Endo Satoshi 遠藤智史

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ENDO Satoshi 遠藤智史

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Researcher Number	60433207
Other IDs	https://orcid.org/0000-0003-0578-9672
Affiliation (Current)	2026: 岐阜大学, 大学院連合創薬医療情報研究科, 准教授 2026: 岐阜薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 岐阜大学, 大学院連合創薬医療情報研究科, 准教授 2019 – 2023: 岐阜薬科大学, 薬学部, 准教授 2017 – 2018: 岐阜薬科大学, 薬学部, 講師 2010 – 2017: 岐阜薬科大学, 薬学部, 助教 2007 – 2009: Gifu Pharmaceutical University, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 37030:Chemical biology-related / Urology / General pharmacology / Biological pharmacy Except Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 構造活性相関 / 抗がん剤耐性 / 抗癌剤耐性克服 / 抗癌剤 / AKR1B10 / アルドケト還元酵素 / アルドーケト還元酵素 / プロテオスタシス / アミロイド線維 / リソソーム … More / 阻害剤創製 / 泌尿器がん / 去勢抵抗性前立腺がん / Atg4B / がん / オートファジー阻害剤 / 前立腺がん / オートファジー / 創薬科学 / Nrf2 / 抗癌剤耐性化 / アパルタミド / AKR1C3 / 去勢抵抗性前立腺癌 / 阻害選択性の向上 / 構造安定性低下 / SNPs / 分子モデリング / SNP / 制癌薬 / 抗癌剤耐性抑制薬 / aldo-keto reductases / 癌 / イソプレノイド / 酵素 / 構造機能相関 / 9,10-phenanthrenequinone / 酸化ストレス / カルボニルストレス / カルボニル還元酵素 … More Except Principal Investigator LC3-GST cleavage assay / システインプロテアーゼ / 構造―活性相関 / in silicoスクリーニング / Atg4B阻害剤 / オートファジー阻害剤 / Atg4B / オートファゴソーム / オートファジー / バイオマーカー / クローディン / 細胞局在 / Mgチャネル / 低Mg血症 / 医薬品設計 / アルドース還元酵素 / 高次構造 / 阻害剤 / 抗癌剤耐性 / 制癌剤 / アルドーケト還元酵素 / ヒドロキシステロイド脱水素酵素 / 医薬品化学・医薬分子設計 Less

アミロイド線維の戦略的蓄積による画期的がん治療戦略の確立Principal Investigator
- Principal Investigator
  
  遠藤智史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gifu University
Research and development of autophagy-specific inhibitors
- Principal Investigator
  
  豊岡尚樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Toyama
Reconsidering the significance of autophagy in urological cancer and drug discoveryPrincipal Investigator
- Principal Investigator
  
  Endo Satoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Gifu Pharmaceutical University
Development of a multi-targeted castration-resistant prostate cancer drug for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Endo Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Gifu Pharmaceutical University
Establishment of the basis for evolutional drug development toward avoidance of hypomagnesemia
- Principal Investigator
  
  IKARI AKIRA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Development of novel anticancer agents targeting survival strategy of cancer cellsPrincipal Investigator
- Principal Investigator
  
  Endo Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Development of novel anticancer drugs targeting for controlling the function and expression of oxidative stress-induced proteinPrincipal Investigator
- Principal Investigator
  
  ENDO Satoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
DEVELOPMENT OF ANTITUMOR DRUGS TARGETING TUMOR MARKERALDO-KETO REDUCTASES
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Development of antitumor agents targeting for prenoid-metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  ENDO Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Gifu Pharmaceutical University
Elucidation of defense mechanism against carbonyl stress by reductases for carbonyl compoundsPrincipal Investigator
- Principal Investigator
  
  ENDO Satoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University

[Journal Article] Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells2023
- Author(s)
  Ota Atsumi、Kawai Mina、Kudo Yudai、Segawa Jin、Hoshi Manami、Kawano Shinya、Yoshino Yuta、Ichihara Kenji、Shiota Masaki、Fujimoto Naohiro、Matsunaga Toshiyuki、Endo Satoshi、Ikari Akira
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 735 Pages: 109519-109519
- DOI
  10.1016/j.abb.2023.109519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05751
[Journal Article] Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer2022
- Author(s)
  Kudo Yudai、Endo Satoshi、Fujita Mei、Ota Atsumi、Kamatari Yuji O.、Tanaka Yoshimasa、Ishikawa Takeshi、Ikeda Hayato、Okada Takuya、Toyooka Naoki、Fujimoto Naohiro、Matsunaga Toshiyuki、Ikari Akira
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 6 Pages: 4878-4892
- DOI
  10.1021/acs.jmedchem.1c02113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K12129, KAKENHI-PROJECT-20K05751, KAKENHI-PROJECT-20H04285
[Journal Article] Correction to “Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer”2022
- Author(s)
  Kudo Yudai、Endo Satoshi、Fujita Mei、Ota Atsumi、Kamatari Yuji O.、Tanaka Yoshimasa、Ishikawa Takeshi、Ikeda Hayato、Okada Takuya、Toyooka Naoki、Fujimoto Naohiro、Matsunaga Toshiyuki、Ikari Akira
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 11 Pages: 8062-8063
- DOI
  10.1021/acs.jmedchem.2c00749
- Data Source
  KAKENHI-PROJECT-20K05751
[Journal Article] Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells.2021
- Author(s)
  Satoshi Endo, Mina Kawai, Manami Hoshi, Jin Segawa, Mei Fujita, Takuo Matsukawa, Naohiro Fujimoto, Toshiyuki Matsunaga, Akira Ikari
- Journal Title
  
  Journal of Biochemistry
  
  Volume: － Issue: 1 Pages: 89-96
- DOI
  10.1093/jb/mvab025
- NAID
  40022721819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05751
[Journal Article] Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids2020
- Author(s)
  Endo Satoshi、Morikawa Yoshifumi、Kudo Yudai、Suenami Koichi、Matsunaga Toshiyuki、Ikari Akira、Hara Akira
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 199 Pages: 105586-105586
- DOI
  10.1016/j.jsbmb.2020.105586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11151
[Journal Article] Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS112019
- Author(s)
  Endo Satoshi、Miyagi Namiki、Matsunaga Toshiyuki、Ikari Akira
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 305 Pages: 12-20
- DOI
  10.1016/j.cbi.2019.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11151
[Journal Article] Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models2018
- Author(s)
  Maruhashi Ryohei、Akizuki Risa、Sato Tomonari、Matsunaga Toshiyuki、Endo Satoshi、Yamaguchi Masahiko、Yamazaki Yasuhiro、Sakai Hideki、Ikari Akira
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1865 Issue: 3 Pages: 470-479
- DOI
  10.1016/j.bbamcr.2017.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-17H05030
[Journal Article] Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells2018
- Author(s)
  Sonoki Hiroyuki、Tanimae Asami、Furuta Takumi、Endo Satoshi、Matsunaga Toshiyuki、Ichihara Kenji、Ikari Akira
- Journal Title
  
