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Liu Shuang  劉 爽

ORCIDConnect your ORCID iD *help
Researcher Number 60403812
Other IDs
Affiliation (Current) 2025: 愛媛大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 愛媛大学, 医学系研究科, 准教授
2018 – 2020: 愛媛大学, 医学系研究科, 准教授
2016 – 2017: 愛媛大学, 医学系研究科, 講師
2015: 愛媛大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology
Except Principal Investigator
Basic Section 55060:Emergency medicine-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords
Principal Investigator
関節リウマチ / 免疫抑制剤 / ゲノム修飾 / ループス腎炎 / 胎生期脂質環境 / 全身エリテマトーデス / ゲノム編集 / 抗リウマチ薬 / 関節軟骨再生 / 軟骨細胞 … More / 関節再生能 / 異種移植モデル / 軟骨再生 / 免疫抑制薬 / 軟骨移植 / 間葉系幹細胞 / 臨床研究 / 薬理効果 / SCIDマウス / ヒト型関節リウマチモデル / CARCチャネル阻害薬 / Short-hairpin RNA / 核酸製剤 / 抗体製剤 / カルシウムチャネル阻害剤 … More
Except Principal Investigator
ヒト化マウスモデル / MRGPRX2 / 好塩基球 / 薬剤過敏反応 / アナフィラキシー / ACE2 / サイトカインストーム / 複合体 / キマーゼ / MCP2 / 投与期間 / プレドニゾロン / ケルセチン / マスト細胞 / SARS-CoV-2 Less
  • Research Projects

    (5 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (6 People)
  •  胎生期脂質環境による胎児免疫プログラミングと全身エリテマトーデス発症への影響Principal Investigator

    • Principal Investigator
      劉 爽
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Ehime University
  •  Unraveling the Mechanisms of Drug Hypersensitivity Reactions and Hypotension: A Multifaceted Study of Basophil MRGPRX2 in Humanized Mice

    • Principal Investigator
      鈴木 康之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Saiseikai Research Institute of Health Care and Welfare
  •  SARS-CoV-2感染におけるマスト細胞の関与と重症化機序解明に向けた研究

    • Principal Investigator
      茂木 正樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Ehime University
  •  Profiling efficiency of disease-modifying antirheumatic drugs in cartilage regenerationPrincipal Investigator

    • Principal Investigator
      Liu Shuang
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Ehime University
  •  The efficancy of calcium release-activated calcium channel inhitibors in the treatment of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      Liu Shuang
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Ehime University

All 2022 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] Rheumatoid Arthritis: Methods and Protocols2018

    • Author(s)
      Liu S
    • Total Pages
      253
    • Publisher
      Springer
    • ISBN
      9781493988013
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Mast cells promote viral entry of SARS-CoV-2 via formation of chymase/spike protein complex.2022

    • Author(s)
      Shuang Liu, Yasuyuki Suzuki, Erika Takemasa, Ryusuke Watanabe, Masaki Mogi.
    • Journal Title

      European Journal of Pharmacology

      Volume: 930 Pages: 175169-175169

    • DOI

      10.1016/j.ejphar.2022.175169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08564, KAKENHI-PROJECT-21K16549
  • [Journal Article] Tachykinin-1 receptor antagonism suppresses substance-P- and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B32020

    • Author(s)
      Sahid MNA, Liu S, Mogi M, Maeyama K
    • Journal Title

      Inflamm Res

      Volume: 69 Issue: 3 Pages: 69289-69298

    • DOI

      10.1007/s00011-020-01319-z

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Denervation‐induced loss of skeletal muscle mass influences immune homeostasis and accelerates the disease progression of lupus nephritis2020

    • Author(s)
      Liu S, Kiyoi T, Takemasa E, Mogi M
    • Journal Title

      JCSM Clinical Reports

      Volume: 5 Issue: 4 Pages: 108-120

    • DOI

      10.1002/crt2.26

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress2020

    • Author(s)
      Kiyoi T, Liu S, Takemasa E, Nakaoka H, Hato N, Mogi M
    • Journal Title

      PLoS One

      Volume: 17 Issue: 4 Pages: e0227582-e0227582

    • DOI

      10.1371/journal.pone.0227582

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Association between mutated Mas-related G protein-coupled receptor-X2 and rocuronium-induced intraoperative anaphylaxis2020

