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otsubo koshiro  大坪 公士郎

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… Alternative Names

大坪 公士郎  オオツボ コウシロウ

Ohtsubo Koushiro  大坪 公士郎

OHTSUBO Koshiro  大坪 公士郎

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Researcher Number 60361987
Other IDs
External Links
Affiliation (Current) 2025: 金沢大学, 附属病院, 講師
Affiliation (based on the past Project Information) *help 2022 – 2023: 金沢大学, 附属病院, 講師
2017 – 2019: 金沢大学, 附属病院, 講師
2014: 金沢大学, 大学病院, 講師
2005: 金沢大学, 医学部附属病院, 講師
2004: 金沢大学, 医学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Respiratory organ internal medicine
Keywords
Principal Investigator
膵癌 / メチル化 / エピゲノム / 膵液 / miRNA / 早期診断 / リキッドバイオプシー / IPMN / マイクロRNA / ERCP … More / 胆道癌 / 血漿 / 胆汁 / CLDN5 / TFPI-2 / NPTX2 / SARP2 / ppENK / 慢性膵炎 / 膵管内乳頭腫瘍 … More
Except Principal Investigator
ボリノスタット / 個別化医療 / mTOR阻害薬 / EGFR阻害薬耐性 / BIM遺伝子多型 / ALK阻害薬耐性 / 肺がん / がん性髄膜炎 / がん性胸水 / イメージング / 転移 / がん性胸膜炎 / 骨転移 / 脳転移 / 分子標的薬耐性 Less
  • Research Projects

    (4 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (4 People)
  •  膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立Principal Investigator

    • Principal Investigator
      大坪 公士郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kanazawa University
  •  Aberrant Methylation of Tumor Suppressive miRNAs in Patients With Pancreatic CancerPrincipal Investigator

    • Principal Investigator
      Ohtsubo Koushiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  Study to overcome metastasis and targeted drug-resistance of lung cancer

    • Principal Investigator
      YANO Seiji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kanazawa University
  •  膵癌診断を目指した膵液中癌関連遺伝子のメチル化異常の検索Principal Investigator

    • Principal Investigator
      大坪 公士郎
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University

All 2023 2022 2019 2018 2017 2014 2013 2012 2006 2005 2004

All Journal Article Presentation Patent

  • [Journal Article] Aberrant methylation of tumor suppressive miRNAs in bile from patients with pancreaticobiliary diseases.2019

    • Author(s)
      Ohtsubo K, Miyake K, Arai S, et al.
    • Journal Title

      Anticancer Res

      Volume: 39 Issue: 10 Pages: 5449-5459

    • DOI

      10.21873/anticanres.13738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Journal Article] Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer.2014

    • Author(s)
      Ohtsubo K, Yano S, et al.
    • Journal Title

      Pancreas

      Volume: 43 Issue: 7 Pages: 1093-100

    • DOI

      10.1097/mpa.0000000000000168

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-24300344, KAKENHI-PROJECT-24390209
  • [Journal Article] Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency.2013

    • Author(s)
      Ohtsubo K, Yano S, et al.
    • Journal Title

      JOP

      Volume: 14 Pages: 515-20

    • DOI

      10.6092/1590-8577/1719

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-24390209
  • [Journal Article] Endoscopic findings of upper gastrointestinal lesions in patients withpancreatic cancer.2012

    • Author(s)
      Ohtsubo K, Yano S, et al.
    • Journal Title

      JOP

      Volume: 13(4) Pages: 420-6

    • DOI

      10.6092/1590-8577/749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390209, KAKENHI-PLANNED-22112010
  • [Journal Article] 遺伝子診断2006

    • Author(s)
      渡邊弘之, 大坪公士郎, 山口泰志, 澤武紀雄
    • Journal Title

      日本臨牀 64

      Pages: 148-52

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] P53癌抑制遺伝子2006

    • Author(s)
      澤武紀雄, 山口泰志, 渡邊弘之, 大坪公士郎
    • Journal Title

      日本臨牀 64

      Pages: 36-40

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms2006

    • Author(s)
      Watanabe H, Okada G, Ohtsubo K, et al.
    • Journal Title

      Pancreas 未定(印刷中)

    • NAID

      130004495735

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis.2005

    • Author(s)
      Watanabe H, Okada G, Ohtsubo K, et al.
    • Journal Title

      Pancreas (印刷中)

