Hisamatsu Tadakazu 久松理一

… Alternative Names

HISAMATSU Tadakazu 久松理一

久松理一ヒサマツタダカズ

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Researcher Number	60255437
Other IDs
Affiliation (Current)	2025: 杏林大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 杏林大学, 医学部, 教授 2015 – 2023: 杏林大学, 医学部, 教授 2008 – 2014: Keio University, 医学部, 講師 2009: 医学部, 講師 2007: Keio University, School of Medicine, Instructor 2004 – 2006: 慶應義塾大学, 医学部, 助手 1998 – 2001: 東京歯科大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology / 病態科学系歯学(含放射線系歯学) / Immunology
Keywords	Principal Investigator 炎症性腸疾患 / サイトカイン / 炎症性サイトカイン / クローン病 / 潰瘍性大腸炎 / 機械学習 / ケモカイン / IFN-g / IL-23 / M-CSF … More / マクロファージ / 治療有効性 / 効果予測 / 分子標的治療薬 / 5-アミノサリチル酸製剤 / メタゲノム解析 / 腸内微生物叢 / 雌雄差 / 経時的変化 / 腸管免疫 / 腸内細菌叢 / 抗炎症作用 / 腸管微生物叢 / 5-アミノサリチル酸 / マウスモデル / 質量分析 / 遺伝性小腸潰瘍症 / CEAS / SLCO2A1 / プロスタグランジン / 小腸潰瘍 / IL-10 / エネルギー代謝 / 分化 / 酸化的リン酸化 / 解糖系 / 代謝 / サイトカイン産生 / 細胞内エネルギー代謝 / pro-inflammatory cytokine / gut flora / Crohn disease / intestinal macrophage / 腸内細菌 / 腸管マクロファージ / IgG形質細胞 / 免疫複合体 / ケモカイン受容体 / IgG産生形質細胞 / アミノインデックス / アミノインデックスR / メタボローム / アミノインデックス[○!R] / ヒスチジン / アミノ酸 / 自然免疫 / 腸管上皮細胞 / NOD2 / CARD15 / IFN inducible gene / interferon inducible gene / differential display / colitic cancer … More Except Principal Investigator 腸内細菌 / 炎症性腸疾患 / Adherence / Colonization / Heat shock protein / Oral cavity / Campylobacter rectus / Helicobacter pylori / マクロファージ / CEAS / SLCO2A1 / トランスポーター / プロスタグランジン / SLCO2A1遺伝子 / 小腸潰瘍 / 免疫学 / 下部消化管 / 下部消化管学 / Th17細胞 / 腸管外合併症 / 原発性硬化性胆管炎 / 潰瘍性大腸炎 / 歯周病原菌 / 共通抗原 / 口腔感染症 / 口腔 / 唾液 / 歯周病原細菌 / 交差反応性 / 診断 / 感染経路 / Periodonititis / Coaggregation / Cross reactivity / Periodontitis / Peridontitis / Shared antigen / サイトカイン / NK細胞 / 細胞内寄生菌 / 自然免疫 / オートファジー / クローン病 / 粘膜免疫 Less

免疫プロファイルの包括的評価による病態に基づく炎症性腸疾患の新規分類と治療有効性Principal Investigator
- Principal Investigator
  
  久松理一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyorin University
Development of therapeutic effect prediction tool for molecular-targeted drugs in inflammatory bowel disease using machine learningPrincipal Investigator
- Principal Investigator
  
  久松理一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyorin University
Investigating the anti-inflammatory mechanism of 5-ASA and exploring the new therapeutic strategy for IBD by the comprehensive analysis for the gut microbiomePrincipal Investigator
- Principal Investigator
  
  Hisamatsu Tadakazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyorin University
Functional analysis of SLCO2A1 transporter
- Principal Investigator
  
  Hayashida Mari
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyorin University
Elucidation of regulation of intestinal macrophage differentiation from intracellular energy metabolismPrincipal Investigator
- Principal Investigator
  
  HISAMATSU TADAKAZU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kyorin University
To identify the mechanism of inflammatory bowel disease by using human microbe mono-associated mouse
- Principal Investigator
  
  KANAI TAKANORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Elucidation of the pathology and treatment of refractory small intestinal ulcer disease using genetically engineered mouse and PG mass spectrometryPrincipal Investigator
- Principal Investigator
  
  HISAMATSU TADAKAZU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyorin University
Mucosal IgG plasma cell as a novel therapeutic target in the pathogenesis of ulcerative colitis .Principal Investigator
- Principal Investigator
  
  HISAMATSU Tadakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Investigation of intestinal macrophage in contribution to gut immune homeostasis and its disruption in Crohn's disease
- Principal Investigator
  
  HIBI Toshifumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Elucidation of intestinal mucosal immune system through the intracellular processing mechanisms of bacteria and its application for novel therapy of inflammatory bowel disease
- Principal Investigator
  
  INOUE Nagamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Development of a biomarker for inflammatory bowel disease by plasma amino acids profile.Principal Investigator
- Principal Investigator
  
  HISAMATSU Tadakazu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Analysis of abnormal function of immunosuppressive intestinal macrophages in Crohn diseasePrincipal Investigator
- Principal Investigator
  
  HISAMATSU Tadakazu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
腸上皮細胞におけるNOD2の細胞内局在とpathogen認識メカニズムの解明Principal Investigator
- Principal Investigator
  
  久松理一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Analysis of Hellcobacter pylori infection route from oral biological view point.
- Principal Investigator
  
  ISHIHARA Kazuyuki
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  TOKYO DENTAL COLLEGE
炎症からの発癌。潰瘍性大腸炎からの大腸癌発癌機序の分子遺伝子学的解析Principal Investigator
- Principal Investigator
  
  久松理一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Dental College

[Book] 炎症性腸疾患2012
- Author(s)
  久松理一、日比紀文
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-21249048
[Book] 潰瘍性大腸炎消化器疾患ガイドライン2011
- Author(s)
  久松理一、日比紀文
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-21249048
[Book] G.I.Research IBDと炎症性サイトカイン-Th17-2011
- Author(s)
  久松理一、日比紀文
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-21249048
[Book] 消化器BookシリーズNo.2特集:炎症性腸疾患の診断・治療2010
- Author(s)
  日比紀文、久松理一
- Total Pages
  213
- Publisher
  羊土社出版
- Data Source
  KAKENHI-PROJECT-21249048
[Book] 消化器BookシリーズNo.2特集:炎症性腸疾患の診断・治療2010
- Author(s)
  日比紀文、久松理一
- Total Pages
  340
- Publisher
  医学書院出版
- Data Source
  KAKENHI-PROJECT-21249048
[Book] Th-17細胞の機能はどこまで明らかになれたか? IBD Research vol. 2 no. 42008
- Author(s)
  久松理一, 日比紀文
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-20590749
[Book] 腸管免疫研究の最前線-腸管の恒常性維持と炎症性腸疾患におけるその破綻-Annual Review 消化器20082008
- Author(s)
  久松理一, 鎌田信彦, 日比紀文
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Book] タンパク質・アミノ酸代謝と腸管免疫の関わり合い『栄養一評価と治療』25巻1号2008
- Author(s)
  久松理一, 日比紀文
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-20590749
[Book] 腸管免疫研究の最前線-腸管の恒常性維持と炎症性腸疾患におけるその破綻-Annual Review消化器20082008
- Author(s)
  久松理一, 鎌田信彦, 日比紀文
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20590749
[Book] 特集「消化器疾患におけるアポトーシスを見直す」4)アポトーシスは炎症性腸疾患とどのようにかかわるか? 分子消化器病vol. 5 no. 22008
- Author(s)
  久松理一, 日比紀文
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-20590749
[Book] クローン病の発症と樹状細胞からのIL-23 臨床免疫、アレルギー科 49巻1号2008
- Author(s)
  鎌田信彦, 久松理一, 岡本晋, 日比紀文
- Publisher
  科学評論社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Book] 腸管免疫研究の最前線-腸管の恒常性維持と炎症性腸疾患におけるその破綻2008
- Author(s)
  久松理一, 鎌田信彦, 日比紀文
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18590700
[Book] 腸管粘膜マクロファージによる腸管ホメオスターシスとその破綻分子消化器病 vol.4 No.22007
- Author(s)
  鎌田信彦, 久松理一, 日比紀文
- Publisher
  先端医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Book] IL-10産生性抑制性腸管マクロファージの特殊性とIBD治療へのアプローチ IBD Research vol.1 no.32007
- Author(s)
  久松理一, 鎌田信彦, 日比紀文
- Publisher
  先端医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Book] 慢性大腸炎とIL-12, IL-23産生マクロファージ臨床免疫、アレルギー科 46巻4号2006
- Author(s)
  久松理一, 鎌田信彦, 日比紀文
- Publisher
  科学評論社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.2019
- Author(s)
  Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T.
- Journal Title
  
