HASEGAWA Kazuhiro 長谷川一浩

… Alternative Names

Researcher Number	60324159
Other IDs
External Links
Affiliation (Current)	2019: 福井大学, 学術研究院医学系部門, 助教
Affiliation (based on the past Project Information) *help	2016 – 2019: 福井大学, 学術研究院医学系部門, 助教 2007 – 2015: University of Fukui, Faculty of Medical Sciences, Assistant Professor 2003 – 2006: 福井大学, 医学部, 助手 2000 – 2002: 福井医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Structural biochemistry / ポストゲノムのナノサイエンス / Biophysics / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Biological Sciences / Experimental pathology / Science and Engineering / Human pathology / Biophysics
Keywords	Principal Investigator アルツハイマー病 / 蛋白質 / 変性とフォールディング / アミロイド線維 / 病理学 / アミロイド / 透析アミロイド症 / 生物物理 / 脳神経疾患 / β2-ミクログロブリン … More Except Principal Investigator β2-ミクログロブリン / アミロイド線維 / アルツハイマー病 / 透析アミロイドーシス / 透析アミロイド症 / アミロイドーシス / βアミロイド線維 / 分子間相互作用 / アミロイド / トランスジェニックマウス / 病理学 / 表面プラズマ共鳴法 / 変性中間体 / 蛋白質 / 抗酸化剤 / ベータアミロイド線維 / アミロイド線維分解 / リゾリン脂質 / Aβ蛋白質 / 細胞毒性 / 血液透析 / シャペロン / 蛋白質品質管理 / 細胞外シャペロン / C反応性蛋白質 / 細胞傷害 / 血清アミロイドP成分 / 透析アミロイド－シス / 表面プラズモン共鳴法 / 重合核依存性重合モデル / 重合速度 / 脱重合速度 / アミロイド線維分解機構 / 原子間力顕微鏡 / 一次反応速度論モデル / チオフラビンT法 / 血管アミロイド症 / アミロイド共存蛋白質 / ベータ2ミクログロブリン / 立体構造変化 / 試験管内形成・分解 / アミロイド共存分子 / 親和性測定 / 体内動態シミュレーション / ポリフェノール化合物 / 線維分解 / ポリフェノール / ビタミンA / 構造活性相関 / 脳神経疾患 / 線維形成・伸長阻害 / フラボノイド / 生体膜模倣環境 / 脂質 / 超音波 / 核形成 / 試験管内分子間相互作用 / トランジェニックマウス / β2ミクログロブリン / β2‐ミクログロブリン / 血清アミロイド成分 / トリフルオロエタノール / グリコサミノグリカン / ドデシル硫酸ナトリウム / リゾフォスファチジン酸 / 陰性荷電 / アミロイド線維形成反応 / 界面活性剤 / Amyloid fibril / Dialysis-related amyloidosis / Beta2-microglobulin / Trifluoroethanol / Glycosamonoglycans / Sodium dodecyl sulfate / Lysophospholipids / Transgenic mouse / 滑膜細胞 / エンドサイトーシス / リソソーム / 滑膜線維芽細胞 Less

生理濃度のnMレベルでのβアミロイド線維形成の検出と分子間相互作用の解析Principal InvestigatorOngoing
- Principal Investigator
  
  長谷川一浩
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  University of Fukui
アミロイドーシス発症の分子機構解明：蛋白質科学・マウスモデル・臨床病理学の融合Ongoing
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
生体を模倣する試験管内アミロイド線維形成反応系の構築と反応機構の解析Principal InvestigatorOngoing
- Principal Investigator
  
  長谷川一浩
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
The mechanism of extracellular protein quality control by extracellular chaperone
- Principal Investigator
  
  Ozawa Daisaku
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposion
- Principal Investigator
  
  Okoshi Tadakazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models
- Principal Investigator
  
  Naiki Hironobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Development of in vitro amyloid fibril formation systems that mimic the physiological fibrillogenesis conditions in vivoPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
The inhibition mechanism of protein aggregation by extracellular chaperone
- Principal Investigator
  
  OZAWA Daisaku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and articular destruction in dialysis related amyloidosis
- Principal Investigator
  
  OOKOSHI Tadakazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
アミロイド線維形成をもたらす生体分子環境および線維沈着による細胞傷害機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Studies on the molecular mechanism of amyloid fibril formation and on the role of extracellular quality control mechanism in the fibril formation.Principal Investigator
- Principal Investigator
  
