Liu Shuang 劉爽

Researcher Number	60403812
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 愛媛大学, 医学系研究科, 准教授 2018 – 2020: 愛媛大学, 医学系研究科, 准教授 2016 – 2017: 愛媛大学, 医学系研究科, 講師 2015: 愛媛大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 関節リウマチ / 免疫抑制剤 / ゲノム修飾 / ループス腎炎 / 胎生期脂質環境 / 全身エリテマトーデス / ゲノム編集 / 抗リウマチ薬 / 関節軟骨再生 / 軟骨細胞 … More / 関節再生能 / 異種移植モデル / 軟骨再生 / 免疫抑制薬 / 軟骨移植 / 間葉系幹細胞 / 臨床研究 / 薬理効果 / SCIDマウス / ヒト型関節リウマチモデル / CARCチャネル阻害薬 / Short-hairpin RNA / 核酸製剤 / 抗体製剤 / カルシウムチャネル阻害剤 … More Except Principal Investigator ヒト化マウスモデル / MRGPRX2 / 好塩基球 / 薬剤過敏反応 / アナフィラキシー / ACE2 / サイトカインストーム / 複合体 / キマーゼ / MCP2 / 投与期間 / プレドニゾロン / ケルセチン / マスト細胞 / SARS-CoV-2 Less

胎生期脂質環境による胎児免疫プログラミングと全身エリテマトーデス発症への影響Principal Investigator
- Principal Investigator
  
  劉爽
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ehime University
Unraveling the Mechanisms of Drug Hypersensitivity Reactions and Hypotension: A Multifaceted Study of Basophil MRGPRX2 in Humanized Mice
- Principal Investigator
  
  鈴木康之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Saiseikai Research Institute of Health Care and Welfare
SARS-CoV-2感染におけるマスト細胞の関与と重症化機序解明に向けた研究
- Principal Investigator
  
  茂木正樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ehime University
Profiling efficiency of disease-modifying antirheumatic drugs in cartilage regenerationPrincipal Investigator
- Principal Investigator
  
  Liu Shuang
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ehime University
The efficancy of calcium release-activated calcium channel inhitibors in the treatment of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Liu Shuang
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Ehime University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Rheumatoid Arthritis： Methods and Protocols2018
- Author(s)
  Liu S
- Total Pages
  253
- Publisher
  Springer
- ISBN
  9781493988013
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Mast cells promote viral entry of SARS-CoV-2 via formation of chymase/spike protein complex.2022
- Author(s)
  Shuang Liu, Yasuyuki Suzuki, Erika Takemasa, Ryusuke Watanabe, Masaki Mogi.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 930 Pages: 175169-175169
- DOI
  10.1016/j.ejphar.2022.175169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08564, KAKENHI-PROJECT-21K16549
[Journal Article] Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B32020
- Author(s)
  Sahid MNA, Liu S, Mogi M, Maeyama K
- Journal Title
  
  Inflamm Res
  
  Volume: 69 Issue: 3 Pages: 69289-69298
- DOI
  10.1007/s00011-020-01319-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Denervation‐induced loss of skeletal muscle mass influences immune homeostasis and accelerates the disease progression of lupus nephritis2020
- Author(s)
  Liu S, Kiyoi T, Takemasa E, Mogi M
- Journal Title
  
  JCSM Clinical Reports
  
  Volume: 5 Issue: 4 Pages: 108-120
- DOI
  10.1002/crt2.26
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress2020
- Author(s)
  Kiyoi T, Liu S, Takemasa E, Nakaoka H, Hato N, Mogi M
- Journal Title
  
  PLoS One
  
  Volume: 17 Issue: 4 Pages: e0227582-e0227582
- DOI
  10.1371/journal.pone.0227582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Association between mutated Mas-related G protein-coupled receptor-X2 and rocuronium-induced intraoperative anaphylaxis2020
- Author(s)
  Suzuki Yasuyuki、Liu Shuang、Kadoya Fumito、Takasaki Yasushi、Yorozuya Toshihiro、Mogi Masaki
- Journal Title
  
  British Journal of Anaesthesia
  
  Volume: 125 Issue: 6 Pages: e446-e448
- DOI
  10.1016/j.bja.2020.05.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16541, KAKENHI-PROJECT-18K08389
[Journal Article] Assessment and comparison of the efficacy of methotrexate, prednisolone, adalimumab, and tocilizumab on multipotency of mesenchymal stem cells2020
- Author(s)
  Liu S, Kiyoi T, Ishida M, Mogi M
- Journal Title
  
  Front Pharmacol.
  