  World J Gastroenterol
  
  Volume: Apr 14;25(14): Issue: 14 Pages: 1753-1763
- DOI
  10.3748/wjg.v25.i14.1753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09394
[Journal Article] Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease.2018
- Author(s)
  Umeno J, Esaki M, Hirano A, Fuyuno Y, Ohmiya N, Yasukawa S, Hirai F, Kochi S, Kurahara K, Yanai S, Uchida K, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Nagayama M, Yamamoto H, Abukawa D, Kakuta F, Onodera K, Matsui T, Hibi T, Yao T, Kitazono T, Matsumoto T;CEAS study group.
- Journal Title
  
  J Gastroenterol
  
  Volume: Jan 8 Issue: 8 Pages: 907-915
- DOI
  10.1007/s00535-017-1426-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04811
[Journal Article] Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis2017
- Author(s)
  .Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T
- Journal Title
  
  Gastroenterology
  
  Volume: 4 Issue: 4 Pages: 935-947
- DOI
  10.1053/j.gastro.2017.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K08564, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-18K07947, KAKENHI-PROJECT-16K09326
[Journal Article] Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages.2017
- Author(s)
  Chiba S, Hisamatsu T, Suzuki H, Mori K, Kitazume MT, Shimamura K, Mizuno S, Nakamoto N, Matsuoka K, Naganuma M, Kanai T.
- Journal Title
  
  Immunol Lett.
  
  Volume: Mar;183 Pages: 17-23
- DOI
  10.1016/j.imlet.2017.01.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15296
[Journal Article] Chronic Enteropathy Associated With SLCO2A1 Gene [CEAS]-Characterisation of an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn’s Disease2017
- Author(s)
  Hosoe Naoki、Ohmiya Naoki、Yano Tomonori、Okita Yoshiki、Araki Toshimitsu、Saruta Masayuki、Ohtsuka Kazuo、CEAS Atlas Group
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 11 Issue: 10 Pages: 1277-1281
- DOI
  10.1093/ecco-jcc/jjx068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-15H04811
[Journal Article] 『非特異性多発性小腸潰瘍症/CEAS-遺伝子異常と類縁疾患』主題研究１．SLCO2A1の機能とその異常2017
- Author(s)
  久松理一，關　里和
- Journal Title
  
  胃と腸
  
  Volume: 52巻　第11号 Pages: 1453-1457
- Data Source
  KAKENHI-PROJECT-15H04811
[Journal Article] Findings of ulceration and severe stricture on MRE can predict prognosis of Crohn's disease in patients treated with anti-TNF treatment.2016
- Author(s)
  Naganuma M, Okuda S, Hisamatsu T, Matsuoka K, Mori K, Hosoe N, Nakazato Y, Ogata H, Kanai T.
- Journal Title
  
  Abdom Radiol (NY).
  
  Volume: 42(1) Issue: 1 Pages: 141-151
- DOI
  10.1007/s00261-016-0878-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K15298
[Journal Article] Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial.2016
- Author(s)
  Matsumoto T, Motoya S, Watanabe K, Hisamatsu T, Nakase H, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T
- Journal Title
  
  J Crohns Colitis.
  
  Volume: 10(11) Pages: 1259-1266
- Data Source
  KAKENHI-PROJECT-15H02534
[Journal Article] 非特異性多発性小腸潰瘍症の難病指定とSLCO2A1関連小腸症2016
- Author(s)
  小林拓, 梅野淳嗣, 久松理一, 江崎幹宏, 松井敏幸, 松本主之, 日比紀文
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 113(8) Pages: 1380-1385
- NAID
  130005253859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04811
[Journal Article] 特集/小腸潰瘍発症メカニズムはどこまで明らかになったか非特異性多発性小腸潰瘍症（CEAS）の発症メカニズム2016
- Author(s)
  梅野淳嗣，江崎幹宏，久松理一，河内修司，蔵原晃一，安川重義，平井郁仁，松井敏幸，八尾恒良，北園孝成，松本主之
- Journal Title
  
  GI Research 先端医学社
  
  Volume: 第24巻5号 Pages: 20-27
- Data Source
  KAKENHI-PROJECT-15H04811
[Journal Article] Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages.2016
- Author(s)
  Suzuki H, Hisamatsu T, Chiba S, Mori K, Kitazume MT, Shimamura K, Nakamoto N, Matsuoka K, Ebinuma H, Naganuma M, Kanai T.
- Journal Title
  
  Immunol Lett.
  
  Volume: Aug;176 Pages: 18-27
- DOI
  10.1016/j.imlet.2016.05.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15296
[Journal Article] 特集/小腸潰瘍発症メカニズムはどこまで明らかになったか SLCO2A1の機能とプロスタグランジン関連腸症2016
- Author(s)
  久松理一
- Journal Title
  
  GI Research 先端医学社
  
  Volume: 第24巻5号 Pages: 28-33
- Data Source
  KAKENHI-PROJECT-15H04811
[Journal Article] Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study.2016
- Author(s)
  Sugimoto S, Naganuma M, Kiyohara H, Arai M, Ono K, Mori K, Saigusa K, Nanki K, Takeshita K, Takeshita T, Mutaguchi M, Mizuno S, Ogata H, Iwao Y, Kanai T
- Journal Title
  
  Digestion
  
  Volume: 93 Issue: 3 Pages: 193-201
- DOI
  10.1159/000444217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K15298
[Journal Article] A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter.2015
- Author(s)
  Umeno J, Hisamatsu T, Esaki M, Atsushi Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T.
- Journal Title
  
  PLoS Genetics
  
  Volume: Nov 5;11(11): Issue: 11 Pages: 1-15
- DOI
  10.1371/journal.pgen.1005581
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04811, KAKENHI-PROJECT-25460953, KAKENHI-PROJECT-26860524
[Journal Article] Computer-Aided Prediction of Long-Term Prognosis of Patients with Ulcerative Colitis after Cytoapheresis Therapy2015
- Author(s)
  7.Takayama T, Okamoto S, Hisamatsu T, Naganuma M, Matsuoka K, Mizuno S, Bessho R, Hibi T, Kanai T
- Journal Title
  
  PLoS One
  
  Volume: 10(6) Issue: 6 Pages: e0131197-e0131197
- DOI
  10.1371/journal.pone.0131197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Crohn's Disease in which the Patient Developed Aortitis during Treatment with Adalimumab2015
- Author(s)
  6.Kiyohara H, Hisamatsu T, Matsuoka K, Naganuma M, Kameda H, Seta N, Takeuchi T, Kanai T
- Journal Title
  
  Intern. Med.
  