  Journal of Nutritional Biochemistry
  
  Volume: 56 Pages: 205-214
- DOI
  10.1016/j.jnutbio.2018.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells2018
- Author(s)
  Akizuki Risa、Maruhashi Ryohei、Eguchi Hiroaki、Kitabatake Kazuki、Tsukimoto Mitsutoshi、Furuta Takumi、Matsunaga Toshiyuki、Endo Satoshi、Ikari Akira
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1865 Issue: 5 Pages: 769-780
- DOI
  10.1016/j.bbamcr.2018.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Chlorpheniramine Increases Paracellular Permeability to Marker Fluorescein Lucifer Yellow Mediated by Internalization of Occludin in Murine Colonic Epithelial Cells2017
- Author(s)
  Manabe Aya、Furukawa Chisa、Endo Satoshi、Marunaka Kana、Nishiyama Tsubasa、Fujii Naoko、Tabuchi Yoshiaki、Matsunaga Toshiyuki、Ikari Akira
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 8 Pages: 1299-1305
- DOI
  10.1248/bpb.b17-00244
- NAID
  130005876269
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Down-regulation of claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells2017
- Author(s)
  Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, Ikari A
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 6 Pages: 2411-2421
- DOI
  10.1074/jbc.m116.762807
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma2017
- Author(s)
  Akizuki R, Shimobaba S, Matsunaga T, Endo S, Ikari A
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1864 Issue: 2 Pages: 293-302
- DOI
  10.1016/j.bbamcr.2016.11.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells2017
- Author(s)
  Sonoki Hiroyuki、Tanimae Asami、Endo Satoshi、Matsunaga Toshiyuki、Furuta Takumi、Ichihara Kenji、Ikari Akira
- Journal Title
  
  Nutrients
  
  Volume: 9 Issue: 6 Pages: 597-597
- DOI
  10.3390/nu9060597
- NAID
  120006333890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Fatty Acids and CoA Derivatives as Inhibitors of Human Carbonyl Reductase 12017
- Author(s)
  Akira Hara, Satoshi Endo, Toshiyuki Matsunaga, Ossama El-Kabbani, Takeshi Miura, Toru Nishinaka and Tomoyuki Terada
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 印刷中 Pages: 185-192
- DOI
  10.1016/j.bcp.2017.04.023
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460149
[Journal Article] Instability of C154Y variant of aldo-keto reductase 10.1038/s41598-017-00710-x1C32017
- Author(s)
  Satoshi Endo, Sayaka Takada, Ryo P. Honda, Kathrin Muller, Jochen H. Weishaupt, Peter M. Andersen, Albert C. Ludolph, Yuji O. Kamatari, Toshiyuki Matsunaga, Kazuo Kuwata, Ossama El-Kabbani, Akira Ikari
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: S0009-2797(16) Pages: 194-202
- DOI
  10.1016/j.cbi.2016.12.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011, KAKENHI-PROJECT-26460149, KAKENHI-PROJECT-15K07024
[Journal Article] The RING finger- and PDZ domain-containing protein PDZRN3 controls localization of the Mg2+ regulator claudin-16 in renal tube epithelial cells.2017
- Author(s)
  Marunaka Kana、Furukawa Chisa、Fujii Naoko、Kimura Toru、Furuta Takumi、Matsunaga Toshiyuki、Endo Satoshi、Hasegawa Hajime、Anzai Naohiko、Yamazaki Yasuhiro、Yamaguchi Masahiko、Ikari Akira
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 31 Pages: 13034-13044
- DOI
  10.1074/jbc.m117.779405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-17H05030
[Journal Article] Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets2017
- Author(s)
  Furukawa Chisa、Ishizuka Noriko、Hayashi Hisayoshi、Fujii Naoko、Manabe Aya、Tabuchi Yoshiaki、Matsunaga Toshiyuki、Endo Satoshi、Ikari Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-12494-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04657
[Journal Article] Up-regulation of transient receptor potential melastatin 6 channel expression by tumor necrosis factor-α in the presence of epidermal growth factor receptor tyrosine kinase inhibitor2016
- Author(s)
  Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, Ito Y, Yamaguchi M, Yamazaki Y, Ikari A
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 印刷中 Issue: 10 Pages: 2841-2850
- DOI
  10.1002/jcp.25709
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-17H05030
[Journal Article] Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells2016
- Author(s)
  Shun Shimobaba, Saeko Taga, Risa Akizuki, Asami Hichino, Satoshi Endo, Toshiyuki Matsunaga, Ryo Watanabe, Masahiko Yamaguchi, Yasuhiro Yamazaki, Junko Sugatani, Akira Ikari
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1863 Issue: 6 Pages: 1170-1178
- DOI
  10.1016/j.bbamcr.2016.02.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-26860041
[Journal Article] Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells2016
- Author(s)
  Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 47 Pages: 24787-24799
- DOI
  10.1074/jbc.m116.728196
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-15K15029, KAKENHI-PROJECT-26860041
[Journal Article] Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.2015
- Author(s)
  Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1848 Issue: 10 Pages: 2326-2336
- DOI
  10.1016/j.bbamem.2015.07.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15029, KAKENHI-PROJECT-15H04657, KAKENHI-PROJECT-25293047
[Journal Article] Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily2015
- Author(s)
  Satoshi Endo, Misato Noda, Akira Ikari, Ossama El-Kabbani, Akira Hara and Toshiyuki Matsunaga
- Journal Title
  
  J. Biochem.
  
  Volume: 158 Pages: 425-434
- NAID
  40020647066
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460149
[Journal Article] Structure-activity relationships of flavonoids for carbonyl reductase 1 (CBR1) inhibition2015
- Author(s)
  Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. and Ikari, A.
- Journal Title
  
