒川亮介 (40350095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 渡辺光博 (10450842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHSAWA Ikuroh (30343586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 金芝美 (00868177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 朴ジョンヒョク (80835843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mikami Toshio 三上 俊夫

MIKAMI Toshio 三上 俊夫

Research Projects

Research Products

Co-Researchers

Whether blood lactate increased via high-intense exercise contributes to the improvement of cognitive function due to high-intensity exercise or not?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Does exercise prevent cognitive decline by suppressing the age-related decrease in hippocampal NAD+?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Whether exercise-induced antidepressant effects are regulated by inosine-mediated BDNF expression in the brain?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dose glucocorticoid induce enhance hippocampal neurogenesis following a single bout of intense exercise?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dose regular exercise improve cognition or prevent onset of depression via enhancement of hippocampal angiogenesis?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protective effects of molecular hydrogen on a stress-induced brain dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dose physical exercise prevent mental stress-induced impairment of hippocampal neurogenesis?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dose physical exercise prevent neuronal cell death induced by chronically psychological stress?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Examination of exercise-induced accommodation in the transcription control of the heat shock protein (HSP7O) and biophylaxis functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

運動負荷マウス由来の単離培養肝細胞での熱ショックタンパク質(HSP70)発現の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preventing the formation of active oxygen during exercise

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

運動性高尿酸血症の発症機序に関する研究-プリン体のde novo合成よりの検討-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preventing the formation of active oxygen during exercise

Principal Investigator

Project Period (FY)

Mikami Toshio 三上俊夫

MIKAMI Toshio 三上俊夫