Osawa Yosuke 大澤陽介

… Alternative Names

大澤陽介オオサワヨウスケ

OSAWA Yosuke 大澤陽介

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Researcher Number	60447787
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 国際医療福祉大学, 医学部, 教授 2017: 国立研究開発法人国立国際医療研究センター, その他部局等, 第三肝疾患室医長 2016: 東京都立駒込病院(臨床研究室), 肝臓内科, 医長 2015: 東京都立駒込病院, 肝臓内科, 医長 2015: 岐阜大学, 大学院医学系研究科, 講師 … More 2014 – 2015: 東京都立駒込病院(臨床研究室), その他部局等, その他 2014: 東京都立駒込病院(臨床研究室), 肝臓内科, 非常勤医師 2011 – 2013: 岐阜大学, 医学(系)研究科(研究院), 講師 2010 – 2012: Gifu University, 医学系研究科, 助教 2008 – 2012: Gifu University, 大学院・医学系研究科, 助教 2011: 岐阜大学, 医学系研究科, 講師 2008: Gifu University, 大学院医学系研究科, 助教授 2007: Gifu University, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Dermatology / Biological pharmacy / Laboratory medicine
Keywords	Principal Investigator 肝線維化 / スフィンゴ脂質 / 転移性肝腫瘍 / 脂肪肝 / 肝再生 / クッパー細胞 / アポトーシス / 慢性肝障害 / うっ血性肝障害 / 腸内細菌 … More / ERK / 血管新生 / 肝細胞がん / 肝発がん / スフィンゴシン１リン酸 / 肝血管新生 / うっ血肝 / マクロファージ / 酸性スフィンゴミエリナーゼ / Wnt/βカテニンシグナル / スフィンゴ脂質シグナル / 原発性肝腫瘍 / βカテニンシグナル / mTOR / オートファジー / セロトニン / トリプトファン / 脂肪肝炎 / 脂質代謝 / 糖代謝 / 肝細胞 / スフィンゴミエリナーゼ … More Except Principal Investigator アポトーシス / HCV / wnt シグナル / MMP / PRI-724 / Wnt阻害剤 / 肝硬変 / 線維化 / interferon gamma / 乾癬 / インターフェロンγ / アトピー性皮膚炎 / バリア機能 / 長鎖脂肪酸セラミド / 角層脂質 / IFN-γ / インターフェロン-γ / サイトカイン / セラミド / 角層バリア機構 / PI3キナーゼ / 細胞増殖 / Ｂａｘ / ＨＳＰ20 / JNK / 転移 / 浸潤 / リン酸化 / 肝細胞癌 / Bax / ホスファチジルイノシトール3-キナーゼ / HSP20 / 低分子量 / ストレス蛋白質 / 増殖 / 肝細胞がん / 幹細胞 / がん幹細胞 / 大腸癌 / 抗癌剤耐性 / スフィンゴ脂質 / CPTII遺伝子 / FACS / フローサイトメトリー / 遺伝子解析 / リアノジン受容体 / 細胞内カルシウム / 筋障害 / スタチン製剤 / 転写因子 / 肝炎 / 遺伝子治療 / 再生医療 / 肝不全 Less

うっ血による肝細胞がんおよび転移性肝がん増殖機構の解明Principal Investigator
- Principal Investigator
  
  大澤陽介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  International University of Health and Welfare
Development of new anti-fibrotic therapeutic drug for targeting Wnt signal
- Principal Investigator
  
  Kimura Kiminori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Komagome Hospital (Clinical research laboratory)
Acid sphingomyelinase-derived liver macrophage inhibits growth of metastatic colon cancer in the liver.Principal Investigator
- Principal Investigator
  
  Yosuke Osawa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Komagome Hospital (Clinical research laboratory)
New barrier function of stratum corneum and its regulation in inflammatory skin diseases
- Principal Investigator
  
  Kanoh Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Gifu University
Molecular targets of low-molecular-weight heat shock proteins in hepatocellular carcinoma cell proliferation
- Principal Investigator
  
  KOZAWA Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Role of L-Tryptophan on NAFLD and NASHPrincipal Investigator
- Principal Investigator
  
  OSAWA Yosuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Screening and gene analysis for the protection from muscle damage by statin drugs
- Principal Investigator
  
  SEISHIMA Mitsuru
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gifu University
Control mechanism of anti-cancer drug resistance by sphingolipid
- Principal Investigator
  
  BANNO Yoshiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
Role of Kupffer cells on chronic liver injuryPrincipal Investigator
- Principal Investigator
  
  OSAWA Yosuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Development of regenerative medicine and therapeutic system for hepatic failure applied by hepatocyte nuclear factor 4
- Principal Investigator
  
  NAGAKI Masahito
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Role of sphingolipids on hepatocyte apoptosis of chronic liver injuryPrincipal Investigator
- Principal Investigator
  
  OSAWA Yosuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University

[Book] 2nd edition of Essentials of Apoptosis. Part III Apoptosis in mammalian physiology and pathogenesis. Chapter 24 Apoptosis in liver injury and liver diseases.2009
- Author(s)
  Osawa, Y., Seki, E., Brenner DA.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells <i>in vitro</i>2023
- Author(s)
  Mori Taizo、Yoshio Sachiyo、Yoshikawa Shiori、Tsustui Yuriko、Sakata Toshihiro、Yoshida Yuichi、Sakamoto Yuzuru、Kawai Hironari、Osawa Yosuke、Yamazoe Taiji、Aoki Yoshihiko、Fletcher Simon P.、Kanto Tatsuya
- Journal Title
  