  Fitoterapia
  
  Volume: 101 Pages: 51-56
- DOI
  10.1016/j.fitote.2014.12.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460149
[Journal Article] Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 12015
- Author(s)
  Dawei Hu, Namiki Miyagi, Yuki Arai, Hiroaki Oguri, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Hiroaki Gouda, Ossama El-Kabbani, Shuang, Xia, Naoki Toyooka, Akira Hara, Toshiyuki Matsunaga, Akira Ikari, Satoshi Endo
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Pages: 7487-7499
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460149
[Journal Article] Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Their relationship with multiple forms of drug ketone reductases2014
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Yuki Arai, Kazuo Tajima, Ossama El-Kabbani, Shigeru Yamano, Yasuo Bunai, Akira Hara, Yukio Kitade
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 42 Issue: 4 Pages: 803-812
- DOI
  10.1124/dmd.113.056044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114
[Journal Article] Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for AKR1B102013
- Author(s)
  Satoshi Endo, Dawei HU, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, Naoki Toyooka
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21(21) Issue: 21 Pages: 6378-6384
- DOI
  10.1016/j.bmc.2013.08.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24790114, KAKENHI-PROJECT-25460068
[Journal Article] Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents2013
- Author(s)
  Satoshi Endo
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 202 Issue: 1-3 Pages: 146-152
- DOI
  10.1016/j.cbi.2012.11.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570044, KAKENHI-PROJECT-22790074, KAKENHI-PROJECT-24790114
[Journal Article] Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds2013
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Atsuko Matsumoto, Yuki Arai, Satoshi Ohno, Ossama El-Kabbani, Kazuo Tajima, Yukio Kitade, Yasuo Bunai, Shigeru Yamano, and Akira Hara
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 86 Issue: 9 Pages: 1366-1375
- DOI
  10.1016/j.bcp.2013.08.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114, KAKENHI-PROJECT-25460068
[Journal Article] Characterization of a rabbit morphine 6-dehydrogenase and its two isoforms which function as NAD+-dependent 3α(17β)- hydroxysteroid dehydrogenases2012
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Airi Fujimoto, Sho Kumada, Yuki Arai, Yoko Miura, Hiroshige Mikamo, Ossama El-Kabbani, Shigeru Yamano, Munekazu Iinuma, Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys
  
  Volume: Vol.529、No.2 Issue: 2 Pages: 131-139
- DOI
  10.1016/j.abb.2012.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114
[Journal Article] Inhibition of Human Aldose Reductase-like Protein (AKR1B10) byα- andγ-Mangostins, Major Components of Pericarps of Mangosteen、Biol2012
- Author(s)
  Midori Soda, Satoshi Endo, Toshiyuki Matsunaga, Hai-Tao Zhao, Ossama El-Kabbani, Munekazu Iinuma, Keiko Yamamura, and Akira Hara
- Journal Title
  
  Pharm. Bull.
  
  Volume: Vol.35、No.11 Pages: 2075-2080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114
[Journal Article] Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B102012
- Author(s)
  Soda M, Hu D, Endo S,他
- Journal Title
  
  Eur. J. Med.Chem.
  
  Volume: 48 Pages: 321-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis2012
- Author(s)
  Endo S, Matsunaga T,他
- Journal Title
  
  J. Nat. Prod
  
  Volume: 75 Pages: 716-721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers2012
- Author(s)
  Matsunaga T, Hojo A, Yamane Y, Endo S, El-Kabbani O, Hara A
- Journal Title
  
  Chem. Biol. Interact
  
  Volume: 202 Issue: 1-3 Pages: 234-242
- DOI
  10.1016/j.cbi.2012.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Aldo-keto reductase 1B10 and its role in proliferation capacity of drug-resistant cancers2012
- Author(s)
  Matsunaga T, Wada Y, Endo S, Soda M, El-Kabbani O, Hara A
- Journal Title
  
  Front. Pharmacol
  
  Volume: 3 Pages: 5-11
- DOI
  10.3389/fphar.2012.00005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Design, syn thesis and evaluation of caffeic ac id phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B102012
- Author(s)
  Midori Soda, Dawei Hu, Satoshi Endo, Mayuko Takemura, Jie Li, Ryogo Wa da, Syohei Ifuku, Hai-Tao Zhao, Oss ama El-Kabbani, Shozo Ohta, Keiko Y amamura, Naoki Toyooka, Akira Hara, and Toshiyuki Matsunaga
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 48 Pages: 321-329
- DOI
  10.1016/j.ejmech.2011.12.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Inhibition of Human Aldose Reductase-Like Protein (AKR1B10) by α- and γ-Mangostins, Major Components of Pericarps of Mangosteen2012
- Author(s)
  Soda M, Endo S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 11 Pages: 2075-2080
- DOI
  10.1248/bpb.b12-00538
- NAID
  130001872266
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Inhibition of Human Aldose Reductase-like Protein (AKR1B10) by α- and γ-Mangostins, Major Components of Pericarps of Mangosteen2012
- Author(s)
  Midori Soda, Satoshi Endo, Toshiyuki Matsunaga, Hai-Tao Zhao, Ossama El-Kabbani, Munekazu Iinuma, Keiko Yamamura, and Akira Hara
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 2075-2080
- NAID
  130001872266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114
[Journal Article] Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase(AKR1C3) by bacchari n, a component of brazilian propolis2012
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Ayano Kanamori, Youko Otsuji, Hirok o Nagai, Krithika Sundaram, Ossama El-Kabbani, Naoki Toyooka, Shozo O hta and A kira
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 75 Issue: 4 Pages: 716-721
- DOI
  10.1021/np201002x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol2011
- Author(s)
  Endo S, Matsunaga T, 他
- Journal Title
  
  Chem. Biol. Interact
  
  Volume: 191 Pages: 261-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Roles of rat and human aldo-k eto reductases in metabolism of farne sol and geranylgeraniol2011
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Ch isato Ohta, Midori Soda, Ayano Kanam ori, Yukio Kitade, Satoshi Ohno, Kaz uo Tajima, Ossama El-Kabbani and Akir a Hara
- Journal Title
  
  Chem. Biol. Interact.
  
