otsubo koshiro 大坪公士郎

… Alternative Names

大坪公士郎オオツボコウシロウ

Ohtsubo Koushiro 大坪公士郎

OHTSUBO Koshiro 大坪公士郎

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Researcher Number	60361987
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 附属病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 金沢大学, 附属病院, 講師 2017 – 2019: 金沢大学, 附属病院, 講師 2014: 金沢大学, 大学病院, 講師 2005: 金沢大学, 医学部附属病院, 講師 2004: 金沢大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 膵癌 / メチル化 / エピゲノム / 膵液 / miRNA / 早期診断 / リキッドバイオプシー / IPMN / マイクロRNA / ERCP … More / 胆道癌 / 血漿 / 胆汁 / CLDN5 / TFPI-2 / NPTX2 / SARP2 / ppENK / 慢性膵炎 / 膵管内乳頭腫瘍 … More Except Principal Investigator ボリノスタット / 個別化医療 / mTOR阻害薬 / EGFR阻害薬耐性 / BIM遺伝子多型 / ALK阻害薬耐性 / 肺がん / がん性髄膜炎 / がん性胸水 / イメージング / 転移 / がん性胸膜炎 / 骨転移 / 脳転移 / 分子標的薬耐性 Less

膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立Principal Investigator
- Principal Investigator
  
  大坪公士郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Aberrant Methylation of Tumor Suppressive miRNAs in Patients With Pancreatic CancerPrincipal Investigator
- Principal Investigator
  
  Ohtsubo Koushiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Study to overcome metastasis and targeted drug-resistance of lung cancer
- Principal Investigator
  
  YANO Seiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University
膵癌診断を目指した膵液中癌関連遺伝子のメチル化異常の検索Principal Investigator
- Principal Investigator
  
  大坪公士郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

All 2023 2022 2019 2018 2017 2014 2013 2012 2006 2005 2004

All Journal Article Presentation Patent

[Journal Article] Aberrant methylation of tumor suppressive miRNAs in bile from patients with pancreaticobiliary diseases.2019
- Author(s)
  Ohtsubo K, Miyake K, Arai S, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 39 Issue: 10 Pages: 5449-5459
- DOI
  10.21873/anticanres.13738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09456
[Journal Article] Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer.2014
- Author(s)
  Ohtsubo K, Yano S, et al.
- Journal Title
  
  Pancreas
  
  Volume: 43 Issue: 7 Pages: 1093-100
- DOI
  10.1097/mpa.0000000000000168
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-24300344, KAKENHI-PROJECT-24390209
[Journal Article] Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency.2013
- Author(s)
  Ohtsubo K, Yano S, et al.
- Journal Title
  
  JOP
  
  Volume: 14 Pages: 515-20
- DOI
  10.6092/1590-8577/1719
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-24390209
[Journal Article] Endoscopic findings of upper gastrointestinal lesions in patients withpancreatic cancer.2012
- Author(s)
  Ohtsubo K, Yano S, et al.
- Journal Title
  
  JOP
  
  Volume: 13(4) Pages: 420-6
- DOI
  10.6092/1590-8577/749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390209, KAKENHI-PLANNED-22112010
[Journal Article] 遺伝子診断2006
- Author(s)
  渡邊弘之, 大坪公士郎, 山口泰志, 澤武紀雄
- Journal Title
  
  日本臨牀 64
  
  Pages: 148-52
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] P53癌抑制遺伝子2006
- Author(s)
  澤武紀雄, 山口泰志, 渡邊弘之, 大坪公士郎
- Journal Title
  
  日本臨牀 64
  
  Pages: 36-40
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms2006
- Author(s)
  Watanabe H, Okada G, Ohtsubo K, et al.
- Journal Title
  
  Pancreas 未定(印刷中)
- NAID
  130004495735
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis.2005
- Author(s)
  Watanabe H, Okada G, Ohtsubo K, et al.
- Journal Title
  
  Pancreas (印刷中)
- NAID
  10016140810
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] Expression of Mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis2005
- Author(s)
  Watanabe H, Okada G, Ohtsubo K, et al.
- Journal Title
  
  Pancreas 30
  
  Pages: 349-354
- NAID
  10016140810
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] 腫瘍マーカー/消化器系 DU-PAN-22005
- Author(s)
  澤武紀雄, 渡邊弘之, 大坪公士郎
- Journal Title
  
  medicina 42
  
  Pages: 521-523
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas.2004
- Author(s)
  Wang Y, Yamaguchi Y, Watanabe H, Ohtsubo K, et al.
- Journal Title
  
