takebayashi minoru 竹林実

… Alternative Names

TAKEBAYASHI Minoru 竹林実

竹林実タケバヤシミノル

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Researcher Number	60304440
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 熊本大学, 大学院生命科学研究部(医), 教授 2018 – 2019: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 2016 – 2017: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他(移行) 2015: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 2015: 国立病院機構呉医療センター, 精神科, 科長 … More 2012 – 2013: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 2011: 独立行政法人国立病院機構(呉医療センター臨床研究部), 精神科, 科長 2010: 国立病院機構呉医療センター精神科, 臨床研究部, 科長・室長 2010: 独立行政法人国立病院機構(呉医療センター臨床研究部), 呉医療センター臨床研究部, 室長・精神科科長 2009: 独立行政法人国立病院機構(呉医療センター臨床研究部), 精神科・臨床研究部, 科長・室長 2008: Department of Clinical Research, National Hospital Organization Kure Medical Center, 呉医療センター臨床研究部, 室長・精神科科長 2000: 広島大, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 52030:Psychiatry-related / Complex systems
Keywords	Principal Investigator 抗うつ薬 / グリア / うつ病 / 創薬 / アストロサイト / リゾリン脂質 / リゾフォスファチジン酸受容体１ / リゾリン脂質代謝 / 抗うつ薬受容体 / 神経栄養因子 … More / 患者層別化 / 層別化 / リン脂質 / オートタキシン / 脂質メディエーター / リゾホスファチジン酸１受容体 / うつ病バイオマーカー / DHA-LPA / 抗うつ薬創薬 / LPA受容体 / バイオマーカー / LPA1受容体 / 栄養療法 / リゾフォスファチジン酸 / リゾホスファチジン酸受容体１ / 気分障害 / GDNF / monoamine-independent / astrocyte / glia / antidepressant / プロテオミクス / 繊維芽細胞成長因子受容体 / アフィニティクロマトグラフィ / 精神薬理学 … More Except Principal Investigator うつ病 / MRI / バイオマーカー / 精神疾患 / 視える化 / 高齢者 / 海馬 / アストロサイト / 電気けいれん療法 / 拡散MRI / うつ病治療 / 高精細MRI / 拡散画像 / ゲーム障害 / 早期スクリーニング / 脳画像 / 人工知能 / ゲーム症 / 言語 / 情動 / 身体自己像 / 対人コミュニケーション / 神経モジュレーション / Quality of Life / 社会的孤立 / 自己制御精神 / 身体像 / 社会的文脈 / 発達 / 心理社会的介入 / 分子 / 社会行動障害 / 自己制御修復 / メタ認知 / 摂食障害 / 気分障害 / 統合失調症 / 思春期 / 前頭前野 / 自己制御 Less

革新的高精細MRI画像による神経炎症に着目した高齢者うつ病の病態解明
- Principal Investigator
  
  北島美香
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kumamoto University
Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressantsPrincipal Investigator
- Principal Investigator
  
  竹林実
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
Challenge to "visualize mental illness" to realize a symbiotic society with illness
- Principal Investigator
  
  大山要
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
海馬アストロサイトに着目した電気けいれん療法の作用機序解明
- Principal Investigator
  
  朴秀賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
Can we prevent the social penetration of gaming disorder? Basic research for integrated scientific evaluation and early countermeasures against gaming disorder
- Principal Investigator
  
  大山要
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Neuroimaging biomarkers using high-resolution MRI for treatment effect assessment of depression focusing on glia
- Principal Investigator
  
  Kitajima Mika
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kumamoto University
Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)Principal Investigator
- Principal Investigator
  
  Takebayashi Minoru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
  Department of Clinical Research, National Hospital Organization Kure Medical Center
A pharmacological and clinical study of G protein-coupled antidepressant receptors on astrocytesPrincipal Investigator
- Principal Investigator
  
  Takebayashi Minoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Identification of novel targets of antidepressant on glia by using pharmacoproteomicsPrincipal Investigator
- Principal Investigator
  
  TAKEBAYASHI Minoru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Integrating molecular and psychosocial approach for assisting adolescent mind development and self-regulation
- Principal Investigator
  
  Kasai Kiyoto
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in gliaPrincipal Investigator
- Principal Investigator
  
  TAKEBAYASHI Minoru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  国立病院機構呉医療センター精神科
   Department of Clinical Research, National Hospital Organization Kure Medical Center
ニューロステロイドの細胞保護作用および調節メカニズムに関する検討Principal Investigator
- Principal Investigator
  
  竹林実
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Hiroshima University

[Book] うつ病診療の論理と倫理＜精神医学の基盤＞2015
- Author(s)
  竹林　実、山脇成人
- Total Pages
  203
- Publisher
  学樹書院
- Data Source
  KAKENHI-PROJECT-15K09819
[Book] 気分障害のグリア仮説から創薬へ向けて気分障害の薬理・生化学-うつ病の脳内メカニズム研究:進歩と挑戦-躁うつ病薬理生化学研究懇話会編2012
- Author(s)
  竹林実
- Publisher
  医薬ジャーナル社大阪
- Data Source
  KAKENHI-PROJECT-23591686
[Book] 気分障害の薬理・生化学－うつ病の脳内メカニズム研究：進歩と挑戦－2012
- Author(s)
  竹林　実
- Total Pages
  335
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23591686
[Book] Recent Developments on Depression Research2009
- Author(s)
  Takebayashi M
- Total Pages
  256
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-20591384
[Book] Recent Developments on Depression Research. (Shirayama Y, Chaki S (eds))2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Publisher
  Glial dysfunction in mood disorders : the role of GDNF.
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Identification of the antidepressant effect of electroconvulsive stimulation-related genes in hippocampal astrocyte2024
- Author(s)
  Miyako K, Kajitani N, Koga Y, Takizawa H, Boku S, Takebayashi M
- Journal Title
  