  HESEGAWA Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
アミロイド線維形成を引き起こす生体内分子環境の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Fukui
Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Kinetic and thermodynamic analysis of the molecular interaction on amyloid fibril formationPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
β2-ミクログロブリンアミロイド線維形成・沈着の分子機構解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
アミロイド線維形成を引き起こす生体内分子環境の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Fukui
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Elucidation of the molecular pathogenesis of dialysis-related amyloidosis.
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
  福井医科大学
Elucidation and control of the molecular mechanism of amyloid fibril formation Applications for nano materialsPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  ポストゲノムのナノサイエンス
- Research Institution
  University of Fukui
  福井医科大学
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
アミロイド線維形成の分子機構
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2003 Other

All Journal Article Presentation

[Journal Article] 老化とアミロイドーシス2018
- Author(s)
  内木宏延, 長谷川一浩, 山口格, 大越忠和, 遠藤芳徳
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 110-115
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.2017
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H.
- Journal Title
  
  Amyloid
  
  Volume: 24(sup1) Pages: 28-29
- DOI
  10.1080/13506129.2017.1295943
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06965
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和，小澤大作，山口格，長谷川一浩，内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.2016
- Author(s)
  Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K.
- Journal Title
  
  Pathology International
  
  Volume: ;66(4) Pages: 193-201
- DOI
  10.1111/pin.12394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和、小澤大作、山口格、長谷川一浩、内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 29077-29077
- DOI
  10.1038/srep29077
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作，大越忠和，長谷川一浩，内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作, 大越忠和, 長谷川一浩, 内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 29 Pages: 199-206
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和, 小澤大作, 山口格, 長谷川一浩, 内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] Endocytosed β2-microglobulin amyloid fibrils induce necrosis and apoptosis of rabbit synovial fibroblasts by disrupting endosomal/lysosomal membranes: A novel mechanism on the cytotoxicity of amyloid fibrils.2015
- Author(s)
  Okoshi, T., Yamaguchi, I., Ozawa, D., Hasegawa, H., Naiki, H.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils2015
- Author(s)
  Okoshi T, Yamaguchi I, Ozawa D, Hasegawa K, Naiki H
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0139330
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06965, KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236
[Journal Article] C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice2015
- Author(s)
  J.Sawashita, B.Zhang, K.Hasegawa, M.Mori, H.Naiki, F.Kametani, K.Higuchi.
- Journal Title
  
  Proc Natl Acad Sci U SA.
  
  Volume: 112
- DOI
  10.1073/pnas.1416363112
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-26293084, KAKENHI-PROJECT-26670152, KAKENHI-PROJECT-25460893
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木宏延，長谷川一浩，小澤大作，大越忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-24570129
[Journal Article] Suface-bound basement membrane components accelerate amyloid-βpeptide nucleation in air-free wells : an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K, Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1834 Pages: 1624-1631
- DOI
  10.1016/j.bbapap.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-24770150, KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K., Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  BiochimBiophys Acta
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Journal Title
  
  The Proceedings of the XIIIth International Symposium on Amyloidosis
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-24770150
[Journal Article] Inhibition of β2-microglobulin amyloid fibril formation by_a2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H.
- Journal Title
  
  J Biol Chem. 286(11)
  
  Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Inhibition of β_2-microglobulin amyloid fibril formation by α_2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2010
- Author(s)
  内木宏延, 長谷川一浩, 小野賢二郎, 山田正仁
- Journal Title
  
  薬学雑誌
  
  Volume: 130(4) Pages: 503-509
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Journal Title
  
  Biochim Biophys Acta. 1804(4)
  
  Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II.2009
- Author(s)
  Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Yasuhara S, Zhang B, Yan J, Mori, M, Naiki H, Higuchi K.
- Journal Title
  
  Biochim Biophys Acta. 1794(10)
  
  Pages: 1517-1529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Growth of β_2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH2008
- Author(s)
  Hasegawa, K., et.al.
- Journal Title
  
  Biochem. J 416
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH.2008
- Author(s)
  Hasegawa K., et al.
- Journal Title
  
  Biochem J. 416(2)
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Growth of β_2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH2008
- Author(s)
  Hasegawa, K., et al.
- Journal Title
  