  Volume: 191 Issue: 1-3 Pages: 261-268
- DOI
  10.1016/j.cbi.2010.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Probing the Inhi bitor Selectivity Pocket of Human 20α-Hydroxysteroid Dehydrogenase(AKR1 C1) with X-Ray Crystallography and Si te-Directed Mutagenesis2011
- Author(s)
  Ossama El-Kabbani, Urmi Dhagat, Midor i Soda, Satoshi Endo, Toshiyuki Matsu naga and Akira Hara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Issue: 8 Pages: 2564-2567
- DOI
  10.1016/j.bmcl.2011.01.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102
[Journal Article] Sele ctive Inhibition of the Tumor Marker Aldo-keto Reductase Family Member 1B1 0 by Oleanolic Acid2011
- Author(s)
  Mayuko Takemura, Satoshi Endo, Toshiy uki Matsunaga, Midori Soda, Hai-Tao Zhao, Ossama El-Kabbani, Kazuo Tajima, Munekazu Iimuma, and Akira Hara
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 74 Issue: 5 Pages: 1201-1206
- DOI
  10.1021/np200118q
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B102010
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Kazuo Kuwata, Hai-Tao Zhao, Ossama El-Kabbani, Yukio Kitade and Akira Hara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 18 Issue: 7 Pages: 2485-2490
- DOI
  10.1016/j.bmc.2010.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Selective inhibition of the tumor marker AKR1B10 by anti-inflammatory N-phenylanthranilic acids and glycyrrhetic acid.2010
- Author(s)
  S.Endo, 他6名
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 33 Pages: 886-890
- NAID
  130000248053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Selectivity Determinants of Inhibitor Binding to the Tumour Marker Human Aldose Reductase-Like Protein(AKR1B10) Discovered from Molecular Docking and Database Screening2010
- Author(s)
  Hi-Tai Zhao, Midori Soda, Satoshi Endo, Akira Hara, Ossama El-Kabbani
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 45 Issue: 9 Pages: 4354-4357
- DOI
  10.1016/j.ejmech.2010.05.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Chromene-3-carboxamide derivatives discovered from virtual screening as -potent inhibitors of the tumour maker, AKR1B102010
- Author(s)
  Satoshi Endo
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 2010-2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Selective Inhibition of the Tumor Marker AKR1B10 by Antiinflammatory N-Phenylanthranilic Acids and Glycyrrhetic Acid2010
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Midori Soda, Kazuo Tajima, Hi-Tai Zhao, Ossama, El-Kabbani and Akira Hara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 33 Issue: 5 Pages: 886-890
- DOI
  10.1248/bpb.33.886
- NAID
  130000248053
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102
[Journal Article] Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)α-hydroxysteroid dehydrogenase (AKR1C21)2010
- Author(s)
  U.Dhagat, S.Endo, H.Mamiya, A.Hara, O.El-Kabbani
- Journal Title
  
  Acta Crystallogr.D Biol.Crystallogr.
  
  Volume: 66 Pages: 198-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Selective Inhibition of the Tumor Marker AKR1B10 by Antiinflammatory N-Phenylanthranilic Acids and Glycyrrhetic Acid.2010
- Author(s)
  Satoshi Endo
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33 Pages: 886-890
- NAID
  130000248053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Factorizing the role of a critical leucine residue in the binding of substrate to human 20α-hydroxysteroid dehydrogenase (AKR1C1).2010
- Author(s)
  U.Dhagat, S.Endo, M.Soda, A.Hara, O.El-Kabbani
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 5274-5276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin : Probing the active site of the enzyme with molecular modeling and site-directed mutagenesis2009
- Author(s)
  Toshiyuki Matsunaga, Satoshi Endo, Midori Soda, Hai-Tao Zhao, Ossama El-Kabbani, Kazuo Tajima, Akira Hara
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 389 Issue: 1 Pages: 128-132
- DOI
  10.1016/j.bbrc.2009.08.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress.2009
- Author(s)
  Satoshi Endo
- Journal Title
  
  Chem. Biol. Interact. 176
  
  Pages: 151-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Structure-Guided Design, Synthesis and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20α-Hydroxysteroid Dehydrogen ase(AKR1C1)2009
- Author(s)
  Ossama El-Kabbani, Peter J. Scammells, Joshua Gosling, Urmi Dhagat, Satoshi Endo, Toshiyuki Matsunaga, Midori Soda and Akira Hara
- Journal Title
  
  J. Med. Chem.
  
  Volume: 52 Issue: 10 Pages: 3259-3264
- DOI
  10.1021/jm9001633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress2009
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Hiroaki Mamiya, Akira Hara, Yukio Kitade, Kazuo Tajima, Ossama El-Kabbani
- Journal Title
  
  Chem. Biol. Interact 176
  
  Pages: 151-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Kinetic studies of AKR1B10, human aldose reductase-like protein: Endo genous substrates and inhibition by steroids2009
- Author(s)
  Satoshi Endo
- Journal Title
  
  Arch.Biochem.Biophys. 487
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Kinetic studies of AKR1B10, human aldose reductase-like protein : Endogenous substrates and inhibition by steroids、Arch2009
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Hiroaki Mamiya, Chisato Ohta, Midori Soda, Yukio Kitade, Kazuo Tajima, Hai-Tao Zhao, Ossama El-Kabbani, Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys.
  
  Volume: 487 Issue: 1 Pages: 1-9
- DOI
  10.1016/j.abb.2009.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245
[Journal Article] Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity2008
- Author(s)
  Toshiyuki Matsunaga, Satoshi Endo, Satoshi Maeda , Shuhei Ishikura, Kazuo Tajima, Nobutada Tanaka, Kazuo TNakamura, Yorishige Imamura, and Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys 477
  
  Pages: 339-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase2008
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Yukio Kitade, Satoshi Ohno, Kazuo Tajima, Ossama El-Kabbani and Akira Hara
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 1326-1330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase.2008
- Author(s)
  Satoshi Endo
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 1326-1330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Enzymatic Characteristics of an Aldo-Keto Reductase Family Protein(AKR1C15)and its Localization in Rat Tissues2007
- Author(s)
  Satoshi Endo
- Journal Title
  
  Arch. Biochem. Biophys. 465
  
  Pages: 136-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Enzymatic characteristics of an aldo-keto reductase family protein(AKR1C15) and its localization in rat tissues2007
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Kenji Horie, Kazuo Tajima, Yasuo Bunai, Vincenzo Carbone, Ossama El-Kabbani, Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys 465
  
  Pages: 136-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis2007
- Author(s)
  Satoshi Endo, Masaharu Sanai, Kenji Horie, Toshiyuki Matsunaga, Syuhei Ishikura, KazuoTajima, Ossama El-Kabbani, and Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys 467
  
  Pages: 76-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): A member of the aldo-keto reductase family highly expressed in kidney cytosol2007
- Author(s)
  Masaharu Sanai, Satoshi Endo, Toshiyuki Matsunaga, Shuhei Ishikura, Kazuo Tajima, Ossama El-Kabbani and Akira Hara
- Journal Title
  
  Arch. Biochem. Biophys 464
  
  Pages: 122-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Journal Article] Characterization of rat and mouse NAD+-dependent 3α/17β/20α-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis2007
- Author(s)
  Satoshi Endo
- Journal Title
  