  J Psychiatr Res
  
  Volume: 170 Pages: 318-327
- DOI
  10.1016/j.jpsychires.2024.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07599, KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.2024
- Author(s)
  Kajitani, N., Okada-Tsuchioka, M., Inoue, A., Miyano, K., Masuda, T., Boku, S., Iwamoto, K., Ohtsuki, S., Uezono, Y., Aoki, J., Takebayashi, M.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 49 Issue: 3 Pages: 561-572
- DOI
  10.1038/s41386-023-01727-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07750, KAKENHI-PROJECT-21K07501, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K27530
[Journal Article] TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice2024
- Author(s)
  Koga Yusaku、Kajitani Naoto、Miyako Kotaro、Takizawa Hitoshi、Boku Shuken、Takebayashi Minoru
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 170 Pages: 375-386
- DOI
  10.1016/j.jpsychires.2024.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] Serum levels of high mobility group box‐1 protein (<scp>HMGB1</scp>) and soluble receptors of advanced glycation end‐products (<scp>RAGE</scp>) in depressed patients treated with electroconvulsive therapy2023
- Author(s)
  Abe Hiromi、Okada‐Tsuchioka Mami、Kajitani Naoto、Omori Wataru、Itagaki Kei、Shibasaki Chiyo、Boku Shuken、Matsuhisa Tetsuaki、Takebayashi Minoru
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 43 Issue: 3 Pages: 359-364
- DOI
  10.1002/npr2.12358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-23K27530
[Journal Article] Tetraspanin heterogeneity of small extracellular vesicles in human biofluids and brain tissue2022
- Author(s)
  Okada-Tsuchioka Mami、Kajitani Naoto、Omori Wataru、Kurashige Takashi、Boku Shuken、Takebayashi Minoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 627 Pages: 146-151
- DOI
  10.1016/j.bbrc.2022.08.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-21K07536, KAKENHI-PROJECT-18H02756
[Journal Article] G protein-biased LPAR1 agonism promotes prototypic antidepressant effects2022
- Author(s)
  Kajitani Naoto、Okada-Tsuchioka Mami、Inoue Asuka、Miyano Kanako、Masuda Takeshi、Boku Shuken、Iwamoto Kazuya、Ohtsuki Sumio、Uezono Yasuhito、Aoki Junken、Takebayashi Minoru
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 514841-514841
- DOI
  10.1101/2022.11.02.514841
- Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-18H02756
[Journal Article] 単極性気分障害（うつ病）を治療するための標準的知識と技術2021
- Author(s)
  竹林実
- Journal Title
  
  精神科治療学
  
  Volume: 36(3) Pages: 251-255
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice2021
- Author(s)
  Ito Naofumi、(24/28)
- Journal Title
  
  Science Translational Medicine
  
  Volume: 13 Issue: 587 Pages: 7896-7896
- DOI
  10.1126/scitranslmed.aay7896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0071, KAKENHI-PROJECT-20K20520, KAKENHI-PROJECT-20K21425, KAKENHI-PUBLICLY-19H04775, KAKENHI-PUBLICLY-19H04757, KAKENHI-PUBLICLY-19H04784, KAKENHI-PUBLICLY-19H04785, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-20H03565, KAKENHI-PROJECT-18K19376, KAKENHI-PROJECT-18KK0213, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H03351, KAKENHI-PROJECT-18H02756, KAKENHI-PROJECT-19H03341, KAKENHI-PROJECT-20K06670, KAKENHI-PROJECT-21K19307
[Journal Article] 気分障害におけるグリア研究と創薬に向けた試み2021
- Author(s)
  竹林実
- Journal Title
  
  日本生物学的精神医学雑誌
  
  Volume: 32(1) Pages: 44-50
- NAID
  130008003202
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] 脳内変化を反映する脳由来エクソソームに着目したうつ病の診断および治療反応性バイオマーカーの探索研究2021
- Author(s)
  岡田麻美，大盛航，梶谷直人，竹林実
- Journal Title
  