  Volume: 54 Issue: 14 Pages: 1725-1732
- DOI
  10.2169/internalmedicine.54.3853
- NAID
  130005088259
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Inflammatory bowel disease and bone decreased bone mineral density2015
- Author(s)
  Hisamatsu T, Wada Y, Kanai T
- Journal Title
  
  Clin Calcium
  
  Volume: 25(11) Pages: 1639-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02534
[Journal Article] Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.2015
- Author(s)
  Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 10 Pages: 1-10
- DOI
  10.1371/journal.pone.0140716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15H02534
[Journal Article] Fecal Microbiota Transplantation for Gastrointestinal Diseases2014
- Author(s)
  Matsuoka K, Kanai T.
- Journal Title
  
  The Keio Journal of Medicine
  
  Volume: 63 Issue: 4 Pages: 69-74
- DOI
  10.2302/kjm.2014-0006-RE
- NAID
  130004713429
- ISSN
  0022-9717, 1880-1293
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390190, KAKENHI-PROJECT-24590951
[Journal Article] TGR5 signaling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn’s disease.2013
- Author(s)
  Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, KoganeiK, Sugita A, Kanai T and Hibi T
- Journal Title
  
  Immunology
  
  Volume: 139(1) Pages: 19-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Immune aspects of the pathogenesis of inflammatory bowel disease.2013
- Author(s)
  Hisamatsu T, Kanai T, Yohei Mikami, Yoneno K, Matsuoka K, Hibi T
- Journal Title
  
  Pharmacol Ther.
  
  Volume: 137(3) Pages: 283-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages.2013
- Author(s)
  Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, and Hibi T.
- Journal Title
  
  Hepatology Research
  
  Volume: [Epub ahead of print]
- NAID
  10031194568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] 炎症性腸疾患の病態解明と治療の進歩2013
- Author(s)
  久松理一，日比紀文
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 102巻, 臨時増刊号
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice.2013
- Author(s)
  Handa T, Kanai T, Sato T, Mikami Y, Sujino T, Hayashi A, Mizuno S, Matsumoto A, Hisamatsu T, Hibi T.
- Journal Title
  
  Immunol Lett.
  
  Volume: 150(1-2) Pages: 123-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation2013
- Author(s)
  Uo M
- Journal Title
  
  Gut
  
  Volume: in press Issue: 12 Pages: 1734-44
- DOI
  10.1136/gutjnl-2012-303063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24590951, KAKENHI-PROJECT-24659375
[Journal Article] Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway2012
- Author(s)
  Ichikawa R, Hisamatsu T, Hibi T, et al.
- Journal Title
  
  Immunology
  
  Volume: 136(2) Pages: 153-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease.2012
- Author(s)
  Hisamatsu T, Okamoto S, Hashimoto M, Muramatsu T, Andou A, Uo M, Kitazume MT, Matsuoka K, Yajima T, Inoue N, Kanai T, Ogata H, Iwao Y, Yamakado M, Sakai R, Ono N, Ando T, Suzuki M, Hibi T.
- Journal Title
  
  PLoS One.
  
  Volume: 7(1):
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells2012
- Author(s)
  Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A
- Journal Title
  
  J Exp Med.
  
  Volume: 209(13) Pages: 2383-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] -Is the dendritic cell a missing piece in the pathogenesis model of post-infectious irritable bowel syndrome?- Editorial for “Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome.”2012
- Author(s)
  Hisamatsu T, Hibi T
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 27(5) Pages: 847-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.2012
- Author(s)
  Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
- Journal Title
  
  Gastroenterology.
  
  Volume: 143(5) Pages: 1288-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.2012
- Author(s)
  Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, Higuchi H, Matsuoka K, Watanabe M, Itoh H, Kanai T, Hisamatsu T, Hibi T.
- Journal Title
  
  Immunology.
  
  Volume: 136(2) Pages: 153-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590951
[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.2011
- Author(s)
  Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: Feb24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells2011
- Author(s)
  Sujino T, Kanai T, Hisamatsu T, Hibi T, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 141(3) Pages: 1014-1023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity2011
- Author(s)
  Kobayashi T, Hisamatsu T, Hibi T, Rothman PB, Kashiwada M
- Journal Title
  
  J Immunol
  
  Volume: 186(8) Pages: 4649-4655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages Clin Exp Immunol2011
- Author(s)
  Naruse H, Hisamatsu T, Kanai T, Hibi T, et al.
- Volume
  164(1)
- Pages
  137-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Rothman PB, Kashiwada M, Plevy SE.NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity2011
- Author(s)
  Kobayashi T, Hisamatsu T, Hibi T, et al, 他8名、11番目
- Journal Title
  
  J Immunol
  
  Volume: 186(8) Pages: 4649-4655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.2011
- Author(s)
  Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
- Journal Title
  
  Clin Exp Immunol. 164(1)
  
  Pages: 137-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] ヒト腸管自然免疫担当細胞による恒常性維持と炎症性腸疾患におけるその破綻2011
- Author(s)
  久松理一、鎌田信彦、日比紀文
- Journal Title
  
  細胞工学(監修清野宏)(秀潤社)
  
  Volume: Vol.30 No.4 Pages: 366-370
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 特集:小腸疾患:診断と治療の進歩II.診療の進歩6.Crohn病2011
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 第100巻第1号 Pages: 85-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 総説『クローン病の長期予後について考える』2011
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 108巻3号 Pages: 373-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 炎症性腸疾患におけるアミノ酸補給の意義2011
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  日本消化吸収学会雑誌
  
  Volume: 33(3) Pages: 352-361
- NAID
  10029066191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages. 2011 Feb 24.2011
- Author(s)
  Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: Feb 24.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages2011
- Author(s)
  Naruse H, Hisamatsu T, Kanai T, Hibi T, et al, 他7名、11番目
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 164(1) Pages: 137-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease2011
- Author(s)
  Miyoshi J, Hisamatsu T, Kanai T, Hibi T, et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 46(9) Pages: 1056-1063
- NAID
  10029706720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 炎症性腸疾患におけるアミノ酸補給の意義2011
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  日本消化吸収学会雑誌総説
  
  Volume: (in press)
- NAID
  10029066191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] ヒト腸管自然免疫担当細胞による恒常性維持と炎症性腸疾患におけるその破綻2011
- Author(s)
  久松理一、鎌田信彦、日比紀文
- Journal Title
  
  細胞工学監修清野宏秀潤社
  
  Volume: Vol.30 No.4 Pages: 366-370
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 特集:小腸疾患:診断と治療の進歩II.診療の進歩62011
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  Crohn病日本内科学会雑誌
  
  Volume: 第100巻第1号 Pages: 85-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] アミノ酸と免疫2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  Functinal Food
  
  Volume: 第11号Vol.4 No.1 Pages: 16-22
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
- Author(s)
  Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
- Journal Title
  
  Gastroenterology. 139(3)
  
  Pages: 882-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] 特集:生体防御と自然免疫-最近の知見Workshop実臨床のトピックスIBD発症進展における自然免疫の役割2010
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  侵襲と免疫メジカルビュー社
  
  Volume: Vol.19 No.2 Pages: 39-42
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: Apr;16(4) Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease2010
- Author(s)
  Kamada N, Hisamatsu T, Kanai T, Hibi T., et al.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 16(4) Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease2010
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 16(4)
  
  Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] 特集:生体防御と自然免疫-最近の知見Workshop実臨床のトピックスIBD発症進展における自然免疫の役割2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  侵襲と免疫
  
  Volume: Vol.19 No.2 Pages: 39-42
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Imbalance of NKp44 (+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
- Author(s)
  Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
- Journal Title
  
  Gastroenterology
  
  Volume: Sep;139(3) Pages: 882-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  IBD Research(先端医学社)
  
  Volume: 12月号vol.4, no.4 Pages: 38-42
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset.2010
- Author(s)
  Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
- Journal Title
  
  J Immunol. 184(5)
  
  Pages: 2671-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] 消化器疾患と樹状細胞病態の解明と治療法の開発クローン病におけるCD14+腸管マクロファージの抗原提示能について2010
- Author(s)
  久松理一、井上詠, 他
- Journal Title
  
  消化器と免疫
  
  Volume: 46 Pages: 36-38
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] アミノ酸と免疫Functinal Food2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  特集『免疫と機能性食品』2010第11号 Vol.4 No.1
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Imbalance of NKp44(+) NKp46(-) and NKp44(-) NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease2010
- Author(s)
  Takayama T, Hisamatsu T, Kanai T, Hibi T., et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 139(3) Pages: 882-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.2010
- Author(s)
  Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T
- Journal Title
  
  J Immunol
  
  Volume: 184(5) Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 16(4)
  
  Pages: 568-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Competitio between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis2010
- Author(s)
  Mikami Y, Kanai T, Hisamatsu T, Hibi T., et al.
- Journal Title
  
  Eur J Immunol
  
  Volume: 40(9) Pages: 2409-2422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
- Author(s)
  Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T
- Journal Title
  
  Eur J Immunol 40(9)
  
  Pages: 2409-2422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset.2010
- Author(s)
  Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T
- Journal Title
  
  J Immunol.
  
