ishiyama ken 石山謙

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Ishiyama Ken 石山謙

ISHIYAMA Ken 石山謙

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Researcher Number	60377380
Other IDs
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療センター, 医長
Affiliation (based on the past Project Information) *help	2016 – 2022: 金沢大学, 附属病院, 講師 2011: 金沢大学, 医学系, 協力研究員 2004: Kanazawa University Hospital, Instructor, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Hematology / Laboratory medicine
Keywords	Principal Investigator 血液免疫学 / WT1 / トロンボポエチン受容体作動薬 / minute PNH顆粒球 / クロナリティ / miniscule PNH顆粒球 / クローン性造血 / 体細胞遺伝子変異 / ロミプロスチム / トロンボポエチン受容体作動薬（TPO-RA） … More / 再生不良性貧血 / LRCH1 / 13番染色体長腕の部分欠失（del(13q) / CD109 / 赤血球分化 / TGF-β / OLFM4 / 13番染色体長腕の部分欠失（del(13q)） / 自己免疫性造血不全 … More Except Principal Investigator HLA-DR15 / DRS-1 / 自己抗体 / PNH / 再生不良性貧血 / 白血病 / 癌 / バイオマーカー / 骨髄異形成症候群 / moesin / autoantigen / aplastic anemia / 慢性骨髄性白血病 / モエシン / RB遺伝子 / 13q- / GPI-アンカー膜蛋白 / PNH型血球 / 骨髄不全 / CD109 / TGF-β / GPIアンカー膜蛋白 / 自己抗原 / 細胞傷害性T細胞 / HLA / 6pUPD Less

Effects of romiplostim, a thrombopoietin receptor agonist, on hematopoiesis and DNA repairPrincipal Investigator
- Principal Investigator
  
  Ishiyama Ken
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Analysis of mechanisms underlying preferential commitment of hematopoietic stem cells with del(13q) in patients with autoimmune hematopoietic failurePrincipal Investigator
- Principal Investigator
  
  Ishiyama Ken
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Development of diagnostic kit for myelodysplastic anemia
- Principal Investigator
  
  Sugiyama Daisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University
Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure
- Principal Investigator
  
  NAKAO Shinji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Analysis of autoantigens in aplastic anemia : identification of an epitope recognized by CD4^+ T cells specific to hematopoietic progenitor cells
- Principal Investigator
  
  NAKAO Shinji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University

All 2022 2021 2020 2011 2009 2004

All Journal Article Presentation

[Journal Article] Clinical significance of the increased expression of the WT1 gene in peripheral blood of patients with acquired aplastic anemia2022
- Author(s)
  Ishiyama Ken、Dung Tran Cao、Imi Tatsuya、Hosokawa Kohei、Nannya Yasuhito、Yamazaki Hirohito、Ogawa Seishi、Nakao Shinji
- Journal Title
  
  eJHaem
  
  Volume: 3 Issue: 4 Pages: 1116-1125
- DOI
  10.1002/jha2.563
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-20K08708
[Journal Article] Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR152022
- Author(s)
  Tsuji Noriaki、Hosokawa Kohei、Urushihara Ryota、Tanabe Mikoto、Katagiri Takamasa、Ozawa Tatsuhiko、Takamatsu Hiroyuki、Ishiyama Ken、Yamazaki Hirohito、Kishi Hiroyuki、Ogawa Seishi、Nakao Shinji
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 6 Pages: 1666-1675
- DOI
  10.1038/s41375-022-01549-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-22K08473, KAKENHI-PROJECT-21H02962, KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K08708
[Journal Article] Paroxysmal nocturnal hemoglobinuria‐phenotype cells predict a good response to eltrombopag in patients with refractory aplastic anemia2020
- Author(s)
  Ishiyama Ken、Sato Keijiro、Imi Tatsuya、Hosokawa Kohei、Kondo Yukio、Sugimori Naomi、Yamazaki Hirohito、Nakao Shinji
- Journal Title
  
  eJHaem
  
  Volume: 1 Issue: 1 Pages: 243-248
- DOI
  10.1002/jha2.51
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08708
[Journal Article] Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure2009
- Author(s)
  Sugimori, C., Mochizuki, K., Qi, Z., Sugimori, N., Ishiyama, K., Kondo, Y., Yamazaki, H., Takami, A., Okumura, H., Nakao, S.
- Journal Title
  
  Br J Haematol
  
  Volume: 147 Pages: 102-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Origin and fate of blood cells deficient in glycosylphosphatidylino sitol-anchored protein among patients with bone marrow failure.2009
- Author(s)
  Sugimori C, Mochizuki K, Qi Z, Sugimori N, Ishiyama K, Kondo Y, Yamazaki H, Takami A, Okumura H, Nakao S
- Journal Title
  
  Br J Haematol 147
  
  Pages: 102-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Graft-versus-leukemia effect of allogeneic stem cell transplantation : a Japanese single center study.2004
- Author(s)
  Ishiyama K, Takami A, Shiobara S, Koizumi S, Nakao S
- Journal Title
  
