NAIKI Hironobu 内木宏延

… Alternative Names

Researcher Number	10227704
Other IDs
External Links
Affiliation (Current)	2020: 福井大学, 学術研究院医学系部門, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 福井大学, 学術研究院医学系部門, 教授 2003 – 2015: Fukui University, Medical School, Professor, 医学部, 教授 1998 – 2002: 福井医科大学, 医学部, 教授 1995 – 1997: 福井医科大学, 医学部, 助教授 1993 – 1994: 福井医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Biological Sciences / Experimental pathology / Experimental pathology / Science and Engineering / 老化(加齢) Except Principal Investigator Structural biochemistry / Biophysics / Radiation science / Human pathology / Experimental pathology … More
Keywords	Principal Investigator アルツハイマー病 / アミロイド線維 / β2-ミクログロブリン / βアミロイド線維 / 透析アミロイド症 / 透析アミロイドーシス / 分子間相互作用 / トランスジェニックマウス / 病理学 / 一次反応速度論モデル … More Except Principal Investigator アミロイドーシス / アルツハイマー病 / アミロイド線維 / 蛋白質 / アミロイド / 透析アミロイドーシス / apoA-II / β2-ミクログロブリン / 変性とフォールディング / シャペロン / マウス / 伝播 / PET / 病理学 / アミロイドβ蛋白 / 脳アミロイドアンギオパチー / 透析アミロイド症 / 生物物理 / 蛍光顕微鏡 / 脳神経疾患 / NMR / 細胞毒性 / 血液透析 / β2ミクログロブリン / 蛋白質品質管理 / β2-microglobulin / amyloid fibril / Amyloid fibril / Dialysis-related amyloidosis / Breast cancer / EMT / ecto-5'-nucleotidase / vimentin / 蛋白構造伝播 / pro-apoA-II / 核形成 / 線維伸長 / アデノウイルスベクター / 分子シャペロン / 蛋白構造 / プリオン / 線維形成 / 構造変換 / 人口血液透析 / 脂質 / 人工血液透析 / タンパク質 / オージェ電子 / 放射線治療 / 分子イメージング / apoA-II,ノックアウトマウス / 熱ショック蛋白質 / リポ蛋白質 / 疾患モデル / HDL / apoA-I / モデル動物 / ノックアウトマウス / SAA / 脳内出血 / MRI / 実験モデル / 天然フェノール化合物 / 脳画像 / 診断マーカー / 試験管内モデル / 動物モデル / 蛋白質の凝集 / 超音波 / アミロイド蛋白質 / 糖尿病 / β2‐ミクログロブリン / タウ蛋白 / タウオリゴマー / 神経細胞死 / ピオグリタゾン / オリゴマー / GSK3β / 透析アミロイド / B_2ミクログロブリン / 一次反応速度論 / AGEs(advanced glycation end products) / fAB_2-m / β_2ミクログロブリン / チオフラビンT / fAβ2-m線維伸長反応 / 一次反応速度論モデル / dialysis amyloidosis / β2-microgulobulin / first-order kinetics / advanced glycation end products / fAβィイD22ィエD2-m / ミスフォールディング / 線維構造 / 環境要因 / アミロイド-シス / in situ hybridization / amyloidosis / mouse / transmission / misfolding / fibril formation / environment / genetics / 蛋白質のフォールディング / 蛋白質の構造安定性 / 水素 / 重水素交換 / アミロイドβペプチド / アミロイド病 / フォールディング / 一分子観察 / Protein folding / Stability of proteins / Fluorescence microscopy / H / D exchange / Amyloid β-peptide / アミロイドβ蛋白(Aβ) / 脳血管障害 / 老化 / 遺伝子多型 / 疫学 / Aβ繊維分解薬 / Aβ線維分解薬 / 高齢者 / 危険因子 / アミロイドβタンパク(Aβ) / cerebral amyloid angiopathy (CAA) / amyloid β protein (Aβ) / Alzheimer's disease / cerebrovascular disorders / aging / geneticpolymorphism / epidemiology / anti-amyloidogenicagents / ナノマテリアル / 合成ペプチド / 蛋白質立体構造変化 / ナノテクノロジー / βアミロイド / 自己組織化 / ドデシル硫酸ナトリウム / βアミロイド線維 / 線維形成制御 / 分子間相互作用 / トリフルオロエタノール / グリコサミノグリカン / beta2-mocroglobulin / nano-material / synthetic peptide / conformational change / nanotechnology / beta amyloid / self-assembly / sinal transduction / 乳癌 / 組織アレイ / ecto 5'-nucleotidase / 免疫染色 / マイクロアレイ / GPI蛋白 / 細胞運動 / integrin β1 / signal transduction / がん / 細胞・組織 / 低酸素 / 酢酸 / 癌 / 腫瘍 / cancer / cell / tissue / hypoxia / acetate / 生体分子 / Biophysics / Biological molecules / Alzheimaer's disease / 滑膜細胞 / エンドサイトーシス / リソソーム / 滑膜線維芽細胞 / 細胞傷害 / 実験病理学 Less

生理濃度のnMレベルでのβアミロイド線維形成の検出と分子間相互作用の解析Ongoing
- Principal Investigator
  
  長谷川一浩
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  University of Fukui
β2-ミクログロブリンアミロイド線維による細胞傷害機構、及び細胞刺激作用の解析
- Principal Investigator
  
  大越忠和
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
アミロイドーシス発症の分子機構解明：蛋白質科学・マウスモデル・臨床病理学の融合Principal InvestigatorOngoing
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Development of in vitro amyloid fibril formation systems that mimic the physiological fibrillogenesis conditions in vivo and their application to the analysis of fibril formation mechanism
- Principal Investigator
  
  Hasegawa Kazuhiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
The mechanism of extracellular protein quality control by extracellular chaperone
- Principal Investigator
  
  Ozawa Daisaku
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposion
- Principal Investigator
  
  Okoshi Tadakazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal modelsPrincipal Investigator
- Principal Investigator
  
  Naiki Hironobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Molecular mechanisms of Alzheimer's disease induced by oligomeric tau protein.
- Principal Investigator
  
  HAMANO TADANORI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Fukui
Development of in vitro amyloid fibril formation systems that mimic the physiological fibrillogenesis conditions in vivo
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
The inhibition mechanism of protein aggregation by extracellular chaperone
- Principal Investigator
  
  OZAWA Daisaku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and articular destruction in dialysis related amyloidosis
- Principal Investigator
  
  OOKOSHI Tadakazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse modelPrincipal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Understanding the mechanism of amyloid fibrillation on the basis of single fibril and real-time observation
- Principal Investigator
  
  GOTO Yuji)
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
アミロイド線維形成をもたらす生体分子環境および線維沈着による細胞傷害機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Systemic analysis of amyloidosis using animal models
- Principal Investigator
  
  HIGUCHI Keiichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shinshu University
Development of risk assessment and prevention of cerebral amyloid angiopathy-related cerebral hemorrhages
- Principal Investigator
  
  YAMADA Masahito
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa University
Studies on the molecular mechanism of amyloid fibril formation and on the role of extracellular quality control mechanism in the fibril formation.
- Principal Investigator
  
  HESEGAWA Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui
オージェ電子放出ハロゲンを利用したアルツハイマー病の新しい治療法の開発
- Principal Investigator
  
  清野泰
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  University of Fukui
アミロイド線維形成を引き起こす生体内分子環境の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Fukui
Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-Principal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
リゾリン脂質によるβ2-ミクログロブリンアミロイド線維の伸長促進効果
- Principal Investigator
  