  医療の広場
  
  Volume: 61(8) Pages: 11-14
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region.2021
- Author(s)
  1.Ikegame T, Hidaka Y, Nakachi Y, Murata Y, Watanabe R, Sugawara H, Asai T, Kiyota E, Saito T, Ikeda M, Sasaki T, Hashimoto M, Ishikawa T, Takebayashi M, Iwata N, Kakiuchi C, Kato T, Kasai K, Bundo M, Iwamoto K
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 11;11(1) Issue: 1 Pages: 119-119
- DOI
  10.1038/s41398-021-01242-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15486, KAKENHI-INTERNATIONAL-16K21720, KAKENHI-PLANNED-18H05435, KAKENHI-PROJECT-19K17056, KAKENHI-PLANNED-16H06399, KAKENHI-PLANNED-18H05430, KAKENHI-PROJECT-18H02753, KAKENHI-PROJECT-18H02756
[Journal Article] Decreased serum levels of thrombospondin-1 in female depressed patients.2020
- Author(s)
  Okada-Tsuchioka M，Omori W，Kajitani N，Shibasaki C，Itagaki K，Takebayashi M．
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 40 Pages: 39-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain．2020
- Author(s)
  Kajitani N，Okada-Tsuchioka M，Kano K，Omori W，Boku S，Aoki J，Takebayashi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain2020
- Author(s)
  Kajitani Naoto、Okada-Tsuchioka Mami、Kano Kuniyuki、Omori Wataru、Boku Shuken、Aoki Junken、Takebayashi Minoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 2 Pages: 89-95
- DOI
  10.1016/j.bbrc.2020.05.068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02756, KAKENHI-PROJECT-18K07620
[Journal Article] Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes2020
- Author(s)
  Hisaoka‐Nakashima Kazue、Yokoe Toshiki、Watanabe Shintaro、Nakamura Yoki、Kajitani Naoto、Okada‐Tsuchioka Mami、Takebayashi Minoru、Nakata Yoshihiro、Morioka Norimitsu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: in press Issue: 4 Pages: 849-864
- DOI
  10.1111/jnc.15227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02756, KAKENHI-PROJECT-18K07620
[Journal Article] Reduced serum and cerebrospinal fluid levels of autotaxin in major depressive disorder.2019
- Author(s)
  Itagaki K，Takebayashi M，Abe H，Shibasaki C，Kajitani N，Okada-Tsuchioka M，Hattori K，Yoshida S，Kunugi H，Yamawaki S．
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 22 Pages: 261-269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02756
[Journal Article] Antidepressant amitriptyline‐induced matrix metalloproteinase‐9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line‐derived neurotrophic factor mRNA expression in rat astroglial cells.2019
- Author(s)
  Abe Hiromi、Kajitani Naoto、Okada‐Tsuchioka Mami、Omori Wataru、Yatsumoto Masahide、Takebayashi Minoru
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 印刷中 Issue: 3 Pages: 156-163
- DOI
  10.1002/npr2.12055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07620, KAKENHI-PROJECT-18K15534, KAKENHI-PROJECT-18H02756
[Journal Article] Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes.2017
- Author(s)
  Hisaoka-Nakashima K, Matsumoto C, Azuma H, Taki S, Takebayashi M, Nakata Y, Morioka N
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 40 Pages: 1759-1766
- NAID
  130006110587
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09819
[Journal Article] The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells2016
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka M, Yano R, Itagaki K, Shibasaki C, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 907-912
- DOI
  10.1016/j.bbrc.2016.09.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Identification of lysophosphatidic acid receptor 1 in astroglial cells as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants.2016
- Author(s)
  Kajitani, N., Miyano, K., Okada-Tsuchioka, M., Abe, H., Itagaki, K., Hisaoka-Nakashima, K., Morioka, N., Uezono, Y., Takebayashi, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 53 Pages: 27364-27370
- DOI
  10.1074/jbc.m116.753871
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.2016
- Author(s)
  Hisaoka-Nakashima K, Kajitani N, Kaneko M, Shigetou T, Kasai M, Matsumoto C, Yokoe T, Azuma H, Takebayashi M, Morioka N, Nakata Y.
- Journal Title
  
  Brain Research
  
  Volume: 1634 Pages: 57-67
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819
[Journal Article] Altered serum levels of matrix metalloproteinase-2, -9 in response to electroconvulsive therapy for mood disorders2016
- Author(s)
  Shibasaki C, Takebayashi M, Itagaki K, Abe H, Kajitani N, Okada-Tsuchioka M, Yamawaki S
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 19 Issue: 9 Pages: pyw019-pyw019
- DOI
  10.1093/ijnp/pyw019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819
[Journal Article] Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.2016
- Author(s)
  Hisaoka-Nakashima K, Kajitani N, Kaneko M, Shigetou T, Kasai M, Matsumoto C, Yokoe T, Azuma H, Takebayashi M, Morioka N, Nakata Y
- Journal Title
  
  Brain Res
  
  Volume: 1634 Pages: 57-67
- DOI
  10.1016/j.brainres.2015.12.057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870461, KAKENHI-PROJECT-15K09819
[Journal Article] ricyclic antidepressant amitriptyline-induced glial cell line-derived neurotrophic factor production involves pertussis toxin-sensitive Gi/oactivation in astroglial cells2015
- Author(s)
  Hisaoka-Naashima K, Miyano K, Matsumoto C, Kajitani N , Abe H, Okada-Tsuchioka M, Yokoyama A, Uezono Y, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Pages: 13678-13691
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819
[Journal Article] Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves ERK-dependent EGR1 production in rat primary cultured astrocytes2015
- Author(s)
  Kajitani N, Hisaoka-Nakashima K, Okada-Tsuchioka M, Hosoi M,Yokoe T, Morioka N, Nakata Y , Takebayashi M
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 135 Pages: 27-37
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819
[Journal Article] Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway.2014
- Author(s)
  Morioka N, Suekama K, Zhang FF, Kajitani N, Hisaoka-Nakashima K, Takebayashi M, Nakata Y.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 171(11): Issue: 11 Pages: 2854-67
- DOI
  10.1111/bph.12614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-24790253
[Journal Article] グリアを標的とした新規抗うつ薬創薬2013
- Author(s)
  竹林実
- Journal Title
  
  Depression Frontier
  
  Volume: 11 Pages: 110-119
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT32013
- Author(s)
  Boku S, Nakagawa S,Takamura N, Kato A, Takebayashi M, Hisaoka-Nakashima K, Omiya Y, Inoue T, Kusumi I
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 434 Pages: 779-784
- NAID
  120005460238
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] グリアから見た精神疾患2013
- Author(s)
  竹林実
- Journal Title
  
  精神神経学雑誌
  
  Volume: 115 Pages: 1186-1193
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursors : an involvement of astrocytes.2013
- Author(s)
  Boku S, Hisaoka-Nahashima K, Nakagawa S, Kato A, Kaiitani N, Inoue T, Kusumi I, Takebayashi M
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: 116-124
- DOI
  10.1371/journal.pone.0079371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591667, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-24591673, KAKENHI-PROJECT-25870461
[Journal Article] 気分障害におけるグリア仮説と創薬にむけた試み2013
- Author(s)
  竹林実
- Journal Title
  
