KUGA Keisuke 久賀圭祐

Researcher Number	60241816
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2018: 筑波大学, 医学医療系, 教授 2007: University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor 2006: 筑波大学, 大学院人間総合科学研究科, 助教授 1995 – 1996: 筑波大学, 臨床医学系, 講師
Review Section/Research Field	Principal Investigator Applied health science / Applied health science Except Principal Investigator Special needs education / Circulatory organs internal medicine / Clinical psychology
Keywords	Principal Investigator 高血圧 / 線維化 / 炎症反応 / 細胞外マトリックス / 心筋線維化 / ケモカイン / SREBP-1 / 肥満 / 脂肪性肝疾患 / 運動療法 … More / 転写因子 / エンドトキシン / 炎症・酸化ストレス / 脂肪性肝炎 / 酸化ストレス / Nrf2 / 運動実践 / 遺伝子改変マウス / 非アルコール性脂肪性肝疾患 / 運動治療 / 酸化ストレス応答性転写因子 / 遺伝子ノックインマウス / 抗酸化ストレス応答 / 脂肪肝 / 身体活動 / 体力医学 / クッパー細胞 / 異物貪食機能 / 炎症応答 / LPS / TNF-Like Weak Inducer / 肝組織障害 … More Except Principal Investigator 不整脈 / arrhythmia / 障害学生支援 / 合理的配慮 / 共生社会 / 発達障害 / 心肥大 / 伸展刺激応答イオンチャンネル / 自律神経 / 機械的収縮 / 電気的興奮 / フィードバック / フィードバック機構 / 肥大心 / Cardiac hypertrophy / stretch acfivated ion channel / antonomic nerves / mechanical contraction / excitation / 自律訓練法 / 自律神経機能 / 心房細動 / ローレンツ・プロット / 治療効果 / 心臓疾患 / 練習効果 / autogenic training / cardiac autonomic function / atrial fibrillation / Lorenz plot Less

Exercise improves obesity-related liver disease through a reduction of tissue damaging factor, TWEAK by the activation Nrf2.Principal Investigator
- Principal Investigator
  
  Kuga Keisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  University of Tsukuba
Interdisciplinary research of reasonable accommodation on academic support for students with disabilities
- Principal Investigator
  
  TAKEDA Kazunori
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Special needs education
- Research Institution
  University of Tsukuba
Role of SREBP-1 on the development of hypertesive heart diseasePrincipal Investigator
- Principal Investigator
  
  KUGA Keisuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  University of Tsukuba
The effects of Autogenic training as a psychological intervention for cardiac disease.
- Principal Investigator
  
  SUGIE Masashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Tsukuba
肥大心における機械的収縮、電気的興奮のフィードバック機構の不整脈発生に対する関与-Stretch activated channel の関与と自律神経が与える影響について-
- Principal Investigator
  
  YAMAGUCHI Iwao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Institute of Clinical Medicine, University of Tsukuba

All 2018 2017 2016 2014 2013 2012 2011 2007

All Journal Article Presentation

[Journal Article] Radiofrequency Catheter Ablation of Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy and Apical Aneurysm.2018
- Author(s)
  Igarashi M, Nogami A, Kurosaki K, Hanaki Y, Komatsu Y, Fukamizu S, Morishima I, Kaitani K, Nishiuchi S, Talib AK, Machino T, Kuroki K, Yamasaki H, Murakoshi N, Sekiguchi Y, Kuga K, Aonuma K
- Journal Title
  
  JACC Clin Electrophysiol
  
  Volume: 4 Pages: 339-350
- DOI
  10.1016/j.jacep.2017.12.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03255
[Journal Article] What kinds of factors affect the academic outcomes of university students with mental disorders? A retrospective study based on medical records.2018
- Author(s)
  Ishii Terumi, Tachikawa Hirokazu, Shiratori Yuki, Hori Takafumi, Aiba Miyuki, Kuga Keisuke, Arai Tetsuaki
- Journal Title
  
  Asian J Psychiatr
  
  Volume: 32 Pages: 67-72
- DOI
  10.1016/j.ajp.2017.11.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26245086, KAKENHI-PROJECT-16H03255
[Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016)　― Digest Version ―2018
- Author(s)
  umitomo N, Baba R, Doi S, Higaki T, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H (et al. )
- Journal Title
  
