HIRANO Fuminori 平野史倫

Researcher Number	60250552
External Links
Affiliation (based on the past Project Information) *help	1999 – 2011: 旭川医科大学, 医学部, 講師 1998: 旭川医科大学, 医学部, 助手 1994 – 1995: 旭川医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Gastroenterology / Gastroenterology / 内科学一般 Except Principal Investigator Gastroenterology
Keywords	Principal Investigator NF-κB / IAP-1 / farnesoid X receptor / 発現制御 / 臨床 / 核酸 / 免疫学 / シグナル伝達 / 転写因子 / 胆汁酸 … More / apoptosis / bile acid / アポトーシス / RANTES / gene regulation / clinical research / nucleic acids / immunology / signal transduction / cell proliferation / cyclin D1 / caspases / サイクリン / 抗アポトーシス / p65 / 細胞増殖 / famesoid X receptor / サイクリンD1 / カスパーゼ / chemokine / transcription factor / Farnesoid X receptor / ケモカイン / 滑膜炎 / 関節リウマチ / リウマチ病学 / Bcl-3 / p52 / p50 / インターロイキン4 / 血管内皮細胞 / P-セレクチン / Sp1 / protein kinase C / 主要組織適合抗原 / MHC class I / 原発性胆汁性肝硬変 / 胆汁うっ滯 / ケノデオキシコール酸 / ウルソデオキシコール酸 … More Except Principal Investigator MHC / gastroenterology / molecular biology / immunology / transcription factors / bile acids / プロテインキナーゼC / MHC class I / T細胞 / グルココルチコイド / 免疫応答 / 消化器病学 / 分子生物学 / 転写因子 / 免疫学 / 胆汁酸 Less

マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究Principal Investigator
- Principal Investigator
  
  平野史倫
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Asahikawa Medical College
Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.Principal Investigator
- Principal Investigator
  
  HIRANO Fuminori
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Asahikawa Medical College
Establishment of new treatment in rheumatoid arthritis under controlling nuclear factor KB activation.Principal Investigator
- Principal Investigator
  
  HIRANO Fuminori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Asahikawa Medical College
Study of bile acid-modulated cell apoptosis and regeneration in liverPrincipal Investigator
- Principal Investigator
  
  HIRANO Fuminori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Study of bile acid-modulated immune response through transcription factorsPrincipal Investigator
- Principal Investigator
  
  HIRANO Fuminori
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
血管内皮細胞における接着分子P-セレクチンの遺伝子発現調節機構の解明-炎症性疾患の新規治療法創生をめざしてPrincipal Investigator
- Principal Investigator
  
  平野史倫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Asahikawa Medical College
肝・胆管細胞における胆汁酸の主要組織適合抗原遺伝子の発現調節機構の解明-自己免疫性肝胆道疾患の病態解明と治療法の確立-Principal Investigator
- Principal Investigator
  
  平野史倫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
STUDY ON THE IMMUNOMODURATORY ACTION OF BILE ACIDS
- Principal Investigator
  
  MAKINO Isao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  ASAHIKAWA MEDICAL COLLEGE

All 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] "呼吸器合併症のスクリーニング検査について" ファーマナビゲーターシリーズ「リウマチ～生物学的製剤編～」(竹内勤編集)2010
- Author(s)
  平野史倫
- Publisher
  メディカルレビュー社(印刷中)
- Data Source
  KAKENHI-PROJECT-19591749
[Book] "臨床症状-腺外症状-甲状腺病変" シェーグレン症候群の診断と治療マニュアル(住田孝之、江口勝美編集)2009
- Author(s)
  平野史倫
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] 呼吸器合併症のスクリーニング検査について2010
- Author(s)
  平野史倫
- Journal Title
  
  ファーマナビゲーターシリーズ「リウマチ～生物学的製剤編～」 (印刷中)
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] 呼吸器合併症のスクリーニング検査について2010
- Author(s)
  平野史倫
- Journal Title
  