  Volume: Mar 1;184(5) Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断IBD Research先端医学社2010
- Author(s)
  久松理一、日比紀文
- Volume
  12月号vol.4 no.4
- Pages
  38-42
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
- Author(s)
  Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inone N, Ogata H, Hibi T.
- Journal Title
  
  Eur J Immunol.
  
  Volume: Sep;40(9) Pages: 2409-2422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset2010
- Author(s)
  Takada Y, Hisamatsu T, Kanai T, Hibi T., et al.
- Journal Title
  
  J Immunol
  
  Volume: 184(5) Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset2010
- Author(s)
  Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
- Journal Title
  
  J Immunol 184(5):
  
  Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
- Author(s)
  Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
- Journal Title
  
  Gastroenterology
  
  Volume: Sep;139(3) Pages: 882-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2010
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  炎症性腸疾患と腸管局所免疫 Annual Review 消化器(中外医学社)
  
  Pages: 8-15
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
- Author(s)
  Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T.
- Journal Title
  
  Eur J Immunol.
  
  Volume: Sep;40(9) Pages: 2409-2422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 16(4) Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] アミノ酸と免疫2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  Functinal Food
  
  Volume: 第11号Vol.4, No.1 Pages: 16-22
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2010
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  炎症性腸疾患と腸管局所免疫 Annual Review 消化器 8-15(中外医学社)
  
  Pages: 8-15
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  IBD Research vol.4 no.4
  
  Pages: 308-313
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断2010
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  IBD Research先端医学社
  
  Volume: 12月号vol.4 no.4 Pages: 38-42
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease2010
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 16(4)
  
  Pages: 568-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset2010
- Author(s)
  Takada Y, Hisamatsu T, et al
- Journal Title
  
  J Immunol 184
  
  Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset2010
- Author(s)
  Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T
- Journal Title
  
  J Immunol 184(5)
  
  Pages: 2671-2676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells2009
- Author(s)
  Wada Y, Hisamatsu T, Kamada N, Okamoto S, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 15(10)
  
  Pages: 1548-1556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen presenting ability.2009
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume M, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
- Journal Title
  
  J Immunol. 183(3)
  
  Pages: 1724-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells2009
- Author(s)
  Wada Y, Hisamatsu T, Kamada N, Okamoto S, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 15(10)
  
  Pages: 1548-1556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  齊藤理子, 久松理一, 日比紀文
- Journal Title
  
  マクロファージからのIL-23産生と大腸炎、共生菌の関与臨床免疫・アレルギー科 52巻4号(科学評論社)
  
  Pages: 384-388
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  久松理一
- Journal Title
  
  日本人のヒット作品ヒスチジンの経口投与がマクロファージからの炎症性サイトカインを抑えることでマウス腸炎を抑制する分子消化器病 vol.6, no.2(先端医学社)
  
  Pages: 83-85
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] クローン病における腸管マクロファージの腸内細菌認識異常IL-23を中心とした慢性炎症サイクル2009
- Author(s)
  久松理一、井上詠, 他
- Journal Title
  
  消化器と免疫 45
  
  Pages: 52-54
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article]2009
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  腸管マクロファージとIBD IBD Research vol.3 no.3(先端医学者)
  
  Pages: 183-187
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article]2009
- Author(s)
  高山哲朗, 久松理一, 日比紀文
- Journal Title
  
  【消化器疾患の分子医学基礎医学から臨床へ】腸管免疫の分子機構臨床消化器内科 24巻2号(日本メディカルセンター)
  
  Pages: 217-223
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  腸管マクロファージとIBD IBD Research vol.3 no.3(先端医学社)
  
  Pages: 183-187
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  ATG16L1とTNFSF15G.I Research vol.17 no.6(先端医学社)
  
  Pages: 548-550
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages2009
- Author(s)
  Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
- Journal Title
  
  Gastroenterology 136(2)
  
  Pages: 564-574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article]2009
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  Th-17細胞の機能はどこまで明らかになれたか?IBD Researoh vol.2 no.4(先端医学社)
  
  Pages: 308-313
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  高山哲朗, 久松理一
- Journal Title
  
  【消化器疾患の分子医学基礎医学から臨床へ】腸管免疫の分子機構臨床消化器内科24巻2号(日本メディカルセンター)
  
  Pages: 217-223
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article]2009
- Author(s)
  齊藤理子, 久松理一, 日比紀文
- Journal Title
  
  マクロファージからのIL-23産生と大腸炎、共生菌の関与臨床免疫・アレルギー科52巻4号(科学評論社)
  
  Pages: 384-388
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages.2009
- Author(s)
  Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
- Journal Title
  
  Gastroenterology. 136(2)
  
  Pages: 564-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Homeostatic(IL-7)and effector(IL-17)cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease2009
- Author(s)
  Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.
- Journal Title
  
  Curr Opin Gastroenterol Jul;25(4)
  
  Pages: 306-313
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Pathogen-Specific Antibody : Cause or Effect?2009
- Author(s)
  Hisamatsu T, Hibi T
- Journal Title
  
  Gastroenterology Nov;137(5)
  
  Pages: 1570-1573
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages.2009
- Author(s)
  Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
- Journal Title
  
  Gastroenterology 136(2)
  
  Pages: 564-574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability2009
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume MT, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T
- Journal Title
  
  J Immunol. 183(3)
  
  Pages: 1724-1731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability2009
- Author(s)
  Kamada N, Hisamatsu T, et al
- Journal Title
  
  J Immunol 183
  
  Pages: 1724-1731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability2009
- Author(s)
  Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume MT, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T
- Journal Title
  
  J Immunol. 183(3):
  
  Pages: 1724-1731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages2009
- Author(s)
  Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
- Journal Title
  
  Gastroenterology 136(2):
  
  Pages: 564-574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article]2009
- Author(s)
  久松理一, 日比紀文
- Journal Title
  
  Th-17細胞の機能はどこまで明らかになれたか?IBD Research vol.2 no.4(先端医学社)
  
  Pages: 308-313
- Data Source
  KAKENHI-PROJECT-21249048
[Journal Article] Retinoic acid contributes to the gut-specific immune tolerance via induction of IL-12-hypoproducing tolerogenic dendritic cells.2009
- Author(s)
  Wada Y, Hisamatsu T, Kamada N, Okammoto S, Hibi T
- Journal Title
  
  Inflamm Bowel Dis. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Non-pathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells.2008
- Author(s)
  Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T
- Journal Title
  
  Infect Immun 76(1)
  
  Pages: 214-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogen esis of Crohn's disease via IL-23/IFN-g axis2008
- Author(s)
  Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume M.T, Sugita A, Koganei K, Akagawa K.S, and Tosbifumi Hibi T.
- Journal Title
  
  J.Clip Invest Vol.118
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/ IFN-gamma axis2008
- Author(s)
  Kamada N, Hisamatsu T, et.al.
- Journal Title
  
