ITO SHIGEKI 伊藤薫樹

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ITO Shigeki 伊藤薫樹

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Researcher Number	60316362
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015: 岩手医科大学, 医学部腫瘍内科学科, 教授 2014 – 2015: 岩手医科大学, 医学部, 教授 2013: 岩手医科大学, 医学部, 准教授
Review Section/Research Field	Except Principal Investigator Hematology
Keywords	Except Principal Investigator 成熟血小板 / 血小板前駆体 / 巨核球 / 血小板造血 / preplatelet / 血小板産生 / immature platelet / thick protrusion / proplatelet / thrombocytopoiesis / megakaryocyte

Where and how are mature platelets produced?
- Principal Investigator
  
  Ishida Yoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Iwate Medical University

All 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Pharmacokinetics and pharmacodynamics of dasatinib in the chronic phase of newly diagnosed chronic myeloid leukemia.2016
- Author(s)
  Ishida Y, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Ogawa K, Nagashima T, Sato S, Watanabe R, Yamamoto S, Hirose T, Saitou S, Yonezumi M, Kondo T, Kato Y, Mochizuki N, Ohno K, Kishino S, Kubo K, Oyake T, Ito S; Inter-Michinoku Dasatinib Study Group (IMIDAS)
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 72 Issue: 2 Pages: 185-193
- DOI
  10.1007/s00228-015-1968-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461404, KAKENHI-PROJECT-25461458
[Journal Article] Comparison of micafangin and voriconazole as emperic therapies in febrile neutropenia in patients with hematological disorders: a randomized controlled trial.2016
- Author(s)
  Oyake T, Kowata S, Murai K, Ito S, Akagi T, Kubo K, Sawada K, Ishida Y.
- Journal Title
  
  Eur J Haematol
  
  Volume: 96 Issue: 6 Pages: 602-609
- DOI
  10.1111/ejh.12641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09458, KAKENHI-PROJECT-25461458
[Journal Article] A prospective analysis of clinical efficacy and safety in chronic myeloid leukemia-chronic phase patients with imatinib resistance or intolerance as evaluated using European LeukemiaNet 2013 criteria2015
- Author(s)
  2.Murai K, Akagi T, Shimosegawa K, Sugawara T, Ishizawa K, Ito S, Murai K, Motegi M, Yokoyama H, Noji H, Tajima K, Kimura J, Chou T, Ogawa K, Harigae H, Kubo K, Oba K, Sakamoto J, Ishida Y
- Journal Title
  
  Eur J Haematol
  
  Volume: Feb 19 Issue: 6 Pages: 12536-12536
- DOI
  10.1111/ejh.12536
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461577, KAKENHI-PROJECT-25461896, KAKENHI-PROJECT-25461431, KAKENHI-PROJECT-25461458
[Journal Article] YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells2015
- Author(s)
  Sasaki R, Ito S, Asahi M, Ishida Y
- Journal Title
  
  Leuk Res
  
  Volume: 39 Issue: 12 Pages: 1473-1479
- DOI
  10.1016/j.leukres.2015.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014
- Author(s)
  Shugo Kowata, Sumio Isogai, Kazunori Murai, Shigeki Ito, Koujiro Tohyama, Masatsugu Ema, Jiro Hitomi, and Yoji Ishida
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: ?
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes2014
- Author(s)
  Kazunori Murai, Shugo Kowata, Tadashi Shimoyama, Akiko Yashima-Abo, Yukiteru Fujishima, Shigeki Ito, and Yoji Ishida
- Journal Title
  
  Eur J Haematol
  
  Volume: ? Issue: 4 Pages: 290-296
- DOI
  10.1111/ejh.12342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014
- Author(s)
  Kowata S, Isogai S, Murai K, Ito S, Tohyama K, Ema M, Hitomi J and Ishida Y
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 112 Issue: 10 Pages: 743-756
- DOI
  10.1160/th14-02-0123
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] World’s first telepathology experiments　employing　ultra-high-speed internet satellite, nickenemaed “KIZUNA”.2013
- Author(s)
  Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, Kurose A, Osamura YR, Yoshimi N, Kanno H, Moriya T, Ishida Y, Satoh Y, Nakao M, Ogawa E, Matsuo S, Kasai H, Kumagai K, Motoda T, Hopson N
- Journal Title
  