  広島医学
  
  Volume: 66 Pages: 611-612
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] うつ病のグリア仮説と創薬の可能性について2012
- Author(s)
  竹林実
- Journal Title
  
  精神科
  
  Volume: 20 Pages: 625-631
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/ Growth Factors : Differential Regulation of FGF-2 by Noradrenaline2012
- Author(s)
  N Kajitani, K Hisaoka-Nakashima, N Morioka, M Okada-Tsuchioka, M Kaneko, M Kasai, C Shibasaki, Y Nakata, M Takebayashi
- Journal Title
  
  PLOS ONE
  
  Volume: 7 Issue: 12 Pages: e51197-e51197
- DOI
  10.1371/journal.pone.0051197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-23790297
[Journal Article] うつ病のグリア仮説と創薬の可能性について2012
- Author(s)
  竹林　実
- Journal Title
  
  精神科
  
  Volume: 21 Pages: 375-381
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor (FGFR) signaling in glial cells: Involvement in glial cell line-derived neurotrophic factor (GDNF) production.2011
- Author(s)
  Hisaoka K, Tsuchioka M, Yano R, Maeda N, Kajitani N, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 21118-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor (FGFR) signaling in glial cells : Involvement in glial cell line-derived neurotrophic factor (GDNF) production2011
- Author(s)
  Hisaoka K, Tsuchioka M, Yano R, Maeda N, Kajitani N, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 21118-28
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production in regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.2011
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajiatani N, Takebayashi M
- Journal Title
  
  Brain Research
  
  Volume: 1384 Pages: 1-8
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production in regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells.2011
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajiatani N, Takebayashi M
- Journal Title
  
  Brain Research 1384
  
  Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Riluzole-induced glial cell line-derived neurotrophic factor production in regulated through fibroblast growth factor receptor signaling in rat C6 glioma cells2011
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajiatani N, Takebayashi M
- Journal Title
  
  Brain Research
  
  Volume: 1384 Pages: 1-8
- Data Source
  KAKENHI-PROJECT-23591686
[Journal Article] Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders.2010
- Author(s)
  Takebayashi M
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 117 Pages: 1119-1121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders.2010
- Author(s)
  Takebayashi M, Hashimoto R, Hisaoka K, Tsuchioka M, Kunugi H
- Journal Title
  
  Journal of Neural Transmission 117
  
  Pages: 1119-1122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] グリアに着目した新しいうつ病治療のメカニズム-気分障害のグリア仮説から創薬にむけて-2010
- Author(s)
  竹林実
- Journal Title
  
  精神神経学雑誌
  
  Volume: 112 Pages: 998-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Prior Neonatal Isolation Reduces Induction of NGF mRNA and Decreases GDNF mRNA in th Hippocampus of Juvenile and Adult Rodents Subjected to Immobilization Stress2008
- Author(s)
  Kawano K, Morinobu S, Sawada T, Tsuji S, Erabi K, Fuchikami M, Kozuru T, Yamawaki S, Hisaoka K, Takebayashi M
- Journal Title
  
  Synapse 62
  
  Pages: 259-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Serotonin(5-HT)induces glial cell line-derived neurotrophic factor(GDNF)mRNA expression via the transactivation of fibroblast growth factor receptor 2(FGFR2)in rat C6 glioma cells2008
- Author(s)
  Tsuchioka M, Takebayashi M, Hisaoka K, Maeda N, Nakata Y.
- Journal Title
  
  Journal of Neurochemistry 106
  
  Pages: 244-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells.2008
- Author(s)
  Tsuchioka M, Takebayashi M, Hisaoka K, Maeda N, Nakata Y
- Journal Title
  
  Journal of Neurochemistry 106
  
  Pages: 244-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells : a possible contribution to GDNF production.2008
- Author(s)
  Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M
- Journal Title
  
  Brain Research 1196
  
  Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Journal Article] Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells : a possible contribution to GDNF production2008
- Author(s)
  Hisaoka K, Maeda N, Tsuchioka M, Takebayashi M
- Journal Title
  