  Liver International
  
  Volume: 43 Issue: 6 Pages: 1213-1224
- DOI
  10.1111/liv.15568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15507, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038
[Journal Article] Cases of Rapid Hepatitis B Surface Antigen Reduction after COVID-19 Vaccination2023
- Author(s)
  Osawa Yosuke、Ohtake Takaaki、Suto Daisuke、Akita Takayuki、Yamada Hidehiko、Kohgo Yutaka、Murata Kazumoto
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 1 Pages: 51-57
- DOI
  10.2169/internalmedicine.0842-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-22K07991
[Journal Article] Exercise changes the intrahepatic immune cell profile and inhibits the progression of nonalcoholic steatohepatitis in a mouse model2023
- Author(s)
  Tsutsui Yuriko、Mori Taizo、Yoshio Sachiyo、Sato Miku、Sakata Toshihiro、Yoshida Yuichi、Kawai Hironari、Yoshikawa Shiori、Yamazoe Taiji、Matsuda Michitaka、Kakazu Eiji、Osawa Yosuke、Oyama Chinatsu、Tamura-Nakano Miwa、Kawaguchi Takumi、Yoshizumi Tomoharu、Kanto Tatsuya
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 10
- DOI
  10.1097/hc9.0000000000000236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038
[Journal Article] Anti-acid treatment for ulcerated early gastric cancer may be a treatment option avoiding unnecessary gastrectomy: a cohort study2023
- Author(s)
  Suto Daisuke、Yoshida Masashi、Otake Takaaki、Osawa Yosuke、Sato Kiichi、Yamada Hidehiko、Akita Takayuki、Ohdaira Hironori、Suzuki Yutaka、Kohgo Yutaka
- Journal Title
  
  Annals of Medicine & Surgery
  
  Volume: 85 Issue: 7 Pages: 3269-3272
- DOI
  10.1097/ms9.0000000000000874
- Data Source
  KAKENHI-PROJECT-21K08014
[Journal Article] Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder2023
- Author(s)
  Yamaji Kenzaburo、Iwabuchi Sadahiro、Tokunaga Yuko、Hashimoto Shinichi、Yamane Daisuke、Toyama Sakiko、Kono Risa、Kitab Bouchra、Tsukiyama-Kohara Kyoko、Osawa Yosuke、Hayashi Yukiko、Hishima Tsunekazu、Tateno Chise、Kimura Kiminori、Okanoue Takeshi、Kohara Michinori
- Journal Title
  
  Biomedicine Pharmacotherapy
  
  Volume: 166 Pages: 115379-115379
- DOI
  10.1016/j.biopha.2023.115379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06981, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-23K21382
[Journal Article] Non-traumatic False Cyst of the Spleen: A Case Report and Review of the Literature2023
- Author(s)
  Osawa Yosuke、Nakaseko Yuichi、Nakashima Keigo、Suto Daisuke、Odaira Hironori、Kohgo Yutaka、Suzuki Yutaka、Ohtake Takaaki
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 7 Pages: 1005-1009
- DOI
  10.2169/internalmedicine.0284-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-04-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-21K08014
[Journal Article] Peripheral‐dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy2022
- Author(s)
  Kawai Hironari、Osawa Yosuke、et al.
- Journal Title
  
  Hepatology Research
  
  Volume: 53 Issue: 4 Pages: 370-376
- DOI
  10.1111/hepr.13866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-23K27671
[Journal Article] Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients2021
- Author(s)
  Osawa Yosuke、Yoshio Sachiyo、Aoki Yoshihiko、Korenaga Masaaki、Imamura Masatoshi、Oide Takashi、Okawara Miku、Kawai Hironari、Tsutsui Yuriko、Yoshida Yuichi、Yoshikawa Shiori、Mori Taizo、Yamazoe Taiji、Kanto Tatsuya
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1 Pages: 000-000
- DOI
  10.1186/s12876-021-01633-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K08014
[Journal Article] Increased Frequency of Dysfunctional Siglec-7?CD57+PD-1+ Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease2021
- Author(s)
  Sakamoto Yuzuru, Yoshio Sachiyo, et al
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 603133-603133
- DOI
  10.3389/fimmu.2021.603133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17509, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K08020
[Journal Article] Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy2021
- Author(s)
  Kawai H, Osawa Y, Matsuda M, Tsunoda T, Yanagida K, Hishikawa D, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, Yoshida Y, Yoshikawa S, Hashi K, Doi H, Mori T, Yamazoe T, Yoshio S, Sugiyama M, Okuzaki D, Komatsu H, Inui A, Tamura-Nakano M, Oyama C, Shindou H, Kusano H, Kage M, Ikegami T, Yanaga K, Kanto T
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 1 Pages: 112-125
- DOI
  10.1002/hep.32256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08900, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Myostatin as a fibroblast‐activating factor impacts on postoperative outcome in patients with hepatocellular carcinoma2021
- Author(s)
  Yoshio Sachiyo、Shimagaki Tomonari、Hashida Ryuki、Kawaguchi Takumi、Tsutsui Yuriko、Sakamoto Yuzuru、Yoshida Yuichi、Kawai Hironari、Yoshikawa Shiori、Yamazoe Taiji、Mori Taizo、Osawa Yosuke、Itoh Shinji、Fukai Moto、Yoshizumi Tomoharu、Taketomi Akinobu、Mori Masaki、Kanto Tatsuya
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Issue: 7 Pages: 803-812
- DOI
  10.1111/hepr.13667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Cluster of Differentiation 44 Promotes Liver Fibrosis and Serves as a Biomarker in Congestive Hepatopathy2021
- Author(s)
  Osawa Y, Kawai H, Yamazoe T, Kanto T, et al.
- Journal Title
  