  J Clin Invest 118
  
  Pages: 2269-2280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-g axis2008
- Author(s)
  Kamada, N., Hisamatsu, T., Okamoto, S., Chinen, H., Kobayashi, T., Sato, T., Sakuraba, A., Kitazume, M. T, Sugita, A., Koganei, K., Akagawa, KS., Toshifumi, Hibi, T
- Journal Title
  
  J. Clin Invest 118(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal transd uction in intestinal epithelial cells2008
- Author(s)
  Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T
- Journal Title
  
  Infect Immun Jan;76(1)
  
  Pages: 214-220
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-g axis2008
- Author(s)
  Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume M. T, Sugita A, Koganei K, Akagawa K. S, Toshifumi Hibi T.
- Journal Title
  
  J. Clin Invest 118(6)
  
  Pages: 2269-2280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] IL-23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.2008
- Author(s)
  Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe KI, Hibi T
- Journal Title
  
  Gut 57(12)
  
  Pages: 1682-1689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Innate immunity in inflammatory bowel disease : state of the art.2008
- Author(s)
  Hisamatsu T, Ogata H, Hibi T
- Journal Title
  
  Curr Opin Gastroenterol. 24(4)
  
  Pages: 448-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal trans duction in intestinal epithelial cells.2008
- Author(s)
  Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T.
- Journal Title
  
  Infect Immun. 76(1)
  
  Pages: 214-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Innate Immunity in IBD - State of the Art2008
- Author(s)
  Hisamatsu, T, Ogata, H., Toshifumi Hibi T
- Journal Title
  
  Current Opinion in Gastroenterology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice.2008
- Author(s)
  Nanno M, Kanari Y, Naito T, Inoue N, Hisamatsu T, Chinen H, Sugimoto K, Shimomura Y, Yamagishi H, Shiohara T, Ueha S, Matsushima K, Suematsu M, Mizoguchi A, Hibi T, Bhan A K, Ishikawa H.
- Journal Title
  
  Gastroenterology 134(2)
  
  Pages: 481-490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-g axis2008
- Author(s)
  Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume M. T, Sugita A, Koganei K, Akagawa K. S, Toshifumi Hibi T.
- Journal Title
  
  J. Clin Invest 118(6)
  
  Pages: 2269-2280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Innate Immunity in IBD-State of the Art2008
- Author(s)
  Hisamatsu T, Ogata H and Toshifumi Hibi T.
- Journal Title
  
  Current Opinion in Gastroenterology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice.2008
- Author(s)
  Nanno M, Kanari Y, Naito T, Inoue N, Hisamatsu T, Chinen H, Sugimoto K, Shimomura Y, Yamagishi H, Shiohara T, Ueha S, Matsushima K, Suematsu M, Mizoguchi A, Hibi T, Bhan AK, Ishikawa
- Journal Title
  
  Gastroenterology 134(2)
  
  Pages: 481-490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice.2008
- Author(s)
  Ichikawa H, Okamoto S, Kamada N, Nagamoto H, Kitazume MT, Kobayashi T, Chinen H, Hisamatsu T, Hibi T.
- Journal Title
  
  Inflamm Bowel Dis. 14(11)
  
  Pages: 1483-1490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Journal Article] Nonpathogenic Escherichia coli strain Nissle 1917 inhbits signal transduction in intestinal epithelial cells2008
- Author(s)
  Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsucbimoto K, Ogata H, Hibi T
- Journal Title
  
  Infect Immun. Jan;76(1)
  
  Pages: 214-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Nonpathogenic Escherichia coli strain Nissie 1917 inhibits signal transduction in intestinal epithelial cells.2008
- Author(s)
  Kamada, N., Maeda, K., Inoue, N., Hisamatsu, T., Okamoto, S., Hong, KS, Yamada, T, Watanabe, N., Tsuchimoto, K., Ogata, H., Hibi T
- Journal Title
  
  Infect Immun 76(1)
  
  Pages: 214-220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells.2007
- Author(s)
  Chinen, H., Matsuoka, K., Sato, T., Kamada, N., Okamoto, S., Hisamatsu, T., Kobayashi, T., Hasegawa, H., Sugita, A., Kinjo, F., Fujita, J., Hibi, T
- Journal Title
  
  Gastroenterology 133(2)
  
  Pages: 559-573
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes2007
- Author(s)
  Kobayashi T, Okamoto S, Iwakami Y, Nakazawa A, Hisamatsu T, Chinen H, Kamada N, Imai T, Goto H, Hibi T
- Journal Title
  
  Inflamm Bowel Dis. July;13(7)
  
  Pages: 837-846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes.2007
- Author(s)
  Kobayashi, T., Okamoto, S., Iwakami, Y., Nakazawa, A., Hisamatsu, T., Chinen, H., Kamada, N., Imai, T., Goto, H., Hibi, T
- Journal Title
  
  Inflamm Bowel Dis 13(7)
  
  Pages: 837-846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Psychological aspects of inflammatory bowel disease.2007
- Author(s)
  Hisamatsu T, Inoue N, Yajima T, Izumiya M, Ichikawa H, Hibi T
- Journal Title
  
  J Gastroenterol Jan;42
- NAID
  10018539843
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exclusive increase of CX3CR1(+)CD28(-)CD4(+) T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes2007
- Author(s)
  Kobayashi T, Hisamatsu T, Hibi T, etal
- Journal Title
  
  Inflamm Bowel Dis Feb 6
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes2007
- Author(s)
  Kobayashi T, Okamoto S, Iwakami Y, Nakazawa A, Hisamatsu T, Chinen H, Kamada N, Imai T, Goto H, Hibi T
- Journal Title
  
  Inflamm Bowel Dis Jul;13(7)
  
  Pages: 837-846
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells2007
- Author(s)
  Chinen H, Matsuoka K, Sato T, Kamada N, Okamoto S, Hisamatsu T, Kobayashi T, Hasegawa H, Sugita A, Kinjo F, Fujita J, Hibi T
- Journal Title
  
  Gastroenterology Aug;133(2)
  
  Pages: 559-573
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis2006
- Author(s)
  Morohoshi Y, Hisamatsu T, Hibi T, etal
- Journal Title
  
  J Gastroenterol Apr;41(4)
  
  Pages: 318-24
- NAID
  10018141558
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Cytomegalovirus is frequently reactivated and disappears without a antiviral agents in ulcerative colitis patients.2006
- Author(s)
  Matsuoka K, Hisamatsu T, Hibi T, etal
- Journal Title
  
  Am J Gastroenterol Feb;102(2)
  
  Pages: 331-7
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] Centaurin betal down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.2006
- Author(s)
  Yamamoto-Furusho JK, Barnich N, Xavier R, Hisamatsu T, Podolsky DK
- Journal Title
  
  J Biol Chem Nov24;281(47)
  
  Pages: 36060-70
- Data Source
  KAKENHI-PROJECT-18590700
[Journal Article] 炎症性腸疾患におけるアミノ酸補給の意義
- Author(s)
  久松理一、日比紀文
- Journal Title
  