  Circulation Journal
  
  Volume: 82 Issue: 9 Pages: 2385-2444
- DOI
  10.1253/circj.cj-66-0153
  10.1253/circj.CJ-66-0153
- NAID
  130007438850
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17K10140, KAKENHI-PROJECT-18K07813, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-16K08866, KAKENHI-PROJECT-16K19627
[Journal Article] 高周波ホットバルーンカテーテルによる右上肺静脈焼灼中に肺静脈電位ならびに上大静脈電位の電気的隔離が観察された発作性心房細動の1例.2018
- Author(s)
  安達　亨，山﨑　浩，小松雄樹，橋本直明，山上　文，篠田康俊，芳沢礼佑，服部　愛，蔡　榮鴻，増田慶太，町野　毅，黒木健志，関口幸夫，久賀圭祐，野上昭彦，青沼和隆
- Journal Title
  
  臨床心臓電気生理
  
  Volume: 41 Pages: 205-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03255
[Journal Article] Crucial role of pulmonary vein firing as an initiator of typical atrial flutter: Evidence of a close relationship between atrial fibrillation and typical atrial flutter.2017
- Author(s)
  Kaneshiro T, Yoshida K, Sekiguchi Y, Tada H, Kuroki K, Kuga K, Kamiyama Y, Suzuki H, Takeishi Y, Aonuma K
- Journal Title
  
  J Arrhythmia
  
  Volume: 32 Pages: 67-72
- DOI
  10.1016/j.joa.2016.07.013
- NAID
  120007129021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03255
[Journal Article] Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles2017
- Author(s)
  Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 12902-12902
- DOI
  10.1038/s41598-017-12926-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19887, KAKENHI-PROJECT-17K19888, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H04281, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-17H02174, KAKENHI-PROJECT-16K14589, KAKENHI-PROJECT-16K15188, KAKENHI-PUBLICLY-16H01630
[Journal Article] Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis2017
- Author(s)
  Komine S, Akiyama K, Warabi E, Oh S, Kuga K, Ishige K, Togashi S, Yanagawa T, Shoda J
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 11977-11977
- DOI
  10.1038/s41598-017-12358-8
- NAID
  120007134775
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19887, KAKENHI-PROJECT-17K19888, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H04935, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-16H05220, KAKENHI-PROJECT-17H02174, KAKENHI-PROJECT-16K15188
[Journal Article] Long‐Term Prognosis of Brugada‐Type ECG and ECG With Atypical ST‐Segment Elevation in the Right Precordial Leads Over 20 Years: Results From the Circulatory Risk in Communities Study (CIRCS).2016
- Author(s)
  Hidekazu Tsuneoka, Masahiko Takagi, Nobuyuki Murakoshi, Kazumasa Yamagishi, Yasuhiro Yokoyama, DongZhu Xu, Yukio Sekiguchi, Hiro Yamasaki, Yoshihisa Naruse, Yoko Ito, Miyako Igarashi, Akihiko Kitamura, Takeo Okada, Takeshi Tanigawa, Keisuke Kuga,et al.
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 5
- DOI
  10.1161/jaha.115.002899
- NAID
  120007135251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03255
[Journal Article] β1-Adrenergic receptor Arg389Gly polymorphism affects the antiarrhythmic efficacy of flecainide in patients with coadministration of β-blockers.2016
- Author(s)
  Doki Kosuke, Sekiguchi Yukio, Kuga, Keisuke, Aonuma Kazutaka, Homma Masato.
- Journal Title
  
  Pharmacogenetics and Genomics
  
  Volume: 26 Pages: 481-485
- DOI
  10.1097/fpc.0000000000000239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03255
[Journal Article] Stereoselective analysis of flecainide enantiomers using reversed-phase liquid chromatography for assessing CYP2D6 activity2014
- Author(s)
  Doki K, Sekiguchi Y, Kuga K, Aonuma K, Kohda Y, Homma M.
- Journal Title
  
  Biomed Chromatogr
  
  Volume: in press
- DOI
  10.1002/bmc.3143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Journal Article] 医療従事者を目指す障害学生への支援の現状と課題―筑波大学における聴覚障害学生への支援事例をもとに―2014
- Author(s)
  田原敬・有海順子・和田哲郎・久賀圭祐・竹田一則
- Journal Title
  
  リハビリテーション研究
  
  Volume: 160 Pages: 9-14
- Data Source
  KAKENHI-PROJECT-26245086
[Journal Article] SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients.2014
- Author(s)
  Doki K, Homma M, Kuga K, Aonuma K, Kohda Y.
- Journal Title
  
  Pharmacogenet Genomics.
  