  Hepatology Communications
  
  Volume: 5 Issue: 8 Pages: 1437-1447
- DOI
  10.1002/hep4.1721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Tumor Necrosis Factor-a-Mediated Hepatocyte Apoptosis Stimulates Fibrosis in the Steatotic Liver in Mice2018
- Author(s)
  Yosuke Osawa,1,2 Ekumi Kojika,1 Yukiko Hayashi,1 Masamichi Kimura,1 Koji Nishikawa,1 Sachiyo Yoshio,2 Hiroyoshi Doi,2 Tatsuya Kanto,2 and Kiminori Kimura1
- Journal Title
  
  HEPATOLOGY COMMUNICATIONS
  
  Volume: 2 Issue: 4 Pages: 407-420
- DOI
  10.1002/hep4.1158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09037, KAKENHI-PROJECT-18K08021, KAKENHI-PROJECT-18K15768
[Journal Article] Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial.2017
- Author(s)
  2.Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M.
- Journal Title
  
  EBioMedicine
  
  Volume: 23 Pages: 79-87
- DOI
  10.1016/j.ebiom.2017.08.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09037, KAKENHI-PROJECT-15K15146
[Journal Article] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model2017
- Author(s)
  Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, and *Michinori Kohara
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 325-325
- DOI
  10.1038/s41598-017-00282-w
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-26460965, KAKENHI-PROJECT-26860312, KAKENHI-PROJECT-16K18467, KAKENHI-PROJECT-17K15584, KAKENHI-PROJECT-15K15146
[Journal Article] Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)- binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.2015
- Author(s)
  Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K
- Journal Title
  
  EBioMedicine
  
  Volume: 2 Issue: 11 Pages: 1751-8
- DOI
  10.1016/j.ebiom.2015.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-15K09037, KAKENHI-PROJECT-26460965
[Journal Article] Blockade of Indoleamine 2,3-Dioxygenase Reduces Mortality from Peritonitis and Sepsis in Mice by Regulating Functions of CD11b+ Peritoneal Cells.2014
- Author(s)
  Hoshi M, Osawa Y ら
- Journal Title
  
  Infect Immun
  
  Volume: 82 Pages: 4487-4495
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460965
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer．2013
- Author(s)
  Osawa Y,Saibara T et.al
- Journal Title
  
  Journal Clin Invest
  
  Volume: 123(2) Pages: 834-843
- DOI
  10.1172/jci65188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-221S0001
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer2013
- Author(s)
  Osawa Y
- Journal Title
  
  J Clin Invest
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390179
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer2013
- Author(s)
  Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O.
- Journal Title
  
  J Clin Invest
  
  Volume: 123 Pages: 834-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.2012
- Author(s)
  Ohtaki H, Ito H, Hoshi M, Osawa Y,Takamatsu M, Hara A, Ishikawa T,Moriwaki H, Saito K, Seishima M.
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 367-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] L-Tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice.2012
- Author(s)
  Hoshi M, Matsumoto K, Ito H, Ohtaki H, Arioka Y, Osawa Y, Yamamoto Y, Matsunami H, Hara A, Seishima M, Saito K.
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 3980-3987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2.2012
- Author(s)
  Mizutani N, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Nishida Y , Takagi A, Kojima T, Suzuki M, Osawa Y, Ohnishi K, Daibata M, Murate T.
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 74 Pages: 261-271
- NAID
  120004608905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] The cyan fluorescent protein nude mouse2012
- Author(s)
  Suetsugu A, Osawa Y,ら
- Journal Title
  
  Anticancer Res.
  
  Volume: 32 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments2012
- Author(s)
  Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM.
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression2011
- Author(s)
  Osawa, Y., Seki, Y., Kodama, A., Suetsugu, K., Miura, M., Adachi, H., Ito, Y., Shiratori, Y., Banno, Y., Olefsky, J. M., Nagaki, M., Moriwaki, H., Brenner, D. A., Seishima, M.
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590061
[Journal Article] Imaging the recruitment of cancer-associated2011
- Author(s)
  Suetsugu A, Osawa Y,ら
- Journal Title
  
  J Cell Biochem.
  
  Volume: 112 Issue: 3 Pages: 949-953
- DOI
  10.1002/jcb.23011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S,Moriwaki H, Bouvet M, Hoffman, RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 112 Pages: 949-953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] L-Tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.2011
- Author(s)
  Osawa Y, Kanamori H, Seki E, Hoshi M,Ohtaki H, Yasuda Y, Ito H, Suetsugu A,Nagaki M, Moriwaki H, Saito K, Seishima M.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 34800-34808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shirator,i Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, ら
- Journal Title
  
  FASEB J.
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
- Journal Title
  
  FASEB J
  
  Volume: 25 Issue: 4 Pages: 1133-44
- DOI
  10.1096/fj.10-168351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-22590728
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 112 Pages: 949-953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A Miura K, Adachi M, Ito H, Shiratori Y, Banno I, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] L-tryptophan-mediated enhancement2011
- Author(s)
  Osawa Y,　ら
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Pages: 34800-34808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, ら
- Journal Title
  
  J Cell Biochem.
  