  日本消化吸収学会雑誌
  
  Volume: (総説 in press)
- NAID
  10029066191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 5-アミノサリチル酸の抗炎症作用機序における腸管微生物叢の関与2022
- Author(s)
  三好潤，和田晴香，久松理一
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K08380
[Presentation] 5-アミノサリチル酸の抗炎症作用における腸管微生物叢の関与2021
- Author(s)
  和田晴香，三好潤，黒沼智，日比則孝，西成田悠，小栗典明，松浦稔, 竹内修，小林拓，秋元義弘，日比紀文，久松理一
- Organizer
  第49回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08380
[Presentation] 難治性小腸疾患の診断と治療（基調講演）2019
- Author(s)
  久松理一
- Organizer
  第57回日本小腸学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09394
[Presentation] Identification ofa novel disease entity, chronic enteropathy associated with SLCO2A1 (CEAS)2017
- Author(s)
  Hisamatsu T, Umeno J, Matsumoto T.
- Organizer
  The 10th International Gastointestinal Consensus Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] Identification of a novel disease entity, chronic enteropathy associated with SLCO2A1 (CEAS)2017
- Author(s)
  Hisamatsu T, Umeno J, Matsumoto T
- Organizer
  The 10th International Gastointestinal Consensus Symposium
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2017-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] ヒト抑制性マクロファージにおいて、LPS刺激によるIL-6産生には嫌気的解糖系が利用されている2016
- Author(s)
  千葉明子、久松理一、森　清人、北爪美奈、島村克好、水野慎大、中本伸宏、松岡克善、海老沼浩利、長沼　誠、金井隆典
- Organizer
  第70回日本栄養・食糧学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K15296
[Presentation] 特別講演　非特異性多発性小腸潰瘍症の原因遺伝子同定から学んだこと　若手消化器内科Dr.へのメッセージ2016
- Author(s)
  久松理一
- Organizer
  日本消化器病学会関東支部　第341回例会
- Place of Presentation
  東京　海運クラブ
- Year and Date
  2016-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages2016
- Author(s)
  千葉明子、鈴木宏明、久松理一、中本伸宏、金井隆典
- Organizer
  第45回日本免疫学会
- Place of Presentation
  那覇
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K15296
[Presentation] SLCO2A1発現解析を用いた非特異性多発性小腸潰瘍症の診断と病態解明へアプローチ2016
- Author(s)
  久松理一，島村克好，細江直樹，杉浦悠毅，高橋信一，金井隆典
- Organizer
  第12回日本消化管学会総会学術集会
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2016-02-26
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] ワークショップ4「小腸疾患：病態解明への新たな知見」2015
- Author(s)
  久松理一、細江直樹、金井隆典
- Organizer
  第101回日本消化器病学会
- Place of Presentation
  仙台国際センター宮城県仙台市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 非特異性多発性小腸潰瘍症の診断における内視鏡下生検の意味ワークショップ7　希少難治性消化管疾患における内視鏡の役割2015
- Author(s)
  久松理一，細江直樹，金井隆典
- Organizer
  第89回日本消化器内視鏡病学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] 質量分析法を用いたNSAIDs起因性小腸潰瘍の小腸粘膜PG代謝物の網羅的解析による病態解明と今後の展望2015
- Author(s)
  久松理一，島村克好，金井隆典，高橋信一，杉浦悠毅
- Organizer
  第53回小腸研究会
- Place of Presentation
  盛岡
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] SLOCO2A1変異によるPG輸送障害と非特異性多発性小腸潰瘍症2015
- Author(s)
  久松理一，細江直樹，金井隆典
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] 非特異性多発性小腸潰瘍症の診断における内視鏡下生検の意味2015
- Author(s)
  久松理一、細江直樹、金井隆典
- Organizer
  第89回日本消化器内視鏡学会
- Place of Presentation
  名古屋国際会議場愛知県名古屋市
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-15H02534
[Presentation] 低用量アスピリン起因性小腸粘膜障害に対する腸溶性カプセルに充填したエカベナトリウムの効果についての検討．健常人を対象とし，カプセル内視鏡を用いた二重盲検，クロスオーバー，パイロット試験2015
- Author(s)
  林田真理，久松理一，高橋信一
- Organizer
  JDDW 2015
- Place of Presentation
  東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H04811
[Presentation] Glycolysis regulates macrophage differentiation into IL-10 producing phenotype2015
- Author(s)
  H. Suzuki, T. Hisamatsu, M. Naganuma, H. Ebinuma, N. Nakamoto, K. Mori, M. Kitazume, K. Shimamura, S. Chiba, T. Kanai
- Organizer
  IMMUNOLOGY 2015, the American Association of Immunologist
- Place of Presentation
  ニューオーリンズ、米国
- Year and Date
  2015-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15296
[Presentation] 解糖系によるIL-10産生型抑制性マクロファージの分化制御2015
- Author(s)
  久松理一，鈴木宏明、千葉明子、森清人、島村克好、徳武美奈、金井隆典
- Organizer
  第52回消化器免疫学会総会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15K15296
[Presentation] Mucosal IgG+CXCR4+ plasma cells contribute to the pathogenesis of ulcerative colitis through FcR-mediated activation of CD14+ macrophages.2012
- Author(s)
  Hisamatsu T, Uo M, Hibi T.
- Organizer
  The 3rd International Forum the 98th General Meeting of JSGE
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-24590951
[Presentation] Intestinal CXCR4+IgG+ immature plasma cells contribute to the pathogenesis of ulcerative colitis through IgG-immune complex-FcR signaling2012
- Author(s)
  Hisamatsu T, Uo M, Miyoshi J, Yoneno K, Matsuoka K, Kanai T, Hibi T.
- Organizer
  The 14th Meeting of International Conference on Ulcer Research
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24590951
[Presentation] 難治性潰瘍性大腸炎に対するタクロリムス経口投与の治療効果と限界2011
- Author(s)
  久松理一
- Organizer
  JDDW2011
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] Intestinal CXCR4+IgG+Immature Plasma Cells Contribute to the Pathogenesis of Ulcerative Colitis through IgG-Immune Complex-FcgR Signaling2011
- Author(s)
  Tadakazu Hisamatsu
- Organizer
  The 15th ICMI
- Place of Presentation
  Paris France
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] Intestinal CXCR4+IgG+ Immature Plasma Cells Contribute to the Pathogenesis of Ulcerative Colitis through IgG-Immune Complex-FcgR Signaling2011
- Author(s)
  Tadakazu Hisamatsu
- Organizer
  The 15th ICMI
- Place of Presentation
  Paris France
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] 難治性潰瘍性大腸炎に対するタクロリムス経口投与の治療効果と限界2011
- Author(s)
  久松理一
- Organizer
  JDDW2011
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] 炎症性腸疾患をアミノ酸代謝から考える2010
- Author(s)
  久松理一、日比紀文
- Organizer
  第8回日本機能性食品医用学会総会シンポジウムI免疫と機能性食品
- Place of Presentation
  大津ピアザ淡海
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて-2010
- Author(s)
  久松理一
- Organizer
  第7回肝・消化器代謝栄養研究会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 腸管マクロファージからみたクローン病のサイトカインネットワーク異常2010
- Author(s)
  久松理一、鎌田信彦、高山哲朗、齋藤理子、米野和明、松岡克善、岡本晋、井上詠、緒方晴彦、金井隆典、日比紀文
- Organizer
  第47回日本消化器免疫学会総会、シンポジウム
- Place of Presentation
  滋賀
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] 血漿アミノ酸プロファイルを用いた炎症性腸疾患の診断・活動性モニタリング2010
- Author(s)
  久松理一、井上詠、松岡克善、斉藤理子、筋野智久、米野和明、三好潤、三上洋平、岩男泰、緒方晴彦、金井隆典、日比紀文、安藤朗、藤山佳秀、内山和彦、高木智久、内藤裕二、吉川敏一
- Organizer
  難治性腸管障害調査研究班
- Place of Presentation
  東京
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて-2010
- Author(s)
  久松理一
- Organizer
  第7回肝・消化器代謝栄養研究会
- Place of Presentation
  大阪
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 腸管マクロファージからみたクローン病のサイトカインネットワーク異常2010
- Author(s)
  久松理一、井上詠, 他
- Organizer
  第47回日本消化器免疫学会総会
- Place of Presentation
  大津
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて-2010
- Author(s)
  久松理一
- Organizer
  第7回肝・消化器代謝栄養研究会
- Place of Presentation
  大阪
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて-2010
- Author(s)
  久松理一
- Organizer
  第7回肝・消化器代謝栄養研究会
- Place of Presentation
  大阪
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] 炎症性腸疾患をアミノ酸代謝から考える2010
- Author(s)
  久松理一、目比紀文
- Organizer
  第8回日本機能性食品医用学会総会シンポジウムI 免疫と機能性食品
- Place of Presentation
  大津ピアザ淡海
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 血漿アミノ酸プロファイルを用いた炎症性腸疾患の診断・活動性モニタリング2010
- Author(s)
  久松理一、井上詠、松岡克善、斉藤理子、筋野智久、米野和明、三好潤、三上洋平、岩男泰、緒方晴彦、金井隆典、日比紀文、安藤朗、藤山佳秀、内山和彦、高木智久、内藤裕二、吉川敏一
- Organizer
  難治性腸管障害調査研究班
- Place of Presentation
  東京
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-21249048
[Presentation] 胆汁酸はTGR5受容体を介してIL-12低産生型樹状細胞に分化誘導する/Bile acids generate IL-12 hypoproducingDCs via Tgr5 signaling pathway2009
- Author(s)
  Saito R, Hisamatsu T, Takayama T, Kamada N, Ando S, Inoue N, Okamoto S, Kanai T, Hibi T
- Organizer
  第39回日本免疫学会総会・学術集会、ワークショップ
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] Bile acids contribute to the differentiation into anti-inflammatory DCs via Tgr5 and cAMP pathway2009
- Author(s)
  Saito R, Hisamatsu T, Takayama T, Kamada N, Wada Y, Okamoto S, Hibi T
- Organizer
  the 110th Annual Meeting of the AGA Institute
- Place of Presentation
  Chicago
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 炎症性腸疾患(IBD)における血漿アミノ酸プロファイルを用いた臨床マーカー(アミノインデックス)の確立2009
- Author(s)
  高山哲朗, 久松理一, 岡本晋, 高田康裕, 小林拓, 矢島知治, 長沼誠, 緒方晴彦, 岩男泰, 日比紀文
- Organizer
  第106回日本内科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] CD4+Tlymphocytes with high CD26 surface expression are involved in the pathogenesis of inflammatory bowel disease2009
- Author(s)
  Inoue N, Hisamatsu T, Takayama T, Kamada N, Okamoto S, Yamada T, Hosono O, Morimoto C, Hibi T
- Organizer
  16th United European Gastroenterology Week
- Place of Presentation
  Austria
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] アミノ酸が直接炎症を抑える2009
- Author(s)
  久松理一
- Organizer
  エレンタール講演会
- Place of Presentation
  大阪
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] アミノ酸が直接炎症を抑える2009
- Author(s)
  久松理一
- Organizer
  エレンタール講演会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] IL-10KOマウスにおけるマクロファージからのIL-12過剰産生機序の解明2009
- Author(s)
  成瀬浩史、久松理一、鎌田信彦、岡本晋、井上詠、金井隆典、日比紀文
- Organizer
  第46回日本消化器免疫学会、一般演題