  Biochem. J. 416
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH2008
- Author(s)
  Hasegawa, K., Tsutsumi-Yasuhara, S., Ookoshi, T., Ohhashi,Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Biochem.J 416(2)
  
  Pages: 307-315
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH.2008
- Author(s)
  Hasegawa K, Tsutsumi-Yasuhara S, Ookoshi T, Ohhashi Y, Kimura H, Takahashi N, Yoshida H, Miyazaki R, Goto Y, Naiki H.
- Journal Title
  
  Biochem J. 416(2)
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Lysophospholipids induce the nucleation and extension of β2-microglobulin-related amyloid fibrils at a neutral pH2008
- Author(s)
  Ookoshi, T. Hasegawa, K., Ohhashi, Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Nephrol. Dial. Transplant 23(10)
  
  Pages: 3247-3255
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure2007
- Author(s)
  Hirohata, M., Hasegawa, K., Tsutsumi-Yasuhara, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., Naiki, H
- Journal Title
  
  Biochemistry 46(7)
  
  Pages: 1888-1899
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
- Author(s)
  Nagai, Y., Inui, T., Popiel, HA., Fujikake, N., Hasegawa, K., Urade, Y., Goto, Y., Naiki, H., Toda, T
- Journal Title
  
  Nat. Struct. Mol. Biol 14(4)
  
  Pages: 332-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Journal Article] The anti-amyloidogenic effect is exerted against Alzheimer's β-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure2007
- Author(s)
  Hirohata, M., Hasegawa, K., Tsutsumi-Yasuhara, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., Naiki, H.
- Journal Title
  
  Biochemistry 46(7)
  
  Pages: 1888-1899
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
- Author(s)
  Nagai, Y., Inui, T., Popiel, H.A., Fujikake, N., Hasegawa, K., Urade, Y., Goto, Y., Naiki, H., Toda, T.
- Journal Title
  
  Nat. Struct. Mol. Biol 14(4)
  
  Pages: 332-340
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] 透析アミロイドーシスとβ2ミクログロブリン2007
- Author(s)
  長谷川一浩, 他
- Journal Title
  
  細胞工学 26
  
  Pages: 156-161
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Journal Article] Amyloidogenic synthetic peptides of β2-microglobulin : a role of the disulfide bond.2003
- Author(s)
  Hasegawa, K. et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 304(1)
  
  Pages: 101-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390123
[Journal Article] Amyloidogenic synthetic peptides of (β2-microglobulin : a role of the disulfide bond.2003
- Author(s)
  Hasegawa, K., et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 304(1)
  
  Pages: 101-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15602001
[Journal Article] Amyloidogenic synthetic peptides of β2-microglobulin : a role of the disulfide bond.2003
- Author(s)
  Hasegawa, K. et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 304(1)
  
  Pages: 101-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390123
[Journal Article] Amyloidogenic synthetic peptides of β2-microglobulin: a role of the disulfide bond.2003
- Author(s)
  Hasegawa, K. et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 304(1)
  
  Pages: 101-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15602001
[Journal Article] Lysophospholipids Induce the Nucleation and Extension of β2-Microglobulin-Related Amyloid Fibrils at a Neutral pH
- Author(s)
  Ookoshi, T., Hasegawa, K., Ohhashi, Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H
- Journal Title
  