  Arch. Biochem. Biophys. 467
  
  Pages: 76-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890180
[Patent] オートファジー阻害剤2020
- Inventor(s)
  遠藤智史、五十里彰、豊岡尚樹、岡田卓哉、藤本直浩
- Industrial Property Rights Holder
  遠藤智史、五十里彰、豊岡尚樹、岡田卓哉、藤本直浩
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K05751
[Patent] AKR1C3選択的阻害剤及びその用途2018
- Inventor(s)
  遠藤智史、松永俊之、五十里彰、豊岡尚樹、藤本直浩
- Industrial Property Rights Holder
  岐阜市、富山大学、産業医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K11151
[Patent] AKR1B10阻害に基づく肺癌治療薬2016
- Inventor(s)
  遠藤智史、松永俊之、五十里彰、豊岡尚樹、早川芳弘
- Industrial Property Rights Holder
  岐阜市、富山大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-08-15
- Data Source
  KAKENHI-PROJECT-26460149
[Patent] AKR1C3阻害剤2013
- Inventor(s)
  遠藤智史、松永俊之、豊岡尚樹
- Industrial Property Rights Holder
  岐阜市
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-149089
- Filing Date
  2013-07-18
- Data Source
  KAKENHI-PROJECT-24790114
[Patent] AKR1C3阻害剤2013
- Inventor(s)
  遠藤智史、松永俊之、豊岡尚樹
- Industrial Property Rights Holder
  岐阜市
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-149089
- Filing Date
  2013-07-18
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] Design of specific autophagy inhibitors for use as anti-cancer drug2025
- Author(s)
  Nao Kobayashi, Mao Ogino, Yudai Kudo, Yuta Yoshino, Akira Ikari, Takuya Okada, Satoshi Endo, Naoki Toyooka
- Organizer
  The 21st Annual Congress of International Drug Discovery Science and Technology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06024
[Presentation] 抗がん剤への応用を目指したオートファジー特異的阻害剤の化合物デザイン2024
- Author(s)
  小林奈央、荻野真生、工藤優大、吉野雄太、五十里彰、岡田卓哉、遠藤智史、豊岡尚樹
- Organizer
  第41回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06024
[Presentation] 前立腺がん治療の改善を目指した特異的オートファジー阻害剤の開発研究2024
- Author(s)
  荻野真生, 小林奈央, 工藤優大, 吉野雄太, 五十里彰, 岡田卓哉, 遠藤智史, 豊岡尚樹
- Organizer
  有機合成化学北陸セミナー
- Data Source
  KAKENHI-PROJECT-23K06024
[Presentation] 抗がん剤耐性克服に向けた新規治療戦略の確立2024
- Author(s)
  遠藤智史
- Organizer
  2024年度One Medicine創薬シーズ開発・育成研究教育拠点シンポジウム
- Data Source
  KAKENHI-PROJECT-24K09816
[Presentation] オートファジーを標的とした抗がん剤耐性膵臓がん治療戦略の開発2023
- Author(s)
  工藤　優大、坂　智文、都築　歩乃佳、吉野　雄太、岡田　卓哉、豊岡　尚樹、遠藤　智史、五
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 膵がんの抗がん剤耐性克服を目指した新規オートファジー阻害剤の開発2023
- Author(s)
  工藤優大，廣田光太郎，都築歩乃佳，吉野雄太，小林奈央, 岡田卓哉，豊岡尚樹，遠藤智史，五十里彰
- Organizer
  第４０回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06024
[Presentation] インシリコ技術を活用した新規機能性分子の開発2023
- Author(s)
  遠藤　智史
- Organizer
  第3回岐阜創薬・医療機器開発フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 前立腺がん治療の改善を目指した新規オートファジー特異的阻害剤の創製2023
- Author(s)
  小林奈央, 工藤優大, 藤田芽衣, 吉野雄太, 松永俊之, 五十里彰, 遠藤智史, 岡田卓哉, 豊岡尚樹
- Organizer
  第４０回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K06024
[Presentation] オートファゴソーム膜の形成を作用点とする新規オートファジー阻害剤の開発2022
- Author(s)
  工藤　優大、藤田　芽衣、吉野　雄太、鎌足　雄司、田中　義正、石川　岳志、藤本　直浩、岡田　卓哉、豊岡　尚樹、遠藤　智史、
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 論理的創薬による新規オートファジー阻害剤の創製2022
- Author(s)
  遠藤　智史
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2
- Invited
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] がんアジュバント薬の開発を指向したオートファジー阻害剤の創製研究2022
- Author(s)
  工藤　優大、藤田　芽衣、吉野　雄太、鎌足　雄司、田中　義正、石川　岳志、藤本　直浩、岡田　卓哉、豊岡　尚樹、遠藤　智史
- Organizer
  第21回次世代を担う若手のためのファーマ・バイオフォーラム2022
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] インシリコ技術を活用した新規機能性分子の開発2022
- Author(s)
  遠藤　智史
- Organizer
  第3回岐阜創薬・医療機器開発フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] オートファゴソーム膜の形成を作用点とする新規オートファジー阻害剤の開発2022
- Author(s)
  工藤　優大、藤田　芽衣、吉野　雄太、鎌足　雄司、田中　義正、石川　岳志、藤本　直浩、岡田　卓哉、豊岡　尚樹、遠藤　智史、五十里　彰
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 論理的創薬による新規オートファジー阻害剤の創製2022
- Author(s)
  遠藤　智史
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
- Invited
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 必須脂肪酸によるAtg4B阻害を介した抗がん剤感受性増強効果2022
- Author(s)
  中村　香菜、工藤　優大、吉野　雄太、中村　光浩、藤本　直浩、高谷　大輔、本間　光貴、遠藤　智史、五十里　彰
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] オートファゴソーム膜形成を標的とした新規オートファジー阻害剤の開発2021
- Author(s)
  遠藤　智史
- Organizer
  岐阜大学大学院連合創薬医療情報研究科　2021公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 前立腺癌治療薬としての新規オートファジー阻害剤の有効性の検証2021
- Author(s)
  工藤　優大、藤田　芽衣、鎌足　雄司、田中　義正、藤本　直浩、岡田　卓哉、豊岡　尚樹、五十里　彰、遠藤　智史
- Organizer
  第85回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] オートファジー阻害剤としての新規Atg4B阻害剤の創製2021
- Author(s)
  工藤　優大、藤田　芽衣、鎌足　雄司、田中　義正、藤本　直浩、岡田　卓哉、豊岡　尚樹、五十里　彰、遠藤　智史
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 11-ケト-C19-ステロイドの還元代謝酵素の同定2020
- Author(s)
  工藤　優大、松永　俊之、遠藤　智史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] Nrf2シグナルを標的としたカバジタキセル耐性前立腺癌に対する治療戦略の開発2020
- Author(s)
  河合　弥菜、星　真奈美、瀬川　仁、藤田　芽衣、松川　卓生、藤本　直浩、松永　俊之、五十里　彰、遠藤　智史
- Organizer
  第29回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] 新規オートファジー特異的阻害剤の創製と前立腺癌治療への応用2020
- Author(s)
  藤田　芽衣、工藤　優大、鎌足　雄司、田中　義正、藤本　直浩、岡田　卓哉、豊岡　尚樹、五十里　彰、遠藤　智史
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-20K05751
[Presentation] 去勢抵抗性前立腺がんの新規治療薬アパルタミドの治療効果の最大化を目指した併用薬の開発2020
- Author(s)
  瀬川　仁、星　真奈美、河合　弥菜、藤田　芽衣、豊岡　尚樹、藤本　直浩、松永　俊之、五十里　彰、遠藤　智史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] アンドロゲン合成酵素を標的とした新規去勢抵抗性前立腺がん治療薬の開発2019
- Author(s)
  遠藤　智史、瀬川　仁、小栗　弘成、夏　爽、胡　大イ、入江　克雅、藤井　晋也、合田　浩明、松川　卓生、藤本　直浩、中山　敏幸、豊岡　尚樹、松永　俊之、五十里　彰
- Organizer
  第47回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] アルドケト還元酵素1C3を標的とした去勢抵抗性前立腺癌治療薬の創製研究2019
- Author(s)
  遠藤　智史、河合　弥菜、瀬川　仁、小栗　弘成、藤本　直浩、豊岡　尚樹、松永　俊之、五十里　彰
- Organizer
  第28回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] 新規3(17)β-ヒドロキシステロイド脱水素酵素DHRS11の性状解析とウサギアイソザイムとの相違点2019
- Author(s)
  遠藤　智史、宮城　菜未希、松永　俊之、五十里　彰
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] Development and characterization of novel AKR1C3 inhibitors; therapeutic potential for castration-resistant prostate cancer2019
- Author(s)
  Naohiro Fujimoto, Ikko Tomisaki, Satoshi Endo, Hiroaki Oguri, Naoki Toyooka, Toshiyuki Matsunaga, Akira Ikari and Toshiyuki Nakayama
- Organizer
  20th International EAUN Meeting EAU19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] 前立腺癌細胞のカバジタキセル耐性克服に向けたNrf2シグナル制御の意義2019
- Author(s)
  河合　弥菜、遠藤　智史、星　真奈美、瀬川　仁、藤田　芽衣、松川　卓生、藤本　直浩、松永　俊之、五十里　彰
- Organizer