  Pancreas 28(1)
  
  Pages: 13-19
- NAID
  10016166888
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] 膵癌の遺伝子診断2004
- Author(s)
  山口泰志, 大坪公士郎, 渡邊弘之, 澤武紀雄
- Journal Title
  
  外科治療 90(3)
  
  Pages: 258-263
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] 分子生物学からみた膵癌のリスクファクター2004
- Author(s)
  澤武紀雄, 大坪公士郎, 山口泰志, 渡邊弘之
- Journal Title
  
  肝胆膵 48(5)
  
  Pages: 567-572
- Data Source
  KAKENHI-PROJECT-16790377
[Journal Article] Serum tumor markers and molecular biological diagnosis in pancreatic cancer.2004
- Author(s)
  Sawabu N, Watanabe H, Yamaguchi Y, Ohtsubo K, et al.
- Journal Title
  
  Pancreas 28(3)
  
  Pages: 263-267
- NAID
  10016168161
- Data Source
  KAKENHI-PROJECT-16790377
[Patent] 特許権2018
- Inventor(s)
  大坪公士郎
- Industrial Property Rights Holder
  大坪公士郎
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 膵胆道疾患におけるリキッドバイオプシーを用いたmiRNAのメチル化異常の検討2023
- Author(s)
  大坪公士郎
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K07275
[Presentation] 内視鏡下採取及び血液検体を用いた各種膵胆道疾患におけるmiRNAのメチル化異常の検討2023
- Author(s)
  大坪公士郎
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-22K07275
[Presentation] 各種リキッドバイオプシーを用いた膵胆道疾患におけるmiRNAのメチル化異常の検討2022
- Author(s)
  大坪公士郎
- Organizer
  第104回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-22K07275
[Presentation] 内視鏡的経鼻膵管ドレナージによる膵液を用いた膵疾患におけるmiRNAのメチル化異常の検討2022
- Author(s)
  大坪公士郎
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K07275
[Presentation] Analyses of Aberrant Methylation of Tumor Suppressive miRNAs in Bile in Patients With Pancreaticobiliary Diseases.2019
- Author(s)
  Ohtsubo K, Miyake K, Arai S, et al.
- Organizer
  4.The 50th Anniversary Joint Meeting of American Pancreatic Association and Jappanese Pancreas Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 各種膵胆道疾患における胆汁中癌抑制型miRNAのメチル化に関する検討2019
- Author(s)
  大坪公士郎、山下　要、三宅邦夫など
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 胆汁中癌抑制型miRNAのメチル化解析による膵胆道疾患の良悪性鑑別に関する検討2019
- Author(s)
  大坪公士郎、三宅邦夫、矢野聖二
- Organizer
  第61回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] Analyses of aberrant methylation of tumor suppressive miRNAs in the patients with pancreaticobiliary diseases in bile juice.2018
- Author(s)
  Koushiro Ohtsubo
- Organizer
  Pancreas 2018
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 胆汁を用いた膵胆道疾患における癌抑制型miRNAのメチル化異常に関する検討2017
- Author(s)
  大坪公士郎、山下　要、三宅邦夫、矢野聖二
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09456

1. 山下要 (80456425)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 三宅邦夫 (60550712)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. YANO Seiji (30294672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. EBI Hiromichi (00645145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

otsubo koshiro 大坪 公士郎

大坪 公士郎 オオツボ コウシロウ

Ohtsubo Koushiro 大坪 公士郎

OHTSUBO Koshiro 大坪 公士郎

Research Projects

Research Products

Co-Researchers

膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Aberrant Methylation of Tumor Suppressive miRNAs in Patients With Pancreatic CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study to overcome metastasis and targeted drug-resistance of lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膵癌診断を目指した膵液中癌関連遺伝子のメチル化異常の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aberrant methylation of tumor suppressive miRNAs in bile from patients with pancreaticobiliary diseases.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoscopic findings of upper gastrointestinal lesions in patients withpancreatic cancer.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 遺伝子診断2006

Author(s)

Journal Title

Data Source

[Journal Article] P53癌抑制遺伝子2006

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis.2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Expression of Mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 腫瘍マーカー/消化器系 DU-PAN-22005

Author(s)

Journal Title

Data Source

[Journal Article] Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas.2004

Author(s)

otsubo koshiro 大坪公士郎

大坪公士郎オオツボコウシロウ

Ohtsubo Koushiro 大坪公士郎

OHTSUBO Koshiro 大坪公士郎