  大越忠和
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  University of Fukui
Kinetic and thermodynamic analysis of the molecular interaction on amyloid fibril formation
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
β2-ミクログロブリンアミロイド線維形成・沈着の分子機構解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Basic Studies on Biochemical and Molecular Biological Diagnosis of Tumor Hypoxia by PET
- Principal Investigator
  
  FURUKAWA Takako
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
  University of Fukui
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
アミロイド線維形成を引き起こす生体内分子環境の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Fukui
Association between Ecto-5'-nucleotidase and Vimentin in Aggressive Breast Cancer Cells
- Principal Investigator
  
  INAI Kunihiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Elucidation of the molecular pathogenesis of dialysis-related amyloidosis.Principal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
  福井医科大学
Elucidation and control of the molecular mechanism of amyloid fibril formation Applications for nano materials
- Principal Investigator
  
  HASEGAWA Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  ポストゲノムのナノサイエンス
- Research Institution
  University of Fukui
  福井医科大学
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
アミロイド線維形成の分子機構Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Study on molecular pathogenesis and therapies for cerebral amyloid angiopathy
- Principal Investigator
  
  YAMADA Masahito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa University
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Understanding the amyloid fibril formation of β2-microglobulin on the basis of protein conformation
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
アルツハイマー病βアミロイド線維の試験管内形成及び分解機構の解明Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Analysis of the mechanism of misfolding to amyloid protein using mouse amyloidosis
- Principal Investigator
  
  HIGUCHI Keiichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
アミロイド蛋白(apoA-II)の線維構造への変換を制御する分子シャペロン
- Principal Investigator
  
  樋口京一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Shinshu University
Studies on the inhibitory mechanism of biological molecules and antioxidants for Alzheimer's β-amyloid fibril formation.Principal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  FUKUI MEDICAL UNIVERSITY
Studies on dialysis-related amyloid fibril formation by a in vitro kinetic model
- Principal Investigator
  
  GEJYO Fumitake
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
  福井医科大学
マウスアミロイド蛋白(apoA-II)の構造交換と分子シャペロン
- Principal Investigator
  
  HIGUCH Keiichi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro.Principal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Fukui Medical University
アルツハイマー病βアミロイド線維重合の反応速度論的解析Principal Investigator
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  福井医科大学
Effect of Pathogen Status on the Manifestation of Accelerated Senescence and Murine Senile Amyloidosis in Senescence Accelerated Mouse (SAM)Principal Investigator
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Fukui Medical School

[Book] 多発性骨髄腫Updating　第６巻：ALアミロイドーシス、多発性骨髄腫の類縁疾患2014
- Author(s)
  清水　一之, 安倍　正博, 島崎　千尋, 鈴木　憲史, 張　高明, 加藤　修明, 関島　良樹, 内木　宏延　他
- Total Pages
  296
- Publisher
  株式会社　医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-25293094
[Book] 変革する透析医学（透析アミロイドーシスの病態）2012
- Author(s)
  小澤大作，風間順一郎，内木宏延
- Total Pages
  5
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24770150
[Book] タンパク質の事典2008
- Author(s)
  内木宏延
- Total Pages
  863
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-18390120
[Book] タンパク質の事典(編 : 猪飼篤, 伏見譲, 卜部格, 上野川修一, 中村春木, 浜窪隆雄),"アミロイドタンパク質"2008
- Author(s)
  内木宏延(分担執筆)
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-18390120
[Book] ルービン病理学-臨床医学への基盤2007
- Author(s)
  内木宏延, 他
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-18659249
[Journal Article] Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy.2019
- Author(s)
  Endo Yoshinori、Hasegawa Kazuhiro、Nomura Ryo、Arishima Hidetaka、Kikuta Ken-ichiro、Yamashita Taro、Inoue Yasuteru、Ueda Mitsuharu、Ando Yukio、Wilson Mark R.、Hamano Tadanori、Nakamoto Yasunari、Naiki Hironobu
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 7 Pages: 12-12
- DOI
  10.1186/s40478-019-0662-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07502, KAKENHI-PROJECT-15H04841, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-17H06972, KAKENHI-PROJECT-16K09235
[Journal Article] Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice2018
- Author(s)
  Kawasaki A, Ito N, Murai H, Yasutomi M, Naiki H, Ohshima Y
- Journal Title
  
  Allergy
  
  Volume: 印刷中 Pages: 1313-1321
- DOI
  10.1111/all.13404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-16K19633, KAKENHI-PROJECT-16K10018
[Journal Article] 老化とアミロイドーシス2018
- Author(s)
  内木宏延, 長谷川一浩, 山口格, 大越忠和, 遠藤芳徳
- Journal Title
  
  病理と臨床
  
  Volume: 36 Pages: 110-115
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] Pathological examination of cerebral amyloid angiopathy in patients who underwent removal of lobar hemorrhages.2018
- Author(s)
  Lin CM, Arishima H, Kikuta KI, Naiki H, Kitai R, Kodera T, Matsuda K, Hashimoto N, Isozaki M, Tsunetoshi K, Neishi H, Higashino Y, Akazawa A, Arai H, Yamada S
- Journal Title
  
  J Neurol
  
  Volume: 265 Pages: 567-577
- DOI
  10.1007/s00415-018-8740-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10713, KAKENHI-PROJECT-16H05170
[Journal Article] Aggregation-phase diagrams of β2-microglobulin reveal temperature and salt effects on competitive formation of amyloids versus amorphous aggregates.2018
- Author(s)
  Masayuki Adachi, Masahiro Noji, Masatomo So, Kenji Sasahara, Jozsef Kardos, Hironobu Naiki, Yuji Goto
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Pages: 14775-14785
- DOI
  10.1074/jbc.ra118.004683
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07363, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-17K15074
[Journal Article] Heparin-induced amyloid fibrillation of β2-microglobulin explained by solubility and a supersaturation-dependent conformational phase diagram.2017
- Author(s)
  So, M., Hata, Y., Naiki, H. and Goto, Y.
- Journal Title
  
  Protein Sci
  
  Volume: 26 Pages: 1024-1036
- DOI
  10.1002/pro.3149
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00836, KAKENHI-PROJECT-15H04362, KAKENHI-PROJECT-15K14458, KAKENHI-PROJECT-16H05170
[Journal Article] Tubulointerstitial nephritis with IgM-positive plasma cells.2017
- Author(s)
  Takahashi N,　Kimura H et al
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 28 Pages: 3688-3698
- DOI
  10.1681/asn.2016101074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08931, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-17K09692, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-15H04836, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K09252
[Journal Article] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.2017
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H.
- Journal Title
  
  Amyloid
  
  Volume: 24(sup1) Pages: 28-29
- DOI
  10.1080/13506129.2017.1295943
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06965
[Journal Article] Treatment with geranylgeranylacetone induces heat shock protein 70 and attenuates neonatal hyperoxic lung injury in a model of bronchopulmonary dysplasia.2017
- Author(s)
  Shuko Tokuriki, Aiko Igarashi, Takashi Okuno, Genrei Ohta, Hironobu Naiki, Yusei Ohshima
- Journal Title
  
  Lung
  
  Volume: - Pages: 28447205-28447205
- DOI
  10.1007/s00408-017-0007-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870229, KAKENHI-PROJECT-16H05170
[Journal Article] アミロイド線維の形成・沈着と臓器障害の分子機構2016
- Author(s)
  大越忠和, 内木宏延
- Journal Title
  