  Brain Research 1196
  
  Pages: 53-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591384
[Patent] ビオチン誘導体又はその生理学的に許容される塩、その製造方法及びそれを用いたアフィニティクロマトグラフィ用材並びにタンパク質の分離方法2008
- Inventor(s)
  竹林実、土岡麻美
- Industrial Property Rights Holder
  竹林実、土岡麻美
- Industrial Property Number
  2008-335333
- Filing Date
  2008-12-26
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 気分障害の過去・現在・未来2023
- Author(s)
  竹林実
- Organizer
  第12回日本精神科医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27530
[Presentation] 三環系抗うつ薬はGタンパク質バイアス型LPA1受容体作動薬として抗うつ効果に関与する2023
- Author(s)
  梶谷直人，岡田麻美，朴秀賢，竹林実
- Organizer
  第45回日本生物学的精神医学会年会
- Data Source
  KAKENHI-PROJECT-23K27530
[Presentation] Identification of anti-depressive effects of electroconvulsive stimulation-related genes in hippocampal astrocytes2023
- Author(s)
  Boku S, Miyako K, Kajitani N, Koga Y, Takebayashi M
- Organizer
  American Congress of Neuropsychopharmacology annual meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07599
[Presentation] ECTの炎症・脂質変化からみたうつ病の病態2022
- Author(s)
  竹林実
- Organizer
  第118回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] うつ病の病態メカニズムにおけるリゾホスファチジン酸受容体の役割2022
- Author(s)
  梶谷直人，岡田麻美，朴秀賢，竹林実
- Organizer
  第44回日本生物学的精神医学会・第32回日本臨床精神神経薬理学会・第52回日本神経精神薬理学会年会・第6回日本精神薬学会総会・学術集会　4学会合同年会(BPCNPPPP4学会合同年会)
- Invited
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Establishment of a clinical setting-associated behavioral model of ECT and investigation of the mechanism of action of ECT with focus on astrocytes2022
- Author(s)
  Kotaro Miyako, Naoto Kajitani, Yusaku Koga, Shuken Boku, Minoru Takebayashi
- Organizer
  Society of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07599
[Presentation] 気分障害におけるグリア病態研究と創薬に向けた試み2020
- Author(s)
  竹林実
- Organizer
  第50回日本神経精神薬理学会年会　第42回日本生物学的精神医学会年会　第4回日本精神薬学会総会・学術集会合同年会ON LINE
- Invited
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Distribution of multiple lysophosphatidic acid receptors in adult mouse brain．2019
- Author(s)
  Kajitani N，Okada-Tsuchioka M，Abe H，Omori W，Itagaki K，Machino A，Takebayashi M．
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Abnormality in metabolism of docosahexaenoic acid-lysophosphatidic acid(DHA-LPA) in major depressive disorder and schizophrenia2019
- Author(s)
  Omori W，Kano K，Hattori K，Kajitani N，Itagaki K，Okada-Tsuchioka M，Abe H，Machino A，Inoue A，Kunugi H，Aoki J，Takebayashi M．
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Antidepressant induces glial cell line-derived neurotrophic factor production through Gαi/o-coupled lysophosphatidic acid receptor 1/Src tyrosine kinase/matrix metalloproteinase-9 cascade in rat astroglial cells．2019
- Author(s)
  Abe H，Kajitani N，Okada-Tsuchioka M，Omori W，Yatsumoto M，Takebayashi M．
- Organizer
  AsCNP2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Altered cerebrospinal fluid levels of matrix metalloproteinases in mood disorders and schizophrenia．2018
- Author(s)
  Omori W,Hattori K,Okada-Tsuchioka M,Itagaki K，Kajitani N，Abe H，Kunugi H，Takebayashi M
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Cellular localization of lysophosphatidic acid receptor 1 in the mouse brain2018
- Author(s)
  Kajitani N，Okada-Tsuchioka M，Abe H，Omori W，Itagaki K，Takebayashi M．
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] 脂質メディエーター・グリア相互作用からみた気分障害の病態と治療2017
- Author(s)
  竹林　実
- Organizer
  第36回リチウム研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] Reduced serum and cerebrospinal fluid levels of autotaxin in major depressive disorder2017
- Author(s)
  Itagaki K, Abe H, Shibasaki C, Omori W, Kajitani N, Abe H, Okada-Tsuchioka M, Hattori K, Yoshida S, Kunugi H, Takebayashi M
- Organizer
  47th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] グリアからみたうつ病の治療戦略について2017
- Author(s)
  竹林　実
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会　合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] Identification of lysophosphatidic acid receptor 1 in astrocytes as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants2017
- Author(s)
  Kajitani N, Miyano K, Okada-Tsuchioka M, Abe H, Omori W, Itagaki K, Uezono Y, Takebayashi M
- Organizer
  47th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] Antidepressant amitriptyline activates matrix metalloproteinase in astroglial cells: involvement in glial cell line-derived neurotrophic factor expression2016
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka, Itagaki K, Shibasaki C, Morioka N, Nakata Y, Takebayashi M
- Organizer
  30th CINP World Congress of Neuropsychopharmacology
- Place of Presentation
  ソウル
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] グリアから謎解く精神疾患のトランスレーショナルリサーチ研究　～気分障害とアストロサイトの観点から～2016
- Author(s)
  竹林　実, 岡田麻美, 柴崎千代, 板垣　圭, 梶谷直人, 安部裕美, 宮野加奈子, 中島一恵, 森岡徳光, 上園保仁
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学学会大会　合同大会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] 抗うつ薬および電気けいれん療法のアストロサイトへの作用からみた気分障害の治療戦略2016
- Author(s)
  竹林　実
- Organizer
  第46回日本神経精神薬理学会年会
- Place of Presentation
  ソウル
- Year and Date
  2016-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] 気分障害のマトリックスメタロプロテアーゼ（MMP）に着目したバイオマーカーおよび創薬に向けた研究2015
- Author(s)
  竹林　実、柴崎千代、安部裕美、板垣　圭、梶谷直人、岡田麻美、中島一恵、森岡徳光、仲田義啓
- Organizer
  第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同大会
- Place of Presentation
  東京
- Year and Date
  2015-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] Antidepressants activate matorix metalloprotease (MMP) in astroglial cells: involvement in glial cell line-derived neurotrophic factor (GDNF) expression.2015
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka, Itagaki K, Morioka N, Nakata Y, Takebayashi M
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  アメリカ　シカゴ
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09819
[Presentation] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursor cells through inducing FGF2 secretion from astrocyte2013
- Author(s)