  Volume: 112 Pages: 949-953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin2011
- Author(s)
  Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 40 Pages: 34800-34808
- DOI
  10.1074/jbc.m111.235473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06850, KAKENHI-PROJECT-20390167, KAKENHI-PROJECT-21390179
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J 25
  
  Pages: 1133-1144
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression2011
- Author(s)
  Osawa, Y., et.al.
- Journal Title
  
  FASEB J.
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590061
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu, A., Osawa, Y., Nagaki, M., Saji, S., Moriwaki, H., Bouvet, M., Hoffman, R.M.
- Journal Title
  
  J Cell Biochem. 112
  
  Pages: 949-953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Acid sphingomyelinase regulates glucose and lipid2011
- Author(s)
  Osawa Y ら
- Journal Title
  
  FASEB J.
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790787
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa, Y., et al.
- Journal Title
  
  FASEB J.
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590061
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem 112
  
  Pages: 949-953
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.2010
- Author(s)
  Hoshi, M., Saito, K., Hara, A., Taguchi, A., Ohtaki, H., Tanaka, R., Fujigaki, H., Osawa, Y., Takemura, M., Matsunami, H., Ito, H., Seishima, M.
- Journal Title
  
  J Immunol. 185
  
  Pages: 3305-3312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M.
- Journal Title
  
  Hepatology 51
  
  Pages: 237-245
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, ら
- Journal Title
  
  Hepatology 51
  
  Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 111 Pages: 1035-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu A, Osawa Y, ら
- Journal Title
  
  J Cell Biochem.
  
  Volume: 111 Pages: 1035-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu, A., Osawa, Y., Nagaki, M., Moriwaki, H., Saji, S., Bouvet, M., Hoffman, R.M.
- Journal Title
  
  J Cell Biochem. 111
  
  Pages: 1035-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa, Y., Seki, E., Adachi, M., Suetsugu, A., Ito, H., Moriwaki, H., Seishima, M., Nagaki, M.
- Journal Title
  
  Hepatology. 51
  
  Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM
- Journal Title
  
  J Cell Biochem 111
  
  Pages: 1035-1041
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.2010
- Author(s)
  Ito, H., Hoshi, M., Ohtaki, H., Taguchi, A., Ando, K., Ishikawa, T., Osawa, Y., Hara, A., Moriwaki, H., Saito, K., Seishima, M.
- Journal Title
  
  J Immunol. 185
  
  Pages: 4554-4550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Role or acid sphingomyelinase of Kuptter cells in cholestaticiver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M.
- Journal Title
  
  Hepatology
  
  Volume: 51 Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylcer amide-induced hepatitis model.2010
- Author(s)
  Ito H, Osawa Y, ら
- Journal Title
  
  J Immunol.
  
  Volume: 185 Pages: 4554-4550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.2010
- Author(s)
  Hoshi M, Osawa Y, ら
- Journal Title
  
  J Immunol.
  
  Volume: 185 Pages: 3305-3312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2009
- Author(s)
  Tsukada, Y., Nagaki, M., Suetsugu, A., Osawa, Y., Moriwaki, H.
- Journal Title
  
  Biochem Biophys Res Commun 381
  
  Pages: 733-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2009
- Author(s)
  Tsukada Y, Osawa Y, ら
- Journal Title
  
  Biochem Biophys Res Commun. 381
  
  Pages: 733-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells.2009
- Author(s)
  Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Hoshi, M., Tanaka, R., Osawa, Y., Yokochi, T., Moriwaki, H., Saito, K., Seishima, M.
- Journal Title
  
  Biochem Biophys Res Commun. 389
  
  Pages: 229-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and AKT activtion.2009
- Author(s)
  Nemoto, S., Nakamura, M., Osawa, Y., Kono, S., Itoh, Y., Okano, Y., Murate, T., Hara, A., Ueda, H., Nozawa, Y., Banno, Y.
- Journal Title
  
  J Biol Chem (in print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation2009
- Author(s)
  Nemoto, S., Nakamura, M., Osawa, Y., Kono, K., Itoh, Y., Okano, Y., Murate, T., Hara, A., Ueda, H., Nozawa, Y., Banno, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 10422-10432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590061
[Journal Article] Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocvte apoptosis.2009
- Author(s)
  Kodama Y, Osawa Y, ら
- Journal Title
  
  Gastroenterology. 136
  
  Pages: 1423-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2009
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Common 381
  
  Pages: 733-737
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.2009
- Author(s)
  Yasuda Y, Osawa Y, ら
- Journal Title
  
  Chem Biol Interact. 182
  
  Pages: 159-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.2009
- Author(s)
  Yasuda, Y., Shimizu, M., Sakai, H., Iwasa, J., Kubota, M., Adachi, S., Osawa, Y., Tsurumi, H., Hara, Y., Moriwaki, H.
- Journal Title
  
  Chem Biol Interact. 182
  
  Pages: 159-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.2009
- Author(s)
  Nemoto S, Osawa Y, ら
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 10422-10432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and AKT activtion2009
- Author(s)
  Nemoto, S., Nakamura, M., Osawa, Y., Kono, S., Itoh, Y., Okano, Y., Murate, T., Hara, A., Ueda, H., Nozawa, Y. , Banno, Y.
- Journal Title
  
  J Biol Chem (in print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis2009
- Author(s)
  Kodama, Y., Taura, K., Miura, K., Schnabl, B., Osawa, Y. and Brenner, D. A.
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1423-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic rogenitor cells.2009
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Commun 381
  
