MIWA YOSHIKAZU 三輪宜一

… Alternative Names

三輪宜一ミワヨシカズ

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Researcher Number	60346773
Other IDs	https://orcid.org/0000-0002-5687-7149
Affiliation (Current)	2025: 琉球大学, 医学(系)研究科(研究院), 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 琉球大学, 医学(系)研究科(研究院), 客員研究員 2010: Kyushu University, 医学(系)研究科(研究院), 助教 2007 – 2009: Kyushu University, 大学院・医学研究院, 助教 2005 – 2006: 九州大学, 大学院医学研究院, 助手 2004: 九州大学, 大学院・医学研究院, 助手 2003: 九州大学, 医学研究院, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 53020:Cardiology-related Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 動脈硬化 / L-PGDS / 15d-PGJ2 / プロスタグランジン / 血管内皮細胞 / COVID-19 / 白血球 / 血管炎症 / コルヒチン / 脂肪細胞分化 … More / PPAR-γ / メタボリックシンドローム / Apo E欠損マウス / 頸動脈障害モデル / ApoE 欠損マウス / 頭動脈障害モデル / 遺伝子解析 / オーダーメイド医療 / 血管細胞 / アポトーシス / 遺伝子多型 / クラステリン / シェアストレス / PWV / IMT / 血管平滑筋細胞 … More Except Principal Investigator 硝酸イソソルビド / 薬理遺伝学 / ゲノム薬理学 / 遺伝子多型 / 2型アルデヒド脱水素酵素 / 血管拡張 / 狭心症 / 二硝酸イソソルビド / ニトログリセリン / 硝酸薬 Less

Elucidation of the mechanism of action and signaling pathway of colchicine on vascular inflammationPrincipal Investigator
- Principal Investigator
  
  三輪宜一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  University of the Ryukyus
Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
メタボリックシンドロームの成因におけるL-PGDSの役割の検討Principal Investigator
- Principal Investigator
  
  三輪宜一
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
動物モデルを用いた動脈硬化病変形成におけるL-PGDSの役割の解明Principal Investigator
- Principal Investigator
  
  三輪宜一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
血管細胞におけるPGJ_2ファミリーの産生機構および薬理作用の解明Principal Investigator
- Principal Investigator
  
  三輪宜一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University

All 2022 2010 2009 2008 2007 2005 2004

All Journal Article Presentation Book

[Book] prostaglandin D2 synthase-A multitude of biological functions2008
- Author(s)
  Miwa, et. al.
- Publisher
  Research Signpost(in press)
- Data Source
  KAKENHI-PROJECT-18790178
[Journal Article] Effects of Low-Dose Colchicine on Serum High-Sensitivity C-Reactive Protein Level in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus and Enhanced Inflammatory Response Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase 2, Dose-Finding Study2022
- Author(s)
  Yoshikazu Miwa, Akiko Mutoh , Takeshi Morimoto, Yumi Ikehara, Takanori Yasu, Shinji Koba, Junya Ako, Yukihito Higashi, Masato Kajikawa, Hiroki Uehara, Kazuo Ishikawa, Ichiro Sakuma, Hirofumi Tomiyama, Koichi Node, Yuji Kumagai, Shinichiro Ueda
- Journal Title
  
  Biomed Hub .
  
  Volume: 7(3) Issue: 3 Pages: 156-164
- DOI
  10.1159/000527411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08106, KAKENHI-PROJECT-22K11292
[Journal Article] Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors-A multicenter, open, randomized trial using 24-hour urine collection.2010
- Author(s)
  Miwa Y, et al
- Journal Title
  
  Clin Exp Hypertens
  
  Volume: 32 Pages: 400-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390160
[Journal Article] Antiproteinuric Effect of Cilnidipine in Hypertensive Japanese Treated with Renin-Angiotensin-System Inhibitors.-A Multicenter, Open, Randomized Trial Using 24 Hour Urine Collection-2009
- Author(s)
  Miwa Y, et al.
- Journal Title
  
  Clin.Exp.Hypertens. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590254
[Journal Article] Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese2009
- Author(s)
  Miwa Y, et al.
- Journal Title
  
  Hypertens.Res. 32(12)
  
  Pages: 1112-1118
- NAID
  10026125024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590254
[Journal Article] Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.2008
- Author(s)
  Miwa Y., et al.
- Journal Title
  
  Hypertens. Res. 31
  
  Pages: 1931-1939
- NAID
  10024827726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390160
[Journal Article] Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.2008
- Author(s)
  Miwa Y, et al.
- Journal Title
  
  Hypertens Res. 31
  
  Pages: 1931-9
- NAID
  10024827726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590254
[Journal Article] Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females.2005
- Author(s)
  Miwa Y et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 331・4
  
  Pages: 1587-1593
- Data Source
  KAKENHI-PROJECT-15790137
[Journal Article] Involvement of clusterin in 15-deoxy-Δ^<12,14>-prostaglandin J_2 -induced vascular smooth muscle cell differentiation.2004
- Author(s)
  Miwa Y et al.
- Journal Title
  
  Biochem.Biophys.Res.Commum. 319(1)
  
  Pages: 163-168
- Data Source
  KAKENHI-PROJECT-15790137
[Journal Article] Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Jap2004
- Author(s)
  Miwa Y et al.
- Journal Title
  