  Nephrol. Dial. Transplant (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XV International Symposium on Amyloidosis
- Place of Presentation
  Sweden
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分のアミロイド線維形成抑制および促進効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京）
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場, 福岡市
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K06965
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XVth International Symposium on Amyloidosis
- Place of Presentation
  Uppsala Consert and Congre(Sweden)
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作，野村寮，Mangione P. Patrizia，長谷川一浩，大越忠和，Porcari Riccardo，Bellotti Vittorio，内木宏延
- Organizer
  第１６回日本蛋白質科学会
- Place of Presentation
  福岡県
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] 滑膜線維芽細胞に対するβ2‐ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越忠和、山口格、長谷川一浩、小澤大作、内木宏延
- Organizer
  第2回日本アミロイドーシス研究会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-26860236
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen, the Netherlands (口頭発表およびポスター発表)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation.2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] マウス F 型 apoA-II の C 末ペプチドは老化アミロイドーシス高発症マウスのアミロイド沈着を軽減する2012
- Author(s)
  澤下仁子, 張〓茄, 亀谷富由樹, 長谷川一浩, 森政之, 内木宏延, 樋口京一
- Organizer
  第27回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, NaikiH
- Organizer
  XIII^<th>International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李映昊, 櫻井一正, 柳浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 気液界面の影響を排除したアルツハイマー病βアミロイド線維の核形成検出系の開発2011
- Author(s)
  長谷川一浩, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] 超音波による amyloid β(1-40)の線維形成機構.2011
- Author(s)
  長谷川恭平, 八木寿梓, 志鷹裕司, 内木宏延, 後藤祐児
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 超音波によるamyloid β(1-40)の線維形成機構2011
- Author(s)
  長谷川恭平, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 気液界面の影響を排除したアルツハイマー病βアミロイド線維の核形成検出系の開発2011
- Author(s)
  長谷川一浩, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 気液界面の影響を排除したアルツハイマー病 β アミロイド線維の核形成検出系の開発2011
- Author(s)
  長谷川一浩, 内木宏延
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 超音波によるamyloid β(1-40)の線維形成機構2011
- Author(s)
  長谷川恭平, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Transmissible amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II2010
- Author(s)
  Sawashita J, Kametani F, Hasegawa K, Mori M, Naiki H, Higuchi K
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] ssアミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] a_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D., Hasegawa K., Lee YH., Sakurai K., Yanagi K., Ookoshi T., Goto Y., Naiki H.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara.
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] マウスF型apolipoprotein A-II(apoA-II)のC末アミノ酸配列はアミロイド線維形成を阻止する2010
- Author(s)
  澤下仁子、亀谷富由樹、長谷川一浩、張〓茄、王耀勇、森政之、内木延、樋口京一
- Organizer
  日本基礎老化学会第33回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] β アミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩, 森永章義, 山田正仁, 内木宏延
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] βアミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] ssアミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川浩, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] The role of interfaces and agitation on the fibril formation of amyloid β-protein.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2010
- Place of Presentation
  Hawaii.
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] βアミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩、森永章義、山田正仁、内木宏延
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] 遊離脂肪酸によるβ2-ミクログロブリンアミロイド線維伸長反応促進効果の解析2009
- Author(s)
  大越忠和、長谷川一浩、後藤祐児、内木宏延
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2009
- Author(s)
  内木宏延, 長谷川一浩, 小野賢二郎, 山田正仁
- Organizer
  日本薬学会第129年会シンポジウム(S-22)「アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害 : アルツハイマー病の克服に向けて」
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] 透析アミロイドーシス発症における血漿リゾリン脂質濃度の意義2009
- Author(s)
  高橋直生、木村秀樹、大越忠和、長谷川一浩、奈良雅文、宮崎良一、内木宏延、吉田治義
- Organizer
  第52回平成21年度日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] フラボノイドによるアルツハイマー病βアミロイド線維形成阻害機構2006
- Author(s)
  長谷川一浩, 他
- Organizer
  日本分子イメージング学会設立総会
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する-形態解析を中心に-
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA JW Marriott Down
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils.
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis (USA)
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する－形態解析を中心に－
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25293094

1. NAIKI Hironobu (10227704)

# of Collaborated Projects: 26 results

# of Collaborated Products: 69 results
2. OOKOSHI Tadakazu (90362037)

# of Collaborated Projects: 11 results

# of Collaborated Products: 37 results
3. OZAWA Daisaku (60554524)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
4. HIGUCH Keiichi (20173156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. BAN Tadato (00579667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. GOTO Yuji (40153770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 今野卓 (50225637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAMETANI Kiyokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 亀谷富由樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 森政之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 澤下仁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASEGAWA Kazuhiro 長谷川 一浩

長谷川 一造 ハセガワ カズヒロ

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生理濃度のnMレベルでのβアミロイド線維形成の検出と分子間相互作用の解析Principal InvestigatorOngoing

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アミロイドーシス発症の分子機構解明：蛋白質科学・マウスモデル・臨床病理学の融合Ongoing

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生体を模倣する試験管内アミロイド線維形成反応系の構築と反応機構の解析Principal InvestigatorOngoing

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Development of in vitro amyloid fibril formation systems that mimic the physiological fibrillogenesis conditions in vivoPrincipal Investigator

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Studies on the molecular mechanism of amyloid fibril formation and on the role of extracellular quality control mechanism in the fibril formation.Principal Investigator

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HASEGAWA Kazuhiro 長谷川一浩

長谷川一造ハセガワカズヒロ