  Volume: 11 Pages: 1004-1004
- DOI
  10.3389/fphar.2020.01004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis2020
- Author(s)
  Suzuki Y, Liu S, Ogasawara T, Sawasaki T, Takasaki Y, Yorozuya T, Mogi M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models2019
- Author(s)
  Toyama K, Spin JM, Abe Y, Suzuki Y, Deng AC, Wagenhauser MU, Yoshino T, Mulorz J, Liu S, Tsao PS, Mogi M
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 140 Issue: 1 Pages: 106-108
- DOI
  10.1016/j.jphs.2019.03.007
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP72018
- Author(s)
  Liu Shuang、Sahid Muhammad N.A.、Takemasa Erika、Maeyama Kazutaka、Mogi Masaki
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 151 Pages: 18-25
- DOI
  10.1016/j.bcp.2018.02.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389
[Journal Article] High-throughput screening system for dynamic monitoring of exocytotic vesicle trafficking in mast cells2018
- Author(s)
  Kiyoi Takeshi、Liu Shuang、Sahid Muhammad Novrizal Abdi、Shudou Masachika、Maeyama Kazutaka、Mogi Masaki
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 6 Pages: 1-10
- DOI
  10.1371/journal.pone.0198785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08389
[Journal Article] Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis2018
- Author(s)
  Miyoshi Maya、Liu Shuang、Morizane Asuka、Takemasa Erika、Suzuki Yashuyuki、Kiyoi Takeshi、Maeyama Kazutaka、Mogi Masaki
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 824 Pages: 89-98
- DOI
  10.1016/j.ejphar.2018.02.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389
[Journal Article] Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes2018
- Author(s)
  Suzuki Yasuyuki、Ogasawara Tomio、Tanaka Yuki、Takeda Hiroyuki、Sawasaki Tatsuya、Mogi Masaki、Liu Shuang、Maeyama Kazutaka
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9 Pages: 38-38
- DOI
  10.3389/fphar.2018.00038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389, KAKENHI-PROJECT-16K01915
[Journal Article] Intra-articular lentivirus-mediated gene therapy targeting CRACM1 for the treatment of collagen-induced arthritis2017
- Author(s)
  Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Kazutaka Meayama
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 133 Issue: 3 Pages: 130-138
- DOI
  10.1016/j.jphs.2017.02.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19575
[Journal Article] Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models2017
- Author(s)
  Liu Shuang、Hasegawa Hitoshi、Takemasa Erika、Suzuki Yasuyuki、Oka Keizou、Kiyoi Takeshi、Takeda Hiroyuki、Ogasawara Tomio、Sawasaki Tatsuya、Yasukawa Masaki、Maeyama Kazutaka
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 5 Pages: 1584-1595
- DOI
  10.4049/jimmunol.1700192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01915, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15K19575
[Journal Article] CRAC3 regulates the stability of non-excitable vesicle fusion pores in a Ca2+-independent manner via molecular interaction with syntaxin42016
- Author(s)
  Liu S, Sahid MNA, Takemasa E, Kiyoi T, Kuno M, Oshima Y and Maeyama K
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/srep28133
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08184, KAKENHI-PROJECT-15K19575
[Journal Article] Gene Therapy for Rheumatoid Arthritis2016
- Author(s)
  Liu S, Maeyama K
- Journal Title
  
  Crit Rev. Immunol.　 2016;36(2):149-161.
  
  Volume: 36 Issue: 2 Pages: 149-161
- DOI
  10.1615/critrevimmunol.2016017062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19575
[Journal Article] Systemic Lentivirus-Mediated Delivery of Short Hairpin RNA Targeting Calcium Release-Activated Caclium Channel 3 as Gnen Therapy for Collagen-Induced Arthritis2015
- Author(s)
  Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Kazutaka Meayama
- Journal Title
  