  Pages: 733-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.2009
- Author(s)
  Kodama, Y., Taura, K., Miura, K., Schnabl, B., Osawa, Y., Brenner, D.A.
- Journal Title
  
  Gastroenterology 136
  
  Pages: 1423-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valphal4 NKT cells.2009
- Author(s)
  Ohtaki H, Osawa Y, ら
- Journal Title
  
  Biochem Biophys Res Commun. 389
  
  Pages: 229-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis.2008
- Author(s)
  Osawa Y, Nagaki M.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 772-774
- NAID
  10021945849
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Cyclooxygenase-2: its paradoxical roles in liver inflammation and fibrosis2008
- Author(s)
  Osawa, Y. and Nagaki, M.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 772-774
- NAID
  10021945849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis.2008
- Author(s)
  Osawa Y, Nagaki M.
- Journal Title
  
  Hepatol Res 48
  
  Pages: 772-774
- NAID
  10021945849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis2008
- Author(s)
  Osawa Y, Nagaki M
- Journal Title
  
  Hepatology Research 38
  
  Pages: 123-125
- NAID
  10021945849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB2007
- Author(s)
  Miura, K., Yoshino, R., Hirai, Y., Goto, T., Ohshima, S., Mikami, K., Yoneyama, K., Watanabe, D., Sato, M., Senoo, H., Kodama, Y., Osawa, Y., Brenner, D. A., Watanabe, S.
- Journal Title
  
  J Hepatol 47
  
  Pages: 834-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Alpha-1 antitrypsin Z protein (PiZ)increases hepatic fibrosis in a mu rine model of cholestasis2007
- Author(s)
  Mencin A, Osawa Y
- Journal Title
  
  Hepatology 46
  
  Pages: 1443-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis2007
- Author(s)
  Mencin, A., Seki, E., Osawa, Y., Kodama, Y., De Minicis, S., Knowles, M. and Brenner, D. A.
- Journal Title
  
  Hepatology 46
  
  Pages: 1443-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells2007
- Author(s)
  Adachi, M., Osawa, Y., Uchinami, H., Kitamura, T., Accili, D. and Brenner, D. A.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 1434-1446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells2007
- Author(s)
  Adachi M, Osawa Y
- Journal Title
  
  Gastroenterology 132
  
  Pages: 1434-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] TLR4 enhances TGF-beta signaling and hepatic fibrosis2007
- Author(s)
  Seki, E., De Minicis, S., Osterreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., Schwabe, R. F.
- Journal Title
  
  Nat Med 13
  
  Pages: 1324-1332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790478
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
- Author(s)
  Osawa, Y., Seki, E., Kodama, Y., Suetsugu, A., Miura.K., Adachi, M., Ito, H., Shirator,i Y., Banno, Y., Olefsky, J.M., Nagaki, M., Moriwaki, H., Brenner, D.A., Seishima, M.
- Journal Title
  