  Volume: 23 Pages: 349-354
- DOI
  10.1097/fpc.0b013e328361fb8d
- NAID
  120007136378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Journal Article] Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy2014
- Author(s)
  Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, Kuga K, Mizutani T, Aonuma K, Miyauchi T.
- Journal Title
  
  Life Sciences
  
  Volume: 102 Pages: 98-104
- DOI
  10.1016/j.lfs.2014.03.018
- NAID
  120007136696
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-23592025, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25293125, KAKENHI-PROJECT-25670757
[Journal Article] Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy2014
- Author(s)
  Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, Kuga K, Mizutani T, Aonuma K, Miyauchi T
- Journal Title
  
  Life Sci
  
  Volume: 102 Pages: 98-104
- NAID
  120007136696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Journal Article] SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients2013
- Author(s)
  Doki K, Homma M, Kuga K, Aonuma K, Kohda Y
- Journal Title
  
  Pharmacogenet Genomics
  
  Volume: 23 Pages: 349-354
- NAID
  120007136378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Journal Article] Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease2012
- Author(s)
  Miyauchi Y, Sakai S, Maeda S, Shimojo N, Watanabe S, Homma S, Kuga K, Aonuma K, Miyauchi T
- Journal Title
  
  Life Sci
  
  Volume: 91 Pages: 729-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Journal Article] Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymeraseII2012
- Author(s)
  Sakai S, Kimura T, Wang Z, Shimojo N, Maruyama H, Homma S, Kuga K, Yamaguchi I, Aonuma K, Miyauchi T
- Journal Title
  
  Life Sci
  
  Volume: 91 Pages: 572-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500835
[Presentation] スルフォラファンによる転写因子Nrf2の賦活化は，運動耐容能を向上させる2017
- Author(s)
  小峰昇一，呉世昶，蕨栄治，久賀圭祐，正田純一
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-16H03255
[Presentation] 継続的運動はDHEA産生によりKupffer細胞（KCs）の貪食能を向上させ，生体のLPSのクリアランス増大と炎症応答の低下を誘導する2017
- Author(s)
  小峰昇一，秋山健太郎，蕨栄治，久賀圭祐，正田純一
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-16H03255
[Presentation] 精神科通院学生の学業転帰についてー12年間のまとめー2016
- Author(s)
  石井映美・太刀川弘和・佐々木恵美・久賀圭祐・新井哲明
- Organizer
  全国大学保健管理研究集会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Data Source
  KAKENHI-PROJECT-26245086
[Presentation] Elevated Blood Pressure in Resting Daytime‐Phase in A170/SQSTM1‐Knockout Mice, a Newly Established Obese Model2013
- Author(s)
  Sakai S, Warabi E, Yanagawa T, Kimura T, Tajiri K, Wang Z, Maruyama H, Homma S, Kuga K, Aonuma K, Miyauchi T, Ishii T.
- Organizer
  13th International Conference on Endothelin
- Place of Presentation
  筑波大学東京キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-23500835
[Presentation] Sterol regulatory element-binding protein-1 is involved in the development of angiotensin II-induced cardiac fibrosis2012
- Author(s)
  Sakai S, Nakagawa N, Shimojo N, Kumura T, Tajiri K, Kuga K, Homma S, Miyauchi T, Aonuma K, Shimano H
- Organizer
  Basic Cardiovascular Sciences Conference
- Place of Presentation
  米国ニューオリンズ
- Year and Date
  2012-07-24
- Data Source
  KAKENHI-PROJECT-23500835
[Presentation] Involvement of Sterol Regulatory Element Binding Protein-1 (SREBP-1) in Angiotensin II-Induced Cardiac Injury via Chronic Inflammatory Responses2012
- Author(s)
  Sakai S, Nakagawa Y, Shimojo N, Kuga K, Homma S, Shimano H, Aonuma K
- Organizer
  第76回日本循環器学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23500835
[Presentation] Sterol Regulatory Element-Binding Protein-1 Participates in the Development of Cardiac Injury via Chronic Inflammation2011
- Author(s)
  Sakai S, Nakagawa Y, Shimojo N, Kuga K, Homma S, Miyauchi T, Shimano H, Aonuma K
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  米国オーランド
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-23500835
[Presentation] 抗不整脈薬および肺静脈隔離術に抵抗性の発作性心房細動に対に自律訓練法が著効した1例2007
- Author(s)
  久賀圭祐, 杉江征, 他
- Organizer
  第64回日本循環器心身医学会
- Place of Presentation
  日本教育会館
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18530531
[Presentation] Autonomic Training Completely Prevented Recurrence of Paroxysmal Atrial Fibrillation Resistant to Drugs and Catheter Ablation2007
- Author(s)
  K, Kuga. K., Sugie. M., Matsui. M., Kodama. M., Yamazaki, H., Akiyama, D., Higuchi. T., Machino. T., Koyama. T., Sekiguchi, Y., & Aonuma, k.
- Organizer
  The 65th Annual Convention of Japanese Society of Psychosomatic Cardiology
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18530531
[Presentation] 抗不整脈薬および肺静脈隔離術に抵抗性の発作性心房細動に対して自律訓練法が著効した1例2007
- Author(s)
  久賀圭祐・杉江征・松井めぐみ・小玉正博・山崎浩・秋山大樹・樋口甚彦・町野毅・小山崇・関口幸夫・青沼和隆
- Organizer
  第64回日本循環器心身医学会
- Place of Presentation
  東京,日本教育会館
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18530531