  医学のあゆみ
  
  Volume: 258 Pages: 615-620
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作，大越忠和，長谷川一浩，内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] Significant association of cadaveric dura mater grafting with subpial Abeta deposition and meningeal amyloid angiopathy.2016
- Author(s)
  Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M
- Journal Title
  
  Acta Neuropathol
  
  Volume: 132(2) Pages: 313-315
- DOI
  10.1007/s00401-016-1588-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26860234, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-16H06277
[Journal Article] Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.2016
- Author(s)
  Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K.
- Journal Title
  
  Pathology International
  
  Volume: ;66(4) Pages: 193-201
- DOI
  10.1111/pin.12394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和、小澤大作、山口格、長谷川一浩、内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和，小澤大作，山口格，長谷川一浩，内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] アミロイド線維の形成、沈着と臓器障害の分子機構2016
- Author(s)
  大越忠和、内木宏延
- Journal Title
  
  医学のあゆみ
  
  Volume: 258
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和, 小澤大作, 山口格, 長谷川一浩, 内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 29077-29077
- DOI
  10.1038/srep29077
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作, 大越忠和, 長谷川一浩, 内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 29 Pages: 199-206
- Data Source
  KAKENHI-PROJECT-16H05170
[Journal Article] HBME-1 and CD15 immunocytochemistry in the follicular variant of thyroid papillary carcinoma.2015
- Author(s)
  Ohta, M., Ookoshi, T., Naiki, H., Imamura, Y.
- Journal Title
  
  Pathol Int.
  
  Volume: 65 Pages: 119-125
- DOI
  10.1111/pin.12252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Supersaturation-limited and unlimited phase spaces compete to produce maximal amyloid fibrillation near the critical micelle concentration of sodium dodecyl sulfate.2015
- Author(s)
  So, M., Ishii, A., Hata, Y., Yagi, H., Naiki, H. and Goto, Y.
- Journal Title
  
  Langmuir
  
  Volume: 31(36) Pages: 9973-9982
- DOI
  10.1021/acs.langmuir.5b02186
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04362, KAKENHI-PROJECT-25293094
[Journal Article] C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice2015
- Author(s)
  J.Sawashita, B.Zhang, K.Hasegawa, M.Mori, H.Naiki, F.Kametani, K.Higuchi.
- Journal Title
  
  Proc Natl Acad Sci U SA.
  
  Volume: 112
- DOI
  10.1073/pnas.1416363112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-26293084, KAKENHI-PROJECT-26670152, KAKENHI-PROJECT-25460893
[Journal Article] Kodera T, Arishima H, Kitai R, Kikuta K, Iino S, Noriki S, Naiki H.2015
- Author(s)
  Kodera T, Arishima H, Kitai R, Kikuta K, Iino S, Noriki S, Naiki H.
- Journal Title
  
  Neurosurg. Rev.
  
  Volume: 38 Pages: 165-170
- DOI
  10.1007/s10143-014-0574-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590250, KAKENHI-PLANNED-26108009, KAKENHI-PROJECT-15K08150, KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-26670348, KAKENHI-PROJECT-25293094
[Journal Article] Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils2015
- Author(s)
  Okoshi T, Yamaguchi I, Ozawa D, Hasegawa K, Naiki H
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0139330
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06965, KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236
[Journal Article] A heterozygous female with Fabry disease due to a novel alpha-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes2015
- Author(s)
  Takahashi N, Yokoi S, Kasuno K, Kogami A, Tsukimura T, Togawa T, Saito S, Ohno K, Hara M, Kurosawa H, Hirayama Y, Kurose T, Yokoyama Y, Mikami D, Kimura H, Naiki H, Sakuraba H, Iwano M.
- Journal Title
  
  Clin. Nephrol.
  
  Volume: 83 Pages: 301-308
- DOI
  10.5414/cn108317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590686, KAKENHI-PROJECT-25860399, KAKENHI-PROJECT-25293094
[Journal Article] Endocytosed β2-microglobulin amyloid fibrils induce necrosis and apoptosis of rabbit synovial fibroblasts by disrupting endosomal/lysosomal membranes: A novel mechanism on the cytotoxicity of amyloid fibrils.2015
- Author(s)
  Okoshi, T., Yamaguchi, I., Ozawa, D., Hasegawa, H., Naiki, H.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-24570129
[Journal Article] Heat of Supersaturation-limited Amyloid Burst Directly Monitored by Isothermal Titration Calorimetry2014
- Author(s)
  Ikenoue, T., Lee, Y.-H., Kardos, J., Yagi, H., Ikegami, T., Naiki, H. and Goto, Y.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111 Pages: 6654-6659
- DOI
  10.1073/pnas.1322602111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24370067, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-25870407
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木宏延，長谷川一浩，小澤大作，大越忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry.2014
- Author(s)
  Ikenoue T, Lee YH, Kardos J, Yagi H, Ikegami T, Naiki H, Goto Y.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K., Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  BiochimBiophys Acta
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] 腎アミロイドーシスの診断と線維形成機序2013
- Author(s)
  高橋　直生, 岩野　正之, 内木　宏延, 木村　秀樹
- Journal Title
  
  Nephrolgy Frontier
  
  Volume: 12 (1)
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Suface-bound basement membrane components accelerate amyloid-βpeptide nucleation in air-free wells : an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K, Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1834 Pages: 1624-1631
- DOI
  10.1016/j.bbapap.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-24770150, KAKENHI-PROJECT-25293094
[Journal Article] Cerebral amyloid angiopathy2012
- Author(s)
  Yamada M, Naiki H
- Journal Title
  
  Prog Mol Biol Transl Sci
  
  Volume: 107 Pages: 41-78
- DOI
  10.1016/b978-0-12-385883-2.00006-0
- NAID
  40020153825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390242
[Journal Article] Cerebral amyloid angiopathy2012
- Author(s)
  Yamada M, Naiki H
- Journal Title
  
  Prog Mol Biol Transl Sci
  
  Volume: 107 Pages: 41-78
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation2012
- Author(s)
  Yoshimura Y, Lin Y, Yagi H, Lee YH, Kitayama H, Sakurai K, So M, Ogi H, Naiki H, Goto Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109(36) Pages: 14446-14451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Journal Title
  
  The Proceedings of the XIIIth International Symposium on Amyloidosis
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-24770150
[Journal Article] Polymorphism of β_2-microglobulin amyloidfibrils manifested by ultrasonication-enhanced fibril formation in trifluoroethanol.2012
- Author(s)
  Chatani E, Yagi H, Naiki H, Goto Y
- Journal Title
  
  J Biol Chem
  
  Volume: 287(27) Pages: 22827-22837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques2012
- Author(s)
  Yanagi K, Sakurai K, Yoshimura Y, Konuma T, Lee YH, Sugase K, Ikegami T, Naiki H, Goto Y
- Journal Title
  
  J Mol Biol
  
  Volume: 422(3) Pages: 390-402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] アミロイドーシス2011
- Author(s)
  高橋直生, 木村秀樹, 吉田治義, 内木宏延
- Journal Title
  
  日内会誌
  
  Volume: 100(5) Pages: 1282-1288
- NAID
  10029097141
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Reversible heat-induced dissociation of β_2-microglobulin amyloid fibrils.2011
- Author(s)
  Kardos J, Micsonai A, Pal-Gabor H, Petrik e, Graf L, Kovacs J, Lee YH, Naiki H, Goto Y
- Journal Title
  
