FUJIMOTO Hirofumi 藤本浩文

… Alternative Names

藤本浩文フジモトヒロフミ

FUJIMOTO Hirohumi 藤本浩文

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Researcher Number	60373396
Affiliation (Current)	2025: 国立感染症研究所, 品質管理研究センター, 室長
Affiliation (based on the past Project Information) *help	2017 – 2021: 国立感染症研究所, 品質保証・管理部, 室長 2016: 国立感染症研究所, 品質保証・管理部, 主任研究官 2014 – 2015: 国立感染症研究所, その他部局等, 研究員 2013 – 2014: 国立感染症研究所, 品質保証・管理部, 主任研究官 2009 – 2012: National Institute of Infectious Diseases, 放射能管理室, 主任研究官 … More 2006: National Institute of Infectious Diseases, Division of Radiological Protection and Biology, Senior Researcher, 放射線管理室, 主任研究官 2006: 国立感染症研究所, 放射能管理室, 主任研究官 2004 – 2005: 国立感染症研究所, 放射能管理室, 研究官 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals / Applied entomology Except Principal Investigator Immunology / Applied entomology
Keywords	Principal Investigator 分子シミュレーション / Ku / DNA二本鎖切断 / ライブセルイメージング / DNA損傷認識 / アセチル化 / 核移行シグナル(NLS) / 核移行シグナル (NLS) / Importin / 核移行シグナル（NLS） … More / アセチルリジン / Ku70 / DNA二本鎖切断修復 / NHEJ / APサイト / DSB修復 / DNA修復 / クラスターDNA損傷 / クラスターDNA損傷修復 / 損傷認識 / 損傷修復 / DNA損傷修復 / Kuタンパク質 / 分子動力学シミュレーション / AMBER 7 / トレロトランスポゾンR1Bm / 分子動力学的(MD)シミュレーション / Amber7 / シミュレーション / 分子動力学的 / human AP endonuclease (hAP1) / レトロトランスポゾンR1Bm … More Except Principal Investigator 体細胞突然変異 / 立体構造モデリング / VDJ遺伝子再構成 / 抗体応答 / B細胞分化 / 代替軽鎖 / 抗体レパトア / 次世代シークエンサ / プレB細胞受容体 / 次世代シークエンサー / VDJ遺伝子再構成制御 / 抗原抗体反応測定 / 抗体遺伝子合成 / 抗原応答抗体予測 / 自己抗原反応レパトア / 抗体レパトア発生機構 / 抗体レパトア全体像 / Transgenic / White blood gene / Yellow blood gene / Mutant / Carotenoid-binding protein / Lutein / Bomby mori / 突然変異体 / カロチノイドの細胞透過 / リボホリン / スプライシング / 遺伝子構造 / カロチノイド結合タンパク質 / カロチノイドの吸収 / リポホリン / 細胞内透過機構 / 脂質輸送 / カイコ / 黄血遺伝子 / 突然変異 / カロチノイド結合タンパク / カロチノイド / Bombyx mori Less

Theoretical and experimental analysis for the nuclear transport mechanism of double-strand break repair protein, Ku70Principal Investigator
- Principal Investigator
  
  Fujimoto Hirofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Institute of Infectious Diseases
Theoretical and experimental analysis of the binding efficiency of Ku protein to radiation induced clustered DNA damagesPrincipal Investigator
- Principal Investigator
  
  Fujimoto Hirofumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Infectious Diseases
Explicit representation of holistic antibody repertoire by exhaustive RNA sequencing and the antibody expression by reverse genetics.
- Principal Investigator
  
  OHNISHI Kazuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
Structural analysis of the binding mechanism of the Ku protein to DNA that contains overhangs in its endPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO HIROFUMI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Infectious Diseases
Structural analysis of the interaction between the Ku protein and DNAPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Hirofumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Infectious Diseases
Function and Role of I gene concerning carotenoid transport
- Principal Investigator
  
  TSUCHIDA Kozo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied entomology
- Research Institution
  National Institute of Infectious Diseases
non-LTR型レトロトランスポゾンRlBmの標的部位認識機構の解明Principal Investigator
- Principal Investigator
  
  藤本浩文
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied entomology
- Research Institution
  National Institute of Infectious Diseases