  Biochem.Biophys.Res.Commum. 322(2)
  
  Pages: 428-433
- Data Source
  KAKENHI-PROJECT-15790137
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型ガニトログリセリンおとび二硝酸イソソルビドの血管拡張作用に印ぼす効果2010
- Author(s)
  吉原達也, 坂田智子, 白石富美恵, 鬼木秀幸, 市島久仁彦, 大坪俊夫, 三輪宜一, 高橋富美, 有馬久富, 松村潔, 笹栗俊之
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Effect of aldehyde dehydrogenase-2 gene polymorphism on vasodilatory response of brachial artery induced by nitroglycerin.2010
- Author(s)
  Sakata S, Matsumura K, Miwa Y, Oniki H, Ichishima K, Arima H, Takahashi-Yanaga F, Yoshihara T, Shiraishi F, Iida M, Sasaguri T
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  バンクーバー
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型がニトログリセリンおよび二硝酸イソソルビドの血管拡張作用に及ぼす影響2010
- Author(s)
  坂田智子, 松村潔, 三輪宜一, 鬼木秀幸, 市島久仁彦, 吉原達也, 高橋富美, 白石富美恵, 大坪俊夫, 笹栗俊之
- Organizer
  第33回日本高血圧学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Influence of aldehyde dehydrogenase-2 gene polymorphism on vasodilatation induced by organic nitrates in healthy human subjects.2010
- Author(s)
  Sakata S, Ichijima K, Oniki H, Miwa Y, Arima H, Matsumura K, Yoshihara T, Takahashi-Yanaga F, Shiraishi F, Sasaguri T
- Organizer
  WorldPharma 2010
- Place of Presentation
  コペンハーゲン
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Association of Serum Lipocalin-type Prostaglandin D Synthase Levels with Subclinical Atherosclerosis in Untreated Asymptomatic Subjects2009
- Author(s)
  三輪宜一, ほか
- Organizer
  日本循環器学会
- Place of Presentation
  大阪
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-20590254
[Presentation] Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.2009
- Author(s)
  Miwa Y., et al.
- Organizer
  第73回日本循環器学会総会・学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] リポカリン型プロスタグランジンD合成酵素(L-PGDS)遺伝子欠損は高脂肪食負荷マウスにおいて肥満及び動脈硬化を促進する2009
- Author(s)
  三輪宜一, 他
- Organizer
  第32回日本高血圧学会総会
- Place of Presentation
  大津
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] リポカリン型プロスタグランジンD合成酵素(1-pgds)遺伝子欠損は高脂肪食負荷マウスにおいて肥満及び動脈硬化を促進する2009
- Author(s)
  三輪宜一, ほか
- Organizer
  第32回日本高血圧学会総会
- Place of Presentation
  滋賀県大津市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20590254
[Presentation] レニン-アンジオテンシン系阻害薬投与下でのシルニジピンの蛋白尿減少効果-24時間家庭蓄尿での検討-2008
- Author(s)
  三輪宜一, 他.
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] β_1アドレナリン受容体遺伝子多型のアテノロール感受陛への影響の検討.2008
- Author(s)
  三輪宜一, 他.
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] 医薬品評価におけるファーマコゲノミクスの利用に関する今後の課題-アカデミアの立場から-(シンポジウム)2007
- Author(s)
  三輪宜一, et. al.
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-18790178
[Presentation] 血管平滑筋細胞における周期的伸展刺激による活性酸素産生へのアルドステロンの関与2007
- Author(s)
  三輪宜一, et. al.
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-18790178

1. SASAGURI Toshiyuki (30261209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. TAKAHASHI Fumi (50274436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MATSUMURA Kiyoshi (70285469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 田場洋二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 弥永富美

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

MIWA YOSHIKAZU 三輪 宜一

三輪 宜一 ミワ ヨシカズ

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of action and signaling pathway of colchicine on vascular inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

メタボリックシンドロームの成因におけるL-PGDSの役割の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動物モデルを用いた動脈硬化病変形成におけるL-PGDSの役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管細胞におけるPGJ_2ファミリーの産生機構および薬理作用の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] prostaglandin D2 synthase-A multitude of biological functions2008

Author(s)

Publisher

Data Source

[Journal Article] Effects of Low-Dose Colchicine on Serum High-Sensitivity C-Reactive Protein Level in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus and Enhanced Inflammatory Response Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase 2, Dose-Finding Study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors-A multicenter, open, randomized trial using 24-hour urine collection.2010

Author(s)

Journal Title

Data Source

[Journal Article] Antiproteinuric Effect of Cilnidipine in Hypertensive Japanese Treated with Renin-Angiotensin-System Inhibitors.-A Multicenter, Open, Randomized Trial Using 24 Hour Urine Collection-2009

Author(s)

Journal Title

Data Source

[Journal Article] Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females.2005

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of clusterin in 15-deoxy-Δ^<12,14>-prostaglandin J_2 -induced vascular smooth muscle cell differentiation.2004

Author(s)

Journal Title

Data Source

[Journal Article] Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Jap2004

Author(s)

Journal Title

Data Source

[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型ガニトログリセリンおとび二硝酸イソソルビドの血管拡張作用に印ぼす効果2010

MIWA YOSHIKAZU 三輪宜一

三輪宜一ミワヨシカズ