  第83回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] Rabbit DHRS11: Identity with acetohexaminde reductase, different from human DHRS112018
- Author(s)
  Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari
- Organizer
  19th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] マルチターゲット型去勢抵抗性前立腺癌治療薬の創製研究2018
- Author(s)
  遠藤　智史
- Organizer
  サラマンカ大学・岐阜薬科大学・岐阜大学　三大学連携学術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] 前立腺癌治療薬の開発を指向したアンドロゲン合成酵素阻害剤の創製研究2018
- Author(s)
  遠藤　智史、小栗　弘成、藤本　直浩、豊岡　尚樹、松永　俊之、五十里　彰
- Organizer
  日病薬東海ブロック・薬学会東海支部合同学術大会2018
- Invited
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] マルチターゲット型去勢抵抗性前立腺癌治療薬の創製研究2018
- Author(s)
  遠藤　智史
- Organizer
  サラマンカ大学・岐阜薬科大学・岐阜大学　三大学連携学術シンポジウム　がん研究の最前線　　～がん克服に向けて（対がん）～
- Invited
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] 抗がん剤によるTRPM6マグネシウムチャネルの発現低下に対するロシグリタゾンの回復効果2018
- Author(s)
  眞鍋　綾、古川　千紗、遠藤　智史、松永　俊之、長谷川　元、五十里　彰
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 去勢抵抗性前立腺癌治療薬を指向した新規AKR1C3阻害剤の創製2018
- Author(s)
  遠藤　智史
- Organizer
  第3回名大医薬系3部局交流シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] TNF-alphaによるTRPM6マグネシウムチャネルの発現増加機構の解明2017
- Author(s)
  古川千紗、眞鍋綾、藤井尚子、遠藤智史、松永俊之、山崎泰広、山口賢彦、五十里彰
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] PDZRN3によるクローディン-16マグネシウムチャネルのエンドサイトーシス機構の解明2017
- Author(s)
  丸中　歌菜、古田　巧、長谷川　元、松永　俊之、遠藤　智史、五十里　彰
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2017
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 耐性克服効果を併せ持つ新規抗がん剤開発を指向した選択的AKR1B10阻害剤の創製2017
- Author(s)
  *遠藤　智史
- Organizer
  第6回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜
- Invited
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] 分子動力学計算を用いたアルドケト還元酵素AKR1C3のC154Y及びL159V変異体の溶液構造解析2017
- Author(s)
  渡邉　友里江、早川　大地、遠藤　智史、合田　浩明
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-17K11151
[Presentation] E3-ユビキチンリガーゼによるクローディン-16マグネシウムチャネルの細胞内局在の調節2017
- Author(s)
  丸中　歌菜、古川　千紗、藤井　尚子、木村　徹、遠藤　智史、松永　俊之、山口　賢彦、山崎　泰広、五十里　彰
- Organizer
  第81回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] クローディン-2の異常発現による抗がん剤感受性の変化2017
- Author(s)
  五十里　彰、丸橋　亮平、秋月　梨佐、遠藤　智史、松永　俊之、山崎　泰広、山口　賢彦
- Organizer
  2017年度生命科学系学会合同年次大会ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] プリマキンによるクローディン-16変異体の局在異常の改善2017
- Author(s)
  丸中　歌菜、古田　巧、遠藤　智史、松永　俊之、五十里　彰
- Organizer
  2017年度生命科学系学会合同年次大会ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] PDZRN3によるクローディン-16の細胞内局在の調節2017
- Author(s)
  丸中歌奈、古川千紗、藤井尚子、木村徹、遠藤智史、松永俊之、山崎泰広、山口賢彦、五十里彰
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 肺腺がん細胞のクローディン-2発現を抑制するフラボノイドの探索と機序の解明2016
- Author(s)
  園木寛之、谷前朝海、遠藤智史、松永俊之、五十里彰
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  愛知
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] クラスリン依存性エンドサイトーシスを介した細胞間接着分子claudinの発現調節2016
- Author(s)
  藤井尚子、遠藤智史、松永俊之、五十里彰
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 抗がん剤によるMg2+チャネルの発現低下に対するTNF-aの回復効果2016
- Author(s)
  古川千紗、藤井尚子、遠藤智史、松永俊之、長谷川元、山口賢彦、山崎泰広、菅谷純子、伊藤善規、五十里彰
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 家族性筋萎縮性側索硬化症患者から見出されたアルドケト還元酵素1C3の新規遺伝子変異の性状解析2016
- Author(s)
  遠藤　智史、高田　明香、本田　諒、Kathrin Muller、鎌足　雄司、松永　俊之、桑田　一夫、Jochen Weishaupt、五十里　彰
- Organizer
  第62回　日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] クローディン-18による肺腺がん細胞の増殖抑制におけるZO-2の関与2016
- Author(s)
  秋月梨佐、下馬場駿、松永俊之、遠藤智史、五十里彰
- Organizer
  第63回中部日本生理学会
- Place of Presentation
  愛知
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] Instability of C154Y variant of aldo-keto reductase 1C3 found in familial amyotrophic lateral sclerosis2016
- Author(s)
  Satoshi Endo, Sayaka Takada, Ryo Honda, Kathrin Muller, Yuji O. Kamatari, Toshiyuki Matsunaga, Kazuo Kuwata, Jochen Weishaupt, Akira Ikari
- Organizer
  18th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism
- Place of Presentation
  Costa Brava, Spain
- Year and Date
  2016-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] 肺腺癌細胞におけるクローディン-2発現に対するHDAC阻害剤の効果2016
- Author(s)
  岡本美樹、多賀小枝子、七野亜沙美、松永俊之、遠藤智史、五十里彰
- Organizer
  第80回日本生化学会中部支部シンポジウム
- Place of Presentation
  三重
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 肺腺癌細胞のクローディン-2発現と抗癌剤感受性に対するカフェ酸フェネチルエステルの効果2016
- Author(s)
  谷前朝海、園木寛之、遠藤智史、松永俊之、五十里彰
- Organizer
  第7回機能性健康食品研究講演会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 細胞間接着分子クローディンが起点となる肺扁平上皮癌の細胞増殖調節機構2016
- Author(s)
  秋月梨佐、下馬場駿、松永俊之、遠藤智史、五十里彰
- Organizer
  第62回日本薬学会東海支部大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] アンドロゲン合成酵素を標的とした去勢抵抗性前立腺癌治療薬の創製研究2015
- Author(s)
  遠藤　智史
- Organizer
  第4回岐阜構造生物学・医学・論理的創薬研究会シンポジウム (岐阜) 招待講演
- Place of Presentation
  岐阜
- Year and Date
  2015-03-05
- Invited
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] Aldo-keto reductases as targets for drug development2015
- Author(s)
  遠藤智史
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] 肺腺癌細胞におけるクローディン-2のエンドサイトーシスによるネクローシスの誘導2015
- Author(s)
  五十里彰、多賀小枝子、下馬場俊、遠藤智史、松永俊之、渡邊諒、菅谷純子
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  兵庫
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] クローディン-2指向性ペプチドによるクラスリン依存性エンドサイトーシスを介した細胞障害機構の解明2015
- Author(s)
  多賀小枝子、下馬場俊、遠藤智史、松永俊之、渡邊諒、佐藤友成、菅谷純子、五十里彰
- Organizer
  第78回日本生化学会中部支部例会
- Place of Presentation
  長野
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] 高浸透圧によるクローディン-2発現の低下におけるPKCβの関与2015
- Author(s)
  藤井尚子、遠藤智史、松永俊之、山崎泰広、山口賢彦、菅谷純子、五十里彰
- Organizer
  第78回日本生化学会中部支部例会
- Place of Presentation
  長野
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] PI3K/Akt経路の阻害を介したクローディン-18による肺腺癌細胞の増殖・浸潤抑制2015
- Author(s)
  下馬場俊、多賀小枝子、遠藤智史、松永俊之、渡邊諒、佐藤友成、菅谷純子、五十里彰
- Organizer
  第61回日本薬学会東海支部大会
- Place of Presentation
  愛知
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-15H04657
[Presentation] AKR1B10 を標的とする抗癌剤開発を指向した構造活性相関研究2014
- Author(s)
  陶山　美穂、遠藤　智史、松永　俊之、五十里　彰、胡　大イ、豊岡　尚樹
- Organizer
  78回日本生化学会中部支部例会
- Place of Presentation
  名古屋
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-26460149
[Presentation] ウサギの3-hydroxyhexobarbital dehydrogenaseはketosteroids、prostaglandin D2、その他のカルボニル化合物に広い特異性を示す還元酵素である2013
- Author(s)
  原明、遠藤智史、山野茂、松本淳子、荒井裕貴、松永俊之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] 2-Phenyliminochromene誘導体の癌マーカーAKR1B10阻害活性に関する構造活性相関2013
- Author(s)