All 2019 2017 2015 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis2012
- Author(s)
  Hirofumi Fujimoto, Mariko Higuchi, Manabu Koike, Hirotaka Ode, Miroslav Pinak, Juraj Kotulic Bunta, Toshiyuki Nemoto, Takashi Sakudoh, Naoko Honda, Hideaki Maekawa, Kimiaki Saito, Kozo Tsuchida
- Journal Title
  
  J. Comput. Chem
  
  Volume: 33 Issue: 3 Pages: 239-246
- DOI
  10.1002/jcc.21956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21510063, KAKENHI-PROJECT-22310038
[Journal Article] Mechanism of tissue specificity of carotenoids delivery in the silkworm.2007
- Author(s)
  Sakudoh T., Takada N., Fujimoto H., Tsuchida K.
- Journal Title
  
  Carotenoid Sci. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Mapping Analysis of carotenoid-binding protein of Bombyx mori by restriction fragment length polymorphism.2007
- Author(s)
  Hara W., Sosnicki S., Banno Y., Fujimoto H., Takada N., Maekawa H., Fujii H., Wells MA, Tsuchida K.
- Journal Title
  
  J.Insect Biotech. Seric. (in press)
- NAID
  10019767265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of Yellow blood gene2007
- Author(s)
  Sakudoh T., Sezutsu H., Nakashima T., Kobayashi I., Fujimoto H., Uchino K., Banno Y., Iwano H., Maekawa H., Tamura T., Kataoka H., Tsuchida K.
- Journal Title
  
  Proc. Natl. Aca. Sci. USA. 104
  
  Pages: 8941-8946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Mapping Analysisi of carotenoid-binding protein of Bombyx mori by restriction fragment length polymorphism.2007
- Author(s)
  Hara W., Sosnicki S., Banno Y., Fujimoto H., Takada N., Maekawa H., Fujii H., Wells MA, Tsuchida K.
- Journal Title
  
  J. Insect Biotech. Seric. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Structural analysis of base mispairing in DNA containing oxidative guanine lesion2007
- Author(s)
  Fujimoto H., Pinak M., Nemoto T., Bunta JK
- Journal Title
  
  CEJP 5
  
  Pages: 40-61
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Structural analysis of base mispairing in DNA containing oxidative guanine lesion2007
- Author(s)
  Hirofumi Fujimoto, Miroslav Pinak, Toshiyuki Nemoto, Juraj Kotulic Bunta
- Journal Title
  
  Central European Journal of Physics 5(1)
  
  Pages: 49-61
- Data Source
  KAKENHI-PROJECT-16780042
[Journal Article] Mechanism of tissue specificity of carotenoids delivery in the silkworm.2007
- Author(s)
  Sakudoh T., Takada N., Fujimoto H., Tsuchida K.
- Journal Title
  
  Carotenoid Sci. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of Yellow blood gene2007
- Author(s)
  Sakudoh T., Sezutsu H., Nakashima T., Kobayashi I., Fujimoto H., Uchino K., Banno Y., Iwano H., Maekawa H., Tamura T., Kataoka H., Tsuchida K.
- Journal Title
  
  Proc. Natl. Aca. Sci. USA 104
  
  Pages: 8941-8946
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] A novel indicator for radiation sensitivity using the wing size reduction of Bombyx mori pupae caused by g-ray irradiation2006
- Author(s)
  Takada N., Yamauchi E., Fujimoto H., Banno Y., Tsuchida K., Hashido K., Nakajima Y., Tu Z., Takahashi M., Fujii M., Fugo H., Maekawa H.
- Journal Title
  
  J. Insect Biotech and Seric. 75
  
  Pages: 161-165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] A novel indicator for radiation sensitivity using the wing size reduction of Bombyx mori pupae caused by g-ray irradiation2006
- Author(s)
  Takada N., Yamauchi E., Fujimoto H., Banno Y., Tsuchida K., Hashido K., Nakajima Y., Tu Z., Takahashi M., Fujii M., Fugo H., Maekawa H.
- Journal Title
  
  J.Insect Biotech and Seric. 75
  
  Pages: 161-165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] A novel indicator for radiation sensitivity using the wing size reduction of Bombyx mori pupae caused by-ray irradiation.2006
- Author(s)
  Takada N., Yamauchi E., Fujimoto H., Banno Y., Tsuchida K., Hashida K., Nakajima Y., Tu Z., Takahashi M., Fujii H., Fugo H., Maekawa H.
- Journal Title
  