    • NAID

      10016140810

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] Expression of Mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis2005

    • Author(s)
      Watanabe H, Okada G, Ohtsubo K, et al.
    • Journal Title

      Pancreas 30

      Pages: 349-354

    • NAID

      10016140810

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] 腫瘍マーカー/消化器系 DU-PAN-22005

    • Author(s)
      澤武紀雄, 渡邊弘之, 大坪公士郎
    • Journal Title

      medicina 42

      Pages: 521-523

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas.2004

    • Author(s)
      Wang Y, Yamaguchi Y, Watanabe H, Ohtsubo K, et al.
    • Journal Title

      Pancreas 28(1)

      Pages: 13-19

    • NAID

      10016166888

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] 膵癌の遺伝子診断2004

    • Author(s)
      山口泰志, 大坪公士郎, 渡邊弘之, 澤武紀雄
    • Journal Title

      外科治療 90(3)

      Pages: 258-263

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] 分子生物学からみた膵癌のリスクファクター2004

    • Author(s)
      澤武紀雄, 大坪公士郎, 山口泰志, 渡邊弘之
    • Journal Title

      肝胆膵 48(5)

      Pages: 567-572

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Journal Article] Serum tumor markers and molecular biological diagnosis in pancreatic cancer.2004

    • Author(s)
      Sawabu N, Watanabe H, Yamaguchi Y, Ohtsubo K, et al.
    • Journal Title

      Pancreas 28(3)

      Pages: 263-267

    • NAID

      10016168161

    • Data Source
      KAKENHI-PROJECT-16790377
  • [Patent] 特許権2018

    • Inventor(s)
      大坪公士郎
    • Industrial Property Rights Holder
      大坪公士郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Presentation] 膵胆道疾患におけるリキッドバイオプシーを用いたmiRNAのメチル化異常の検討2023

    • Author(s)
      大坪公士郎
    • Organizer
      第109回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-22K07275
  • [Presentation] 内視鏡下採取及び血液検体を用いた各種膵胆道疾患におけるmiRNAのメチル化異常の検討2023

    • Author(s)
      大坪公士郎
    • Organizer
      第54回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-22K07275
  • [Presentation] 各種リキッドバイオプシーを用いた膵胆道疾患におけるmiRNAのメチル化異常の検討2022

    • Author(s)
      大坪公士郎
    • Organizer
      第104回日本消化器内視鏡学会総会
    • Data Source
      KAKENHI-PROJECT-22K07275
  • [Presentation] 内視鏡的経鼻膵管ドレナージによる膵液を用いた膵疾患におけるmiRNAのメチル化異常の検討2022

    • Author(s)
      大坪公士郎
    • Organizer
      第108回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-22K07275
  • [Presentation] Analyses of Aberrant Methylation of Tumor Suppressive miRNAs in Bile in Patients With Pancreaticobiliary Diseases.2019

    • Author(s)
      Ohtsubo K, Miyake K, Arai S, et al.
    • Organizer
      4.The 50th Anniversary Joint Meeting of American Pancreatic Association and Jappanese Pancreas Society.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Presentation] 各種膵胆道疾患における胆汁中癌抑制型miRNAのメチル化に関する検討2019

    • Author(s)
      大坪公士郎、山下 要、三宅邦夫など
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Presentation] 胆汁中癌抑制型miRNAのメチル化解析による膵胆道疾患の良悪性鑑別に関する検討2019

    • Author(s)
      大坪公士郎、三宅邦夫、矢野聖二
    • Organizer
      第61回日本消化器病学会大会
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Presentation] Analyses of aberrant methylation of tumor suppressive miRNAs in the patients with pancreaticobiliary diseases in bile juice.2018

    • Author(s)
      Koushiro Ohtsubo
    • Organizer
      Pancreas 2018
    • Data Source
      KAKENHI-PROJECT-17K09456
  • [Presentation] 胆汁を用いた膵胆道疾患における癌抑制型miRNAのメチル化異常に関する検討2017

    • Author(s)
      大坪公士郎、山下 要、三宅邦夫、矢野聖二
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09456
  • 1.  山下 要 (80456425)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  三宅 邦夫 (60550712)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 3.  YANO Seiji (30294672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  EBI Hiromichi (00645145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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