  Boku S, Hisaoka-Nakashima K, Nakagawa S, Kato A, Kajitani N, Inoue T, Kusumi M, Takebayashi M
- Organizer
  43^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants act directly on astrocytes: role of neurotrophic factor expression2013
- Author(s)
  Takebayashi M
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto
- Invited
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] 抗うつ作用から見たアストロサイトの役割2013
- Author(s)
  竹林　実
- Organizer
  第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会・合同大会（Neuro2013）
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursor cells through inducing FGF2 secretion from astrocyte.2013
- Author(s)
  Boku S, Hisaoka-Nakashima K, Nakagawa S, Kato A, Kajitani N, Inoue T, Kusumi M, Takebayashi M
- Organizer
  43th Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] 初代培養ラット大脳皮質アストロサイトにおいて三環系抗うつ薬アミトリプチリンはMEK/ERKカスケードを介してBDNF exon mRNAの発現を調節する2013
- Author(s)
  中島(久岡)一恵、金子将弘、葛西美穂、梶谷直人、安部裕美、森岡徳光、柴崎千代、仲田義啓、竹林実
- Organizer
  第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会・合同大会(Neuro2013)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants act directly on astrocytes : role of neurotrophic factor expression2013
- Author(s)
  Takebayashi M
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] グリアから見た精神疾患2013
- Author(s)
  竹林　実
- Organizer
  第109回日本精神神経学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] ニューロサイエンスから見たうつ病診断・治療の将来2013
- Author(s)
  竹林　実
- Organizer
  第109回日本精神神経学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursor cells through inducing FGF2 secretion from astrocyte.2012
- Author(s)
  oku S, Hisaoka-Nakashima K, Nakagawa S, Kato A, Kajitani N, Inoue T, Takebayashi M
- Organizer
  51th Annual Meeting of American Colledge of Neuropcychopharmacology
- Place of Presentation
  Frorida
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Distinct regulation of fibroblast growth factor-2 expression by antidepressant and noradrenaline in rat cortical astrocytes2012
- Author(s)
  Kajitani N, Hisaoka-Nakashima K, Morioka N, Okada-Tsuchioka, Shibasaki C, Kaneko M, Kasai M, Nakata Y, Takebayashi M
- Organizer
  42^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] 三環系抗うつ薬amitriptylineによるグリア細胞株由来神経成長因子(GDNF)産生機構におけるマトリックスメタロプロテアーゼ(MMP)の関与2012
- Author(s)
  中島(久岡)一恵、矢野遼也、安部裕美、岡田麻美、梶谷直人、森岡徳光、竹林実、仲田義啓
- Organizer
  第42回日本神経精神薬理学会・第22回日本臨床精神神経薬理学会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] 三環系抗うつ薬amitriptylineによるグリア細胞株由来神経成長因子（GDNF）産生機構におけるマトリックスメタロプロテアーゼ（MMP）の関与2012
- Author(s)
  中島（久岡）一恵、矢野遼也、安部裕美、岡田麻美、梶谷直人、森岡徳光、竹林　実、仲田義啓
- Organizer
  第42回日本神経精神薬理学会・第22回日本臨床精神神経薬理学会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] ラット大脳皮質アストロサイトにおいて、amitriptylineによるFGF-2の発現は複数の受容体型チロシンキナーゼを介して調節される2012
- Author(s)
  細井茉由、岡田麻美、梶谷直人、矢野遼也、柴崎千代、久岡一恵、森岡徳光、仲田義啓、竹林実
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] 抗うつ薬がラット初代培養アストロサイトのBDNF exon mRNAの発現に及ぼす効果2012
- Author(s)
  金子将弘、久岡一恵、梶谷直人、葛西美穂、岡田麻美、森岡徳光、竹林実、仲田義啓
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Distinct regulation of fibroblast growth factor-2 expression by antidepressant and noradrenaline in rat cortical astrocytes.2012
- Author(s)
  Kajitani N, Hisaoka-Nakashima K, Morioka N, Okada-Tsuchioka, Shibasaki C, Kaneko M, Kasai M, Nakata Y, Takebayashi M
- Organizer
  42th Annual Meeting of Society for Neuroscience
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Substance P release occurs from the rat striatum after intraplantar formalin injection to suppress nociceptive responses via activation of neurokinin 1 receptor2012
- Author(s)
  Nakamura Y, Izumi H, Morioka N, Hisaoka KN, Takebayashi M, Nakata Y
- Organizer
  42th Annual Meeting of Society for Neuroscience
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursor cells through inducing FGF2 secretion from astrocyte2012
- Author(s)
  Boku S, Hisaoka-Nakashima K, Nakagawa S, Kato A, Kajitani N, Inoue T, Takebayashi M
- Organizer
  51^<th> Annual Meeting of American Colledge of Neuropcychopharmacology
- Place of Presentation
  Frorida
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] The increase of FGF-2 expression by amitryptyline and noradrenaline could be mediated different mechanisms in rat primary cultured astrocytes2011
- Author(s)
  Kajitani N, Hisaoka K, Kaneko M, Kasai M, Yano R, Okada-Tsuchioka, Morioka N, Takebayashi M, Nakata Y
- Organizer
  2^<nd> Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells : Involvement in glial cell line-derived neurotrophic factor (GDNF) production2011
- Author(s)
  Hisaoka K, TakebayashiM, Okada-Tsuchioka M, Yano R, Kajitani N, Morioka N, Nakata Y
- Organizer
  2^<nd> Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] The increase of FGF-2 expression by amitryptyline and noradrenaline could be mediated different mechanisms in rat primary cultured astrocytes.2011
- Author(s)
  Kajitani N, Hisaoka K, Kaneko M, Kasai M, Yano R, Okada-Tsuchioka, Morioka N, Takebayashi M, Nakata Y,:
- Organizer
  2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP in Seoul
- Place of Presentation
  Korea
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] うつ病のグリアを介した神経栄養因子・成長因子の役割2011
- Author(s)
  竹林　実
- Organizer
  第54回日本神経化学学会(招待講演)
- Place of Presentation
  加賀市
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Electroconvulsive seizure (ECS) increases thrombospondin-1 (TSP-1) expression in the adult rat hippocampus.2011
- Author(s)
  Okada-Tsuchioka M, Takebayashi M, Segawa-M, Hosoi M, Kajitani N, Shibasaki C, Yano R, Hisaoka K, Morinobu S:
- Organizer
  41th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells: Involvement in glial cell line-derived neurotrophic factor (GDNF) production.2011
- Author(s)
  Hisaoka K, Okada-Tsuchioka M, Yano R, Kajitani N, Morioka N, Nakata Y, Takebayashi M:
- Organizer
  41th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells: Involvement in glial cell line-derived neurotrophic factor (GDNF) production.2011
