Hhanaki Hideaki 花木秀明

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Hanaki Hideaki 花木秀明

HANAKI Hideaki 花木秀明

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Researcher Number	60286747
Other IDs
External Links
Affiliation (Current)	2025: 北里大学, 大村智記念研究所, 教授 2025: 北里大学, 感染制御科学府, 教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 北里大学, 大村智記念研究所, 教授 2020: 北里大学, 大村智記念研究所, 特任教授 2015 – 2019: 北里大学, 北里生命科学研究所, 特任教授 2016: 北里大学, 大学院感染制御科学府, 教授 2014: 北里大学, 北里生命科学研究所, 教授 2011: 北里大学, 北里生命科学研究所, 室長 1997 – 2000: 順天堂大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Infectious disease medicine Except Principal Investigator Basic Section 55020:Digestive surgery-related / Bioorganic chemistry / Obstetrics and gynecology / Bacteriology (including Mycology) / Bioproduction chemistry/Bioorganic chemistry
Keywords	Principal Investigator hetero-VISA / 薬剤耐性 / Staphylococcus aureus / ヘテロ耐性 / MRSA / hVISA / MALDI-TOFMS / 耐性 / VRSA / Vancomycin … More / 混合培養 / 検出 / ヘテロVISA / VISA / バンコマイシン … More Except Principal Investigator hetero-VRSA / VRSA / vancomycin / MRSA / SCCmec / cell wall / 天然物化学 / 抗生物質 / 薬剤耐性克服 / 抗菌薬適正使用 / 周術期予防抗菌薬 / 腎機能低下 / 組織内濃度 / 血中濃度 / CMZ / 消化器外科 / CMZ血中濃度 / CMZ血清濃度 / CMZ組織内濃度 / 手術部位感染 / 下部消化管外科 / 血清濃度 / 組織濃度 / cefmetazole / グラム陰性病原細菌 / 酵素阻害物質 / メタロ-β-ラクタマーゼ / 薬剤耐性菌 / スクリーニング / 微生物化学 / 薬剤耐性 / ＧＢＳ新規検出法 / GBS新規検出法 / 診療所 / 迅速診断 / イムノクロマト法 / GBS特異 Sip 抗原 / Streptococcus agalactiae / ccrB / ccrA / resistance / hetoro-VRSA / ヘテロVRSA / CcrB / CcrA / 細胞壁 / herero-VRSA / バンコマイシン / Ccr B / Ccr A / SCC mec / glycopeptide / teicoplanin / peptidoglycan / Staphylococcus aureus / 細胞壁合成 / genotyping / PBP / 疫学 / ムレインモノアー / hetero- VRSA / 併用療法 / 細胞集団解析 / affinity trapping / ムレインモノマー / バンコマイシン耐性 / アミノグリコシド抗生物質 / 微生物代謝産物 / アルベカシン耐性 / アルベカシン Less

Scientific validation of prophylactic antimicrobials by measuring their concentration at the site of infection
- Principal Investigator
  
  Takayama Yoko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kitasato University
Immunochromatography for rapid detection of Streptococcus agalactiae in pregnant women
- Principal Investigator
  
  Takayama Yoko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kitasato University
Investigation of detection method for Vancomycin intermediated-resistant Staphylococcus aureusPrincipal Investigator
- Principal Investigator
  
  Hanaki Hideaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kitasato University
Search for metallo-beta-lactamase inhibitors produced by microorganisms
- Principal Investigator
  
  Shiomi Kazuro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kitasato University
Search for circumventors of arbekacin resistance in MRSA produced by microorganisms
- Principal Investigator
  
  SHIOMI Kazuro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Kitasato University
Epidemiology of MRSA in the world and mechanism of vancomycin resistance
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Special Purpose.
- Research Institution
  JUNTENDO UNIVERSITY
Emergence of vancomycin-resistant MRSA and its countermesures
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University

All 2022 2015 2014 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] Association of serum and fat tissue antibiotic concentrations with surgical site infections in lower gastrointestinal surgery2022
- Author(s)
  Takayama Y, Komatsu T, Nakamura T, Tomoda Y, Toda M, Miura H, Sato T, Atsuda K, Okamoto H, Hanaki H.
- Journal Title
  
  Surgery
  
  Volume: 171 Issue: 4 Pages: 1000-1005
- DOI
  10.1016/j.surg.2021.10.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08630
[Journal Article] Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery.2022
- Author(s)
  Komatsu T, Morita H, Takayama Y, Natsume Y, Tomoda Y, Miura H, Sato T, Nakamura T, Toda M, Okamoto H, Hanaki H, Atsuda K
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 28 Issue: 8 Pages: 1105-1111
- DOI
  10.1016/j.jiac.2022.03.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08630
[Journal Article] Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2")2012
- Author(s)
  T. Suga, T. Ishii, M. Iwatsuki, T. Yamamoto, K. Nonaka, R. Masuma, H. Matsui, H. Hanaki, S. Omura, K. Shiomi
- Journal Title
  