- Place of Presentation
  愛媛
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] ワークショップ1.「ヒト免疫病におけるTh17細胞とTreg細胞」ヒト免疫病における Th17細胞とTreg細胞ヒト炎症性腸疾患において重要なのはTh1かTh17か?2009
- Author(s)
  久松理一, 日比紀文
- Organizer
  日本臨床免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] INTESTINAL MACROPHAGES AND NK CELLS PLAY A CRUCIAL ROLE FOR THE PATHOGENESIS OF CROHN'S DISEASE2009
- Author(s)
  久松理一, 日比紀文
- Organizer
  Industry Symposium, the 9th World Congress on Inflammation
- Place of Presentation
  Tokyo
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病におけるCD14+腸管マクロファージの抗原提示能について2009
- Author(s)
  久松理一、鎌田信彦、本田治樹、北爪美奈、井上詠、岡本晋、金井隆典、日比紀文
- Organizer
  第46回日本消化器免疫学会、シンポジウム
- Place of Presentation
  愛媛
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] CD4+ T Lymphocytes with High CD26 Surface Expression are Involved in the Pathogenesis of inflammatory Bowel Disease2009
- Author(s)
  Inoue N, Hisamatsu T, Takayama T, Kamada N, Hibi T
- Organizer
  14th International Congress of Mucosal Immunology
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] TL-1A and IL-23 from CD14+ macrophages synergistically enhanced production of IL-17 and IFN-γ by lamina propria CD4 memory T cells in Crohn's disease2009
- Author(s)
  Hisamatsu T, Kamada N, Honda H, Kobayashi T, Okamoto S, Hibi T
- Organizer
  the 110th Annual Meeting of the AGA Institute
- Place of Presentation
  Chicago
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病におけるCD14+腸管マクロファージの抗原提示能について2009
- Author(s)
  久松理一、井上詠, 他
- Organizer
  第46回日本消化器免疫学会総会
- Place of Presentation
  松山
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] Role of Lamina Propria Macrophages in the Regulation of Both Th1 and Th17 Immunity in Inflammatory Bowel Diseases2009
- Author(s)
  Kamada N, Hisamatsu T, Kobayashi T, Okamoto S, Inoue N, Kanai T, Hibi T.
- Organizer
  14th International Congress of Mucosal Immunology
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] アミノ酸が直接炎症を抑える2009
- Author(s)
  久松理一
- Organizer
  第2回名古屋栄養セミナー
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 自然免疫と消化器疾患クローン病では腸管マクロファージと腸管NK細胞の interaction がIFNγ産生に関与する2009
- Author(s)
  久松理一, 高山哲朗, 日比紀文
- Organizer
  JDDW 2009
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] シンポジウム1 消化器疾患と樹状細胞:病態の解明と治療法の開発クローン病におけるCD14+腸管マクロファージの抗原提示能について2009
- Author(s)
  久松理一, 鎌田信彦, 本田治樹, 北爪美奈, 井上詠, 岡本晋, 金井隆典, 日比紀文
- Organizer
  第46回日本消化器免疫学会総会
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病の腸管局所で何が起こっているか?ヒトサンプルを用いた研究から2009
- Author(s)
  久松理一
- Organizer
  箱根山シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] Unique intestinal dendritic cell-like macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFNg axis.2008
- Author(s)
  Tadakazu, Hisamatsu
- Organizer
  8th Colloquium for the Study of Gastrointestinal Defense System
- Place of Presentation
  Osaka
- Year and Date
  2008-01-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Pathogenesis of IBD : How much progress did we make? Roles of Macrophages in IBD : Pathogenic or Protective?2008
- Author(s)
  Tadakazu Hisamatsu (invited speaker)
- Organizer
  The 3rd Japan-Korea IBD Symposium, Seoul
- Place of Presentation
  Korea
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] Unique intestinal denctritic cell-like macrophages contribute to the path ogenesis of Crohn's disease via IL-23/IFNg axis2008
- Author(s)
  Tadakazu Hisamatsu
- Organizer
  8th Colloquium for the Study of Gastrointestinal Defense System
- Place of Presentation
  Osaka
- Year and Date
  2008-01-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] ベーチェット病における抗サイトカイン療法2008
- Author(s)
  久松理一, 長沼誠, 日比紀文
- Organizer
  第36回日本臨床免疫学会総会ミニシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] MCP-1依存性腸管マクロファージサブセットの腸管免疫恒常性における役割2008
- Author(s)
  高田康裕、久松理一、鎌田信彦、斎藤理子、高山哲朗、市川仁志、小林拓、知念寛、井上詠、岡本晋、日比紀文
- Organizer
  第45回日本消化器免疫学会、一般演題
- Place of Presentation
  京都
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] クローン病における腸管マクロファージの腸内細菌認識異常 -IL-23を中心とした慢性炎症サイクル-2008
- Author(s)
  久松理一、鎌田信彦、小林拓、岡本晋、井上詠、緒方晴彦、金井隆典、日比紀文
- Organizer
  第45回日本消化器免疫学会、シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-07-04
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] MCP-1 依存性腸管マクロファージサブセットの腸管免疫恒常性における役割2008
- Author(s)
  高田康裕, 久松理一, 鎌田信彦, 斉藤理子, 高山哲朗, 市川仁志, 小林拓, 知念寛, 井上詠, 岡本晋, 日比紀文
- Organizer
  第45回日本消化器免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病における腸管マクロファージの腸内細菌認識異常-IL-23を中心とした慢性炎症サイクルー2008
- Author(s)
  久松理一、井上詠、他
- Organizer
  第45回日本消化器免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-07-04
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] Unique intestinal dendritic cell-like macrophages contribute to the path ogenesis of Crohn's disease via IL-23/IFNg axis2008
- Author(s)
  Tadakazu Hisamatsu
- Organizer
  8th Colloquium for the Study of Gastrointestinal Defense System
- Place of Presentation
  Osaka
- Year and Date
  2008-01-12
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] 自然免疫細胞と免疫疾患2008
- Author(s)
  久松理一
- Organizer
  第36回日本臨床免疫学会総会ワークショップ
- Place of Presentation
  東京
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] クローン病における腸管マクロファージの腸内細菌認識異常-IL-23を中心とした慢性炎症サイクル-2008
- Author(s)
  久松理一, 鎌田信彦, 小林拓, 岡本晋, 井上詠, 緒方晴彦, 金井隆典, 日比紀文
- Organizer
  第45回日本消化器免疫学会シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] 炎症性腸疾患におけるアミノ酸代紺モニタリングと誌断への応用2008
- Author(s)
  久松理一, 安藤綾俊, 日比紀文
- Organizer
  JDDW 2008 パネルディスカッション
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590749
[Presentation] Abnormally differentiated intestinal macrophages in human Crohn's disease produce excess IL-23 in response to the enteric bacteria2007
- Author(s)
  Kamada N, Hisamatsu T, Chinen H, Kobayashi T, Okamoto S, and Hibi T
- Organizer
  Digestive Disease Week and the 108th Annual Meeting of the AGA Institute
- Place of Presentation
  Washington DC
- Year and Date
  2007-05-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Intestinal macrophages suppress excess immune response to enteric flora and breaking it up causes intestinal inflammation2007
- Author(s)
  Tadakazu Hisamatsu, Nobubiko Kamada, Susumu Okamoto, Toshifumi Hibi
- Organizer
  AGA-JSME joint symposium第93回日本消化器病学会総会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Abnormally differentiated intestinal macrophages in human Crohn's disease produce excess IL-23 in response to the enteric bacteria2007
- Author(s)
  Kamada, N., Hisamatsu, T., Chinen, H., Kobayashi, T., Okamoto, S., Hibi, T
- Organizer
  the 108th Annual Meeting of the AGA Institute
- Place of Presentation
  Washington DC
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Intestinal macrophages in human Crohn's disease produce excess IL-23 in response to commensal bacteria2007
- Author(s)
  Kamada N, Hisamatsu T, Okamoto S, Chinen H, and Hibi T
- Organizer
  13th International Congress of Mucosal Immunology
- Place of Presentation
  Tokyo
- Year and Date
  2007-07-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Abnormally differentiated intestinal macrophages in human crohn'sdisease produce excess IL-23 in response to the enteric bacteria2007
- Author(s)
  Kamada N, Hisamatsu T, Chinen H, Kobayashi T, Okamoto S, Hibi T
- Organizer
  Digestive Disease Week and the 108th Annual Meeting of the AGA Institute
- Place of Presentation
  Washington DC
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Intestinal macrophages suppress excess immune response to enteric flor a and breaking it up causes intestinal inflammation2007
- Author(s)
  Tadakazu Hisamatsu, Nobuhiko Kamada, Susumu Okamoto, and Toshifumi Hibi
- Organizer
  AGA-JSME joint symposium 第93回日本消化器病学会総会
- Place of Presentation
  青森
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Intestinal macrophages in human crohn's disease produce excess IL-23 in response to commensal bacteria2007
- Author(s)
  Kamada N, Hisamatsu T, Okamoto S, Chinen H, Hibi T
- Organizer
  13th International Congress of Mucosal Immunology
- Place of Presentation
  Tokyo
- Year and Date
  2007-07-10
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] Intestinal macrophages suppress excess immune response to enteric flora and breaking it up causes intestinal inflammation.2007
- Author(s)
  Tadakazu, Hisamatsu, Nobuhiko, Kamada, Susumu, Okamoto, Toshifumi, Hibi
- Organizer
  AGA-JSME joint symposium
- Place of Presentation
  Aomori
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] クローン病における腸管マクロファージによる腸内細菌認識異常とTh-1誘導-マクロファージを中心とした炎症サイクル-2007
- Author(s)
  久松理一, 鎌田信彦, 岡本晋, 日比紀文
- Organizer
  第93回日本消化器病学会総会シンポジウム
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-18590700
[Presentation] クローン病における腸管マクロファージによる腸内細菌認識異常とTh-1誘導-マクロファージを中心とした炎症サイクル2007
- Author(s)
  久松理一, 鎌田信彦, 岡本晋, 日比紀文
- Organizer
  第93回日本消化器病学会総会シンポジウム
- Place of Presentation
  青森
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590700