    • Author(s)
      Suzuki Yasuyuki、Liu Shuang、Kadoya Fumito、Takasaki Yasushi、Yorozuya Toshihiro、Mogi Masaki
    • Journal Title

      British Journal of Anaesthesia

      Volume: 125 Issue: 6 Pages: e446-e448

    • DOI

      10.1016/j.bja.2020.05.046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16541, KAKENHI-PROJECT-18K08389
  • [Journal Article] Assessment and comparison of the efficacy of methotrexate, prednisolone, adalimumab, and tocilizumab on multipotency of mesenchymal stem cells2020

    • Author(s)
      Liu S, Kiyoi T, Ishida M, Mogi M
    • Journal Title

      Front Pharmacol.

      Volume: 11 Pages: 1004-1004

    • DOI

      10.3389/fphar.2020.01004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis2020

    • Author(s)
      Suzuki Y, Liu S, Ogasawara T, Sawasaki T, Takasaki Y, Yorozuya T, Mogi M
    • Journal Title

      Eur J Pharmacol

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models2019

    • Author(s)
      Toyama K, Spin JM, Abe Y, Suzuki Y, Deng AC, Wagenhauser MU, Yoshino T, Mulorz J, Liu S, Tsao PS, Mogi M
    • Journal Title

      J Pharmacol Sci

      Volume: 140 Issue: 1 Pages: 106-108

    • DOI

      10.1016/j.jphs.2019.03.007

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP72018

    • Author(s)
      Liu Shuang、Sahid Muhammad N.A.、Takemasa Erika、Maeyama Kazutaka、Mogi Masaki
    • Journal Title

      Biochem Pharmacol.

      Volume: 151 Pages: 18-25

    • DOI

      10.1016/j.bcp.2018.02.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389
  • [Journal Article] High-throughput screening system for dynamic monitoring of exocytotic vesicle trafficking in mast cells2018

    • Author(s)
      Kiyoi Takeshi、Liu Shuang、Sahid Muhammad Novrizal Abdi、Shudou Masachika、Maeyama Kazutaka、Mogi Masaki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 6 Pages: 1-10

    • DOI

      10.1371/journal.pone.0198785

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Journal Article] Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis2018

    • Author(s)
      Miyoshi Maya、Liu Shuang、Morizane Asuka、Takemasa Erika、Suzuki Yashuyuki、Kiyoi Takeshi、Maeyama Kazutaka、Mogi Masaki
    • Journal Title

      Eur J Pharmacol.

      Volume: 824 Pages: 89-98

    • DOI

      10.1016/j.ejphar.2018.02.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389
  • [Journal Article] Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes2018

    • Author(s)
      Suzuki Yasuyuki、Ogasawara Tomio、Tanaka Yuki、Takeda Hiroyuki、Sawasaki Tatsuya、Mogi Masaki、Liu Shuang、Maeyama Kazutaka
    • Journal Title

      Frontiers in Pharmacology

      Volume: 9 Pages: 38-38

    • DOI

      10.3389/fphar.2018.00038

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15K19575, KAKENHI-PROJECT-18K08389, KAKENHI-PROJECT-16K01915
  • [Journal Article] Intra-articular lentivirus-mediated gene therapy targeting CRACM1 for the treatment of collagen-induced arthritis2017

    • Author(s)
      Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Kazutaka Meayama
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 133 Issue: 3 Pages: 130-138

    • DOI

      10.1016/j.jphs.2017.02.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Journal Article] Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models2017

    • Author(s)
      Liu Shuang、Hasegawa Hitoshi、Takemasa Erika、Suzuki Yasuyuki、Oka Keizou、Kiyoi Takeshi、Takeda Hiroyuki、Ogasawara Tomio、Sawasaki Tatsuya、Yasukawa Masaki、Maeyama Kazutaka
    • Journal Title

      The Journal of Immunology

      Volume: 199 Issue: 5 Pages: 1584-1595

    • DOI

      10.4049/jimmunol.1700192

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01915, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-15K19575
  • [Journal Article] CRAC3 regulates the stability of non-excitable vesicle fusion pores in a Ca2+-independent manner via molecular interaction with syntaxin42016

    • Author(s)
      Liu S, Sahid MNA, Takemasa E, Kiyoi T, Kuno M, Oshima Y and Maeyama K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/srep28133

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08184, KAKENHI-PROJECT-15K19575
  • [Journal Article] Gene Therapy for Rheumatoid Arthritis2016

    • Author(s)
      Liu S, Maeyama K
    • Journal Title

      Crit Rev. Immunol.  2016;36(2):149-161.