  陶山美穂、遠藤智史、松永俊之、胡大イ、杉本健士、松谷裕二、豊岡尚樹、桑田一夫、原明
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  西宮
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] 2-Phenyliminochromene誘導体の癌マーカーAKR1B10阻害活性に関する構造活性相関2013
- Author(s)
  陶山美穂、遠藤智史、松永俊之、胡大イ、杉本健士、松谷裕二、豊岡尚樹、桑田一夫、原明
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  兵庫
- Year and Date
  2013-11-07
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein by oxidized glutathione and SH-reagents2012
- Author(s)
  Satoshi Endo, Sho Kumada, Airi Fujimoto, Toshiyuki Matsunaga, Satoshi Ohno, Jun'ichi Mano, Kazuo Tajima, Ossama El-Kabbani, and Akira Hara
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM SIXTEENTH INTERNATIONAL MEETING
- Place of Presentation
  Plon, GERMANY
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] Ossama El-Kabbani, and Akira Hara、Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein by oxidized glutathione and SH-reagents2012
- Author(s)
  Satoshi Endo, Sho Kumada, Airi Fujimoto, Toshiyuki Matsunaga, Satoshi Ohno, Jun'ichi Mano, Kazuo Tajima
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM SIXTEENTH INTERNATIONAL MEETING
- Place of Presentation
  Plön, GERMANY
- Data Source
  KAKENHI-PROJECT-24790114
[Presentation] 高次構造に基づいた癌マーカーAKR1B10の強力かつ選択的な阻害剤の創製2012
- Author(s)
  遠藤智史
- Organizer
  第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜
- Year and Date
  2012-02-23
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Design, Synthesis and Evaluation of Caffeic Acid Phenethyl Ester-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human Aldo-Keto Reductase (AKE) 1B102011
- Author(s)
  Satoshi Endo, 他11名
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Design, Synthesis and Evaluation of Caffeic Acid Phenethyl Ester-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human Aldo-Keto Reductase(AKR) 1B102011
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Midori Soda, Mayuko Takemura, Dawei Hu, Jie Li, Ryogo Wada, Syohei Ifuku, Naoki Toyooka, Hai-Tao Zhao, Ossama El-Kabbani and Akira
- Organizer
  8th AFMC International Medicinal Chemistry Symposium(AIMECS11)
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol2010
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Chisato Ohta, Midori Soda, Ayano Kanamori, Yukio Kitade, Satoshi Ohno, Kazuo Tajima, Ossama El-Kabbani, Akira Hara
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM FIFTEENTH INTERNATIONAL MEETING
- Place of Presentation
  LEXINGTON, KENTUCKY
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] バーチャルスクリーニングを用いた癌マーカー酵素AKR1B10の強力な阻害剤の探索2010
- Author(s)
  遠藤智史、松永俊之、桑田一夫、Ossama El-Kabbani、北出幸夫、原明
- Organizer
  74回日本生化学会中部支部例会
- Place of Presentation
  名古屋
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] 非ステロイド性抗炎症薬による癌マーカーAKR1B10の阻害2010
- Author(s)
  遠藤智史、松永俊之、曽田翠、田島和男、Ossama El-Kabbani, 原明
- Organizer
  第56回日本薬学会東海支部総会・大会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol.2010
- Author(s)
  Satoshi Endo
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM FIFTEENTH INTERNATIONAL MEETING
- Place of Presentation
  LEXINGTON, KENTUCKY, USA
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] アルドケト還元酵素AKR1C3の脂肪族アルデヒドに対する特異性と選択的阻害剤2010
- Author(s)
  金森綾野、遠藤智史、松永俊之、原明, Ossama El-Kabbani
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] 癌マーカーAKR1B10によるイソプレニルアルデヒド還元代謝2009
- Author(s)
  遠藤智史
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Inhibitory Effects of Drugs and Dietary Plant Components on the Tumor Marker AKR1B102009
- Author(s)
  Satoshi Endo
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] ヒトの新規カルボニル還元酵素遺伝子産物(CBR4)の機能解析2009
- Author(s)
  遠藤智史
- Organizer
  第53回日本薬学会東海支部総会・大会
- Place of Presentation
  愛知
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] 高次構造に基づく20α-ヒドロキシステロイド脱水素酵素阻害剤の合成・評価2009
- Author(s)
  曽田翠、遠藤智史、松永俊之、原明、Ossama El-Kabbani
- Organizer
  73回日本生化学会中部支部例会
- Place of Presentation
  名古屋
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] 癌マーカーAKR1B10によるイソプレニルアルデヒド還元代謝2009
- Author(s)
  遠藤智史、松永俊之、曽田翠、原明、田島和男
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Characterization of a rat aldo-keto reductase (AKR1B13) up-regulated by oxidative stress2008
- Author(s)
  Satoshi Endo
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 14th INTERNATIONAL MEETING
- Place of Presentation
  KRANTSKA GORA, SLOVENIA
- Data Source
  KAKENHI-PROJECT-19890180
[Presentation] Characterization of a rat aldo-keto reductase (AKR1B13) up-regulated by oxidative stress2008
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Hiroaki Mamiya, Akira Hara, Kazuo Tajima, Yukio Kitade, Ossama El-Kabbani
- Organizer
  ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM FOURTEENTH INTERNATIONAL MEETING
- Place of Presentation
  KRANJSKA GORA, SLOVENIA JULY
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19890180
[Presentation] ヒトの誘導性SDR ファミリータンパク質(DHRS4)の性状2008
- Author(s)
  前田哲志、遠藤智史、松永俊之、原明、田中信忠、中村和郎、田島和男
- Organizer
  第72 回日本生化学会中部支部例会
- Place of Presentation
  岐阜
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19890180
[Presentation] Identification of substrate specificity determinants of rodent NAD+-dependent 3α/17β/20α-hydroxysteroid dehydrogenases by site-directed mutagenesis2007
- Author(s)
  遠藤智史
- Organizer
  第80回日本生化学会大会第30回日本分子生物学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19890180
[Presentation] Identification of substrate specificity determinants of rodent NAD+-dependent 3a/17b/20a-hydroxysteroid dehydrogenases by site-directed mutagenesis2007
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Kazuo Tajima, and Akira Hara
- Organizer
  第80 回日本生化学会大会第30 回日本分子生物学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19890180
[Presentation] ヒトの新規カルボニル還元酵素遺伝子産物(CBR4)の機能解析
- Author(s)
  遠藤智史, 松永俊之, 北出幸夫, 田島和男, Ossama El-Kabbani, 原明
- Data Source
  KAKENHI-PROJECT-21790245
[Presentation] Aldo-keto reductase1C3(AKR1C3) 選択的阻害活性を有する baccharin非プレニル誘導体の合成
- Author(s)
  遠藤　智史、胡　大イ、松永　俊之、大辻　陽子、Ossama EI-Kabbani、Mahmoud Kandeel、五十里　彰、原　明、北出　幸夫、豊岡　尚樹
- Organizer
  第32回メディシナルシンポジウム（神戸）
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26460149