1. KANAI Takanori (40245478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
2. HIBI Toshifumi (50129623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 54 results
3. INOUE Nagamu (00232546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. OKAMOTO Susumu (70255446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. WATANABE Mamoru (10175127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MORIMOTO Chikao (30119028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOKUTAKE Mina (30468524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIHARA Kazuyuki (00212910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKUDA Katsuji (40085741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIURA Tadashi (10266570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHIDA Jiro (50198470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Hayashida Mari (60754364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 長沼誠 (00265810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 杉浦悠毅 (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 北洞哲治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大塚和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岩男泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hisamatsu Tadakazu 久松 理一

HISAMATSU Tadakazu 久松 理一

久松 理一 ヒサマツ タダカズ

Research Projects

Research Products

Co-Researchers

免疫プロファイルの包括的評価による病態に基づく炎症性腸疾患の新規分類と治療有効性Principal Investigator

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Development of therapeutic effect prediction tool for molecular-targeted drugs in inflammatory bowel disease using machine learningPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Investigating the anti-inflammatory mechanism of 5-ASA and exploring the new therapeutic strategy for IBD by the comprehensive analysis for the gut microbiomePrincipal Investigator

Principal Investigator

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Review Section

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Functional analysis of SLCO2A1 transporter

Principal Investigator

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Elucidation of regulation of intestinal macrophage differentiation from intracellular energy metabolismPrincipal Investigator

Principal Investigator

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To identify the mechanism of inflammatory bowel disease by using human microbe mono-associated mouse

Principal Investigator

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Elucidation of the pathology and treatment of refractory small intestinal ulcer disease using genetically engineered mouse and PG mass spectrometryPrincipal Investigator

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Mucosal IgG plasma cell as a novel therapeutic target in the pathogenesis of ulcerative colitis .Principal Investigator

Principal Investigator

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Investigation of intestinal macrophage in contribution to gut immune homeostasis and its disruption in Crohn's disease

Principal Investigator

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Elucidation of intestinal mucosal immune system through the intracellular processing mechanisms of bacteria and its application for novel therapy of inflammatory bowel disease

Principal Investigator

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Development of a biomarker for inflammatory bowel disease by plasma amino acids profile.Principal Investigator

Principal Investigator

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Analysis of abnormal function of immunosuppressive intestinal macrophages in Crohn diseasePrincipal Investigator

Principal Investigator

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Research Institution

腸上皮細胞におけるNOD2の細胞内局在とpathogen認識メカニズムの解明Principal Investigator

Principal Investigator

Hisamatsu Tadakazu 久松理一

HISAMATSU Tadakazu 久松理一

久松理一ヒサマツタダカズ

[Book] 腸管粘膜マクロファージによる腸管ホメオスターシスとその破綻分子消化器病 vol.4 No.22007