- Author(s)
  Hisaoka K, Takebayashi M, Okada-Tsuchioka M, Yano R, Kajitani N, Morioka N, Nakata Y,:
- Organizer
  2nd Congress of Asian College of Neuropsychopharmacology Jointly with 2011 Annual Meeting of KCNP in Seoul
- Place of Presentation
  Korea
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] Antidepressants activate expression of fibroblast growth factor receptor (FGFR) signaling in glial cells : Involvement in glial cell line-derived neurotrophic factor (GDNF) production2011
- Author(s)
  Hisaoka K, Okada-Tsuchioka M, Yano R, Kajitani N, Morioka N, Nakata Y, Takebayashi M
- Organizer
  41^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] ECTのバイオマーカーによる評価～近赤外線分光法(NIRS)による試み～2011
- Author(s)
  竹林実
- Organizer
  第24回日本総合病院精神医学会
- Place of Presentation
  福岡
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PLANNED-23118004
[Presentation] 抗うつ薬はラット初代培養アストロサイトにおいてFGF-2の発現を誘導する2011
- Author(s)
  梶谷直人、久岡一恵、葛西美穂、森岡徳光、仲田義啓、竹林実
- Organizer
  第84回日本薬理学会
- Place of Presentation
  東京
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-23591686
[Presentation] リルゾールはグリア細胞において繊維芽細胞増殖因子受容体(FGFR)を介してグリア細胞株由来神経栄養因子(GDNF)を産生する2010
- Author(s)
  土岡麻美、久岡一恵、矢野遼也、梶谷直人、竹林実
- Organizer
  第29回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はグリアにおいてFGF受容体を活性化してGDNFを産生する2010
- Author(s)
  久岡一恵、竹林実、土岡麻美、矢野遼也、梶谷直人、森岡徳光、仲田義啓
- Organizer
  第117回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] グリアに着目した新しいうつ病治療のメカニズム2010
- Author(s)
  竹林実
- Organizer
  第106回日本精神神経学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はラット初代培養アストロサイトにおいてFGF-2の発現を増加させる2010
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、土岡麻美、矢野遼也、竹林実、仲田義啓
- Organizer
  第13回創薬・薬理フォーラム岡山
- Place of Presentation
  広島
- Year and Date
  2010-08-11
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 気分障害のグリア仮説から創薬をめざして2010
- Author(s)
  竹林実
- Organizer
  第32回日本生物学的精神医学会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Antidepressants activate expression of neurotrophic/growth factors in astrocytes.2010
- Author(s)
  Kajitani N, Hisaoka K, Morioka N, Tsuchioka M, Yano R, Nakata Y, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole induces glial cell line-derived neurotrophic factor (GDNF) expression through fibroblast growth factor recerat C6 glioma cells.2010
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajitani N, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole induces glial cell line-derived neurotrophic factor(GDNF)expression through fibroblast growth factor receptor(FGFR)in rat C6 glioma cells.2010
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Shibasaki C, Kajitani N, Takebayashi M
- Organizer
  40^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] ラット初代培養アストロサイトにおいて抗うつ薬が神経栄養因子・成長因子の発現に及ぼす影響2010
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、土岡麻美、朴秀賢、中川伸、仲田義啓、竹林実
- Organizer
  第29回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Antidepressants activate expression of neurotrophic/growth factors in astrocytes.2010
- Author(s)
  Kajitani N, Hisaoka K, Morioka N, Tsuchioka M, Yano R, Nakata Y, Takebayashi M
- Organizer
  40^<th> Meeting of Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants activates FGF receptor signaling in glia : Involvement in GDNF production2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants increase glial cell line-derived neurotrophic factor (GDNF) production through fibroblast growth factorreceptor (FGFR) in glia2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Increased blood levels of neuronal adhesion molecule (NCAM) in remitted patients with mood disorders : a role of glialcell line derived neurotrophic factor (GDNF) signaling2009
- Author(s)
  Takebayashi M
- Organizer
  39^<th> Annual Meeting of Society for Nenroscience
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Altered blood levels of neuronal adhesion molecule (NCAM) in remitted patients with mood disorders : an involvement of glialcell line derived neurotrophic factor (GDNF) signaling2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] ラット初代培養アストロサイトにおいて抗うつ薬はFGF-2の発現を増加させる2009
- Author(s)
  梶谷直人、久岡一恵、森岡徳光、中村明陽、土岡麻美、朴秀賢、中川伸、仲田義啓、竹林実
- Organizer
  第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] グリアにおける抗うつ薬の新規ターゲット分子同定の試み2009
- Author(s)
  土岡麻美、久岡一恵、仲田義啓、竹林実
- Organizer
  第28回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Riluzole rapidly activates a MEK/ERK/CREB pathway in glial cells : a role for GDNF production2009
- Author(s)
  Tsuchioka M, Hisaoka K, Yano R, Takebayashi M
- Organizer
  1st Meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Increased blood levels of neuronal adhesion molecule (NCAM) in remitted patients with mood disorders : a role of glial cell line derived neurotrophic factor (GDNF) signaling.2009
- Author(s)
  Takebayashi M, Hisaoka K, Tsuchioka M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, October
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 難治性うつ病の生物・心理・社会的要因と治療戦略～厚生科学研究費「難治性うつ病研究班」の研究成果から～2009
- Author(s)
  山脇成人、森信繁、岡本泰昌、久住一郎、井上猛、稲垣正俊、三村将、竹林実、中村純、吉村玲児、寺尾岳、小澤寛樹
- Organizer
  第105回日本精神神経学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Anitidepressants increase glial cell line-derived neurotrophic factor (GDNF) production through fibroblast growth factor receptor (FGFR) in glia.2009
- Author(s)
  Hisaoka K, Tsuchioka M, Takebayashi M
- Organizer
  39^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, October
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] 抗うつ薬はFGF受容体を介してグリアからのGDNF産生を誘導する2008
- Author(s)
  久岡一恵、土岡麻美、長島悟史、藤田康孝、竹林実
- Organizer
  第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591384
[Presentation] Serotonin(5-HT) increases glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor 2 (FGFR2) in C6 glioma cells.2008
- Author(s)
  Tsuchioka M, Hisaoka K, Fujita Y, Uike T, Nakata Y, Takebayashi M
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-20591384
[]
[]
[]