  Biochemistry
  
  Volume: 50(15) Pages: 3211-3220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Kinetic intermediates ofβ2-microglobulin fibril elongation probed by pulse-labeling H/ D exchange combined with NMR analysis2011
- Author(s)
  Konuma, T., Chatani, E., Yagi, M., Sakurai, K., Ikegami, T., Naiki, H. & Goto, Y.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 405 Pages: 851-862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin2011
- Author(s)
  T. Ozawa, D., Kaji, Y., Yagi, H., Sakurai, K., Kawakami, T., Naiki, N. & Goto, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 10856-10863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Inhibition of β2-microglobulin amyloid fibril formation by_a2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H.
- Journal Title
  
  J Biol Chem. 286(11)
  
  Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Reversible heat-induced dissociation ofβ2-microglobulin amyloid fibrils2011
- Author(s)
  Kardos, J., Micsonai, A., Pa. l-Ga. bor, H., Petrik, E., Gra. f, L., Kova. cs, J., Lee, Y. H., Naiki, H. & Goto, Y.
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 3211-3220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Inhibition of β_2-microglobulin amyloid fibril formation by α_2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Ultrasonication-dependent acceleration of amyloid fibril formation2011
- Author(s)
  So, M., Yagi, H., Sakurai, K., Ogi, H., Naiki, H. & Goto, Y.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 412 Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Inhibition of. 2-microglobulin amyloid fibril formation byα2-macroglobulin2011
- Author(s)
  Ozawa, D., Hasegawa, K., Lee, Y. H., Sakurai, K., Yanagi, K., Ookoshi, T., Goto, Y., Naiki, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Ultrasonication-dependent acceleration of amyloid fibril formation2011
- Author(s)
  So M, Yagi H, Sakurai K, Ogi H, Naiki H, Goto Y .
- Journal Title
  
  J Mol Biol
  
  Volume: 412(4) Pages: 568-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Kinetic intermediates of β_2-microglobulin fibril elongation probed by pulse-labeling H/D exchange combined with NMR analysis2011
- Author(s)
  Konuma T, Chatani E, Yagi M, Sakurai K, Ikegami T, Naiki H, Goto Y
- Journal Title
  
  J Mol Biol
  
  Volume: 405(3) Pages: 851-862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin2011
- Author(s)
  Ozawa D, Kaji Y, Yagi H, Sakurai K Kawakami T, Naiki H, Goto Y
- Journal Title
  
  T. J Biol Chem
  
  Volume: 286(12) Pages: 10856-10863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2010
- Author(s)
  内木宏延, 他
- Journal Title
  
  薬学雑誌
  
  Volume: 130 Pages: 503-509
- NAID
  130000259538
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Critical role of interfaces and agitation on the nucleation of Aβamyloid fibrils at low concentrations of Aβmonomers2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H
- Journal Title
  
  Biochem Biophys Acta-Proteins and Proteomics
  
  Volume: 1804 Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390242
[Journal Article] Pre-steady-state kinetic analysis of the elongation of amyloid fibrils of β_2-microglobulin with tryptophan mutagenesis2010
- Author(s)
  Chatani E, Ohnishi R, Konuma T, Sakurai K, Naiki H, Goto Y
- Journal Title
  
  J Mol Biol
  
  Volume: 400(5) Pages: 1057-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy2010
- Author(s)
  Yoshimura Y, Sakurai K, Lee YH, Ikegami T, Chatani E, Naiki H, Goto Y
- Journal Title
  
  Protein Sci
  
  Volume: 19(12) Pages: 2347-2355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Mouse model to study human Aβ32M amyloidosis : Generation of a transgenic mouse with excessive expression of human β32-microglobulin.2010
- Author(s)
  Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K
- Journal Title
  
  Amyloid 17
  
  Pages: 50-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300144
[Journal Article] Pre-steady state kinetic analysis for the elongation of amyloid fibrils ofβ2-microglobulin with tryptophan mutagenesis2010
- Author(s)
  Chatani, E., Ohnishi1, R., Konuma, T., Sakurai, K., Naiki, N. & Goto, Y.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 400 Pages: 1057-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Critical role of interfaces and agitation on the nucleation of Aβ amyloid fibrils at low concentrations of Aβ monomers.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Journal Title
  
  Biochem Biophys Acta - Proteins and Proteomics 1804
  
  Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390242
[Journal Article] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2010
- Author(s)
  内木宏延, 他
- Journal Title
  
  薬学雑誌
  
  Volume: 130 Pages: 503-509
- NAID
  130000259538
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] The amyloid fibrils of the constant domain of immunoglobulin light chain2010
- Author(s)
  Yamamoto K, Yagi H, Lee YH, Kardos J, Hagihara Y, Naiki H, Goto Y
- Journal Title
  
  FEBS Lett
  
  Volume: 584(15) Pages: 3348-3353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Mouse model to study human Aβ_2M amyloidosis: generation of a transgenic mouse with excessive expression of human β_2-microglobulin2010
- Author(s)
  Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K
- Journal Title
  
  Amyloid
  
  Volume: 17(2) Pages: 50-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2010
- Author(s)
  内木宏延, 長谷川一浩, 小野賢二郎, 山田正仁
- Journal Title
  
  薬学雑誌
  
  Volume: 130(4) Pages: 503-509
- NAID
  130000259538
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Amyloid fibrils of the constant domain of immunoglobulin light chain2010
- Author(s)
  Yamamoto, K., Yagi, H., Lee, Y. H., Kardos, K., Hagihara, Y., Naiki, H. & Goto, Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 3348-3353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy2010
- Author(s)
  Yoshimura, Y., Sakurai, K., Lee, Y.-H., Ikegami, T., Chatani, E., Naiki, H. & Goto, Y.
- Journal Title
  
  Protein Sci.
  
  Volume: 19 Pages: 2347-2355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Laser-induced propagation and destruction of amyloid β fibrils2010
- Author(s)
  Yagi H, Ozawa D, Sakurai K, Kawakami T, Kuyama H, Nishimura O, Shimanouchi T, Kuboi R, Naiki H, Goto Y
- Journal Title
  
  J Biol Chem
  
  Volume: 285(25) Pages: 19660-19667
- NAID
  120006557646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2010
- Author(s)
  内木宏延, 他
- Journal Title
  
  薬学雑誌
  
  Volume: 130 Pages: 503-509
- NAID
  130000259538
- Data Source
  KAKENHI-PUBLICLY-22020014
[Journal Article] Critical role of interfaces and agitation on the nucleation of Aβ amyloid fibrils at low concentrations of Aβ monomers2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H
- Journal Title
  
  Biochem Biophys Acta-Proteins and Proteomics 1804
  
  Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390242
[Journal Article] Laser-induced propagation and destruction of amyloidβfibrils2010
- Author(s)
  Yagi, H., Ozawa, D., Sakurai, K., Kawakami, T., Kuyama, H., Nishimura, O., Shimanouchi, T., Kuboi, R., Naiki, H. & Goto, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 19660-19667
- NAID
  120006557646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] 透析アミロイドーシス発症の分子機構2010
- Author(s)
  内木宏延
- Journal Title
  
  医学のあゆみ
  
  Volume: 別册 Pages: 75-81
- Data Source
  KAKENHI-PUBLICLY-22020014
[Journal Article] Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Journal Title
  
  Biochim Biophys Acta. 1804(4)
  
  Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] 透析アミロイドーシス発症の分子機構2010
- Author(s)
  内木宏延
- Journal Title
  
  医学のあゆみ
  
  Pages: 75-81
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II.2009
- Author(s)
  Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Yasuhara S, Zhang B, Yan J, Mori, M, Naiki H, Higuchi K.
- Journal Title
  
  Biochim Biophys Acta. 1794(10)
  
  Pages: 1517-1529
- NAID
  120002598959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] NMR-based characterization of a refolding intermediate ofβ2-microglobulin labeled amino acid selectively using a wheat germ cell-free system2009
- Author(s)
  Kameda, A., Morita, E.-H., Sakurai, K., Naiki, N. & Goto, Y.
- Journal Title
  
  Protein Sci.
  