  ファーマナビゲーターシリーズ「リウマチ～生物学的製剤編～」
  
  Pages: 162-164
- Data Source
  KAKENHI-PROJECT-22591674
[Journal Article] 臨床症状-腺外症状-甲状腺病変2009
- Author(s)
  平野史倫
- Journal Title
  
  シェーグレン症候群の診断と治療マニュアル
  
  Pages: 132-137
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity2009
- Author(s)
  Takahashi K, Hirano F, Matsumoto K, Aso K, Haneda M.
- Journal Title
  
  Pancreas 38(1)
  
  Pages: 49-57
- NAID
  10025227995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] 禁煙を科学する「喫煙による内分泌代謝機能への影響」2008
- Author(s)
  平野史倫
- Journal Title
  
  綜合臨床 57(8)
  
  Pages: 2149-2152
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] 特集「禁煙を科学する」喫煙による内分泌代謝機能への影響2008
- Author(s)
  平野史倫, 羽田勝計
- Journal Title
  
  綜合臨床 57(8)
  
  Pages: 2149-2152
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] 特集「古くて新しい胆汁酸最近の話題」胆汁酸による転写因子活性化機構2007
- Author(s)
  平野史倫
- Journal Title
  
  臨床化学 36(3)
  
  Pages: 205-214
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] Effect of thrombin on RANKL expression in T cells : Correlation between thrombin receptor (ThrR) expression and prognostic factor of joint destruction in rheumatoid arthritis (RA) patients2006
- Author(s)
  Hirano F
- Journal Title
  
  Mod Rheumatol 16
  
  Pages: 203-203
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Effect of thrombin on RANKL expression in T cells : Correlation between thrombin receptor (ThrR) expression and prognostic facto of joint destruction in rheumatoid arthritis (RA) patients2006
- Author(s)
  Hirano F
- Journal Title
  
  Mod Rheumatol 16
  
  Pages: 203-203
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Effect of thrombin on RANKL expression in T cells : Correlation between thrombin receptor (ThrR) expression and prognostic factor of joint destruction in rheumatoid arthritis (RA) patients.2006
- Author(s)
  Hirano F, et al.
- Journal Title
  
  Mod Rheumatol 16
  
  Pages: 203-203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes2006
- Author(s)
  Hirano F
- Journal Title
  
  J Gastroenterol Hepatol 21 (12)
  
  Pages: 1807-1813
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes.2006
- Author(s)
  Hirano F, et al.
- Journal Title
  
  J Gastroenterol Hepatol 21(12)
  
  Pages: 1807-1813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Bile acid induces anti-apoptotic cIAP-1 expression in human hepatocytes : possibility on rescues from hepatocyte apoptosis in cholestatic liver diseases.2005
- Author(s)
  Hirano F
- Journal Title
  
  World J Gastroenterol (in press)
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] Relation between thrombin receptor (ThrR) expression and prognostic factor of joint destruction in RA patients- 3 years follow-up study.2005
- Author(s)
  Hirano F
- Journal Title
  
  Mod Rheumatol 15
  
  Pages: 283-283
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes2005
- Author(s)
  Hirano F
- Journal Title
  
  J Gastroenterol Hepatol (in press)
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Bile acid induces anti-apoptotic clAP-1 expression in human hepatocytes : possibility of rescues from hepatocyte apoptosis in cholestatic liver diseases.2005
- Author(s)
  Hirano F
- Journal Title
  
  World J Gastroenterol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] Relation between thrombin receptor (ThrR) expression and prognostic factor of joint destruction in RA patients-3 years follow-up study.2005
- Author(s)
  Hirano F, et al.
- Journal Title
  
  Mod Rheumatol 15
  
  Pages: 283-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] Bile acid induces anti-apoptotic cIAP-1 expression in human hepatocytes : possibility of rescues from hepatocyte apoptosis in cholestatic liver diseases.2005
- Author(s)
  Hirano F
- Journal Title
  
  World J Gastroenterol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] Relation between thrombin receptor (ThrR) expression and prognosti factor of joint destruction in RA patients- 3 years follow-up study2005
- Author(s)
  Hirano F
- Journal Title
  