  J. Antibiot
  
  Volume: 65 Issue: 10 Pages: 527-529
- DOI
  10.1038/ja.2012.53
- NAID
  10031121426
- Year and Date
  2012-07-04
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129
[Journal Article] Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-44292011
- Author(s)
  M. Iwatsuki, T. Ishimori, T. Yamamoto, K. Takata, M. Mori, K. Nonaka, R. Masuma, Y. Hayakawa, H. Hanaki, K. Shiomi, S. Omura
- Journal Title
  
  Tetrahedron
  
  Volume: Vol.67, No.35 Pages: 6644-6648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129
[Journal Article] Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp.FKI-44292011
- Author(s)
  M.Iwatsuki, T.Ishimori, T.Yamamoto, K.Takata, M.Mori, K.Nonaka, R.Masuma, Y.Hayakawa, H.Hanaki, K.Shiomi, S.Omura
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 35 Pages: 6644-6648
- DOI
  10.1016/j.tet.2011.05.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129, KAKENHI-PROJECT-22603011
[Journal Article] Identification of the active component that induces vancomycin resistance in MRSA2010
- Author(s)
  S. Ikeda, H. Hanaki, C. Yanagisawa, Y. Ikeda-Dantsuji, H. Matsui, M. Iwatsuki, K. Shiomi, T. Nakae, K. Sunakawa, S. Omura
- Journal Title
  
  J. Antibiot
  
  Volume: Vol.63, No.9 Pages: 533-538
- NAID
  10030709962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129
[Journal Article] Identification of the active component that induces vancomycin resistance in MRSA2010
- Author(s)
  S.Ikeda, H.Hanaki, C.Yanagisawa, Y.Ikeda-Dantsuji, H.Matsui, M.Iwatsuki, K.Shiomi, T.Nakae, K.Sunakawa, S.Omura
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 63巻 Pages: 533-538
- NAID
  10030709962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129
[Patent] 新規メタロ-β-ラクタマーゼ阻害剤2015
- Inventor(s)
  大村智、塩見和朗、浅見行弘、野中健一、鹿島由衣、花木秀明
- Industrial Property Rights Holder
  北里大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-061943
- Filing Date
  2015-03-25
- Data Source
  KAKENHI-PROJECT-26450142
[Patent] 新規FKI-4429物質およびその製造方法2011
- Inventor(s)
  S.Omura, M.Iwatsuki, R.Masuma, K.Nonaka, T.Yamamoto, H.Hanaki, K.Shiomi
- Industrial Property Rights Holder
  The Kitasato Institute
- Filing Date
  2011-03-09
- Overseas
- Data Source
  KAKENHI-PROJECT-21580129
[Patent] Novel FKI-4429 substance and method for producing same2011
- Inventor(s)
  S. Omura, M. Iwatsuki, R. Masuma, K. Nonaka, T. Yamamoto, H. Hanaki, K. Shiomi
- Industrial Property Rights Holder
  The Kitasato Institute
- Filing Date
  2011-03-09
- Overseas
- Data Source
  KAKENHI-PROJECT-21580129
[Patent] 新規FKI-4429物質およびその製造方法2010
- Inventor(s)
  大村智,岩月正人,増間碌郎,野中健一,山本剛,花木秀明,塩見和朗
- Industrial Property Rights Holder
  (学)北里研究所
- Industrial Property Number
  2010-052838
- Filing Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21580129
[Patent] 新規FKI-4429物質およびその製造方法2010
- Inventor(s)
  大村智, 岩月正人, 増間碌郎, 野中健一, 山本剛, 花木秀明, 塩見和朗
- Industrial Property Rights Holder
  (学)北里研究所
- Industrial Property Number
  2010-052838
- Filing Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] New metallo-beta-lactamase inhibitor produced by Paecilomyces sp. FKI-68012015
- Author(s)
  K. Shiomi, Y. Kashima, T. Suga, Y. Asami, T. Ishii, M. Iwatsuki, K. Nonaka, H. Matsui, H. Hanaki, S. Omura
- Organizer
  ICAAC/ICC 2015
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450142
[Presentation] VISAとその前駆体であるヘテロVISAを考える2014
- Author(s)
  花木秀明
- Organizer
  第62回日本化学療法学会西日本支部総会第57回日本感染症学会中日本地方会学術集会第84回日本感染症学会西日本地方会学術集会合同学会
- Place of Presentation
  岡山コンベンションセンター, 岡山県
- Year and Date
  2014-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-26461513
[Presentation] A MODIFIED AGAR SCREENING METHOD FOR DETECTION OF HETEROGENEOUS VANCOMYCIN-INTERMEDIATE STAPHYLOCOCCUS AUREUS2014
- Author(s)
  Longzhu Cui, Hidehito Matsui and Hideaki Hanaki
- Organizer
  24th European Congress of Clinical Microbiology and Infectious Diseases
- Place of Presentation
  Centre Convencions Internacional Barcelona, Barcelona, Spain
- Year and Date
  2014-05-13
- Data Source
  KAKENHI-PROJECT-26461513
[Presentation] MRSAの基礎2014
- Author(s)
  花木秀明
- Organizer
  第88回日本感染症学会学術集会第62回日本化学療法学会総会合同学会
- Place of Presentation
  ヒルトン福岡シーホーク, 福岡県
- Year and Date
  2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-26461513
[Presentation] 微生物代謝産物からのMRSAに対するアルベカシン耐性克服物質の探索2012
- Author(s)
  須賀拓弥, 石井貴広, 岩月正人, 山本剛, 野中健一, 松本厚子, 増間碌郎, 高橋洋子, 花木秀明, 大村智, 塩見和朗
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] 抗MRSA活性を有するNaphthacemycin-A9の全合成2012
- Author(s)
  小嶋康裕, 廣瀬友靖, 菅原章公, 塩見和朗, 花木秀明, 大村智, 砂塚敏明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] MRSA活性を有するNaphthacemycin類の全合成研究2011
- Author(s)
  小嶋康裕, 廣瀬友靖, 木村紗穂莉, 菅原章公, 塩見和朗, 花木秀明, 大村智, 砂塚敏明
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] 抗MRSA活性を有するNaphthacemycin類の全合成研究2011
- Author(s)
  小嶋康裕, 廣瀬友靖, 木村紗穂莉, 菅原章公, 塩見和朗, 花木秀明, 大村智, 砂塚敏明
- Organizer
  第99回有機合成シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] アルベカシン耐性MRSAの耐性克服物質の探索2011
- Author(s)
  高田恵子, 岩月正人, 山本剛, 石森敏也, 野中健一, 増間碌郎, 松井秀仁, 花木秀明, 早川洋一, 大村智, 塩見和朗
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] 薬剤耐性菌に対して耐性克服活性を示す微生物代謝産物の探索2011
- Author(s)
  須賀拓弥, 石井貴広, 岩月正人, 野中健一, 松本厚子, 増間碌郎, 高橋洋子, 花木秀明, 塩見和朗, 大村智
- Organizer
  第14回北里微生物アカデミー
- Place of Presentation
  相模原
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] 微生物代謝産物からのMRSAに対するアルベカシン耐性克服活性物質の探索2011
- Author(s)
  須賀拓弥, 石井貴広, 岩月正人, 野中健一, 増間碌郎, 花木秀明, 大村智, 塩見和朗
- Organizer
  第7回北里化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] アルベカシン耐性MRSAに対する耐性克服物質の探索2010
- Author(s)
  岩月正人, 山本剛, 石森敏也, 高田恵子, 野中健一, 増間碌郎, 松井秀仁, 花木秀明, 早川洋一, 塩見和朗, 大村智
- Organizer
  第23回北里バイオサイエンスフォーラム
- Place of Presentation
  十和田
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] アルベカシン耐性MRSAの耐性克服物質の探索2010
- Author(s)
  石森敏也, 岩月正人, 山本剛, 高田恵子, 野中健一, 増間碌郎, 松井秀仁, 花木秀明, 早川洋一, 塩見和朗, 大村智
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21580129
[Presentation] 抗MRSA活性を有するNaphthacemycin類の全合成研究2010
- Author(s)
  砂塚敏明, 小嶋康裕, 廣瀬友靖, 塩見和朗, 花木秀明, 大村智
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21580129