1. TOYOOKA Naoki (10217565)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. HARA Akira (00094334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. GODA Hiroaki (60276160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. TANAKA Nobutada (00286866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUWATA Kazuo (00170142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. IKARI AKIRA (50315850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
7. 古田巧 (30336656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. KATO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUNAGA Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. EL-KABBANI Ossama

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. ISHIKAWA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. HONDA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 酒井秀紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Endo Satoshi 遠藤 智史

ENDO Satoshi 遠藤 智史

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アミロイド線維の戦略的蓄積による画期的がん治療戦略の確立Principal Investigator

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Research and development of autophagy-specific inhibitors

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Reconsidering the significance of autophagy in urological cancer and drug discoveryPrincipal Investigator

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Development of a multi-targeted castration-resistant prostate cancer drug for clinical applicationPrincipal Investigator

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Establishment of the basis for evolutional drug development toward avoidance of hypomagnesemia

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Development of novel anticancer agents targeting survival strategy of cancer cellsPrincipal Investigator

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Development of novel anticancer drugs targeting for controlling the function and expression of oxidative stress-induced proteinPrincipal Investigator

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DEVELOPMENT OF ANTITUMOR DRUGS TARGETING TUMOR MARKERALDO-KETO REDUCTASES

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Development of antitumor agents targeting for prenoid-metabolizing enzymesPrincipal Investigator

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Elucidation of defense mechanism against carbonyl stress by reductases for carbonyl compoundsPrincipal Investigator

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[Journal Article] Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells2023

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[Journal Article] Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer2022

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[Journal Article] Correction to “Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer”2022

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Endo Satoshi 遠藤智史

ENDO Satoshi 遠藤智史