  Haemarologica 89-7
  
  Pages: 887-889
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390298
[Journal Article] Graft-versus-leukemia effect of allogeneic stem cell transplantation ; a Japanese single center study.2004
- Author(s)
  Ishiyama K, et al.
- Journal Title
  
  Haematologica 89・7
  
  Pages: 887-889
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390298
[Presentation] Presence of minute GPI(-) granulocytes represents non-immune pathophysiology of bone marrow failure2022
- Author(s)
  Dung Cao Tran、Hiroki Mizumaki、Kohei Hosokawa、Hiroyuki Takamatsu、Hirohito Yamazaki、Ken Ishiyama、Toshihiro Miyamoto、Shinji Nakao
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08708
[Presentation] Low incidence of MDS-related gene mutations in patients with long-standing AA refractory to IST2022
- Author(s)
  井美達也、南谷泰仁、材木義隆、丸山裕之、細川晃平、吉田晶代、高松博幸、石山謙、山崎宏人、小川　誠司、宮本敏浩、中尾眞二
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08708
[Presentation] Markedly high prevalence of HLA-lacking leukocytes in patients with very severe aplastic anemia.2021
- Author(s)
  10.Tatsuya Imi，Ryota Urushihara，Noriaki Tsuji，Mikoto Tanabe，Hiroki Mizumaki，Yoshitaka Zaimoku，Kohei Hosokawa，Hiroyuki Takamatsu，Ken Ishiyama，Hirohito Yamazaki，Shinji Nakao.
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08708
[Presentation] TPO-RA長期投与中の難治性再生不良性貧血患者では体細胞変異が検出されることは稀である2020
- Author(s)
  井美達也、南谷泰仁、細川晃平、岩城憲子、高松博幸、石山謙、山﨑宏人、小川誠司、中尾眞二
- Organizer
  日本血液学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08708
[Presentation] Bone marrow failure with 13q deletion : A distinct clinicopathological entity with immune pathophysiology2011
- Author(s)
  Hosokawa, K., Katagir, T., Sugimori, N., Ishiyama, K., Sasaki, Y., Seiki, Y., Sato-Otsubo, A., Sanad a, M., MD, Ogawa, S., Nakao, S.
- Organizer
  The American Society of Hematology 53rd Annual Meeting
- Place of Presentation
  San Diego Convention Center(California, USA.)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21390291
[Presentation] Bone marrow failure with 13q deletion : A distinct clinicopat hological entity with immune pathophysiology2011
- Author(s)
  Kohei Hosokawa, Takamasa Katagir, Naomi Sugimori, Ken Ishiyama, Yumi Sasaki, Yu Seiki, Aiko Sato-Otsubo, Masashi Sanada, MD, Seishi Ogawa, Shinji Nakao
- Organizer
  The American Society of Hematology 53rd Annual Meeting
- Place of Presentation
  San Diego Convention Center, California, USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21390291

1. NAKAO Shinji (70217660)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. YAMAZAKI Hirohito (50361994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KONDO Yukio (10322116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. TAKAMATSU Hiroyuki (70401932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. CHUHJO Tatsuya (00303298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAMI Akiyoshi (80324078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Sugiyama Daisuke (00426652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 細道一善 (50420948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKAWA Katsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中尾真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
11. 細川晃平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

ishiyama ken 石山 謙

Ishiyama Ken 石山 謙

ISHIYAMA Ken 石山 謙

Research Projects

Research Products

Co-Researchers

Effects of romiplostim, a thrombopoietin receptor agonist, on hematopoiesis and DNA repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mechanisms underlying preferential commitment of hematopoietic stem cells with del(13q) in patients with autoimmune hematopoietic failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of diagnostic kit for myelodysplastic anemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of autoantigens in aplastic anemia : identification of an epitope recognized by CD4^+ T cells specific to hematopoietic progenitor cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical significance of the increased expression of the WT1 gene in peripheral blood of patients with acquired aplastic anemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR152022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Paroxysmal nocturnal hemoglobinuria‐phenotype cells predict a good response to eltrombopag in patients with refractory aplastic anemia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure2009

Author(s)

Journal Title

Data Source

[Journal Article] Origin and fate of blood cells deficient in glycosylphosphatidylino sitol-anchored protein among patients with bone marrow failure.2009

Author(s)

Journal Title

Data Source

[Journal Article] Graft-versus-leukemia effect of allogeneic stem cell transplantation : a Japanese single center study.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Graft-versus-leukemia effect of allogeneic stem cell transplantation ; a Japanese single center study.2004

Author(s)

Journal Title

Description

Data Source

[Presentation] Presence of minute GPI(-) granulocytes represents non-immune pathophysiology of bone marrow failure2022

Author(s)

Organizer

Data Source

[Presentation] Low incidence of MDS-related gene mutations in patients with long-standing AA refractory to IST2022

Author(s)

Organizer

Data Source

[Presentation] Markedly high prevalence of HLA-lacking leukocytes in patients with very severe aplastic anemia.2021

Author(s)

Organizer

ishiyama ken 石山謙

Ishiyama Ken 石山謙

ISHIYAMA Ken 石山謙