1. CUI Longzhu (50306932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. SHIOMI Kazuro (40235502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. HIRAMATSU Keiichi (10173262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ITO Teruyo (10095763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Takayama Yoko (80286278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. TAKAHASHI Yoko (80197186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. MASUMA Rokuro (90219353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. IWATSUKI Masato (70353464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. SASAKI Kazumi (90276478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KUWAHARA Kyoko (10167976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KURODA Makoto (80317411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. BABA Tadashi (30317458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ASAMI Yukihiro (70391844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. MATSUMOTO Atsuko (20300759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 堀典子 (50245700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村隆俊 (10286304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 厚田幸一郎 (20306658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. KONDO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hhanaki Hideaki 花木 秀明

Hanaki Hideaki 花木 秀明

HANAKI Hideaki 花木 秀明

Research Projects

Research Products

Co-Researchers

Scientific validation of prophylactic antimicrobials by measuring their concentration at the site of infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunochromatography for rapid detection of Streptococcus agalactiae in pregnant women

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of detection method for Vancomycin intermediated-resistant Staphylococcus aureusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for metallo-beta-lactamase inhibitors produced by microorganisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for circumventors of arbekacin resistance in MRSA produced by microorganisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epidemiology of MRSA in the world and mechanism of vancomycin resistance

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Emergence of vancomycin-resistant MRSA and its countermesures

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association of serum and fat tissue antibiotic concentrations with surgical site infections in lower gastrointestinal surgery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2")2012

Author(s)

Journal Title

DOI

NAID

Year and Date

Data Source

[Journal Article] Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-44292011

Author(s)

Journal Title

Data Source

[Journal Article] Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp.FKI-44292011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the active component that induces vancomycin resistance in MRSA2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Identification of the active component that induces vancomycin resistance in MRSA2010

Author(s)

Hhanaki Hideaki 花木秀明

Hanaki Hideaki 花木秀明

HANAKI Hideaki 花木秀明