  Volume: 18 Pages: 1592-1601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Destruction of amyloid fibrils of a β2-microgobulin fragment by laser beam irradiation2009
- Author(s)
  Ozawa, D., Yagi, H., Ban, T.Kameda, A., Kawakami,T., Naiki, H., Goto, Y.
- Journal Title
  
  J. Biol. Chem 284(2)
  
  Pages: 1009-1017
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Thermal response with exothermic effects of. 2-microglobulin amyloid fibrils and fibrillation2009
- Author(s)
  Sasahara, K., Yagi, H., Naiki, H. & Goto, Y.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 389 Pages: 584-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] 透析アミロイドーシス発症の分子機構2009
- Author(s)
  内木宏延
- Journal Title
  
  医学のあゆみ 229
  
  Pages: 377-383
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] Destruction of amyloid fibrils of aβ2-microglobulin fragment by laser beam irradiation2009
- Author(s)
  Ozawa, D., Yagi, H., Ban, T., Kameda, A., Kawakami, T., Naiki, H., & Goto, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 1009-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Ultrasonication establishes the equilibrium between production and breakdown leading to the minimum-sized amyloid fibrils2009
- Author(s)
  Chatani, E., Lee, Y.-H., Yagi, H., Yoshimura, Y., Naiki, N. & Goto, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 106 Pages: 11119-11124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II.2009
- Author(s)
  Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Y S, Zhang B, Yan J, Mori M, Naiki H, Higuchi K
- Journal Title
  
  Biochim Biophys Acta-Proteins & Proteomics 1794
  
  Pages: 1517-1529
- NAID
  120002598959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300144
[Journal Article] A comprehensive model for packing and hydration for amyloid fibrils of. 2-microglobulin2009
- Author(s)
  Lee, Y.-H., Chatani, E., Sasahara, K., Naiki, H. & Goto, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 2169-2175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370044
[Journal Article] アミロイド線維の形成・沈着機構-重合核依存性重合モデルを中心に-2009
- Author(s)
  内木宏延, 他
- Journal Title
  
  神経内科 70
  
  Pages: 129-135
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] A comprehensive model for packing and hydration for amyloid fibrils of β2-microglobulin2009
- Author(s)
  Lee, Y-H., Chatani, E., Sasahara, K., Naiki, H., Goto, Y.
- Journal Title
  
  J. Biol. Chem 284(4)
  
  Pages: 2169-2175
- NAID
  120006557647
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Molecular pathogenesis of protein misfolding diseases : pathological molecular environments versus quality control systems against misfolded proteins2009
- Author(s)
  Naiki, H., et al.
- Journal Title
  
  J.Biochem. 146
  
  Pages: 751-756
- NAID
  10026304899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] アミロイドーシス2009
- Author(s)
  内木宏延
- Journal Title
  
  病理と臨床 27
  
  Pages: 273-279
- NAID
  10029097141
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] アミロイド線維の形成・沈着機構-重合核依存性重合モデルを中心に-2009
- Author(s)
  内木宏延, 他
- Journal Title
  
  神経内科 70
  
  Pages: 129-135
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] Procollagen C-proteinase enhancer-1(PCPE-1)interacts with β2-microglobulin(β2-m)and may help initiate β2-m amyloid fibril formation in connective tissues2008
- Author(s)
  Morimoto, H., Wada, J., Font, B., Mott, J.D., Hulmes D.J., Ookoshi, T., Naiki, H., Yasuhara, A., Nakatsuka, A., Fukuoka, K., Takatori, Y., Ichikawa, H., Akagi, S., Nakao, K., Makino, H.
- Journal Title
  
  Matrix Biol 27(3)
  
  Pages: 211-219
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH2008
- Author(s)
  Hasegawa, K., Tsutsumi-Yasuhara, S., Ookoshi, T., Ohhashi,Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Biochem.J 416(2)
  
  Pages: 307-315
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] チオフラビンT2008
- Author(s)
  内木宏延
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages: 968-968
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] アミロイド2008
- Author(s)
  内木宏延
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages: 906-906
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Lysophospholipids induce the nucleation and extension of β2-microglobulin-related amyloid fibrils at a neutral pH2008
- Author(s)
  Ookoshi, T. Hasegawa, K., Ohhashi, Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H.
- Journal Title
  
  Nephrol. Dial. Transplant 23(10)
  
  Pages: 3247-3255
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Growth of β2-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH.2008
- Author(s)
  Hasegawa K, Tsutsumi-Yasuhara S, Ookoshi T, Ohhashi Y, Kimura H, Takahashi N, Yoshida H, Miyazaki R, Goto Y, Naiki H.
- Journal Title
  
  Biochem J. 416(2)
  
  Pages: 307-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] アルロイド2008
- Author(s)
  内木宏延
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages: 906-906
- Data Source
  KAKENHI-PROJECT-20059015
[Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
- Author(s)
  Nagai, Y., Inui, T., Popiel, HA., Fujikake, N., Hasegawa, K., Urade, Y., Goto, Y., Naiki, H., Toda, T
- Journal Title
  
  Nat. Struct. Mol. Biol 14(4)
  
  Pages: 332-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Journal Article] Inhibitors of amyloid β-protein aggregation mediated by GM1-containing raft-like membranes2007
- Author(s)
  Matsuzaki, K., Noguch, T., Wakabayashi, M., Ikeda, K., Okada, T., Ohashi, Y., Hoshino, M., Naiki, H.
- Journal Title
  
  Biochim. Biophys. Acta-Biomembranes 1768(1)
  
  Pages: 122-130
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils and protein A amyloid fibrils2007
- Author(s)
  Yan, J., Fu, X., Ge, F., Zhang, B., Yao, J., Zhang, H., Qian, J., Tomozawa, H., Naiki, H., Sawashita, J., Mori, M., Higuchi, K.
- Journal Title
  
  Am.J.Pathol 171(1)
  
  Pages: 172-180
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] 透析アミロイドーシス-基礎研究から治療戦略Update-2007
- Author(s)
  内木宏延, 他
- Journal Title
  
  透析会誌 40
  
  Pages: 1025-1025
- Data Source
  KAKENHI-PROJECT-18031014
[Journal Article] The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure2007
- Author(s)
  Hirohata, M., Hasegawa, K., Tsutsumi-Yasuhara, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., Naiki, H
- Journal Title
  
  Biochemistry 46(7)
  
  Pages: 1888-1899
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Journal Article] 透析アミロイドーシス-基礎研究から治療戦略Update-2007
- Author(s)
  内木宏延, 他
- Journal Title
  
  透析会誌 40
  
  Pages: 1025-1025
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Visualization and classification of amyloid β supramolecular assemblies2007
- Author(s)
  Yagi, H., Ban, T. Morigaki, K., Naiki, H., Goto, Y.
- Journal Title
  
  Biochemistry 46(51)
  