  Mod Rheumatol 15
  
  Pages: 283-283
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591544
[Journal Article] アジソン病2004
- Author(s)
  平野史倫
- Journal Title
  
  臨床看護 30(6)
  
  Pages: 828-830
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] TNF-α induced RANTES chemokine expression via activation of NF-κB and p38 MAP kinase : roles of TNF-α in alcoholic liver diseases.2003
- Author(s)
  Hirano F
- Journal Title
  
  J Hepatol. 38(4)
  
  Pages: 483-489
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] アポトーシスの転写因子、特にNF-κBについて2003
- Author(s)
  平野史倫
- Journal Title
  
  肝胆膵 46(1)
  
  Pages: 7-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] TNF-α induced RANTES chemokine expression via activation of NF-κB and p38 MAP kinase : roles of TNF-α in alcoholic liver diseases.2003
- Author(s)
  Hirano F
- Journal Title
  
  J Hepatol 38(4)
  
  Pages: 483-489
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] Inhibition of TNF-α-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs.2003
- Author(s)
  Hirano F
- Journal Title
  
  Int Immunopharmacol. 3(2)
  
  Pages: 225-232
- NAID
  120006658752
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Journal Article] Inhibition of TNF-α-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs.2003
- Author(s)
  Hirano F
- Journal Title
  
  Int Immunopharmacol 3(2)
  
  Pages: 225-232
- NAID
  120006658752
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590614
[Presentation] Treatment of symptomatic hand osteoarthritis by risedronate in postmenopausal osteoporotic women.2011
- Author(s)
  Fuminori Hirano
- Organizer
  European Congress on Osteoporosis&Osteoarthritis
- Place of Presentation
  Valencia, Spain
- Data Source
  KAKENHI-PROJECT-22591674
[Presentation] Effect of leukocytapheresis on inflammatory cytokine expressions in response to lipopolysaccharide in peripheral blood mononuclear cells of etanercept-resistant rheumatoid arthritis.2010
- Author(s)
  Fuminori Hirano
- Organizer
  The 54^<st> Annual Scientific Meeting of the Japan College of Rheumatology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-22591674
[Presentation] The relationship between osteoporosis and breast arterial calcification in Japanese nostmenonausal women.2010
- Author(s)
  Fuminori Hirano
- Organizer
  1st Asia-Pacific Osteoporosis Meeting
- Place of Presentation
  Singapore Singapore
- Data Source
  KAKENHI-PROJECT-22591674
[Presentation] Effectiveness of leukocytapheresis for etanercept-resistant rheumatoid arthritis : Decreased responsiveness to lipopolysaccharide-induced stimulation of inflammatory cytokines in peripheral blood mononuclear cells.2009
- Author(s)
  平野史倫
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] エタネルセプト効果減弱関節リウマチ患者における白血球除去療法の有効性とその作用機序に関する検討2009
- Author(s)
  平野史倫
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Glucocorticoid and TNF-α additively up-regulate RANKL mRNA expression in human osteoblast-like cells : Influence of glucocorticoid treatment on generalized osteoporosis in rheumatoid arthritis.2009
- Author(s)
  Fuminori Hirano
- Organizer
  Annual Meeting of, the International Bone & Min eral Society (IBMS2009)
- Place of Presentation
  Sydney, AUSTRALIA
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Glucocorticoid and tumor necrosis factor-α additively up-regulate RANKL mRNA expression in human osteoblast-like cells : Influence of glucocorticoid treatment on generalized osteoporosis in rheumatoid arthritis2009
- Author(s)
  F. Hirano
- Organizer
  2^<nd> Joint Meeting of International Bone & Mineral Society
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Effectiveness of leukocytapheresis for etanercept-resistant rheumatoid arthritis : Decreased responsiveness to lipopolysaccharide-induced stimulation of inflammatory cytokines in peripheral blood mononuclear cells2009
- Author(s)
  F. Hirano
- Organizer
  Annual European Congress of Rheumatology (EULAR2009)
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] 膠原病における甲状腺自己抗体の出現頻度に関する検討2009
- Author(s)
  平野史倫
- Organizer
  第52回日本甲状腺学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Dexamethasone additively increases TNFα-induced RANKL mRNA expression in RA fibroblast-like svnoviocvtes2008
- Author(s)
  Fulninori Hirano
- Organizer
  The 52^<st> Annual Scientific Meeting of the Japan College of Rheumatology
- Place of Presentation
  Sapporo, JAPAN
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Parathyroid hormone and glucocorticoid cooperatively induce RANKL mRNA expression in osteoblasts through different mechanisms2008
- Author(s)
  Fuminori Hirano
- Organizer
  10th European Congress of Endocrinology
- Place of Presentation
  Berlin, GERMANY
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Parathyroid hormone and glucocorticoid cooperatively induce RANKL mRNA expression in osteoblasts through different mechanisms2008
- Author(s)
  F. Hirano
- Organizer
  10th European Congress of Endocrinology
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] RA線維芽滑膜細胞におけるTNFαとステロイドによるRANKL発現調節機構に関する検討2008
- Author(s)
  平野史倫
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] The homeodomain transcription factor CDX2 inhibits human pancreatic cancer cell proliferation by repressing cyclin D1 transcription.2007
- Author(s)
  Fuminori Hirano
- Organizer
  15th United European Gastroenterology Week "UEGW 2007"
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Increased expression of synovial RANKL is associated with joint destruction in rheumatoid arthritis.2007
- Author(s)
  Fuminori Hirano
- Organizer
  The 51st Annual Scientific Meeting of the Japan College of Rheumatology
- Place of Presentation
  Yokohama, JAPAN
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Regulation of RANKL expression by glucocorticoid. in human osteoblast-like cells.2007
- Author(s)
  Fuminori Hirano
- Organizer
  The 29th Annual Meeting of the American Society for Bone and Mineral Researxh
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] RA線維芽滑膜細胞におけるRANKLと osteoprotegerin 発現の検討2007
- Author(s)
  平野史倫
- Organizer
  第51回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591749
[Presentation] Regulation of RANKL Expression by Glucocorticoid in Human Osteoblast-like Cells2007
- Author(s)
  F. Hirano
- Organizer
  29th Annual Meeting of American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-19591749