  The Journal of Immunology
  
  Volume: 194 Issue: 1 Pages: 76-83
- DOI
  10.4049/jimmunol.1401976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] Immune system observation in a murine sarcopenic model2020
- Author(s)
  Tomoya Kawanami, Masaki Mogi, Shuang Liu
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] Establishment of a drug screening system for chondrogenic differentiation of mesenchymal stem cells2020
- Author(s)
  Marina Ishida, Shuang Liu, Masaki Mogi
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] Establishment of a drug screening system for chondrogenic differentiation of mesenchymal stem cells.2019
- Author(s)
  Ishida M, Liu S, Mogi M
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] The influence of sarcopenia on immune hemostasis2019
- Author(s)
  Kawanami T, Liu S, Mogi M
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] Down-regulation of intracellualr vesicle trafficking by the treatment of zoledronate in mast cells2018
- Author(s)
  Liu S, Mogi M
- Organizer
  The 18th world congress of basic and clinical pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] Regulation of mutiple differentiation potential in mesenchymal stem cells via an intercellular Ca2+ signaling pathway2018
- Author(s)
  Liu S
- Organizer
  American College of Rheumatology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] Modulation of multiple differetiation potential in mesenchymal stem cells via an intercellula calcium signaling pathway2018
- Author(s)
  Takahashi M, Liu S, Mogi M
- Organizer
  The 18th world congress of basic and clinical pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08389
[Presentation] The inhibition of store-operated Ca2+ entry through calcium release-activated calcium channel in the treatment of rheumatoid arthritis2017
- Author(s)
  劉爽、長谷川均、清井武志、前山一隆
- Organizer
  第90回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] Intra-articular treatment of short hairpin RNA targeting calcium release-activated calcium channel 1 in collagen-induced arthritis mice2017
- Author(s)
  劉爽、清井武志、前山一隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] Chracterization of receptors responsible for basic compound-activation on mast cells: focus on as-related B protein-coupled receptors2016
- Author(s)
  Muhammad Novrizal Abdi Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィッコ横浜(神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] Histamine Uptake Mechanism i mast cells via uptake-2 system transporters: investigation using rat basophilic leukemia subclone (RBL-2H3 Sc98) cells2016
- Author(s)
  Trivadila Trivadila, Muhammad Novrizal Abdi Sahid, Shuang Liu, Kazutaka Maeyama
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィッコ横浜(神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] YM-58483の有効な投与方法と関節炎治療効果の検討2016
- Author(s)
  三好真綾、森実あすか、劉爽、前山一隆
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィッコ横浜(神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] The efficiency of the regulation of Ca2+ entry through calcium release-activated calcium channel in the treatment of rheumatoid arthritis2016
- Author(s)
  Shuang Liu、Erika　Takemasa、Takeshi Kiyoi, Maeyama Kazutaka
- Organizer
  American College of Rheumatology Annual Meeting2016
- Place of Presentation
  Washingtpn D.C.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] The therapeutic effect of YM-58483 on collagen-induced arthritis mice2016
- Author(s)
  Asuka Morizane, Maya Miyoshi, Shuang Liu, Maeyama Kazutaka
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィッコ横浜(神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] Intra-articular treatment of Short Hairpin RNA Targeting Calcium Release-Activated Calcium channel 1 in Collagen-Induced Arthritis mice.2016
- Author(s)
  Shuang Liu、Erika　Takemasa、Takeshi Kiyoi, Maeyama Kazutaka
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィッコ横浜(神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K19575
[Presentation] コラーゲン誘発関節炎モデルマウスにおけるYM-58483による治療効果の検討2015
- Author(s)
  三好真綾、森実あすか、劉爽、前山一隆
- Organizer
  第68回日本薬理学会西南部会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15K19575

1. 茂木正樹 (20363236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 鈴木康之 (10745144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. LI Gunagshuai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 久野みゆき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 竹田浩之

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6. 澤崎達也

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# of Collaborated Products: 1 results

Liu Shuang 劉 爽

Research Projects

Research Products

Co-Researchers

胎生期脂質環境による胎児免疫プログラミングと全身エリテマトーデス発症への影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the Mechanisms of Drug Hypersensitivity Reactions and Hypotension: A Multifaceted Study of Basophil MRGPRX2 in Humanized Mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SARS-CoV-2感染におけるマスト細胞の関与と重症化機序解明に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Profiling efficiency of disease-modifying antirheumatic drugs in cartilage regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The efficancy of calcium release-activated calcium channel inhitibors in the treatment of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Rheumatoid Arthritis： Methods and Protocols2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Mast cells promote viral entry of SARS-CoV-2 via formation of chymase/spike protein complex.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B32020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Denervation‐induced loss of skeletal muscle mass influences immune homeostasis and accelerates the disease progression of lupus nephritis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between mutated Mas-related G protein-coupled receptor-X2 and rocuronium-induced intraoperative anaphylaxis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assessment and comparison of the efficacy of methotrexate, prednisolone, adalimumab, and tocilizumab on multipotency of mesenchymal stem cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis2020

Author(s)

Journal Title

Data Source

[Journal Article] Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP72018

Liu Shuang 劉爽