  FASEB J. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] FALDの病態解明を目指した発がん機序と局在解析―うっ血肝モデルマウスを用いてー2022
- Author(s)
  河合裕成　大澤陽介　考藤達哉
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] 新型コロナワクチンによるHBs抗原低下効果の検討2022
- Author(s)
  大澤陽介大竹孝明村田一素
- Organizer
  第44回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] Angiopoietin-2はC型慢性肝炎において血管新生と肝線維化を反映する2022
- Author(s)
  大澤陽介由雄祥代考藤達哉
- Organizer
  第26回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] うっ血肝は末梢優位は線維化・腫瘍形成を誘導する2021
- Author(s)
  河合裕成、大澤陽介、考藤達哉
- Organizer
  第57回日本肝臓学会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] うっ血性肝線維化におけるCD44の役割2021
- Author(s)
  大澤陽介、河合裕成、考藤達哉
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] うっ血性肝線維化におけるCD44の役割2021
- Author(s)
  大澤陽介、河合裕成、考藤達哉
- Organizer
  第57回日本肝臓学会
- Data Source
  KAKENHI-PROJECT-21K08014
[Presentation] マウス肝線維化におけるWnt/β-cateninシグナルの関与2016
- Author(s)
  大澤陽介　今村潤　木村公則
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] Inhibition of CBP/β-catenin reduces liver fibrosis in mice.2016
- Author(s)
  Osawa Y, Imamura J, Kimura K
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL)
- Place of Presentation
  Tokyo.
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] マウス肝線維化におけるWnt/β-cateninシグナルの関与2016
- Author(s)
  大澤陽介　今村潤　木村公則
- Organizer
  第１２０回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] マウス肝線維化におけるWnt/β-cateninシグナルの関与2015
- Author(s)
  大澤陽介　今村潤　木村公則
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおけるKupffer細胞とTNF-alphaの役割2014
- Author(s)
  大澤陽介
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] 大腸癌細胞由来転移性肝腫瘍の増殖における酸性スフィンゴミエリナーゼの役割2014
- Author(s)
  大澤陽介
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-23
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおけるKupffer細胞とTNF-αの役割2014
- Author(s)
  大澤陽介
- Organizer
  第28回肝類洞壁細胞研究会学術集会
- Place of Presentation
  岡山
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-26460965
[Presentation] Kupffer cells and fibrosis in2012
- Author(s)
  Osawa Y
- Organizer
  APASL　2012(招待講演)
- Place of Presentation
  台湾
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] ワークショップ 8「NASH/NAFLD から進展する肝硬変・肝癌の現状と対応」非アルコール性肝脂肪化におけるトリプトファンの影響2012
- Author(s)
  大澤陽介森脇久隆清島満
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] L-Tryptophan-mediated enhancement of susceptibility to NAFLD in dependent on the mTOR.2012
- Author(s)
  Osawa Y, Yasuda Y, Suetsugu A, Moriwaki H, Kozawa O
- Organizer
  Asian Pacific Digestive Week (APDW2012).
- Place of Presentation
  Bangkok Thailand
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] Symposium"Liver Fibrosis, Mechanism and Non-invasive Diagnosis" Kupffer cells and fibrosis in cholestatic liver injury in mice.2012
- Author(s)
  Osawa Y
- Organizer
  Asian Pacific Association for the Study of the Liver (AP ASL) 2012
- Place of Presentation
  Taipei. Taiwan
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] ワークショップ「病態栄養からみた肝・胆・膵疾患-治療への応用-」非アルコール性肝脂肪化におけるトリプトファンの影響.2012
- Author(s)
  大澤陽介森脇久隆
- Organizer
  第16回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] Is the measurement of Ca2+-release inCD19+ B cells stimulated by statin useful for prediction of muscle damage as a side effect?2012
- Author(s)
  Mori I, Hattori T, Osawa Y, Kanamori H, Kajita K, Morita H, Ishizuka T, Saito K, Ito H, Seishima M
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] A lipophilic statin, pitavastatin, suppresses azoxymethane-induced and obesity-related colonic premalignant lesions in male db/db mice.2011
- Author(s)
  Yasuda Y, Shimizu M, Sakai H, Kubota M, Osawa Y, Moriwaki H
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2011.
- Place of Presentation
  Bangkok.Thailand
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] A lipophilic statin, pitavastatin, suppresses azoxymethane-induced and obesity-related colonic premalignant lesions in male db/db mice.2011
- Author(s)
  Yasuda Y, Osawa Y, ら
- Organizer
  Asian Pacific Association for the Study of the Liver 2011
- Place of Presentation
  タイバンコク
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Roles of acid sphingomyelinase on glucose and lipid metabolism in hepatocytes.2011
- Author(s)
  Osawa Y, ら
- Organizer
  Asian Pacific Association for the Study of the Liver 2011
- Place of Presentation
  タイバンコク
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes.2011
- Author(s)
  Osawa Y, Suetsugu A, Nagaki M, Moriwaki H, Seishima M
- Organizer
  Digestive Disease Week (DDW) 2011
- Place of Presentation
  Chicago USA
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] 肝臓の糖・脂質代謝における酸性スフィンゴミエリナーゼの役割2011
- Author(s)
  大澤陽介ら
- Organizer
  JDDW2011 (第15回日本肝臓学会大会)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] 肝糖・脂質代謝における酸性スフィンゴミエリナーゼの役割2011
- Author(s)
  大澤陽介末次淳永木正仁森脇久隆清島満
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] Roles of acid sphingomyelinase on glucose and lipid metabolism in hepatocytes.2011
- Author(s)
  Osawa Y, Nagaki M, Yasuda Y, Moriwaki H, Seishima M
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2011.
- Place of Presentation
  Bangkok.Thailand
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Roles of acid sphingomyelinase on glucose and lipid metabolism in hepatocytes.2011
- Author(s)
  Osawa Y, Nagaki M, Yasuda Y, Moriwaki H, Seishima M
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2011
- Place of Presentation
  Bangkok. Thailand
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] シンポジウム「代謝性・遺伝性肝疾患研究の進歩」肝臓の糖・脂質代謝における酸性スフィンゴミエリナーゼの役割2011
- Author(s)
  大澤陽介森脇久隆清島満
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] Acid sphingomielinase regulates glucose and lipid metabolism in hepatocytes2011
- Author(s)
  Osawa Y, et al, 4名
- Organizer
  DDW
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] Acid sphingomyelinase regulates glucose2011
- Author(s)
  Osawa Yら
- Organizer
  Digestive Disease Week (DDW) 2011
- Place of Presentation
  シカゴ
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] 高脂血症治療剤による培養細胞に対するCa^<2+>放出効果の基礎的検討2010
- Author(s)
  服部高幸、竹村正男、太田浩敏、大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島満
- Organizer
  第49回日本臨床検査医学会東海・北陸支部総会第320回日本臨床化学会東海北陸支部例会連合大会
- Place of Presentation
  名古屋市
- Year and Date
  2010-03-14
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose into lerance and insulin resistance.2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
- Organizer
  Digestive Disease Week (DDW) 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Free Paper Session「Basic aspects of inflammation and fibrosis in the liver and pancreas」Toll-like receptors induce lethal hepatic inflammation in D-galactosaminesensitized mice.2010
- Author(s)
  塚田良彦, 永木正仁, 末次淳, 大澤陽介, 木村公則, 森脇久隆
- Organizer
  The 18th United European Gastroenterology Week(UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] パネルディスカッション「肝臓の再生機構を考える:今後の肝再生医療への展望」肝細胞死と肝再生・肝線維化連携機構におけるKupffer細胞の役割2010
- Author(s)
  大澤陽介, 永木正仁, 森脇久隆
- Organizer
  第14回日本肝臓学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] ハルァィスッソヨン「肝臓の再生機構を考える:今後の肝再生医療への展望」肝細胞死と肝再生・肝線維化連携機構におけるKupffer細胞め役割2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2010(第14回日本肝臓学会大会)
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Basic Science Workshop 「Pattern recognition receptor signalling」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Kimura K, Moriwaki H.
- Organizer
  The 18th United European Gastroenterology Week (UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] C型代償性肝硬変におけるIFN-RBV併用療法の治療効果と予後の検討2010
- Author(s)
  内木隆文、永木正仁、清水雅仁、高井光治、白木亮、今井健二、岩砂淳平、大西紘太郎、大澤陽介、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Color-coded imaging of tumor growth, metastasis and drug resistance of co-implanted cancer stem cells and non-cancer stem cells.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Bouvet M, Hoffman RM
- Organizer
  American association of cancer research 101^<st> annual meeting 2010.
- Place of Presentation
  Washington DC USA
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance.2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M
- Organizer
  Digestive Disease Week (DDW) 2010.
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 肝障害誘導におけるToll-like receptorの関与2010