1. SAKAI Satoshi (30282362)

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# of Collaborated Products: 8 results
2. SHIMANO Hitoshi (20251241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. SUGIE Masashi (70222049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. TAKEDA Kazunori (90261768)

# of Collaborated Projects: 1 results

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5. YAMAGUCHI Iwao (30111389)

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6. MIYAUCHI Takashi (60222329)

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7. KODAMA Masahiro (00114075)

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46. JU Yeong-sil

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47. IGUCHI Akiko

# of Collaborated Projects: 1 results

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48. OKUMURA Maiko

# of Collaborated Projects: 1 results

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49. KAWAMINAMI Sawako

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50. NAKASHIMA Noriko

# of Collaborated Projects: 1 results

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51. MANASE Youhei

# of Collaborated Projects: 1 results

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52. KATO Yoshiaki

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53. SHIMOJO Nobutake

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54. HOMMA Satoshi

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55. KIMURA Taizo

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56. 山本雅之

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57. 石井功

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58. 三輪佳宏

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59. 溝上裕士

# of Collaborated Projects: 0 results

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60. 堀江稔

# of Collaborated Projects: 0 results

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61. 三谷義英

# of Collaborated Projects: 0 results

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62. 澤田博文

# of Collaborated Projects: 0 results

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63. 堀米仁志

# of Collaborated Projects: 0 results

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64. 田尻和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUGA Keisuke 久賀 圭祐

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Exercise improves obesity-related liver disease through a reduction of tissue damaging factor, TWEAK by the activation Nrf2.Principal Investigator

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Interdisciplinary research of reasonable accommodation on academic support for students with disabilities

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Role of SREBP-1 on the development of hypertesive heart diseasePrincipal Investigator

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The effects of Autogenic training as a psychological intervention for cardiac disease.

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肥大心における機械的収縮、電気的興奮のフィードバック機構の不整脈発生に対する関与-Stretch activated channel の関与と自律神経が与える影響について-

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[Journal Article] Radiofrequency Catheter Ablation of Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy and Apical Aneurysm.2018

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[Journal Article] What kinds of factors affect the academic outcomes of university students with mental disorders? A retrospective study based on medical records.2018

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[Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―2018

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[Journal Article] 高周波ホットバルーンカテーテルによる右上肺静脈焼灼中に肺静脈電位ならびに上大静脈電位の電気的隔離が観察された発作性心房細動の1例.2018

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[Journal Article] Crucial role of pulmonary vein firing as an initiator of typical atrial flutter: Evidence of a close relationship between atrial fibrillation and typical atrial flutter.2017

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[Journal Article] Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles2017

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[Journal Article] Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis2017

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[Journal Article] Long‐Term Prognosis of Brugada‐Type ECG and ECG With Atypical ST‐Segment Elevation in the Right Precordial Leads Over 20 Years: Results From the Circulatory Risk in Communities Study (CIRCS).2016

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[Journal Article] β1-Adrenergic receptor Arg389Gly polymorphism affects the antiarrhythmic efficacy of flecainide in patients with coadministration of β-blockers.2016

KUGA Keisuke 久賀圭祐

[Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016)　― Digest Version ―2018