  J Pathol Inform
  
  Volume: 4 Issue: 1 Pages: 24-24
- DOI
  10.4103/2153-3539.119002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23501164, KAKENHI-PROJECT-24590423, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25461458, KAKENHI-PROJECT-25860299, KAKENHI-PROJECT-26670065
[Journal Article] Successful use of cyclophosphamide as an add-on therapy for multiple myeloma patients with acquired resistance to bortezomib or lenalidomide.2013
- Author(s)
  Ito S, Oyake T, Murai K, IshidaY
- Journal Title
  
  Case Rep Hematol
  
  Volume: 65 Pages: 1902-1902
- DOI
  10.1155/2013/651902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells2013
- Author(s)
  Suzuki, Y. Ito, S. Sasaki, R. Asahi, M. Ishida, Y.
- Journal Title
  
  Leuk Res
  
  Volume: 37 Issue: 12 Pages: 1674-79
- DOI
  10.1016/j.leukres.2013.09.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Velocity of Early BCR-ABL Transcript Elimination As an Optimized Predictor of Deep Molecular Response in Chronic Myeloid Leukemia Patients in Chronic Phase on Treatment with Dasatinib2015
- Author(s)
  Kazunori Murai, Kohei Yamaguchi, Shigeki Ito, Tomoaki Akagi, Kazuei Ogawa, Inomata Mitsue, Kuniaki Meguro, Reiko Watanabe, Takuto Miyagishima, Kentaro Wakasa, Motohiro Shindo, Yasuhiko Tsukushi, Kohmei Kubo, Koji Oba, Junichi Sakamoto and Yoji Ishida,
- Organizer
  57th Annual Meeting of America Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Recombinant Thrombomodulin for the Treatment of Transplantation-Associated Coagulopathy after Allogeneic Hematopoietic Stem Cell Transplantation: A Multi-Center Study in Japan2015
- Author(s)
  Kazuyoshi Ishii, Shosaku Nomura, Shinya Fujita, Atushi Satake, Tomoki Ito, Yuta Katayama, Taiichi Kyo, Shuichi Ota, Masanori Seki, Shigeru Chiba, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ikezoe, Hideo Yagi, Kunio Hayashi, Yoji Ishida, Naohito Fujishima, Kenichi Sawada, Masaya Okada, and Hiroyasu Ogawa,
- Organizer
  57th Annual Meeting of America Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Doripenemu versus meropenem as the first-line mono-therapy in high risk febrile neutropenic patients with acute leukemia : A randomized, controlled study2015
- Author(s)
  Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fijishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Platelet Progenitors after Leaving Bone Marrow2015
- Author(s)
  Shugo Kowata, Ryo Togawa, Yoshiaki Okano, Sumio Isogai, Jiro Hitomi, Kazunori Murai, Shigeki Ito, Yoji Ishida,
- Organizer
  57th Annual Meeting of America Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Comparison of micafungin and liposome amphotericin B for empirical anti fungal therapy in febrile neutropenic patients with hematological malignancies: A randomized controlled study2015
- Author(s)
  Fujisawa Y, Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Platelet Progenitors after Leaving Bone Marrow2015
- Author(s)
  Kowata S, Murai K, Oyake T, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Clinical Efficacy and Safety Of Dasatinib For Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase In Japa2013
- Author(s)
  Kohei Yamaguchi, Kazunori Murai, Shigeki Ito, Tomoaki Akagi, , Kazuei Ogawa, Kuniaki Meguro, Mitsue Inomata, Reiko Watanabe, Takuto Miyagishima, Kentaro Wakasa, Motohiro Shindo, Yasuhiko Tsukushi, Kohmei Kubo, and Yoji Ishida
- Organizer
  55th ASH annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Dasatinib Induced Thrombocytopenia Might Be Due To The Inhibition Of Proplatelet Formation Of Megakaryocytes Via The Pathways Including Rho/Rock and Rac2013
- Author(s)
  Kazunori Murai, Shugo Kowata, Yukiteru Fujishima, Yasuhiko Tsukushi, Takahiro Mine, Tatsuo Oyake, Shigeki Ito, and Yoji Ishida
- Organizer
  55th ASH annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Pharmacokinetic (PK) & Pharmacodynamic (PD) analysis of Dasatinib in Chronic Phase of Newly Diagnosed Chronic Myeloid Leukemia (CML-CP)2013
- Author(s)
  Ishida Y, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Ogawa K, Nagashima T, Sato S, Watanabe R, Yamamoto S, Hirose T, Saitou S, Yonezumi M, Kondo K, Kato Y, Mochizuki N, Ohno K, Kishino S, Ito S, Kubo K and Inter-Michinoku Dasatinib Study Group(IMIDAS)
- Organizer
  55th ASH annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] YM155, a Survivin Suppressant, Induces Cell Death Via Suppression Of c-Myc Expression In Multiple Myeloma Cells2013
- Author(s)
  Shigeki Ito, Maki Asahi, Ryousei Sasaki, Tatsuo Oyake, Hideto Tamura, and Yoji Ishida
- Organizer
  55th ASH annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] PLATELET PROGENITORS AFTER LEAVING BONE MARROW
- Author(s)
  Kowata S, Murai K, Oyake T, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] COMPARISON OF MICAFUNGIN AND LIPOSOMAL AMPHOTERICIN B FOR EMPIRICAL ANTIFUNGAL THERAPY IN FEBRILE NEUTROPENIC PATIENTS WITH HEMATOLOGICAL MALIGNANCIES: A RANDOMIZED CONTROLLED TRIAL
- Author(s)
  Fujisawa Y, Tatsuo Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata1 S, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] ndex to Predict MMR at 12 Months in Chronic Phase Chronic Myeloid Leukemia Patients Based on the Area Under the Lymphocyte Curve
- Author(s)
  Murai K, Ito S, Kowata S, Oyake T and Ishida Y,
- Organizer
  56th American Society of Hematology Meeting and Exoosition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] DORIPENEM VERSUS MEROPENEM AS THE FIRST-LINE MONO-THERAPY IN HIGH-RISK FEBRILE NEUTROPENIC PATIENTS WITH ACUTE LEUKEMIA: A RANDOMIZED, CONTROLLED TRIAL
- Author(s)
  Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Dasatinib Is Effective in theTreatment of Mice Models with Immune Thrombocytopenia
- Author(s)
  Shimoyama T, Okano Y, Fujishima Y, Oyake T,Kowata S, Murai K, Ito S, and Ishida Y
- Organizer
  56th American Society of Hematology Meeting and Exoosition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461458