1. MAKINO Yuichi (90345033)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. OKAMOTO Kensaku (80396879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MAKINO Isao (60088854)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUKAWA Etsushi (60322913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANAKA Hirotoshi (00171794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRANO Fuminori 平野 史倫

Research Projects

Research Products

Co-Researchers

マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new treatment in rheumatoid arthritis under controlling nuclear factor KB activation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of bile acid-modulated cell apoptosis and regeneration in liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of bile acid-modulated immune response through transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管内皮細胞における接着分子P-セレクチンの遺伝子発現調節機構の解明-炎症性疾患の新規治療法創生をめざしてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝・胆管細胞における胆汁酸の主要組織適合抗原遺伝子の発現調節機構の解明-自己免疫性肝胆道疾患の病態解明と治療法の確立-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY ON THE IMMUNOMODURATORY ACTION OF BILE ACIDS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] "呼吸器合併症のスクリーニング検査について" ファーマナビゲーターシリーズ「リウマチ～生物学的製剤編～」(竹内勤編集)2010

Author(s)

Publisher

Data Source

[Book] "臨床症状-腺外症状-甲状腺病変" シェーグレン症候群の診断と治療マニュアル(住田孝之、江口勝美編集)2009

Author(s)

Publisher

Data Source

[Journal Article] 呼吸器合併症のスクリーニング検査について2010

Author(s)

Journal Title

Data Source

[Journal Article] 呼吸器合併症のスクリーニング検査について2010

Author(s)

Journal Title

Data Source

[Journal Article] 臨床症状-腺外症状-甲状腺病変2009

Author(s)

Journal Title

Data Source

[Journal Article] Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 禁煙を科学する「喫煙による内分泌代謝機能への影響」2008

Author(s)

Journal Title

HIRANO Fuminori 平野史倫

[Journal Article] 特集「古くて新しい胆汁酸最近の話題」胆汁酸による転写因子活性化機構2007