      Volume: 36 Issue: 2 Pages: 149-161

    • DOI

      10.1615/critrevimmunol.2016017062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Journal Article] Systemic Lentivirus-Mediated Delivery of Short Hairpin RNA Targeting Calcium Release-Activated Caclium Channel 3 as Gnen Therapy for Collagen-Induced Arthritis2015

    • Author(s)
      Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Kazutaka Meayama
    • Journal Title

      The Journal of Immunology

      Volume: 194 Issue: 1 Pages: 76-83

    • DOI

      10.4049/jimmunol.1401976

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] Immune system observation in a murine sarcopenic model2020

    • Author(s)
      Tomoya Kawanami, Masaki Mogi, Shuang Liu
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] Establishment of a drug screening system for chondrogenic differentiation of mesenchymal stem cells2020

    • Author(s)
      Marina Ishida, Shuang Liu, Masaki Mogi
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] Establishment of a drug screening system for chondrogenic differentiation of mesenchymal stem cells.2019

    • Author(s)
      Ishida M, Liu S, Mogi M
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] The influence of sarcopenia on immune hemostasis2019

    • Author(s)
      Kawanami T, Liu S, Mogi M
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] Down-regulation of intracellualr vesicle trafficking by the treatment of zoledronate in mast cells2018

    • Author(s)
      Liu S, Mogi M
    • Organizer
      The 18th world congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] Regulation of mutiple differentiation potential in mesenchymal stem cells via an intercellular Ca2+ signaling pathway2018

    • Author(s)
      Liu S
    • Organizer
      American College of Rheumatology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] Modulation of multiple differetiation potential in mesenchymal stem cells via an intercellula calcium signaling pathway2018

    • Author(s)
      Takahashi M, Liu S, Mogi M
    • Organizer
      The 18th world congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08389
  • [Presentation] The inhibition of store-operated Ca2+ entry through calcium release-activated calcium channel in the treatment of rheumatoid arthritis2017

    • Author(s)
      劉爽、長谷川均、清井武志、前山一隆
    • Organizer
      第90回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] Intra-articular treatment of short hairpin RNA targeting calcium release-activated calcium channel 1 in collagen-induced arthritis mice2017

    • Author(s)
      劉爽、清井武志、前山一隆
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] Chracterization of receptors responsible for basic compound-activation on mast cells: focus on as-related B protein-coupled receptors2016

    • Author(s)
      Muhammad Novrizal Abdi Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] Histamine Uptake Mechanism i mast cells via uptake-2 system transporters: investigation using rat basophilic leukemia subclone (RBL-2H3 Sc98) cells2016

    • Author(s)
      Trivadila Trivadila, Muhammad Novrizal Abdi Sahid, Shuang Liu, Kazutaka Maeyama
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] YM-58483の有効な投与方法と関節炎治療効果の検討2016

    • Author(s)
      三好真綾、森実あすか、劉爽、前山一隆
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] The efficiency of the regulation of Ca2+ entry through calcium release-activated calcium channel in the treatment of rheumatoid arthritis2016

    • Author(s)
      Shuang Liu、Erika Takemasa、Takeshi Kiyoi, Maeyama Kazutaka
    • Organizer
      American College of Rheumatology Annual Meeting2016
    • Place of Presentation
      Washingtpn D.C.
    • Year and Date
      2016-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] The therapeutic effect of YM-58483 on collagen-induced arthritis mice2016

    • Author(s)
      Asuka Morizane, Maya Miyoshi, Shuang Liu, Maeyama Kazutaka
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] Intra-articular treatment of Short Hairpin RNA Targeting Calcium Release-Activated Calcium channel 1 in Collagen-Induced Arthritis mice.2016

    • Author(s)
      Shuang Liu、Erika Takemasa、Takeshi Kiyoi, Maeyama Kazutaka
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィッコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K19575
  • [Presentation] コラーゲン誘発関節炎モデルマウスにおけるYM-58483による治療効果の検討2015

    • Author(s)
      三好真綾、森実あすか、劉爽、前山一隆
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15K19575
  • 1.  茂木 正樹 (20363236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  鈴木 康之 (10745144)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  LI Gunagshuai
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  久野 みゆき
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  竹田 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  澤崎 達也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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