  Journal of Insect Biotechnology and Sericology 75(in press)
- Data Source
  KAKENHI-PROJECT-17580049
[Journal Article] Molecular dynamics simulation of clustered DNA damage sites containing 8-oxoguanine and abasic site2005
- Author(s)
  Hirofumi Fujimoto et al.
- Journal Title
  
  Journal of Computational Chemistry 26
  
  Pages: 788-798
- Data Source
  KAKENHI-PROJECT-16780042
[Journal Article] Molecular dynamics simulation of clustered DNA damage sites containing 8-oxoguanine and abasic site
- Author(s)
  Hirofumi Fujimoto et al.
- Journal Title
  
  Journal of Computational Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-16780042
[Presentation] Acetylation of nuclear localization signal controls importin-mediated nuclear transport of Ku702019
- Author(s)
  Fujimoto H, Ikuta T, Koike A, Koike M
- Organizer
  The 16th International Congress of Radiation Research (ICRR2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12337
[Presentation] 計算化学的手法を用いたKu70のアセチル化の効果の解析2017
- Author(s)
  藤本浩文，生田統悟，小池亜紀，小池学
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-16K00554
[Presentation] クラスターDNA損傷とその修復酵素の構造解析2015
- Author(s)
  藤本浩文、樋口真理子、渡辺立子、甲斐健師、藪英治、斎藤公明、Miroslav Pinak、加藤篤
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Structural analysis of the interaction between the Ku protein and DNA2011
- Author(s)
  Fujimoto H, et al
- Organizer
  The 14th International Congress of Radiation Research (ICRR2011)
- Place of Presentation
  Warsaw, Czech republic(招待講演)
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21510063
[Presentation] Structural analysis of the interaction between the Ku protein and DNA2011
- Author(s)
  Fujimoto H
- Organizer
  The 14th International Congress of Radiation Research(ICRR2011)
- Place of Presentation
  Warsaw, Czech republic
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21510063
[Presentation] 計算化学的手法を用いたKuタンパク質とDNAの相互作用部位の構造解析2010
- Author(s)
  藤本浩文
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  兵庫
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21510063
[Presentation] 計算化学的手法を用いたKuタンパク質とDNAの相互作用部位の構造解析2010
- Author(s)
  藤本浩文, 樋口真理子, 小池学, Miroslav Pinak, Juraj Kotulic Bunta, 根本俊行, 前川秀彰, 作道隆, 高田直子, 土田耕三
- Organizer
  BMB2010事務局(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸ホトアイランド(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21510063
[Presentation] Structural analysis of the interaction between the Ku protein and DNA2009
- Author(s)
  藤本浩文
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21510063
[Presentation] Structural analysis of the interaction between the Ku protein and DNA2009
- Author(s)
  藤本浩文
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21510063

1. KOIKE Manabu (70280740)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. TSUCHIDA Kozo (40231435)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. SAKUDOH Takashi (70455393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. OHNISHI Kazuo (90169011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 藤博幸 (70192656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 野口保 (00357740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

FUJIMOTO Hirofumi 藤本 浩文

藤本 浩文 フジモト ヒロフミ

FUJIMOTO Hirohumi 藤本 浩文

Research Projects

Research Products

Co-Researchers

Theoretical and experimental analysis for the nuclear transport mechanism of double-strand break repair protein, Ku70Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Theoretical and experimental analysis of the binding efficiency of Ku protein to radiation induced clustered DNA damagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Explicit representation of holistic antibody repertoire by exhaustive RNA sequencing and the antibody expression by reverse genetics.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analysis of the binding mechanism of the Ku protein to DNA that contains overhangs in its endPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analysis of the interaction between the Ku protein and DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function and Role of I gene concerning carotenoid transport

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

non-LTR型レトロトランスポゾンRlBmの標的部位認識機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanism of tissue specificity of carotenoids delivery in the silkworm.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mapping Analysis of carotenoid-binding protein of Bombyx mori by restriction fragment length polymorphism.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of Yellow blood gene2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mapping Analysisi of carotenoid-binding protein of Bombyx mori by restriction fragment length polymorphism.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Structural analysis of base mispairing in DNA containing oxidative guanine lesion2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Structural analysis of base mispairing in DNA containing oxidative guanine lesion2007

FUJIMOTO Hirofumi 藤本浩文

藤本浩文フジモトヒロフミ

FUJIMOTO Hirohumi 藤本浩文