  Pages: 15009-15017
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Frequent Detection of Multi-drug Resistant Pneumonia-causing Bacteria in the Lung Tissues of Patients with Hematological Malignancies2007
- Author(s)
  Inai K, Iwasaki H, Noriki S, Ikegaya S, Yamashita M, Imamura Y, Takimoto N, Kato H, Ueda T, Naiki H.
- Journal Title
  
  Int. J. Hematol.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590306
[Journal Article] The anti-amyloidogenic effect is exerted against Alzheimer's β-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure2007
- Author(s)
  Hirohata, M., Hasegawa, K., Tsutsumi-Yasuhara, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., Naiki, H.
- Journal Title
  
  Biochemistry 46(7)
  
  Pages: 1888-1899
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
- Author(s)
  Nagai, Y., Inui, T., Popiel, H.A., Fujikake, N., Hasegawa, K., Urade, Y., Goto, Y., Naiki, H., Toda, T.
- Journal Title
  
  Nat. Struct. Mol. Biol 14(4)
  
  Pages: 332-340
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Real-time and single fibril observation of the formation of amyloid β spherulitic structures2006
- Author(s)
  Ban, T., Morigaki, K., Yagi, H., Kawasaki, T., Kobayashi, A., Yuba, S., Naiki, H., Goto, Y.
- Journal Title
  
  J.Biol.Chem 281(44)
  
  Pages: 33677-33683
- NAID
  120006557651
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Seeding-dependent propagation and maturation of β_2-microglobulin amyloid fibrils under high pressure2006
- Author(s)
  Chatani, E., Naiki, H., Goto, Y.
- Journal Title
  
  J. Mol. Biol 359(4)
  
  Pages: 1086-1096
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Conformation of amyloid fibrils of β2-microglobulin probed by tryptophan mutagenesis2006
- Author(s)
  Kihara, M., Chatani, E., Iwata, K., Yamamoto, K., Matsuura, T., Nakagawa, A., Naiki, H., Goto, Y.
- Journal Title
  
  J.Biol.Chem 281(41)
  
  Pages: 31061-31069
- NAID
  120006557652
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] 3D structure of amyloid protofilaments of β2-microglobulin fragment probed by solid-state NMR2006
- Author(s)
  Iwata, K., Fujiwara, T., Matsuki, Y., Akutsu, H., Takahashi, S., Naiki, H., Goto, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 103(48)
  
  Pages: 18119-18124
- Data Source
  KAKENHI-PROJECT-18390120
[Journal Article] Molecular interactions in the formation and deposition of β_2-microglobulin-related amyloid fibrils.2005
- Author(s)
  Naiki, H. et al.
- Journal Title
  
  Amyloid 12(1)
  
  Pages: 15-25
- Data Source
  KAKENHI-PROJECT-16041217
[Journal Article] Molecular interactions in the formation and deposition of β_2-microglobulin-related amyloid fibrils.2005
- Author(s)
  Naiki, H. et al.
- Journal Title
  
  Amyloid 12(1)
  
  Pages: 15-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390123
[Journal Article] Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta amyloid fibrils in vitro.2004
- Author(s)
  Ono K, Hasegawa K, Naiki H, Yamada M.
- Journal Title
  
  J Neurosci Res 75
  
  Pages: 742-750
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Vitamin A exhibits potent anti-amyloidogenic and fibril-destabilizing effects in vitro.2004
- Author(s)
  Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M.
- Journal Title
  
  Exp Neurol 189
  
  Pages: 380-392
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.2004
- Author(s)
  Ono K, Hasegawa K, Naiki H, Yamada M.
- Journal Title
  
  Biochim Biophys Acta (Molecular Basis of Disease) 1690
  
  Pages: 193-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro : Implications for the prevention and therapeutics of Alzheimer's disease.2003
- Author(s)
  Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M.
- Journal Title
  
  J Neurochem 87
  
  Pages: 172-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Nicotine breaks down preformed Alzheimer's β-amyloid fibrils in vitro.2002
- Author(s)
  Ono K, Hasegawa K, Yamada M, Naiki H.
- Journal Title
  
  Biol Psychiatry 52
  
  Pages: 880-886
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Kinetic modeling and determination of reaction constants of Alzheimer's β-amyloid fibril extension and dissociation using surface plasm on resonance.2002
- Author(s)
  Hasegawa K, Ono K, Yamada M, Naiki H.
- Journal Title
  
  Biochemistry 41
  
  Pages: 13489-13498
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's β-amyloid fibrils in vitro.2002
- Author(s)
  Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H.
- Journal Title
  
  J Neurochem 81
  
  Pages: 434-440
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370203
[Journal Article] Cerebral amyloid anigopathy
- Author(s)
  Yamada M, Naiki H
- Journal Title
  
  Prog Mol Biol Transl Sci
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390242
[Journal Article] Lysophospholipids Induce the Nucleation and Extension of β2-Microglobulin-Related Amyloid Fibrils at a Neutral pH
- Author(s)
  Ookoshi, T., Hasegawa, K., Ohhashi, Y., Kimura, H., Takahashi, N., Yoshida, H., Miyazaki, R., Goto, Y., Naiki, H
- Journal Title
  