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、木村公則、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおけるKupffer細胞の役割2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  第21回The meeting of liver and Immunology
- Place of Presentation
  東京
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance.2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFR and IGF-1R.2010
- Author(s)
  Yasuda Y, Shimizu M, Sakai H, Kubota M, Osawa Y, Hara Y, Moriwaki H
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010.
- Place of Presentation
  Beijing.China
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance2010
- Author(s)
  Osawa Y, Ito H, Suetusgu A, Nagaki M, Moriwaki H, Seishima M
- Organizer
  DDW 2010
- Place of Presentation
  New Orlealls
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFR and IGF-1R.2010
- Author(s)
  Yasuda Y, Osawa Y, ら
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010
- Place of Presentation
  中国北京
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Role of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, Nagaki M, Yasuda Y, Tsukada Y, Moriwaki H, Seishima M
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010.
- Place of Presentation
  Beijin.China
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Basic Science Workshop「Pattern recognition receptor signalling」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  塚田良彦, 永木正仁, 末次淳, 大澤陽介, 木村公則, 森脇久隆
- Organizer
  The 18th United European Gastroenterology Week(UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] パネルディスカッション「肝臓の再生機構を考える:今後の肝再生医療への展望」肝細胞死と肝再生・肝線維化連携機構におけるKupffer細胞の役割.2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2010(第14回日本肝臓学会大会)
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 高脂血症治療剤による培養細胞に対するCa2+放出効果の基礎的検討2010
- Author(s)
  服部高幸、竹村正男、太田浩敏、大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島満
- Organizer
  第49回日本臨床検査医学会東海・北陸支部総会第320回日本臨床化学会東海・北陸支部例会連合大会
- Place of Presentation
  名古屋
- Year and Date
  2010-03-14
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2010
- Author(s)
  Tsukada Y, Osawa Y, ら
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010
- Place of Presentation
  中国北京
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance.2010
- Author(s)
  Osawa Y, ら
- Organizer
  Digestive Disease Week (DDW) 2010
- Place of Presentation
  米国ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] An analysis of CD133 positive bone marrow in oval cell induced model and a role of CD133 bone marrow in mice with liver fibrosis.2010
- Author(s)
  Suetsugu A, Nagaki M, Osawa Y, Hoffman RM, Moriwaki H
- Organizer
  Digestive Disease Week (DDW) 2010.
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Free Paper Session 「Basic aspects of inflammation and fibrosis in the liver and pancreas」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Kimura K, Moriwaki H.
- Organizer
  The 18th United European Gastroenterology Week (UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] An analysis of CD133 positive bone marrow in oval cell induced model and a role of CD133 bone marrow in mice with liver fibrosis.2010
- Author(s)
  Suetsugu A, Osawa Y, ら
- Organizer
  Digestive Disease Week (DDW) 2010
- Place of Presentation
  米国ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2010
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010.
- Place of Presentation
  Beijing.China
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Use of RFP and GFP transgenic nude mice to study the tumor microenvironment of metastasis.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Momiyana M, Bouvet M, Hoffman RM
- Organizer
  American association of cancer research 101^<st> annual meeting 2010.
- Place of Presentation
  Washington DC USA
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Inhibition of acid sphingomyelinasecauses hepatic glucose intolerance and insulin resistance2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
- Organizer
  DDW 2010 New Orleans
- Place of Presentation
  USA
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-21390179
[Presentation] Role of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, ら
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2010
- Place of Presentation
  中国北京
- Year and Date
  2010-03-25
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割2009
- Author(s)
  大澤陽介, ら
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 前駆細胞移植における細胞生存および分化に対する細胞外マトリックスの重要性2009
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、森脇久隆
- Organizer
  DDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] TLR4-MyD88-NFκBシグナルによる肝星細胞活性化と肝線維症における役割2009
- Author(s)
  石亦宏、大澤陽介, ら
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] ワークショップ3「免疫担当細胞異常からみた肝疾患の動態」胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割.2009
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] パネルディスカッション「自然免疫と消化器疾患」TLR4-MyD88-NFκBシグナルによる肝星細胞活性化と肝線維症における役割2009
- Author(s)
  石亦宏, 大澤陽介, 藤本治朗
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver.2009
- Author(s)
  Osawa Y, Nagaki M, Ito H, Seishima M, Moriwaki H
- Organizer
  Digestive Disease Week (DDW) 2009.
- Place of Presentation
  Chicago USA
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおける肝細胞抗アポトーシス獲得機序の検討2009
- Author(s)
  大澤陽介, ら
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] ワークショップ3「免疫担当細胞異常からみた肝疾患の動態」胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割2009
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ワークショップ「免疫担当細胞異常からみた肝疾患の動態」胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割2009
- Author(s)
  大澤陽介, 永木正仁, 森脇久隆
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 肝前駆細胞移植における細胞生存および分化に対する細胞外マトリックスの重要性2009
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver2009
- Author(s)
  Osawa Y, ら
- Organizer
  Digestive Disease Week (DDW) 2009
- Place of Presentation
  米国シカゴ
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-21790657
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおける肝細胞抗アポトーシス獲得機序の検討2009
- Author(s)
  大澤陽介、永木正仁、伊藤弘康、清島満、森脇久隆
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver2008
- Author(s)
  Osawa Y
- Organizer
  Digestive Disease Week (DDW) 2008
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] ラット2-AAF投与後部分肝切除モデル(modified Solt-Farber model)におけるHNF-4遺伝子導入における肝細胞分化誘導の検討2008
- Author(s)
  小木曽富生、永木正仁、塚田良彦、末次淳、大澤陽介、森脇久隆
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver2008
- Author(s)
  Osawa Y
- Organizer
  Digestive Disease Week (DDW) 2008
- Place of Presentation
  サンディエゴ
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] 肝星細胞におけるコラーゲン産生にかかわるfocalおよびsystemic factorの検計2007
- Author(s)
  大澤陽介
- Organizer
  第11回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] 肝星細胞におけるコラーゲン産生にかかわるfocal およびsystemic factor の検討2007
- Author(s)
  大澤陽介
- Organizer
  第11 回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] Systemic Mediators Induce Fibrogenic Effects in Normal Liver after Partial Bile Duct Ligation2007
- Author(s)
  Osawa Y
- Organizer
  Digestive Disease Week (DDW) 2007
- Place of Presentation
  ワシントンDC
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] 胆管結紮により誘導された慢性肝障害マウスモデルにおける抗アポトーシス獲得機序2007
- Author(s)
  大澤陽介
- Organizer
  第18回The Meeting of Liver andImmunology
- Place of Presentation
  京都
- Year and Date
  2007-09-01
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] 胆管結紮により誘導された慢性肝障害マウスモデルにおける抗アポトーシス獲得機序2007
- Author(s)
  大澤陽介
- Organizer
  第18 回The Meeting of Liver and Immunology
- Place of Presentation
  京都
- Year and Date
  2007-09-01
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] Systemic Mediators Induce Fibrogenic Effects in Normal Liver after Partial Bile Duct Ligation2007
- Author(s)
  Osawa Y
- Organizer
  Digestive Disease Week(DDW)2007
- Place of Presentation
  ワシントンDC
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19790478
[Presentation] 非アルコール性肝脂肪化におけるトリプトファンの影響
- Author(s)
  大澤陽介
- Organizer
  JDDW2012 (第16回日本肝臓学会大会)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] L-Tryptophan-mediated enhancement of susceptibility to NAFLD in dependent on the mTOR
- Author(s)
  Osawa Y
- Organizer
  Asian Pacific Digestive Week (APDW2012)
- Place of Presentation
  バンコク(タイ）
- Data Source
  KAKENHI-PROJECT-23790787
[Presentation] 非アルコール性肝脂肪化におけるトリプトファンの影響
- Author(s)
  大澤陽介
- Organizer
  第48回　日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790787