1. NAKATA Yoshihiro (40133152)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. HISAOKA Kazue (20393431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. OKADA Mami (30517280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. Kitajima Mika (60305018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 大山要 (50437860)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山口拓 (80325563)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 小川さやか (80629171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 米田哲也 (20305022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 上谷浩之 (80583046)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 朴秀賢 (60455665)

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# of Collaborated Products: 4 results
11. 梶谷直人 (60755742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
12. MIYANO KANAKO (50597888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. HASHIMOTO ERI (30301401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UKAI WATARU (40381256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Kasai Kiyoto (80322056)

# of Collaborated Projects: 1 results

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16. TANAKA Satoshi (00456675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YAMAZAKI Syudo (10447401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MURAI Toshiya (30335286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMAWAKI Shigeto (40230601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OKAMOTO Yasumasa (70314763)

# of Collaborated Projects: 1 results

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21. YAHATA Noriaki (70409150)

# of Collaborated Projects: 1 results

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22. TAKIZAWA Ryu (30420243)

# of Collaborated Projects: 1 results

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23. ISHIGAKI Takuma (70323920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MORINOBU Shigeru (30191042)

# of Collaborated Projects: 1 results

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25. MIYATA Jun (90549099)

# of Collaborated Projects: 1 results

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26. FUKUI Hiroki (40455415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OZAKI Norio (40281480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 上園保仁 (20213340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
29. 西村幸香 (60456738)

# of Collaborated Projects: 1 results

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30. 功刀浩 (40234471)

# of Collaborated Projects: 1 results

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31. 井上飛鳥 (50525813)

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32. 縄田陽子 (00435140)

# of Collaborated Projects: 1 results

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33. 上野雄文 (00441668)

# of Collaborated Projects: 1 results

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34. 福嶋翔 (00727000)

# of Collaborated Projects: 1 results

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35. 植木優夫 (10515860)

# of Collaborated Projects: 1 results

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36. 川尻真也 (20457576)

# of Collaborated Projects: 1 results

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37. 酒井智弥 (30345003)

# of Collaborated Projects: 1 results

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38. 岩永竜一郎 (40305389)

# of Collaborated Projects: 1 results

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39. 曽良一郎 (40322713)

# of Collaborated Projects: 1 results

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40. 今村明 (40325642)

# of Collaborated Projects: 1 results

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41. 小澤寛樹 (50260766)

# of Collaborated Projects: 1 results

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42. 一瀬邦弘 (60437895)

# of Collaborated Projects: 1 results

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43. 中尾理恵子 (80315267)

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47. 可野邦行 (50636404)

# of Collaborated Projects: 1 results

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48. 中嶋幹郎 (00260737)

# of Collaborated Projects: 1 results

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49. 宮元敬天 (20619481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 相原希美 (60908557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. SUGAWARA Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. くぬ刀浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

takebayashi minoru 竹林 実

TAKEBAYASHI Minoru 竹林 実

竹林 実 タケバヤシ ミノル

Research Projects

Research Products

Co-Researchers

革新的高精細MRI画像による神経炎症に着目した高齢者うつ病の病態解明

Principal Investigator

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Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressantsPrincipal Investigator

Principal Investigator

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Challenge to "visualize mental illness" to realize a symbiotic society with illness

Principal Investigator

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海馬アストロサイトに着目した電気けいれん療法の作用機序解明

Principal Investigator

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Review Section

Research Institution

Can we prevent the social penetration of gaming disorder? Basic research for integrated scientific evaluation and early countermeasures against gaming disorder

Principal Investigator

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Review Section

Research Institution

Neuroimaging biomarkers using high-resolution MRI for treatment effect assessment of depression focusing on glia

Principal Investigator

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Research Institution

Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)Principal Investigator

Principal Investigator

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A pharmacological and clinical study of G protein-coupled antidepressant receptors on astrocytesPrincipal Investigator

Principal Investigator

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Identification of novel targets of antidepressant on glia by using pharmacoproteomicsPrincipal Investigator

Principal Investigator

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Integrating molecular and psychosocial approach for assisting adolescent mind development and self-regulation

Principal Investigator

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Review Section

Research Institution

Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in gliaPrincipal Investigator

Principal Investigator

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Research Institution

ニューロステロイドの細胞保護作用および調節メカニズムに関する検討Principal Investigator

Principal Investigator

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Research Institution

[Book] うつ病診療の論理と倫理＜精神医学の基盤＞2015

Author(s)

takebayashi minoru 竹林実

TAKEBAYASHI Minoru 竹林実

竹林実タケバヤシミノル