  Nephrol. Dial. Transplant (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570149
[Presentation] 前医の死後CTを確認することの大切さ2018
- Author(s)
  真橋　尚吾, 鈴木　史子, 山中　昭裕, 法木　左近, 小林　基弘, 稲井　邦博, 内木　宏延, 木下　一之, 坂井　豊彦, 江端　清和, 西島　昭彦, 木村　浩彦, 島田　一郎
- Organizer
  2018年Ai冬季症例検討会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] アミロイドーシス発症の分子機構と病型診断の重要性2018
- Author(s)
  内木　宏延
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] ヒトアミロイドーシス発症の分子機構2018
- Author(s)
  内木　宏延
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Class I small leucine-rich proteoglycans(SLRPs) colocalize with the Aβ2M amyloid deposits: Implications for the roles of SLRP core proteins in the pathogenesis of dialysis-related amyloidosis.2018
- Author(s)
  Yamaguchi I, Kokubo Y, Yamashita T, Ueda M, Okoshi T, Matsumine A, Ando Y, Naiki H
- Organizer
  The XVIth International Symposium on Amyloidosis 2018 Kumamoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] 病型診断の重要性とアミロイドーシス調査研究班の取り組み2018
- Author(s)
  内木　宏延
- Organizer
  第6回日本アミロイドーシス研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Latrogenic Creutzfeldt-Jakob disease related to Dura mater grafts.2017
- Author(s)
  Yamada M, Hamaguchi H, Sakai K, Noguchi-Shinohara M, Nozaki I, Taniguchi Y, Kobayashi A, Takeuchi A, Kitamoto T, Nakamura Y, Sanjo N, Tsukamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Mizusawa H
- Organizer
  PRION2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] 病理解剖遺体のオートプシー・イメージングに伴うCT検査室の環境調査結果2017
- Author(s)
  稲井　邦博, 法木　左近, 西島　昭彦, 飛田　征男, 岩崎　博道, 内木　宏延
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Possible human-to-human transmission of cerebral β-amyloidosis via cadaveric dura mater grafting.2017
- Author(s)
  Yamada M, Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H
- Organizer
  Alzheimer's Association International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] 墜落死に対する受傷機転の検討2017
- Author(s)
  真橋　尚吾, 鈴木　史子, 法木　左近, 小林　基弘, 稲井　邦博, 内木　宏延, 木下　一之, 坂井　豊彦, 江端　清和, 西島　昭彦, 木村　浩彦, 島田　一郎
- Organizer
  第15回オートプシー・イメージング(Ai)学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場, 福岡市
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K06965
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作，野村寮，Mangione P. Patrizia，長谷川一浩，大越忠和，Porcari Riccardo，Bellotti Vittorio，内木宏延
- Organizer
  第１６回日本蛋白質科学会
- Place of Presentation
  福岡県
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] Thioflavin T: Not an all-rounder, but a trustworthy friend for over 27 years.2016
- Author(s)
  Naiki H
- Organizer
  The XVth International Symposium on Amyloidosis
- Place of Presentation
  Uppsala Consert and Congre(Sweden)
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] アミロイド線維形成・細胞傷害の分子機構：β2-ミクログロブリンアミロイドーシスを中心に2016
- Author(s)
  内木宏延
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京）
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XVth International Symposium on Amyloidosis
- Place of Presentation
  Uppsala Consert and Congre(Sweden)
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] C反応性蛋白質と血清アミロイドP成分のアミロイド線維形成抑制および促進効果2016
- Author(s)
  小澤大作, 野村寮, Patrizia P. Mangione, 長谷川一浩, 大越忠和, Riccardo Porcari, Vittorio Bellotti, 内木宏延
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京）
- Data Source
  KAKENHI-PROJECT-16H05170
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XV International Symposium on Amyloidosis
- Place of Presentation
  Sweden
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] 透析アミロイド沈着部位に共存するグリコサミノグリカン及びプロテオグリカンの検討－病理切片を用いた免疫組織化学的観察とプロテオーム解析－2015
- Author(s)
  山口　格, 大越　忠和, 内田　研造, 田崎　雅義, 山下　太郎, 安東　由喜雄, 内木　宏延
- Organizer
  第3回日本アミロイドーシス研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] 滑膜線維芽細胞に対するβ2‐ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越忠和、山口格、長谷川一浩、小澤大作、内木宏延
- Organizer
  第2回日本アミロイドーシス研究会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-26860236
[Presentation] ヒトアミロイド線維形成・沈着の分子機構2013
- Author(s)
  内木　宏延
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本, 長野県松本文化会館
- Invited
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李映昊, 櫻井一正, 柳浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, NaikiH
- Organizer
  XIII^<th>International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] アミロイド線維形成・沈着の分子機構2012
- Author(s)
  内木宏延
- Organizer
  第58回日本病理学会総会秋季特別総会(ヒトの疾患解明に直結した最新の病理学研究)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen, the Netherlands (口頭発表およびポスター発表)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation.2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] アミロイド線維形成・沈着の分子機構2012
- Author(s)
  内木宏延
- Organizer
  第58回日本病理学会総会秋季特別総会（ヒトの疾患解明に直結した最新の病理学研究）
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] マウス F 型 apoA-II の C 末ペプチドは老化アミロイドーシス高発症マウスのアミロイド沈着を軽減する2012
- Author(s)
  澤下仁子, 張〓茄, 亀谷富由樹, 長谷川一浩, 森政之, 内木宏延, 樋口京一
- Organizer
  第27回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] β2-ミクログロブリンアミロイド線維形成・沈着の分子機構2011
- Author(s)
  内木宏延
- Organizer
  第56回日本透析医学会学術集会・総会
- Place of Presentation
  横浜(招待講演)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] β2-ミクログロブリンアミロイド線維形成・沈着の分子機構2011
- Author(s)
  内木宏延
- Organizer
  第56回日本透析医学会学術集会・総会
- Place of Presentation
  横浜(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] 超音波によるアミロイド線維形成促進2011
- Author(s)
  宗正智, 八木寿梓, 櫻井一正, 荻博次, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 伸長反応中間体の観察によるアミロイド構造伝播機構の解明2011
- Author(s)
  茶谷絵理, 小沼剛, 大西玲奈, 八木正典, 櫻井一正, 池上貴久, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会(蛋白質のフォールディングと異常凝集の統一原理)
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 蛍光色素チオフラビン T とレーザー光によるアミロイド線維の分解.2011
- Author(s)
  小澤大作, 加治優一, 八木寿梓櫻井一正, 川上徹, 内木宏延, 後藤祐児
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 超音波による amyloid β(1-40)の線維形成機構.2011
- Author(s)
  長谷川恭平, 八木寿梓, 志鷹裕司, 内木宏延, 後藤祐児
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 溶液 NMR による β2 ミクログロブリンアミロイド線維形成のモノマー-線維核相互作用機構の解明2011
- Author(s)
  櫻井一正, 柳浩太郎, 吉村優一, 小沼剛, 菅瀬謙治, 池上貴久, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] β2-ミクログロブリンアミロイド線維形成・沈着の分子機構2011
- Author(s)
  内木宏延
- Organizer
  第56回日本透析医学会学術集会・総会(透析アミロイドーシス UpDate)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] チオフラビン T とレーザー光を利用したアミロイド線維の分解2011
- Author(s)
  小澤大作, 加治優一, 八木寿梓, 櫻井一正, 川上徹, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 気液界面の影響を排除したアルツハイマー病 β アミロイド線維の核形成検出系の開発2011
- Author(s)
  長谷川一浩, 内木宏延
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 超音波処理下で作製した微細アミロイド線維の構造および物性のキャラクタリゼーション2011
- Author(s)
  吉村優一, 櫻井一正, 八木寿梓, 宗正智, 李映昊, 荻博次, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 超音波による K3 peptide と α-synuclein のアミロイド線維形成2010
- Author(s)
  水野愛子, 宗正智, 八木寿梓, 櫻井一正, 河田康志, 内木宏延, 後藤祐児
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Laser-induced propagation and destruction of amyloid β fibrils2010
- Author(s)
  Yagi H, Ozawa D, Sakurai K, Naiki H, Goto Y
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] The role of interfaces and agitation on the fibril formation of amyloid β-protein.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2010
- Place of Presentation
  Hawaii.
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] βアミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩、森永章義、山田正仁、内木宏延
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] 超音波による超高速アミロイド線維形成反応2010
- Author(s)
  宗正智, 八木寿梓, 櫻井一正, 内木宏延, 後藤祐児
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Transmissible amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II2010
- Author(s)
  Sawashita J, Kametani F, Hasegawa K, Mori M, Naiki H, Higuchi K
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] β アミロイド線維の核形成における界面の影響2010
- Author(s)
  長谷川一浩, 森永章義, 山田正仁, 内木宏延
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] a_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D., Hasegawa K., Lee YH., Sakurai K., Yanagi K., Ookoshi T., Goto Y., Naiki H.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara.
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy2010
- Author(s)
  Yoshimura Y, Sakurai K, Lee YH, Ikegami T, Chatani E, Naiki H, Goto Y
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] マウスF型apolipoprotein A-II(apoA-II)のC末アミノ酸配列はアミロイド線維形成を阻止する2010
- Author(s)
  澤下仁子、亀谷富由樹、長谷川一浩、張〓茄、王耀勇、森政之、内木延、樋口京一
- Organizer
  日本基礎老化学会第33回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] β_2-ミクログロブリンが形成するアミロイド線維の溶液 NMR による直接観察2010
- Author(s)
  吉村優一, 櫻井一正, 李映昊, 池上貴久, 茶谷絵理, 内木宏延, 後藤祐児
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] レーザー照射によるアミロイド線維の増殖と崩壊2010
- Author(s)
  八木寿梓, 小澤大作, 櫻井一正, 加治優一, 川上徹, 九山浩樹, 内木宏延, 後藤祐児
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular pathogenesis of β_2-microglobulin-related amyloidosis : The past, the present and the future2010
- Author(s)
  Naiki, H.
- Organizer
  International Symposium on Amyloidogenesis and Anti-Amyloid Therapies
- Place of Presentation
  Tokyo
- Year and Date
  2010-01-28
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] パルスラベル H/D 交換法と NMR を用いた β2ミクログロブリンの線維伸長中間体の解析2010
- Author(s)
  小沼剛, 茶谷絵理, 八木正典, 櫻井一正, 池上貴久, 内木宏延, 後藤祐児
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2009
- Author(s)
  内木宏延, 他
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] アミロイド線維形成・沈着の分子機構-β2-ミクログロブリンアミロイド線維を中心に-2009
- Author(s)
  内木宏延
- Organizer
  第60回日本電気泳動学会総会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] 遊離脂肪酸によるβ2-ミクログロブリンアミロイド線維伸長反応促進効果の解析2009
- Author(s)
  大越忠和、長谷川一浩、後藤祐児、内木宏延
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] 透析アミロイドーシス発症における血漿リゾリン脂質濃度の意義2009
- Author(s)
  高橋直生、木村秀樹、大越忠和、長谷川一浩、奈良雅文、宮崎良一、内木宏延、吉田治義
- Organizer
  第52回平成21年度日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2009
- Author(s)
  内木宏延, 長谷川一浩, 小野賢二郎, 山田正仁
- Organizer
  日本薬学会第129年会シンポジウム(S-22)「アミロイドβペプチドの凝集・毒性発現の分子メカニズムの解明と低分子化合物による阻害 : アルツハイマー病の克服に向けて」
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] アミロイド線維形成の重合核依存性重合モデルと線維形成阻害薬の探索2009
- Author(s)
  内木宏延, 他
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] ヒトアミロイドーシスの分子病態解明に向けて : 現状と展望2008
- Author(s)
  内木宏延
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] アミロイド線維形成・沈着の分子機構-ALアミロイドーシスを中心に-2008
- Author(s)
  内木宏延
- Organizer
  第9回東京腎炎・ネフローゼ研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] ヒトアミロイドーシスの分子病態解明に向けて : 現状と展望2008
- Author(s)
  内木宏延
- Organizer
  第8回日本蛋白質科学会年会シンポジウム「アミロイド構造生物学の新たな地平」
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] アミロイド線維形成・沈着の分子機構-ALアミロイドーシスを中心に-2008
- Author(s)
  内木宏延
- Organizer
  第9回東京腎炎・ネフローゼ研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] ヒトアミロイドーシスの分子病態解明に向けて2008
- Author(s)
  内木宏延
- Organizer
  日本ヒトプロテオーム機構第6回大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] ヒトアミロイドーシスの分子病態解明に向けて2008
- Author(s)
  内木宏延
- Organizer
  日本ヒトプロテオーム機構第6回大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20059015
[Presentation] ヒトアミロイドーシスの分子病態解明に向けて2008
- Author(s)
  内木宏延
- Organizer
  日本ヒトプロテオーム機構第6回大会シンポジウム「蛋白質のフォールディング病」
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] Molecular pathogenesis of β2-microglobulin-related amyloidosis2006
- Author(s)
  Naiki, H.
- Organizer
  24th Annual Meeting of the International Society of Blood Purification
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-18390120
[Presentation] Double tracer autoradiography with FDG/Cu-ATSM and immunohistochemical interpretation in 4 different mouse implanted tumor models2005
- Author(s)
  Tanaka T, Furukawa T, Kasamatsu S, Takamatsu S, Sunaga H, Fujieda S, Naiki H, Yonekura Y, Fujibayashi Y.
- Organizer
  Society of Nuclear Medicine 52 and Annual Meeting
- Place of Presentation
  Toronto, Canada
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591260
[Presentation] Double tracer autoradiography with FDG/Cu-ATSM and immunohistochemical interpretation in 4 different mouse inplanted tumor models2005
- Author(s)
  Tanaka T, Furukawa T, Kasamatsu S, Takamatsu S, Sunaga H, Fujieda S, Naiki H, Yonekura Y, Fujibayashi Y.
- Organizer
  Society of Nuclear Medicine 52nd Annual Meeting
- Place of Presentation
  Tronto, Canada
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591260
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する－形態解析を中心に－
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] Molecular pathogenesis of amyloid fibril formation and deposition
- Author(s)
  H.Naiki
- Organizer
  JSPS Japan Hungary Joint Seminar
- Place of Presentation
  大阪大学蛋白質研究所（大阪府吹田市）
- Year and Date
  2014-11-18 – 2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する-形態解析を中心に-
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24570129
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA JW Marriott Down
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils.
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis (USA)
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-24570129