1. Ishida Yoji (70151389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
2. KOWATA Syugo (30418884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. ARIGA Tadashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. OBA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MIURA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 澤井高志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐藤洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 菅野祐幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 黒瀬顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 近藤健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ITO SHIGEKI 伊藤 薫樹

ITO Shigeki 伊藤 薫樹

Research Projects

Research Products

Co-Researchers

Where and how are mature platelets produced?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pharmacokinetics and pharmacodynamics of dasatinib in the chronic phase of newly diagnosed chronic myeloid leukemia.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of micafangin and voriconazole as emperic therapies in febrile neutropenia in patients with hematological disorders: a randomized controlled trial.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A prospective analysis of clinical efficacy and safety in chronic myeloid leukemia-chronic phase patients with imatinib resistance or intolerance as evaluated using European LeukemiaNet 2013 criteria2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014

Author(s)

Journal Title

Data Source

[Journal Article] Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] World’s first telepathology experiments employing ultra-high-speed internet satellite, nickenemaed “KIZUNA”.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful use of cyclophosphamide as an add-on therapy for multiple myeloma patients with acquired resistance to bortezomib or lenalidomide.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Velocity of Early BCR-ABL Transcript Elimination As an Optimized Predictor of Deep Molecular Response in Chronic Myeloid Leukemia Patients in Chronic Phase on Treatment with Dasatinib2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Recombinant Thrombomodulin for the Treatment of Transplantation-Associated Coagulopathy after Allogeneic Hematopoietic Stem Cell Transplantation: A Multi-Center Study in Japan2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Doripenemu versus meropenem as the first-line mono-therapy in high risk febrile neutropenic patients with acute leukemia : A randomized, controlled study2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Platelet Progenitors after Leaving Bone Marrow2015

Author(s)

ITO SHIGEKI 伊藤薫樹

ITO Shigeki 伊藤薫樹

[Journal Article] World’s first telepathology experiments　employing　ultra-high-speed internet satellite, nickenemaed “KIZUNA”.2013