1. NAKAMURA Mitsuhiro (30433204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. NAGAKI Masahito (30293559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
3. SEISHIMA Mitsuru (10171315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. ITO Hiroyasu (80373075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. MORI Ichiro (40444327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. KANAMORI Hiromitsu (20456502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. SAITO Kuniaki (80262765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. BANNO Yoshiko (50116852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KYOUGASHIMA Mamoru (50225091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MURATE Takashi (30239537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. KOZAWA Osamu (90225417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIWAKI Rie (90734202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Kanoh Hiroyuki (40566494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kimura Kiminori (70397339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. KOHARA Michinori (10250218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 末次淳 (30340079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
17. 清島眞理子 (00171314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 稲垣直樹 (30137062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YANAGIDA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 河合裕成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 斉藤邦明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. 山添太士

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 西原利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 由雄祥代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Osawa Yosuke 大澤 陽介

大澤 陽介 オオサワ ヨウスケ

OSAWA Yosuke 大澤 陽介

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うっ血による肝細胞がんおよび転移性肝がん増殖機構の解明Principal Investigator

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Development of new anti-fibrotic therapeutic drug for targeting Wnt signal

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Acid sphingomyelinase-derived liver macrophage inhibits growth of metastatic colon cancer in the liver.Principal Investigator

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New barrier function of stratum corneum and its regulation in inflammatory skin diseases

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Molecular targets of low-molecular-weight heat shock proteins in hepatocellular carcinoma cell proliferation

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Role of L-Tryptophan on NAFLD and NASHPrincipal Investigator

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Screening and gene analysis for the protection from muscle damage by statin drugs

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Control mechanism of anti-cancer drug resistance by sphingolipid

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Role of Kupffer cells on chronic liver injuryPrincipal Investigator

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Development of regenerative medicine and therapeutic system for hepatic failure applied by hepatocyte nuclear factor 4

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Role of sphingolipids on hepatocyte apoptosis of chronic liver injuryPrincipal Investigator

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[Book] 2nd edition of Essentials of Apoptosis. Part III Apoptosis in mammalian physiology and pathogenesis. Chapter 24 Apoptosis in liver injury and liver diseases.2009

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[Journal Article] Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells <i>in vitro</i>2023

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DOI

Osawa Yosuke 大澤陽介

大澤陽介オオサワヨウスケ

OSAWA Yosuke 大澤陽介