1. HASEGAWA Kazuhiro (60324159)

# of Collaborated Projects: 26 results

# of Collaborated Products: 70 results
2. OOKOSHI Tadakazu (90362037)

# of Collaborated Projects: 13 results

# of Collaborated Products: 43 results
3. HIGUCH Keiichi (20173156)

# of Collaborated Projects: 9 results

# of Collaborated Products: 7 results
4. OZAWA Daisaku (60554524)

# of Collaborated Projects: 8 results

# of Collaborated Products: 39 results
5. GOTO Yuji (40153770)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
6. MORI Masayuki (60273190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. YAMADA Masahito (80191336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
8. BAN Tadato (00579667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NAKAKUKI Kazuya (90024629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. GEJYO Fumitake (20126410)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SAWASHITA Jinko (40359732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. KAMETANI Fuyuki (70186013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. MAEDA Shuichiro (10117244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHITA Mitsuhiro (60361995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SAKURAI Kazumasa (10403015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
16. FUJIWARA Toshimichi (20242381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. CHATANI Eri (00432493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. HAMANO TADANORI (40334817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Shirafuji Norimichi (40529319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HOSONO Masamichi (90107433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HOSHINO Masaru (70304053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. INAI Kunihiro (30313745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. NORIKI Sakon (30228374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. FURUKAWA Takako (00221557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. FUJIBAYASHI Yasuhisa (50165411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. FUJIEDA Shigeharu (30238539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. 今野卓 (50225637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 清野泰 (50305603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 小野正博 (80336180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Endo Yoshinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KITA Yoshikuni

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. KAMETANI Kiyokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. TAKAHASHI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. IWANO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. MORI Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. KASUNO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. KIMURA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
38. TSUKIMURA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. UEDA Mitsuharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 大嶋勇成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 北本哲之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 坂井健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 岩崎靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 鈴木貞夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 清水厚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 鈴木康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 八木寿梓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 李映昊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 飯野哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 定清直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 菅井学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 成田一衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 菊田健一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 笹原健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 宗正智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 徳力周子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 安東由喜雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 山下太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 井上泰輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
63. 浜野忠則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAIKI Hironobu 内木 宏延

内木 広延 ナイキ ヒロノブ

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生理濃度のnMレベルでのβアミロイド線維形成の検出と分子間相互作用の解析Ongoing

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アミロイドーシス発症の分子機構解明：蛋白質科学・マウスモデル・臨床病理学の融合Principal InvestigatorOngoing

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Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal modelsPrincipal Investigator

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アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明Principal Investigator

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Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse modelPrincipal Investigator

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NAIKI Hironobu 内木宏延

内木広延ナイキヒロノブ